From ea70f9c3f1f4321baebe37cfa2d0937d4d5887c6 Mon Sep 17 00:00:00 2001 From: Maksym Date: Sun, 10 Mar 2024 10:02:54 -0400 Subject: [PATCH] LLMFactCheck --- data/true_false_chembl_labeled.csv | 9200 ++++++++++----------- data/true_false_chembl_labeled_triple.csv | 9200 ++++++++++----------- false_labeled_records.csv | 9200 ++++++++++----------- false_sentence_data.csv | 1 - false_triple_data.csv | 9200 ++++++++++----------- util/chembl/convert_false.py | 4 +- 6 files changed, 18402 insertions(+), 18403 deletions(-) diff --git a/data/true_false_chembl_labeled.csv b/data/true_false_chembl_labeled.csv index 583123a..d0a95fb 100644 --- a/data/true_false_chembl_labeled.csv +++ b/data/true_false_chembl_labeled.csv @@ -5399,4603 +5399,4603 @@ Predicate ID,Triple,Sentence ID,Sentence,Question,Label,Reference 24691450,Methylprednisolone related to plantar fasciitis,498,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,"Is the triple ""Methylprednisolone related to plantar fasciitis"" supported by the sentence: ""A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.""?",False, 24586108,Methylprednisolone related to alcoholic hepatitis,499,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,"Is the triple ""Methylprednisolone related to alcoholic hepatitis"" supported by the sentence: ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.""?",False, 24559507,Methylprednisolone related to respiratory system disorder,500,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,"Is the triple ""Methylprednisolone related to respiratory system disorder"" supported by the sentence: ""[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].""?",False, -23573980,Methylprednisolone related to pneumonia,1,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,"Is the triple ""Methylprednisolone related to pneumonia"" supported by the sentence: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?",False, -23514846,Methylprednisolone related to carpal tunnel syndrome,2,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,"Is the triple ""Methylprednisolone related to carpal tunnel syndrome"" supported by the sentence: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?",False, -23364897,Methylprednisolone related to West syndrome,3,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,"Is the triple ""Methylprednisolone related to West syndrome"" supported by the sentence: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?",False, -22495910,Methylprednisolone related to myocarditis,4,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,"Is the triple ""Methylprednisolone related to myocarditis"" supported by the sentence: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?",False, -22175056,Methylprednisolone related to myopathy,5,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.","Is the triple ""Methylprednisolone related to myopathy"" supported by the sentence: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?",False, -20879022,Methylprednisolone related to Pain,6,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.","Is the triple ""Methylprednisolone related to Pain"" supported by the sentence: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?",False, -20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,"Is the triple ""Methylprednisolone related to chronic progressive multiple sclerosis"" supported by the sentence: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?",False, -20290784,Methylprednisolone related to membranous glomerulonephritis,8,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,"Is the triple ""Methylprednisolone related to membranous glomerulonephritis"" supported by the sentence: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?",False, -20286711,Methylprednisolone related to neuromyelitis optica,9,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".","Is the triple ""Methylprednisolone related to neuromyelitis optica"" supported by the sentence: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?",False, -19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,"Is the triple ""Methylprednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?",False, -18938435,Methylprednisolone related to graft versus host disease,11,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,"Is the triple ""Methylprednisolone related to graft versus host disease"" supported by the sentence: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?",False, -17333962,Methylprednisolone related to Inflammation,12,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,"Is the triple ""Methylprednisolone related to Inflammation"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?",False, -17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,"Is the triple ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?",False, -15936572,Methylprednisolone related to endocrine exophthalmos,14,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,"Is the triple ""Methylprednisolone related to endocrine exophthalmos"" supported by the sentence: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?",False, -15072844,Methylprednisolone related to Edema,15,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.","Is the triple ""Methylprednisolone related to Edema"" supported by the sentence: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?",False, -14876749,Methylprednisolone related to osteoarthritis,16,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,"Is the triple ""Methylprednisolone related to osteoarthritis"" supported by the sentence: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?",False, -14399082,Methylprednisolone related to aplastic anemia,17,Long-term results of high-dose methylprednisolone in aplastic anemia.,"Is the triple ""Methylprednisolone related to aplastic anemia"" supported by the sentence: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?",False, -14398237,Methylprednisolone related to IgA glomerulonephritis,18,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.","Is the triple ""Methylprednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?",False, -14278238,"Methylprednisolone related to dermatitis, atopic",19,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.","Is the triple ""Methylprednisolone related to dermatitis, atopic"" supported by the sentence: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?",False, -14166179,Methylprednisolone related to cardiac arrest,20,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.","Is the triple ""Methylprednisolone related to cardiac arrest"" supported by the sentence: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?",False, -12755316,Methylprednisolone related to plasma cell myeloma,21,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,"Is the triple ""Methylprednisolone related to plasma cell myeloma"" supported by the sentence: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?",False, -12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,"Is the triple ""Methylprednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?",False, -11720471,Methylprednisolone related to systemic lupus erythematosus,23,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,"Is the triple ""Methylprednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?",False, -10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,"Is the triple ""Methylprednisolone related to immunoglobulin a vasculitis"" supported by the sentence: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?",False, -10763477,Methylprednisolone related to ulcerative colitis,25,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,"Is the triple ""Methylprednisolone related to ulcerative colitis"" supported by the sentence: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?",False, -10558884,Methylprednisolone related to lupus nephritis,26,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,"Is the triple ""Methylprednisolone related to lupus nephritis"" supported by the sentence: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?",False, -10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.","Is the triple ""Methylprednisolone related to adult acute respiratory distress syndrome"" supported by the sentence: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?",False, -9229208,Methylprednisolone related to vestibular neuronitis,28,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.","Is the triple ""Methylprednisolone related to vestibular neuronitis"" supported by the sentence: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?",False, -9003326,Methylprednisolone related to systemic sclerosis,29,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,"Is the triple ""Methylprednisolone related to systemic sclerosis"" supported by the sentence: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?",False, -8447481,Methylprednisolone related to rheumatoid arthritis,30,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,"Is the triple ""Methylprednisolone related to rheumatoid arthritis"" supported by the sentence: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?",False, -8282330,Methylprednisolone related to spinal cord injury,31,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.","Is the triple ""Methylprednisolone related to spinal cord injury"" supported by the sentence: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?",False, -7944646,Methylprednisolone related to myasthenia gravis,32,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,"Is the triple ""Methylprednisolone related to myasthenia gravis"" supported by the sentence: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?",False, -7668599,Methylprednisolone related to multiple sclerosis,33,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,"Is the triple ""Methylprednisolone related to multiple sclerosis"" supported by the sentence: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?",False, -7443745,Methylprednisolone related to asthma,34,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.","Is the triple ""Methylprednisolone related to asthma"" supported by the sentence: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?",False, -24973247,Methylprednisolone causes lupus nephritis,35,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.","Is the triple ""Methylprednisolone causes lupus nephritis"" supported by the sentence: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?",False, -24161886,Methylprednisolone causes Edema,36,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,"Is the triple ""Methylprednisolone causes Edema"" supported by the sentence: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?",False, -18534953,Methylprednisolone causes Inflammation,37,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.","Is the triple ""Methylprednisolone causes Inflammation"" supported by the sentence: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?",False, -18260665,Methylprednisolone causes neoplasm,38,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,"Is the triple ""Methylprednisolone causes neoplasm"" supported by the sentence: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?",False, -17307095,Methylprednisolone causes pneumonia,39,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.","Is the triple ""Methylprednisolone causes pneumonia"" supported by the sentence: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?",False, -15906641,Methylprednisolone causes Pain,40,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,"Is the triple ""Methylprednisolone causes Pain"" supported by the sentence: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?",False, -13166073,Methylprednisolone causes thrombocytopenia,41,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.","Is the triple ""Methylprednisolone causes thrombocytopenia"" supported by the sentence: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?",False, -12672767,Methylprednisolone causes drug-induced liver injury,42,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.","Is the triple ""Methylprednisolone causes drug-induced liver injury"" supported by the sentence: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?",False, -8525599,Methylprednisolone causes myopathy,43,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.","Is the triple ""Methylprednisolone causes myopathy"" supported by the sentence: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?",False, -27357949,Methylprednisolone affects neoplasm,44,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.","Is the triple ""Methylprednisolone affects neoplasm"" supported by the sentence: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?",False, -24420470,Methylprednisolone affects Inflammation,45,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.","Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?",False, -23472756,Methylprednisolone affects Inflammation,46,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,"Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?",False, -20530617,Methylprednisolone affects systemic sclerosis,47,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.","Is the triple ""Methylprednisolone affects systemic sclerosis"" supported by the sentence: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?",False, -20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.","Is the triple ""Methylprednisolone affects adult acute respiratory distress syndrome"" supported by the sentence: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?",False, -17649050,Methylprednisolone affects optic nerve disorder,49,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,"Is the triple ""Methylprednisolone affects optic nerve disorder"" supported by the sentence: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?",False, -16634377,Methylprednisolone affects myasthenia gravis,50,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,"Is the triple ""Methylprednisolone affects myasthenia gravis"" supported by the sentence: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?",False, -16277488,Methylprednisolone affects neuromyelitis optica,51,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,"Is the triple ""Methylprednisolone affects neuromyelitis optica"" supported by the sentence: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?",False, -15906642,Methylprednisolone affects Pain,52,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?",False, -15610554,Methylprednisolone affects rheumatoid arthritis,53,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,"Is the triple ""Methylprednisolone affects rheumatoid arthritis"" supported by the sentence: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?",False, -15186368,Methylprednisolone affects graft versus host disease,54,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,"Is the triple ""Methylprednisolone affects graft versus host disease"" supported by the sentence: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?",False, -14891106,Methylprednisolone affects kidney disorder,55,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.","Is the triple ""Methylprednisolone affects kidney disorder"" supported by the sentence: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?",False, -11819955,Methylprednisolone affects spinal cord injury,56,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.","Is the triple ""Methylprednisolone affects spinal cord injury"" supported by the sentence: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?",False, -10845505,Methylprednisolone affects Pain,57,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?",False, -10048898,Methylprednisolone affects ulcerative colitis,58,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,"Is the triple ""Methylprednisolone affects ulcerative colitis"" supported by the sentence: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?",False, -9646753,Methylprednisolone affects multiple sclerosis,59,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,"Is the triple ""Methylprednisolone affects multiple sclerosis"" supported by the sentence: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?",False, -9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).","Is the triple ""Methylprednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?",False, -9107378,Methylprednisolone affects Edema,61,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.","Is the triple ""Methylprednisolone affects Edema"" supported by the sentence: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?",False, -8596544,Methylprednisolone affects asthma,62,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,"Is the triple ""Methylprednisolone affects asthma"" supported by the sentence: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?",False, -8330909,Methylprednisolone affects systemic lupus erythematosus,63,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,"Is the triple ""Methylprednisolone affects systemic lupus erythematosus"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?",False, -19744632,Methylprednisolone disrupts Edema,64,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.","Is the triple ""Methylprednisolone disrupts Edema"" supported by the sentence: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?",False, -18407557,Methylprednisolone disrupts thrombocytopenia,65,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,"Is the triple ""Methylprednisolone disrupts thrombocytopenia"" supported by the sentence: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?",False, -11106658,Methylprednisolone disrupts Pain,66,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.","Is the triple ""Methylprednisolone disrupts Pain"" supported by the sentence: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?",False, -8640603,Methylprednisolone disrupts Inflammation,67,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,"Is the triple ""Methylprednisolone disrupts Inflammation"" supported by the sentence: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?",False, -23934495,Methylprednisolone prevents Cognitive impairment,68,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.","Is the triple ""Methylprednisolone prevents Cognitive impairment"" supported by the sentence: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?",False, -20014108,Methylprednisolone prevents rheumatoid arthritis,69,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).","Is the triple ""Methylprednisolone prevents rheumatoid arthritis"" supported by the sentence: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?",False, -18266414,Methylprednisolone prevents Abdominal pain,70,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,"Is the triple ""Methylprednisolone prevents Abdominal pain"" supported by the sentence: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?",False, -14967074,Methylprednisolone prevents asthma,71,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,"Is the triple ""Methylprednisolone prevents asthma"" supported by the sentence: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?",False, -9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,"Is the triple ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?",False, -8345063,Methylprednisolone prevents Pain,73,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.","Is the triple ""Methylprednisolone prevents Pain"" supported by the sentence: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?",False, -8291272,Methylprednisolone prevents graft versus host disease,74,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,"Is the triple ""Methylprednisolone prevents graft versus host disease"" supported by the sentence: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?",False, -7980138,Methylprednisolone prevents spinal cord injury,75,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.","Is the triple ""Methylprednisolone prevents spinal cord injury"" supported by the sentence: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?",False, -7414405,Methylprednisolone prevents Edema,76,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.","Is the triple ""Methylprednisolone prevents Edema"" supported by the sentence: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?",False, -18106042,Methylprednisolone predisposes pneumonia,77,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,"Is the triple ""Methylprednisolone predisposes pneumonia"" supported by the sentence: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?",False, -9645180,Methylprednisolone predisposes Inflammation,78,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.","Is the triple ""Methylprednisolone predisposes Inflammation"" supported by the sentence: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?",False, -12905337,Cefotaxime related to Sepsis,79,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.","Is the triple ""Cefotaxime related to Sepsis"" supported by the sentence: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?",False, -24475300,Cefotaxime affects bacterial infectious disease,80,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.","Is the triple ""Cefotaxime affects bacterial infectious disease"" supported by the sentence: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?",False, -23922029,Cefotaxime affects Sepsis,81,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).","Is the triple ""Cefotaxime affects Sepsis"" supported by the sentence: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?",False, -18672205,Cefotaxime affects peritonitis,82,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.","Is the triple ""Cefotaxime affects peritonitis"" supported by the sentence: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?",False, -15853591,Cefotaxime prevents Sepsis,83,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.","Is the triple ""Cefotaxime prevents Sepsis"" supported by the sentence: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?",False, -19081412,Ceftriaxone prevents bacterial infectious disease,84,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.","Is the triple ""Ceftriaxone prevents bacterial infectious disease"" supported by the sentence: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?",False, -25827448,Gefarnate related to gastric ulcer,85,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,"Is the triple ""Gefarnate related to gastric ulcer"" supported by the sentence: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?",False, -24296137,Gefarnate related to duodenal ulcer,86,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,"Is the triple ""Gefarnate related to duodenal ulcer"" supported by the sentence: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?",False, -25993651,Gefarnate disrupts gastric ulcer,87,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,"Is the triple ""Gefarnate disrupts gastric ulcer"" supported by the sentence: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?",False, -17758516,Neobiotic related to Inflammation,88,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,"Is the triple ""Neobiotic related to Inflammation"" supported by the sentence: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?",False, -10690423,Neobiotic related to burn,89,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,"Is the triple ""Neobiotic related to burn"" supported by the sentence: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?",False, -20263460,Neobiotic affects neoplasm,90,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.","Is the triple ""Neobiotic affects neoplasm"" supported by the sentence: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?",False, -19744068,Neobiotic affects Inflammation,91,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,"Is the triple ""Neobiotic affects Inflammation"" supported by the sentence: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?",False, -24669492,Neobiotic disrupts bacterial infectious disease,92,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.","Is the triple ""Neobiotic disrupts bacterial infectious disease"" supported by the sentence: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?",False, -17119153,Neobiotic disrupts neoplasm,93,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,"Is the triple ""Neobiotic disrupts neoplasm"" supported by the sentence: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?",False, -26428369,Neobiotic prevents bacterial infectious disease,94,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Neobiotic prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, -25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,"Is the triple ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" supported by the sentence: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?",False, -22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.","Is the triple ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?",False, -21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,"Is the triple ""BLINATUMOMAB related to acute lymphoblastic leukemia"" supported by the sentence: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?",False, -27155094,Ciprofloxacin related to endophthalmitis,98,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,"Is the triple ""Ciprofloxacin related to endophthalmitis"" supported by the sentence: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?",False, -16836665,Ciprofloxacin related to Crohn disease,99,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,"Is the triple ""Ciprofloxacin related to Crohn disease"" supported by the sentence: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?",False, -19572117,Ciprofloxacin related to DNA Gyrase,100,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, -19572117,Ciprofloxacin related to DNA Gyrase,101,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, -12385742,Ciprofloxacin coexists with DNA Gyrase,102,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, -12385742,Ciprofloxacin coexists with DNA Gyrase,103,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, -17007621,Ciprofloxacin coexists with DNA Gyrase,104,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, -17007621,Ciprofloxacin coexists with DNA Gyrase,105,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, -9387116,Ciprofloxacin physically interacts with DNA Gyrase,106,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.","Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.""?",False, -8212496,Ciprofloxacin physically interacts with DNA Gyrase,107,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,"Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.""?",False, -25648466,Ciprofloxacin causes abscess,108,Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.,"Is the triple ""Ciprofloxacin causes abscess"" supported by the sentence: ""Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.""?",False, -24716241,Ciprofloxacin causes peritonitis,109,The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.,"Is the triple ""Ciprofloxacin causes peritonitis"" supported by the sentence: ""The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.""?",False, -17154464,Ciprofloxacin causes prostatitis,110,"After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).","Is the triple ""Ciprofloxacin causes prostatitis"" supported by the sentence: ""After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).""?",False, -14369807,Ciprofloxacin causes neutropenia,111,[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].,"Is the triple ""Ciprofloxacin causes neutropenia"" supported by the sentence: ""[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].""?",False, -13950319,Ciprofloxacin causes pneumonia,112,"According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.","Is the triple ""Ciprofloxacin causes pneumonia"" supported by the sentence: ""According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.""?",False, -10209213,Ciprofloxacin causes infectious disease,113,"Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.","Is the triple ""Ciprofloxacin causes infectious disease"" supported by the sentence: ""Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.""?",False, -7113733,Ciprofloxacin causes osteomyelitis,114,A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.,"Is the triple ""Ciprofloxacin causes osteomyelitis"" supported by the sentence: ""A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.""?",False, -21996198,Ciprofloxacin affects infectious disease,115,Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.,"Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.""?",False, -16563368,Ciprofloxacin affects Fever,116,"Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.""?",False, -16125923,Ciprofloxacin affects osteomyelitis,117,"Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.","Is the triple ""Ciprofloxacin affects osteomyelitis"" supported by the sentence: ""Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.""?",False, -12942741,Ciprofloxacin affects Crohn disease,118,BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.,"Is the triple ""Ciprofloxacin affects Crohn disease"" supported by the sentence: ""BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.""?",False, -11440816,Ciprofloxacin affects typhoid fever,119,A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.,"Is the triple ""Ciprofloxacin affects typhoid fever"" supported by the sentence: ""A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.""?",False, -11267024,Ciprofloxacin affects eye infectious disorder,120,The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).,"Is the triple ""Ciprofloxacin affects eye infectious disorder"" supported by the sentence: ""The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).""?",False, -10672042,Ciprofloxacin affects Abdominal Infection,121,The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.,"Is the triple ""Ciprofloxacin affects Abdominal Infection"" supported by the sentence: ""The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.""?",False, -9891814,Ciprofloxacin affects pneumonia,122,"This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.","Is the triple ""Ciprofloxacin affects pneumonia"" supported by the sentence: ""This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.""?",False, -9122989,Ciprofloxacin affects infectious disease,123,"The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.","Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.""?",False, -8956826,Ciprofloxacin affects Pseudomonas infection,124,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects Pseudomonas infection"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, -8956825,Ciprofloxacin affects cystic fibrosis,125,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects cystic fibrosis"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, -8669720,Ciprofloxacin affects Fever,126,"(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.""?",False, -7886704,Ciprofloxacin affects bronchiectasis,127,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects bronchiectasis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, -7886701,Ciprofloxacin affects chronic bronchitis,128,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects chronic bronchitis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, -7781719,Ciprofloxacin affects DNA Gyrase,129,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.","Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.""?",False, -7592205,Ciprofloxacin affects chronic obstructive pulmonary disease,130,"Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.","Is the triple ""Ciprofloxacin affects chronic obstructive pulmonary disease"" supported by the sentence: ""Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.""?",False, -18400322,Ciprofloxacin affects DNA Gyrase,131,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,"Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.""?",False, -26984478,Ciprofloxacin disrupts Fever,132,"In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.","Is the triple ""Ciprofloxacin disrupts Fever"" supported by the sentence: ""In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.""?",False, -26466958,Ciprofloxacin disrupts pneumonia,133,"At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.","Is the triple ""Ciprofloxacin disrupts pneumonia"" supported by the sentence: ""At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.""?",False, -18480207,Ciprofloxacin disrupts infectious disease,134,"We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.","Is the triple ""Ciprofloxacin disrupts infectious disease"" supported by the sentence: ""We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.""?",False, -10323767,Ciprofloxacin disrupts bacterial infectious disease with sepsis,135,Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.,"Is the triple ""Ciprofloxacin disrupts bacterial infectious disease with sepsis"" supported by the sentence: ""Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.""?",False, -27242944,Ciprofloxacin prevents pyelonephritis,136,"In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.","Is the triple ""Ciprofloxacin prevents pyelonephritis"" supported by the sentence: ""In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.""?",False, -21807033,Ciprofloxacin prevents Infection,137,25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.,"Is the triple ""Ciprofloxacin prevents Infection"" supported by the sentence: ""25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.""?",False, -16138544,Ciprofloxacin prevents diarrheal disease,138,"Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.","Is the triple ""Ciprofloxacin prevents diarrheal disease"" supported by the sentence: ""Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.""?",False, -15438014,Ciprofloxacin prevents Sepsis,139,"CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.","Is the triple ""Ciprofloxacin prevents Sepsis"" supported by the sentence: ""CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.""?",False, -14202377,Ciprofloxacin prevents plague,140,"Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.","Is the triple ""Ciprofloxacin prevents plague"" supported by the sentence: ""Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.""?",False, -12292532,Ciprofloxacin prevents endophthalmitis,141,These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.,"Is the triple ""Ciprofloxacin prevents endophthalmitis"" supported by the sentence: ""These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.""?",False, -10767980,Ciprofloxacin prevents bacterial infectious disease with sepsis,142,"To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.","Is the triple ""Ciprofloxacin prevents bacterial infectious disease with sepsis"" supported by the sentence: ""To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.""?",False, -9947057,Ciprofloxacin prevents bacterial infectious disease,143,[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].,"Is the triple ""Ciprofloxacin prevents bacterial infectious disease"" supported by the sentence: ""[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].""?",False, -8364719,Ciprofloxacin prevents pneumonia,144,The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.,"Is the triple ""Ciprofloxacin prevents pneumonia"" supported by the sentence: ""The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.""?",False, -8054296,Ciprofloxacin prevents infectious disease,145,"PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.","Is the triple ""Ciprofloxacin prevents infectious disease"" supported by the sentence: ""PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.""?",False, -18366035,Ciprofloxacin predisposes infectious disease,146,"Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.","Is the triple ""Ciprofloxacin predisposes infectious disease"" supported by the sentence: ""Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.""?",False, -15459841,Ciprofloxacin predisposes bacterial infectious disease with sepsis,147,"CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.","Is the triple ""Ciprofloxacin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.""?",False, -8758764,Ciprofloxacin predisposes gonorrhea,148,These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.,"Is the triple ""Ciprofloxacin predisposes gonorrhea"" supported by the sentence: ""These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.""?",False, -15493028,Chloramphenicol disrupts acne,149,Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.,"Is the triple ""Chloramphenicol disrupts acne"" supported by the sentence: ""Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.""?",False, -21241586,Chloramphenicol prevents eye infectious disorder,150,"Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.","Is the triple ""Chloramphenicol prevents eye infectious disorder"" supported by the sentence: ""Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.""?",False, -16722213,Rebamipide causes osteoarthritis,151,Oral administration of rebamipide was initiated on the day of OA induction.,"Is the triple ""Rebamipide causes osteoarthritis"" supported by the sentence: ""Oral administration of rebamipide was initiated on the day of OA induction.""?",False, -27679650,Rebamipide affects peptic ulcer disease,152,Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.,"Is the triple ""Rebamipide affects peptic ulcer disease"" supported by the sentence: ""Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.""?",False, -10125846,Rebamipide affects gastric ulcer,153,Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.,"Is the triple ""Rebamipide affects gastric ulcer"" supported by the sentence: ""Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.""?",False, -16923576,Rebamipide disrupts gastritis,154,"Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.","Is the triple ""Rebamipide disrupts gastritis"" supported by the sentence: ""Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.""?",False, -20953135,Rebamipide prevents peptic ulcer disease,155,CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).,"Is the triple ""Rebamipide prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).""?",False, -13727344,Rebamipide prevents gastritis,156,Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.,"Is the triple ""Rebamipide prevents gastritis"" supported by the sentence: ""Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.""?",False, -10452606,Rebamipide prevents gastric ulcer,157,These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.,"Is the triple ""Rebamipide prevents gastric ulcer"" supported by the sentence: ""These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.""?",False, -23020953,DINUTUXIMAB related to neoplasm,158,"In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.","Is the triple ""DINUTUXIMAB related to neoplasm"" supported by the sentence: ""In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.""?",False, -12385638,DINUTUXIMAB related to neuroblastoma,159,The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.,"Is the triple ""DINUTUXIMAB related to neuroblastoma"" supported by the sentence: ""The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.""?",False, -21974466,DINUTUXIMAB causes neuroblastoma,160,Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.,"Is the triple ""DINUTUXIMAB causes neuroblastoma"" supported by the sentence: ""Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.""?",False, -23929422,BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma,161,INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).,"Is the triple ""BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma"" supported by the sentence: ""INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).""?",False, -23730531,BRENTUXIMAB VEDOTIN related to mycosis fungoides,162,"These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to mycosis fungoides"" supported by the sentence: ""These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.""?",False, -23653011,BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma,163,Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.,"Is the triple ""BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma"" supported by the sentence: ""Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.""?",False, -23065539,BRENTUXIMAB VEDOTIN related to lymphoma,164,"Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to lymphoma"" supported by the sentence: ""Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.""?",False, -21812241,BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma,165,Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.,"Is the triple ""BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma"" supported by the sentence: ""Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.""?",False, -21657994,BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma,166,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, -21657993,BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma,167,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, -22071488,BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma,168,Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.,"Is the triple ""BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.""?",False, -21553377,BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma,169,"Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.","Is the triple ""BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma"" supported by the sentence: ""Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.""?",False, -23435913,BRENTUXIMAB VEDOTIN affects lymphoma,170,"Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.","Is the triple ""BRENTUXIMAB VEDOTIN affects lymphoma"" supported by the sentence: ""Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.""?",False, -20170701,Tetracycline causes periodontitis,171,"In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.","Is the triple ""Tetracycline causes periodontitis"" supported by the sentence: ""In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.""?",False, -19472933,Tetracycline causes Helicobacter pylori infectious disease,172,"In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.","Is the triple ""Tetracycline causes Helicobacter pylori infectious disease"" supported by the sentence: ""In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.""?",False, -18080767,Tetracycline affects periodontitis,173,Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.,"Is the triple ""Tetracycline affects periodontitis"" supported by the sentence: ""Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.""?",False, -17969405,Tetracycline affects bacterial infectious disease,174,"We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.","Is the triple ""Tetracycline affects bacterial infectious disease"" supported by the sentence: ""We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.""?",False, -24565223,Tetracycline prevents bacterial infectious disease,175,"Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .","Is the triple ""Tetracycline prevents bacterial infectious disease"" supported by the sentence: ""Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .""?",False, -10847016,Tetracycline prevents inclusion conjunctivitis,176,"Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.","Is the triple ""Tetracycline prevents inclusion conjunctivitis"" supported by the sentence: ""Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.""?",False, -12376615,(Alginate)n related to gastroesophageal reflux disease,177,Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.,"Is the triple ""(Alginate)n related to gastroesophageal reflux disease"" supported by the sentence: ""Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.""?",False, -11754791,(Alginate)n related to cystic fibrosis,178,Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.,"Is the triple ""(Alginate)n related to cystic fibrosis"" supported by the sentence: ""Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.""?",False, -10599430,(Alginate)n related to obesity disorder,179,[Alginate--skimmed milk mixture as an aid in obesity].,"Is the triple ""(Alginate)n related to obesity disorder"" supported by the sentence: ""[Alginate--skimmed milk mixture as an aid in obesity].""?",False, -27435796,(Alginate)n affects cystic fibrosis,180,"Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.","Is the triple ""(Alginate)n affects cystic fibrosis"" supported by the sentence: ""Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.""?",False, -27132270,(Alginate)n affects gastroesophageal reflux disease,181,Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.""?",False, -23415127,(Alginate)n affects obesity disorder,182,"Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.","Is the triple ""(Alginate)n affects obesity disorder"" supported by the sentence: ""Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.""?",False, -19854419,(Alginate)n affects gastroesophageal reflux disease,183,Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.""?",False, -8246131,(Alginate)n disrupts gastroesophageal reflux disease,184,"Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.","Is the triple ""(Alginate)n disrupts gastroesophageal reflux disease"" supported by the sentence: ""Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.""?",False, -11492096,(Alginate)n prevents gastroesophageal reflux disease,185,Alginic acid decreases postprandial upright gastroesophageal reflux.,"Is the triple ""(Alginate)n prevents gastroesophageal reflux disease"" supported by the sentence: ""Alginic acid decreases postprandial upright gastroesophageal reflux.""?",False, -23508922,(Alginate)n predisposes obesity disorder,186,The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.,"Is the triple ""(Alginate)n predisposes obesity disorder"" supported by the sentence: ""The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.""?",False, -11597598,Zolimidine related to peptic ulcer disease,187,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Zolimidine related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, -20742970,Chlorhexidine causes infectious disease,188,"Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.","Is the triple ""Chlorhexidine causes infectious disease"" supported by the sentence: ""Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.""?",False, -16147932,Chlorhexidine causes gingivitis,189,CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.,"Is the triple ""Chlorhexidine causes gingivitis"" supported by the sentence: ""CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.""?",False, -15413413,Chlorhexidine causes stomatitis,190,Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.,"Is the triple ""Chlorhexidine causes stomatitis"" supported by the sentence: ""Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.""?",False, -13735208,Chlorhexidine causes bacterial infectious disease with sepsis,191,Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.,"Is the triple ""Chlorhexidine causes bacterial infectious disease with sepsis"" supported by the sentence: ""Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.""?",False, -23793676,Chlorhexidine affects Infection,192,This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.,"Is the triple ""Chlorhexidine affects Infection"" supported by the sentence: ""This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.""?",False, -21319017,Chlorhexidine affects pneumonia,193,Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.,"Is the triple ""Chlorhexidine affects pneumonia"" supported by the sentence: ""Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.""?",False, -20585434,Chlorhexidine affects stomatitis,194,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Chlorhexidine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, -13503760,Chlorhexidine affects periodontal disorder,195,"Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.","Is the triple ""Chlorhexidine affects periodontal disorder"" supported by the sentence: ""Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.""?",False, -8506996,Chlorhexidine affects gingivitis,196,Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.,"Is the triple ""Chlorhexidine affects gingivitis"" supported by the sentence: ""Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.""?",False, -25489531,"Chlorhexidine disrupts Pneumonia, Ventilator-Associated",197,"Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).","Is the triple ""Chlorhexidine disrupts Pneumonia, Ventilator-Associated"" supported by the sentence: ""Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).""?",False, -22304373,Chlorhexidine disrupts dental caries,198,This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.,"Is the triple ""Chlorhexidine disrupts dental caries"" supported by the sentence: ""This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.""?",False, -21939464,Chlorhexidine disrupts Infection,199,"In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).","Is the triple ""Chlorhexidine disrupts Infection"" supported by the sentence: ""In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).""?",False, -19793680,Chlorhexidine disrupts bacterial infectious disease,200,This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.,"Is the triple ""Chlorhexidine disrupts bacterial infectious disease"" supported by the sentence: ""This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.""?",False, -18040358,Chlorhexidine disrupts infectious disease,201,Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.,"Is the triple ""Chlorhexidine disrupts infectious disease"" supported by the sentence: ""Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.""?",False, -11272633,Chlorhexidine disrupts gingivitis,202,The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.,"Is the triple ""Chlorhexidine disrupts gingivitis"" supported by the sentence: ""The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.""?",False, -26042520,Chlorhexidine prevents staphylococcal infection,203,"It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.","Is the triple ""Chlorhexidine prevents staphylococcal infection"" supported by the sentence: ""It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.""?",False, -22617089,Chlorhexidine prevents periodontitis,204,"Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.","Is the triple ""Chlorhexidine prevents periodontitis"" supported by the sentence: ""Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.""?",False, -22038778,Chlorhexidine prevents bacterial infectious disease,205,"CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.","Is the triple ""Chlorhexidine prevents bacterial infectious disease"" supported by the sentence: ""CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.""?",False, -22000060,Chlorhexidine prevents Infection,206,"Thus, CHX can be used to prevent subsequent biofilm infections.","Is the triple ""Chlorhexidine prevents Infection"" supported by the sentence: ""Thus, CHX can be used to prevent subsequent biofilm infections.""?",False, -21737487,"Chlorhexidine prevents Pneumonia, Ventilator-Associated",207,Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.,"Is the triple ""Chlorhexidine prevents Pneumonia, Ventilator-Associated"" supported by the sentence: ""Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.""?",False, -19905103,Chlorhexidine prevents periodontal disorder,208,"The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.","Is the triple ""Chlorhexidine prevents periodontal disorder"" supported by the sentence: ""The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.""?",False, -16765643,Chlorhexidine prevents Neonatal sepsis,209,AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).,"Is the triple ""Chlorhexidine prevents Neonatal sepsis"" supported by the sentence: ""AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).""?",False, -14052320,Chlorhexidine prevents pneumonia,210,Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.,"Is the triple ""Chlorhexidine prevents pneumonia"" supported by the sentence: ""Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.""?",False, -11830955,Chlorhexidine prevents bacterial infectious disease with sepsis,211,"Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.","Is the triple ""Chlorhexidine prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.""?",False, -11145796,Chlorhexidine prevents infectious disease,212,CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.,"Is the triple ""Chlorhexidine prevents infectious disease"" supported by the sentence: ""CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.""?",False, -10739867,Chlorhexidine prevents stomatitis,213,"The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.","Is the triple ""Chlorhexidine prevents stomatitis"" supported by the sentence: ""The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.""?",False, -10141569,Chlorhexidine prevents dental caries,214,The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.,"Is the triple ""Chlorhexidine prevents dental caries"" supported by the sentence: ""The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.""?",False, -7990742,Chlorhexidine prevents gingivitis,215,"Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.","Is the triple ""Chlorhexidine prevents gingivitis"" supported by the sentence: ""Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.""?",False, -23454202,"Chlorhexidine predisposes Pneumonia, Ventilator-Associated",216,"The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.","Is the triple ""Chlorhexidine predisposes Pneumonia, Ventilator-Associated"" supported by the sentence: ""The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.""?",False, -19942414,Chlorhexidine predisposes periodontal disorder,217,CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.,"Is the triple ""Chlorhexidine predisposes periodontal disorder"" supported by the sentence: ""CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.""?",False, -18735040,Chlorhexidine predisposes dental caries,218,"Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.","Is the triple ""Chlorhexidine predisposes dental caries"" supported by the sentence: ""Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.""?",False, -16765642,Chlorhexidine predisposes Neonatal sepsis,219,Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.,"Is the triple ""Chlorhexidine predisposes Neonatal sepsis"" supported by the sentence: ""Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.""?",False, -24905090,Nicergoline causes depressive disorder,220,"RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.","Is the triple ""Nicergoline causes depressive disorder"" supported by the sentence: ""RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.""?",False, -25103280,RAMUCIRUMAB related to hepatocellular carcinoma,221,"Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.","Is the triple ""RAMUCIRUMAB related to hepatocellular carcinoma"" supported by the sentence: ""Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.""?",False, -22612331,RAMUCIRUMAB related to neoplasm,222,"CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.","Is the triple ""RAMUCIRUMAB related to neoplasm"" supported by the sentence: ""CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.""?",False, -21600131,RAMUCIRUMAB related to non-small cell lung carcinoma,223,Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.,"Is the triple ""RAMUCIRUMAB related to non-small cell lung carcinoma"" supported by the sentence: ""Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.""?",False, -22008312,RAMUCIRUMAB affects neoplasm,224,"This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).","Is the triple ""RAMUCIRUMAB affects neoplasm"" supported by the sentence: ""This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).""?",False, -23569571,TAFASITAMAB related to diffuse large B-cell lymphoma,225,The use of tafasitamab in diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB related to diffuse large B-cell lymphoma"" supported by the sentence: ""The use of tafasitamab in diffuse large B-cell lymphoma.""?",False, -24533103,TAFASITAMAB disrupts diffuse large B-cell lymphoma,226,MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB disrupts diffuse large B-cell lymphoma"" supported by the sentence: ""MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.""?",False, -21884997,Thioctic acid related to cystinuria,227,alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.,"Is the triple ""Thioctic acid related to cystinuria"" supported by the sentence: ""alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.""?",False, -20207321,Thioctic acid related to chronic progressive multiple sclerosis,228,Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.,"Is the triple ""Thioctic acid related to chronic progressive multiple sclerosis"" supported by the sentence: ""Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.""?",False, -18115881,Thioctic acid related to hypertensive disorder,229,"INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.","Is the triple ""Thioctic acid related to hypertensive disorder"" supported by the sentence: ""INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.""?",False, -15406106,Thioctic acid related to optic neuritis,230,This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.,"Is the triple ""Thioctic acid related to optic neuritis"" supported by the sentence: ""This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.""?",False, -12204809,Thioctic acid related to type 2 diabetes mellitus,231,"As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.","Is the triple ""Thioctic acid related to type 2 diabetes mellitus"" supported by the sentence: ""As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.""?",False, -11741203,Thioctic acid related to multiple sclerosis,232,Lipoic acid in multiple sclerosis: a pilot study.,"Is the triple ""Thioctic acid related to multiple sclerosis"" supported by the sentence: ""Lipoic acid in multiple sclerosis: a pilot study.""?",False, -11010945,Thioctic acid related to AIDS,233,These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.,"Is the triple ""Thioctic acid related to AIDS"" supported by the sentence: ""These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.""?",False, -10648973,Thioctic acid related to skin disorder,234,[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].,"Is the triple ""Thioctic acid related to skin disorder"" supported by the sentence: ""[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].""?",False, -7603472,Thioctic acid related to diabetic neuropathy,235,[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].,"Is the triple ""Thioctic acid related to diabetic neuropathy"" supported by the sentence: ""[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].""?",False, -16842192,Thioctic acid causes hypertensive disorder,236,"AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.","Is the triple ""Thioctic acid causes hypertensive disorder"" supported by the sentence: ""AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.""?",False, -21111426,Thioctic acid affects optic neuritis,237,"Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.","Is the triple ""Thioctic acid affects optic neuritis"" supported by the sentence: ""Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.""?",False, -18505755,Thioctic acid affects diabetic neuropathy,238,"Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.","Is the triple ""Thioctic acid affects diabetic neuropathy"" supported by the sentence: ""Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.""?",False, -17198477,Thioctic acid affects type 2 diabetes mellitus,239,"A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.","Is the triple ""Thioctic acid affects type 2 diabetes mellitus"" supported by the sentence: ""A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.""?",False, -12393284,Thioctic acid affects Alzheimer disease,240,"The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.","Is the triple ""Thioctic acid affects Alzheimer disease"" supported by the sentence: ""The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.""?",False, -9028391,Thioctic acid affects hypertensive disorder,241,"Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.","Is the triple ""Thioctic acid affects hypertensive disorder"" supported by the sentence: ""Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.""?",False, -21111429,Thioctic acid prevents optic neuritis,242,Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.,"Is the triple ""Thioctic acid prevents optic neuritis"" supported by the sentence: ""Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.""?",False, -18775341,Thioctic acid prevents skin disorder,243,"Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.","Is the triple ""Thioctic acid prevents skin disorder"" supported by the sentence: ""Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.""?",False, -18076378,Thioctic acid prevents type 2 diabetes mellitus,244,"Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.","Is the triple ""Thioctic acid prevents type 2 diabetes mellitus"" supported by the sentence: ""Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.""?",False, -15377554,Thioctic acid prevents stroke disorder,245,We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.,"Is the triple ""Thioctic acid prevents stroke disorder"" supported by the sentence: ""We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.""?",False, -13878249,Thioctic acid prevents Alzheimer disease,246,Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.,"Is the triple ""Thioctic acid prevents Alzheimer disease"" supported by the sentence: ""Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.""?",False, -8826102,Thioctic acid prevents hypertensive disorder,247,"The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.","Is the triple ""Thioctic acid prevents hypertensive disorder"" supported by the sentence: ""The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.""?",False, -8682086,Thioctic acid prevents diabetic neuropathy,248,alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.,"Is the triple ""Thioctic acid prevents diabetic neuropathy"" supported by the sentence: ""alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.""?",False, -15385084,Thioctic acid predisposes Alzheimer disease,249,"Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.","Is the triple ""Thioctic acid predisposes Alzheimer disease"" supported by the sentence: ""Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.""?",False, -26276598,Ampicillin related to Sepsis,250,Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.,"Is the triple ""Ampicillin related to Sepsis"" supported by the sentence: ""Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.""?",False, -19644222,Ampicillin related to pneumonia,251,"This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.","Is the triple ""Ampicillin related to pneumonia"" supported by the sentence: ""This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.""?",False, -27702232,Ampicillin causes Sepsis,252,Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.,"Is the triple ""Ampicillin causes Sepsis"" supported by the sentence: ""Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.""?",False, -15854005,Ampicillin causes pneumonia,253,"Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.","Is the triple ""Ampicillin causes pneumonia"" supported by the sentence: ""Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.""?",False, -14938843,Ampicillin affects Sepsis,254,"No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.","Is the triple ""Ampicillin affects Sepsis"" supported by the sentence: ""No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.""?",False, -8930713,Ampicillin affects gonorrhea,255,A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.,"Is the triple ""Ampicillin affects gonorrhea"" supported by the sentence: ""A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.""?",False, -21012437,Ampicillin disrupts gonorrhea,256,"Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.","Is the triple ""Ampicillin disrupts gonorrhea"" supported by the sentence: ""Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.""?",False, -24823382,Ampicillin prevents Infection,257,"Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.","Is the triple ""Ampicillin prevents Infection"" supported by the sentence: ""Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.""?",False, -22838487,Ampicillin prevents chorioamnionitis,258,OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.,"Is the triple ""Ampicillin prevents chorioamnionitis"" supported by the sentence: ""OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.""?",False, -18801502,Ampicillin prevents Sepsis,259,"JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.","Is the triple ""Ampicillin prevents Sepsis"" supported by the sentence: ""JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.""?",False, -17465667,Ampicillin prevents pneumonia,260,"Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).","Is the triple ""Ampicillin prevents pneumonia"" supported by the sentence: ""Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).""?",False, -13675414,Ampicillin predisposes Sepsis,261,Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.,"Is the triple ""Ampicillin predisposes Sepsis"" supported by the sentence: ""Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.""?",False, -26048573,Carbenicillin causes bacterial infectious disease,262,"Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.","Is the triple ""Carbenicillin causes bacterial infectious disease"" supported by the sentence: ""Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.""?",False, -19319362,Benzoyl Peroxide related to acne,263,"Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.","Is the triple ""Benzoyl Peroxide related to acne"" supported by the sentence: ""Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.""?",False, -10427135,Benzoyl Peroxide affects acne,264,The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).,"Is the triple ""Benzoyl Peroxide affects acne"" supported by the sentence: ""The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).""?",False, -7769964,Benzoyl Peroxide disrupts acne,265,We used benzoyl peroxide to bring about rapid suppression of P acnes.,"Is the triple ""Benzoyl Peroxide disrupts acne"" supported by the sentence: ""We used benzoyl peroxide to bring about rapid suppression of P acnes.""?",False, -12531968,Benzoyl Peroxide prevents acne,266,"Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.","Is the triple ""Benzoyl Peroxide prevents acne"" supported by the sentence: ""Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.""?",False, -11597597,Proglumide related to peptic ulcer disease,267,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Proglumide related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, -18195146,Pirenzepine causes peptic ulcer disease,268,Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.,"Is the triple ""Pirenzepine causes peptic ulcer disease"" supported by the sentence: ""Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.""?",False, -13022427,Pirenzepine affects gastroesophageal reflux disease,269,"However, the effect of pirenzepine on GERD remains to be defined.","Is the triple ""Pirenzepine affects gastroesophageal reflux disease"" supported by the sentence: ""However, the effect of pirenzepine on GERD remains to be defined.""?",False, -18547780,Pirenzepine prevents peptic ulcer disease,270,Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.,"Is the triple ""Pirenzepine prevents peptic ulcer disease"" supported by the sentence: ""Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.""?",False, -9345084,Magnesium Oxide related to constipation disorder,271,"In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.","Is the triple ""Magnesium Oxide related to constipation disorder"" supported by the sentence: ""In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.""?",False, -19628284,Magnesium Oxide disrupts constipation disorder,272,"However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.","Is the triple ""Magnesium Oxide disrupts constipation disorder"" supported by the sentence: ""However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.""?",False, -25714783,Ticarcillin prevents Sepsis,273,A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.,"Is the triple ""Ticarcillin prevents Sepsis"" supported by the sentence: ""A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.""?",False, -24735602,Urea related to hepatocellular carcinoma,274,"Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.","Is the triple ""Urea related to hepatocellular carcinoma"" supported by the sentence: ""Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.""?",False, -18901918,Urea related to radiodermatitis,275,AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.,"Is the triple ""Urea related to radiodermatitis"" supported by the sentence: ""AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.""?",False, -16423422,Urea related to skin disorder,276,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to skin disorder"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, -16423421,Urea related to psoriasis,277,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to psoriasis"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, -10983160,"Urea related to dermatitis, atopic",278,[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].,"Is the triple ""Urea related to dermatitis, atopic"" supported by the sentence: ""[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].""?",False, -9883467,Urea related to diabetes mellitus,279,"Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.","Is the triple ""Urea related to diabetes mellitus"" supported by the sentence: ""Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.""?",False, -9435238,Urea related to type 2 diabetes mellitus,280,"Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.","Is the triple ""Urea related to type 2 diabetes mellitus"" supported by the sentence: ""Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.""?",False, -7778173,Urea related to ornithine carbamoyltransferase deficiency,281,We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).,"Is the triple ""Urea related to ornithine carbamoyltransferase deficiency"" supported by the sentence: ""We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).""?",False, -17162115,Urea causes diabetes mellitus,282,"Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.","Is the triple ""Urea causes diabetes mellitus"" supported by the sentence: ""Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.""?",False, -16469778,Urea causes type 2 diabetes mellitus,283,"To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.","Is the triple ""Urea causes type 2 diabetes mellitus"" supported by the sentence: ""To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.""?",False, -18510405,Urea affects hepatocellular carcinoma,284,[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].,"Is the triple ""Urea affects hepatocellular carcinoma"" supported by the sentence: ""[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].""?",False, -10531949,Urea affects diabetes mellitus,285,[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].,"Is the triple ""Urea affects diabetes mellitus"" supported by the sentence: ""[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].""?",False, -8735554,Urea affects type 2 diabetes mellitus,286,Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.,"Is the triple ""Urea affects type 2 diabetes mellitus"" supported by the sentence: ""Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.""?",False, -25972859,Urea produces citrullinemia,287,Citrullinemia with defective urea production.,"Is the triple ""Urea produces citrullinemia"" supported by the sentence: ""Citrullinemia with defective urea production.""?",False, -18901919,Urea prevents radiodermatitis,288,This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.,"Is the triple ""Urea prevents radiodermatitis"" supported by the sentence: ""This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.""?",False, -15303897,Urea prevents Palmar-plantar erythrodysesthesia syndrome,289,This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.,"Is the triple ""Urea prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.""?",False, -19154964,Urea predisposes type 2 diabetes mellitus,290,"A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.","Is the triple ""Urea predisposes type 2 diabetes mellitus"" supported by the sentence: ""A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.""?",False, -21175471,Mannitol related to intracranial hypertension,291,"To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.","Is the triple ""Mannitol related to intracranial hypertension"" supported by the sentence: ""To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.""?",False, -17706176,Mannitol related to acute kidney failure,292,"Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.","Is the triple ""Mannitol related to acute kidney failure"" supported by the sentence: ""Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.""?",False, -17429747,Mannitol related to stroke disorder,293,The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.,"Is the triple ""Mannitol related to stroke disorder"" supported by the sentence: ""The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.""?",False, -15130853,Mannitol related to brain cancer,294,"In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.","Is the triple ""Mannitol related to brain cancer"" supported by the sentence: ""In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.""?",False, -13201402,Mannitol related to cystic fibrosis,295,Inhaled mannitol in cystic fibrosis.,"Is the triple ""Mannitol related to cystic fibrosis"" supported by the sentence: ""Inhaled mannitol in cystic fibrosis.""?",False, -12470912,Mannitol related to brain edema,296,"The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.","Is the triple ""Mannitol related to brain edema"" supported by the sentence: ""The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.""?",False, -11875924,Mannitol related to ciguatera fish poisoning,297,"The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.","Is the triple ""Mannitol related to ciguatera fish poisoning"" supported by the sentence: ""The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.""?",False, -10780851,Mannitol related to brain injury,298,Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.,"Is the triple ""Mannitol related to brain injury"" supported by the sentence: ""Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.""?",False, -8946483,Mannitol related to bronchiectasis,299,"REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.","Is the triple ""Mannitol related to bronchiectasis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.""?",False, -7891128,Mannitol related to injury,300,"The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.","Is the triple ""Mannitol related to injury"" supported by the sentence: ""The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.""?",False, -26278567,Mannitol causes brain cancer,301,Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.,"Is the triple ""Mannitol causes brain cancer"" supported by the sentence: ""Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.""?",False, -25099324,Mannitol causes hearing loss disorder,302,A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.,"Is the triple ""Mannitol causes hearing loss disorder"" supported by the sentence: ""A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.""?",False, -21259902,Mannitol causes brain injury,303,"In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.","Is the triple ""Mannitol causes brain injury"" supported by the sentence: ""In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.""?",False, -18351985,Mannitol causes hypotensive disorder,304,"All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.","Is the triple ""Mannitol causes hypotensive disorder"" supported by the sentence: ""All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.""?",False, -15545947,Mannitol causes brain edema,305,"This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.","Is the triple ""Mannitol causes brain edema"" supported by the sentence: ""This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.""?",False, -12105301,Mannitol causes intracranial hypertension,306,"There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.","Is the triple ""Mannitol causes intracranial hypertension"" supported by the sentence: ""There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.""?",False, -11383337,Mannitol causes injury,307,DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.,"Is the triple ""Mannitol causes injury"" supported by the sentence: ""DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.""?",False, -9825580,Mannitol causes acute kidney failure,308,"In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.","Is the triple ""Mannitol causes acute kidney failure"" supported by the sentence: ""In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.""?",False, -22439282,Mannitol affects acute kidney failure,309,Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.,"Is the triple ""Mannitol affects acute kidney failure"" supported by the sentence: ""Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.""?",False, -18431992,Mannitol affects hypotensive disorder,310,It is unknown if mannitol is a contributing factor in the observed hypotension.,"Is the triple ""Mannitol affects hypotensive disorder"" supported by the sentence: ""It is unknown if mannitol is a contributing factor in the observed hypotension.""?",False, -10780860,Mannitol affects brain injury,311,"Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.","Is the triple ""Mannitol affects brain injury"" supported by the sentence: ""Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.""?",False, -10701562,Mannitol affects injury,312,THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.,"Is the triple ""Mannitol affects injury"" supported by the sentence: ""THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.""?",False, -10686125,"Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive",313,"EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.","Is the triple ""Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.""?",False, -9315186,Mannitol affects intracranial hypertension,314,"OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.","Is the triple ""Mannitol affects intracranial hypertension"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.""?",False, -7084537,Mannitol affects brain edema,315,The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.,"Is the triple ""Mannitol affects brain edema"" supported by the sentence: ""The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.""?",False, -27493988,Mannitol disrupts injury,316,"We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.","Is the triple ""Mannitol disrupts injury"" supported by the sentence: ""We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.""?",False, -26052295,Mannitol disrupts brain edema,317,Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.,"Is the triple ""Mannitol disrupts brain edema"" supported by the sentence: ""Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.""?",False, -18331127,Mannitol prevents Pain,318,"Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.","Is the triple ""Mannitol prevents Pain"" supported by the sentence: ""Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.""?",False, -17838550,Mannitol prevents brain injury,319,"Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.","Is the triple ""Mannitol prevents brain injury"" supported by the sentence: ""Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.""?",False, -9550870,Mannitol prevents acute kidney failure,320,"However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.","Is the triple ""Mannitol prevents acute kidney failure"" supported by the sentence: ""However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.""?",False, -8530867,Mannitol prevents brain edema,321,BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.,"Is the triple ""Mannitol prevents brain edema"" supported by the sentence: ""BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.""?",False, -7816754,Mannitol prevents intracranial hypertension,322,"For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.","Is the triple ""Mannitol prevents intracranial hypertension"" supported by the sentence: ""For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.""?",False, -21038220,Mannitol exacerbates intracranial hypertension,323,Does a bolus of mannitol initially aggravate intracranial hypertension?,"Is the triple ""Mannitol exacerbates intracranial hypertension"" supported by the sentence: ""Does a bolus of mannitol initially aggravate intracranial hypertension?""?",False, -23554906,Mannitol predisposes brain injury,324,"This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.","Is the triple ""Mannitol predisposes brain injury"" supported by the sentence: ""This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.""?",False, -23171283,Mannitol predisposes acute kidney failure,325,"In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).","Is the triple ""Mannitol predisposes acute kidney failure"" supported by the sentence: ""In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).""?",False, -15337034,Mannitol predisposes brain edema,326,D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.,"Is the triple ""Mannitol predisposes brain edema"" supported by the sentence: ""D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.""?",False, -9368450,Mannitol predisposes injury,327,"Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.","Is the triple ""Mannitol predisposes injury"" supported by the sentence: ""Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.""?",False, -25560945,Artesunic acid affects neoplasm,328,Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.""?",False, -20380317,Artesunic acid affects neoplasm,329,Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.""?",False, -17022154,Artesunic acid affects cytomegalovirus infection,330,"OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.","Is the triple ""Artesunic acid affects cytomegalovirus infection"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.""?",False, -15447136,Artesunic acid affects malaria,331,BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.,"Is the triple ""Artesunic acid affects malaria"" supported by the sentence: ""BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.""?",False, -14695052,Artesunic acid affects Fever,332,"In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.","Is the triple ""Artesunic acid affects Fever"" supported by the sentence: ""In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.""?",False, -9350747,Artesunic acid affects Plasmodium falciparum malaria,333,The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.,"Is the triple ""Artesunic acid affects Plasmodium falciparum malaria"" supported by the sentence: ""The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.""?",False, -19053159,Artesunic acid disrupts Plasmodium falciparum malaria,334,"BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.","Is the triple ""Artesunic acid disrupts Plasmodium falciparum malaria"" supported by the sentence: ""BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.""?",False, -17269195,Artesunic acid disrupts neoplasm,335,The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.,"Is the triple ""Artesunic acid disrupts neoplasm"" supported by the sentence: ""The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.""?",False, -16806460,Artesunic acid disrupts malaria,336,"CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.","Is the triple ""Artesunic acid disrupts malaria"" supported by the sentence: ""CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.""?",False, -10013375,Artesunic acid prevents schistosomiasis,337,CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.,"Is the triple ""Artesunic acid prevents schistosomiasis"" supported by the sentence: ""CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.""?",False, -8540473,Artesunic acid prevents malaria,338,"INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.","Is the triple ""Artesunic acid prevents malaria"" supported by the sentence: ""INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.""?",False, -16567243,Artesunic acid predisposes malaria,339,"We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.","Is the triple ""Artesunic acid predisposes malaria"" supported by the sentence: ""We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.""?",False, -27639365,Artemether affects Fever,340,RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.,"Is the triple ""Artemether affects Fever"" supported by the sentence: ""RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.""?",False, -25565511,Artemether affects malaria,341,Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.,"Is the triple ""Artemether affects malaria"" supported by the sentence: ""Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.""?",False, -19253720,Artemether prevents malaria,342,New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.,"Is the triple ""Artemether prevents malaria"" supported by the sentence: ""New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.""?",False, -10002115,Artemether prevents urinary schistosomiasis,343,"Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.","Is the triple ""Artemether prevents urinary schistosomiasis"" supported by the sentence: ""Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.""?",False, -8716445,Isoproterenol causes atrial fibrillation,344,"A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).","Is the triple ""Isoproterenol causes atrial fibrillation"" supported by the sentence: ""A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).""?",False, -25912644,Isoproterenol affects obstructive lung disease,345,The effect of isoproterenol on airway obstruction in cystic fibrosis.,"Is the triple ""Isoproterenol affects obstructive lung disease"" supported by the sentence: ""The effect of isoproterenol on airway obstruction in cystic fibrosis.""?",False, -24900253,Isoproterenol affects obesity disorder,346,"OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.","Is the triple ""Isoproterenol affects obesity disorder"" supported by the sentence: ""OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.""?",False, -9298156,Isoproterenol affects atrial fibrillation,347,[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].,"Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].""?",False, -7542857,Isoproterenol affects atrial fibrillation,348,"OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.","Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.""?",False, -26721271,Isoproterenol disrupts obesity disorder,349,"In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.","Is the triple ""Isoproterenol disrupts obesity disorder"" supported by the sentence: ""In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.""?",False, -7635739,Isoproterenol predisposes atrial fibrillation,350,The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.,"Is the triple ""Isoproterenol predisposes atrial fibrillation"" supported by the sentence: ""The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.""?",False, -23874783,Bacitracin A related to pneumonia,351,"These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .","Is the triple ""Bacitracin A related to pneumonia"" supported by the sentence: ""These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .""?",False, -26428368,Bacitracin A prevents bacterial infectious disease,352,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Bacitracin A prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, -18829774,Bacitracin A prevents cardiac rhythm disease,353,"The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.","Is the triple ""Bacitracin A prevents cardiac rhythm disease"" supported by the sentence: ""The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.""?",False, -16650012,Diflunisal subclass of Diflunisal glucuronide ester,354,"We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.","Is the triple ""Diflunisal subclass of Diflunisal glucuronide ester"" supported by the sentence: ""We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.""?",False, -26133976,Diflunisal causes Pain,355,"Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).","Is the triple ""Diflunisal causes Pain"" supported by the sentence: ""Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).""?",False, -26132411,Diflunisal affects Pain,356,[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].,"Is the triple ""Diflunisal affects Pain"" supported by the sentence: ""[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].""?",False, -26009871,Diflunisal affects Fever,357,"In contrast, submaximal fever in rabbits was not reduced by diflunisal.","Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""In contrast, submaximal fever in rabbits was not reduced by diflunisal.""?",False, -26009870,Diflunisal affects Fever,358,Effects of diflunisal on fever in the rabbit and the rat.,"Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""Effects of diflunisal on fever in the rabbit and the rat.""?",False, -13234484,Diflunisal affects Diflunisal glucuronide ester,359,"Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.","Is the triple ""Diflunisal affects Diflunisal glucuronide ester"" supported by the sentence: ""Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.""?",False, -14757294,Diflunisal prevents Pain,360,"It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.","Is the triple ""Diflunisal prevents Pain"" supported by the sentence: ""It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.""?",False, -17020332,Salsalate causes Insulin resistance,361,"Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.","Is the triple ""Salsalate causes Insulin resistance"" supported by the sentence: ""Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.""?",False, -21902985,Salsalate affects diabetes mellitus,362,Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.,"Is the triple ""Salsalate affects diabetes mellitus"" supported by the sentence: ""Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.""?",False, -25541729,Salsalate disrupts Insulin resistance,363,Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.,"Is the triple ""Salsalate disrupts Insulin resistance"" supported by the sentence: ""Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.""?",False, -19533984,Salsalate prevents diabetes mellitus,364,"Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.","Is the triple ""Salsalate prevents diabetes mellitus"" supported by the sentence: ""Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.""?",False, -26431050,Sodium salicylate causes Fever,365,"Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.","Is the triple ""Sodium salicylate causes Fever"" supported by the sentence: ""Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.""?",False, -11882723,Sodium salicylate affects Fever,366,A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.""?",False, -9968696,Sodium salicylate affects Fever,367,The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).""?",False, -15893532,Sodium salicylate predisposes Pain,368,Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.,"Is the triple ""Sodium salicylate predisposes Pain"" supported by the sentence: ""Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.""?",False, -7201382,Aspirin subclass of Salicylic Acid,369,"The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.","Is the triple ""Aspirin subclass of Salicylic Acid"" supported by the sentence: ""The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.""?",False, -26818861,Aspirin related to myocardial infarction,370,Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.,"Is the triple ""Aspirin related to myocardial infarction"" supported by the sentence: ""Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.""?",False, -26532873,Aspirin related to classic familial adenomatous polyposis,371,The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.,"Is the triple ""Aspirin related to classic familial adenomatous polyposis"" supported by the sentence: ""The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.""?",False, -26329928,Aspirin related to type 2 diabetes mellitus,372,Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.,"Is the triple ""Aspirin related to type 2 diabetes mellitus"" supported by the sentence: ""Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.""?",False, -26168722,Aspirin related to Inflammation,373,"The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.","Is the triple ""Aspirin related to Inflammation"" supported by the sentence: ""The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.""?",False, -24076103,Aspirin related to Hemorrhage,374,"Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.","Is the triple ""Aspirin related to Hemorrhage"" supported by the sentence: ""Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.""?",False, -20241570,Aspirin related to Pain,375,Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.,"Is the triple ""Aspirin related to Pain"" supported by the sentence: ""Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.""?",False, -18524506,Aspirin related to cataract,376,Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.,"Is the triple ""Aspirin related to cataract"" supported by the sentence: ""Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.""?",False, -18008074,Aspirin related to diabetes mellitus,377,"It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).","Is the triple ""Aspirin related to diabetes mellitus"" supported by the sentence: ""It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).""?",False, -17483160,Aspirin related to mucocutaneous lymph node syndrome,378,We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.,"Is the triple ""Aspirin related to mucocutaneous lymph node syndrome"" supported by the sentence: ""We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.""?",False, -16078277,Aspirin related to preeclampsia,379,Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.,"Is the triple ""Aspirin related to preeclampsia"" supported by the sentence: ""Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.""?",False, -15283505,Aspirin related to thrombotic disease,380,"The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.","Is the triple ""Aspirin related to thrombotic disease"" supported by the sentence: ""The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.""?",False, -13829413,Aspirin related to retinal vein occlusion,381,Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.,"Is the triple ""Aspirin related to retinal vein occlusion"" supported by the sentence: ""Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.""?",False, -13174915,Aspirin related to ST-elevation myocardial infarction,382,"The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.","Is the triple ""Aspirin related to ST-elevation myocardial infarction"" supported by the sentence: ""The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.""?",False, -12865539,Aspirin related to cardiovascular disorder,383,"METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.","Is the triple ""Aspirin related to cardiovascular disorder"" supported by the sentence: ""METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.""?",False, -12749655,Aspirin related to Salicylic Acid,384,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, -12502970,Aspirin related to coronary artery disorder,385,Low-dose aspirin and heparin in unstable coronary artery disease.,"Is the triple ""Aspirin related to coronary artery disorder"" supported by the sentence: ""Low-dose aspirin and heparin in unstable coronary artery disease.""?",False, -10635434,Aspirin related to rheumatic heart disease,386,A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.,"Is the triple ""Aspirin related to rheumatic heart disease"" supported by the sentence: ""A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.""?",False, -10534181,Aspirin related to osteoarthritis,387,"A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.","Is the triple ""Aspirin related to osteoarthritis"" supported by the sentence: ""A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.""?",False, -10473195,Aspirin related to asthma,388,"Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.","Is the triple ""Aspirin related to asthma"" supported by the sentence: ""Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.""?",False, -9315521,Aspirin related to atrial fibrillation,389,"In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.","Is the triple ""Aspirin related to atrial fibrillation"" supported by the sentence: ""In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.""?",False, -8718389,Aspirin related to stroke disorder,390,Heparin and aspirin in stroke.,"Is the triple ""Aspirin related to stroke disorder"" supported by the sentence: ""Heparin and aspirin in stroke.""?",False, -8430499,Aspirin related to Ischemic stroke,391,Heparin versus aspirin in ischaemic stroke.,"Is the triple ""Aspirin related to Ischemic stroke"" supported by the sentence: ""Heparin versus aspirin in ischaemic stroke.""?",False, -7718877,Aspirin related to acute coronary syndrome,392,"In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.","Is the triple ""Aspirin related to acute coronary syndrome"" supported by the sentence: ""In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.""?",False, -8745735,Aspirin related to Salicylic Acid,393,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, -12749656,Aspirin close match Salicylic Acid,394,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, -8745736,Aspirin close match Salicylic Acid,395,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, -10716638,Aspirin coexists with Salicylic Acid,396,An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.,"Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.""?",False, -10182446,Aspirin coexists with Salicylic Acid,397,"A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.","Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.""?",False, -8959647,Aspirin derives from Salicylic Acid,398,Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.,"Is the triple ""Aspirin derives from Salicylic Acid"" supported by the sentence: ""Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.""?",False, -7421635,Aspirin physically interacts with Salicylic Acid,399,"Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.""?",False, -9047883,Aspirin physically interacts with Salicylic Acid,400,"Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.""?",False, -27550629,Aspirin causes transient ischemic attack,401,"In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).","Is the triple ""Aspirin causes transient ischemic attack"" supported by the sentence: ""In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).""?",False, -27093984,Aspirin causes Sepsis,402,Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).,"Is the triple ""Aspirin causes Sepsis"" supported by the sentence: ""Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).""?",False, -26941889,Aspirin causes colonic neoplasm,403,"Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.","Is the triple ""Aspirin causes colonic neoplasm"" supported by the sentence: ""Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.""?",False, -26621273,Aspirin causes diabetic retinopathy,404,"Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.","Is the triple ""Aspirin causes diabetic retinopathy"" supported by the sentence: ""Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.""?",False, -25682183,Aspirin causes Toothache,405,The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.,"Is the triple ""Aspirin causes Toothache"" supported by the sentence: ""The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.""?",False, -24276147,Aspirin causes osteoarthritis,406,"The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.","Is the triple ""Aspirin causes osteoarthritis"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.""?",False, -23603605,Aspirin causes infertility disorder,407,"Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.","Is the triple ""Aspirin causes infertility disorder"" supported by the sentence: ""Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.""?",False, -22149437,Aspirin causes myocardial infarction,408,"In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.","Is the triple ""Aspirin causes myocardial infarction"" supported by the sentence: ""In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.""?",False, -21269587,Aspirin causes preeclampsia,409,This review article will contribute to the in-depth understanding of LDA-induced PE prevention.,"Is the triple ""Aspirin causes preeclampsia"" supported by the sentence: ""This review article will contribute to the in-depth understanding of LDA-induced PE prevention.""?",False, -21190178,Aspirin causes Varicose Ulcer,410,Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.,"Is the triple ""Aspirin causes Varicose Ulcer"" supported by the sentence: ""Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.""?",False, -20967677,Aspirin causes cerebral infarction,411,"The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.","Is the triple ""Aspirin causes cerebral infarction"" supported by the sentence: ""The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.""?",False, -20453125,Aspirin causes squamous cell carcinoma,412,"Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.","Is the triple ""Aspirin causes squamous cell carcinoma"" supported by the sentence: ""Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.""?",False, -20257764,Aspirin causes vascular disorder,413,Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.,"Is the triple ""Aspirin causes vascular disorder"" supported by the sentence: ""Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.""?",False, -18467493,Aspirin causes periodontitis,414,Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.,"Is the triple ""Aspirin causes periodontitis"" supported by the sentence: ""Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.""?",False, -18133593,Aspirin causes acute lung injury,415,Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.,"Is the triple ""Aspirin causes acute lung injury"" supported by the sentence: ""Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.""?",False, -17905974,Aspirin causes mucocutaneous lymph node syndrome,416,Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.,"Is the triple ""Aspirin causes mucocutaneous lymph node syndrome"" supported by the sentence: ""Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.""?",False, -16266546,Aspirin causes cardiovascular disorder,417,BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.,"Is the triple ""Aspirin causes cardiovascular disorder"" supported by the sentence: ""BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.""?",False, -15908394,Aspirin causes arthritic joint disease,418,Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.,"Is the triple ""Aspirin causes arthritic joint disease"" supported by the sentence: ""Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.""?",False, -15782733,Aspirin causes ulcerative colitis,419,Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.,"Is the triple ""Aspirin causes ulcerative colitis"" supported by the sentence: ""Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.""?",False, -15251529,Aspirin causes myocardial ischemia,420,Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.,"Is the triple ""Aspirin causes myocardial ischemia"" supported by the sentence: ""Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.""?",False, -15022291,Aspirin causes pneumonia,421,"BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.","Is the triple ""Aspirin causes pneumonia"" supported by the sentence: ""BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.""?",False, -14953515,Aspirin causes diabetes mellitus,422,"Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.","Is the triple ""Aspirin causes diabetes mellitus"" supported by the sentence: ""Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.""?",False, -14693157,Aspirin causes atrial fibrillation,423,"I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.","Is the triple ""Aspirin causes atrial fibrillation"" supported by the sentence: ""I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.""?",False, -14660024,Aspirin causes ischemic disease,424,C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.,"Is the triple ""Aspirin causes ischemic disease"" supported by the sentence: ""C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.""?",False, -14296178,Aspirin causes type 2 diabetes mellitus,425,Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.,"Is the triple ""Aspirin causes type 2 diabetes mellitus"" supported by the sentence: ""Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.""?",False, -13914591,Aspirin causes digestive system disorder,426,"Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.","Is the triple ""Aspirin causes digestive system disorder"" supported by the sentence: ""Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.""?",False, -13814866,Aspirin causes Fever,427,Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.,"Is the triple ""Aspirin causes Fever"" supported by the sentence: ""Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.""?",False, -13639281,Aspirin causes acute coronary syndrome,428,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes acute coronary syndrome"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, -13639280,Aspirin causes Ischemic stroke,429,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes Ischemic stroke"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, -13405854,Aspirin causes hypertensive disorder,430,"The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.","Is the triple ""Aspirin causes hypertensive disorder"" supported by the sentence: ""The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.""?",False, -13278968,Aspirin causes adult acute respiratory distress syndrome,431,Aspirin-induced non-cardiogenic pulmonary edema.,"Is the triple ""Aspirin causes adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin-induced non-cardiogenic pulmonary edema.""?",False, -11251562,Aspirin causes Pain,432,The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).,"Is the triple ""Aspirin causes Pain"" supported by the sentence: ""The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).""?",False, -10850020,Aspirin causes migraine disorder,433,"When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.","Is the triple ""Aspirin causes migraine disorder"" supported by the sentence: ""When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.""?",False, -10555051,Aspirin causes duodenal ulcer,434,"As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.","Is the triple ""Aspirin causes duodenal ulcer"" supported by the sentence: ""As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.""?",False, -9350599,Aspirin causes active peptic ulcer disease,435,DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.,"Is the triple ""Aspirin causes active peptic ulcer disease"" supported by the sentence: ""DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.""?",False, -9238263,Aspirin causes blood coagulation disease,436,"An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.","Is the triple ""Aspirin causes blood coagulation disease"" supported by the sentence: ""An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.""?",False, -8683872,Aspirin causes stroke disorder,437,"MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.","Is the triple ""Aspirin causes stroke disorder"" supported by the sentence: ""MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.""?",False, -8518235,Aspirin causes peptic ulcer disease,438,Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.,"Is the triple ""Aspirin causes peptic ulcer disease"" supported by the sentence: ""Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.""?",False, -8466167,Aspirin causes Headache,439,(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.,"Is the triple ""Aspirin causes Headache"" supported by the sentence: ""(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.""?",False, -8232293,Aspirin causes Hemorrhage,440,"The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.","Is the triple ""Aspirin causes Hemorrhage"" supported by the sentence: ""The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.""?",False, -7594346,Aspirin causes asthma,441,LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.,"Is the triple ""Aspirin causes asthma"" supported by the sentence: ""LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.""?",False, -7353622,Aspirin causes gastric ulcer,442,BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.,"Is the triple ""Aspirin causes gastric ulcer"" supported by the sentence: ""BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.""?",False, -7227553,Aspirin causes injury,443,"Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.","Is the triple ""Aspirin causes injury"" supported by the sentence: ""Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.""?",False, -26773149,Aspirin affects atrial fibrillation,444,Further studies are needed to clarify the role of aspirin in atrial fibrillation.,"Is the triple ""Aspirin affects atrial fibrillation"" supported by the sentence: ""Further studies are needed to clarify the role of aspirin in atrial fibrillation.""?",False, -26425353,Aspirin affects atherosclerosis,445,Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.""?",False, -26396469,Aspirin affects Dysmenorrhea,446,The effect of aspirin on dysmenorrhea in adolescents.,"Is the triple ""Aspirin affects Dysmenorrhea"" supported by the sentence: ""The effect of aspirin on dysmenorrhea in adolescents.""?",False, -25760183,Aspirin affects thrombophilia due to thrombin defect,447,Effect of aspirin on postoperative venous thrombosis.,"Is the triple ""Aspirin affects thrombophilia due to thrombin defect"" supported by the sentence: ""Effect of aspirin on postoperative venous thrombosis.""?",False, -24559876,Aspirin affects coronary artery disorder,448,"CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.","Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.""?",False, -23119254,Aspirin affects brain aneurysm,449,Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.""?",False, -21758599,Aspirin affects brain aneurysm,450,CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.""?",False, -21116359,Aspirin affects major depressive disorder,451,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, -21116358,Aspirin affects schizophrenia,452,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects schizophrenia"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, -21031382,Aspirin affects neoplasm,453,"Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.""?",False, -20857373,Aspirin affects melanoma,454,"It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.","Is the triple ""Aspirin affects melanoma"" supported by the sentence: ""It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.""?",False, -20741170,Aspirin affects fetal growth restriction,455,Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.,"Is the triple ""Aspirin affects fetal growth restriction"" supported by the sentence: ""Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.""?",False, -20453126,Aspirin affects squamous cell carcinoma,456,"To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.","Is the triple ""Aspirin affects squamous cell carcinoma"" supported by the sentence: ""To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.""?",False, -19190473,Aspirin affects acute lung injury,457,RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.,"Is the triple ""Aspirin affects acute lung injury"" supported by the sentence: ""RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.""?",False, -18874269,Aspirin affects preeclampsia,458,Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.,"Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.""?",False, -18830463,Aspirin affects Varicose Ulcer,459,"To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.","Is the triple ""Aspirin affects Varicose Ulcer"" supported by the sentence: ""To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.""?",False, -18706529,Aspirin affects mucocutaneous lymph node syndrome,460,"Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.","Is the triple ""Aspirin affects mucocutaneous lymph node syndrome"" supported by the sentence: ""Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.""?",False, -18617993,Aspirin affects Sepsis,461,"This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.","Is the triple ""Aspirin affects Sepsis"" supported by the sentence: ""This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.""?",False, -18348076,Aspirin affects Headache,462,"We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).","Is the triple ""Aspirin affects Headache"" supported by the sentence: ""We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).""?",False, -18344374,Aspirin affects bone fracture,463,This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.,"Is the triple ""Aspirin affects bone fracture"" supported by the sentence: ""This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.""?",False, -18277701,Aspirin affects adult acute respiratory distress syndrome,464,"Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.","Is the triple ""Aspirin affects adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.""?",False, -18092588,Aspirin affects Fever,465,"Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.""?",False, -17810437,Aspirin affects migraine disorder,466,"Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.","Is the triple ""Aspirin affects migraine disorder"" supported by the sentence: ""Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.""?",False, -16655533,Aspirin affects stroke disorder,467,Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.""?",False, -16466986,Aspirin affects myocardial ischemia,468,Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).""?",False, -16123563,Aspirin affects digestive system disorder,469,[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].,"Is the triple ""Aspirin affects digestive system disorder"" supported by the sentence: ""[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].""?",False, -15829936,Aspirin affects hypertriglyceridemia,470,Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.,"Is the triple ""Aspirin affects hypertriglyceridemia"" supported by the sentence: ""Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.""?",False, -15667690,Aspirin affects hepatocellular carcinoma,471,Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.,"Is the triple ""Aspirin affects hepatocellular carcinoma"" supported by the sentence: ""Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.""?",False, -15311732,Aspirin affects periodontitis,472,"METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.","Is the triple ""Aspirin affects periodontitis"" supported by the sentence: ""METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.""?",False, -15094783,Aspirin affects diabetic retinopathy,473,Effects of aspirin treatment on diabetic retinopathy.,"Is the triple ""Aspirin affects diabetic retinopathy"" supported by the sentence: ""Effects of aspirin treatment on diabetic retinopathy.""?",False, -13831910,Aspirin affects gastric ulcer,474,The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.,"Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.""?",False, -13734334,Aspirin affects Pregnancy,475,"There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.","Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.""?",False, -13647977,Aspirin affects neoplasm,476,"We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.""?",False, -13624111,Aspirin affects pneumonia,477,OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.,"Is the triple ""Aspirin affects pneumonia"" supported by the sentence: ""OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.""?",False, -13559011,Aspirin affects type 2 diabetes mellitus,478,"Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.","Is the triple ""Aspirin affects type 2 diabetes mellitus"" supported by the sentence: ""Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.""?",False, -13493823,Aspirin affects thrombotic disease,479,Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.,"Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.""?",False, -12884495,Aspirin affects duodenal ulcer,480,"Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.","Is the triple ""Aspirin affects duodenal ulcer"" supported by the sentence: ""Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.""?",False, -12815469,Aspirin affects atherosclerosis,481,Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.""?",False, -12769418,Aspirin affects active peptic ulcer disease,482,The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.""?",False, -12607959,Aspirin affects plasma cell myeloma,483,Does low-dose aspirin have antineoplastic effects in multiple myeloma?,"Is the triple ""Aspirin affects plasma cell myeloma"" supported by the sentence: ""Does low-dose aspirin have antineoplastic effects in multiple myeloma?""?",False, -12446363,Aspirin affects hypertensive disorder,484,Diabetes mellitus and hypertension are relative risk factors of AR and ASR.,"Is the triple ""Aspirin affects hypertensive disorder"" supported by the sentence: ""Diabetes mellitus and hypertension are relative risk factors of AR and ASR.""?",False, -12124867,Aspirin affects heart disorder,485,Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.,"Is the triple ""Aspirin affects heart disorder"" supported by the sentence: ""Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.""?",False, -11661767,Aspirin affects peptic ulcer disease,486,"CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.""?",False, -11474111,Aspirin affects diabetes mellitus,487,We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.,"Is the triple ""Aspirin affects diabetes mellitus"" supported by the sentence: ""We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.""?",False, -11357781,Aspirin affects ischemic disease,488,Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.,"Is the triple ""Aspirin affects ischemic disease"" supported by the sentence: ""Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.""?",False, -11341534,Aspirin affects ulcer disease,489,"Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.""?",False, -11135514,Aspirin affects cerebrovascular disorder,490,Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.,"Is the triple ""Aspirin affects cerebrovascular disorder"" supported by the sentence: ""Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.""?",False, -10875862,Aspirin affects acquired polycythemia vera,491,"Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.","Is the triple ""Aspirin affects acquired polycythemia vera"" supported by the sentence: ""Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.""?",False, -10830878,Aspirin affects Inflammation,492,"These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.""?",False, -10337669,Aspirin affects colorectal neoplasm,493,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Aspirin affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, -10331252,Aspirin affects peptic ulcer disease,494,"Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.""?",False, -10226347,Aspirin affects thrombophilia,495,"Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.","Is the triple ""Aspirin affects thrombophilia"" supported by the sentence: ""Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.""?",False, -10082315,Aspirin affects Pain,496,"Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.","Is the triple ""Aspirin affects Pain"" supported by the sentence: ""Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.""?",False, -10068618,Aspirin affects adenoma,497,CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.,"Is the triple ""Aspirin affects adenoma"" supported by the sentence: ""CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.""?",False, -9766251,Aspirin affects injury,498,Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.,"Is the triple ""Aspirin affects injury"" supported by the sentence: ""Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.""?",False, -9581221,Aspirin affects cataract,499,"Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.","Is the triple ""Aspirin affects cataract"" supported by the sentence: ""Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.""?",False, -9528323,Aspirin affects asthma,500,We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).,"Is the triple ""Aspirin affects asthma"" supported by the sentence: ""We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).""?",False, -9510044,Aspirin affects transient ischemic attack,501,This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.,"Is the triple ""Aspirin affects transient ischemic attack"" supported by the sentence: ""This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.""?",False, -9342553,Aspirin affects Salicylic Acid,502,"METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.""?",False, -9259288,Aspirin affects Fever,503,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, -9203900,Aspirin affects Hypercholesterolemia,504,This action of aspirin is blunted in hypercholesterolemia.,"Is the triple ""Aspirin affects Hypercholesterolemia"" supported by the sentence: ""This action of aspirin is blunted in hypercholesterolemia.""?",False, -9160463,Aspirin affects gastric ulcer,505,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.","Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.""?",False, -9084341,Aspirin affects Ischemic stroke,506,A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.,"Is the triple ""Aspirin affects Ischemic stroke"" supported by the sentence: ""A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.""?",False, -8650258,Aspirin affects Hemorrhage,507,"CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.""?",False, -8543326,Aspirin affects active peptic ulcer disease,508,OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.""?",False, -8290962,Aspirin affects ulcer disease,509,"Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.""?",False, -8187935,Aspirin affects injury,510,"Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.","Is the triple ""Aspirin affects injury"" supported by the sentence: ""Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.""?",False, -8173134,Aspirin affects thrombotic disease,511,"These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.","Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.""?",False, -8169760,Aspirin affects preeclampsia,512,"These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.","Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.""?",False, -7935107,Aspirin affects prostate cancer,513,"Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.","Is the triple ""Aspirin affects prostate cancer"" supported by the sentence: ""Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.""?",False, -7920712,Aspirin affects Hemorrhage,514,"After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.""?",False, -7876600,Aspirin affects Hemorrhage,515,"CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.""?",False, -7820545,Aspirin affects vascular disorder,516,The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.,"Is the triple ""Aspirin affects vascular disorder"" supported by the sentence: ""The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.""?",False, -7816175,Aspirin affects Pregnancy,517,L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.,"Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.""?",False, -7635677,Aspirin affects myocardial ischemia,518,We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.""?",False, -7478885,Aspirin affects coronary artery disorder,519,Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.,"Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.""?",False, -7468514,Aspirin affects stroke disorder,520,A metaregression analysis of the dose-response effect of aspirin on stroke.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""A metaregression analysis of the dose-response effect of aspirin on stroke.""?",False, -7251569,Aspirin affects myocardial infarction,521,A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.,"Is the triple ""Aspirin affects myocardial infarction"" supported by the sentence: ""A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.""?",False, -7213554,Aspirin affects cardiovascular disorder,522,"The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.","Is the triple ""Aspirin affects cardiovascular disorder"" supported by the sentence: ""The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.""?",False, -7156429,Aspirin affects Inflammation,523,"The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.""?",False, -14159165,Aspirin affects Salicylic Acid,524,"According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.""?",False, -27335099,Aspirin disrupts thrombophilia due to thrombin defect,525,"In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.","Is the triple ""Aspirin disrupts thrombophilia due to thrombin defect"" supported by the sentence: ""In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.""?",False, -24958273,Aspirin disrupts Fever,526,"In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.","Is the triple ""Aspirin disrupts Fever"" supported by the sentence: ""In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.""?",False, -24520178,Aspirin disrupts melanoma,527,"However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).","Is the triple ""Aspirin disrupts melanoma"" supported by the sentence: ""However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).""?",False, -24047967,Aspirin disrupts cardiovascular disorder,528,"Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.","Is the triple ""Aspirin disrupts cardiovascular disorder"" supported by the sentence: ""Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.""?",False, -22107293,Aspirin disrupts atrial fibrillation,529,Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.,"Is the triple ""Aspirin disrupts atrial fibrillation"" supported by the sentence: ""Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.""?",False, -22100738,Aspirin disrupts fetal growth restriction,530,"Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.","Is the triple ""Aspirin disrupts fetal growth restriction"" supported by the sentence: ""Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.""?",False, -22027792,Aspirin disrupts venous thromboembolism,531,Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.,"Is the triple ""Aspirin disrupts venous thromboembolism"" supported by the sentence: ""Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.""?",False, -21434441,Aspirin disrupts thrombophilia,532,"Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.","Is the triple ""Aspirin disrupts thrombophilia"" supported by the sentence: ""Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.""?",False, -20385507,Aspirin disrupts essential thrombocythemia,533,"However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.","Is the triple ""Aspirin disrupts essential thrombocythemia"" supported by the sentence: ""However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.""?",False, -19437129,Aspirin disrupts Sepsis,534,"This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).","Is the triple ""Aspirin disrupts Sepsis"" supported by the sentence: ""This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).""?",False, -19421638,Aspirin disrupts pneumonia,535,"CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.","Is the triple ""Aspirin disrupts pneumonia"" supported by the sentence: ""CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.""?",False, -19318532,Aspirin disrupts vascular disorder,536,These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.,"Is the triple ""Aspirin disrupts vascular disorder"" supported by the sentence: ""These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.""?",False, -18604728,Aspirin disrupts type 2 diabetes mellitus,537,"Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.","Is the triple ""Aspirin disrupts type 2 diabetes mellitus"" supported by the sentence: ""Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.""?",False, -18599969,Aspirin disrupts arthritic joint disease,538,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.","Is the triple ""Aspirin disrupts arthritic joint disease"" supported by the sentence: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?",False, -18445880,Aspirin disrupts ovarian cancer,539,"Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.","Is the triple ""Aspirin disrupts ovarian cancer"" supported by the sentence: ""Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.""?",False, -18225861,Aspirin disrupts Hemorrhage,540,"Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.","Is the triple ""Aspirin disrupts Hemorrhage"" supported by the sentence: ""Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.""?",False, -18203584,Aspirin disrupts brain aneurysm,541,Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.,"Is the triple ""Aspirin disrupts brain aneurysm"" supported by the sentence: ""Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.""?",False, -17476286,Aspirin disrupts Fatigue,542,"In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.","Is the triple ""Aspirin disrupts Fatigue"" supported by the sentence: ""In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.""?",False, -17225706,Aspirin disrupts transient ischemic attack,543,The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.,"Is the triple ""Aspirin disrupts transient ischemic attack"" supported by the sentence: ""The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.""?",False, -16676314,Aspirin disrupts ulcer disease,544,"Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.","Is the triple ""Aspirin disrupts ulcer disease"" supported by the sentence: ""Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.""?",False, -16484307,Aspirin disrupts acute lung injury,545,"METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.","Is the triple ""Aspirin disrupts acute lung injury"" supported by the sentence: ""METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.""?",False, -14296080,Aspirin disrupts Pregnancy,546,"Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.","Is the triple ""Aspirin disrupts Pregnancy"" supported by the sentence: ""Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.""?",False, -14068900,Aspirin disrupts active peptic ulcer disease,547,"In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.","Is the triple ""Aspirin disrupts active peptic ulcer disease"" supported by the sentence: ""In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.""?",False, -13892678,Aspirin disrupts breast neoplasm,548,Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.,"Is the triple ""Aspirin disrupts breast neoplasm"" supported by the sentence: ""Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.""?",False, -13449558,Aspirin disrupts colorectal neoplasm,549,"BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.","Is the triple ""Aspirin disrupts colorectal neoplasm"" supported by the sentence: ""BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.""?",False, -12947740,Aspirin disrupts diabetic retinopathy,550,"It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.","Is the triple ""Aspirin disrupts diabetic retinopathy"" supported by the sentence: ""It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.""?",False, -12815470,Aspirin disrupts atherosclerosis,551,"CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.","Is the triple ""Aspirin disrupts atherosclerosis"" supported by the sentence: ""CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.""?",False, -12714476,Aspirin disrupts cataract,552,Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.,"Is the triple ""Aspirin disrupts cataract"" supported by the sentence: ""Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.""?",False, -12478523,Aspirin disrupts preeclampsia,553,Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?,"Is the triple ""Aspirin disrupts preeclampsia"" supported by the sentence: ""Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?""?",False, -12450426,Aspirin disrupts Barrett esophagus,554,"Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].","Is the triple ""Aspirin disrupts Barrett esophagus"" supported by the sentence: ""Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].""?",False, -12023670,Aspirin disrupts hypertensive disorder,555,The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.,"Is the triple ""Aspirin disrupts hypertensive disorder"" supported by the sentence: ""The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.""?",False, -11827133,Aspirin disrupts diabetes mellitus,556,"Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.","Is the triple ""Aspirin disrupts diabetes mellitus"" supported by the sentence: ""Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.""?",False, -10318928,Aspirin disrupts Myalgia,557,"RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).","Is the triple ""Aspirin disrupts Myalgia"" supported by the sentence: ""RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).""?",False, -9742254,Aspirin disrupts adenoma,558,"BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.","Is the triple ""Aspirin disrupts adenoma"" supported by the sentence: ""BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.""?",False, -9148614,Aspirin disrupts neoplasm,559,"Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.","Is the triple ""Aspirin disrupts neoplasm"" supported by the sentence: ""Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.""?",False, -8526818,Aspirin disrupts myocardial infarction,560,"Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).","Is the triple ""Aspirin disrupts myocardial infarction"" supported by the sentence: ""Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).""?",False, -7995298,Aspirin disrupts Inflammation,561,RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.,"Is the triple ""Aspirin disrupts Inflammation"" supported by the sentence: ""RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.""?",False, -7878103,Aspirin disrupts prostate cancer,562,"Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).","Is the triple ""Aspirin disrupts prostate cancer"" supported by the sentence: ""Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).""?",False, -7775480,Aspirin disrupts Pain,563,"The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.","Is the triple ""Aspirin disrupts Pain"" supported by the sentence: ""The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.""?",False, -7723340,Aspirin disrupts stroke disorder,564,"Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.","Is the triple ""Aspirin disrupts stroke disorder"" supported by the sentence: ""Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.""?",False, -7712646,Aspirin disrupts coronary artery disorder,565,Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.,"Is the triple ""Aspirin disrupts coronary artery disorder"" supported by the sentence: ""Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.""?",False, -7261879,Aspirin disrupts thrombotic disease,566,"In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.","Is the triple ""Aspirin disrupts thrombotic disease"" supported by the sentence: ""In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.""?",False, -24597938,Aspirin prevents thrombophilia,567,Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.,"Is the triple ""Aspirin prevents thrombophilia"" supported by the sentence: ""Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.""?",False, -24091248,Aspirin prevents disseminated intravascular coagulation,568,Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.,"Is the triple ""Aspirin prevents disseminated intravascular coagulation"" supported by the sentence: ""Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.""?",False, -24015329,Aspirin prevents neoplasm of esophagus,569,"Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.","Is the triple ""Aspirin prevents neoplasm of esophagus"" supported by the sentence: ""Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.""?",False, -23042755,Aspirin prevents brain aneurysm,570,BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.,"Is the triple ""Aspirin prevents brain aneurysm"" supported by the sentence: ""BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.""?",False, -22291835,Aspirin prevents Hemorrhage,571,"CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.","Is the triple ""Aspirin prevents Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.""?",False, -21962376,Aspirin prevents venous thromboembolism,572,Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.,"Is the triple ""Aspirin prevents venous thromboembolism"" supported by the sentence: ""Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.""?",False, -21587985,Aspirin prevents blood coagulation disease,573,Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.,"Is the triple ""Aspirin prevents blood coagulation disease"" supported by the sentence: ""Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.""?",False, -21116357,Aspirin prevents schizophrenia,574,The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.,"Is the triple ""Aspirin prevents schizophrenia"" supported by the sentence: ""The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.""?",False, -20356983,Aspirin prevents acute lung injury,575,"Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).","Is the triple ""Aspirin prevents acute lung injury"" supported by the sentence: ""Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).""?",False, -20189716,Aspirin prevents brain infarction,576,"We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.","Is the triple ""Aspirin prevents brain infarction"" supported by the sentence: ""We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.""?",False, -18414184,Aspirin prevents multiple sclerosis,577,"Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.","Is the triple ""Aspirin prevents multiple sclerosis"" supported by the sentence: ""Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.""?",False, -18344373,Aspirin prevents bone fracture,578,"If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.","Is the triple ""Aspirin prevents bone fracture"" supported by the sentence: ""If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.""?",False, -17911903,Aspirin prevents adult acute respiratory distress syndrome,579,"Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.","Is the triple ""Aspirin prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.""?",False, -17240995,Aspirin prevents hepatocellular carcinoma,580,Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).,"Is the triple ""Aspirin prevents hepatocellular carcinoma"" supported by the sentence: ""Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).""?",False, -16163718,Aspirin prevents Sepsis,581,The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.,"Is the triple ""Aspirin prevents Sepsis"" supported by the sentence: ""The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.""?",False, -15608454,Aspirin prevents squamous cell carcinoma,582,"CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.","Is the triple ""Aspirin prevents squamous cell carcinoma"" supported by the sentence: ""CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.""?",False, -14796348,Aspirin prevents arthritic joint disease,583,"Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.","Is the triple ""Aspirin prevents arthritic joint disease"" supported by the sentence: ""Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.""?",False, -14183452,Aspirin prevents pneumonia,584,Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.,"Is the triple ""Aspirin prevents pneumonia"" supported by the sentence: ""Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.""?",False, -13992680,Aspirin prevents diabetes mellitus,585,We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.,"Is the triple ""Aspirin prevents diabetes mellitus"" supported by the sentence: ""We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.""?",False, -13992679,Aspirin prevents type 2 diabetes mellitus,586,CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.,"Is the triple ""Aspirin prevents type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.""?",False, -13770407,Aspirin prevents diabetic retinopathy,587,"According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.","Is the triple ""Aspirin prevents diabetic retinopathy"" supported by the sentence: ""According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.""?",False, -13624060,Aspirin prevents injury,588,The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.,"Is the triple ""Aspirin prevents injury"" supported by the sentence: ""The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.""?",False, -13536062,Aspirin prevents non-small cell lung carcinoma,589,CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.,"Is the triple ""Aspirin prevents non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.""?",False, -13041448,Aspirin prevents atrial fibrillation,590,"Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.","Is the triple ""Aspirin prevents atrial fibrillation"" supported by the sentence: ""Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.""?",False, -12791249,Aspirin prevents asthma,591,"CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.","Is the triple ""Aspirin prevents asthma"" supported by the sentence: ""CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.""?",False, -12594676,Aspirin prevents Fatigue,592,Aspirin reduces MS fatigue in some patients.,"Is the triple ""Aspirin prevents Fatigue"" supported by the sentence: ""Aspirin reduces MS fatigue in some patients.""?",False, -12361944,Aspirin prevents active peptic ulcer disease,593,CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.,"Is the triple ""Aspirin prevents active peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.""?",False, -12273189,Aspirin prevents Myalgia,594,BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.,"Is the triple ""Aspirin prevents Myalgia"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.""?",False, -11593026,Aspirin prevents colorectal neoplasm,595,Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.,"Is the triple ""Aspirin prevents colorectal neoplasm"" supported by the sentence: ""Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.""?",False, -11289178,Aspirin prevents migraine disorder,596,"The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.","Is the triple ""Aspirin prevents migraine disorder"" supported by the sentence: ""The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.""?",False, -11042545,Aspirin prevents Barrett esophagus,597,"BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.","Is the triple ""Aspirin prevents Barrett esophagus"" supported by the sentence: ""BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.""?",False, -10366572,Aspirin prevents cerebrovascular disorder,598,"Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.","Is the triple ""Aspirin prevents cerebrovascular disorder"" supported by the sentence: ""Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.""?",False, -10293726,Aspirin prevents prostate cancer,599,"The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.","Is the triple ""Aspirin prevents prostate cancer"" supported by the sentence: ""The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.""?",False, -10185706,Aspirin prevents colonic neoplasm,600,Can resistant starch and/or aspirin prevent the development of colonic neoplasia?,"Is the triple ""Aspirin prevents colonic neoplasm"" supported by the sentence: ""Can resistant starch and/or aspirin prevent the development of colonic neoplasia?""?",False, -10099399,Aspirin prevents atherosclerosis,601,Aspirin treatment reduced the development of atherosclerosis by approximately 47%.,"Is the triple ""Aspirin prevents atherosclerosis"" supported by the sentence: ""Aspirin treatment reduced the development of atherosclerosis by approximately 47%.""?",False, -10096705,Aspirin prevents cerebral infarction,602,"Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.","Is the triple ""Aspirin prevents cerebral infarction"" supported by the sentence: ""Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.""?",False, -10004143,Aspirin prevents blindness (disorder),603,"Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.","Is the triple ""Aspirin prevents blindness (disorder)"" supported by the sentence: ""Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.""?",False, -9665356,Aspirin prevents hypertensive disorder,604,CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.,"Is the triple ""Aspirin prevents hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.""?",False, -9388878,Aspirin prevents coronary artery disorder,605,[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].,"Is the triple ""Aspirin prevents coronary artery disorder"" supported by the sentence: ""[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].""?",False, -9150304,Aspirin prevents habitual spontaneous abortion,606,"Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.","Is the triple ""Aspirin prevents habitual spontaneous abortion"" supported by the sentence: ""Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.""?",False, -8853513,Aspirin prevents gastric ulcer,607,"All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.","Is the triple ""Aspirin prevents gastric ulcer"" supported by the sentence: ""All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.""?",False, -8755758,Aspirin prevents vascular disorder,608,"Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.","Is the triple ""Aspirin prevents vascular disorder"" supported by the sentence: ""Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.""?",False, -8494726,Aspirin prevents ulcer disease,609,"Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.","Is the triple ""Aspirin prevents ulcer disease"" supported by the sentence: ""Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.""?",False, -8347839,Aspirin prevents peptic ulcer disease,610,"METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.","Is the triple ""Aspirin prevents peptic ulcer disease"" supported by the sentence: ""METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.""?",False, -8325441,Aspirin prevents ischemic disease,611,Peri-operative aspirin can prevent post-operative ischemia and thrombosis.,"Is the triple ""Aspirin prevents ischemic disease"" supported by the sentence: ""Peri-operative aspirin can prevent post-operative ischemia and thrombosis.""?",False, -7877588,Aspirin prevents cardiovascular disorder,612,"METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.","Is the triple ""Aspirin prevents cardiovascular disorder"" supported by the sentence: ""METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.""?",False, -7852267,Aspirin prevents Headache,613,"Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.","Is the triple ""Aspirin prevents Headache"" supported by the sentence: ""Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.""?",False, -7716613,Aspirin prevents neoplasm,614,"Furthermore, aspirin decreased the total tumors (P < 0.05).","Is the triple ""Aspirin prevents neoplasm"" supported by the sentence: ""Furthermore, aspirin decreased the total tumors (P < 0.05).""?",False, -7603499,Aspirin prevents myocardial ischemia,615,Low dose warfarin and aspirin in preventing IHD.,"Is the triple ""Aspirin prevents myocardial ischemia"" supported by the sentence: ""Low dose warfarin and aspirin in preventing IHD.""?",False, -7487700,Aspirin prevents Inflammation,616,"Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.","Is the triple ""Aspirin prevents Inflammation"" supported by the sentence: ""Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.""?",False, -7457050,Aspirin prevents peripheral vascular disease,617,"Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.","Is the triple ""Aspirin prevents peripheral vascular disease"" supported by the sentence: ""Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.""?",False, -7455467,Aspirin prevents Ischemic stroke,618,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents Ischemic stroke"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, -7455466,Aspirin prevents stroke disorder,619,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents stroke disorder"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, -7455465,Aspirin prevents transient ischemic attack,620,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents transient ischemic attack"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, -7419265,Aspirin prevents heart disorder,621,"RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.","Is the triple ""Aspirin prevents heart disorder"" supported by the sentence: ""RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.""?",False, -7368248,Aspirin prevents thrombotic disease,622,Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.,"Is the triple ""Aspirin prevents thrombotic disease"" supported by the sentence: ""Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.""?",False, -7317027,Aspirin prevents preeclampsia,623,Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.,"Is the triple ""Aspirin prevents preeclampsia"" supported by the sentence: ""Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.""?",False, -7275741,Aspirin prevents acute coronary syndrome,624,"CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.","Is the triple ""Aspirin prevents acute coronary syndrome"" supported by the sentence: ""CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.""?",False, -7264064,Aspirin prevents Pain,625,Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.,"Is the triple ""Aspirin prevents Pain"" supported by the sentence: ""Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.""?",False, -7196018,Aspirin prevents myocardial infarction,626,"BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.","Is the triple ""Aspirin prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.""?",False, -7159192,Aspirin prevents fetal growth restriction,627,"If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.","Is the triple ""Aspirin prevents fetal growth restriction"" supported by the sentence: ""If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.""?",False, -7110859,Aspirin prevents thrombophilia due to thrombin defect,628,[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].,"Is the triple ""Aspirin prevents thrombophilia due to thrombin defect"" supported by the sentence: ""[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].""?",False, -22126985,Aspirin exacerbates gastric ulcer,629,"Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.","Is the triple ""Aspirin exacerbates gastric ulcer"" supported by the sentence: ""Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.""?",False, -21411566,Aspirin exacerbates macular degeneration,630,Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?,"Is the triple ""Aspirin exacerbates macular degeneration"" supported by the sentence: ""Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?""?",False, -21359197,Aspirin exacerbates acute coronary syndrome,631,Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.,"Is the triple ""Aspirin exacerbates acute coronary syndrome"" supported by the sentence: ""Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.""?",False, -26115547,Aspirin predisposes cerebral infarction,632,"Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.","Is the triple ""Aspirin predisposes cerebral infarction"" supported by the sentence: ""Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.""?",False, -25254777,Aspirin predisposes essential thrombocythemia,633,"Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.","Is the triple ""Aspirin predisposes essential thrombocythemia"" supported by the sentence: ""Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.""?",False, -23315977,Aspirin predisposes brain aneurysm,634,The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.,"Is the triple ""Aspirin predisposes brain aneurysm"" supported by the sentence: ""The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.""?",False, -21525767,Aspirin predisposes Fever,635,Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).,"Is the triple ""Aspirin predisposes Fever"" supported by the sentence: ""Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).""?",False, -21487721,Aspirin predisposes Hemorrhage,636,"The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).","Is the triple ""Aspirin predisposes Hemorrhage"" supported by the sentence: ""The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).""?",False, -20679052,Aspirin predisposes blood coagulation disease,637,"Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.","Is the triple ""Aspirin predisposes blood coagulation disease"" supported by the sentence: ""Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.""?",False, -20234206,Aspirin predisposes hepatocellular carcinoma,638,The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.,"Is the triple ""Aspirin predisposes hepatocellular carcinoma"" supported by the sentence: ""The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.""?",False, -20155873,Aspirin predisposes placental insufficiency,639,"There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.","Is the triple ""Aspirin predisposes placental insufficiency"" supported by the sentence: ""There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.""?",False, -19346376,Aspirin predisposes chronic renal failure syndrome,640,The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.,"Is the triple ""Aspirin predisposes chronic renal failure syndrome"" supported by the sentence: ""The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.""?",False, -18235965,Aspirin predisposes macular degeneration,641,[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].,"Is the triple ""Aspirin predisposes macular degeneration"" supported by the sentence: ""[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].""?",False, -17872103,Aspirin predisposes atrial fibrillation,642,"The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.","Is the triple ""Aspirin predisposes atrial fibrillation"" supported by the sentence: ""The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.""?",False, -17123250,Aspirin predisposes acute coronary syndrome,643,"In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.","Is the triple ""Aspirin predisposes acute coronary syndrome"" supported by the sentence: ""In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.""?",False, -16813141,Aspirin predisposes melanoma,644,"In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.","Is the triple ""Aspirin predisposes melanoma"" supported by the sentence: ""In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.""?",False, -16162173,Aspirin predisposes ulcerative colitis,645,"Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.","Is the triple ""Aspirin predisposes ulcerative colitis"" supported by the sentence: ""Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.""?",False, -15461534,Aspirin predisposes gastric ulcer,646,Aspirin specifically predisposes to gastric ulcer.,"Is the triple ""Aspirin predisposes gastric ulcer"" supported by the sentence: ""Aspirin specifically predisposes to gastric ulcer.""?",False, -14856258,Aspirin predisposes neoplasm of esophagus,647,"BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.","Is the triple ""Aspirin predisposes neoplasm of esophagus"" supported by the sentence: ""BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.""?",False, -14426809,Aspirin predisposes neoplasm,648,NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.,"Is the triple ""Aspirin predisposes neoplasm"" supported by the sentence: ""NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.""?",False, -14234947,Aspirin predisposes diabetes mellitus,649,"This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.","Is the triple ""Aspirin predisposes diabetes mellitus"" supported by the sentence: ""This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.""?",False, -14126301,Aspirin predisposes cerebrovascular disorder,650,"We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).","Is the triple ""Aspirin predisposes cerebrovascular disorder"" supported by the sentence: ""We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).""?",False, -14052964,Aspirin predisposes Inflammation,651,"Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).","Is the triple ""Aspirin predisposes Inflammation"" supported by the sentence: ""Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).""?",False, -14015029,Aspirin predisposes transient ischemic attack,652,"When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.","Is the triple ""Aspirin predisposes transient ischemic attack"" supported by the sentence: ""When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.""?",False, -13644771,Aspirin predisposes asthma,653,A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.,"Is the triple ""Aspirin predisposes asthma"" supported by the sentence: ""A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.""?",False, -13536064,Aspirin predisposes non-small cell lung carcinoma,654,Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.,"Is the triple ""Aspirin predisposes non-small cell lung carcinoma"" supported by the sentence: ""Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.""?",False, -13299957,Aspirin predisposes ovarian cancer,655,Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.,"Is the triple ""Aspirin predisposes ovarian cancer"" supported by the sentence: ""Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.""?",False, -12673405,Aspirin predisposes bone fracture,656,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Aspirin predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, -12382415,Aspirin predisposes colorectal neoplasm,657,"AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Aspirin predisposes colorectal neoplasm"" supported by the sentence: ""AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).""?",False, -11071059,Aspirin predisposes injury,658,"Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.","Is the triple ""Aspirin predisposes injury"" supported by the sentence: ""Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.""?",False, -10962122,Aspirin predisposes ischemic disease,659,"The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.","Is the triple ""Aspirin predisposes ischemic disease"" supported by the sentence: ""The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.""?",False, -10547299,Aspirin predisposes coronary artery disorder,660,"Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.","Is the triple ""Aspirin predisposes coronary artery disorder"" supported by the sentence: ""Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.""?",False, -10337650,Aspirin predisposes adenoma,661,CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.,"Is the triple ""Aspirin predisposes adenoma"" supported by the sentence: ""CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.""?",False, -9857077,Aspirin predisposes vascular disorder,662,"Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.","Is the triple ""Aspirin predisposes vascular disorder"" supported by the sentence: ""Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.""?",False, -9535755,Aspirin predisposes thrombotic disease,663,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes thrombotic disease"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, -9535754,Aspirin predisposes hypertensive disorder,664,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes hypertensive disorder"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, -9491661,Aspirin predisposes cardiovascular disorder,665,"In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).","Is the triple ""Aspirin predisposes cardiovascular disorder"" supported by the sentence: ""In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).""?",False, -9477464,Aspirin predisposes prostate cancer,666,"Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).","Is the triple ""Aspirin predisposes prostate cancer"" supported by the sentence: ""Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).""?",False, -9404829,Aspirin predisposes ulcer disease,667,"Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.","Is the triple ""Aspirin predisposes ulcer disease"" supported by the sentence: ""Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.""?",False, -8850172,Aspirin predisposes myocardial ischemia,668,"Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.","Is the triple ""Aspirin predisposes myocardial ischemia"" supported by the sentence: ""Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.""?",False, -8763743,Aspirin predisposes thrombophilia due to thrombin defect,669,The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.,"Is the triple ""Aspirin predisposes thrombophilia due to thrombin defect"" supported by the sentence: ""The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.""?",False, -8545255,Aspirin predisposes Ischemic stroke,670,"When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.","Is the triple ""Aspirin predisposes Ischemic stroke"" supported by the sentence: ""When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.""?",False, -7865543,Aspirin predisposes Headache,671,We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.,"Is the triple ""Aspirin predisposes Headache"" supported by the sentence: ""We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.""?",False, -7858710,Aspirin predisposes myocardial infarction,672,"In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.","Is the triple ""Aspirin predisposes myocardial infarction"" supported by the sentence: ""In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.""?",False, -7667039,Aspirin predisposes preeclampsia,673,"However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.","Is the triple ""Aspirin predisposes preeclampsia"" supported by the sentence: ""However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.""?",False, -7659453,Aspirin predisposes stroke disorder,674,RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.,"Is the triple ""Aspirin predisposes stroke disorder"" supported by the sentence: ""RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.""?",False, -7653535,Aspirin predisposes peptic ulcer disease,675,"BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.","Is the triple ""Aspirin predisposes peptic ulcer disease"" supported by the sentence: ""BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.""?",False, -7596288,Aspirin predisposes atherosclerosis,676,"OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.","Is the triple ""Aspirin predisposes atherosclerosis"" supported by the sentence: ""OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.""?",False, -7078619,Aspirin predisposes active peptic ulcer disease,677,Risk of major gastrointestinal bleeding with aspirin.,"Is the triple ""Aspirin predisposes active peptic ulcer disease"" supported by the sentence: ""Risk of major gastrointestinal bleeding with aspirin.""?",False, -23297288,Vemurafenib prevents neoplasm,678,Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.,"Is the triple ""Vemurafenib prevents neoplasm"" supported by the sentence: ""Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.""?",False, -22851133,Dabrafenib related to melanoma,679,"KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.","Is the triple ""Dabrafenib related to melanoma"" supported by the sentence: ""KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.""?",False, -18622575,Sodium heparin related to PROTAMINE SULFATE,680,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, -18622575,Sodium heparin related to PROTAMINE SULFATE,681,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, -26359747,Sodium heparin related to PROTAMINE SULFATE,682,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, -26359747,Sodium heparin related to PROTAMINE SULFATE,683,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, -24697302,Sodium heparin has part PROTAMINE SULFATE,684,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, -24697302,Sodium heparin has part PROTAMINE SULFATE,685,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, -10513644,Sodium heparin coexists with PROTAMINE SULFATE,686,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, -10513644,Sodium heparin coexists with PROTAMINE SULFATE,687,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, -15306394,Sodium heparin coexists with PROTAMINE SULFATE,688,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, -15306394,Sodium heparin coexists with PROTAMINE SULFATE,689,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, -10518221,Sodium heparin physically interacts with PROTAMINE SULFATE,690,[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].""?",False, -9906740,Sodium heparin physically interacts with PROTAMINE SULFATE,691,Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.""?",False, -8278260,Sodium heparin affects PROTAMINE SULFATE,692,Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.,"Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.""?",False, -9085295,Sodium heparin affects PROTAMINE SULFATE,693,"One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.","Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.""?",False, -25915149,Sodium monofluorophosphate related to dental caries,694,The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.,"Is the triple ""Sodium monofluorophosphate related to dental caries"" supported by the sentence: ""The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.""?",False, -25861359,Sodium monofluorophosphate disrupts allergic disease,695,Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.,"Is the triple ""Sodium monofluorophosphate disrupts allergic disease"" supported by the sentence: ""Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.""?",False, -19241020,Sodium Fluoride related to gingivitis,696,This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.,"Is the triple ""Sodium Fluoride related to gingivitis"" supported by the sentence: ""This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.""?",False, -17448182,Sodium Fluoride related to aortic valve stenosis,697,BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.,"Is the triple ""Sodium Fluoride related to aortic valve stenosis"" supported by the sentence: ""BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.""?",False, -9111981,Sodium Fluoride related to dental caries,698,This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.,"Is the triple ""Sodium Fluoride related to dental caries"" supported by the sentence: ""This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.""?",False, -25583763,Sodium Fluoride causes dental fluorosis,699,"The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.","Is the triple ""Sodium Fluoride causes dental fluorosis"" supported by the sentence: ""The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.""?",False, -23780312,Sodium Fluoride affects dental caries,700,OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.,"Is the triple ""Sodium Fluoride affects dental caries"" supported by the sentence: ""OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.""?",False, -18846793,Sodium Fluoride affects allergic disease,701,"At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).","Is the triple ""Sodium Fluoride affects allergic disease"" supported by the sentence: ""At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).""?",False, -25986070,Sodium Fluoride disrupts allergic disease,702,"In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.","Is the triple ""Sodium Fluoride disrupts allergic disease"" supported by the sentence: ""In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.""?",False, -14286543,Sodium Fluoride prevents gingivitis,703,"Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.","Is the triple ""Sodium Fluoride prevents gingivitis"" supported by the sentence: ""Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.""?",False, -10538561,Sodium Fluoride prevents periodontal disorder,704,Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.,"Is the triple ""Sodium Fluoride prevents periodontal disorder"" supported by the sentence: ""Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.""?",False, -10425615,Sodium Fluoride prevents dental caries,705,Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.,"Is the triple ""Sodium Fluoride prevents dental caries"" supported by the sentence: ""Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.""?",False, -19971424,Rifaximin related to irritable bowel syndrome,706,"In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.","Is the triple ""Rifaximin related to irritable bowel syndrome"" supported by the sentence: ""In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.""?",False, -17053293,Rifaximin related to hepatic encephalopathy,707,Rifaximin and lactulose have shown to be effective in HE.,"Is the triple ""Rifaximin related to hepatic encephalopathy"" supported by the sentence: ""Rifaximin and lactulose have shown to be effective in HE.""?",False, -18714048,Rifaximin causes irritable bowel syndrome,708,"Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.","Is the triple ""Rifaximin causes irritable bowel syndrome"" supported by the sentence: ""Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.""?",False, -8925773,Rifaximin causes diarrheal disease,709,"In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.","Is the triple ""Rifaximin causes diarrheal disease"" supported by the sentence: ""In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.""?",False, -25434952,Rifaximin affects alcoholic hepatitis,710,"Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.","Is the triple ""Rifaximin affects alcoholic hepatitis"" supported by the sentence: ""Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.""?",False, -24257624,Rifaximin affects Infection,711,"Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).","Is the triple ""Rifaximin affects Infection"" supported by the sentence: ""Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).""?",False, -20149851,Rifaximin affects Crohn disease,712,"In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.","Is the triple ""Rifaximin affects Crohn disease"" supported by the sentence: ""In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.""?",False, -19665399,Rifaximin affects diverticulitis,713,The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.,"Is the triple ""Rifaximin affects diverticulitis"" supported by the sentence: ""The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.""?",False, -18685028,Rifaximin affects irritable bowel syndrome,714,AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.,"Is the triple ""Rifaximin affects irritable bowel syndrome"" supported by the sentence: ""AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.""?",False, -16575444,Rifaximin affects hepatic encephalopathy,715,Rifaximin may have a dramatic effect on hepatic encephalopathy.,"Is the triple ""Rifaximin affects hepatic encephalopathy"" supported by the sentence: ""Rifaximin may have a dramatic effect on hepatic encephalopathy.""?",False, -21278571,Rifaximin prevents alcoholic hepatitis,716,"In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.","Is the triple ""Rifaximin prevents alcoholic hepatitis"" supported by the sentence: ""In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.""?",False, -16143515,Rifaximin prevents diverticulitis,717,No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.,"Is the triple ""Rifaximin prevents diverticulitis"" supported by the sentence: ""No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.""?",False, -15134586,Rifaximin prevents hepatic encephalopathy,718,Gut instinct: rifaximin for the prevention of hepatic encephalopathy.,"Is the triple ""Rifaximin prevents hepatic encephalopathy"" supported by the sentence: ""Gut instinct: rifaximin for the prevention of hepatic encephalopathy.""?",False, -11830138,Rifaximin prevents irritable bowel syndrome,719,Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.,"Is the triple ""Rifaximin prevents irritable bowel syndrome"" supported by the sentence: ""Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.""?",False, -11830137,Rifaximin prevents diarrheal disease,720,A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.,"Is the triple ""Rifaximin prevents diarrheal disease"" supported by the sentence: ""A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.""?",False, -15717459,Rifaximin predisposes hepatic encephalopathy,721,This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.,"Is the triple ""Rifaximin predisposes hepatic encephalopathy"" supported by the sentence: ""This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.""?",False, -25706307,Glycine related to cystic fibrosis,722,Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.,"Is the triple ""Glycine related to cystic fibrosis"" supported by the sentence: ""Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.""?",False, -20102524,Glycine related to psychotic disorder,723,"Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.","Is the triple ""Glycine related to psychotic disorder"" supported by the sentence: ""Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.""?",False, -17514096,Glycine related to hypertensive disorder,724,CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.,"Is the triple ""Glycine related to hypertensive disorder"" supported by the sentence: ""CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.""?",False, -13080824,Glycine related to Alzheimer disease,725,We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.,"Is the triple ""Glycine related to Alzheimer disease"" supported by the sentence: ""We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.""?",False, -12589996,Glycine related to nutritional disorder,726,Glycine production in severe childhood undernutrition.,"Is the triple ""Glycine related to nutritional disorder"" supported by the sentence: ""Glycine production in severe childhood undernutrition.""?",False, -7298031,Glycine related to schizophrenia,727,"Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.","Is the triple ""Glycine related to schizophrenia"" supported by the sentence: ""Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.""?",False, -17397486,Glycine causes Cognitive impairment,728,"The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.","Is the triple ""Glycine causes Cognitive impairment"" supported by the sentence: ""The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.""?",False, -17125423,Glycine affects asthma,729,"However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).","Is the triple ""Glycine affects asthma"" supported by the sentence: ""However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).""?",False, -7530162,Glycine affects schizophrenia,730,"To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.","Is the triple ""Glycine affects schizophrenia"" supported by the sentence: ""To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.""?",False, -12589998,Glycine produces nutritional disorder,731,OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.,"Is the triple ""Glycine produces nutritional disorder"" supported by the sentence: ""OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.""?",False, -16845009,Glycine disrupts Alzheimer disease,732,"[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.","Is the triple ""Glycine disrupts Alzheimer disease"" supported by the sentence: ""[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.""?",False, -12278394,Glycine prevents hypertensive disorder,733,"The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.","Is the triple ""Glycine prevents hypertensive disorder"" supported by the sentence: ""The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.""?",False, -15546112,Glycine predisposes asthma,734,"Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.","Is the triple ""Glycine predisposes asthma"" supported by the sentence: ""Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.""?",False, -16711324,Sorbitol related to injury,735,"CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.","Is the triple ""Sorbitol related to injury"" supported by the sentence: ""CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.""?",False, -10684679,Sorbitol related to constipation disorder,736,[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].,"Is the triple ""Sorbitol related to constipation disorder"" supported by the sentence: ""[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].""?",False, -20821510,Sorbitol causes constipation disorder,737,"However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.","Is the triple ""Sorbitol causes constipation disorder"" supported by the sentence: ""However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.""?",False, -15564538,Sorbitol causes injury,738,"Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.","Is the triple ""Sorbitol causes injury"" supported by the sentence: ""Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.""?",False, -17658899,Sorbitol affects osteoarthritis,739,"CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.","Is the triple ""Sorbitol affects osteoarthritis"" supported by the sentence: ""CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.""?",False, -26106951,Sorbitol prevents injury,740,"Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.","Is the triple ""Sorbitol prevents injury"" supported by the sentence: ""Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.""?",False, -10478248,Foscarnet affects cytomegalovirus infection,741,We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.,"Is the triple ""Foscarnet affects cytomegalovirus infection"" supported by the sentence: ""We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.""?",False, -10481132,Foscarnet prevents cytomegalovirus infection,742,The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.,"Is the triple ""Foscarnet prevents cytomegalovirus infection"" supported by the sentence: ""The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.""?",False, -22857734,Atogepant prevents migraine disorder,743,"Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.","Is the triple ""Atogepant prevents migraine disorder"" supported by the sentence: ""Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.""?",False, -25325960,Rimegepant prevents migraine disorder,744,"As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.","Is the triple ""Rimegepant prevents migraine disorder"" supported by the sentence: ""As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.""?",False, -21939131,Rimegepant prevents Pain,745,"The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.","Is the triple ""Rimegepant prevents Pain"" supported by the sentence: ""The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.""?",False, -10553741,ATROPINE related to poisoning,746,"[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].","Is the triple ""ATROPINE related to poisoning"" supported by the sentence: ""[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].""?",False, -19468294,ATROPINE causes Pain,747,"In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.","Is the triple ""ATROPINE causes Pain"" supported by the sentence: ""In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.""?",False, -18989245,ATROPINE causes digestive system disorder,748,"With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.","Is the triple ""ATROPINE causes digestive system disorder"" supported by the sentence: ""With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.""?",False, -14576640,ATROPINE causes myopia,749,"PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.","Is the triple ""ATROPINE causes myopia"" supported by the sentence: ""PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.""?",False, -10716177,ATROPINE causes Mydriasis,750,"The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.","Is the triple ""ATROPINE causes Mydriasis"" supported by the sentence: ""The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.""?",False, -10361041,ATROPINE causes amblyopia,751,"OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.","Is the triple ""ATROPINE causes amblyopia"" supported by the sentence: ""OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.""?",False, -9746341,ATROPINE causes poisoning,752,"Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.","Is the triple ""ATROPINE causes poisoning"" supported by the sentence: ""Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.""?",False, -9301311,ATROPINE causes cardiac arrest,753,"Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.","Is the triple ""ATROPINE causes cardiac arrest"" supported by the sentence: ""Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.""?",False, -8524259,ATROPINE causes Insulin resistance,754,Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.,"Is the triple ""ATROPINE causes Insulin resistance"" supported by the sentence: ""Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.""?",False, -8480152,ATROPINE causes Bradycardia,755,In 6-week-old rats atropine produced bradycardia instead of tachycardia.,"Is the triple ""ATROPINE causes Bradycardia"" supported by the sentence: ""In 6-week-old rats atropine produced bradycardia instead of tachycardia.""?",False, -26343406,ATROPINE affects hypoglycemia,756,"3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.""?",False, -23118209,ATROPINE affects Mydriasis,757,Both im and iv atropine had similar effects on weight loss rate and mydriasis.,"Is the triple ""ATROPINE affects Mydriasis"" supported by the sentence: ""Both im and iv atropine had similar effects on weight loss rate and mydriasis.""?",False, -19520979,ATROPINE affects hypoglycemia,758,"The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.""?",False, -12406813,ATROPINE affects cardiac arrest,759,Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.,"Is the triple ""ATROPINE affects cardiac arrest"" supported by the sentence: ""Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.""?",False, -11741867,ATROPINE affects Bradycardia,760,"LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.""?",False, -10264479,ATROPINE affects Hemorrhage,761,"Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.","Is the triple ""ATROPINE affects Hemorrhage"" supported by the sentence: ""Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.""?",False, -9293832,ATROPINE affects poisoning,762,"Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.","Is the triple ""ATROPINE affects poisoning"" supported by the sentence: ""Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.""?",False, -9041302,ATROPINE affects Bradycardia,763,"This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.""?",False, -7845760,ATROPINE affects Bradycardia,764,"CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.""?",False, -7111083,ATROPINE affects myopia,765,"These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.","Is the triple ""ATROPINE affects myopia"" supported by the sentence: ""These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.""?",False, -26141463,ATROPINE disrupts hypoglycemia,766,The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.,"Is the triple ""ATROPINE disrupts hypoglycemia"" supported by the sentence: ""The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.""?",False, -23143978,ATROPINE disrupts poisoning,767,"Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.","Is the triple ""ATROPINE disrupts poisoning"" supported by the sentence: ""Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.""?",False, -20133204,ATROPINE disrupts Pain,768,Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?,"Is the triple ""ATROPINE disrupts Pain"" supported by the sentence: ""Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?""?",False, -18168420,ATROPINE disrupts Bradycardia,769,"After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.","Is the triple ""ATROPINE disrupts Bradycardia"" supported by the sentence: ""After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.""?",False, -7111084,ATROPINE disrupts myopia,770,"Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.","Is the triple ""ATROPINE disrupts myopia"" supported by the sentence: ""Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.""?",False, -9676858,ATROPINE prevents poisoning,771,Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.,"Is the triple ""ATROPINE prevents poisoning"" supported by the sentence: ""Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.""?",False, -9198373,ATROPINE prevents myopia,772,"One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.","Is the triple ""ATROPINE prevents myopia"" supported by the sentence: ""One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.""?",False, -8451883,ATROPINE prevents cardiac arrest,773,Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.,"Is the triple ""ATROPINE prevents cardiac arrest"" supported by the sentence: ""Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.""?",False, -23699298,ATROPINE predisposes myopia,774,"Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).","Is the triple ""ATROPINE predisposes myopia"" supported by the sentence: ""Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).""?",False, -14640163,ATROPINE predisposes poisoning,775,"A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.","Is the triple ""ATROPINE predisposes poisoning"" supported by the sentence: ""A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.""?",False, -7953996,Tolcapone affects Parkinson disease,776,"Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.","Is the triple ""Tolcapone affects Parkinson disease"" supported by the sentence: ""Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.""?",False, -15643297,Entacapone related to Parkinson disease,777,OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.,"Is the triple ""Entacapone related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.""?",False, -10033650,Entacapone causes Parkinson disease,778,"Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.","Is the triple ""Entacapone causes Parkinson disease"" supported by the sentence: ""Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.""?",False, -15952178,Entacapone affects Parkinson disease,779,Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.,"Is the triple ""Entacapone affects Parkinson disease"" supported by the sentence: ""Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.""?",False, -20308336,Entacapone disrupts Parkinson disease,780,"Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).","Is the triple ""Entacapone disrupts Parkinson disease"" supported by the sentence: ""Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).""?",False, -25394620,Veliparib affects neoplasm,781,"[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).","Is the triple ""Veliparib affects neoplasm"" supported by the sentence: ""[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).""?",False, -21697473,Veliparib affects triple-negative breast carcinoma,782,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Veliparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, -21882624,Talazoparib causes neoplasm,783,"In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.","Is the triple ""Talazoparib causes neoplasm"" supported by the sentence: ""In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.""?",False, -22572154,Talazoparib affects neoplasm,784,The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.,"Is the triple ""Talazoparib affects neoplasm"" supported by the sentence: ""The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.""?",False, -21697476,Talazoparib affects triple-negative breast carcinoma,785,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Talazoparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, -22916819,Talazoparib prevents neoplasm,786,Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.,"Is the triple ""Talazoparib prevents neoplasm"" supported by the sentence: ""Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.""?",False, -24451977,Olaparib related to triple-negative breast carcinoma,787,"Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.","Is the triple ""Olaparib related to triple-negative breast carcinoma"" supported by the sentence: ""Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.""?",False, -25473017,Olaparib causes pancreatic ductal adenocarcinoma,788,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes pancreatic ductal adenocarcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, -25473016,Olaparib causes non-small cell lung carcinoma,789,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes non-small cell lung carcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, -22160122,Olaparib causes head and neck neoplasm,790,"Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.","Is the triple ""Olaparib causes head and neck neoplasm"" supported by the sentence: ""Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.""?",False, -24770500,Olaparib affects castration-resistant prostate carcinoma,791,Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.,"Is the triple ""Olaparib affects castration-resistant prostate carcinoma"" supported by the sentence: ""Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.""?",False, -24672020,Olaparib affects prostate cancer,792,"Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.","Is the triple ""Olaparib affects prostate cancer"" supported by the sentence: ""Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.""?",False, -22977330,Olaparib affects neoplasm,793,TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.,"Is the triple ""Olaparib affects neoplasm"" supported by the sentence: ""TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.""?",False, -21697474,Olaparib affects triple-negative breast carcinoma,794,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Olaparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, -24201965,Olaparib prevents Neoplasm Metastasis,795,The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.,"Is the triple ""Olaparib prevents Neoplasm Metastasis"" supported by the sentence: ""The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.""?",False, -27698235,Capsaicin related to arthritic joint disease,796,"Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.","Is the triple ""Capsaicin related to arthritic joint disease"" supported by the sentence: ""Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.""?",False, -22276323,Capsaicin related to herpes zoster,797,Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.,"Is the triple ""Capsaicin related to herpes zoster"" supported by the sentence: ""Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.""?",False, -13200623,Capsaicin related to migraine disorder,798,Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.,"Is the triple ""Capsaicin related to migraine disorder"" supported by the sentence: ""Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.""?",False, -11537529,Capsaicin related to Cough,799,"Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.","Is the triple ""Capsaicin related to Cough"" supported by the sentence: ""Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.""?",False, -10028696,Capsaicin related to diabetic neuropathy,800,"CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.","Is the triple ""Capsaicin related to diabetic neuropathy"" supported by the sentence: ""CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.""?",False, -8608120,Capsaicin related to osteoarthritis,801,The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.,"Is the triple ""Capsaicin related to osteoarthritis"" supported by the sentence: ""The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.""?",False, -8470968,Capsaicin related to postherpetic neuralgia,802,"These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.","Is the triple ""Capsaicin related to postherpetic neuralgia"" supported by the sentence: ""These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.""?",False, -8246278,Capsaicin related to neuralgia,803,3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.,"Is the triple ""Capsaicin related to neuralgia"" supported by the sentence: ""3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.""?",False, -7965643,Capsaicin related to Pruritus,804,"As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).","Is the triple ""Capsaicin related to Pruritus"" supported by the sentence: ""As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).""?",False, -7239245,Capsaicin related to Pain,805,Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.,"Is the triple ""Capsaicin related to Pain"" supported by the sentence: ""Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.""?",False, -26554289,Capsaicin causes stroke disorder,806,MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.,"Is the triple ""Capsaicin causes stroke disorder"" supported by the sentence: ""MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.""?",False, -24505933,Capsaicin causes Muscle spasm,807,"The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.","Is the triple ""Capsaicin causes Muscle spasm"" supported by the sentence: ""The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.""?",False, -18391785,Capsaicin causes neuralgia,808,Can topical capsaicin induce a neuropathic pain?,"Is the triple ""Capsaicin causes neuralgia"" supported by the sentence: ""Can topical capsaicin induce a neuropathic pain?""?",False, -16420383,Capsaicin causes migraine disorder,809,CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.,"Is the triple ""Capsaicin causes migraine disorder"" supported by the sentence: ""CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.""?",False, -11163813,Capsaicin causes arthritic joint disease,810,Capsaicin-induced joint inflammation is not blocked by local anesthesia.,"Is the triple ""Capsaicin causes arthritic joint disease"" supported by the sentence: ""Capsaicin-induced joint inflammation is not blocked by local anesthesia.""?",False, -9650510,Capsaicin causes Myalgia,811,Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.,"Is the triple ""Capsaicin causes Myalgia"" supported by the sentence: ""Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.""?",False, -8975038,Capsaicin causes Vomiting,812,"E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).","Is the triple ""Capsaicin causes Vomiting"" supported by the sentence: ""E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).""?",False, -8261437,Capsaicin causes Cough,813,The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.,"Is the triple ""Capsaicin causes Cough"" supported by the sentence: ""The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.""?",False, -7430731,Capsaicin causes Pruritus,814,"Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.","Is the triple ""Capsaicin causes Pruritus"" supported by the sentence: ""Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.""?",False, -7414435,Capsaicin causes Pain,815,Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.,"Is the triple ""Capsaicin causes Pain"" supported by the sentence: ""Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.""?",False, -27524804,Capsaicin affects arthritic joint disease,816,Effects of capsaicin in temporomandibular joint arthritis in rats.,"Is the triple ""Capsaicin affects arthritic joint disease"" supported by the sentence: ""Effects of capsaicin in temporomandibular joint arthritis in rats.""?",False, -25438971,Capsaicin affects brain injury,817,"Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.","Is the triple ""Capsaicin affects brain injury"" supported by the sentence: ""Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.""?",False, -19404541,Capsaicin affects neuroma,818,"There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.","Is the triple ""Capsaicin affects neuroma"" supported by the sentence: ""There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.""?",False, -15791019,Capsaicin affects Pruritus,819,"A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).""?",False, -10951234,Capsaicin affects stroke disorder,820,"Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.","Is the triple ""Capsaicin affects stroke disorder"" supported by the sentence: ""Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.""?",False, -10764355,Capsaicin affects Pain,821,"Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.""?",False, -10290167,Capsaicin affects Pruritus,822,"As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.""?",False, -10171204,Capsaicin affects neuralgia,823,"Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.","Is the triple ""Capsaicin affects neuralgia"" supported by the sentence: ""Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.""?",False, -8975035,Capsaicin affects Vomiting,824,The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.,"Is the triple ""Capsaicin affects Vomiting"" supported by the sentence: ""The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.""?",False, -8515286,Capsaicin affects Pain,825,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, -8515285,Capsaicin affects postherpetic neuralgia,826,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects postherpetic neuralgia"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, -8441743,Capsaicin affects Cough,827,Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.""?",False, -7281158,Capsaicin affects Cough,828,Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.""?",False, -18283970,Capsaicin disrupts Pain,829,"Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.","Is the triple ""Capsaicin disrupts Pain"" supported by the sentence: ""Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.""?",False, -17652809,Capsaicin disrupts arthritic joint disease,830,Capsaicin suppresses substance P-induced joint inflammation in the rat.,"Is the triple ""Capsaicin disrupts arthritic joint disease"" supported by the sentence: ""Capsaicin suppresses substance P-induced joint inflammation in the rat.""?",False, -14643733,Capsaicin disrupts breast neoplasm,831,"Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.","Is the triple ""Capsaicin disrupts breast neoplasm"" supported by the sentence: ""Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.""?",False, -9869751,Capsaicin disrupts Cough,832,"To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.","Is the triple ""Capsaicin disrupts Cough"" supported by the sentence: ""To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.""?",False, -8160008,Capsaicin disrupts Pruritus,833,RESULTS: Capsaicin suppressed completely itch in all patients.,"Is the triple ""Capsaicin disrupts Pruritus"" supported by the sentence: ""RESULTS: Capsaicin suppressed completely itch in all patients.""?",False, -25438980,Capsaicin prevents brain injury,834,Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.,"Is the triple ""Capsaicin prevents brain injury"" supported by the sentence: ""Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.""?",False, -20404597,Capsaicin prevents postherpetic neuralgia,835,The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.,"Is the triple ""Capsaicin prevents postherpetic neuralgia"" supported by the sentence: ""The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.""?",False, -17168513,Capsaicin prevents migraine disorder,836,"Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.","Is the triple ""Capsaicin prevents migraine disorder"" supported by the sentence: ""Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.""?",False, -16978917,Capsaicin prevents neuralgia,837,Capsaicin treatment is one method to reduce neuropathic pain.,"Is the triple ""Capsaicin prevents neuralgia"" supported by the sentence: ""Capsaicin treatment is one method to reduce neuropathic pain.""?",False, -15822967,Capsaicin prevents stroke disorder,838,We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).,"Is the triple ""Capsaicin prevents stroke disorder"" supported by the sentence: ""We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).""?",False, -10290168,Capsaicin prevents Pruritus,839,"In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.","Is the triple ""Capsaicin prevents Pruritus"" supported by the sentence: ""In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.""?",False, -8608117,Capsaicin prevents osteoarthritis,840,The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.,"Is the triple ""Capsaicin prevents osteoarthritis"" supported by the sentence: ""The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.""?",False, -8246280,Capsaicin prevents Pain,841,"RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.","Is the triple ""Capsaicin prevents Pain"" supported by the sentence: ""RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.""?",False, -14706687,Capsaicin predisposes Pain,842,These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.,"Is the triple ""Capsaicin predisposes Pain"" supported by the sentence: ""These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.""?",False, -24021484,Nusinersen causes spinal muscular atrophy,843,"Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.","Is the triple ""Nusinersen causes spinal muscular atrophy"" supported by the sentence: ""Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.""?",False, -22907909,Nusinersen affects spinal muscular atrophy,844,More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.,"Is the triple ""Nusinersen affects spinal muscular atrophy"" supported by the sentence: ""More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.""?",False, -27681284,Hyaluronic acid sodium salt related to alcoholic hepatitis,845,"These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.","Is the triple ""Hyaluronic acid sodium salt related to alcoholic hepatitis"" supported by the sentence: ""These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.""?",False, -26794689,Hyaluronic acid sodium salt related to carpal tunnel syndrome,846,"In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.","Is the triple ""Hyaluronic acid sodium salt related to carpal tunnel syndrome"" supported by the sentence: ""In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.""?",False, -20903427,Hyaluronic acid sodium salt related to Skin ulcer,847,Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.,"Is the triple ""Hyaluronic acid sodium salt related to Skin ulcer"" supported by the sentence: ""Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.""?",False, -18915649,Hyaluronic acid sodium salt related to Hyaluronidase,848,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, -18915649,Hyaluronic acid sodium salt related to Hyaluronidase,849,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, -15362486,Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder,850,OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.,"Is the triple ""Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder"" supported by the sentence: ""OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.""?",False, -14268478,Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease,851,Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.,"Is the triple ""Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease"" supported by the sentence: ""Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.""?",False, -9147590,Hyaluronic acid sodium salt related to dry eye syndrome,852,Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.,"Is the triple ""Hyaluronic acid sodium salt related to dry eye syndrome"" supported by the sentence: ""Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.""?",False, -7458117,Hyaluronic acid sodium salt related to osteoarthritis,853,OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.,"Is the triple ""Hyaluronic acid sodium salt related to osteoarthritis"" supported by the sentence: ""OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.""?",False, -17074499,Hyaluronic acid sodium salt related to Hyaluronidase,854,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, -17074499,Hyaluronic acid sodium salt related to Hyaluronidase,855,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, -12401778,Hyaluronic acid sodium salt has part Hyaluronidase,856,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, -12401778,Hyaluronic acid sodium salt has part Hyaluronidase,857,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, -11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,858,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, -11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,859,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, -7287149,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,860,The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.""?",False, -7699622,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,861,Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.""?",False, -12146167,Hyaluronic acid sodium salt causes osteoarthritis,862,We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).,"Is the triple ""Hyaluronic acid sodium salt causes osteoarthritis"" supported by the sentence: ""We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).""?",False, -8938037,Hyaluronic acid sodium salt affects osteoarthritis,863,"RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.","Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.""?",False, -8541022,Hyaluronic acid sodium salt affects osteoarthritis,864,The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.,"Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.""?",False, -7683831,Hyaluronic acid sodium salt affects Hyaluronidase,865,Such small HA fragments are generated from the degradation of HA by hyaluronidase.,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""Such small HA fragments are generated from the degradation of HA by hyaluronidase.""?",False, -7895314,Hyaluronic acid sodium salt affects Hyaluronidase,866,RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).""?",False, -18839068,Hyaluronic acid sodium salt produces Hyaluronidase,867,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, -18839068,Hyaluronic acid sodium salt produces Hyaluronidase,868,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, -9813251,Hyaluronic acid sodium salt produces Hyaluronidase,869,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, -9813251,Hyaluronic acid sodium salt produces Hyaluronidase,870,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, -17165364,Hyaluronic acid sodium salt has input Hyaluronidase,871,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, -17165364,Hyaluronic acid sodium salt has input Hyaluronidase,872,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, -23839601,Hyaluronic acid sodium salt disrupts dry eye syndrome,873,Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.,"Is the triple ""Hyaluronic acid sodium salt disrupts dry eye syndrome"" supported by the sentence: ""Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.""?",False, -22764727,Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder,874,"Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.","Is the triple ""Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder"" supported by the sentence: ""Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.""?",False, -7155073,Hyaluronic acid sodium salt disrupts osteoarthritis,875,"Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.","Is the triple ""Hyaluronic acid sodium salt disrupts osteoarthritis"" supported by the sentence: ""Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.""?",False, -18262848,Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease,876,Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.,"Is the triple ""Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.""?",False, -11511344,Hyaluronic acid sodium salt prevents osteoarthritis,877,The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.,"Is the triple ""Hyaluronic acid sodium salt prevents osteoarthritis"" supported by the sentence: ""The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.""?",False, -21264578,Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder,878,"CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.","Is the triple ""Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder"" supported by the sentence: ""CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.""?",False, -11605823,Hyaluronic acid sodium salt predisposes osteoarthritis,879,CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.,"Is the triple ""Hyaluronic acid sodium salt predisposes osteoarthritis"" supported by the sentence: ""CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.""?",False, -24659748,Zoledronic acid related to osteoporosis,880,"Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.","Is the triple ""Zoledronic acid related to osteoporosis"" supported by the sentence: ""Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.""?",False, -18902207,Zoledronic acid causes Marchiafava-Bignami disease,881,Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.,"Is the triple ""Zoledronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.""?",False, -18856931,Zoledronic acid causes hepatocellular carcinoma,882,"This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.","Is the triple ""Zoledronic acid causes hepatocellular carcinoma"" supported by the sentence: ""This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.""?",False, -13083414,Zoledronic acid causes bone fracture,883,"The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.","Is the triple ""Zoledronic acid causes bone fracture"" supported by the sentence: ""The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.""?",False, -21044659,Zoledronic acid affects Marchiafava-Bignami disease,884,Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.,"Is the triple ""Zoledronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.""?",False, -19059032,Zoledronic acid affects bone osteosarcoma,885,"BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.","Is the triple ""Zoledronic acid affects bone osteosarcoma"" supported by the sentence: ""BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.""?",False, -13892047,Zoledronic acid affects bone fracture,886,Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.,"Is the triple ""Zoledronic acid affects bone fracture"" supported by the sentence: ""Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.""?",False, -13448998,Zoledronic acid affects osteonecrosis,887,"Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.","Is the triple ""Zoledronic acid affects osteonecrosis"" supported by the sentence: ""Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.""?",False, -9617769,Zoledronic acid affects osteoporosis,888,Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.,"Is the triple ""Zoledronic acid affects osteoporosis"" supported by the sentence: ""Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.""?",False, -24472422,Zoledronic acid disrupts sarcoma,889,Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.,"Is the triple ""Zoledronic acid disrupts sarcoma"" supported by the sentence: ""Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.""?",False, -20879055,Zoledronic acid disrupts Neoplasm Metastasis,890,"Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.","Is the triple ""Zoledronic acid disrupts Neoplasm Metastasis"" supported by the sentence: ""Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.""?",False, -20879053,Zoledronic acid disrupts Pain,891,Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.,"Is the triple ""Zoledronic acid disrupts Pain"" supported by the sentence: ""Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.""?",False, -13311906,Zoledronic acid disrupts hepatocellular carcinoma,892,"Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.","Is the triple ""Zoledronic acid disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.""?",False, -9617771,Zoledronic acid disrupts bone fracture,893,"If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.","Is the triple ""Zoledronic acid disrupts bone fracture"" supported by the sentence: ""If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.""?",False, -22662537,Zoledronic acid prevents osteoporosis,894,"As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.","Is the triple ""Zoledronic acid prevents osteoporosis"" supported by the sentence: ""As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.""?",False, -20148397,Zoledronic acid prevents osteonecrosis,895,Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.,"Is the triple ""Zoledronic acid prevents osteonecrosis"" supported by the sentence: ""Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.""?",False, -13621414,Zoledronic acid prevents bone fracture,896,"5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.","Is the triple ""Zoledronic acid prevents bone fracture"" supported by the sentence: ""5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.""?",False, -12127006,Zoledronic acid prevents Marchiafava-Bignami disease,897,CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.,"Is the triple ""Zoledronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.""?",False, -20851623,Zoledronic acid predisposes bone fracture,898,"A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.","Is the triple ""Zoledronic acid predisposes bone fracture"" supported by the sentence: ""A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.""?",False, -15272127,Zoledronic acid predisposes osteonecrosis,899,"Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.","Is the triple ""Zoledronic acid predisposes osteonecrosis"" supported by the sentence: ""Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.""?",False, -14006582,Risedronic acid prevents osteoporosis,900,"A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.","Is the triple ""Risedronic acid prevents osteoporosis"" supported by the sentence: ""A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.""?",False, -17290459,IBANDRONIC ACID affects osteonecrosis,901,"Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.","Is the triple ""IBANDRONIC ACID affects osteonecrosis"" supported by the sentence: ""Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.""?",False, -9797983,IBANDRONIC ACID affects Neoplasm Metastasis,902,Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.,"Is the triple ""IBANDRONIC ACID affects Neoplasm Metastasis"" supported by the sentence: ""Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.""?",False, -15290649,IBANDRONIC ACID prevents bone disorder,903,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""IBANDRONIC ACID prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, -13697992,IBANDRONIC ACID prevents Pain,904,"Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.","Is the triple ""IBANDRONIC ACID prevents Pain"" supported by the sentence: ""Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.""?",False, -10307139,IBANDRONIC ACID prevents postmenopausal osteoporosis,905,"OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.","Is the triple ""IBANDRONIC ACID prevents postmenopausal osteoporosis"" supported by the sentence: ""OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.""?",False, -10028971,IBANDRONIC ACID prevents osteoporosis,906,These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.,"Is the triple ""IBANDRONIC ACID prevents osteoporosis"" supported by the sentence: ""These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.""?",False, -18363632,IBANDRONIC ACID predisposes Abdominal pain,907,"The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.","Is the triple ""IBANDRONIC ACID predisposes Abdominal pain"" supported by the sentence: ""The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.""?",False, -9434475,IBANDRONIC ACID predisposes osteoporosis,908,The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.,"Is the triple ""IBANDRONIC ACID predisposes osteoporosis"" supported by the sentence: ""The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.""?",False, -17514758,Alendronic acid related to osteoarthritis,909,OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.,"Is the triple ""Alendronic acid related to osteoarthritis"" supported by the sentence: ""OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.""?",False, -14283477,Alendronic acid related to osteoporosis,910,"To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.","Is the triple ""Alendronic acid related to osteoporosis"" supported by the sentence: ""To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.""?",False, -11575454,Alendronic acid related to postmenopausal osteoporosis,911,Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.,"Is the triple ""Alendronic acid related to postmenopausal osteoporosis"" supported by the sentence: ""Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.""?",False, -14254304,Alendronic acid causes asthma,912,Alendronate-induced asthma.,"Is the triple ""Alendronic acid causes asthma"" supported by the sentence: ""Alendronate-induced asthma.""?",False, -14049757,Alendronic acid causes osteoporosis,913,The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.,"Is the triple ""Alendronic acid causes osteoporosis"" supported by the sentence: ""The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.""?",False, -11710947,Alendronic acid causes Marchiafava-Bignami disease,914,Alendronate as an effective countermeasure to disuse induced bone loss.,"Is the triple ""Alendronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate as an effective countermeasure to disuse induced bone loss.""?",False, -25124892,Alendronic acid affects Marchiafava-Bignami disease,915,"EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.","Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.""?",False, -24296937,Alendronic acid affects bone disorder,916,The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.,"Is the triple ""Alendronic acid affects bone disorder"" supported by the sentence: ""The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.""?",False, -17701514,Alendronic acid affects osteoarthritis,917,This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.,"Is the triple ""Alendronic acid affects osteoarthritis"" supported by the sentence: ""This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.""?",False, -14769549,Alendronic acid affects postmenopausal osteoporosis,918,The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.,"Is the triple ""Alendronic acid affects postmenopausal osteoporosis"" supported by the sentence: ""The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.""?",False, -12316243,Alendronic acid affects osteoporosis,919,"Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.","Is the triple ""Alendronic acid affects osteoporosis"" supported by the sentence: ""Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.""?",False, -12136907,Alendronic acid affects periodontitis,920,We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.,"Is the triple ""Alendronic acid affects periodontitis"" supported by the sentence: ""We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.""?",False, -8809813,Alendronic acid affects Marchiafava-Bignami disease,921,We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.,"Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.""?",False, -22627610,Alendronic acid disrupts aortic valve stenosis,922,Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.,"Is the triple ""Alendronic acid disrupts aortic valve stenosis"" supported by the sentence: ""Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.""?",False, -17047070,Alendronic acid disrupts prostate cancer,923,"For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).","Is the triple ""Alendronic acid disrupts prostate cancer"" supported by the sentence: ""For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).""?",False, -9109277,Alendronic acid disrupts Marchiafava-Bignami disease,924,"Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.","Is the triple ""Alendronic acid disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.""?",False, -8466156,Alendronic acid disrupts postmenopausal osteoporosis,925,(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.,"Is the triple ""Alendronic acid disrupts postmenopausal osteoporosis"" supported by the sentence: ""(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.""?",False, -24628288,Alendronic acid prevents osteoarthritis,926,"Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.","Is the triple ""Alendronic acid prevents osteoarthritis"" supported by the sentence: ""Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.""?",False, -15290647,Alendronic acid prevents bone disorder,927,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""Alendronic acid prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, -7495571,Alendronic acid prevents osteoporosis,928,"Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.","Is the triple ""Alendronic acid prevents osteoporosis"" supported by the sentence: ""Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.""?",False, -7314446,Alendronic acid prevents Marchiafava-Bignami disease,929,Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.,"Is the triple ""Alendronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.""?",False, -7150371,Alendronic acid prevents postmenopausal osteoporosis,930,Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).,"Is the triple ""Alendronic acid prevents postmenopausal osteoporosis"" supported by the sentence: ""Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).""?",False, -25381093,Alendronic acid predisposes osteoporosis,931,"In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.","Is the triple ""Alendronic acid predisposes osteoporosis"" supported by the sentence: ""In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.""?",False, -22975353,Alendronic acid predisposes Marchiafava-Bignami disease,932,We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.,"Is the triple ""Alendronic acid predisposes Marchiafava-Bignami disease"" supported by the sentence: ""We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.""?",False, -12652815,Pamidronic acid related to osteoporosis,933,The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.,"Is the triple ""Pamidronic acid related to osteoporosis"" supported by the sentence: ""The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.""?",False, -7541169,Pamidronic acid related to plasma cell myeloma,934,Effect of calcitriol and pamidronate in multiple myeloma.,"Is the triple ""Pamidronic acid related to plasma cell myeloma"" supported by the sentence: ""Effect of calcitriol and pamidronate in multiple myeloma.""?",False, -12040766,Pamidronic acid affects plasma cell myeloma,935,"MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.","Is the triple ""Pamidronic acid affects plasma cell myeloma"" supported by the sentence: ""MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.""?",False, -10860757,Pamidronic acid affects osteoporosis,936,The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.,"Is the triple ""Pamidronic acid affects osteoporosis"" supported by the sentence: ""The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.""?",False, -9170219,Pamidronic acid prevents osteoporosis,937,Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.,"Is the triple ""Pamidronic acid prevents osteoporosis"" supported by the sentence: ""Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.""?",False, -9315699,Octyl methoxycinnamate prevents sunburn,938,"In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.","Is the triple ""Octyl methoxycinnamate prevents sunburn"" supported by the sentence: ""In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.""?",False, -10529058,4-Aminobenzoic acid coexists with Procaine,939,[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].,"Is the triple ""4-Aminobenzoic acid coexists with Procaine"" supported by the sentence: ""[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].""?",False, -25771688,Nitrazepam causes epilepsy,940,The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.,"Is the triple ""Nitrazepam causes epilepsy"" supported by the sentence: ""The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.""?",False, -19206956,Nitrazepam affects depressive disorder,941,The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.,"Is the triple ""Nitrazepam affects depressive disorder"" supported by the sentence: ""The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.""?",False, -25737609,Nitrazepam disrupts epilepsy,942,"Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.","Is the triple ""Nitrazepam disrupts epilepsy"" supported by the sentence: ""Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.""?",False, -7322742,Nitrazepam prevents epilepsy,943,NZP was discontinued if there was < 50% seizure reduction or significant side effects.,"Is the triple ""Nitrazepam prevents epilepsy"" supported by the sentence: ""NZP was discontinued if there was < 50% seizure reduction or significant side effects.""?",False, -25779340,Flurazepam causes depressive disorder,944,"Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.","Is the triple ""Flurazepam causes depressive disorder"" supported by the sentence: ""Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.""?",False, -19092155,Triazolam causes depressive disorder,945,"In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.","Is the triple ""Triazolam causes depressive disorder"" supported by the sentence: ""In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.""?",False, -16852864,Triazolam causes insomnia,946,"This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.","Is the triple ""Triazolam causes insomnia"" supported by the sentence: ""This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.""?",False, -27224077,Triazolam affects insomnia,947,OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).,"Is the triple ""Triazolam affects insomnia"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).""?",False, -15159227,Triazolam disrupts anxiety,948,Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.,"Is the triple ""Triazolam disrupts anxiety"" supported by the sentence: ""Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.""?",False, -24702695,Midazolam related to delirium,949,"The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.","Is the triple ""Midazolam related to delirium"" supported by the sentence: ""The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.""?",False, -16327495,Midazolam related to obesity disorder,950,The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.,"Is the triple ""Midazolam related to obesity disorder"" supported by the sentence: ""The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.""?",False, -17503618,Midazolam causes Nausea,951,Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.,"Is the triple ""Midazolam causes Nausea"" supported by the sentence: ""Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.""?",False, -13087342,Midazolam causes status epilepticus,952,PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.,"Is the triple ""Midazolam causes status epilepticus"" supported by the sentence: ""PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.""?",False, -12880145,Midazolam causes delirium,953,"Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.","Is the triple ""Midazolam causes delirium"" supported by the sentence: ""Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.""?",False, -12134398,Midazolam causes brain injury,954,"Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.","Is the triple ""Midazolam causes brain injury"" supported by the sentence: ""Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.""?",False, -11162624,Midazolam causes Pain,955,Sedation with midazolam leads to reduced pain after dental surgery.,"Is the triple ""Midazolam causes Pain"" supported by the sentence: ""Sedation with midazolam leads to reduced pain after dental surgery.""?",False, -10221339,Midazolam causes injury,956,"CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.","Is the triple ""Midazolam causes injury"" supported by the sentence: ""CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.""?",False, -10197463,Midazolam causes epilepsy,957,Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.,"Is the triple ""Midazolam causes epilepsy"" supported by the sentence: ""Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.""?",False, -7739374,Midazolam causes hypotensive disorder,958,"For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.","Is the triple ""Midazolam causes hypotensive disorder"" supported by the sentence: ""For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.""?",False, -7211473,Midazolam causes depressive disorder,959,We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.,"Is the triple ""Midazolam causes depressive disorder"" supported by the sentence: ""We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.""?",False, -7104276,Midazolam causes dissociative amnesia,960,"In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.","Is the triple ""Midazolam causes dissociative amnesia"" supported by the sentence: ""In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.""?",False, -27271852,Midazolam affects Pruritus,961,"In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.","Is the triple ""Midazolam affects Pruritus"" supported by the sentence: ""In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.""?",False, -26121850,Midazolam affects Pain,962,"Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.","Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.""?",False, -25522494,Midazolam affects anxiety,963,"Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.""?",False, -22514965,Midazolam affects anxiety,964,"A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.""?",False, -22203290,Midazolam affects post-traumatic stress disorder,965,The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.,"Is the triple ""Midazolam affects post-traumatic stress disorder"" supported by the sentence: ""The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.""?",False, -21411467,Midazolam affects Suicidal ideation,966,"Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).","Is the triple ""Midazolam affects Suicidal ideation"" supported by the sentence: ""Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).""?",False, -20820424,Midazolam affects injury,967,"Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.","Is the triple ""Midazolam affects injury"" supported by the sentence: ""Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.""?",False, -20230773,Midazolam affects hypotensive disorder,968,Sudden hypotension associated with midazolam and sufentanil.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""Sudden hypotension associated with midazolam and sufentanil.""?",False, -19683992,Midazolam affects injury,969,Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.,"Is the triple ""Midazolam affects injury"" supported by the sentence: ""Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.""?",False, -18986257,Midazolam affects neoplasm,970,Studies have also shown that midazolam has an anticancer effect on various tumors.,"Is the triple ""Midazolam affects neoplasm"" supported by the sentence: ""Studies have also shown that midazolam has an anticancer effect on various tumors.""?",False, -18893940,Midazolam affects hypertensive disorder,971,"Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.","Is the triple ""Midazolam affects hypertensive disorder"" supported by the sentence: ""Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.""?",False, -18670184,Midazolam affects hypotensive disorder,972,"According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.","Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.""?",False, -18644607,Midazolam affects neuralgia,973,Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.,"Is the triple ""Midazolam affects neuralgia"" supported by the sentence: ""Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.""?",False, -18331473,Midazolam affects status epilepticus,974,"The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.","Is the triple ""Midazolam affects status epilepticus"" supported by the sentence: ""The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.""?",False, -17655582,Midazolam affects Cough,975,Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.,"Is the triple ""Midazolam affects Cough"" supported by the sentence: ""Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.""?",False, -12605496,Midazolam affects dissociative amnesia,976,Midazolam tends to have more favorable effects on amnesia.,"Is the triple ""Midazolam affects dissociative amnesia"" supported by the sentence: ""Midazolam tends to have more favorable effects on amnesia.""?",False, -12154940,Midazolam affects Nausea,977,"We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.","Is the triple ""Midazolam affects Nausea"" supported by the sentence: ""We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.""?",False, -11981571,Midazolam affects delirium,978,The development of delirium was associated with the medication midazolam taken perioperatively.,"Is the triple ""Midazolam affects delirium"" supported by the sentence: ""The development of delirium was associated with the medication midazolam taken perioperatively.""?",False, -8867560,Midazolam affects Pain,979,Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.,"Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.""?",False, -8871799,Midazolam affects hypotensive disorder,980,The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.""?",False, -8701804,Midazolam affects epilepsy,981,Nasal midazolam effects on childhood acute seizures.,"Is the triple ""Midazolam affects epilepsy"" supported by the sentence: ""Nasal midazolam effects on childhood acute seizures.""?",False, -8569605,Midazolam affects brain injury,982,"Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.","Is the triple ""Midazolam affects brain injury"" supported by the sentence: ""Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.""?",False, -7116661,Midazolam affects Postoperative Nausea and Vomiting,983,The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.,"Is the triple ""Midazolam affects Postoperative Nausea and Vomiting"" supported by the sentence: ""The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.""?",False, -20025306,Midazolam disrupts Pruritus,984,"Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.","Is the triple ""Midazolam disrupts Pruritus"" supported by the sentence: ""Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.""?",False, -18424847,Midazolam disrupts status epilepticus,985,"Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.","Is the triple ""Midazolam disrupts status epilepticus"" supported by the sentence: ""Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.""?",False, -16150704,Midazolam disrupts Cough,986,CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.,"Is the triple ""Midazolam disrupts Cough"" supported by the sentence: ""CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.""?",False, -14733481,Midazolam disrupts neuralgia,987,Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.,"Is the triple ""Midazolam disrupts neuralgia"" supported by the sentence: ""Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.""?",False, -13861580,Midazolam disrupts Pain,988,"CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.","Is the triple ""Midazolam disrupts Pain"" supported by the sentence: ""CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.""?",False, -9443524,Midazolam disrupts epilepsy,989,"PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.","Is the triple ""Midazolam disrupts epilepsy"" supported by the sentence: ""PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.""?",False, -7819099,Midazolam disrupts anxiety,990,CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.,"Is the triple ""Midazolam disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.""?",False, -21663738,Midazolam prevents anxiety,991,This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.,"Is the triple ""Midazolam prevents anxiety"" supported by the sentence: ""This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.""?",False, -20820423,Midazolam prevents injury,992,Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.,"Is the triple ""Midazolam prevents injury"" supported by the sentence: ""Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.""?",False, -17322994,Midazolam prevents Aggressive behavior,993,"Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.","Is the triple ""Midazolam prevents Aggressive behavior"" supported by the sentence: ""Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.""?",False, -16397367,Midazolam prevents status epilepticus,994,"Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.","Is the triple ""Midazolam prevents status epilepticus"" supported by the sentence: ""Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.""?",False, -13467675,Midazolam prevents Nausea,995,Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.,"Is the triple ""Midazolam prevents Nausea"" supported by the sentence: ""Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.""?",False, -11373548,Midazolam prevents Cough,996,"CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.","Is the triple ""Midazolam prevents Cough"" supported by the sentence: ""CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.""?",False, -11041799,Midazolam prevents bone fracture,997,"Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.","Is the triple ""Midazolam prevents bone fracture"" supported by the sentence: ""Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.""?",False, -9493413,Midazolam prevents epilepsy,998,"Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.","Is the triple ""Midazolam prevents epilepsy"" supported by the sentence: ""Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.""?",False, -8653279,Midazolam prevents Sepsis,999,"Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.","Is the triple ""Midazolam prevents Sepsis"" supported by the sentence: ""Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.""?",False, -8569600,Midazolam prevents brain injury,1000,"Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.","Is the triple ""Midazolam prevents brain injury"" supported by the sentence: ""Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.""?",False, -8151023,Midazolam prevents Pain,1001,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Midazolam prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, -7116663,Midazolam prevents Postoperative Nausea and Vomiting,1002,We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.,"Is the triple ""Midazolam prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.""?",False, -16657523,Midazolam exacerbates Sepsis,1003,"METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.","Is the triple ""Midazolam exacerbates Sepsis"" supported by the sentence: ""METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.""?",False, -19191198,Midazolam predisposes dissociative amnesia,1004,This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.,"Is the triple ""Midazolam predisposes dissociative amnesia"" supported by the sentence: ""This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.""?",False, -18422952,Midazolam predisposes status epilepticus,1005,"Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.","Is the triple ""Midazolam predisposes status epilepticus"" supported by the sentence: ""Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.""?",False, -11981572,Midazolam predisposes delirium,1006,The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.,"Is the triple ""Midazolam predisposes delirium"" supported by the sentence: ""The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.""?",False, -22402246,Brotizolam disrupts anxiety,1007,"Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.","Is the triple ""Brotizolam disrupts anxiety"" supported by the sentence: ""Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.""?",False, -12312025,Ganirelix related to polycystic ovary syndrome,1008,LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.,"Is the triple ""Ganirelix related to polycystic ovary syndrome"" supported by the sentence: ""LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.""?",False, -14831488,Cetrorelix disrupts benign prostatic hyperplasia,1009,Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.,"Is the triple ""Cetrorelix disrupts benign prostatic hyperplasia"" supported by the sentence: ""Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.""?",False, -18703871,Cetrorelix prevents endometriosis,1010,"CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.","Is the triple ""Cetrorelix prevents endometriosis"" supported by the sentence: ""CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.""?",False, -18874469,Methoxsalen related to Deoxyribonucleic acid,1011,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, -18874469,Methoxsalen related to Deoxyribonucleic acid,1012,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, -12069194,Methoxsalen related to mycosis fungoides,1013,Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.,"Is the triple ""Methoxsalen related to mycosis fungoides"" supported by the sentence: ""Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.""?",False, -8610329,Methoxsalen related to psoriasis,1014,"Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.","Is the triple ""Methoxsalen related to psoriasis"" supported by the sentence: ""Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.""?",False, -26218137,Methoxsalen related to Deoxyribonucleic acid,1015,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, -26218137,Methoxsalen related to Deoxyribonucleic acid,1016,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, -7172075,Methoxsalen coexists with Deoxyribonucleic acid,1017,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, -7172075,Methoxsalen coexists with Deoxyribonucleic acid,1018,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, -26761340,Methoxsalen coexists with Deoxyribonucleic acid,1019,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, -26761340,Methoxsalen coexists with Deoxyribonucleic acid,1020,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, -7782040,Methoxsalen physically interacts with Deoxyribonucleic acid,1021,"New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.","Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.""?",False, -12022213,Methoxsalen physically interacts with Deoxyribonucleic acid,1022,MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.,"Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.""?",False, -9512596,Methoxsalen affects Deoxyribonucleic acid,1023,"Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.""?",False, -19709381,Methoxsalen affects Deoxyribonucleic acid,1024,"Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.""?",False, -8674128,Trioxsalen coexists with Deoxyribonucleic acid,1025,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, -8674128,Trioxsalen coexists with Deoxyribonucleic acid,1026,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, -8674127,Trioxsalen physically interacts with Deoxyribonucleic acid,1027,"In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.","Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.""?",False, -25732039,Trioxsalen physically interacts with Deoxyribonucleic acid,1028,The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.,"Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.""?",False, -16826513,Trioxsalen affects Deoxyribonucleic acid,1029,"Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.","Is the triple ""Trioxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.""?",False, -9717834,Bisoprolol related to hypertensive disorder,1030,"Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.","Is the triple ""Bisoprolol related to hypertensive disorder"" supported by the sentence: ""Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.""?",False, -17484309,Bisoprolol affects Hemorrhage,1031,CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.,"Is the triple ""Bisoprolol affects Hemorrhage"" supported by the sentence: ""CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.""?",False, -14633716,Bisoprolol affects hypertensive disorder,1032,CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.,"Is the triple ""Bisoprolol affects hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.""?",False, -13150765,Bisoprolol affects pulmonary arterial hypertension,1033,"MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.","Is the triple ""Bisoprolol affects pulmonary arterial hypertension"" supported by the sentence: ""MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.""?",False, -24626572,Bisoprolol disrupts Hemorrhage,1034,No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.,"Is the triple ""Bisoprolol disrupts Hemorrhage"" supported by the sentence: ""No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.""?",False, -23315135,Bisoprolol prevents Hemorrhage,1035,"Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).","Is the triple ""Bisoprolol prevents Hemorrhage"" supported by the sentence: ""Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).""?",False, -26817035,Esmolol related to atrial fibrillation,1036,"In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.","Is the triple ""Esmolol related to atrial fibrillation"" supported by the sentence: ""In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.""?",False, -13689489,Esmolol causes atrial fibrillation,1037,Esmolol or atropine markedly increased the threshold for AF induction.,"Is the triple ""Esmolol causes atrial fibrillation"" supported by the sentence: ""Esmolol or atropine markedly increased the threshold for AF induction.""?",False, -20072391,Esmolol affects toxic shock syndrome,1038,The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.,"Is the triple ""Esmolol affects toxic shock syndrome"" supported by the sentence: ""The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.""?",False, -19519833,Esmolol affects Pain,1039,"Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.","Is the triple ""Esmolol affects Pain"" supported by the sentence: ""Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.""?",False, -16877299,Esmolol prevents Pain,1040,Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.,"Is the triple ""Esmolol prevents Pain"" supported by the sentence: ""Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.""?",False, -10180097,Esmolol prevents ischemia reperfusion injury,1041,"Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.","Is the triple ""Esmolol prevents ischemia reperfusion injury"" supported by the sentence: ""Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.""?",False, -9581320,Esmolol prevents atrial fibrillation,1042,We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.,"Is the triple ""Esmolol prevents atrial fibrillation"" supported by the sentence: ""We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.""?",False, -18235527,Oxygen related to pulmonary fibrosis,1043,"However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.","Is the triple ""Oxygen related to pulmonary fibrosis"" supported by the sentence: ""However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.""?",False, -18193743,Oxygen related to neoplasm,1044,Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.,"Is the triple ""Oxygen related to neoplasm"" supported by the sentence: ""Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.""?",False, -17303485,Oxygen related to Hypoxemia,1045,"CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.","Is the triple ""Oxygen related to Hypoxemia"" supported by the sentence: ""CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.""?",False, -14116536,Oxygen related to Shock,1046,The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.,"Is the triple ""Oxygen related to Shock"" supported by the sentence: ""The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.""?",False, -13587155,Oxygen related to injury,1047,These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.,"Is the triple ""Oxygen related to injury"" supported by the sentence: ""These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.""?",False, -8813011,Oxygen related to ischemia reperfusion injury,1048,Cardiac toxicity of singlet oxygen: implication in reperfusion injury.,"Is the triple ""Oxygen related to ischemia reperfusion injury"" supported by the sentence: ""Cardiac toxicity of singlet oxygen: implication in reperfusion injury.""?",False, -21893162,Oxygen causes neoplasm,1049,"Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.","Is the triple ""Oxygen causes neoplasm"" supported by the sentence: ""Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.""?",False, -19992109,Oxygen causes ischemia reperfusion injury,1050,The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.,"Is the triple ""Oxygen causes ischemia reperfusion injury"" supported by the sentence: ""The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.""?",False, -8243272,Oxygen causes vascular disorder,1051,"Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.","Is the triple ""Oxygen causes vascular disorder"" supported by the sentence: ""Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.""?",False, -8114891,Oxygen causes injury,1052,New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.,"Is the triple ""Oxygen causes injury"" supported by the sentence: ""New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.""?",False, -7992845,Oxygen causes Hypoxemia,1053,"At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.","Is the triple ""Oxygen causes Hypoxemia"" supported by the sentence: ""At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.""?",False, -7752235,Oxygen causes stroke disorder,1054,We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.,"Is the triple ""Oxygen causes stroke disorder"" supported by the sentence: ""We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.""?",False, -23272853,Oxygen affects neoplasm,1055,"The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.""?",False, -22206348,Oxygen affects neoplasm,1056,"Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.""?",False, -19397332,Oxygen affects Hypoxemia,1057,"Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.","Is the triple ""Oxygen affects Hypoxemia"" supported by the sentence: ""Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.""?",False, -13060611,Oxygen affects Shock,1058,Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.,"Is the triple ""Oxygen affects Shock"" supported by the sentence: ""Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.""?",False, -13638133,Oxygen produces Hypoxemia,1059,"However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.","Is the triple ""Oxygen produces Hypoxemia"" supported by the sentence: ""However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.""?",False, -13264427,Oxygen produces neoplasm,1060,"The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.","Is the triple ""Oxygen produces neoplasm"" supported by the sentence: ""The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.""?",False, -12483211,Oxygen disrupts Hypoxemia,1061,Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.,"Is the triple ""Oxygen disrupts Hypoxemia"" supported by the sentence: ""Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.""?",False, -11682185,Oxygen disrupts neoplasm,1062,"While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.","Is the triple ""Oxygen disrupts neoplasm"" supported by the sentence: ""While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.""?",False, -16806319,Oxygen prevents injury,1063,"Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.","Is the triple ""Oxygen prevents injury"" supported by the sentence: ""Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.""?",False, -17280500,Oxygen predisposes injury,1064,"Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.","Is the triple ""Oxygen predisposes injury"" supported by the sentence: ""Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.""?",False, -7575686,Metoprolol subclass of O-Demethylmetoprolol,1065,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of O-Demethylmetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, -7575685,Metoprolol subclass of alpha-Hydroxymetoprolol,1066,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of alpha-Hydroxymetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, -27359356,Metoprolol related to alpha-Hydroxymetoprolol,1067,"When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.","Is the triple ""Metoprolol related to alpha-Hydroxymetoprolol"" supported by the sentence: ""When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.""?",False, -27639377,Metoprolol derives from alpha-Hydroxymetoprolol,1068,"METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.","Is the triple ""Metoprolol derives from alpha-Hydroxymetoprolol"" supported by the sentence: ""METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.""?",False, -26548288,Metoprolol physically interacts with O-Demethylmetoprolol,1069,"Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.","Is the triple ""Metoprolol physically interacts with O-Demethylmetoprolol"" supported by the sentence: ""Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.""?",False, -21656554,Metoprolol physically interacts with alpha-Hydroxymetoprolol,1070,Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.,"Is the triple ""Metoprolol physically interacts with alpha-Hydroxymetoprolol"" supported by the sentence: ""Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.""?",False, -27101524,Metoprolol causes ventricular tachycardia,1071,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular tachycardia"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, -27101519,Metoprolol causes ventricular fibrillation,1072,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular fibrillation"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, -20648435,Metoprolol causes cardiac rhythm disease,1073,"Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.","Is the triple ""Metoprolol causes cardiac rhythm disease"" supported by the sentence: ""Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.""?",False, -14625318,Metoprolol causes hypertensive disorder,1074,[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].,"Is the triple ""Metoprolol causes hypertensive disorder"" supported by the sentence: ""[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].""?",False, -19013861,Metoprolol affects obesity disorder,1075,"Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.","Is the triple ""Metoprolol affects obesity disorder"" supported by the sentence: ""Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.""?",False, -17630974,Metoprolol affects coronary artery disorder,1076,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects coronary artery disorder"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, -17630973,Metoprolol affects atherosclerosis,1077,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects atherosclerosis"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, -16547648,Metoprolol affects myocardial infarction,1078,Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.,"Is the triple ""Metoprolol affects myocardial infarction"" supported by the sentence: ""Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.""?",False, -12751741,Metoprolol affects cardiac rhythm disease,1079,"Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.","Is the triple ""Metoprolol affects cardiac rhythm disease"" supported by the sentence: ""Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.""?",False, -11341339,Metoprolol affects hypertensive disorder,1080,The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).,"Is the triple ""Metoprolol affects hypertensive disorder"" supported by the sentence: ""The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).""?",False, -16802112,Metoprolol disrupts atrial fibrillation,1081,CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.,"Is the triple ""Metoprolol disrupts atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.""?",False, -14314818,Metoprolol disrupts atherosclerosis,1082,"These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.","Is the triple ""Metoprolol disrupts atherosclerosis"" supported by the sentence: ""These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.""?",False, -13648308,Metoprolol disrupts ventricular tachycardia,1083,Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.,"Is the triple ""Metoprolol disrupts ventricular tachycardia"" supported by the sentence: ""Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.""?",False, -12510783,Metoprolol disrupts cardiac rhythm disease,1084,"However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.","Is the triple ""Metoprolol disrupts cardiac rhythm disease"" supported by the sentence: ""However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.""?",False, -16624344,Metoprolol prevents cardiac rhythm disease,1085,Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.,"Is the triple ""Metoprolol prevents cardiac rhythm disease"" supported by the sentence: ""Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.""?",False, -13530896,Metoprolol prevents myocardial infarction,1086,"POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.","Is the triple ""Metoprolol prevents myocardial infarction"" supported by the sentence: ""POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.""?",False, -13366014,Metoprolol prevents hypertensive disorder,1087,Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.,"Is the triple ""Metoprolol prevents hypertensive disorder"" supported by the sentence: ""Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.""?",False, -13268090,Metoprolol prevents ventricular fibrillation,1088,"CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.","Is the triple ""Metoprolol prevents ventricular fibrillation"" supported by the sentence: ""CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.""?",False, -9428080,Metoprolol prevents atrial fibrillation,1089,Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.,"Is the triple ""Metoprolol prevents atrial fibrillation"" supported by the sentence: ""Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.""?",False, -7236533,Metoprolol prevents atherosclerosis,1090,"The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.","Is the triple ""Metoprolol prevents atherosclerosis"" supported by the sentence: ""The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.""?",False, -22663349,Metoprolol predisposes atrial fibrillation,1091,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Metoprolol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, -25990864,Acebutolol affects hypertensive disorder,1092,The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.,"Is the triple ""Acebutolol affects hypertensive disorder"" supported by the sentence: ""The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.""?",False, -25995365,Acebutolol prevents hypertensive disorder,1093,"Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.","Is the triple ""Acebutolol prevents hypertensive disorder"" supported by the sentence: ""Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.""?",False, -24856753,Pretomanid affects multidrug-resistant tuberculosis,1094,"Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.","Is the triple ""Pretomanid affects multidrug-resistant tuberculosis"" supported by the sentence: ""Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.""?",False, -17848125,Nitrogen related to chronic obstructive pulmonary disease,1095,"Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.","Is the triple ""Nitrogen related to chronic obstructive pulmonary disease"" supported by the sentence: ""Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.""?",False, -15192685,Nitrogen related to ischemia reperfusion injury,1096,"Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.","Is the triple ""Nitrogen related to ischemia reperfusion injury"" supported by the sentence: ""Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.""?",False, -10505101,Nitrogen related to burn,1097,The effect on the nitrogen metabolism of severely burned patients.,"Is the triple ""Nitrogen related to burn"" supported by the sentence: ""The effect on the nitrogen metabolism of severely burned patients.""?",False, -10425490,Nitrogen related to cystic fibrosis,1098,Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.,"Is the triple ""Nitrogen related to cystic fibrosis"" supported by the sentence: ""Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.""?",False, -16934805,Nitrogen causes ischemia reperfusion injury,1099,"METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.","Is the triple ""Nitrogen causes ischemia reperfusion injury"" supported by the sentence: ""METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.""?",False, -13030867,Nitrogen affects ischemia reperfusion injury,1100,Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.,"Is the triple ""Nitrogen affects ischemia reperfusion injury"" supported by the sentence: ""Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.""?",False, -9020164,Nitrogen affects severe acute respiratory syndrome,1101,"The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.","Is the triple ""Nitrogen affects severe acute respiratory syndrome"" supported by the sentence: ""The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.""?",False, -17493096,Nitrogen predisposes ischemia reperfusion injury,1102,BACKGROUND: Nitrogen may contribute to reperfusion injury.,"Is the triple ""Nitrogen predisposes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Nitrogen may contribute to reperfusion injury.""?",False, -25313239,Helium related to status asthmaticus,1103,[Use of helium and oxygen mixtures in status asthmaticus].,"Is the triple ""Helium related to status asthmaticus"" supported by the sentence: ""[Use of helium and oxygen mixtures in status asthmaticus].""?",False, -12274245,Helium related to chronic obstructive pulmonary disease,1104,The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.,"Is the triple ""Helium related to chronic obstructive pulmonary disease"" supported by the sentence: ""The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.""?",False, -15248421,Carbon Dioxide related to Pain,1105,"Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.","Is the triple ""Carbon Dioxide related to Pain"" supported by the sentence: ""Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.""?",False, -11844945,Carbon Dioxide related to sleep apnea syndrome,1106,"Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.","Is the triple ""Carbon Dioxide related to sleep apnea syndrome"" supported by the sentence: ""Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.""?",False, -10575797,Carbon Dioxide related to respiratory failure,1107,Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.,"Is the triple ""Carbon Dioxide related to respiratory failure"" supported by the sentence: ""Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.""?",False, -7620110,Carbon Dioxide related to panic disorder,1108,To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.,"Is the triple ""Carbon Dioxide related to panic disorder"" supported by the sentence: ""To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.""?",False, -16671036,Carbon Dioxide causes panic disorder,1109,"We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.","Is the triple ""Carbon Dioxide causes panic disorder"" supported by the sentence: ""We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.""?",False, -11038318,Carbon Dioxide causes respiratory failure,1110,"BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.","Is the triple ""Carbon Dioxide causes respiratory failure"" supported by the sentence: ""BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.""?",False, -20071308,Carbon Dioxide affects Pain,1111,"INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.","Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.""?",False, -15771768,Carbon Dioxide affects Pain,1112,Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.,"Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.""?",False, -15385933,Carbon Dioxide affects panic disorder,1113,"In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.","Is the triple ""Carbon Dioxide affects panic disorder"" supported by the sentence: ""In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.""?",False, -14460813,Carbon Dioxide affects respiratory failure,1114,"Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.","Is the triple ""Carbon Dioxide affects respiratory failure"" supported by the sentence: ""Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.""?",False, -15294247,Carbon Dioxide produces respiratory failure,1115,"As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.","Is the triple ""Carbon Dioxide produces respiratory failure"" supported by the sentence: ""As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.""?",False, -11946282,Carbon Dioxide disrupts Pain,1116,BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.,"Is the triple ""Carbon Dioxide disrupts Pain"" supported by the sentence: ""BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.""?",False, -17126447,Carbon Dioxide predisposes Pain,1117,OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.,"Is the triple ""Carbon Dioxide predisposes Pain"" supported by the sentence: ""OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.""?",False, -11404382,Carbon Dioxide predisposes panic disorder,1118,"Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.","Is the triple ""Carbon Dioxide predisposes panic disorder"" supported by the sentence: ""Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.""?",False, -7432027,Carbon Dioxide predisposes respiratory failure,1119,"At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.","Is the triple ""Carbon Dioxide predisposes respiratory failure"" supported by the sentence: ""At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.""?",False, -24776228,Ethambutol causes tuberculosis,1120,From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.,"Is the triple ""Ethambutol causes tuberculosis"" supported by the sentence: ""From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.""?",False, -25946331,Ethambutol affects tuberculosis,1121,Effects of ethambutol on tuberculous diseases of the eye.,"Is the triple ""Ethambutol affects tuberculosis"" supported by the sentence: ""Effects of ethambutol on tuberculous diseases of the eye.""?",False, -24875144,Ethambutol affects pulmonary tuberculosis,1122,Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).,"Is the triple ""Ethambutol affects pulmonary tuberculosis"" supported by the sentence: ""Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).""?",False, -25597027,Ethambutol disrupts tuberculosis,1123,Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.,"Is the triple ""Ethambutol disrupts tuberculosis"" supported by the sentence: ""Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.""?",False, -18704735,Ethambutol prevents tuberculosis,1124,"After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.","Is the triple ""Ethambutol prevents tuberculosis"" supported by the sentence: ""After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.""?",False, -14472959,Pyrazinamide affects pulmonary tuberculosis,1125,Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.,"Is the triple ""Pyrazinamide affects pulmonary tuberculosis"" supported by the sentence: ""Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.""?",False, -10149898,Pyrazinamide affects tuberculosis,1126,Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.,"Is the triple ""Pyrazinamide affects tuberculosis"" supported by the sentence: ""Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.""?",False, -8080030,Pyrazinamide prevents tuberculosis,1127,Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.,"Is the triple ""Pyrazinamide prevents tuberculosis"" supported by the sentence: ""Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.""?",False, -27556045,Pyrazinamide predisposes tuberculosis,1128,"The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.","Is the triple ""Pyrazinamide predisposes tuberculosis"" supported by the sentence: ""The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.""?",False, -26376727,Androstanolone related to hypogonadism,1129,"The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.","Is the triple ""Androstanolone related to hypogonadism"" supported by the sentence: ""The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.""?",False, -22807780,Androstanolone affects hypogonadism,1130,"In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.","Is the triple ""Androstanolone affects hypogonadism"" supported by the sentence: ""In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.""?",False, -7261548,Nebivolol related to essential hypertension,1131,Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.,"Is the triple ""Nebivolol related to essential hypertension"" supported by the sentence: ""Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.""?",False, -10251853,Nebivolol affects hypertensive disorder,1132,In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.,"Is the triple ""Nebivolol affects hypertensive disorder"" supported by the sentence: ""In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.""?",False, -20026875,Nebivolol prevents cardiovascular disorder,1133,Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.,"Is the triple ""Nebivolol prevents cardiovascular disorder"" supported by the sentence: ""Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.""?",False, -10251855,Nebivolol prevents hypertensive disorder,1134,These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.,"Is the triple ""Nebivolol prevents hypertensive disorder"" supported by the sentence: ""These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.""?",False, -11558481,Nebivolol exacerbates hypertensive disorder,1135,"Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.","Is the triple ""Nebivolol exacerbates hypertensive disorder"" supported by the sentence: ""Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.""?",False, -17527026,Landiolol related to atrial fibrillation,1136,INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.,"Is the triple ""Landiolol related to atrial fibrillation"" supported by the sentence: ""INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.""?",False, -14267268,Landiolol affects atrial fibrillation,1137,The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.,"Is the triple ""Landiolol affects atrial fibrillation"" supported by the sentence: ""The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.""?",False, -16074351,Landiolol disrupts atrial fibrillation,1138,"RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).","Is the triple ""Landiolol disrupts atrial fibrillation"" supported by the sentence: ""RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).""?",False, -21882778,Landiolol prevents cardiac rhythm disease,1139,INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.,"Is the triple ""Landiolol prevents cardiac rhythm disease"" supported by the sentence: ""INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.""?",False, -14873276,Landiolol prevents atrial fibrillation,1140,"Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.","Is the triple ""Landiolol prevents atrial fibrillation"" supported by the sentence: ""Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.""?",False, -20190145,Landiolol predisposes atrial fibrillation,1141,"In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.","Is the triple ""Landiolol predisposes atrial fibrillation"" supported by the sentence: ""In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.""?",False, -26530979,Oxandrolone related to nutritional disorder,1142,"For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.","Is the triple ""Oxandrolone related to nutritional disorder"" supported by the sentence: ""For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.""?",False, -17138340,Oxandrolone related to Fanconi anemia,1143,"CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.","Is the triple ""Oxandrolone related to Fanconi anemia"" supported by the sentence: ""CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.""?",False, -12117784,Oxandrolone related to Turner syndrome,1144,"Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.","Is the triple ""Oxandrolone related to Turner syndrome"" supported by the sentence: ""Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.""?",False, -11269262,Oxandrolone related to burn,1145,The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.,"Is the triple ""Oxandrolone related to burn"" supported by the sentence: ""The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.""?",False, -7561027,Cefepime causes toxic shock syndrome,1146,"Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.","Is the triple ""Cefepime causes toxic shock syndrome"" supported by the sentence: ""Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.""?",False, -19437692,Cefepime affects bacterial infectious disease,1147,"OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.","Is the triple ""Cefepime affects bacterial infectious disease"" supported by the sentence: ""OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.""?",False, -17947468,Cefepime affects infectious disease,1148,"CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.","Is the triple ""Cefepime affects infectious disease"" supported by the sentence: ""CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.""?",False, -19800344,Cefepime disrupts infectious disease,1149,"CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.","Is the triple ""Cefepime disrupts infectious disease"" supported by the sentence: ""CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.""?",False, -26336145,"Hydrocortisone butyrate related to dermatitis, atopic",1150,[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].,"Is the triple ""Hydrocortisone butyrate related to dermatitis, atopic"" supported by the sentence: ""[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].""?",False, -26243703,Hydrocortisone butyrate related to skin disorder,1151,[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].,"Is the triple ""Hydrocortisone butyrate related to skin disorder"" supported by the sentence: ""[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].""?",False, -25968096,Hydrocortisone butyrate related to psoriasis,1152,Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.,"Is the triple ""Hydrocortisone butyrate related to psoriasis"" supported by the sentence: ""Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.""?",False, -17603464,Hydrocortisone butyrate disrupts psoriasis,1153,"Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.","Is the triple ""Hydrocortisone butyrate disrupts psoriasis"" supported by the sentence: ""Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.""?",False, -9729745,Adapalene related to acne,1154,The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.,"Is the triple ""Adapalene related to acne"" supported by the sentence: ""The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.""?",False, -8571018,Adapalene physically interacts with Retinoic Acid Receptor,1155,Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.,"Is the triple ""Adapalene physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.""?",False, -13523825,Retinol related to eye disorder,1156,"A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.","Is the triple ""Retinol related to eye disorder"" supported by the sentence: ""A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.""?",False, -11015290,Retinol related to tuberculosis,1157,[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].,"Is the triple ""Retinol related to tuberculosis"" supported by the sentence: ""[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].""?",False, -10457909,Retinol related to acne,1158,Vitamin A in acne vulgaris.,"Is the triple ""Retinol related to acne"" supported by the sentence: ""Vitamin A in acne vulgaris.""?",False, -8518043,Retinol related to malaria,1159,Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.,"Is the triple ""Retinol related to malaria"" supported by the sentence: ""Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.""?",False, -8137103,Retinol related to vitamin A deficiency,1160,"CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.","Is the triple ""Retinol related to vitamin A deficiency"" supported by the sentence: ""CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.""?",False, -7807614,Retinol related to retinitis pigmentosa,1161,"Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.","Is the triple ""Retinol related to retinitis pigmentosa"" supported by the sentence: ""Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.""?",False, -9304322,Retinol causes malaria,1162,"Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).","Is the triple ""Retinol causes malaria"" supported by the sentence: ""Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).""?",False, -27090494,Retinol affects diarrheal disease,1163,"However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.","Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.""?",False, -21959378,Retinol affects nutritional disorder,1164,Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.,"Is the triple ""Retinol affects nutritional disorder"" supported by the sentence: ""Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.""?",False, -17401879,Retinol affects tuberculosis,1165,"Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.","Is the triple ""Retinol affects tuberculosis"" supported by the sentence: ""Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.""?",False, -17082512,Retinol affects acne,1166,"Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.","Is the triple ""Retinol affects acne"" supported by the sentence: ""Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.""?",False, -12962972,Retinol affects eye disorder,1167,"The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.","Is the triple ""Retinol affects eye disorder"" supported by the sentence: ""The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.""?",False, -12534891,Retinol affects vitamin A deficiency,1168,The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.,"Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.""?",False, -11508263,Retinol affects diarrheal disease,1169,OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.,"Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.""?",False, -10941106,Retinol affects vitamin A deficiency,1170,"Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.","Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.""?",False, -22325993,Retinol produces Infection,1171,"As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).","Is the triple ""Retinol produces Infection"" supported by the sentence: ""As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).""?",False, -23772860,Retinol disrupts vitamin A deficiency,1172,"Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.","Is the triple ""Retinol disrupts vitamin A deficiency"" supported by the sentence: ""Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.""?",False, -12105339,Retinol disrupts diarrheal disease,1173,"Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.","Is the triple ""Retinol disrupts diarrheal disease"" supported by the sentence: ""Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.""?",False, -24823924,Retinol prevents Infection,1174,Vitamin A protects against infections and maintains epithelial integrity.,"Is the triple ""Retinol prevents Infection"" supported by the sentence: ""Vitamin A protects against infections and maintains epithelial integrity.""?",False, -17332605,Retinol prevents malaria,1175,CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.,"Is the triple ""Retinol prevents malaria"" supported by the sentence: ""CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.""?",False, -11445573,Retinol prevents nutritional disorder,1176,"Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.","Is the triple ""Retinol prevents nutritional disorder"" supported by the sentence: ""Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.""?",False, -8153477,Retinol prevents diarrheal disease,1177,"BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.","Is the triple ""Retinol prevents diarrheal disease"" supported by the sentence: ""BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.""?",False, -23860384,Retinol predisposes nutritional disorder,1178,"The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.","Is the triple ""Retinol predisposes nutritional disorder"" supported by the sentence: ""The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.""?",False, -19923430,Retinol predisposes malaria,1179,"We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.","Is the triple ""Retinol predisposes malaria"" supported by the sentence: ""We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.""?",False, -16391363,Retinol predisposes tuberculosis,1180,"A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.","Is the triple ""Retinol predisposes tuberculosis"" supported by the sentence: ""A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.""?",False, -15050082,Retinol predisposes diarrheal disease,1181,"Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.","Is the triple ""Retinol predisposes diarrheal disease"" supported by the sentence: ""Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.""?",False, -9744244,Retinol predisposes vitamin A deficiency,1182,"VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.","Is the triple ""Retinol predisposes vitamin A deficiency"" supported by the sentence: ""VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.""?",False, -18962170,Isotretinoin related to neuroblastoma,1183,We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.,"Is the triple ""Isotretinoin related to neuroblastoma"" supported by the sentence: ""We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.""?",False, -16229483,Isotretinoin related to brain cancer,1184,"Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.","Is the triple ""Isotretinoin related to brain cancer"" supported by the sentence: ""Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.""?",False, -15225681,Isotretinoin related to acne,1185,"The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.","Is the triple ""Isotretinoin related to acne"" supported by the sentence: ""The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.""?",False, -14091563,Isotretinoin related to myelodysplastic syndrome,1186,Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.,"Is the triple ""Isotretinoin related to myelodysplastic syndrome"" supported by the sentence: ""Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.""?",False, -9061344,Isotretinoin related to renal cell carcinoma,1187,BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).,"Is the triple ""Isotretinoin related to renal cell carcinoma"" supported by the sentence: ""BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).""?",False, -11768316,Isotretinoin physically interacts with Retinoic Acid Receptor,1188,"The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.","Is the triple ""Isotretinoin physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.""?",False, -21199868,Isotretinoin causes neuroblastoma,1189,"We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.","Is the triple ""Isotretinoin causes neuroblastoma"" supported by the sentence: ""We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.""?",False, -19803622,Isotretinoin causes acne,1190,Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.,"Is the triple ""Isotretinoin causes acne"" supported by the sentence: ""Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.""?",False, -19310397,Isotretinoin causes breast neoplasm,1191,Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.,"Is the triple ""Isotretinoin causes breast neoplasm"" supported by the sentence: ""Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.""?",False, -13522698,Isotretinoin causes neoplasm,1192,"We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.","Is the triple ""Isotretinoin causes neoplasm"" supported by the sentence: ""We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.""?",False, -23934527,Isotretinoin affects neoplasm,1193,"Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.""?",False, -20382078,Isotretinoin affects neuroblastoma,1194,"To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.","Is the triple ""Isotretinoin affects neuroblastoma"" supported by the sentence: ""To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.""?",False, -15927367,Isotretinoin affects rosacea,1195,"Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.","Is the triple ""Isotretinoin affects rosacea"" supported by the sentence: ""Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.""?",False, -15330626,Isotretinoin affects acne,1196,"In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.","Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.""?",False, -11212975,Isotretinoin affects neoplasm,1197,"CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.""?",False, -9764204,Isotretinoin affects acne,1198,Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.,"Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.""?",False, -21476432,Isotretinoin disrupts neuroblastoma,1199,Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.,"Is the triple ""Isotretinoin disrupts neuroblastoma"" supported by the sentence: ""Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.""?",False, -14724193,Isotretinoin disrupts neoplasm,1200,"Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.","Is the triple ""Isotretinoin disrupts neoplasm"" supported by the sentence: ""Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.""?",False, -14863864,Isotretinoin prevents acne,1201,"The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.","Is the triple ""Isotretinoin prevents acne"" supported by the sentence: ""The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.""?",False, -8312321,Isotretinoin prevents neoplasm,1202,Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.,"Is the triple ""Isotretinoin prevents neoplasm"" supported by the sentence: ""Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.""?",False, -15444114,Isotretinoin exacerbates ichthyosis,1203,We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.,"Is the triple ""Isotretinoin exacerbates ichthyosis"" supported by the sentence: ""We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.""?",False, -15310461,Isotretinoin predisposes acne,1204,"OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.","Is the triple ""Isotretinoin predisposes acne"" supported by the sentence: ""OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.""?",False, -24593446,Trifarotene affects acne,1205,The current review evaluates the role of trifarotene in treating acne.,"Is the triple ""Trifarotene affects acne"" supported by the sentence: ""The current review evaluates the role of trifarotene in treating acne.""?",False, -21448312,Atazanavir affects AIDS,1206,Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?,"Is the triple ""Atazanavir affects AIDS"" supported by the sentence: ""Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?""?",False, -24947472,Atazanavir disrupts HIV infectious disease,1207,"This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.","Is the triple ""Atazanavir disrupts HIV infectious disease"" supported by the sentence: ""This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.""?",False, -13198660,Atazanavir disrupts AIDS,1208,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Atazanavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, -20253995,Atazanavir prevents AIDS,1209,"Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.","Is the triple ""Atazanavir prevents AIDS"" supported by the sentence: ""Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.""?",False, -8134603,Saquinavir affects HIV infectious disease,1210,The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.,"Is the triple ""Saquinavir affects HIV infectious disease"" supported by the sentence: ""The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.""?",False, -16320598,Saquinavir disrupts viral infectious disease,1211,"SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.","Is the triple ""Saquinavir disrupts viral infectious disease"" supported by the sentence: ""SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.""?",False, -13198658,Saquinavir disrupts AIDS,1212,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Saquinavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, -17107608,Saquinavir prevents HIV infectious disease,1213,The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.,"Is the triple ""Saquinavir prevents HIV infectious disease"" supported by the sentence: ""The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.""?",False, -12560548,Indinavir prevents viral infectious disease,1214,Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.,"Is the triple ""Indinavir prevents viral infectious disease"" supported by the sentence: ""Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.""?",False, -15113750,Ritonavir related to AIDS,1215,Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.,"Is the triple ""Ritonavir related to AIDS"" supported by the sentence: ""Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.""?",False, -7566746,Ritonavir related to Cytochrome P-450 CYP3A,1216,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, -7566746,Ritonavir related to Cytochrome P-450 CYP3A,1217,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, -15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1218,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, -15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1219,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, -11500913,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1220,"In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).""?",False, -8329957,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1221,"Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.""?",False, -8452370,Ritonavir causes AIDS,1222,"Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.","Is the triple ""Ritonavir causes AIDS"" supported by the sentence: ""Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.""?",False, -21492333,Ritonavir affects neoplasm,1223,Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.,"Is the triple ""Ritonavir affects neoplasm"" supported by the sentence: ""Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.""?",False, -12140603,Ritonavir affects Insulin resistance,1224,"All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.","Is the triple ""Ritonavir affects Insulin resistance"" supported by the sentence: ""All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.""?",False, -9520105,Ritonavir affects HIV infectious disease,1225,This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.,"Is the triple ""Ritonavir affects HIV infectious disease"" supported by the sentence: ""This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.""?",False, -7566745,Ritonavir affects Cytochrome P-450 CYP3A,1226,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, -15873481,Ritonavir affects Cytochrome P-450 CYP3A,1227,"As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.""?",False, -21820102,Ritonavir disrupts Coronavinae infectious disease,1228,"Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.","Is the triple ""Ritonavir disrupts Coronavinae infectious disease"" supported by the sentence: ""Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.""?",False, -15656958,Ritonavir disrupts HIV infectious disease,1229,Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.,"Is the triple ""Ritonavir disrupts HIV infectious disease"" supported by the sentence: ""Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.""?",False, -9520113,Ritonavir disrupts neoplasm,1230,"In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.","Is the triple ""Ritonavir disrupts neoplasm"" supported by the sentence: ""In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.""?",False, -22737012,Ritonavir prevents neoplasm,1231,"Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.","Is the triple ""Ritonavir prevents neoplasm"" supported by the sentence: ""Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.""?",False, -10934319,Ritonavir prevents Kaposi's sarcoma,1232,The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.,"Is the triple ""Ritonavir prevents Kaposi's sarcoma"" supported by the sentence: ""The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.""?",False, -12915909,Nelfinavir causes diarrheal disease,1233,Does Roche's nelfinavir cause less diarrhea?,"Is the triple ""Nelfinavir causes diarrheal disease"" supported by the sentence: ""Does Roche's nelfinavir cause less diarrhea?""?",False, -19184628,Nelfinavir affects neoplasm,1234,"Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.","Is the triple ""Nelfinavir affects neoplasm"" supported by the sentence: ""Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.""?",False, -16087478,Nelfinavir affects plasma cell myeloma,1235,We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.,"Is the triple ""Nelfinavir affects plasma cell myeloma"" supported by the sentence: ""We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.""?",False, -11272488,Nelfinavir affects diarrheal disease,1236,"The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.","Is the triple ""Nelfinavir affects diarrheal disease"" supported by the sentence: ""The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.""?",False, -10940786,Thiopental affects brain injury,1237,"Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.","Is the triple ""Thiopental affects brain injury"" supported by the sentence: ""Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.""?",False, -7790675,Thiopental prevents brain injury,1238,"BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.","Is the triple ""Thiopental prevents brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.""?",False, -26262897,Pentobarbital causes insomnia,1239,The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.,"Is the triple ""Pentobarbital causes insomnia"" supported by the sentence: ""The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.""?",False, -25778415,Pentobarbital affects insomnia,1240,"Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""","Is the triple ""Pentobarbital affects insomnia"" supported by the sentence: ""Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""""?",False, -13642757,Pentobarbital disrupts status epilepticus,1241,"The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.","Is the triple ""Pentobarbital disrupts status epilepticus"" supported by the sentence: ""The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.""?",False, -23761012,Amobarbital prevents osteoarthritis,1242,"A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).","Is the triple ""Amobarbital prevents osteoarthritis"" supported by the sentence: ""A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).""?",False, -26983984,Moxisylyte causes erectile dysfunction,1243,"Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.","Is the triple ""Moxisylyte causes erectile dysfunction"" supported by the sentence: ""Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.""?",False, -26385811,Mepyramine prevents allergic disease,1244,Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).,"Is the triple ""Mepyramine prevents allergic disease"" supported by the sentence: ""Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).""?",False, -27140633,Promethazine subclass of Promethazine sulfoxide,1245,Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.,"Is the triple ""Promethazine subclass of Promethazine sulfoxide"" supported by the sentence: ""Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.""?",False, -19124534,Promethazine related to Vomiting,1246,"A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.","Is the triple ""Promethazine related to Vomiting"" supported by the sentence: ""A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.""?",False, -26252918,Promethazine causes Vomiting,1247,"Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.","Is the triple ""Promethazine causes Vomiting"" supported by the sentence: ""Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.""?",False, -8157500,Promethazine causes depressive disorder,1248,Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.,"Is the triple ""Promethazine causes depressive disorder"" supported by the sentence: ""Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.""?",False, -19547748,Promethazine affects Vomiting,1249,"The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).""?",False, -12404928,Promethazine affects Pruritus,1250,"Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.","Is the triple ""Promethazine affects Pruritus"" supported by the sentence: ""Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.""?",False, -10742218,Promethazine affects Nausea,1251,The effect of promethazine in nausea and vomiting of pregnancy.,"Is the triple ""Promethazine affects Nausea"" supported by the sentence: ""The effect of promethazine in nausea and vomiting of pregnancy.""?",False, -10228295,Promethazine affects central nervous system origin vertigo,1252,"We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.","Is the triple ""Promethazine affects central nervous system origin vertigo"" supported by the sentence: ""We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.""?",False, -7912966,Promethazine affects Vomiting,1253,"STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.""?",False, -13616931,Promethazine disrupts Nausea,1254,"Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).","Is the triple ""Promethazine disrupts Nausea"" supported by the sentence: ""Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).""?",False, -17497020,Promethazine prevents central nervous system origin vertigo,1255,OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.,"Is the triple ""Promethazine prevents central nervous system origin vertigo"" supported by the sentence: ""OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.""?",False, -11541778,Promethazine prevents Pruritus,1256,RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.,"Is the triple ""Promethazine prevents Pruritus"" supported by the sentence: ""RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.""?",False, -7912965,Promethazine prevents Vomiting,1257,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Vomiting"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, -7912964,Promethazine prevents Nausea,1258,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Nausea"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, -25750000,Clemastine causes urticaria,1259,"The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.","Is the triple ""Clemastine causes urticaria"" supported by the sentence: ""The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.""?",False, -25747466,Clemastine affects urticaria,1260,"The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.","Is the triple ""Clemastine affects urticaria"" supported by the sentence: ""The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.""?",False, -19433677,Clemastine affects Pruritus,1261,"The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.","Is the triple ""Clemastine affects Pruritus"" supported by the sentence: ""The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.""?",False, -25634655,Clemastine disrupts urticaria,1262,"Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.","Is the triple ""Clemastine disrupts urticaria"" supported by the sentence: ""Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.""?",False, -24612586,Clemastine prevents urticaria,1263,"An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.","Is the triple ""Clemastine prevents urticaria"" supported by the sentence: ""An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.""?",False, -17916924,Clemastine prevents dermatitis,1264,"The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.","Is the triple ""Clemastine prevents dermatitis"" supported by the sentence: ""The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.""?",False, -24699384,Clemastine predisposes allergic disease,1265,"To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.","Is the triple ""Clemastine predisposes allergic disease"" supported by the sentence: ""To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.""?",False, -25081855,Tiapride affects Dopamine D2 Receptor,1266,"Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.","Is the triple ""Tiapride affects Dopamine D2 Receptor"" supported by the sentence: ""Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.""?",False, -19553406,Amisulpride causes schizophrenia,1267,rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.,"Is the triple ""Amisulpride causes schizophrenia"" supported by the sentence: ""rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.""?",False, -9337142,Amisulpride causes psychotic disorder,1268,"Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.","Is the triple ""Amisulpride causes psychotic disorder"" supported by the sentence: ""Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.""?",False, -24415555,Amisulpride affects depressive disorder,1269,"The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.","Is the triple ""Amisulpride affects depressive disorder"" supported by the sentence: ""The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.""?",False, -8493076,Amisulpride affects schizophrenia,1270,"In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.","Is the triple ""Amisulpride affects schizophrenia"" supported by the sentence: ""In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.""?",False, -20532376,Amisulpride prevents Postoperative Nausea and Vomiting,1271,"Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.","Is the triple ""Amisulpride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.""?",False, -19821343,Amisulpride prevents Nausea,1272,Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.,"Is the triple ""Amisulpride prevents Nausea"" supported by the sentence: ""Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.""?",False, -11149280,Remoxipride physically interacts with Dopamine D2 Receptor,1273,Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.,"Is the triple ""Remoxipride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.""?",False, -9174370,Remoxipride affects Dopamine D2 Receptor,1274,Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.,"Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.""?",False, -24158881,Remoxipride affects Dopamine D2 Receptor,1275,"Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.","Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.""?",False, -20394421,Levosulpiride affects Dopamine D2 Receptor,1276,"Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.","Is the triple ""Levosulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.""?",False, -26880772,Nitroglycerin related to coronary artery disorder,1277,Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.,"Is the triple ""Nitroglycerin related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.""?",False, -26139329,Nitroglycerin related to hypertensive disorder,1278,A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.,"Is the triple ""Nitroglycerin related to hypertensive disorder"" supported by the sentence: ""A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.""?",False, -21173297,Nitroglycerin related to injury,1279,"Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.","Is the triple ""Nitroglycerin related to injury"" supported by the sentence: ""Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.""?",False, -26585664,Nitroglycerin causes Raynaud disease,1280,Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.,"Is the triple ""Nitroglycerin causes Raynaud disease"" supported by the sentence: ""Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.""?",False, -26278376,Nitroglycerin causes Angina pectoris,1281,Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.,"Is the triple ""Nitroglycerin causes Angina pectoris"" supported by the sentence: ""Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.""?",False, -26148974,Nitroglycerin causes myocardial infarction,1282,Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.,"Is the triple ""Nitroglycerin causes myocardial infarction"" supported by the sentence: ""Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.""?",False, -15949436,Nitroglycerin causes injury,1283,"If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.","Is the triple ""Nitroglycerin causes injury"" supported by the sentence: ""If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.""?",False, -15624022,Nitroglycerin causes Inflammation,1284,Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.,"Is the triple ""Nitroglycerin causes Inflammation"" supported by the sentence: ""Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.""?",False, -14985558,Nitroglycerin causes hypertensive disorder,1285,STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.,"Is the triple ""Nitroglycerin causes hypertensive disorder"" supported by the sentence: ""STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.""?",False, -8402702,Nitroglycerin causes Pain,1286,Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.,"Is the triple ""Nitroglycerin causes Pain"" supported by the sentence: ""Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.""?",False, -7629693,Nitroglycerin causes hypotensive disorder,1287,"In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.","Is the triple ""Nitroglycerin causes hypotensive disorder"" supported by the sentence: ""In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.""?",False, -26786108,Nitroglycerin affects coronary artery disorder,1288,Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.""?",False, -26278652,Nitroglycerin affects hypotensive disorder,1289,"This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.","Is the triple ""Nitroglycerin affects hypotensive disorder"" supported by the sentence: ""This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.""?",False, -25994904,Nitroglycerin affects Raynaud disease,1290,"The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.","Is the triple ""Nitroglycerin affects Raynaud disease"" supported by the sentence: ""The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.""?",False, -25747829,Nitroglycerin affects erectile dysfunction,1291,Impotence responsive to glyceryl trinitrate.,"Is the triple ""Nitroglycerin affects erectile dysfunction"" supported by the sentence: ""Impotence responsive to glyceryl trinitrate.""?",False, -25260538,Nitroglycerin affects Muscle spasm,1292,Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.,"Is the triple ""Nitroglycerin affects Muscle spasm"" supported by the sentence: ""Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.""?",False, -23178151,Nitroglycerin affects coronary artery disorder,1293,Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.""?",False, -20885558,Nitroglycerin affects injury,1294,Cardiac output effects of nitroglycerin in experimental lung injury.,"Is the triple ""Nitroglycerin affects injury"" supported by the sentence: ""Cardiac output effects of nitroglycerin in experimental lung injury.""?",False, -18491008,Nitroglycerin affects Hot flashes,1295,"After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).","Is the triple ""Nitroglycerin affects Hot flashes"" supported by the sentence: ""After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).""?",False, -14421188,Nitroglycerin affects Angina pectoris,1296,"Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).","Is the triple ""Nitroglycerin affects Angina pectoris"" supported by the sentence: ""Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).""?",False, -13478654,Nitroglycerin affects osteoporosis,1297,The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.,"Is the triple ""Nitroglycerin affects osteoporosis"" supported by the sentence: ""The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.""?",False, -11707783,Nitroglycerin affects Pain,1298,"We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.","Is the triple ""Nitroglycerin affects Pain"" supported by the sentence: ""We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.""?",False, -11174035,Nitroglycerin affects hypertensive disorder,1299,"The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.","Is the triple ""Nitroglycerin affects hypertensive disorder"" supported by the sentence: ""The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.""?",False, -10595566,Nitroglycerin affects stroke disorder,1300,[On the effect of nitroglycerin on the stroke- and minute volume of the heart].,"Is the triple ""Nitroglycerin affects stroke disorder"" supported by the sentence: ""[On the effect of nitroglycerin on the stroke- and minute volume of the heart].""?",False, -8601510,Nitroglycerin affects myocardial ischemia,1301,Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.,"Is the triple ""Nitroglycerin affects myocardial ischemia"" supported by the sentence: ""Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.""?",False, -8521770,Nitroglycerin affects phlebitis,1302,Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.,"Is the triple ""Nitroglycerin affects phlebitis"" supported by the sentence: ""Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.""?",False, -8049127,Nitroglycerin affects ischemia reperfusion injury,1303,Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.,"Is the triple ""Nitroglycerin affects ischemia reperfusion injury"" supported by the sentence: ""Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.""?",False, -26813951,Nitroglycerin disrupts myocardial ischemia,1304,Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.,"Is the triple ""Nitroglycerin disrupts myocardial ischemia"" supported by the sentence: ""Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.""?",False, -26590847,Nitroglycerin disrupts hypertensive disorder,1305,"CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.","Is the triple ""Nitroglycerin disrupts hypertensive disorder"" supported by the sentence: ""CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.""?",False, -24386334,Nitroglycerin disrupts phlebitis,1306,"The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).","Is the triple ""Nitroglycerin disrupts phlebitis"" supported by the sentence: ""The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).""?",False, -19274234,Nitroglycerin disrupts injury,1307,"Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.","Is the triple ""Nitroglycerin disrupts injury"" supported by the sentence: ""Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.""?",False, -10081147,Nitroglycerin disrupts Marchiafava-Bignami disease,1308,These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.,"Is the triple ""Nitroglycerin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.""?",False, -9796564,Nitroglycerin disrupts Pain,1309,At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.,"Is the triple ""Nitroglycerin disrupts Pain"" supported by the sentence: ""At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.""?",False, -25569906,Nitroglycerin prevents phlebitis,1310,CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.,"Is the triple ""Nitroglycerin prevents phlebitis"" supported by the sentence: ""CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.""?",False, -21983895,Nitroglycerin prevents Muscle spasm,1311,Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.,"Is the triple ""Nitroglycerin prevents Muscle spasm"" supported by the sentence: ""Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.""?",False, -20473117,Nitroglycerin prevents Inflammation,1312,Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.,"Is the triple ""Nitroglycerin prevents Inflammation"" supported by the sentence: ""Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.""?",False, -18491009,Nitroglycerin prevents Hot flashes,1313,CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.,"Is the triple ""Nitroglycerin prevents Hot flashes"" supported by the sentence: ""CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.""?",False, -17804368,Nitroglycerin prevents hypertensive disorder,1314,"Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.","Is the triple ""Nitroglycerin prevents hypertensive disorder"" supported by the sentence: ""Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.""?",False, -11496690,Nitroglycerin prevents ischemia reperfusion injury,1315,CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.,"Is the triple ""Nitroglycerin prevents ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.""?",False, -10695579,Nitroglycerin prevents Angina pectoris,1316,A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.,"Is the triple ""Nitroglycerin prevents Angina pectoris"" supported by the sentence: ""A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.""?",False, -10573276,Nitroglycerin prevents myocardial infarction,1317,Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.,"Is the triple ""Nitroglycerin prevents myocardial infarction"" supported by the sentence: ""Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.""?",False, -9096899,Nitroglycerin prevents Pain,1318,Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.,"Is the triple ""Nitroglycerin prevents Pain"" supported by the sentence: ""Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.""?",False, -9057729,Nitroglycerin prevents Shock,1319,"Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).","Is the triple ""Nitroglycerin prevents Shock"" supported by the sentence: ""Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).""?",False, -8235862,Nitroglycerin prevents Marchiafava-Bignami disease,1320,"Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).","Is the triple ""Nitroglycerin prevents Marchiafava-Bignami disease"" supported by the sentence: ""Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).""?",False, -7713034,Nitroglycerin prevents injury,1321,"It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.","Is the triple ""Nitroglycerin prevents injury"" supported by the sentence: ""It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.""?",False, -13750741,Nitroglycerin exacerbates myocardial ischemia,1322,"RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).","Is the triple ""Nitroglycerin exacerbates myocardial ischemia"" supported by the sentence: ""RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).""?",False, -20483551,Nitroglycerin predisposes myocardial ischemia,1323,OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.,"Is the triple ""Nitroglycerin predisposes myocardial ischemia"" supported by the sentence: ""OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.""?",False, -9897513,Nitroglycerin predisposes Angina pectoris,1324,Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.,"Is the triple ""Nitroglycerin predisposes Angina pectoris"" supported by the sentence: ""Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.""?",False, -20924645,Isosorbide dinitrate related to myocardial ischemia,1325,Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.,"Is the triple ""Isosorbide dinitrate related to myocardial ischemia"" supported by the sentence: ""Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.""?",False, -10616906,Isosorbide dinitrate related to Angina pectoris,1326,Isosorbide dinitrate in angina pectoris.,"Is the triple ""Isosorbide dinitrate related to Angina pectoris"" supported by the sentence: ""Isosorbide dinitrate in angina pectoris.""?",False, -9112334,Isosorbide dinitrate related to coronary artery disorder,1327,Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.,"Is the triple ""Isosorbide dinitrate related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.""?",False, -26334868,Isosorbide dinitrate affects Angina pectoris,1328,The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.,"Is the triple ""Isosorbide dinitrate affects Angina pectoris"" supported by the sentence: ""The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.""?",False, -10884689,Isosorbide dinitrate affects myocardial ischemia,1329,The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.,"Is the triple ""Isosorbide dinitrate affects myocardial ischemia"" supported by the sentence: ""The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.""?",False, -9112335,Isosorbide dinitrate prevents myocardial ischemia,1330,"To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.","Is the triple ""Isosorbide dinitrate prevents myocardial ischemia"" supported by the sentence: ""To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.""?",False, -17782283,Sulpiride physically interacts with Dopamine D2 Receptor,1331,"The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.""?",False, -7084056,Sulpiride physically interacts with Dopamine D2 Receptor,1332,"Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.""?",False, -25690684,Sulpiride causes depressive disorder,1333,"Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.","Is the triple ""Sulpiride causes depressive disorder"" supported by the sentence: ""Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.""?",False, -26343015,Sulpiride affects schizophrenia,1334,"On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.","Is the triple ""Sulpiride affects schizophrenia"" supported by the sentence: ""On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.""?",False, -23882267,Sulpiride affects anxiety,1335,Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.,"Is the triple ""Sulpiride affects anxiety"" supported by the sentence: ""Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.""?",False, -8960439,Sulpiride affects depressive disorder,1336,"This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.""?",False, -8364166,Sulpiride affects Dopamine D2 Receptor,1337,"Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.","Is the triple ""Sulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.""?",False, -7538297,Sulpiride affects depressive disorder,1338,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, -25756981,Sulpiride disrupts depressive disorder,1339,"(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.","Is the triple ""Sulpiride disrupts depressive disorder"" supported by the sentence: ""(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.""?",False, -8859505,Sulpiride disrupts anxiety,1340,"Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.","Is the triple ""Sulpiride disrupts anxiety"" supported by the sentence: ""Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.""?",False, -26753868,Isosorbide mononitrate causes Angina pectoris,1341,"To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.","Is the triple ""Isosorbide mononitrate causes Angina pectoris"" supported by the sentence: ""To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.""?",False, -15856723,Isosorbide mononitrate affects Angina pectoris,1342,Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.,"Is the triple ""Isosorbide mononitrate affects Angina pectoris"" supported by the sentence: ""Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.""?",False, -24979081,Isosorbide mononitrate prevents vascular disorder,1343,METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.,"Is the triple ""Isosorbide mononitrate prevents vascular disorder"" supported by the sentence: ""METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.""?",False, -22319748,Isosorbide mononitrate prevents Angina pectoris,1344,"Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.","Is the triple ""Isosorbide mononitrate prevents Angina pectoris"" supported by the sentence: ""Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.""?",False, -23203614,Ribociclib related to squamous cell carcinoma,1345,"Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.","Is the triple ""Ribociclib related to squamous cell carcinoma"" supported by the sentence: ""Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.""?",False, -23890460,Abemaciclib related to non-small cell lung carcinoma,1346,Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.,"Is the triple ""Abemaciclib related to non-small cell lung carcinoma"" supported by the sentence: ""Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.""?",False, -24133672,Abemaciclib affects neoplasm,1347,"We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.","Is the triple ""Abemaciclib affects neoplasm"" supported by the sentence: ""We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.""?",False, -23820208,Abemaciclib disrupts neoplasm,1348,Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.,"Is the triple ""Abemaciclib disrupts neoplasm"" supported by the sentence: ""Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.""?",False, -7114439,Sodium Chloride subclass of Electrolytes,1349,"LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.","Is the triple ""Sodium Chloride subclass of Electrolytes"" supported by the sentence: ""LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.""?",False, -27178225,Sodium Chloride related to hypoglycemia,1350,Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.,"Is the triple ""Sodium Chloride related to hypoglycemia"" supported by the sentence: ""Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.""?",False, -26906663,Sodium Chloride related to ventricular septal defect,1351,"When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).","Is the triple ""Sodium Chloride related to ventricular septal defect"" supported by the sentence: ""When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).""?",False, -26538206,Sodium Chloride related to papilloma,1352,The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.,"Is the triple ""Sodium Chloride related to papilloma"" supported by the sentence: ""The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.""?",False, -26529472,Sodium Chloride related to chronic obstructive pulmonary disease,1353,"Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.","Is the triple ""Sodium Chloride related to chronic obstructive pulmonary disease"" supported by the sentence: ""Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.""?",False, -26267091,Sodium Chloride related to Sepsis,1354,"The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.","Is the triple ""Sodium Chloride related to Sepsis"" supported by the sentence: ""The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.""?",False, -26209731,Sodium Chloride related to cataract,1355,Basic data supporting the use of the l-lysine salt of bendazac in cataract.,"Is the triple ""Sodium Chloride related to cataract"" supported by the sentence: ""Basic data supporting the use of the l-lysine salt of bendazac in cataract.""?",False, -25917183,Sodium Chloride related to Hypoxemia,1356,[Effect of vitamin C on water-salt metabolism in experimental hypoxia].,"Is the triple ""Sodium Chloride related to Hypoxemia"" supported by the sentence: ""[Effect of vitamin C on water-salt metabolism in experimental hypoxia].""?",False, -20673450,Sodium Chloride related to Alzheimer disease,1357,The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.,"Is the triple ""Sodium Chloride related to Alzheimer disease"" supported by the sentence: ""The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.""?",False, -20617514,Sodium Chloride related to type 2 diabetes mellitus,1358,"Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.","Is the triple ""Sodium Chloride related to type 2 diabetes mellitus"" supported by the sentence: ""Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.""?",False, -20321366,Sodium Chloride related to type 1 diabetes mellitus,1359,"In addition, NEN could impede the progression of DKD in T1D.","Is the triple ""Sodium Chloride related to type 1 diabetes mellitus"" supported by the sentence: ""In addition, NEN could impede the progression of DKD in T1D.""?",False, -19962817,Sodium Chloride related to Inflammation,1360,"These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.","Is the triple ""Sodium Chloride related to Inflammation"" supported by the sentence: ""These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.""?",False, -19891172,Sodium Chloride related to acute lung injury,1361,BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.,"Is the triple ""Sodium Chloride related to acute lung injury"" supported by the sentence: ""BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.""?",False, -19636264,Sodium Chloride related to ischemic disease,1362,"Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.","Is the triple ""Sodium Chloride related to ischemic disease"" supported by the sentence: ""Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.""?",False, -19577743,Sodium Chloride related to spinal cord injury,1363,OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.,"Is the triple ""Sodium Chloride related to spinal cord injury"" supported by the sentence: ""OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.""?",False, -19497082,Sodium Chloride related to primary ciliary dyskinesia,1364,A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.,"Is the triple ""Sodium Chloride related to primary ciliary dyskinesia"" supported by the sentence: ""A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.""?",False, -18975700,Sodium Chloride related to bacterial infectious disease,1365,Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.,"Is the triple ""Sodium Chloride related to bacterial infectious disease"" supported by the sentence: ""Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.""?",False, -18966398,Sodium Chloride related to osteoarthritis,1366,"CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.","Is the triple ""Sodium Chloride related to osteoarthritis"" supported by the sentence: ""CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.""?",False, -18860303,Sodium Chloride related to bone fracture,1367,Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).,"Is the triple ""Sodium Chloride related to bone fracture"" supported by the sentence: ""Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).""?",False, -18738706,Sodium Chloride related to toxic shock syndrome,1368,CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.,"Is the triple ""Sodium Chloride related to toxic shock syndrome"" supported by the sentence: ""CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.""?",False, -18679247,Sodium Chloride related to Electrolytes,1369,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, -18617363,Sodium Chloride related to iron deficiency anemia,1370,"At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.","Is the triple ""Sodium Chloride related to iron deficiency anemia"" supported by the sentence: ""At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.""?",False, -18287282,Sodium Chloride related to Pruritus,1371,"The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).","Is the triple ""Sodium Chloride related to Pruritus"" supported by the sentence: ""The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).""?",False, -17603340,Sodium Chloride related to brain injury,1372,Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.,"Is the triple ""Sodium Chloride related to brain injury"" supported by the sentence: ""Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.""?",False, -17533385,Sodium Chloride related to myocardial infarction,1373,Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.,"Is the triple ""Sodium Chloride related to myocardial infarction"" supported by the sentence: ""Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.""?",False, -17525035,Sodium Chloride related to coronary artery disorder,1374,The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.,"Is the triple ""Sodium Chloride related to coronary artery disorder"" supported by the sentence: ""The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.""?",False, -17213013,Sodium Chloride related to hepatocellular carcinoma,1375,"In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.","Is the triple ""Sodium Chloride related to hepatocellular carcinoma"" supported by the sentence: ""In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.""?",False, -17202845,Sodium Chloride related to Parkinson disease,1376,These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.,"Is the triple ""Sodium Chloride related to Parkinson disease"" supported by the sentence: ""These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.""?",False, -16886803,Sodium Chloride related to ischemia reperfusion injury,1377,Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.,"Is the triple ""Sodium Chloride related to ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.""?",False, -16594665,Sodium Chloride related to Pain,1378,"In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.","Is the triple ""Sodium Chloride related to Pain"" supported by the sentence: ""In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.""?",False, -16433967,Sodium Chloride related to liver and intrahepatic bile duct neoplasm,1379,Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.,"Is the triple ""Sodium Chloride related to liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.""?",False, -15412515,Sodium Chloride related to subarachnoid hemorrhage,1380,Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).,"Is the triple ""Sodium Chloride related to subarachnoid hemorrhage"" supported by the sentence: ""Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).""?",False, -14710472,Sodium Chloride related to bronchiolitis,1381,"High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.","Is the triple ""Sodium Chloride related to bronchiolitis"" supported by the sentence: ""High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.""?",False, -14037713,Sodium Chloride related to ventricular tachycardia,1382,"Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.","Is the triple ""Sodium Chloride related to ventricular tachycardia"" supported by the sentence: ""Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.""?",False, -13928740,Sodium Chloride related to pulmonary edema,1383,"Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.","Is the triple ""Sodium Chloride related to pulmonary edema"" supported by the sentence: ""Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.""?",False, -13375642,Sodium Chloride related to Insulin resistance,1384,"CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.","Is the triple ""Sodium Chloride related to Insulin resistance"" supported by the sentence: ""CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.""?",False, -13343201,Sodium Chloride related to Hypernatremia,1385,CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.,"Is the triple ""Sodium Chloride related to Hypernatremia"" supported by the sentence: ""CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.""?",False, -13277977,Sodium Chloride related to diabetic ketoacidosis,1386,The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.,"Is the triple ""Sodium Chloride related to diabetic ketoacidosis"" supported by the sentence: ""The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.""?",False, -11905993,Sodium Chloride related to depressive disorder,1387,"This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.","Is the triple ""Sodium Chloride related to depressive disorder"" supported by the sentence: ""This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.""?",False, -11014479,Sodium Chloride related to glaucoma,1388,[Dynamics of sodium chloride in the blood in glaucoma].,"Is the triple ""Sodium Chloride related to glaucoma"" supported by the sentence: ""[Dynamics of sodium chloride in the blood in glaucoma].""?",False, -10966302,Sodium Chloride related to malaria,1389,"Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.","Is the triple ""Sodium Chloride related to malaria"" supported by the sentence: ""Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.""?",False, -10739226,Sodium Chloride related to heart disorder,1390,[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].,"Is the triple ""Sodium Chloride related to heart disorder"" supported by the sentence: ""[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].""?",False, -10689901,Sodium Chloride related to diabetes mellitus,1391,[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].,"Is the triple ""Sodium Chloride related to diabetes mellitus"" supported by the sentence: ""[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].""?",False, -10566407,Sodium Chloride related to brain cancer,1392,[Water-salt and carbohydrate metabolism in brain tumors].,"Is the triple ""Sodium Chloride related to brain cancer"" supported by the sentence: ""[Water-salt and carbohydrate metabolism in brain tumors].""?",False, -10531148,Sodium Chloride related to kidney failure,1393,"[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].","Is the triple ""Sodium Chloride related to kidney failure"" supported by the sentence: ""[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].""?",False, -10510273,Sodium Chloride related to Shock,1394,[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].,"Is the triple ""Sodium Chloride related to Shock"" supported by the sentence: ""[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].""?",False, -10504585,Sodium Chloride related to tuberculosis,1395,[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].,"Is the triple ""Sodium Chloride related to tuberculosis"" supported by the sentence: ""[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].""?",False, -10502982,Sodium Chloride related to nutritional disorder,1396,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to nutritional disorder"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, -10502981,Sodium Chloride related to cirrhosis of liver,1397,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to cirrhosis of liver"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, -10487095,Sodium Chloride related to pneumonia,1398,[Water and salt content in the lung in vagus pneumonia].,"Is the triple ""Sodium Chloride related to pneumonia"" supported by the sentence: ""[Water and salt content in the lung in vagus pneumonia].""?",False, -10439781,Sodium Chloride related to acute kidney failure,1399,Patterns of renal salt loss in acute renal failure.,"Is the triple ""Sodium Chloride related to acute kidney failure"" supported by the sentence: ""Patterns of renal salt loss in acute renal failure.""?",False, -10433628,Sodium Chloride related to psoriasis,1400,[Studies on water and salt metabolism in psoriasis].,"Is the triple ""Sodium Chloride related to psoriasis"" supported by the sentence: ""[Studies on water and salt metabolism in psoriasis].""?",False, -10370762,Sodium Chloride related to Hypothermia,1401,[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].,"Is the triple ""Sodium Chloride related to Hypothermia"" supported by the sentence: ""[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].""?",False, -10318383,Sodium Chloride related to cardiovascular disorder,1402,Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.,"Is the triple ""Sodium Chloride related to cardiovascular disorder"" supported by the sentence: ""Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.""?",False, -10300324,Sodium Chloride related to stroke disorder,1403,"Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).","Is the triple ""Sodium Chloride related to stroke disorder"" supported by the sentence: ""Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).""?",False, -10268953,Sodium Chloride related to brain edema,1404,"The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.","Is the triple ""Sodium Chloride related to brain edema"" supported by the sentence: ""The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.""?",False, -9985623,Sodium Chloride related to Nausea,1405,"Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.","Is the triple ""Sodium Chloride related to Nausea"" supported by the sentence: ""Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.""?",False, -9642141,Sodium Chloride related to obesity disorder,1406,"The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).","Is the triple ""Sodium Chloride related to obesity disorder"" supported by the sentence: ""The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).""?",False, -9504754,Sodium Chloride related to asthma,1407,Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.,"Is the triple ""Sodium Chloride related to asthma"" supported by the sentence: ""Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.""?",False, -9350794,Sodium Chloride related to essential hypertension,1408,[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].,"Is the triple ""Sodium Chloride related to essential hypertension"" supported by the sentence: ""[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].""?",False, -9217528,Sodium Chloride related to dry eye syndrome,1409,The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.,"Is the triple ""Sodium Chloride related to dry eye syndrome"" supported by the sentence: ""The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.""?",False, -8489872,Sodium Chloride related to injury,1410,Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.,"Is the triple ""Sodium Chloride related to injury"" supported by the sentence: ""Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.""?",False, -8486278,Sodium Chloride related to cystic fibrosis,1411,"We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.","Is the triple ""Sodium Chloride related to cystic fibrosis"" supported by the sentence: ""We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.""?",False, -7822303,Sodium Chloride related to neoplasm,1412,"Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.","Is the triple ""Sodium Chloride related to neoplasm"" supported by the sentence: ""Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.""?",False, -7455347,Sodium Chloride related to Hypovolemia,1413,"It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.","Is the triple ""Sodium Chloride related to Hypovolemia"" supported by the sentence: ""It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.""?",False, -7397406,Sodium Chloride related to kidney disorder,1414,Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.,"Is the triple ""Sodium Chloride related to kidney disorder"" supported by the sentence: ""Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.""?",False, -7259411,Sodium Chloride related to hypertensive disorder,1415,"Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.","Is the triple ""Sodium Chloride related to hypertensive disorder"" supported by the sentence: ""Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.""?",False, -19769676,Sodium Chloride related to Electrolytes,1416,"Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.","Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.""?",False, -18679248,Sodium Chloride close match Electrolytes,1417,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride close match Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, -7792933,Sodium Chloride coexists with Electrolytes,1418,"Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).","Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).""?",False, -9181325,Sodium Chloride coexists with Electrolytes,1419,Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.,"Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.""?",False, -27223278,Sodium Chloride derives from Electrolytes,1420,The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.,"Is the triple ""Sodium Chloride derives from Electrolytes"" supported by the sentence: ""The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.""?",False, -9585905,Sodium Chloride physically interacts with Electrolytes,1421,"The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.""?",False, -9585904,Sodium Chloride physically interacts with Electrolytes,1422,"The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.""?",False, -26947391,Sodium Chloride causes acute kidney tubular necrosis,1423,"Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).","Is the triple ""Sodium Chloride causes acute kidney tubular necrosis"" supported by the sentence: ""Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).""?",False, -26813055,Sodium Chloride causes Dyspnea,1424,"When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.","Is the triple ""Sodium Chloride causes Dyspnea"" supported by the sentence: ""When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.""?",False, -26651944,Sodium Chloride causes severe cutaneous adverse reaction,1425,In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.,"Is the triple ""Sodium Chloride causes severe cutaneous adverse reaction"" supported by the sentence: ""In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.""?",False, -26200221,Sodium Chloride causes melanoma,1426,In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.,"Is the triple ""Sodium Chloride causes melanoma"" supported by the sentence: ""In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.""?",False, -25963723,Sodium Chloride causes cardiac arrest,1427,Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.,"Is the triple ""Sodium Chloride causes cardiac arrest"" supported by the sentence: ""Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.""?",False, -24999522,Sodium Chloride causes Nausea,1428,"In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.","Is the triple ""Sodium Chloride causes Nausea"" supported by the sentence: ""In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.""?",False, -23507574,Sodium Chloride causes burn,1429,"The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.","Is the triple ""Sodium Chloride causes burn"" supported by the sentence: ""The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.""?",False, -21365055,Sodium Chloride causes respiratory failure,1430,Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.,"Is the triple ""Sodium Chloride causes respiratory failure"" supported by the sentence: ""Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.""?",False, -20716492,Sodium Chloride causes multiple organ dysfunction syndrome,1431,"Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.","Is the triple ""Sodium Chloride causes multiple organ dysfunction syndrome"" supported by the sentence: ""Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.""?",False, -20666627,Sodium Chloride causes malaria,1432,"During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.","Is the triple ""Sodium Chloride causes malaria"" supported by the sentence: ""During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.""?",False, -20168868,Sodium Chloride causes fibromyalgia,1433,"Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.","Is the triple ""Sodium Chloride causes fibromyalgia"" supported by the sentence: ""Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.""?",False, -19652731,Sodium Chloride causes Chronic pain,1434,"METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.","Is the triple ""Sodium Chloride causes Chronic pain"" supported by the sentence: ""METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.""?",False, -19581650,Sodium Chloride causes neoplasm,1435,"NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.","Is the triple ""Sodium Chloride causes neoplasm"" supported by the sentence: ""NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.""?",False, -19527177,Sodium Chloride causes liver and intrahepatic bile duct neoplasm,1436,"Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.","Is the triple ""Sodium Chloride causes liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.""?",False, -19434783,Sodium Chloride causes Low back pain,1437,"METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).","Is the triple ""Sodium Chloride causes Low back pain"" supported by the sentence: ""METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).""?",False, -19352698,Sodium Chloride causes bone fracture,1438,"Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.","Is the triple ""Sodium Chloride causes bone fracture"" supported by the sentence: ""Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.""?",False, -19268574,Sodium Chloride causes ulcerative colitis,1439,"Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.","Is the triple ""Sodium Chloride causes ulcerative colitis"" supported by the sentence: ""Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.""?",False, -18873789,Sodium Chloride causes preeclampsia,1440,This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.,"Is the triple ""Sodium Chloride causes preeclampsia"" supported by the sentence: ""This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.""?",False, -18760766,Sodium Chloride causes heart disorder,1441,"Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.","Is the triple ""Sodium Chloride causes heart disorder"" supported by the sentence: ""Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.""?",False, -18419412,Sodium Chloride causes infertility disorder,1442,"The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.","Is the triple ""Sodium Chloride causes infertility disorder"" supported by the sentence: ""The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.""?",False, -18184755,Sodium Chloride causes intervertebral disc degenerative disorder,1443,"Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.","Is the triple ""Sodium Chloride causes intervertebral disc degenerative disorder"" supported by the sentence: ""Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.""?",False, -18174270,Sodium Chloride causes asthma,1444,"We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.","Is the triple ""Sodium Chloride causes asthma"" supported by the sentence: ""We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.""?",False, -17957169,Sodium Chloride causes subarachnoid hemorrhage,1445,Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.,"Is the triple ""Sodium Chloride causes subarachnoid hemorrhage"" supported by the sentence: ""Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.""?",False, -17846702,Sodium Chloride causes cardiovascular disorder,1446,"Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.","Is the triple ""Sodium Chloride causes cardiovascular disorder"" supported by the sentence: ""Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.""?",False, -17472790,Sodium Chloride causes Postoperative Complications,1447,"BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.","Is the triple ""Sodium Chloride causes Postoperative Complications"" supported by the sentence: ""BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.""?",False, -17050802,Sodium Chloride causes pulmonary arterial hypertension,1448,Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.,"Is the triple ""Sodium Chloride causes pulmonary arterial hypertension"" supported by the sentence: ""Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.""?",False, -16922792,Sodium Chloride causes aortic aneurysm,1449,"CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.","Is the triple ""Sodium Chloride causes aortic aneurysm"" supported by the sentence: ""CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.""?",False, -16902385,Sodium Chloride causes Hypoxemia,1450,The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.,"Is the triple ""Sodium Chloride causes Hypoxemia"" supported by the sentence: ""The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.""?",False, -16884655,Sodium Chloride causes obesity disorder,1451,[Promoting obesity with the salt shaker. How too much salt causes obesity in children].,"Is the triple ""Sodium Chloride causes obesity disorder"" supported by the sentence: ""[Promoting obesity with the salt shaker. How too much salt causes obesity in children].""?",False, -15862216,Sodium Chloride causes Sepsis,1452,"In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.","Is the triple ""Sodium Chloride causes Sepsis"" supported by the sentence: ""In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.""?",False, -15183436,Sodium Chloride causes cardiac rhythm disease,1453,"CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""","Is the triple ""Sodium Chloride causes cardiac rhythm disease"" supported by the sentence: ""CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""""?",False, -14507617,Sodium Chloride causes brain edema,1454,"The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.","Is the triple ""Sodium Chloride causes brain edema"" supported by the sentence: ""The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.""?",False, -14335740,Sodium Chloride causes essential hypertension,1455,"Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.","Is the triple ""Sodium Chloride causes essential hypertension"" supported by the sentence: ""Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.""?",False, -14100671,Sodium Chloride causes Cough,1456,"Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.","Is the triple ""Sodium Chloride causes Cough"" supported by the sentence: ""Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.""?",False, -13899816,Sodium Chloride causes brain injury,1457,BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.,"Is the triple ""Sodium Chloride causes brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.""?",False, -13415978,Sodium Chloride causes rhinitis,1458,Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).,"Is the triple ""Sodium Chloride causes rhinitis"" supported by the sentence: ""Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).""?",False, -13156241,Sodium Chloride causes allergic disease,1459,"The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.","Is the triple ""Sodium Chloride causes allergic disease"" supported by the sentence: ""The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.""?",False, -12922926,Sodium Chloride causes periodontitis,1460,"Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.","Is the triple ""Sodium Chloride causes periodontitis"" supported by the sentence: ""Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.""?",False, -12796728,Sodium Chloride causes myocardial infarction,1461,"Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.","Is the triple ""Sodium Chloride causes myocardial infarction"" supported by the sentence: ""Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.""?",False, -12757253,Sodium Chloride causes urticaria,1462,"If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.","Is the triple ""Sodium Chloride causes urticaria"" supported by the sentence: ""If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.""?",False, -12052924,Sodium Chloride causes Fever,1463,"Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.","Is the triple ""Sodium Chloride causes Fever"" supported by the sentence: ""Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.""?",False, -11367442,Sodium Chloride causes Hypothermia,1464,"In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.","Is the triple ""Sodium Chloride causes Hypothermia"" supported by the sentence: ""In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.""?",False, -10844905,Sodium Chloride causes kidney disorder,1465,These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.,"Is the triple ""Sodium Chloride causes kidney disorder"" supported by the sentence: ""These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.""?",False, -10703852,Sodium Chloride causes Ascites,1466,Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.,"Is the triple ""Sodium Chloride causes Ascites"" supported by the sentence: ""Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.""?",False, -10680402,Sodium Chloride causes kidney failure,1467,[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].,"Is the triple ""Sodium Chloride causes kidney failure"" supported by the sentence: ""[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].""?",False, -10468869,Sodium Chloride causes Hyperhidrosis,1468,The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.,"Is the triple ""Sodium Chloride causes Hyperhidrosis"" supported by the sentence: ""The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.""?",False, -10303736,Sodium Chloride causes Hemorrhage,1469,Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.,"Is the triple ""Sodium Chloride causes Hemorrhage"" supported by the sentence: ""Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.""?",False, -10216492,Sodium Chloride causes Insulin resistance,1470,"What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.","Is the triple ""Sodium Chloride causes Insulin resistance"" supported by the sentence: ""What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.""?",False, -9649854,Sodium Chloride causes Inflammation,1471,Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.,"Is the triple ""Sodium Chloride causes Inflammation"" supported by the sentence: ""Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.""?",False, -9417058,Sodium Chloride causes stroke disorder,1472,"The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.","Is the triple ""Sodium Chloride causes stroke disorder"" supported by the sentence: ""The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.""?",False, -9370401,Sodium Chloride causes acute kidney failure,1473,"RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.","Is the triple ""Sodium Chloride causes acute kidney failure"" supported by the sentence: ""RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.""?",False, -9311776,Sodium Chloride causes hypotensive disorder,1474,Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.,"Is the triple ""Sodium Chloride causes hypotensive disorder"" supported by the sentence: ""Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.""?",False, -8912328,Sodium Chloride causes injury,1475,"Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.","Is the triple ""Sodium Chloride causes injury"" supported by the sentence: ""Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.""?",False, -8760965,Sodium Chloride causes hyperinsulinism,1476,"Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).","Is the triple ""Sodium Chloride causes hyperinsulinism"" supported by the sentence: ""Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).""?",False, -8723767,Sodium Chloride causes Hyponatremia,1477,"The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.","Is the triple ""Sodium Chloride causes Hyponatremia"" supported by the sentence: ""The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.""?",False, -8658207,Sodium Chloride causes ischemic disease,1478,"Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.","Is the triple ""Sodium Chloride causes ischemic disease"" supported by the sentence: ""Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.""?",False, -8215909,Sodium Chloride causes type 2 diabetes mellitus,1479,"The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.","Is the triple ""Sodium Chloride causes type 2 diabetes mellitus"" supported by the sentence: ""The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.""?",False, -7966995,Sodium Chloride causes Shock,1480,"In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.","Is the triple ""Sodium Chloride causes Shock"" supported by the sentence: ""In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.""?",False, -7871886,Sodium Chloride causes Hypernatremia,1481,"Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').","Is the triple ""Sodium Chloride causes Hypernatremia"" supported by the sentence: ""Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').""?",False, -7769838,Sodium Chloride causes Pain,1482,The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.,"Is the triple ""Sodium Chloride causes Pain"" supported by the sentence: ""The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.""?",False, -7535626,Sodium Chloride causes pulmonary edema,1483,"The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.","Is the triple ""Sodium Chloride causes pulmonary edema"" supported by the sentence: ""The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.""?",False, -7170398,Sodium Chloride causes cataract,1484,"Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.","Is the triple ""Sodium Chloride causes cataract"" supported by the sentence: ""Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.""?",False, -7067270,Sodium Chloride causes hypertensive disorder,1485,"The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.","Is the triple ""Sodium Chloride causes hypertensive disorder"" supported by the sentence: ""The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.""?",False, -27640062,Sodium Chloride affects hyperinsulinism,1486,Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.,"Is the triple ""Sodium Chloride affects hyperinsulinism"" supported by the sentence: ""Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.""?",False, -27459630,Sodium Chloride affects ischemic disease,1487,"In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.","Is the triple ""Sodium Chloride affects ischemic disease"" supported by the sentence: ""In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.""?",False, -26883243,Sodium Chloride affects pulmonary edema,1488,"The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.","Is the triple ""Sodium Chloride affects pulmonary edema"" supported by the sentence: ""The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.""?",False, -25873721,Sodium Chloride affects stroke disorder,1489,Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].,"Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].""?",False, -25698961,Sodium Chloride affects Hypovolemia,1490,"However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.","Is the triple ""Sodium Chloride affects Hypovolemia"" supported by the sentence: ""However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.""?",False, -23350231,Sodium Chloride affects allergic disease,1491,"Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.""?",False, -21279163,Sodium Chloride affects Postoperative Nausea and Vomiting,1492,Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride affects Postoperative Nausea and Vomiting"" supported by the sentence: ""Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.""?",False, -19916489,Sodium Chloride affects malaria,1493,"The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.""?",False, -19654566,Sodium Chloride affects Fever,1494,The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.,"Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.""?",False, -19387644,Sodium Chloride affects Dyspnea,1495,The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.,"Is the triple ""Sodium Chloride affects Dyspnea"" supported by the sentence: ""The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.""?",False, -19198162,Sodium Chloride affects Hyperhidrosis,1496,"ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.""?",False, -19068195,Sodium Chloride affects Pain,1497,RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.,"Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.""?",False, -18857149,Sodium Chloride affects injury,1498,We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.""?",False, -18063112,Sodium Chloride affects myocardial infarction,1499,Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.,"Is the triple ""Sodium Chloride affects myocardial infarction"" supported by the sentence: ""Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.""?",False, -17981225,Sodium Chloride affects Fever,1500,"The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.""?",False, -17956116,Sodium Chloride affects Hyponatremia,1501,Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.,"Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.""?",False, -17749046,Sodium Chloride affects asthma,1502,The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.""?",False, -17453252,Sodium Chloride affects Hyperhidrosis,1503,"The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.""?",False, -17320603,Sodium Chloride affects brain injury,1504,"STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.""?",False, -17252322,Sodium Chloride affects iron deficiency anemia,1505,"At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.","Is the triple ""Sodium Chloride affects iron deficiency anemia"" supported by the sentence: ""At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.""?",False, -17081119,Sodium Chloride affects cataract,1506,PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride affects cataract"" supported by the sentence: ""PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.""?",False, -17021361,Sodium Chloride affects urticaria,1507,"CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.","Is the triple ""Sodium Chloride affects urticaria"" supported by the sentence: ""CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.""?",False, -16829226,Sodium Chloride affects osteoarthritis,1508,"The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.","Is the triple ""Sodium Chloride affects osteoarthritis"" supported by the sentence: ""The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.""?",False, -16392979,Sodium Chloride affects Sepsis,1509,Effects of hydrogen-rich saline treatment on polymicrobial sepsis.,"Is the triple ""Sodium Chloride affects Sepsis"" supported by the sentence: ""Effects of hydrogen-rich saline treatment on polymicrobial sepsis.""?",False, -16339812,Sodium Chloride affects Inflammation,1510,OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.,"Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.""?",False, -16191401,Sodium Chloride affects Shock,1511,"When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.","Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.""?",False, -16150899,Sodium Chloride affects severe cutaneous adverse reaction,1512,Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.,"Is the triple ""Sodium Chloride affects severe cutaneous adverse reaction"" supported by the sentence: ""Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.""?",False, -15784044,Sodium Chloride affects Electrolytes,1513,From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.,"Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.""?",False, -15684126,Sodium Chloride affects malaria,1514,"Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.""?",False, -15518572,Sodium Chloride affects ischemia reperfusion injury,1515,This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.,"Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.""?",False, -15358630,Sodium Chloride affects brain injury,1516,"Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.""?",False, -14974493,Sodium Chloride affects cardiovascular disorder,1517,"OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.","Is the triple ""Sodium Chloride affects cardiovascular disorder"" supported by the sentence: ""OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.""?",False, -14875621,Sodium Chloride affects Hypoxemia,1518,"CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.","Is the triple ""Sodium Chloride affects Hypoxemia"" supported by the sentence: ""CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.""?",False, -14652078,Sodium Chloride affects preeclampsia,1519,Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.,"Is the triple ""Sodium Chloride affects preeclampsia"" supported by the sentence: ""Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.""?",False, -14650670,Sodium Chloride affects Ascites,1520,In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.""?",False, -14454543,Sodium Chloride affects Inflammation,1521,"Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.","Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.""?",False, -14269847,Sodium Chloride affects kidney disorder,1522,"Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.","Is the triple ""Sodium Chloride affects kidney disorder"" supported by the sentence: ""Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.""?",False, -13713189,Sodium Chloride affects acute lung injury,1523,Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.,"Is the triple ""Sodium Chloride affects acute lung injury"" supported by the sentence: ""Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.""?",False, -13361928,Sodium Chloride affects cardiac rhythm disease,1524,"This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.","Is the triple ""Sodium Chloride affects cardiac rhythm disease"" supported by the sentence: ""This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.""?",False, -13091031,Sodium Chloride affects ischemia reperfusion injury,1525,"Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.","Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.""?",False, -12113298,Sodium Chloride affects diabetes mellitus,1526,"The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.","Is the triple ""Sodium Chloride affects diabetes mellitus"" supported by the sentence: ""The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.""?",False, -11936868,Sodium Chloride affects allergic disease,1527,"In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.""?",False, -11761266,Sodium Chloride affects stroke disorder,1528,"CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.","Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.""?",False, -11373059,Sodium Chloride affects Pain,1529,"In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.","Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.""?",False, -11352407,Sodium Chloride affects hypotensive disorder,1530,"Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.","Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.""?",False, -10762234,Sodium Chloride affects hypotensive disorder,1531,[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].,"Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].""?",False, -10689150,Sodium Chloride affects Hemorrhage,1532,"The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).""?",False, -10555492,Sodium Chloride affects nutritional disorder,1533,[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].,"Is the triple ""Sodium Chloride affects nutritional disorder"" supported by the sentence: ""[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].""?",False, -10543207,Sodium Chloride affects myocarditis,1534,"Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.","Is the triple ""Sodium Chloride affects myocarditis"" supported by the sentence: ""Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.""?",False, -10409590,Sodium Chloride affects essential hypertension,1535,"The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.","Is the triple ""Sodium Chloride affects essential hypertension"" supported by the sentence: ""The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.""?",False, -10373089,Sodium Chloride affects Hypernatremia,1536,"Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.","Is the triple ""Sodium Chloride affects Hypernatremia"" supported by the sentence: ""Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.""?",False, -10347664,Sodium Chloride affects neoplasm,1537,"However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.","Is the triple ""Sodium Chloride affects neoplasm"" supported by the sentence: ""However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.""?",False, -10303742,Sodium Chloride affects Hemorrhage,1538,"In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.""?",False, -10216887,Sodium Chloride affects Shock,1539,Refolding of a high molecular weight protein: salt effect on collapse.,"Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""Refolding of a high molecular weight protein: salt effect on collapse.""?",False, -10038950,Sodium Chloride affects injury,1540,This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.""?",False, -9833746,Sodium Chloride affects obesity disorder,1541,"Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.","Is the triple ""Sodium Chloride affects obesity disorder"" supported by the sentence: ""Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.""?",False, -9701968,Sodium Chloride affects brain edema,1542,The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.,"Is the triple ""Sodium Chloride affects brain edema"" supported by the sentence: ""The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.""?",False, -9235049,Sodium Chloride affects Hyponatremia,1543,"Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.","Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.""?",False, -9211629,Sodium Chloride affects asthma,1544,OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.""?",False, -8885675,Sodium Chloride affects Ascites,1545,The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.""?",False, -8142503,Sodium Chloride affects Insulin resistance,1546,"These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.","Is the triple ""Sodium Chloride affects Insulin resistance"" supported by the sentence: ""These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.""?",False, -7538296,Sodium Chloride affects depressive disorder,1547,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, -7487288,Sodium Chloride affects Hemorrhage,1548,Epinephrine in bupivacaine or saline reduced peroperative bleeding.,"Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""Epinephrine in bupivacaine or saline reduced peroperative bleeding.""?",False, -7249676,Sodium Chloride affects Fever,1549,"By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.""?",False, -7189372,Sodium Chloride affects depressive disorder,1550,"Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.""?",False, -7186849,Sodium Chloride affects hypertensive disorder,1551,"Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.","Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.""?",False, -7146026,Sodium Chloride affects hypertensive disorder,1552,This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.,"Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.""?",False, -10370500,Sodium Chloride affects Electrolytes,1553,"As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.","Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.""?",False, -14010559,Sodium Chloride produces hypertensive disorder,1554,Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.,"Is the triple ""Sodium Chloride produces hypertensive disorder"" supported by the sentence: ""Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.""?",False, -25864505,Sodium Chloride disrupts malaria,1555,A trial of chloroquine-medicated salt for malaria suppression in Uganda.,"Is the triple ""Sodium Chloride disrupts malaria"" supported by the sentence: ""A trial of chloroquine-medicated salt for malaria suppression in Uganda.""?",False, -19817939,Sodium Chloride disrupts chronic obstructive pulmonary disease,1556,Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.,"Is the triple ""Sodium Chloride disrupts chronic obstructive pulmonary disease"" supported by the sentence: ""Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.""?",False, -19569177,Sodium Chloride disrupts anxiety,1557,Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.,"Is the triple ""Sodium Chloride disrupts anxiety"" supported by the sentence: ""Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.""?",False, -19347835,Sodium Chloride disrupts cardiac rhythm disease,1558,Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.,"Is the triple ""Sodium Chloride disrupts cardiac rhythm disease"" supported by the sentence: ""Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.""?",False, -19339201,Sodium Chloride disrupts Cough,1559,"On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.","Is the triple ""Sodium Chloride disrupts Cough"" supported by the sentence: ""On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.""?",False, -18711875,Sodium Chloride disrupts pulmonary edema,1560,"Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.","Is the triple ""Sodium Chloride disrupts pulmonary edema"" supported by the sentence: ""Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.""?",False, -18638520,Sodium Chloride disrupts brain edema,1561,TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.,"Is the triple ""Sodium Chloride disrupts brain edema"" supported by the sentence: ""TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.""?",False, -18394970,Sodium Chloride disrupts Inflammation,1562,"In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.","Is the triple ""Sodium Chloride disrupts Inflammation"" supported by the sentence: ""In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.""?",False, -17319016,Sodium Chloride disrupts dental caries,1563,"Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.","Is the triple ""Sodium Chloride disrupts dental caries"" supported by the sentence: ""Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.""?",False, -17223012,Sodium Chloride disrupts hypertensive disorder,1564,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts hypertensive disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, -17223011,Sodium Chloride disrupts cardiovascular disorder,1565,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts cardiovascular disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, -17009512,Sodium Chloride disrupts allergic disease,1566,"Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.","Is the triple ""Sodium Chloride disrupts allergic disease"" supported by the sentence: ""Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.""?",False, -13585452,Sodium Chloride disrupts neoplasm,1567,"Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.","Is the triple ""Sodium Chloride disrupts neoplasm"" supported by the sentence: ""Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.""?",False, -12586414,Sodium Chloride disrupts Hypoxemia,1568,"Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.","Is the triple ""Sodium Chloride disrupts Hypoxemia"" supported by the sentence: ""Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.""?",False, -12214170,Sodium Chloride disrupts injury,1569,"Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.","Is the triple ""Sodium Chloride disrupts injury"" supported by the sentence: ""Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.""?",False, -10927798,Sodium Chloride disrupts stroke disorder,1570,"The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.","Is the triple ""Sodium Chloride disrupts stroke disorder"" supported by the sentence: ""The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.""?",False, -8273399,Sodium Chloride disrupts Pain,1571,Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.,"Is the triple ""Sodium Chloride disrupts Pain"" supported by the sentence: ""Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.""?",False, -27207716,Sodium Chloride prevents periodontal disorder,1572,"Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.","Is the triple ""Sodium Chloride prevents periodontal disorder"" supported by the sentence: ""Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.""?",False, -27075073,Sodium Chloride prevents subarachnoid hemorrhage,1573,"The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.","Is the triple ""Sodium Chloride prevents subarachnoid hemorrhage"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.""?",False, -23771600,Sodium Chloride prevents sinusitis,1574,Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.,"Is the triple ""Sodium Chloride prevents sinusitis"" supported by the sentence: ""Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.""?",False, -21279166,Sodium Chloride prevents Postoperative Nausea and Vomiting,1575,Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.""?",False, -20586429,Sodium Chloride prevents stroke disorder,1576,"In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).","Is the triple ""Sodium Chloride prevents stroke disorder"" supported by the sentence: ""In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).""?",False, -20472317,Sodium Chloride prevents myocardial infarction,1577,This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.,"Is the triple ""Sodium Chloride prevents myocardial infarction"" supported by the sentence: ""This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.""?",False, -20150308,Sodium Chloride prevents Chronic pain,1578,"Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.","Is the triple ""Sodium Chloride prevents Chronic pain"" supported by the sentence: ""Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.""?",False, -20050861,Sodium Chloride prevents Dyspnea,1579,DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.,"Is the triple ""Sodium Chloride prevents Dyspnea"" supported by the sentence: ""DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.""?",False, -19622277,Sodium Chloride prevents Pruritus,1580,"IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).","Is the triple ""Sodium Chloride prevents Pruritus"" supported by the sentence: ""IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).""?",False, -19347836,Sodium Chloride prevents cardiac rhythm disease,1581,"Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.","Is the triple ""Sodium Chloride prevents cardiac rhythm disease"" supported by the sentence: ""Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.""?",False, -18643598,Sodium Chloride prevents ventricular tachycardia,1582,"Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.","Is the triple ""Sodium Chloride prevents ventricular tachycardia"" supported by the sentence: ""Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.""?",False, -18145237,Sodium Chloride prevents Nausea,1583,The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).,"Is the triple ""Sodium Chloride prevents Nausea"" supported by the sentence: ""The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).""?",False, -17285701,Sodium Chloride prevents neuralgia,1584,"In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).","Is the triple ""Sodium Chloride prevents neuralgia"" supported by the sentence: ""In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).""?",False, -17081118,Sodium Chloride prevents cataract,1585,CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride prevents cataract"" supported by the sentence: ""CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.""?",False, -16603496,Sodium Chloride prevents brain injury,1586,DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.,"Is the triple ""Sodium Chloride prevents brain injury"" supported by the sentence: ""DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.""?",False, -16427621,Sodium Chloride prevents diabetes mellitus,1587,"Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.","Is the triple ""Sodium Chloride prevents diabetes mellitus"" supported by the sentence: ""Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.""?",False, -16310359,Sodium Chloride prevents burn,1588,CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.,"Is the triple ""Sodium Chloride prevents burn"" supported by the sentence: ""CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.""?",False, -16010295,Sodium Chloride prevents ischemic disease,1589,These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.,"Is the triple ""Sodium Chloride prevents ischemic disease"" supported by the sentence: ""These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.""?",False, -15507954,Sodium Chloride prevents pulmonary arterial hypertension,1590,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.","Is the triple ""Sodium Chloride prevents pulmonary arterial hypertension"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.""?",False, -15307837,Sodium Chloride prevents acute lung injury,1591,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.","Is the triple ""Sodium Chloride prevents acute lung injury"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.""?",False, -15219283,Sodium Chloride prevents allergic disease,1592,"KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.","Is the triple ""Sodium Chloride prevents allergic disease"" supported by the sentence: ""KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.""?",False, -14919203,Sodium Chloride prevents spinal cord injury,1593,Hydrogen-rich saline protects against spinal cord injury in rats.,"Is the triple ""Sodium Chloride prevents spinal cord injury"" supported by the sentence: ""Hydrogen-rich saline protects against spinal cord injury in rats.""?",False, -14359710,Sodium Chloride prevents obesity disorder,1594,"METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.","Is the triple ""Sodium Chloride prevents obesity disorder"" supported by the sentence: ""METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.""?",False, -14313516,Sodium Chloride prevents Inflammation,1595,"In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.","Is the triple ""Sodium Chloride prevents Inflammation"" supported by the sentence: ""In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.""?",False, -14313515,Sodium Chloride prevents ischemia reperfusion injury,1596,Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.,"Is the triple ""Sodium Chloride prevents ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.""?",False, -13297854,Sodium Chloride prevents kidney disorder,1597,"In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.","Is the triple ""Sodium Chloride prevents kidney disorder"" supported by the sentence: ""In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.""?",False, -12464836,Sodium Chloride prevents malaria,1598,"The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.","Is the triple ""Sodium Chloride prevents malaria"" supported by the sentence: ""The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.""?",False, -12453134,Sodium Chloride prevents iron deficiency anemia,1599,Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).,"Is the triple ""Sodium Chloride prevents iron deficiency anemia"" supported by the sentence: ""Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).""?",False, -12276610,Sodium Chloride prevents essential hypertension,1600,The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.,"Is the triple ""Sodium Chloride prevents essential hypertension"" supported by the sentence: ""The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.""?",False, -12092501,Sodium Chloride prevents hypertensive disorder,1601,"Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.","Is the triple ""Sodium Chloride prevents hypertensive disorder"" supported by the sentence: ""Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.""?",False, -11205687,Sodium Chloride prevents acute kidney failure,1602,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Chloride prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, -10429352,Sodium Chloride prevents injury,1603,"Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.","Is the triple ""Sodium Chloride prevents injury"" supported by the sentence: ""Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.""?",False, -10205494,Sodium Chloride prevents Hypovolemia,1604,"Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.","Is the triple ""Sodium Chloride prevents Hypovolemia"" supported by the sentence: ""Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.""?",False, -9628485,Sodium Chloride prevents anemia,1605,The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.,"Is the triple ""Sodium Chloride prevents anemia"" supported by the sentence: ""The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.""?",False, -8227059,Sodium Chloride prevents Shock,1606,The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.,"Is the triple ""Sodium Chloride prevents Shock"" supported by the sentence: ""The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.""?",False, -8196581,Sodium Chloride prevents dental caries,1607,Fluorinated salt was added to rations of preschool children for preventing dental caries.,"Is the triple ""Sodium Chloride prevents dental caries"" supported by the sentence: ""Fluorinated salt was added to rations of preschool children for preventing dental caries.""?",False, -8059428,Sodium Chloride prevents Pain,1608,"RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.","Is the triple ""Sodium Chloride prevents Pain"" supported by the sentence: ""RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.""?",False, -22103068,Sodium Chloride exacerbates hypertensive disorder,1609,The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.,"Is the triple ""Sodium Chloride exacerbates hypertensive disorder"" supported by the sentence: ""The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.""?",False, -20308305,Sodium Chloride exacerbates Inflammation,1610,"NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.","Is the triple ""Sodium Chloride exacerbates Inflammation"" supported by the sentence: ""NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.""?",False, -21816011,Sodium Chloride predisposes essential hypertension,1611,"This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.","Is the triple ""Sodium Chloride predisposes essential hypertension"" supported by the sentence: ""This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.""?",False, -19774957,Sodium Chloride predisposes pulmonary edema,1612,"Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.","Is the triple ""Sodium Chloride predisposes pulmonary edema"" supported by the sentence: ""Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.""?",False, -18380691,Sodium Chloride predisposes myocardial infarction,1613,"Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.","Is the triple ""Sodium Chloride predisposes myocardial infarction"" supported by the sentence: ""Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.""?",False, -18041213,Sodium Chloride predisposes Inflammation,1614,The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.,"Is the triple ""Sodium Chloride predisposes Inflammation"" supported by the sentence: ""The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.""?",False, -16033022,Sodium Chloride predisposes injury,1615,"In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.","Is the triple ""Sodium Chloride predisposes injury"" supported by the sentence: ""In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.""?",False, -13840593,Sodium Chloride predisposes allergic disease,1616,IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.,"Is the triple ""Sodium Chloride predisposes allergic disease"" supported by the sentence: ""IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.""?",False, -13808663,Sodium Chloride predisposes diabetes mellitus,1617,"Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.","Is the triple ""Sodium Chloride predisposes diabetes mellitus"" supported by the sentence: ""Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.""?",False, -13731023,Sodium Chloride predisposes cardiovascular disorder,1618,It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.,"Is the triple ""Sodium Chloride predisposes cardiovascular disorder"" supported by the sentence: ""It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.""?",False, -12280034,Sodium Chloride predisposes neoplasm,1619,"The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.","Is the triple ""Sodium Chloride predisposes neoplasm"" supported by the sentence: ""The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.""?",False, -12079247,Sodium Chloride predisposes hypertensive disorder,1620,"Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.","Is the triple ""Sodium Chloride predisposes hypertensive disorder"" supported by the sentence: ""Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.""?",False, -11776631,Sodium Chloride predisposes stroke disorder,1621,"These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.","Is the triple ""Sodium Chloride predisposes stroke disorder"" supported by the sentence: ""These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.""?",False, -11266800,Sodium Chloride predisposes kidney disorder,1622,"The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.","Is the triple ""Sodium Chloride predisposes kidney disorder"" supported by the sentence: ""The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.""?",False, -10118531,Sodium Chloride predisposes obesity disorder,1623,"To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).","Is the triple ""Sodium Chloride predisposes obesity disorder"" supported by the sentence: ""To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).""?",False, -9111875,Sodium Chloride predisposes cardiac rhythm disease,1624,"Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).","Is the triple ""Sodium Chloride predisposes cardiac rhythm disease"" supported by the sentence: ""Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).""?",False, -9647073,Dexpanthenol related to skin disorder,1625,Topical use of dexpanthenol in skin disorders.,"Is the triple ""Dexpanthenol related to skin disorder"" supported by the sentence: ""Topical use of dexpanthenol in skin disorders.""?",False, -26305399,Dexpanthenol affects Erythema,1626,"Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.","Is the triple ""Dexpanthenol affects Erythema"" supported by the sentence: ""Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.""?",False, -25421467,Dexpanthenol prevents cheilitis,1627,OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.,"Is the triple ""Dexpanthenol prevents cheilitis"" supported by the sentence: ""OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.""?",False, -24024712,ELTROMBOPAG related to autoimmune thrombocytopenic purpura,1628,"CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.","Is the triple ""ELTROMBOPAG related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.""?",False, -22097814,ELTROMBOPAG related to acute myeloid leukemia,1629,A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.,"Is the triple ""ELTROMBOPAG related to acute myeloid leukemia"" supported by the sentence: ""A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.""?",False, -22063304,ELTROMBOPAG related to aplastic anemia,1630,The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.,"Is the triple ""ELTROMBOPAG related to aplastic anemia"" supported by the sentence: ""The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.""?",False, -22063303,ELTROMBOPAG related to myelodysplastic syndrome,1631,We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.,"Is the triple ""ELTROMBOPAG related to myelodysplastic syndrome"" supported by the sentence: ""We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.""?",False, -22049758,ELTROMBOPAG related to thrombocytopenia,1632,"Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.","Is the triple ""ELTROMBOPAG related to thrombocytopenia"" supported by the sentence: ""Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.""?",False, -23835836,ELTROMBOPAG causes anemia,1633,This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.,"Is the triple ""ELTROMBOPAG causes anemia"" supported by the sentence: ""This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.""?",False, -22601227,ELTROMBOPAG affects thrombocytopenia,1634,The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.""?",False, -21709185,ELTROMBOPAG affects thrombocytopenia,1635,We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.""?",False, -22821304,ELTROMBOPAG prevents Hemorrhage,1636,"Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.","Is the triple ""ELTROMBOPAG prevents Hemorrhage"" supported by the sentence: ""Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.""?",False, -22169266,ELTROMBOPAG prevents thrombocytopenia,1637,We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.,"Is the triple ""ELTROMBOPAG prevents thrombocytopenia"" supported by the sentence: ""We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.""?",False, -12546229,Etamsylate affects Hemorrhage,1638,"Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.","Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.""?",False, -9791897,Etamsylate affects Hemorrhage,1639,Effect of Etamsylate on menstrual blood loss in women using IUDs.,"Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Effect of Etamsylate on menstrual blood loss in women using IUDs.""?",False, -22608563,Etamsylate prevents Hemorrhage,1640,Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.,"Is the triple ""Etamsylate prevents Hemorrhage"" supported by the sentence: ""Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.""?",False, -26536250,mitomycin C related to Deoxyribonucleic acid,1641,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, -26536250,mitomycin C related to Deoxyribonucleic acid,1642,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, -26158944,mitomycin C related to adenocarcinoma,1643,"Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.","Is the triple ""mitomycin C related to adenocarcinoma"" supported by the sentence: ""Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.""?",False, -26111339,mitomycin C related to squamous cell carcinoma,1644,"Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.","Is the triple ""mitomycin C related to squamous cell carcinoma"" supported by the sentence: ""Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.""?",False, -26043076,mitomycin C related to neoplasm,1645,"The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.","Is the triple ""mitomycin C related to neoplasm"" supported by the sentence: ""The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.""?",False, -25722815,mitomycin C related to leukemia,1646,"Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.","Is the triple ""mitomycin C related to leukemia"" supported by the sentence: ""Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.""?",False, -12722759,mitomycin C related to carcinoma,1647,"Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.","Is the triple ""mitomycin C related to carcinoma"" supported by the sentence: ""Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.""?",False, -10467532,mitomycin C related to non-small cell lung carcinoma,1648,"A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.","Is the triple ""mitomycin C related to non-small cell lung carcinoma"" supported by the sentence: ""A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.""?",False, -7255625,mitomycin C related to Deoxyribonucleic acid,1649,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, -7255625,mitomycin C related to Deoxyribonucleic acid,1650,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, -8689799,mitomycin C coexists with Deoxyribonucleic acid,1651,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, -8689799,mitomycin C coexists with Deoxyribonucleic acid,1652,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, -8030161,mitomycin C coexists with Deoxyribonucleic acid,1653,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, -8030161,mitomycin C coexists with Deoxyribonucleic acid,1654,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, -7255626,mitomycin C physically interacts with Deoxyribonucleic acid,1655,"Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.","Is the triple ""mitomycin C physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.""?",False, -25769130,mitomycin C causes sarcoma,1656,"Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.","Is the triple ""mitomycin C causes sarcoma"" supported by the sentence: ""Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.""?",False, -25692678,mitomycin C causes hepatocellular carcinoma,1657,The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.,"Is the triple ""mitomycin C causes hepatocellular carcinoma"" supported by the sentence: ""The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.""?",False, -20975852,mitomycin C causes carcinoma,1658,CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.,"Is the triple ""mitomycin C causes carcinoma"" supported by the sentence: ""CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.""?",False, -12184177,mitomycin C causes Corneal opacity,1659,"When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.","Is the triple ""mitomycin C causes Corneal opacity"" supported by the sentence: ""When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.""?",False, -11626710,mitomycin C causes urethral stricture,1660,Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.,"Is the triple ""mitomycin C causes urethral stricture"" supported by the sentence: ""Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.""?",False, -9485346,mitomycin C causes neoplasm,1661,The influence of mitomycin C on the induction of crown-gall tumors.,"Is the triple ""mitomycin C causes neoplasm"" supported by the sentence: ""The influence of mitomycin C on the induction of crown-gall tumors.""?",False, -26017044,mitomycin C affects squamous cell carcinoma,1662,Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.,"Is the triple ""mitomycin C affects squamous cell carcinoma"" supported by the sentence: ""Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.""?",False, -25924198,mitomycin C affects adenocarcinoma,1663,Effect of mitomycin-C on McCall rat colon adenocarcinoma.,"Is the triple ""mitomycin C affects adenocarcinoma"" supported by the sentence: ""Effect of mitomycin-C on McCall rat colon adenocarcinoma.""?",False, -24961205,mitomycin C affects neoplasm,1664,"CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.""?",False, -21183193,mitomycin C affects transitional cell carcinoma,1665,Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.,"Is the triple ""mitomycin C affects transitional cell carcinoma"" supported by the sentence: ""Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.""?",False, -20995393,mitomycin C affects urinary bladder neoplasm,1666,"Instillation of MMC markedly increased the development of bladder tumors, although CA did not.","Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""Instillation of MMC markedly increased the development of bladder tumors, although CA did not.""?",False, -20865956,mitomycin C affects pterygium,1667,Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.,"Is the triple ""mitomycin C affects pterygium"" supported by the sentence: ""Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.""?",False, -17166086,mitomycin C affects mesothelioma,1668,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""mitomycin C affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, -15342296,mitomycin C affects sclerosing cholangitis,1669,Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.,"Is the triple ""mitomycin C affects sclerosing cholangitis"" supported by the sentence: ""Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.""?",False, -14897135,mitomycin C affects Corneal opacity,1670,PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.,"Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.""?",False, -14480408,mitomycin C affects liver and intrahepatic bile duct neoplasm,1671,"The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.","Is the triple ""mitomycin C affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.""?",False, -14435862,mitomycin C affects Corneal opacity,1672,"Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.","Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.""?",False, -10146530,mitomycin C affects open-angle glaucoma,1673,A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.,"Is the triple ""mitomycin C affects open-angle glaucoma"" supported by the sentence: ""A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.""?",False, -8885108,mitomycin C affects urinary bladder neoplasm,1674,These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.,"Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.""?",False, -8612675,mitomycin C affects Deoxyribonucleic acid,1675,It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.,"Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.""?",False, -8242643,mitomycin C affects neoplasm,1676,"CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.""?",False, -8428809,mitomycin C affects Deoxyribonucleic acid,1677,"DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.","Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.""?",False, -26926271,mitomycin C disrupts Neoplasm Metastasis,1678,"When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.","Is the triple ""mitomycin C disrupts Neoplasm Metastasis"" supported by the sentence: ""When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.""?",False, -21172443,mitomycin C disrupts urinary bladder neoplasm,1679,"However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.","Is the triple ""mitomycin C disrupts urinary bladder neoplasm"" supported by the sentence: ""However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.""?",False, -16608751,mitomycin C disrupts carcinoma,1680,RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.,"Is the triple ""mitomycin C disrupts carcinoma"" supported by the sentence: ""RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.""?",False, -12093037,mitomycin C disrupts neoplasm,1681,"As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.","Is the triple ""mitomycin C disrupts neoplasm"" supported by the sentence: ""As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.""?",False, -8920186,mitomycin C disrupts Corneal opacity,1682,CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.,"Is the triple ""mitomycin C disrupts Corneal opacity"" supported by the sentence: ""CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.""?",False, -22973529,mitomycin C prevents glaucoma,1683,"CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.","Is the triple ""mitomycin C prevents glaucoma"" supported by the sentence: ""CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.""?",False, -19902018,mitomycin C prevents keratoconus,1684,Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.,"Is the triple ""mitomycin C prevents keratoconus"" supported by the sentence: ""Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.""?",False, -19673685,mitomycin C prevents urethral stricture,1685,Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.,"Is the triple ""mitomycin C prevents urethral stricture"" supported by the sentence: ""Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.""?",False, -12959208,mitomycin C prevents Neoplasm Metastasis,1686,"Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.","Is the triple ""mitomycin C prevents Neoplasm Metastasis"" supported by the sentence: ""Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.""?",False, -11642092,mitomycin C prevents Esophageal stenosis,1687,"The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.","Is the triple ""mitomycin C prevents Esophageal stenosis"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.""?",False, -9925117,mitomycin C prevents neoplasm,1688,"An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).","Is the triple ""mitomycin C prevents neoplasm"" supported by the sentence: ""An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).""?",False, -8410588,mitomycin C prevents pterygium,1689,"CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.","Is the triple ""mitomycin C prevents pterygium"" supported by the sentence: ""CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.""?",False, -7308263,mitomycin C prevents urinary bladder neoplasm,1690,"CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.","Is the triple ""mitomycin C prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.""?",False, -20886584,mitomycin C predisposes neoplasm,1691,These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.,"Is the triple ""mitomycin C predisposes neoplasm"" supported by the sentence: ""These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.""?",False, -17638153,Cefazolin related to bone fracture,1692,"The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.","Is the triple ""Cefazolin related to bone fracture"" supported by the sentence: ""The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.""?",False, -20958121,Cefazolin causes bacterial infectious disease with sepsis,1693,BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.,"Is the triple ""Cefazolin causes bacterial infectious disease with sepsis"" supported by the sentence: ""BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.""?",False, -25339548,Cefazolin affects obesity disorder,1694,"Overall, cefazolin pharmacokinetics are substantially altered in obesity.","Is the triple ""Cefazolin affects obesity disorder"" supported by the sentence: ""Overall, cefazolin pharmacokinetics are substantially altered in obesity.""?",False, -27670629,Cefazolin prevents staphylococcal infection,1695,PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.,"Is the triple ""Cefazolin prevents staphylococcal infection"" supported by the sentence: ""PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.""?",False, -10537097,Cefazolin prevents bacterial infectious disease,1696,"The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.","Is the triple ""Cefazolin prevents bacterial infectious disease"" supported by the sentence: ""The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.""?",False, -7415834,Famciclovir affects herpes zoster,1697,"However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.","Is the triple ""Famciclovir affects herpes zoster"" supported by the sentence: ""However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.""?",False, -27310156,Famciclovir disrupts viral infectious disease,1698,Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.,"Is the triple ""Famciclovir disrupts viral infectious disease"" supported by the sentence: ""Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.""?",False, -11859744,Famciclovir disrupts herpes simplex infectious disease,1699,OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.,"Is the triple ""Famciclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.""?",False, -11859743,Famciclovir disrupts genital herpes,1700,Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.,"Is the triple ""Famciclovir disrupts genital herpes"" supported by the sentence: ""Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.""?",False, -7415831,Famciclovir prevents herpes zoster,1701,"In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.","Is the triple ""Famciclovir prevents herpes zoster"" supported by the sentence: ""In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.""?",False, -27248580,Acyclovir related to herpes zoster,1702,Effect of acyclovir and prednisolone on the serological response in herpes zoster.,"Is the triple ""Acyclovir related to herpes zoster"" supported by the sentence: ""Effect of acyclovir and prednisolone on the serological response in herpes zoster.""?",False, -20916830,Acyclovir causes viral infectious disease,1703,"Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.","Is the triple ""Acyclovir causes viral infectious disease"" supported by the sentence: ""Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.""?",False, -21459205,Acyclovir affects herpes zoster,1704,"Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.","Is the triple ""Acyclovir affects herpes zoster"" supported by the sentence: ""Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.""?",False, -17108497,Acyclovir affects genital herpes,1705,In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.,"Is the triple ""Acyclovir affects genital herpes"" supported by the sentence: ""In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.""?",False, -15677184,Acyclovir affects viral infectious disease,1706,The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.,"Is the triple ""Acyclovir affects viral infectious disease"" supported by the sentence: ""The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.""?",False, -9966648,Acyclovir affects chickenpox,1707,2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.,"Is the triple ""Acyclovir affects chickenpox"" supported by the sentence: ""2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.""?",False, -8137898,Acyclovir affects cytomegalovirus infection,1708,"In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.","Is the triple ""Acyclovir affects cytomegalovirus infection"" supported by the sentence: ""In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.""?",False, -26100053,Acyclovir disrupts herpes zoster,1709,"When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.","Is the triple ""Acyclovir disrupts herpes zoster"" supported by the sentence: ""When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.""?",False, -21196251,Acyclovir disrupts cytomegalovirus infection,1710,"METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.","Is the triple ""Acyclovir disrupts cytomegalovirus infection"" supported by the sentence: ""METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.""?",False, -21045605,Acyclovir disrupts herpes simplex infectious disease,1711,Bortezomib and acyclovir acted synergistically to inhibit HSV infection.,"Is the triple ""Acyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Bortezomib and acyclovir acted synergistically to inhibit HSV infection.""?",False, -13979845,Acyclovir disrupts HIV infectious disease,1712,"In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.","Is the triple ""Acyclovir disrupts HIV infectious disease"" supported by the sentence: ""In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.""?",False, -11163493,Acyclovir disrupts chickenpox,1713,BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.,"Is the triple ""Acyclovir disrupts chickenpox"" supported by the sentence: ""BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.""?",False, -10081763,Acyclovir disrupts viral infectious disease,1714,"Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.","Is the triple ""Acyclovir disrupts viral infectious disease"" supported by the sentence: ""Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.""?",False, -8112053,Acyclovir disrupts genital herpes,1715,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Acyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, -22220716,Acyclovir prevents chickenpox,1716,Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.,"Is the triple ""Acyclovir prevents chickenpox"" supported by the sentence: ""Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.""?",False, -14453930,Acyclovir prevents herpes zoster,1717,Continuous administration of ACV decreased the incidence of HZ infection.,"Is the triple ""Acyclovir prevents herpes zoster"" supported by the sentence: ""Continuous administration of ACV decreased the incidence of HZ infection.""?",False, -11048138,Acyclovir prevents herpes labialis,1718,The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.,"Is the triple ""Acyclovir prevents herpes labialis"" supported by the sentence: ""The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.""?",False, -10652424,Acyclovir prevents viral infectious disease,1719,The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.,"Is the triple ""Acyclovir prevents viral infectious disease"" supported by the sentence: ""The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.""?",False, -9977810,Acyclovir prevents genital herpes,1720,CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.,"Is the triple ""Acyclovir prevents genital herpes"" supported by the sentence: ""CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.""?",False, -8973083,Acyclovir prevents cytomegalovirus infection,1721,The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.,"Is the triple ""Acyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.""?",False, -8455850,Acyclovir prevents herpes simplex infectious disease,1722,"HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.","Is the triple ""Acyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.""?",False, -16777411,Acyclovir predisposes herpes simplex infectious disease,1723,"CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.","Is the triple ""Acyclovir predisposes herpes simplex infectious disease"" supported by the sentence: ""CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.""?",False, -14602481,Acyclovir predisposes HIV infectious disease,1724,We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.,"Is the triple ""Acyclovir predisposes HIV infectious disease"" supported by the sentence: ""We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.""?",False, -7066348,Idoxuridine coexists with Deoxyribonucleic acid,1725,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, -7066348,Idoxuridine coexists with Deoxyribonucleic acid,1726,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, -10786366,Idoxuridine coexists with Deoxyribonucleic acid,1727,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, -10786366,Idoxuridine coexists with Deoxyribonucleic acid,1728,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, -15969143,Idoxuridine derives from Deoxyribonucleic acid,1729,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, -15969143,Idoxuridine derives from Deoxyribonucleic acid,1730,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, -10765452,Idoxuridine physically interacts with Deoxyribonucleic acid,1731,Role of MutSalpha in the recognition of iododeoxyuridine in DNA.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Role of MutSalpha in the recognition of iododeoxyuridine in DNA.""?",False, -8193345,Idoxuridine physically interacts with Deoxyribonucleic acid,1732,The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.""?",False, -13332148,Idoxuridine causes viral infectious disease,1733,"Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.","Is the triple ""Idoxuridine causes viral infectious disease"" supported by the sentence: ""Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.""?",False, -25762983,Idoxuridine affects viral infectious disease,1734,Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.,"Is the triple ""Idoxuridine affects viral infectious disease"" supported by the sentence: ""Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.""?",False, -25024576,Idoxuridine affects Deoxyribonucleic acid,1735,"Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.","Is the triple ""Idoxuridine affects Deoxyribonucleic acid"" supported by the sentence: ""Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.""?",False, -25798138,Vidarabine affects herpes simplex infectious disease,1736,Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.,"Is the triple ""Vidarabine affects herpes simplex infectious disease"" supported by the sentence: ""Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.""?",False, -18005400,Ganciclovir related to AIDS,1737,[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].,"Is the triple ""Ganciclovir related to AIDS"" supported by the sentence: ""[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].""?",False, -11769089,Ganciclovir related to lymphoma,1738,Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.,"Is the triple ""Ganciclovir related to lymphoma"" supported by the sentence: ""Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.""?",False, -7813894,Ganciclovir causes hepatocellular carcinoma,1739,"However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.","Is the triple ""Ganciclovir causes hepatocellular carcinoma"" supported by the sentence: ""However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.""?",False, -21315977,Ganciclovir affects melanoma,1740,"In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.","Is the triple ""Ganciclovir affects melanoma"" supported by the sentence: ""In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.""?",False, -18696617,Ganciclovir affects viral infectious disease,1741,"It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.","Is the triple ""Ganciclovir affects viral infectious disease"" supported by the sentence: ""It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.""?",False, -14018850,Ganciclovir affects graft versus host disease,1742,OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).,"Is the triple ""Ganciclovir affects graft versus host disease"" supported by the sentence: ""OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).""?",False, -7745805,Ganciclovir affects hepatocellular carcinoma,1743,"Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.","Is the triple ""Ganciclovir affects hepatocellular carcinoma"" supported by the sentence: ""Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.""?",False, -7264703,Ganciclovir affects retinitis,1744,"CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.","Is the triple ""Ganciclovir affects retinitis"" supported by the sentence: ""CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.""?",False, -7193112,Ganciclovir affects cytomegalovirus retinitis,1745,"Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.","Is the triple ""Ganciclovir affects cytomegalovirus retinitis"" supported by the sentence: ""Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.""?",False, -27515973,Ganciclovir disrupts viral infectious disease,1746,"Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.","Is the triple ""Ganciclovir disrupts viral infectious disease"" supported by the sentence: ""Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.""?",False, -20042666,Ganciclovir disrupts glioblastoma,1747,"Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.","Is the triple ""Ganciclovir disrupts glioblastoma"" supported by the sentence: ""Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.""?",False, -11829393,Ganciclovir disrupts cytomegalovirus infection,1748,CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.,"Is the triple ""Ganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.""?",False, -9242712,Ganciclovir disrupts hepatocellular carcinoma,1749,Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.,"Is the triple ""Ganciclovir disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.""?",False, -27273103,Ganciclovir prevents retinitis,1750,"TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.","Is the triple ""Ganciclovir prevents retinitis"" supported by the sentence: ""TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.""?",False, -14947813,Ganciclovir prevents viral infectious disease,1751,"This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.","Is the triple ""Ganciclovir prevents viral infectious disease"" supported by the sentence: ""This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.""?",False, -8898867,Ganciclovir prevents cytomegalovirus retinitis,1752,"Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.","Is the triple ""Ganciclovir prevents cytomegalovirus retinitis"" supported by the sentence: ""Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.""?",False, -7606615,Ganciclovir prevents cytomegalovirus infection,1753,"Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.","Is the triple ""Ganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.""?",False, -26756507,Nedocromil affects asthma,1754,"As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.","Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.""?",False, -12807968,Nedocromil affects asthma,1755,AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.,"Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.""?",False, -15773495,Nedocromil disrupts asthma,1756,Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.,"Is the triple ""Nedocromil disrupts asthma"" supported by the sentence: ""Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.""?",False, -26602335,Nedocromil prevents asthma,1757,Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.,"Is the triple ""Nedocromil prevents asthma"" supported by the sentence: ""Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.""?",False, -25857910,Flumedroxone related to migraine disorder,1758,"A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.","Is the triple ""Flumedroxone related to migraine disorder"" supported by the sentence: ""A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.""?",False, -26456255,Valrubicin coexists with Deoxyribonucleic acid,1759,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, -26456255,Valrubicin coexists with Deoxyribonucleic acid,1760,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, -26331358,Valrubicin affects Deoxyribonucleic acid,1761,The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.,"Is the triple ""Valrubicin affects Deoxyribonucleic acid"" supported by the sentence: ""The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.""?",False, -9013591,Valrubicin affects neoplasm,1762,OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).,"Is the triple ""Valrubicin affects neoplasm"" supported by the sentence: ""OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).""?",False, -15048973,Valrubicin disrupts neoplasm,1763,Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.,"Is the triple ""Valrubicin disrupts neoplasm"" supported by the sentence: ""Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.""?",False, -19780799,"Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive",1764,"BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.","Is the triple ""Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.""?",False, -19123529,Idarubicin related to acute lymphoblastic leukemia,1765,"A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.","Is the triple ""Idarubicin related to acute lymphoblastic leukemia"" supported by the sentence: ""A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.""?",False, -17160344,Idarubicin related to myelodysplastic syndrome,1766,"Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.","Is the triple ""Idarubicin related to myelodysplastic syndrome"" supported by the sentence: ""Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.""?",False, -13481436,Idarubicin related to acute myeloid leukemia,1767,Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).,"Is the triple ""Idarubicin related to acute myeloid leukemia"" supported by the sentence: ""Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).""?",False, -12261572,Idarubicin related to plasma cell myeloma,1768,"High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.","Is the triple ""Idarubicin related to plasma cell myeloma"" supported by the sentence: ""High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.""?",False, -10347974,Idarubicin related to non-Hodgkin lymphoma,1769,"Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.","Is the triple ""Idarubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.""?",False, -8798925,Idarubicin related to acute promyelocytic leukemia,1770,Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.,"Is the triple ""Idarubicin related to acute promyelocytic leukemia"" supported by the sentence: ""Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.""?",False, -17955637,Idarubicin causes acute myeloid leukemia,1771,"On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.","Is the triple ""Idarubicin causes acute myeloid leukemia"" supported by the sentence: ""On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.""?",False, -10037923,Idarubicin causes neutropenia,1772,The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.,"Is the triple ""Idarubicin causes neutropenia"" supported by the sentence: ""The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.""?",False, -27637811,Idarubicin affects acute myeloid leukemia,1773,"In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.""?",False, -27582612,Idarubicin affects acute lymphoblastic leukemia,1774,The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.,"Is the triple ""Idarubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.""?",False, -27363552,Idarubicin affects neoplasm,1775,"However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.""?",False, -10133635,Idarubicin affects acute myeloid leukemia,1776,"Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.""?",False, -9755321,Idarubicin affects leukemia,1777,"We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.","Is the triple ""Idarubicin affects leukemia"" supported by the sentence: ""We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.""?",False, -9560678,Idarubicin affects neoplasm,1778,"Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.""?",False, -9242996,Idarubicin affects neutropenia,1779,These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.,"Is the triple ""Idarubicin affects neutropenia"" supported by the sentence: ""These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.""?",False, -18342294,Pirarubicin causes neoplasm,1780,RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.,"Is the triple ""Pirarubicin causes neoplasm"" supported by the sentence: ""RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.""?",False, -16182034,Pirarubicin affects neoplasm,1781,Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.,"Is the triple ""Pirarubicin affects neoplasm"" supported by the sentence: ""Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.""?",False, -19153993,Pirarubicin disrupts neoplasm,1782,"As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.","Is the triple ""Pirarubicin disrupts neoplasm"" supported by the sentence: ""As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.""?",False, -14778803,Pirarubicin prevents neoplasm,1783,"Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.","Is the triple ""Pirarubicin prevents neoplasm"" supported by the sentence: ""Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.""?",False, -20218174,Mitoxantrone subclass of Mitoxantrone dicarboxylic acid,1784,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone subclass of Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, -25737166,Mitoxantrone related to lymphoma,1785,"Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.","Is the triple ""Mitoxantrone related to lymphoma"" supported by the sentence: ""Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.""?",False, -19961419,Mitoxantrone related to breast neoplasm,1786,Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.,"Is the triple ""Mitoxantrone related to breast neoplasm"" supported by the sentence: ""Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.""?",False, -14217137,Mitoxantrone related to mantle cell lymphoma,1787,Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.,"Is the triple ""Mitoxantrone related to mantle cell lymphoma"" supported by the sentence: ""Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.""?",False, -13051364,Mitoxantrone related to multiple sclerosis,1788,"Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.","Is the triple ""Mitoxantrone related to multiple sclerosis"" supported by the sentence: ""Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.""?",False, -8903075,Mitoxantrone related to acute myeloid leukemia,1789,"Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.","Is the triple ""Mitoxantrone related to acute myeloid leukemia"" supported by the sentence: ""Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.""?",False, -8584278,Mitoxantrone causes acute myeloid leukemia,1790,"CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.","Is the triple ""Mitoxantrone causes acute myeloid leukemia"" supported by the sentence: ""CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.""?",False, -26143277,Mitoxantrone affects lymphoma,1791,"Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.","Is the triple ""Mitoxantrone affects lymphoma"" supported by the sentence: ""Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.""?",False, -20218175,Mitoxantrone affects Mitoxantrone dicarboxylic acid,1792,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone affects Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, -11986455,Mitoxantrone affects multiple sclerosis,1793,Therapeutic role of mitoxantrone in multiple sclerosis.,"Is the triple ""Mitoxantrone affects multiple sclerosis"" supported by the sentence: ""Therapeutic role of mitoxantrone in multiple sclerosis.""?",False, -9134230,Mitoxantrone prevents neoplasm,1794,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Mitoxantrone prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, -11307631,Mitoxantrone exacerbates multiple sclerosis,1795,Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.,"Is the triple ""Mitoxantrone exacerbates multiple sclerosis"" supported by the sentence: ""Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.""?",False, -26844498,Doxorubicin related to renal cell carcinoma,1796,Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.,"Is the triple ""Doxorubicin related to renal cell carcinoma"" supported by the sentence: ""Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.""?",False, -26506763,Doxorubicin related to Kaposi's sarcoma,1797,"The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.","Is the triple ""Doxorubicin related to Kaposi's sarcoma"" supported by the sentence: ""The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.""?",False, -26097255,Doxorubicin related to hepatocellular carcinoma,1798,The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.,"Is the triple ""Doxorubicin related to hepatocellular carcinoma"" supported by the sentence: ""The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.""?",False, -25468576,Doxorubicin related to non-Hodgkin lymphoma,1799,"OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.","Is the triple ""Doxorubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.""?",False, -21586070,Doxorubicin related to diffuse large B-cell lymphoma,1800,"Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.","Is the triple ""Doxorubicin related to diffuse large B-cell lymphoma"" supported by the sentence: ""Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.""?",False, -17293414,Doxorubicin related to neoplasm,1801,"Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.","Is the triple ""Doxorubicin related to neoplasm"" supported by the sentence: ""Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.""?",False, -14824461,Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma,1802,"A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.","Is the triple ""Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.""?",False, -12975330,"Doxorubicin related to Lymphoma, AIDS-Related",1803,"BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.","Is the triple ""Doxorubicin related to Lymphoma, AIDS-Related"" supported by the sentence: ""BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.""?",False, -12635005,Doxorubicin related to neuroendocrine neoplasm,1804,"Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.","Is the triple ""Doxorubicin related to neuroendocrine neoplasm"" supported by the sentence: ""Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.""?",False, -11664648,Doxorubicin related to non-small cell lung carcinoma,1805,"Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.","Is the triple ""Doxorubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.""?",False, -8248824,Doxorubicin related to lymphoma,1806,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Doxorubicin related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, -7897058,Doxorubicin related to leukemia,1807,Combined effect of lipoic acid and doxorubicin in murine leukemia.,"Is the triple ""Doxorubicin related to leukemia"" supported by the sentence: ""Combined effect of lipoic acid and doxorubicin in murine leukemia.""?",False, -7111309,Doxorubicin related to Hodgkins lymphoma,1808,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Doxorubicin related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, -26198671,Doxorubicin causes acute myeloid leukemia,1809,"Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.","Is the triple ""Doxorubicin causes acute myeloid leukemia"" supported by the sentence: ""Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.""?",False, -20905498,Doxorubicin causes prostate cancer,1810,"In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.","Is the triple ""Doxorubicin causes prostate cancer"" supported by the sentence: ""In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.""?",False, -19998968,Doxorubicin causes Hodgkins lymphoma,1811,"Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.","Is the triple ""Doxorubicin causes Hodgkins lymphoma"" supported by the sentence: ""Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.""?",False, -17176693,Doxorubicin causes B-cell neoplasm,1812,"Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.","Is the triple ""Doxorubicin causes B-cell neoplasm"" supported by the sentence: ""Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.""?",False, -16306119,Doxorubicin causes hepatocellular carcinoma,1813,"In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.","Is the triple ""Doxorubicin causes hepatocellular carcinoma"" supported by the sentence: ""In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.""?",False, -14936910,Doxorubicin causes plasma cell myeloma,1814,"Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.","Is the triple ""Doxorubicin causes plasma cell myeloma"" supported by the sentence: ""Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.""?",False, -13613509,Doxorubicin causes sarcoma,1815,Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.,"Is the triple ""Doxorubicin causes sarcoma"" supported by the sentence: ""Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.""?",False, -12176485,"Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive",1816,"Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.","Is the triple ""Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.""?",False, -12086573,Doxorubicin causes leukemia,1817,"We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.","Is the triple ""Doxorubicin causes leukemia"" supported by the sentence: ""We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.""?",False, -11480674,Doxorubicin causes Neoplasm Metastasis,1818,"The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.","Is the triple ""Doxorubicin causes Neoplasm Metastasis"" supported by the sentence: ""The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.""?",False, -11088747,Doxorubicin causes neoplasm,1819,"Furthermore, doxorubicin is known to induce tumor resistance genes.","Is the triple ""Doxorubicin causes neoplasm"" supported by the sentence: ""Furthermore, doxorubicin is known to induce tumor resistance genes.""?",False, -7374660,Doxorubicin causes neutropenia,1820,"Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.","Is the triple ""Doxorubicin causes neutropenia"" supported by the sentence: ""Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.""?",False, -25410483,Doxorubicin affects glioma,1821,"By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.","Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.""?",False, -25202161,Doxorubicin affects glioblastoma,1822,The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.,"Is the triple ""Doxorubicin affects glioblastoma"" supported by the sentence: ""The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.""?",False, -24066270,Doxorubicin affects triple-negative breast carcinoma,1823,Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.,"Is the triple ""Doxorubicin affects triple-negative breast carcinoma"" supported by the sentence: ""Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.""?",False, -23980169,Doxorubicin affects hematopoietic and lymphoid system neoplasm,1824,"Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.","Is the triple ""Doxorubicin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.""?",False, -20976248,Doxorubicin affects neuroblastoma,1825,"For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.","Is the triple ""Doxorubicin affects neuroblastoma"" supported by the sentence: ""For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.""?",False, -20526631,Doxorubicin affects gastric neoplasm,1826,"Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.","Is the triple ""Doxorubicin affects gastric neoplasm"" supported by the sentence: ""Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.""?",False, -20464122,Doxorubicin affects T-cell non-Hodgkin lymphoma,1827,"Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.","Is the triple ""Doxorubicin affects T-cell non-Hodgkin lymphoma"" supported by the sentence: ""Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.""?",False, -19907850,Doxorubicin affects renal cell carcinoma,1828,"Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.","Is the triple ""Doxorubicin affects renal cell carcinoma"" supported by the sentence: ""Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.""?",False, -18966824,Doxorubicin affects leiomyosarcoma,1829,"Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.","Is the triple ""Doxorubicin affects leiomyosarcoma"" supported by the sentence: ""Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.""?",False, -18841320,Doxorubicin affects B-cell chronic lymphocytic leukemia,1830,This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.,"Is the triple ""Doxorubicin affects B-cell chronic lymphocytic leukemia"" supported by the sentence: ""This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.""?",False, -17410518,Doxorubicin affects rhabdomyosarcoma,1831,The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.,"Is the triple ""Doxorubicin affects rhabdomyosarcoma"" supported by the sentence: ""The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.""?",False, -17166104,Doxorubicin affects mesothelioma,1832,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""Doxorubicin affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, -17156749,Doxorubicin affects non-Hodgkin lymphoma,1833,From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).,"Is the triple ""Doxorubicin affects non-Hodgkin lymphoma"" supported by the sentence: ""From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).""?",False, -17092174,Doxorubicin affects glioma,1834,Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.,"Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.""?",False, -16319458,Doxorubicin affects sarcoma,1835,Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.,"Is the triple ""Doxorubicin affects sarcoma"" supported by the sentence: ""Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.""?",False, -15641121,Doxorubicin affects liver and intrahepatic bile duct neoplasm,1836,"The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.","Is the triple ""Doxorubicin affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.""?",False, -15592048,Doxorubicin affects diffuse large B-cell lymphoma,1837,"Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.","Is the triple ""Doxorubicin affects diffuse large B-cell lymphoma"" supported by the sentence: ""Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.""?",False, -15335028,Doxorubicin affects pancreatic ductal adenocarcinoma,1838,"We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.","Is the triple ""Doxorubicin affects pancreatic ductal adenocarcinoma"" supported by the sentence: ""We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.""?",False, -15288278,Doxorubicin affects mantle cell lymphoma,1839,"Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.","Is the triple ""Doxorubicin affects mantle cell lymphoma"" supported by the sentence: ""Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.""?",False, -15233880,Doxorubicin affects prostate cancer,1840,"In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.","Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.""?",False, -14862593,Doxorubicin affects liposarcoma,1841,"We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.","Is the triple ""Doxorubicin affects liposarcoma"" supported by the sentence: ""We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.""?",False, -13717435,Doxorubicin affects prostate cancer,1842,CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.,"Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.""?",False, -13641465,Doxorubicin affects Ewing sarcoma,1843,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects Ewing sarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, -13641464,Doxorubicin affects bone osteosarcoma,1844,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects bone osteosarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, -13477582,Doxorubicin affects hepatocellular carcinoma,1845,Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.,"Is the triple ""Doxorubicin affects hepatocellular carcinoma"" supported by the sentence: ""Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.""?",False, -12593977,Doxorubicin affects Kaposi's sarcoma,1846,Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.,"Is the triple ""Doxorubicin affects Kaposi's sarcoma"" supported by the sentence: ""Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.""?",False, -12038917,Doxorubicin affects acute lymphoblastic leukemia,1847,Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.,"Is the triple ""Doxorubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.""?",False, -11963770,Doxorubicin affects angiosarcoma,1848,DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.,"Is the triple ""Doxorubicin affects angiosarcoma"" supported by the sentence: ""DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.""?",False, -11068243,Doxorubicin affects neutropenia,1849,"Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.","Is the triple ""Doxorubicin affects neutropenia"" supported by the sentence: ""Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.""?",False, -9029101,Doxorubicin affects neoplasm,1850,"Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.""?",False, -7957058,Doxorubicin affects neoplasm,1851,"In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.""?",False, -7468708,Doxorubicin affects carcinoma,1852,Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.,"Is the triple ""Doxorubicin affects carcinoma"" supported by the sentence: ""Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.""?",False, -7221748,Doxorubicin affects small cell lung carcinoma,1853,"Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.","Is the triple ""Doxorubicin affects small cell lung carcinoma"" supported by the sentence: ""Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.""?",False, -22415368,Doxorubicin disrupts glioma,1854,"In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.","Is the triple ""Doxorubicin disrupts glioma"" supported by the sentence: ""In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.""?",False, -21775806,Doxorubicin disrupts non-small cell lung carcinoma,1855,Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.,"Is the triple ""Doxorubicin disrupts non-small cell lung carcinoma"" supported by the sentence: ""Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.""?",False, -19908932,Doxorubicin disrupts hematopoietic and lymphoid system neoplasm,1856,Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.,"Is the triple ""Doxorubicin disrupts hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.""?",False, -19216444,Doxorubicin disrupts lymphoma,1857,Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.,"Is the triple ""Doxorubicin disrupts lymphoma"" supported by the sentence: ""Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.""?",False, -18593046,Doxorubicin disrupts bone osteosarcoma,1858,"A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.","Is the triple ""Doxorubicin disrupts bone osteosarcoma"" supported by the sentence: ""A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.""?",False, -17338969,Doxorubicin disrupts melanoma,1859,In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).,"Is the triple ""Doxorubicin disrupts melanoma"" supported by the sentence: ""In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).""?",False, -15233882,Doxorubicin disrupts prostate cancer,1860,"In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.","Is the triple ""Doxorubicin disrupts prostate cancer"" supported by the sentence: ""In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.""?",False, -15026936,Doxorubicin disrupts B-cell neoplasm,1861,"RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.","Is the triple ""Doxorubicin disrupts B-cell neoplasm"" supported by the sentence: ""RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.""?",False, -14123664,Doxorubicin disrupts hepatocellular carcinoma,1862,CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.,"Is the triple ""Doxorubicin disrupts hepatocellular carcinoma"" supported by the sentence: ""CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.""?",False, -11529496,Doxorubicin disrupts neuroblastoma,1863,"We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.","Is the triple ""Doxorubicin disrupts neuroblastoma"" supported by the sentence: ""We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.""?",False, -8800155,Doxorubicin disrupts neoplasm,1864,"Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).","Is the triple ""Doxorubicin disrupts neoplasm"" supported by the sentence: ""Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).""?",False, -8316270,Doxorubicin disrupts Neoplasm Metastasis,1865,"However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.","Is the triple ""Doxorubicin disrupts Neoplasm Metastasis"" supported by the sentence: ""However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.""?",False, -24403937,Doxorubicin prevents triple-negative breast carcinoma,1866,"Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.","Is the triple ""Doxorubicin prevents triple-negative breast carcinoma"" supported by the sentence: ""Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.""?",False, -23195923,Doxorubicin prevents lung neoplasm,1867,In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.,"Is the triple ""Doxorubicin prevents lung neoplasm"" supported by the sentence: ""In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.""?",False, -22365593,Doxorubicin prevents leukemia,1868,"Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.","Is the triple ""Doxorubicin prevents leukemia"" supported by the sentence: ""Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.""?",False, -15227703,Doxorubicin prevents sarcoma,1869,"In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.","Is the triple ""Doxorubicin prevents sarcoma"" supported by the sentence: ""In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.""?",False, -10708896,Doxorubicin prevents urinary bladder neoplasm,1870,"CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.","Is the triple ""Doxorubicin prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.""?",False, -8872024,Doxorubicin prevents Neoplasm Metastasis,1871,"Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.","Is the triple ""Doxorubicin prevents Neoplasm Metastasis"" supported by the sentence: ""Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.""?",False, -8737011,Doxorubicin prevents neutropenia,1872,"CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.","Is the triple ""Doxorubicin prevents neutropenia"" supported by the sentence: ""CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.""?",False, -7721507,Doxorubicin prevents neoplasm,1873,"(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.","Is the triple ""Doxorubicin prevents neoplasm"" supported by the sentence: ""(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.""?",False, -18908502,Doxorubicin exacerbates neoplasm,1874,"Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.","Is the triple ""Doxorubicin exacerbates neoplasm"" supported by the sentence: ""Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.""?",False, -25000938,Doxorubicin predisposes bone osteosarcoma,1875,"CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.","Is the triple ""Doxorubicin predisposes bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.""?",False, -20426915,Doxorubicin predisposes neoplasm,1876,Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.,"Is the triple ""Doxorubicin predisposes neoplasm"" supported by the sentence: ""Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.""?",False, -19669792,Doxorubicin predisposes sarcoma,1877,"Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.","Is the triple ""Doxorubicin predisposes sarcoma"" supported by the sentence: ""Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.""?",False, -18137816,Doxorubicin predisposes lymphoma,1878,"Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.","Is the triple ""Doxorubicin predisposes lymphoma"" supported by the sentence: ""Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.""?",False, -12722667,Doxorubicin predisposes acute myeloid leukemia,1879,"Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.","Is the triple ""Doxorubicin predisposes acute myeloid leukemia"" supported by the sentence: ""Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.""?",False, -8803332,Doxorubicin predisposes kidney Wilms tumor,1880,CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.,"Is the triple ""Doxorubicin predisposes kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.""?",False, -7173827,Doxorubicin predisposes leukemia,1881,"CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.","Is the triple ""Doxorubicin predisposes leukemia"" supported by the sentence: ""CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.""?",False, -26966260,Iproniazid related to Monoamine Oxidase,1882,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, -26966260,Iproniazid related to Monoamine Oxidase,1883,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, -10565399,Iproniazid physically interacts with Monoamine Oxidase,1884,The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.,"Is the triple ""Iproniazid physically interacts with Monoamine Oxidase"" supported by the sentence: ""The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.""?",False, -12902070,Iproniazid affects depressive disorder,1885,"Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.","Is the triple ""Iproniazid affects depressive disorder"" supported by the sentence: ""Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.""?",False, -9833655,Iproniazid affects Monoamine Oxidase,1886,"The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.","Is the triple ""Iproniazid affects Monoamine Oxidase"" supported by the sentence: ""The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.""?",False, -10498318,Epirubicin related to non-small cell lung carcinoma,1887,Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.,"Is the triple ""Epirubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.""?",False, -10228088,Epirubicin related to ovarian cancer,1888,Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.,"Is the triple ""Epirubicin related to ovarian cancer"" supported by the sentence: ""Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.""?",False, -10182077,Epirubicin related to non-Hodgkin lymphoma,1889,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, -10182076,Epirubicin related to Hodgkins lymphoma,1890,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to Hodgkins lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, -8413603,Epirubicin related to small cell lung carcinoma,1891,"Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.","Is the triple ""Epirubicin related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.""?",False, -7746533,Epirubicin related to castration-resistant prostate carcinoma,1892,"The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.","Is the triple ""Epirubicin related to castration-resistant prostate carcinoma"" supported by the sentence: ""The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.""?",False, -26737878,Epirubicin physically interacts with 7-Deoxydoxorubicinone,1893,"In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.","Is the triple ""Epirubicin physically interacts with 7-Deoxydoxorubicinone"" supported by the sentence: ""In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.""?",False, -18781215,Epirubicin causes neoplasm,1894,"In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.","Is the triple ""Epirubicin causes neoplasm"" supported by the sentence: ""In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.""?",False, -26736958,Epirubicin affects hepatocellular carcinoma,1895,"Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.","Is the triple ""Epirubicin affects hepatocellular carcinoma"" supported by the sentence: ""Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.""?",False, -12104701,Epirubicin affects neoplasm,1896,RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.,"Is the triple ""Epirubicin affects neoplasm"" supported by the sentence: ""RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.""?",False, -14784473,Epirubicin prevents neoplasm,1897,"The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.","Is the triple ""Epirubicin prevents neoplasm"" supported by the sentence: ""The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.""?",False, -10544897,Nialamide physically interacts with Monoamine Oxidase,1898,"The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.","Is the triple ""Nialamide physically interacts with Monoamine Oxidase"" supported by the sentence: ""The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.""?",False, -9388429,Nialamide affects Monoamine Oxidase,1899,"Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.","Is the triple ""Nialamide affects Monoamine Oxidase"" supported by the sentence: ""Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.""?",False, -10646811,Isocarboxazid affects Monoamine Oxidase,1900,Monoamine oxidase inhibition by isocarboxazid.,"Is the triple ""Isocarboxazid affects Monoamine Oxidase"" supported by the sentence: ""Monoamine oxidase inhibition by isocarboxazid.""?",False, -14451724,Valacyclovir causes psychotic disorder,1901,"Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.","Is the triple ""Valacyclovir causes psychotic disorder"" supported by the sentence: ""Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.""?",False, -27205274,Valacyclovir affects postherpetic neuralgia,1902,"The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.","Is the triple ""Valacyclovir affects postherpetic neuralgia"" supported by the sentence: ""The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.""?",False, -25557382,Valacyclovir affects Pregnancy,1903,"METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).","Is the triple ""Valacyclovir affects Pregnancy"" supported by the sentence: ""METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).""?",False, -19384061,Valacyclovir disrupts herpes simplex infectious disease,1904,Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.,"Is the triple ""Valacyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.""?",False, -14963245,Valacyclovir disrupts herpes zoster,1905,VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.,"Is the triple ""Valacyclovir disrupts herpes zoster"" supported by the sentence: ""VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.""?",False, -10778326,Valacyclovir disrupts viral infectious disease,1906,"To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.","Is the triple ""Valacyclovir disrupts viral infectious disease"" supported by the sentence: ""To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.""?",False, -10108851,Valacyclovir disrupts herpes labialis,1907,The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.,"Is the triple ""Valacyclovir disrupts herpes labialis"" supported by the sentence: ""The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.""?",False, -8112054,Valacyclovir disrupts genital herpes,1908,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Valacyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, -19368060,Valacyclovir prevents postherpetic neuralgia,1909,FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.,"Is the triple ""Valacyclovir prevents postherpetic neuralgia"" supported by the sentence: ""FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.""?",False, -12346968,Valacyclovir prevents genital herpes,1910,Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.,"Is the triple ""Valacyclovir prevents genital herpes"" supported by the sentence: ""Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.""?",False, -10108849,Valacyclovir prevents herpes labialis,1911,"Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.","Is the triple ""Valacyclovir prevents herpes labialis"" supported by the sentence: ""Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.""?",False, -9970234,Valacyclovir prevents herpes simplex infectious disease,1912,Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.,"Is the triple ""Valacyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.""?",False, -8018684,Valacyclovir prevents cytomegalovirus infection,1913,The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.,"Is the triple ""Valacyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.""?",False, -8899981,Cidofovir affects cytomegalovirus retinitis,1914,The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.,"Is the triple ""Cidofovir affects cytomegalovirus retinitis"" supported by the sentence: ""The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.""?",False, -7346321,Cidofovir affects viral infectious disease,1915,The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.,"Is the triple ""Cidofovir affects viral infectious disease"" supported by the sentence: ""The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.""?",False, -11567412,Cidofovir disrupts cytomegalovirus infection,1916,These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.,"Is the triple ""Cidofovir disrupts cytomegalovirus infection"" supported by the sentence: ""These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.""?",False, -27502123,Cidofovir prevents herpes simplex infectious disease,1917,Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.,"Is the triple ""Cidofovir prevents herpes simplex infectious disease"" supported by the sentence: ""Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.""?",False, -16212718,Cidofovir prevents cytomegalovirus infection,1918,"* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.","Is the triple ""Cidofovir prevents cytomegalovirus infection"" supported by the sentence: ""* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.""?",False, -11248462,Cidofovir prevents viral infectious disease,1919,"Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.","Is the triple ""Cidofovir prevents viral infectious disease"" supported by the sentence: ""Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.""?",False, -26922185,Penciclovir affects viral infectious disease,1920,"Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.","Is the triple ""Penciclovir affects viral infectious disease"" supported by the sentence: ""Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.""?",False, -22087736,Valganciclovir affects cytomegalovirus infection,1921,The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.,"Is the triple ""Valganciclovir affects cytomegalovirus infection"" supported by the sentence: ""The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.""?",False, -18756429,Valganciclovir affects sensorineural hearing loss disorder,1922,IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.,"Is the triple ""Valganciclovir affects sensorineural hearing loss disorder"" supported by the sentence: ""IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.""?",False, -20121657,Valganciclovir disrupts cytomegalovirus infection,1923,"CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.","Is the triple ""Valganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.""?",False, -12085189,Valganciclovir prevents sensorineural hearing loss disorder,1924,"We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.","Is the triple ""Valganciclovir prevents sensorineural hearing loss disorder"" supported by the sentence: ""We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.""?",False, -11282399,Valganciclovir prevents cytomegalovirus infection,1925,"These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.","Is the triple ""Valganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.""?",False, -23156448,Valganciclovir predisposes kidney disorder,1926,"CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?","Is the triple ""Valganciclovir predisposes kidney disorder"" supported by the sentence: ""CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?""?",False, -20121656,Valganciclovir predisposes cytomegalovirus infection,1927,Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.,"Is the triple ""Valganciclovir predisposes cytomegalovirus infection"" supported by the sentence: ""Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.""?",False, -24607675,Remdesivir prevents adult acute respiratory distress syndrome,1928,Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.,"Is the triple ""Remdesivir prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.""?",False, -18302878,Pixantrone related to Deoxyribonucleic acid,1929,"The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.","Is the triple ""Pixantrone related to Deoxyribonucleic acid"" supported by the sentence: ""The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.""?",False, -19964229,Amrubicin affects small cell lung carcinoma,1930,"However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.","Is the triple ""Amrubicin affects small cell lung carcinoma"" supported by the sentence: ""However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.""?",False, -15413207,Amrubicin disrupts neoplasm,1931,"Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.","Is the triple ""Amrubicin disrupts neoplasm"" supported by the sentence: ""Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.""?",False, -16523835,Sevoflurane related to delirium,1932,"Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.","Is the triple ""Sevoflurane related to delirium"" supported by the sentence: ""Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.""?",False, -24969850,Sevoflurane causes adult acute respiratory distress syndrome,1933,This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.,"Is the triple ""Sevoflurane causes adult acute respiratory distress syndrome"" supported by the sentence: ""This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.""?",False, -24682900,Sevoflurane causes acute kidney failure,1934,The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.,"Is the triple ""Sevoflurane causes acute kidney failure"" supported by the sentence: ""The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.""?",False, -18232524,Sevoflurane causes Inflammation,1935,"The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.","Is the triple ""Sevoflurane causes Inflammation"" supported by the sentence: ""The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.""?",False, -17508909,Sevoflurane causes brain injury,1936,These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.,"Is the triple ""Sevoflurane causes brain injury"" supported by the sentence: ""These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.""?",False, -17459839,Sevoflurane causes ischemia reperfusion injury,1937,"BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).","Is the triple ""Sevoflurane causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).""?",False, -11419059,Sevoflurane causes delirium,1938,"Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.","Is the triple ""Sevoflurane causes delirium"" supported by the sentence: ""Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.""?",False, -7326848,Sevoflurane causes Pain,1939,"Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.","Is the triple ""Sevoflurane causes Pain"" supported by the sentence: ""Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.""?",False, -25308865,Sevoflurane affects neoplasm,1940,"Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.","Is the triple ""Sevoflurane affects neoplasm"" supported by the sentence: ""Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.""?",False, -25006055,Sevoflurane affects Pain,1941,Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.,"Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.""?",False, -21710900,Sevoflurane affects obesity disorder,1942,"To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.","Is the triple ""Sevoflurane affects obesity disorder"" supported by the sentence: ""To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.""?",False, -18602416,Sevoflurane affects delirium,1943,The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.,"Is the triple ""Sevoflurane affects delirium"" supported by the sentence: ""The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.""?",False, -17685948,Sevoflurane affects Pain,1944,"Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.","Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.""?",False, -17508906,Sevoflurane affects brain injury,1945,We investigated the effects of sevoflurane on EMP-induced brain injury.,"Is the triple ""Sevoflurane affects brain injury"" supported by the sentence: ""We investigated the effects of sevoflurane on EMP-induced brain injury.""?",False, -13563816,Sevoflurane affects Inflammation,1946,The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.,"Is the triple ""Sevoflurane affects Inflammation"" supported by the sentence: ""The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.""?",False, -7303814,Sevoflurane affects ischemia reperfusion injury,1947,"Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.","Is the triple ""Sevoflurane affects ischemia reperfusion injury"" supported by the sentence: ""Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.""?",False, -22571416,Sevoflurane disrupts myocardial infarction,1948,RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.,"Is the triple ""Sevoflurane disrupts myocardial infarction"" supported by the sentence: ""RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.""?",False, -22138617,Sevoflurane disrupts brain injury,1949,These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.,"Is the triple ""Sevoflurane disrupts brain injury"" supported by the sentence: ""These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.""?",False, -19949689,Sevoflurane disrupts ischemia reperfusion injury,1950,"New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.","Is the triple ""Sevoflurane disrupts ischemia reperfusion injury"" supported by the sentence: ""New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.""?",False, -17977822,Sevoflurane disrupts Inflammation,1951,Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.,"Is the triple ""Sevoflurane disrupts Inflammation"" supported by the sentence: ""Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.""?",False, -24348187,Sevoflurane prevents acute kidney failure,1952,Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.,"Is the triple ""Sevoflurane prevents acute kidney failure"" supported by the sentence: ""Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.""?",False, -24204877,Sevoflurane prevents neoplasm,1953,"BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.","Is the triple ""Sevoflurane prevents neoplasm"" supported by the sentence: ""BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.""?",False, -20028749,Sevoflurane prevents delirium,1954,Sevoflurane might be beneficial for reducing delirium and POCD.,"Is the triple ""Sevoflurane prevents delirium"" supported by the sentence: ""Sevoflurane might be beneficial for reducing delirium and POCD.""?",False, -19290567,Sevoflurane prevents Pain,1955,"CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.","Is the triple ""Sevoflurane prevents Pain"" supported by the sentence: ""CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.""?",False, -16830216,Sevoflurane prevents Inflammation,1956,This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.,"Is the triple ""Sevoflurane prevents Inflammation"" supported by the sentence: ""This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.""?",False, -11671117,Sevoflurane prevents brain injury,1957,Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.,"Is the triple ""Sevoflurane prevents brain injury"" supported by the sentence: ""Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.""?",False, -9664903,Sevoflurane prevents ischemia reperfusion injury,1958,BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.,"Is the triple ""Sevoflurane prevents ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.""?",False, -18320093,Sevoflurane predisposes delirium,1959,"Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.","Is the triple ""Sevoflurane predisposes delirium"" supported by the sentence: ""Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.""?",False, -18121347,Sevoflurane predisposes Inflammation,1960,Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.,"Is the triple ""Sevoflurane predisposes Inflammation"" supported by the sentence: ""Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.""?",False, -24455592,Desflurane causes Postoperative Complications,1961,Desflurane resulted in fewer postoperative complications.,"Is the triple ""Desflurane causes Postoperative Complications"" supported by the sentence: ""Desflurane resulted in fewer postoperative complications.""?",False, -16095968,Heroin related to heroin dependence,1962,The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.,"Is the triple ""Heroin related to heroin dependence"" supported by the sentence: ""The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.""?",False, -9440915,Heroin related to opiate dependence,1963,"This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.","Is the triple ""Heroin related to opiate dependence"" supported by the sentence: ""This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.""?",False, -18531996,Heroin causes heroin dependence,1964,"Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.","Is the triple ""Heroin causes heroin dependence"" supported by the sentence: ""Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.""?",False, -14784390,Heroin causes opiate dependence,1965,A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.,"Is the triple ""Heroin causes opiate dependence"" supported by the sentence: ""A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.""?",False, -19449218,Aluminum hydroxide related to type 1 diabetes mellitus,1966,Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.,"Is the triple ""Aluminum hydroxide related to type 1 diabetes mellitus"" supported by the sentence: ""Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.""?",False, -19135529,Aluminum hydroxide related to malaria,1967,METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.,"Is the triple ""Aluminum hydroxide related to malaria"" supported by the sentence: ""METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.""?",False, -18758930,Aluminum hydroxide related to influenza,1968,Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.,"Is the triple ""Aluminum hydroxide related to influenza"" supported by the sentence: ""Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.""?",False, -15398111,Aluminum hydroxide prevents stomatitis,1969,This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).,"Is the triple ""Aluminum hydroxide prevents stomatitis"" supported by the sentence: ""This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).""?",False, -15812884,Methadone related to heroin dependence,1970,Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.,"Is the triple ""Methadone related to heroin dependence"" supported by the sentence: ""Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.""?",False, -19260564,Methadone causes neonatal abstinence syndrome,1971,"Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.","Is the triple ""Methadone causes neonatal abstinence syndrome"" supported by the sentence: ""Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.""?",False, -18130331,Methadone causes neuralgia,1972,We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.,"Is the triple ""Methadone causes neuralgia"" supported by the sentence: ""We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.""?",False, -18100345,Methadone causes Pain,1973,Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.,"Is the triple ""Methadone causes Pain"" supported by the sentence: ""Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.""?",False, -21405277,Methadone affects opiate dependence,1974,"Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).","Is the triple ""Methadone affects opiate dependence"" supported by the sentence: ""Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).""?",False, -21075382,Methadone affects neoplasm,1975,The analgesic drug methadone is able to sensitize various tumors to chemotherapy.,"Is the triple ""Methadone affects neoplasm"" supported by the sentence: ""The analgesic drug methadone is able to sensitize various tumors to chemotherapy.""?",False, -20010980,Methadone affects Premature birth,1976,They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.,"Is the triple ""Methadone affects Premature birth"" supported by the sentence: ""They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.""?",False, -18302283,Methadone affects Pain,1977,"There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.","Is the triple ""Methadone affects Pain"" supported by the sentence: ""There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.""?",False, -18207522,Methadone affects neonatal abstinence syndrome,1978,"The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.","Is the triple ""Methadone affects neonatal abstinence syndrome"" supported by the sentence: ""The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.""?",False, -18078354,Methadone affects cocaine dependence,1979,"Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.","Is the triple ""Methadone affects cocaine dependence"" supported by the sentence: ""Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.""?",False, -11558529,Methadone affects HIV infectious disease,1980,"OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.","Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.""?",False, -9289228,Methadone affects HIV infectious disease,1981,Methadone enhances human immunodeficiency virus infection of human immune cells.,"Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""Methadone enhances human immunodeficiency virus infection of human immune cells.""?",False, -8979183,Methadone affects neuralgia,1982,Studies are on going to assess the potential role of methadone in treating neuropathic pain.,"Is the triple ""Methadone affects neuralgia"" supported by the sentence: ""Studies are on going to assess the potential role of methadone in treating neuropathic pain.""?",False, -16059875,Methadone disrupts neonatal abstinence syndrome,1983,"Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.","Is the triple ""Methadone disrupts neonatal abstinence syndrome"" supported by the sentence: ""Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.""?",False, -10769844,Methadone disrupts Pain,1984,"However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.","Is the triple ""Methadone disrupts Pain"" supported by the sentence: ""However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.""?",False, -17766557,Methadone prevents hepatitis C virus infection,1985,There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.,"Is the triple ""Methadone prevents hepatitis C virus infection"" supported by the sentence: ""There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.""?",False, -15264750,Methadone prevents opiate dependence,1986,Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.,"Is the triple ""Methadone prevents opiate dependence"" supported by the sentence: ""Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.""?",False, -8905283,Methadone prevents Pain,1987,"In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.","Is the triple ""Methadone prevents Pain"" supported by the sentence: ""In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.""?",False, -8022918,Methadone prevents neonatal abstinence syndrome,1988,Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.,"Is the triple ""Methadone prevents neonatal abstinence syndrome"" supported by the sentence: ""Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.""?",False, -26487110,Methadone predisposes HIV infectious disease,1989,"A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.","Is the triple ""Methadone predisposes HIV infectious disease"" supported by the sentence: ""A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.""?",False, -15424591,Methadone predisposes neonatal abstinence syndrome,1990,CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.,"Is the triple ""Methadone predisposes neonatal abstinence syndrome"" supported by the sentence: ""CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.""?",False, -14491460,Methadone predisposes Premature birth,1991,"CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.","Is the triple ""Methadone predisposes Premature birth"" supported by the sentence: ""CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.""?",False, -26386166,Levomethadyl acetate causes opiate dependence,1992,"Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.","Is the triple ""Levomethadyl acetate causes opiate dependence"" supported by the sentence: ""Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.""?",False, -26901861,Halofantrine prevents malaria,1993,Postexposure administration of halofantrine for the prevention of malaria.,"Is the triple ""Halofantrine prevents malaria"" supported by the sentence: ""Postexposure administration of halofantrine for the prevention of malaria.""?",False, -27668107,Erythropoietin related to HIV infectious disease,1994,"Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.","Is the triple ""Erythropoietin related to HIV infectious disease"" supported by the sentence: ""Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.""?",False, -24695634,Erythropoietin related to optic nerve disorder,1995,Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.,"Is the triple ""Erythropoietin related to optic nerve disorder"" supported by the sentence: ""Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.""?",False, -21186290,Erythropoietin related to Premature birth,1996,"To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.","Is the triple ""Erythropoietin related to Premature birth"" supported by the sentence: ""To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.""?",False, -20871066,Erythropoietin related to necrotizing enterocolitis,1997,"The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.","Is the triple ""Erythropoietin related to necrotizing enterocolitis"" supported by the sentence: ""The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.""?",False, -18130124,Erythropoietin related to mood disorder,1998,Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.,"Is the triple ""Erythropoietin related to mood disorder"" supported by the sentence: ""Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.""?",False, -17186873,Erythropoietin related to ST-elevation myocardial infarction,1999,High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.,"Is the triple ""Erythropoietin related to ST-elevation myocardial infarction"" supported by the sentence: ""High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.""?",False, -16980950,Erythropoietin related to acute myeloid leukemia,2000,The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.,"Is the triple ""Erythropoietin related to acute myeloid leukemia"" supported by the sentence: ""The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.""?",False, -16468663,Erythropoietin related to optic neuritis,2001,"A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.","Is the triple ""Erythropoietin related to optic neuritis"" supported by the sentence: ""A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.""?",False, -16173384,Erythropoietin related to Friedreich ataxia,2002,Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.,"Is the triple ""Erythropoietin related to Friedreich ataxia"" supported by the sentence: ""Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.""?",False, -15054484,Erythropoietin related to breast neoplasm,2003,"EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.","Is the triple ""Erythropoietin related to breast neoplasm"" supported by the sentence: ""EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.""?",False, -14004775,Erythropoietin related to malaria,2004,"To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.","Is the triple ""Erythropoietin related to malaria"" supported by the sentence: ""To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.""?",False, -13955435,Erythropoietin related to chronic renal failure syndrome,2005,[Erythropoietin in the treatment of anemia in chronic renal insufficiency].,"Is the triple ""Erythropoietin related to chronic renal failure syndrome"" supported by the sentence: ""[Erythropoietin in the treatment of anemia in chronic renal insufficiency].""?",False, -13624052,Erythropoietin related to stroke disorder,2006,"Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.","Is the triple ""Erythropoietin related to stroke disorder"" supported by the sentence: ""Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.""?",False, -13580694,Erythropoietin related to Fatigue,2007,Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).,"Is the triple ""Erythropoietin related to Fatigue"" supported by the sentence: ""Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).""?",False, -13206114,Erythropoietin related to sickle cell anemia,2008,Erythropoietin for anemia of renal failure in sickle cell disease.,"Is the triple ""Erythropoietin related to sickle cell anemia"" supported by the sentence: ""Erythropoietin for anemia of renal failure in sickle cell disease.""?",False, -12496787,Erythropoietin related to subarachnoid hemorrhage,2009,Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.,"Is the triple ""Erythropoietin related to subarachnoid hemorrhage"" supported by the sentence: ""Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.""?",False, -12188394,Erythropoietin related to Parkinson disease,2010,"These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.","Is the triple ""Erythropoietin related to Parkinson disease"" supported by the sentence: ""These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.""?",False, -12126135,Erythropoietin related to spinal cord injury,2011,We determined whether EPO and MPSS act synergistically in SCI.,"Is the triple ""Erythropoietin related to spinal cord injury"" supported by the sentence: ""We determined whether EPO and MPSS act synergistically in SCI.""?",False, -11923140,Erythropoietin related to acute kidney failure,2012,Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.,"Is the triple ""Erythropoietin related to acute kidney failure"" supported by the sentence: ""Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.""?",False, -11799479,Erythropoietin related to myocardial infarction,2013,A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.,"Is the triple ""Erythropoietin related to myocardial infarction"" supported by the sentence: ""A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.""?",False, -11734187,Erythropoietin related to multiple sclerosis,2014,Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.,"Is the triple ""Erythropoietin related to multiple sclerosis"" supported by the sentence: ""Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.""?",False, -11580074,Erythropoietin related to ischemia reperfusion injury,2015,We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.,"Is the triple ""Erythropoietin related to ischemia reperfusion injury"" supported by the sentence: ""We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.""?",False, -11529882,Erythropoietin related to myocardial ischemia,2016,"To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.","Is the triple ""Erythropoietin related to myocardial ischemia"" supported by the sentence: ""To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.""?",False, -11452051,Erythropoietin related to prostate cancer,2017,These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.,"Is the triple ""Erythropoietin related to prostate cancer"" supported by the sentence: ""These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.""?",False, -11316441,Erythropoietin related to Ischemic stroke,2018,The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.,"Is the triple ""Erythropoietin related to Ischemic stroke"" supported by the sentence: ""The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.""?",False, -11293850,Erythropoietin related to amyotrophic lateral sclerosis,2019,"Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.","Is the triple ""Erythropoietin related to amyotrophic lateral sclerosis"" supported by the sentence: ""Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.""?",False, -10879812,Erythropoietin related to hepatitis C virus infection,2020,Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.,"Is the triple ""Erythropoietin related to hepatitis C virus infection"" supported by the sentence: ""Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.""?",False, -10348029,Erythropoietin related to neoplasm,2021,We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.,"Is the triple ""Erythropoietin related to neoplasm"" supported by the sentence: ""We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.""?",False, -9392178,Erythropoietin related to injury,2022,Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.,"Is the triple ""Erythropoietin related to injury"" supported by the sentence: ""Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.""?",False, -9089666,Erythropoietin related to chronic myelomonocytic leukemia,2023,Response to erythropoietin in chronic myelomonocytic leukaemia.,"Is the triple ""Erythropoietin related to chronic myelomonocytic leukemia"" supported by the sentence: ""Response to erythropoietin in chronic myelomonocytic leukaemia.""?",False, -8164061,Erythropoietin related to myelodysplastic syndrome,2024,"We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.","Is the triple ""Erythropoietin related to myelodysplastic syndrome"" supported by the sentence: ""We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.""?",False, -7458321,Erythropoietin related to brain ischemia,2025,A potential role for erythropoietin in focal permanent cerebral ischemia in mice.,"Is the triple ""Erythropoietin related to brain ischemia"" supported by the sentence: ""A potential role for erythropoietin in focal permanent cerebral ischemia in mice.""?",False, -7310369,Erythropoietin related to anemia,2026,"The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.","Is the triple ""Erythropoietin related to anemia"" supported by the sentence: ""The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.""?",False, -7231907,Erythropoietin related to chronic kidney disease,2027,Drug usage evaluation of epoetin in chronic renal failure.,"Is the triple ""Erythropoietin related to chronic kidney disease"" supported by the sentence: ""Drug usage evaluation of epoetin in chronic renal failure.""?",False, -7137476,Erythropoietin related to kidney failure,2028,This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.,"Is the triple ""Erythropoietin related to kidney failure"" supported by the sentence: ""This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.""?",False, -12479345,Erythropoietin has part myelodysplastic syndrome,2029,"An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.","Is the triple ""Erythropoietin has part myelodysplastic syndrome"" supported by the sentence: ""An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.""?",False, -9398172,Erythropoietin has part neoplasm,2030,"Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.","Is the triple ""Erythropoietin has part neoplasm"" supported by the sentence: ""Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.""?",False, -27259307,Erythropoietin causes acute kidney failure,2031,"To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.","Is the triple ""Erythropoietin causes acute kidney failure"" supported by the sentence: ""To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.""?",False, -20985522,Erythropoietin causes ischemia reperfusion injury,2032,"RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.","Is the triple ""Erythropoietin causes ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.""?",False, -19282478,Erythropoietin causes neoplasm,2033,"Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.","Is the triple ""Erythropoietin causes neoplasm"" supported by the sentence: ""Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.""?",False, -19178150,Erythropoietin causes spinal cord injury,2034,"AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.","Is the triple ""Erythropoietin causes spinal cord injury"" supported by the sentence: ""AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.""?",False, -18508111,Erythropoietin causes Parkinson disease,2035,"The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.","Is the triple ""Erythropoietin causes Parkinson disease"" supported by the sentence: ""The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.""?",False, -16355442,Erythropoietin causes brain ischemia,2036,"Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.","Is the triple ""Erythropoietin causes brain ischemia"" supported by the sentence: ""Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.""?",False, -15387266,Erythropoietin causes stroke disorder,2037,Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.,"Is the triple ""Erythropoietin causes stroke disorder"" supported by the sentence: ""Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.""?",False, -13935957,Erythropoietin causes injury,2038,OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.,"Is the triple ""Erythropoietin causes injury"" supported by the sentence: ""OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.""?",False, -12824447,Erythropoietin causes chronic kidney disease,2039,"BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.","Is the triple ""Erythropoietin causes chronic kidney disease"" supported by the sentence: ""BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.""?",False, -11912976,Erythropoietin causes myocardial infarction,2040,"Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).","Is the triple ""Erythropoietin causes myocardial infarction"" supported by the sentence: ""Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).""?",False, -11763164,Erythropoietin causes Fatigue,2041,"The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.","Is the triple ""Erythropoietin causes Fatigue"" supported by the sentence: ""The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.""?",False, -9672360,Erythropoietin causes kidney failure,2042,"Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.","Is the triple ""Erythropoietin causes kidney failure"" supported by the sentence: ""Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.""?",False, -9370139,Erythropoietin causes subarachnoid hemorrhage,2043,"A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).","Is the triple ""Erythropoietin causes subarachnoid hemorrhage"" supported by the sentence: ""A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).""?",False, -8009177,Erythropoietin causes anemia,2044,Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.,"Is the triple ""Erythropoietin causes anemia"" supported by the sentence: ""Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.""?",False, -26962810,Erythropoietin affects HIV infectious disease,2045,These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.,"Is the triple ""Erythropoietin affects HIV infectious disease"" supported by the sentence: ""These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.""?",False, -26278974,Erythropoietin affects sickle cell anemia,2046,These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.,"Is the triple ""Erythropoietin affects sickle cell anemia"" supported by the sentence: ""These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.""?",False, -24983690,Erythropoietin affects acute myeloid leukemia,2047,We conclude that both erythropoietin and BPA are appropriately increased in ANLL.,"Is the triple ""Erythropoietin affects acute myeloid leukemia"" supported by the sentence: ""We conclude that both erythropoietin and BPA are appropriately increased in ANLL.""?",False, -20885392,Erythropoietin affects ST-elevation myocardial infarction,2048,Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).,"Is the triple ""Erythropoietin affects ST-elevation myocardial infarction"" supported by the sentence: ""Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).""?",False, -20610677,Erythropoietin affects stroke disorder,2049,"In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.","Is the triple ""Erythropoietin affects stroke disorder"" supported by the sentence: ""In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.""?",False, -18390137,Erythropoietin affects chronic kidney disease,2050,The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.""?",False, -18352546,Erythropoietin affects injury,2051,Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.,"Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.""?",False, -17607901,Erythropoietin affects necrotizing enterocolitis,2052,The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.,"Is the triple ""Erythropoietin affects necrotizing enterocolitis"" supported by the sentence: ""The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.""?",False, -15862945,Erythropoietin affects Ischemic stroke,2053,"To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.","Is the triple ""Erythropoietin affects Ischemic stroke"" supported by the sentence: ""To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.""?",False, -15862785,Erythropoietin affects malaria,2054,"CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.","Is the triple ""Erythropoietin affects malaria"" supported by the sentence: ""CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.""?",False, -15728394,Erythropoietin affects myocardial infarction,2055,"Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.""?",False, -15532613,Erythropoietin affects myocardial infarction,2056,"Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.""?",False, -12937865,Erythropoietin affects anemia,2057,"CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.","Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.""?",False, -12867407,Erythropoietin affects myocardial ischemia,2058,Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.,"Is the triple ""Erythropoietin affects myocardial ischemia"" supported by the sentence: ""Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.""?",False, -11701568,Erythropoietin affects Fatigue,2059,"This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.","Is the triple ""Erythropoietin affects Fatigue"" supported by the sentence: ""This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.""?",False, -11563361,Erythropoietin affects neoplasm,2060,"Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.","Is the triple ""Erythropoietin affects neoplasm"" supported by the sentence: ""Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.""?",False, -10970912,Erythropoietin affects brain injury,2061,BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.,"Is the triple ""Erythropoietin affects brain injury"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.""?",False, -10068762,Erythropoietin affects injury,2062,"Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.","Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.""?",False, -9989127,Erythropoietin affects ischemia reperfusion injury,2063,OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.,"Is the triple ""Erythropoietin affects ischemia reperfusion injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.""?",False, -9392180,Erythropoietin affects spinal cord injury,2064,These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.,"Is the triple ""Erythropoietin affects spinal cord injury"" supported by the sentence: ""These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.""?",False, -8981317,Erythropoietin affects brain ischemia,2065,"When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.","Is the triple ""Erythropoietin affects brain ischemia"" supported by the sentence: ""When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.""?",False, -7400221,Erythropoietin affects chronic kidney disease,2066,Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.""?",False, -7278560,Erythropoietin affects anemia,2067,Erythropoietin elevation in anemia of thermal injury.,"Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""Erythropoietin elevation in anemia of thermal injury.""?",False, -27259305,Erythropoietin produces acute kidney failure,2068,Erythropoietin production in rats with post-ischemic acute renal failure.,"Is the triple ""Erythropoietin produces acute kidney failure"" supported by the sentence: ""Erythropoietin production in rats with post-ischemic acute renal failure.""?",False, -26811591,Erythropoietin produces HIV infectious disease,2069,The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.,"Is the triple ""Erythropoietin produces HIV infectious disease"" supported by the sentence: ""The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.""?",False, -26231858,Erythropoietin produces lymphoma,2070,Renal lymphosarcoma with inappropriate erythropoietin production in a dog.,"Is the triple ""Erythropoietin produces lymphoma"" supported by the sentence: ""Renal lymphosarcoma with inappropriate erythropoietin production in a dog.""?",False, -14673419,Erythropoietin produces myocardial infarction,2071,Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.,"Is the triple ""Erythropoietin produces myocardial infarction"" supported by the sentence: ""Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.""?",False, -11452049,Erythropoietin produces prostate cancer,2072,"To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.","Is the triple ""Erythropoietin produces prostate cancer"" supported by the sentence: ""To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.""?",False, -8829207,Erythropoietin produces neoplasm,2073,The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.,"Is the triple ""Erythropoietin produces neoplasm"" supported by the sentence: ""The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.""?",False, -8032421,Erythropoietin produces chronic renal failure syndrome,2074,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic renal failure syndrome"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, -8032418,Erythropoietin produces chronic kidney disease,2075,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic kidney disease"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, -7919214,Erythropoietin produces anemia,2076,"The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.","Is the triple ""Erythropoietin produces anemia"" supported by the sentence: ""The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.""?",False, -7844664,Erythropoietin produces kidney failure,2077,Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.,"Is the triple ""Erythropoietin produces kidney failure"" supported by the sentence: ""Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.""?",False, -17835656,Erythropoietin disrupts brain injury,2078,"CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.","Is the triple ""Erythropoietin disrupts brain injury"" supported by the sentence: ""CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.""?",False, -17602040,Erythropoietin disrupts Hemorrhage,2079,"CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.","Is the triple ""Erythropoietin disrupts Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.""?",False, -17384804,Erythropoietin disrupts Ischemic stroke,2080,"Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.","Is the triple ""Erythropoietin disrupts Ischemic stroke"" supported by the sentence: ""Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.""?",False, -15027834,Erythropoietin disrupts Fatigue,2081,"In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.","Is the triple ""Erythropoietin disrupts Fatigue"" supported by the sentence: ""In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.""?",False, -13243471,Erythropoietin disrupts chronic kidney disease,2082,"Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).","Is the triple ""Erythropoietin disrupts chronic kidney disease"" supported by the sentence: ""Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).""?",False, -13033535,Erythropoietin disrupts amyotrophic lateral sclerosis,2083,Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.,"Is the triple ""Erythropoietin disrupts amyotrophic lateral sclerosis"" supported by the sentence: ""Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.""?",False, -11253087,Erythropoietin disrupts injury,2084,"Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.","Is the triple ""Erythropoietin disrupts injury"" supported by the sentence: ""Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.""?",False, -8818732,Erythropoietin disrupts anemia,2085,"Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.","Is the triple ""Erythropoietin disrupts anemia"" supported by the sentence: ""Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.""?",False, -22124183,Erythropoietin prevents Premature birth,2086,Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.,"Is the triple ""Erythropoietin prevents Premature birth"" supported by the sentence: ""Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.""?",False, -19522952,Erythropoietin prevents Asphyxia,2087,OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.,"Is the triple ""Erythropoietin prevents Asphyxia"" supported by the sentence: ""OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.""?",False, -17246645,Erythropoietin prevents cerebral palsy,2088,"We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.","Is the triple ""Erythropoietin prevents cerebral palsy"" supported by the sentence: ""We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.""?",False, -16915551,Erythropoietin prevents coronary artery disorder,2089,"Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.","Is the triple ""Erythropoietin prevents coronary artery disorder"" supported by the sentence: ""Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.""?",False, -16468664,Erythropoietin prevents optic neuritis,2090,INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.,"Is the triple ""Erythropoietin prevents optic neuritis"" supported by the sentence: ""INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.""?",False, -16040441,Erythropoietin prevents spinal cord injury,2091,This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.,"Is the triple ""Erythropoietin prevents spinal cord injury"" supported by the sentence: ""This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.""?",False, -15444373,Erythropoietin prevents Parkinson disease,2092,"In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.","Is the triple ""Erythropoietin prevents Parkinson disease"" supported by the sentence: ""In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.""?",False, -14252439,Erythropoietin prevents kidney failure,2093,"The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.","Is the triple ""Erythropoietin prevents kidney failure"" supported by the sentence: ""The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.""?",False, -13347324,Erythropoietin prevents subarachnoid hemorrhage,2094,BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.,"Is the triple ""Erythropoietin prevents subarachnoid hemorrhage"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.""?",False, -13017739,Erythropoietin prevents chronic kidney disease,2095,[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].,"Is the triple ""Erythropoietin prevents chronic kidney disease"" supported by the sentence: ""[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].""?",False, -11480928,Erythropoietin prevents Ischemic stroke,2096,"Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.","Is the triple ""Erythropoietin prevents Ischemic stroke"" supported by the sentence: ""Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.""?",False, -11148609,Erythropoietin prevents myocardial ischemia,2097,"Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.","Is the triple ""Erythropoietin prevents myocardial ischemia"" supported by the sentence: ""Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.""?",False, -11115141,Erythropoietin prevents stroke disorder,2098,"Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.","Is the triple ""Erythropoietin prevents stroke disorder"" supported by the sentence: ""Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.""?",False, -10838253,Erythropoietin prevents necrotizing enterocolitis,2099,Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.,"Is the triple ""Erythropoietin prevents necrotizing enterocolitis"" supported by the sentence: ""Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.""?",False, -10766440,Erythropoietin prevents myocardial infarction,2100,Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.,"Is the triple ""Erythropoietin prevents myocardial infarction"" supported by the sentence: ""Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.""?",False, -10125087,Erythropoietin prevents ischemia reperfusion injury,2101,"HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.","Is the triple ""Erythropoietin prevents ischemia reperfusion injury"" supported by the sentence: ""HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.""?",False, -8434315,Erythropoietin prevents injury,2102,"In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.","Is the triple ""Erythropoietin prevents injury"" supported by the sentence: ""In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.""?",False, -8405867,Erythropoietin prevents brain ischemia,2103,Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.,"Is the triple ""Erythropoietin prevents brain ischemia"" supported by the sentence: ""Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.""?",False, -8369017,Erythropoietin prevents brain injury,2104,Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.,"Is the triple ""Erythropoietin prevents brain injury"" supported by the sentence: ""Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.""?",False, -7400218,Erythropoietin prevents Fatigue,2105,"Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.","Is the triple ""Erythropoietin prevents Fatigue"" supported by the sentence: ""Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.""?",False, -7236347,Erythropoietin prevents anemia,2106,"Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.","Is the triple ""Erythropoietin prevents anemia"" supported by the sentence: ""Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.""?",False, -18610239,Erythropoietin exacerbates injury,2107,"However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.","Is the triple ""Erythropoietin exacerbates injury"" supported by the sentence: ""However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.""?",False, -14126866,Erythropoietin exacerbates anemia,2108,"Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.","Is the triple ""Erythropoietin exacerbates anemia"" supported by the sentence: ""Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.""?",False, -25818939,Erythropoietin predisposes neoplasm,2109,"Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.","Is the triple ""Erythropoietin predisposes neoplasm"" supported by the sentence: ""Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.""?",False, -19869298,Erythropoietin predisposes coronary artery disorder,2110,CONCLUSION: Increased EPO and RDW might be risk factors for CAD.,"Is the triple ""Erythropoietin predisposes coronary artery disorder"" supported by the sentence: ""CONCLUSION: Increased EPO and RDW might be risk factors for CAD.""?",False, -19564296,Erythropoietin predisposes Asphyxia,2111,Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.,"Is the triple ""Erythropoietin predisposes Asphyxia"" supported by the sentence: ""Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.""?",False, -19270398,Erythropoietin predisposes brain injury,2112,"According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.","Is the triple ""Erythropoietin predisposes brain injury"" supported by the sentence: ""According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.""?",False, -18282528,Erythropoietin predisposes chronic kidney disease,2113,"Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.","Is the triple ""Erythropoietin predisposes chronic kidney disease"" supported by the sentence: ""Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.""?",False, -16056103,Erythropoietin predisposes Ischemic stroke,2114,CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.,"Is the triple ""Erythropoietin predisposes Ischemic stroke"" supported by the sentence: ""CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.""?",False, -14483144,Erythropoietin predisposes injury,2115,"METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.","Is the triple ""Erythropoietin predisposes injury"" supported by the sentence: ""METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.""?",False, -12166360,Erythropoietin predisposes kidney failure,2116,Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.,"Is the triple ""Erythropoietin predisposes kidney failure"" supported by the sentence: ""Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.""?",False, -8361116,Erythropoietin predisposes anemia,2117,"Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.","Is the triple ""Erythropoietin predisposes anemia"" supported by the sentence: ""Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.""?",False, -24327196,Daprodustat affects anemia,2118,METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.,"Is the triple ""Daprodustat affects anemia"" supported by the sentence: ""METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.""?",False, -24574810,Daprodustat prevents anemia,2119,Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.,"Is the triple ""Daprodustat prevents anemia"" supported by the sentence: ""Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.""?",False, -19595886,mecobalamin related to vitamin B12 deficiency,2120,Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?,"Is the triple ""mecobalamin related to vitamin B12 deficiency"" supported by the sentence: ""Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?""?",False, -13417310,mecobalamin related to amyotrophic lateral sclerosis,2121,[Clinical trials of ultra-high-dose methylcobalamin in ALS].,"Is the triple ""mecobalamin related to amyotrophic lateral sclerosis"" supported by the sentence: ""[Clinical trials of ultra-high-dose methylcobalamin in ALS].""?",False, -26391120,vitamin B12 related to myocardial infarction,2122,[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].,"Is the triple ""vitamin B12 related to myocardial infarction"" supported by the sentence: ""[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].""?",False, -21860699,vitamin B12 related to type 2 diabetes mellitus,2123,"Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.","Is the triple ""vitamin B12 related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.""?",False, -20662929,vitamin B12 related to non-small cell lung carcinoma,2124,CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.,"Is the triple ""vitamin B12 related to non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.""?",False, -19346996,vitamin B12 related to myocardial ischemia,2125,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""vitamin B12 related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, -12974621,vitamin B12 related to osteoporosis,2126,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""vitamin B12 related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, -10934739,vitamin B12 related to chronic kidney disease,2127,Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.,"Is the triple ""vitamin B12 related to chronic kidney disease"" supported by the sentence: ""Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.""?",False, -10883089,vitamin B12 related to depressive disorder,2128,BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.,"Is the triple ""vitamin B12 related to depressive disorder"" supported by the sentence: ""BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.""?",False, -10658870,vitamin B12 related to psoriasis,2129,Is vitamin B12 of value in psoriasis?,"Is the triple ""vitamin B12 related to psoriasis"" supported by the sentence: ""Is vitamin B12 of value in psoriasis?""?",False, -10535786,vitamin B12 related to atherosclerosis,2130,Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.,"Is the triple ""vitamin B12 related to atherosclerosis"" supported by the sentence: ""Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.""?",False, -10535188,vitamin B12 related to lymphoma,2131,Serum vitamin B12 in leukemias and malignant lymphomas.,"Is the triple ""vitamin B12 related to lymphoma"" supported by the sentence: ""Serum vitamin B12 in leukemias and malignant lymphomas.""?",False, -10508686,vitamin B12 related to vitamin B12 deficiency,2132,[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].,"Is the triple ""vitamin B12 related to vitamin B12 deficiency"" supported by the sentence: ""[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].""?",False, -10438501,vitamin B12 related to iron deficiency anemia,2133,Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.,"Is the triple ""vitamin B12 related to iron deficiency anemia"" supported by the sentence: ""Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.""?",False, -9977774,vitamin B12 related to psychotic disorder,2134,Letter: Vitamin B12 in late-onset psychosis of childhood.,"Is the triple ""vitamin B12 related to psychotic disorder"" supported by the sentence: ""Letter: Vitamin B12 in late-onset psychosis of childhood.""?",False, -9644935,vitamin B12 related to anemia,2135,"However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.","Is the triple ""vitamin B12 related to anemia"" supported by the sentence: ""However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.""?",False, -9118739,vitamin B12 related to Low back pain,2136,"Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.","Is the triple ""vitamin B12 related to Low back pain"" supported by the sentence: ""Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.""?",False, -8678107,vitamin B12 related to Alzheimer disease,2137,"Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.","Is the triple ""vitamin B12 related to Alzheimer disease"" supported by the sentence: ""Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.""?",False, -27330642,vitamin B12 causes depressive disorder,2138,"Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.","Is the triple ""vitamin B12 causes depressive disorder"" supported by the sentence: ""Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.""?",False, -26003936,vitamin B12 causes diabetic neuropathy,2139,Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?,"Is the triple ""vitamin B12 causes diabetic neuropathy"" supported by the sentence: ""Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?""?",False, -17687811,vitamin B12 causes osteoporosis,2140,"In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.","Is the triple ""vitamin B12 causes osteoporosis"" supported by the sentence: ""In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.""?",False, -11993792,vitamin B12 causes Reduced blood folate concentration,2141,RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.,"Is the triple ""vitamin B12 causes Reduced blood folate concentration"" supported by the sentence: ""RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.""?",False, -10806959,vitamin B12 causes psychotic disorder,2142,"Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.","Is the triple ""vitamin B12 causes psychotic disorder"" supported by the sentence: ""Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.""?",False, -10716413,vitamin B12 causes vitamin B12 deficiency,2143,[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].,"Is the triple ""vitamin B12 causes vitamin B12 deficiency"" supported by the sentence: ""[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].""?",False, -9828196,vitamin B12 causes anemia,2144,Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.,"Is the triple ""vitamin B12 causes anemia"" supported by the sentence: ""Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.""?",False, -7900732,vitamin B12 causes atherosclerosis,2145,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""vitamin B12 causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, -25091008,vitamin B12 affects HIV infectious disease,2146,"Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.","Is the triple ""vitamin B12 affects HIV infectious disease"" supported by the sentence: ""Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.""?",False, -20098295,vitamin B12 affects depressive disorder,2147,"At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.""?",False, -19763864,vitamin B12 affects Alzheimer disease,2148,"This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.","Is the triple ""vitamin B12 affects Alzheimer disease"" supported by the sentence: ""This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.""?",False, -18490813,vitamin B12 affects depressive disorder,2149,"In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.""?",False, -17348852,vitamin B12 affects vitamin B12 deficiency,2150,"Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.","Is the triple ""vitamin B12 affects vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.""?",False, -16930257,vitamin B12 affects amyotrophic lateral sclerosis,2151,"Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.","Is the triple ""vitamin B12 affects amyotrophic lateral sclerosis"" supported by the sentence: ""Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.""?",False, -13607058,vitamin B12 affects depressive disorder,2152,"Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.""?",False, -12773836,vitamin B12 affects atherosclerosis,2153,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""vitamin B12 affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, -11945900,vitamin B12 affects Pregnancy,2154,"RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.""?",False, -11927611,vitamin B12 affects diabetic neuropathy,2155,"However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.","Is the triple ""vitamin B12 affects diabetic neuropathy"" supported by the sentence: ""However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.""?",False, -10798681,vitamin B12 affects type 2 diabetes mellitus,2156,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""vitamin B12 affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, -10424959,vitamin B12 affects anemia,2157,[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].,"Is the triple ""vitamin B12 affects anemia"" supported by the sentence: ""[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].""?",False, -8733280,vitamin B12 affects Pregnancy,2158,"The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.""?",False, -8015838,vitamin B12 affects chronic kidney disease,2159,Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.,"Is the triple ""vitamin B12 affects chronic kidney disease"" supported by the sentence: ""Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.""?",False, -23636866,vitamin B12 produces vitamin B12 deficiency,2160,"Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.","Is the triple ""vitamin B12 produces vitamin B12 deficiency"" supported by the sentence: ""Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.""?",False, -11124683,vitamin B12 disrupts chronic kidney disease,2161,"CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.","Is the triple ""vitamin B12 disrupts chronic kidney disease"" supported by the sentence: ""CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.""?",False, -20603701,vitamin B12 prevents Alzheimer disease,2162,"Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.","Is the triple ""vitamin B12 prevents Alzheimer disease"" supported by the sentence: ""Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.""?",False, -14586818,vitamin B12 prevents anemia,2163,"The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.","Is the triple ""vitamin B12 prevents anemia"" supported by the sentence: ""The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.""?",False, -10782972,vitamin B12 prevents atherosclerosis,2164,"Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.","Is the triple ""vitamin B12 prevents atherosclerosis"" supported by the sentence: ""Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.""?",False, -9545669,vitamin B12 prevents vitamin B12 deficiency,2165,Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.,"Is the triple ""vitamin B12 prevents vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.""?",False, -27415421,vitamin B12 predisposes myocardial infarction,2166,"BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).","Is the triple ""vitamin B12 predisposes myocardial infarction"" supported by the sentence: ""BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).""?",False, -21063265,vitamin B12 predisposes depressive disorder,2167,Risk of depression in pregnant women with low-normal serum Vitamin B12.,"Is the triple ""vitamin B12 predisposes depressive disorder"" supported by the sentence: ""Risk of depression in pregnant women with low-normal serum Vitamin B12.""?",False, -20875915,vitamin B12 predisposes chronic kidney disease,2168,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""vitamin B12 predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, -15081186,vitamin B12 predisposes osteoporosis,2169,BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.,"Is the triple ""vitamin B12 predisposes osteoporosis"" supported by the sentence: ""BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.""?",False, -12678935,vitamin B12 predisposes atherosclerosis,2170,"Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.","Is the triple ""vitamin B12 predisposes atherosclerosis"" supported by the sentence: ""Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.""?",False, -12664527,vitamin B12 predisposes Alzheimer disease,2171,"OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.","Is the triple ""vitamin B12 predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.""?",False, -8590188,vitamin B12 predisposes anemia,2172,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""vitamin B12 predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, -22149451,Ipragliflozin affects type 2 diabetes mellitus,2173,"Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.","Is the triple ""Ipragliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.""?",False, -24120079,Ertugliflozin disrupts diabetes mellitus,2174,"Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.","Is the triple ""Ertugliflozin disrupts diabetes mellitus"" supported by the sentence: ""Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.""?",False, -23006843,Empagliflozin related to diabetes mellitus,2175,"We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.","Is the triple ""Empagliflozin related to diabetes mellitus"" supported by the sentence: ""We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.""?",False, -22183651,Empagliflozin related to type 2 diabetes mellitus,2176,Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.,"Is the triple ""Empagliflozin related to type 2 diabetes mellitus"" supported by the sentence: ""Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.""?",False, -24924157,Empagliflozin causes non-alcoholic fatty liver disease,2177,This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.,"Is the triple ""Empagliflozin causes non-alcoholic fatty liver disease"" supported by the sentence: ""This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.""?",False, -23515975,Empagliflozin causes myocardial infarction,2178,"METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).","Is the triple ""Empagliflozin causes myocardial infarction"" supported by the sentence: ""METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).""?",False, -23240834,Empagliflozin causes acute kidney failure,2179,Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.,"Is the triple ""Empagliflozin causes acute kidney failure"" supported by the sentence: ""Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.""?",False, -25094844,Empagliflozin affects diabetes mellitus,2180,Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.,"Is the triple ""Empagliflozin affects diabetes mellitus"" supported by the sentence: ""Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.""?",False, -24520517,Empagliflozin affects Insulin resistance,2181,Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.,"Is the triple ""Empagliflozin affects Insulin resistance"" supported by the sentence: ""Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.""?",False, -24184835,Empagliflozin affects diabetic kidney disease,2182,"Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.","Is the triple ""Empagliflozin affects diabetic kidney disease"" supported by the sentence: ""Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.""?",False, -24091231,Empagliflozin affects kidney disorder,2183,Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.,"Is the triple ""Empagliflozin affects kidney disorder"" supported by the sentence: ""Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.""?",False, -22935616,Empagliflozin affects non-alcoholic fatty liver disease,2184,"Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.","Is the triple ""Empagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.""?",False, -22175650,Empagliflozin affects acute kidney failure,2185,We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.,"Is the triple ""Empagliflozin affects acute kidney failure"" supported by the sentence: ""We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.""?",False, -22027265,Empagliflozin affects type 2 diabetes mellitus,2186,Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.,"Is the triple ""Empagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.""?",False, -21867589,Empagliflozin affects myocardial infarction,2187,Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.,"Is the triple ""Empagliflozin affects myocardial infarction"" supported by the sentence: ""Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.""?",False, -21618629,Empagliflozin affects pulmonary arterial hypertension,2188,"While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.","Is the triple ""Empagliflozin affects pulmonary arterial hypertension"" supported by the sentence: ""While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.""?",False, -22842915,Empagliflozin disrupts type 2 diabetes mellitus,2189,"AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).","Is the triple ""Empagliflozin disrupts type 2 diabetes mellitus"" supported by the sentence: ""AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).""?",False, -23528682,Empagliflozin prevents myocardial infarction,2190,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Empagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, -23286446,Empagliflozin prevents acute kidney failure,2191,"In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.","Is the triple ""Empagliflozin prevents acute kidney failure"" supported by the sentence: ""In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.""?",False, -24551007,Empagliflozin predisposes acute kidney failure,2192,Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.,"Is the triple ""Empagliflozin predisposes acute kidney failure"" supported by the sentence: ""Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.""?",False, -24497752,Empagliflozin predisposes hypoglycemia,2193,We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.,"Is the triple ""Empagliflozin predisposes hypoglycemia"" supported by the sentence: ""We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.""?",False, -23163444,Empagliflozin predisposes diabetic kidney disease,2194,These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.,"Is the triple ""Empagliflozin predisposes diabetic kidney disease"" supported by the sentence: ""These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.""?",False, -21786786,Dapagliflozin related to Alzheimer disease,2195,"For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.","Is the triple ""Dapagliflozin related to Alzheimer disease"" supported by the sentence: ""For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.""?",False, -23582915,Dapagliflozin causes Weight loss,2196,"RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).","Is the triple ""Dapagliflozin causes Weight loss"" supported by the sentence: ""RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).""?",False, -25156234,Dapagliflozin affects non-alcoholic fatty liver disease,2197,The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.,"Is the triple ""Dapagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.""?",False, -23530734,Dapagliflozin affects Albuminuria,2198,The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.,"Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.""?",False, -23107287,Dapagliflozin affects type 1 diabetes mellitus,2199,"In conclusion, dapagliflozin had a significant effect on type 1 diabetes.","Is the triple ""Dapagliflozin affects type 1 diabetes mellitus"" supported by the sentence: ""In conclusion, dapagliflozin had a significant effect on type 1 diabetes.""?",False, -23072376,Dapagliflozin affects ischemia reperfusion injury,2200,"RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.","Is the triple ""Dapagliflozin affects ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.""?",False, -22916804,Dapagliflozin affects diabetic kidney disease,2201,Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.,"Is the triple ""Dapagliflozin affects diabetic kidney disease"" supported by the sentence: ""Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.""?",False, -22845588,Dapagliflozin affects type 2 diabetes mellitus,2202,This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.,"Is the triple ""Dapagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.""?",False, -22578057,Dapagliflozin affects Albuminuria,2203,"The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).","Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).""?",False, -22163310,Dapagliflozin affects Weight loss,2204,The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.,"Is the triple ""Dapagliflozin affects Weight loss"" supported by the sentence: ""The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.""?",False, -21622453,Dapagliflozin affects atrial fibrillation,2205,Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.,"Is the triple ""Dapagliflozin affects atrial fibrillation"" supported by the sentence: ""Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.""?",False, -25362847,Dapagliflozin disrupts acute kidney failure,2206,"Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).","Is the triple ""Dapagliflozin disrupts acute kidney failure"" supported by the sentence: ""Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).""?",False, -23258105,Dapagliflozin disrupts kidney failure,2207,"In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.","Is the triple ""Dapagliflozin disrupts kidney failure"" supported by the sentence: ""In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.""?",False, -22845589,Dapagliflozin disrupts diabetes mellitus,2208,"Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).","Is the triple ""Dapagliflozin disrupts diabetes mellitus"" supported by the sentence: ""Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).""?",False, -23973238,Dapagliflozin prevents type 2 diabetes mellitus,2209,INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .,"Is the triple ""Dapagliflozin prevents type 2 diabetes mellitus"" supported by the sentence: ""INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .""?",False, -23528684,Dapagliflozin prevents myocardial infarction,2210,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Dapagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, -23138841,Dapagliflozin prevents diabetic kidney disease,2211,"Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.","Is the triple ""Dapagliflozin prevents diabetic kidney disease"" supported by the sentence: ""Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.""?",False, -22845590,Dapagliflozin prevents diabetes mellitus,2212,"CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.","Is the triple ""Dapagliflozin prevents diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.""?",False, -22832530,Dapagliflozin prevents kidney failure,2213,BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.,"Is the triple ""Dapagliflozin prevents kidney failure"" supported by the sentence: ""BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.""?",False, -21513723,Dapagliflozin prevents obesity disorder,2214,"We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.","Is the triple ""Dapagliflozin prevents obesity disorder"" supported by the sentence: ""We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.""?",False, -25236689,Dapagliflozin predisposes kidney failure,2215,"CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.","Is the triple ""Dapagliflozin predisposes kidney failure"" supported by the sentence: ""CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.""?",False, -23072379,Dapagliflozin predisposes myocardial infarction,2216,"Also, the administration of DAPA mitigated the production of myocardial infarction markers.","Is the triple ""Dapagliflozin predisposes myocardial infarction"" supported by the sentence: ""Also, the administration of DAPA mitigated the production of myocardial infarction markers.""?",False, -20833370,Methyldopa related to type 1 diabetes mellitus,2217,"SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.","Is the triple ""Methyldopa related to type 1 diabetes mellitus"" supported by the sentence: ""SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.""?",False, -15433400,Methyldopa related to preeclampsia,2218,"Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.","Is the triple ""Methyldopa related to preeclampsia"" supported by the sentence: ""Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.""?",False, -7364754,Methyldopa related to hypertensive disorder,2219,"[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].","Is the triple ""Methyldopa related to hypertensive disorder"" supported by the sentence: ""[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].""?",False, -25805913,Methyldopa causes hypertensive disorder,2220,Letter: Methyldopa-induced hypertension.,"Is the triple ""Methyldopa causes hypertensive disorder"" supported by the sentence: ""Letter: Methyldopa-induced hypertension.""?",False, -23430063,Methyldopa causes preeclampsia,2221,"The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.","Is the triple ""Methyldopa causes preeclampsia"" supported by the sentence: ""The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.""?",False, -26257846,Methyldopa affects hypertensive disorder,2222,"In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.","Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.""?",False, -10671192,Methyldopa affects hypertensive disorder,2223,A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.,"Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.""?",False, -26170425,Methyldopa prevents hypertensive disorder,2224,Methyldopa decreased the supine hypertension and increased the standing blood pressure.,"Is the triple ""Methyldopa prevents hypertensive disorder"" supported by the sentence: ""Methyldopa decreased the supine hypertension and increased the standing blood pressure.""?",False, -8219214,Methyldopa exacerbates hypertensive disorder,2225,Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.,"Is the triple ""Methyldopa exacerbates hypertensive disorder"" supported by the sentence: ""Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.""?",False, -20611289,Methyldopa predisposes preeclampsia,2226,"There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.","Is the triple ""Methyldopa predisposes preeclampsia"" supported by the sentence: ""There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.""?",False, -19343164,Exemestane related to male breast carcinoma,2227,Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.,"Is the triple ""Exemestane related to male breast carcinoma"" supported by the sentence: ""Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.""?",False, -14849934,Exemestane related to ductal breast carcinoma in situ,2228,CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.,"Is the triple ""Exemestane related to ductal breast carcinoma in situ"" supported by the sentence: ""CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.""?",False, -14694867,Exemestane related to non-small cell lung carcinoma,2229,Further studies are needed to assess the activity of exemestane in NSCLC.,"Is the triple ""Exemestane related to non-small cell lung carcinoma"" supported by the sentence: ""Further studies are needed to assess the activity of exemestane in NSCLC.""?",False, -11511167,Exemestane related to neoplasm,2230,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Exemestane related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, -18732584,Exemestane affects neoplasm,2231,"RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).","Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).""?",False, -14063167,Exemestane affects neoplasm,2232,Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.,"Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.""?",False, -16053578,Exemestane prevents breast neoplasm,2233,"However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.","Is the triple ""Exemestane prevents breast neoplasm"" supported by the sentence: ""However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.""?",False, -20235097,Rivizor disrupts neoplasm,2234,Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.,"Is the triple ""Rivizor disrupts neoplasm"" supported by the sentence: ""Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.""?",False, -24226617,Letrozole related to polycystic ovary syndrome,2235,"Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.","Is the triple ""Letrozole related to polycystic ovary syndrome"" supported by the sentence: ""Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.""?",False, -19925368,Letrozole related to infertility disorder,2236,"OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.","Is the triple ""Letrozole related to infertility disorder"" supported by the sentence: ""OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.""?",False, -13004646,Letrozole related to endometriosis,2237,Letrozole and norethisterone acetate in rectovaginal endometriosis.,"Is the triple ""Letrozole related to endometriosis"" supported by the sentence: ""Letrozole and norethisterone acetate in rectovaginal endometriosis.""?",False, -11511165,Letrozole related to neoplasm,2238,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Letrozole related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, -22485512,Letrozole causes infertility disorder,2239,(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.,"Is the triple ""Letrozole causes infertility disorder"" supported by the sentence: ""(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.""?",False, -17708157,Letrozole causes neoplasm,2240,RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.,"Is the triple ""Letrozole causes neoplasm"" supported by the sentence: ""RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.""?",False, -14659251,Letrozole causes endometriosis,2241,"INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.","Is the triple ""Letrozole causes endometriosis"" supported by the sentence: ""INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.""?",False, -11078418,Letrozole causes polycystic ovary syndrome,2242,Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.,"Is the triple ""Letrozole causes polycystic ovary syndrome"" supported by the sentence: ""Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.""?",False, -10282160,Letrozole causes hypogonadism,2243,"In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.","Is the triple ""Letrozole causes hypogonadism"" supported by the sentence: ""In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.""?",False, -25205942,Letrozole affects ovarian hyperstimulation syndrome,2244,Whether letrozole has a direct effect in reducing OHSS requires further investigation.,"Is the triple ""Letrozole affects ovarian hyperstimulation syndrome"" supported by the sentence: ""Whether letrozole has a direct effect in reducing OHSS requires further investigation.""?",False, -18870552,Letrozole affects Pregnancy,2245,CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.,"Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.""?",False, -18835925,Letrozole affects inflammatory breast carcinoma,2246,"The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.","Is the triple ""Letrozole affects inflammatory breast carcinoma"" supported by the sentence: ""The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.""?",False, -10866444,Letrozole affects Pregnancy,2247,"In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.","Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.""?",False, -7871182,Letrozole affects neoplasm,2248,"The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.","Is the triple ""Letrozole affects neoplasm"" supported by the sentence: ""The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.""?",False, -21352213,Letrozole disrupts Pregnancy,2249,"Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).","Is the triple ""Letrozole disrupts Pregnancy"" supported by the sentence: ""Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).""?",False, -25448977,Letrozole prevents prostate cancer,2250,To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.,"Is the triple ""Letrozole prevents prostate cancer"" supported by the sentence: ""To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.""?",False, -19305611,Letrozole prevents Spontaneous abortion,2251,SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.,"Is the triple ""Letrozole prevents Spontaneous abortion"" supported by the sentence: ""SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.""?",False, -17892609,Letrozole prevents ovarian hyperstimulation syndrome,2252,"Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.","Is the triple ""Letrozole prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.""?",False, -13373696,Letrozole prevents neoplasm,2253,"Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).","Is the triple ""Letrozole prevents neoplasm"" supported by the sentence: ""Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).""?",False, -20363763,Letrozole predisposes ovarian hyperstimulation syndrome,2254,Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.,"Is the triple ""Letrozole predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.""?",False, -19305612,Letrozole predisposes Spontaneous abortion,2255,"MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).","Is the triple ""Letrozole predisposes Spontaneous abortion"" supported by the sentence: ""MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).""?",False, -26765214,Formestane affects neoplasm,2256,"In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.","Is the triple ""Formestane affects neoplasm"" supported by the sentence: ""In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.""?",False, -25526748,Formestane disrupts neoplasm,2257,Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.,"Is the triple ""Formestane disrupts neoplasm"" supported by the sentence: ""Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.""?",False, -13022860,Formestane prevents neoplasm,2258,"Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.","Is the triple ""Formestane prevents neoplasm"" supported by the sentence: ""Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.""?",False, -26325498,Aminoglutethimide affects neoplasm,2259,The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.,"Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.""?",False, -12185634,Aminoglutethimide affects neoplasm,2260,"Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.","Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.""?",False, -22275813,Relugolix related to prostate cancer,2261,Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.,"Is the triple ""Relugolix related to prostate cancer"" supported by the sentence: ""Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.""?",False, -23469407,Relugolix prevents Pain,2262,CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.,"Is the triple ""Relugolix prevents Pain"" supported by the sentence: ""CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.""?",False, -25422975,Abiraterone related to castration-resistant prostate carcinoma,2263,CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.,"Is the triple ""Abiraterone related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.""?",False, -20717678,Abiraterone related to prostate cancer,2264,Abiraterone and spironolactone in prostate cancer: a combination to avoid.,"Is the triple ""Abiraterone related to prostate cancer"" supported by the sentence: ""Abiraterone and spironolactone in prostate cancer: a combination to avoid.""?",False, -16721978,Abiraterone affects prostate cancer,2265,The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.,"Is the triple ""Abiraterone affects prostate cancer"" supported by the sentence: ""The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.""?",False, -15794241,Abiraterone prevents neoplasm,2266,"The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.","Is the triple ""Abiraterone prevents neoplasm"" supported by the sentence: ""The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.""?",False, -19010753,Abiraterone predisposes prostate cancer,2267,"The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.","Is the triple ""Abiraterone predisposes prostate cancer"" supported by the sentence: ""The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.""?",False, -11344546,Finasteride related to acne,2268,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to acne"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, -11344545,Finasteride related to alopecia,2269,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to alopecia"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, -9840638,Finasteride related to prostate cancer,2270,CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.,"Is the triple ""Finasteride related to prostate cancer"" supported by the sentence: ""CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.""?",False, -7359591,Finasteride related to benign prostatic hyperplasia,2271,"CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).","Is the triple ""Finasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).""?",False, -21759063,Finasteride causes benign prostatic hyperplasia,2272,"Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.","Is the triple ""Finasteride causes benign prostatic hyperplasia"" supported by the sentence: ""Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.""?",False, -11694493,Finasteride causes prostate cancer,2273,"The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).","Is the triple ""Finasteride causes prostate cancer"" supported by the sentence: ""The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).""?",False, -11326933,Finasteride affects prostate cancer,2274,The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.,"Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.""?",False, -9873046,Finasteride affects benign prostatic hyperplasia,2275,Indeed the effect of finasteride in BPH was proven in clinical studies.,"Is the triple ""Finasteride affects benign prostatic hyperplasia"" supported by the sentence: ""Indeed the effect of finasteride in BPH was proven in clinical studies.""?",False, -9845785,Finasteride affects alopecia,2276,We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.,"Is the triple ""Finasteride affects alopecia"" supported by the sentence: ""We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.""?",False, -7857572,Finasteride affects prostate cancer,2277,"To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.","Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.""?",False, -21155186,Finasteride disrupts benign prostatic hyperplasia,2278,"Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.","Is the triple ""Finasteride disrupts benign prostatic hyperplasia"" supported by the sentence: ""Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.""?",False, -10949204,Finasteride disrupts prostate cancer,2279,The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.,"Is the triple ""Finasteride disrupts prostate cancer"" supported by the sentence: ""The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.""?",False, -7931250,Finasteride disrupts alopecia,2280,Finasteride can also be used to stop male baldness.,"Is the triple ""Finasteride disrupts alopecia"" supported by the sentence: ""Finasteride can also be used to stop male baldness.""?",False, -11279550,Finasteride prevents benign prostatic hyperplasia,2281,Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.,"Is the triple ""Finasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.""?",False, -8938663,Finasteride prevents alopecia,2282,It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.,"Is the triple ""Finasteride prevents alopecia"" supported by the sentence: ""It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.""?",False, -7857569,Finasteride prevents prostate cancer,2283,Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.,"Is the triple ""Finasteride prevents prostate cancer"" supported by the sentence: ""Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.""?",False, -9840634,Finasteride predisposes prostate cancer,2284,"Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).","Is the triple ""Finasteride predisposes prostate cancer"" supported by the sentence: ""Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).""?",False, -8913536,Finasteride predisposes benign prostatic hyperplasia,2285,"CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.","Is the triple ""Finasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.""?",False, -15677403,Dutasteride related to benign prostatic hyperplasia,2286,"CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.","Is the triple ""Dutasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.""?",False, -14665250,Dutasteride related to prostate cancer,2287,"Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.","Is the triple ""Dutasteride related to prostate cancer"" supported by the sentence: ""Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.""?",False, -22506276,Dutasteride causes prostatitis,2288,Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.,"Is the triple ""Dutasteride causes prostatitis"" supported by the sentence: ""Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.""?",False, -14995448,Dutasteride affects prostate cancer,2289,"Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.","Is the triple ""Dutasteride affects prostate cancer"" supported by the sentence: ""Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.""?",False, -11407079,Dutasteride affects prostatitis,2290,"Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.","Is the triple ""Dutasteride affects prostatitis"" supported by the sentence: ""Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.""?",False, -10333399,Dutasteride affects benign prostatic hyperplasia,2291,"OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.","Is the triple ""Dutasteride affects benign prostatic hyperplasia"" supported by the sentence: ""OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.""?",False, -15838005,Dutasteride disrupts prostate cancer,2292,"BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.","Is the triple ""Dutasteride disrupts prostate cancer"" supported by the sentence: ""BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.""?",False, -16876475,Dutasteride prevents benign prostatic hyperplasia,2293,"On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).","Is the triple ""Dutasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).""?",False, -13018366,Dutasteride prevents alopecia,2294,"CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.","Is the triple ""Dutasteride prevents alopecia"" supported by the sentence: ""CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.""?",False, -12506526,Dutasteride prevents prostate cancer,2295,"Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.","Is the triple ""Dutasteride prevents prostate cancer"" supported by the sentence: ""Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.""?",False, -13749427,Dutasteride predisposes benign prostatic hyperplasia,2296,The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.,"Is the triple ""Dutasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.""?",False, -13628345,Dutasteride predisposes prostate cancer,2297,Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.,"Is the triple ""Dutasteride predisposes prostate cancer"" supported by the sentence: ""Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.""?",False, -23122900,Celecoxib related to Pain,2298,"The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.","Is the triple ""Celecoxib related to Pain"" supported by the sentence: ""The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.""?",False, -20821764,Celecoxib related to prostate cancer,2299,"Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.","Is the triple ""Celecoxib related to prostate cancer"" supported by the sentence: ""Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.""?",False, -14485082,Celecoxib related to castration-resistant prostate carcinoma,2300,"Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.","Is the triple ""Celecoxib related to castration-resistant prostate carcinoma"" supported by the sentence: ""Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.""?",False, -14288130,Celecoxib related to neoplasm,2301,"Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).","Is the triple ""Celecoxib related to neoplasm"" supported by the sentence: ""Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).""?",False, -15210658,Celecoxib related to Cyclooxygenase 2,2302,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, -15210658,Celecoxib related to Cyclooxygenase 2,2303,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, -11056859,Celecoxib coexists with Cyclooxygenase 2,2304,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, -11056859,Celecoxib coexists with Cyclooxygenase 2,2305,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, -19664582,Celecoxib coexists with Cyclooxygenase 2,2306,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, -19664582,Celecoxib coexists with Cyclooxygenase 2,2307,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, -8460221,Celecoxib physically interacts with Cyclooxygenase 2,2308,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, -9140190,Celecoxib physically interacts with Cyclooxygenase 2,2309,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, -22101111,Celecoxib causes Alzheimer disease,2310,"In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).","Is the triple ""Celecoxib causes Alzheimer disease"" supported by the sentence: ""In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).""?",False, -21110777,Celecoxib causes schizophrenia,2311,"We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.","Is the triple ""Celecoxib causes schizophrenia"" supported by the sentence: ""We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.""?",False, -20555672,Celecoxib causes hepatocellular carcinoma,2312,"The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.","Is the triple ""Celecoxib causes hepatocellular carcinoma"" supported by the sentence: ""The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.""?",False, -14478589,Celecoxib causes Inflammation,2313,"In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.","Is the triple ""Celecoxib causes Inflammation"" supported by the sentence: ""In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.""?",False, -14396158,Celecoxib causes neoplasm,2314,"In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.","Is the triple ""Celecoxib causes neoplasm"" supported by the sentence: ""In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.""?",False, -13894212,Celecoxib causes peptic ulcer disease,2315,"AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.","Is the triple ""Celecoxib causes peptic ulcer disease"" supported by the sentence: ""AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.""?",False, -13829410,Celecoxib causes Pain,2316,"Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.","Is the triple ""Celecoxib causes Pain"" supported by the sentence: ""Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.""?",False, -12882318,Celecoxib causes colorectal neoplasm,2317,"We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.","Is the triple ""Celecoxib causes colorectal neoplasm"" supported by the sentence: ""We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.""?",False, -12147702,Celecoxib causes osteoarthritis,2318,"CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.","Is the triple ""Celecoxib causes osteoarthritis"" supported by the sentence: ""CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.""?",False, -12029200,Celecoxib causes Hemorrhage,2319,"Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.","Is the triple ""Celecoxib causes Hemorrhage"" supported by the sentence: ""Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.""?",False, -10018014,Celecoxib causes hypertensive disorder,2320,"A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.","Is the triple ""Celecoxib causes hypertensive disorder"" supported by the sentence: ""A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.""?",False, -25555760,Celecoxib affects postpartum depression,2321,"METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.","Is the triple ""Celecoxib affects postpartum depression"" supported by the sentence: ""METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.""?",False, -21116356,Celecoxib affects major depressive disorder,2322,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Celecoxib affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, -19634803,Celecoxib affects Hemorrhage,2323,Therapy: Celecoxib reduces risk of ulcer bleeding.,"Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""Therapy: Celecoxib reduces risk of ulcer bleeding.""?",False, -18087191,Celecoxib affects breast neoplasm,2324,The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.,"Is the triple ""Celecoxib affects breast neoplasm"" supported by the sentence: ""The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.""?",False, -17669654,Celecoxib affects glioma,2325,Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.,"Is the triple ""Celecoxib affects glioma"" supported by the sentence: ""Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.""?",False, -17634409,Celecoxib affects depressive disorder,2326,Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.,"Is the triple ""Celecoxib affects depressive disorder"" supported by the sentence: ""Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.""?",False, -16787676,Celecoxib affects hypertensive disorder,2327,CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.,"Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.""?",False, -15889622,Celecoxib affects osteoarthritis,2328,"Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.","Is the triple ""Celecoxib affects osteoarthritis"" supported by the sentence: ""Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.""?",False, -13667242,Celecoxib affects obesity disorder,2329,"CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.","Is the triple ""Celecoxib affects obesity disorder"" supported by the sentence: ""CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.""?",False, -13414910,Celecoxib affects Hemorrhage,2330,"We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).","Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).""?",False, -13122831,Celecoxib affects hypertensive disorder,2331,"However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.","Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.""?",False, -12419082,Celecoxib affects neoplasm,2332,"In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.""?",False, -11947530,Celecoxib affects hepatocellular carcinoma,2333,Antitumoral effect of celecoxib in hepatocellular carcinoma.,"Is the triple ""Celecoxib affects hepatocellular carcinoma"" supported by the sentence: ""Antitumoral effect of celecoxib in hepatocellular carcinoma.""?",False, -11444192,Celecoxib affects neoplasm,2334,"Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.""?",False, -11303331,Celecoxib affects non-small cell lung carcinoma,2335,"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.","Is the triple ""Celecoxib affects non-small cell lung carcinoma"" supported by the sentence: ""Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.""?",False, -10337670,Celecoxib affects colorectal neoplasm,2336,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Celecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, -10157341,Celecoxib affects injury,2337,"Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.","Is the triple ""Celecoxib affects injury"" supported by the sentence: ""Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.""?",False, -9967873,Celecoxib affects Palmar-plantar erythrodysesthesia syndrome,2338,Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.,"Is the triple ""Celecoxib affects Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.""?",False, -9574485,Celecoxib affects schizophrenia,2339,"METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.","Is the triple ""Celecoxib affects schizophrenia"" supported by the sentence: ""METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.""?",False, -9038473,Celecoxib affects peptic ulcer disease,2340,"The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.","Is the triple ""Celecoxib affects peptic ulcer disease"" supported by the sentence: ""The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.""?",False, -7841958,Celecoxib affects rheumatoid arthritis,2341,Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.,"Is the triple ""Celecoxib affects rheumatoid arthritis"" supported by the sentence: ""Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.""?",False, -7726669,Celecoxib affects Pain,2342,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Pain"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, -7726668,Celecoxib affects Inflammation,2343,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Inflammation"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, -7264055,Celecoxib affects Cyclooxygenase 2,2344,"Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.""?",False, -11464194,Celecoxib affects Cyclooxygenase 2,2345,"In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.""?",False, -11846592,Celecoxib produces Cyclooxygenase 2,2346,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, -11846592,Celecoxib produces Cyclooxygenase 2,2347,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, -14865798,Celecoxib has input Cyclooxygenase 2,2348,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, -14865798,Celecoxib has input Cyclooxygenase 2,2349,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, -22029254,Celecoxib disrupts major depressive disorder,2350,Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.,"Is the triple ""Celecoxib disrupts major depressive disorder"" supported by the sentence: ""Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.""?",False, -16862201,Celecoxib disrupts hepatocellular carcinoma,2351,"Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.","Is the triple ""Celecoxib disrupts hepatocellular carcinoma"" supported by the sentence: ""Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.""?",False, -15337601,Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome,2352,"RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).","Is the triple ""Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).""?",False, -15029907,Celecoxib disrupts Pain,2353,"RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.","Is the triple ""Celecoxib disrupts Pain"" supported by the sentence: ""RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.""?",False, -14234726,Celecoxib disrupts adenoma,2354,"Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.","Is the triple ""Celecoxib disrupts adenoma"" supported by the sentence: ""Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.""?",False, -12025752,Celecoxib disrupts colonic neoplasm,2355,Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.,"Is the triple ""Celecoxib disrupts colonic neoplasm"" supported by the sentence: ""Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.""?",False, -9589598,Celecoxib disrupts neoplasm,2356,"RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.","Is the triple ""Celecoxib disrupts neoplasm"" supported by the sentence: ""RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.""?",False, -9384934,Celecoxib disrupts breast neoplasm,2357,Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.,"Is the triple ""Celecoxib disrupts breast neoplasm"" supported by the sentence: ""Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.""?",False, -8528907,Celecoxib disrupts Inflammation,2358,"Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).","Is the triple ""Celecoxib disrupts Inflammation"" supported by the sentence: ""Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).""?",False, -19393781,Celecoxib prevents stroke disorder,2359,"Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].","Is the triple ""Celecoxib prevents stroke disorder"" supported by the sentence: ""Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].""?",False, -18309561,Celecoxib prevents hepatocellular carcinoma,2360,"In addition, celecoxib was found to significantly reduce HCC progression.","Is the triple ""Celecoxib prevents hepatocellular carcinoma"" supported by the sentence: ""In addition, celecoxib was found to significantly reduce HCC progression.""?",False, -17468664,Celecoxib prevents non-small cell lung carcinoma,2361,"In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.","Is the triple ""Celecoxib prevents non-small cell lung carcinoma"" supported by the sentence: ""In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.""?",False, -16386169,Celecoxib prevents actinic keratosis,2362,QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?,"Is the triple ""Celecoxib prevents actinic keratosis"" supported by the sentence: ""QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?""?",False, -16323754,Celecoxib prevents hypertensive disorder,2363,"RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.","Is the triple ""Celecoxib prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.""?",False, -15947575,Celecoxib prevents osteoarthritis,2364,"OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.","Is the triple ""Celecoxib prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.""?",False, -15337603,Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome,2365,"CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.","Is the triple ""Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.""?",False, -14688780,Celecoxib prevents Low back pain,2366,RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.,"Is the triple ""Celecoxib prevents Low back pain"" supported by the sentence: ""RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.""?",False, -13346756,Celecoxib prevents prostate cancer,2367,A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.,"Is the triple ""Celecoxib prevents prostate cancer"" supported by the sentence: ""A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.""?",False, -12969778,Celecoxib prevents neuroblastoma,2368,Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.,"Is the triple ""Celecoxib prevents neuroblastoma"" supported by the sentence: ""Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.""?",False, -12687466,Celecoxib prevents adenoma,2369,Risks and benefits of celecoxib to prevent recurrent adenomas.,"Is the triple ""Celecoxib prevents adenoma"" supported by the sentence: ""Risks and benefits of celecoxib to prevent recurrent adenomas.""?",False, -11060421,Celecoxib prevents classic familial adenomatous polyposis,2370,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Celecoxib prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, -10931690,Celecoxib prevents breast neoplasm,2371,"The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.","Is the triple ""Celecoxib prevents breast neoplasm"" supported by the sentence: ""The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.""?",False, -10337661,Celecoxib prevents colorectal neoplasm,2372,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Celecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, -9969498,Celecoxib prevents Acute Pain,2373,"Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.","Is the triple ""Celecoxib prevents Acute Pain"" supported by the sentence: ""Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.""?",False, -9525867,Celecoxib prevents injury,2374,Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.,"Is the triple ""Celecoxib prevents injury"" supported by the sentence: ""Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.""?",False, -9508533,Celecoxib prevents Pain,2375,IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.,"Is the triple ""Celecoxib prevents Pain"" supported by the sentence: ""IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.""?",False, -8844228,Celecoxib prevents Inflammation,2376,"Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.","Is the triple ""Celecoxib prevents Inflammation"" supported by the sentence: ""Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.""?",False, -7720173,Celecoxib prevents neoplasm,2377,The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.,"Is the triple ""Celecoxib prevents neoplasm"" supported by the sentence: ""The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.""?",False, -14426267,Celecoxib predisposes Inflammation,2378,"In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.","Is the triple ""Celecoxib predisposes Inflammation"" supported by the sentence: ""In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.""?",False, -12799788,Celecoxib predisposes hypertensive disorder,2379,"Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.","Is the triple ""Celecoxib predisposes hypertensive disorder"" supported by the sentence: ""Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.""?",False, -11130431,Celecoxib predisposes injury,2380,CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.,"Is the triple ""Celecoxib predisposes injury"" supported by the sentence: ""CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.""?",False, -12352394,Rofecoxib related to Cyclooxygenase 2,2381,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, -12352394,Rofecoxib related to Cyclooxygenase 2,2382,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, -14685035,Rofecoxib related to Cyclooxygenase 2,2383,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, -14685035,Rofecoxib related to Cyclooxygenase 2,2384,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, -8460222,Rofecoxib physically interacts with Cyclooxygenase 2,2385,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, -9140191,Rofecoxib physically interacts with Cyclooxygenase 2,2386,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, -10265772,Rofecoxib causes Pain,2387,We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.,"Is the triple ""Rofecoxib causes Pain"" supported by the sentence: ""We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.""?",False, -13140649,Rofecoxib affects Pain,2388,"Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.","Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.""?",False, -13143485,Rofecoxib affects osteoarthritis,2389,Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).""?",False, -12129893,Rofecoxib affects adenoma,2390,Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.,"Is the triple ""Rofecoxib affects adenoma"" supported by the sentence: ""Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.""?",False, -11539323,Rofecoxib affects Pain,2391,Effect of rofecoxib on pain caused by osteoid osteoma.,"Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Effect of rofecoxib on pain caused by osteoid osteoma.""?",False, -10337671,Rofecoxib affects colorectal neoplasm,2392,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Rofecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, -8436303,Rofecoxib affects osteoarthritis,2393,The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.""?",False, -7546790,Rofecoxib affects Cyclooxygenase 2,2394,"Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.""?",False, -11143316,Rofecoxib affects Cyclooxygenase 2,2395,"Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.""?",False, -11899486,Rofecoxib disrupts Pain,2396,Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.,"Is the triple ""Rofecoxib disrupts Pain"" supported by the sentence: ""Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.""?",False, -12422414,Rofecoxib prevents adenoma,2397,BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.,"Is the triple ""Rofecoxib prevents adenoma"" supported by the sentence: ""BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.""?",False, -10337662,Rofecoxib prevents colorectal neoplasm,2398,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Rofecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, -9488144,Rofecoxib prevents Pain,2399,"This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.","Is the triple ""Rofecoxib prevents Pain"" supported by the sentence: ""This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.""?",False, -12808149,Rofecoxib predisposes adenoma,2400,Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).,"Is the triple ""Rofecoxib predisposes adenoma"" supported by the sentence: ""Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).""?",False, -21440548,Etoricoxib affects osteoarthritis,2401,"In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.","Is the triple ""Etoricoxib affects osteoarthritis"" supported by the sentence: ""In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.""?",False, -17783506,Etoricoxib affects injury,2402,The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.,"Is the triple ""Etoricoxib affects injury"" supported by the sentence: ""The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.""?",False, -15015650,Etoricoxib affects Pain,2403,DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.,"Is the triple ""Etoricoxib affects Pain"" supported by the sentence: ""DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.""?",False, -13276651,Etoricoxib affects rheumatic disorder,2404,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Etoricoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, -8656381,Etoricoxib affects Cyclooxygenase 2,2405,"In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.","Is the triple ""Etoricoxib affects Cyclooxygenase 2"" supported by the sentence: ""In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.""?",False, -21271381,Etoricoxib prevents osteoarthritis,2406,The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.,"Is the triple ""Etoricoxib prevents osteoarthritis"" supported by the sentence: ""The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.""?",False, -17783508,Etoricoxib prevents injury,2407,The results of this study show that etoricoxib treatment could decrease kidney injury during IR.,"Is the triple ""Etoricoxib prevents injury"" supported by the sentence: ""The results of this study show that etoricoxib treatment could decrease kidney injury during IR.""?",False, -13679347,Etoricoxib prevents Pain,2408,CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.,"Is the triple ""Etoricoxib prevents Pain"" supported by the sentence: ""CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.""?",False, -11619190,Lumiracoxib coexists with Cyclooxygenase 2,2409,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, -11619190,Lumiracoxib coexists with Cyclooxygenase 2,2410,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, -17164065,Lumiracoxib physically interacts with Cyclooxygenase 2,2411,The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.,"Is the triple ""Lumiracoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.""?",False, -13276652,Lumiracoxib affects rheumatic disorder,2412,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Lumiracoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, -10245332,Lumiracoxib affects Cyclooxygenase 2,2413,"Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.","Is the triple ""Lumiracoxib affects Cyclooxygenase 2"" supported by the sentence: ""Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.""?",False, -13077914,Valdecoxib physically interacts with Cyclooxygenase 2,2414,We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.,"Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.""?",False, -11476053,Valdecoxib physically interacts with Cyclooxygenase 2,2415,"Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).","Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).""?",False, -9552647,Valdecoxib affects Cyclooxygenase 2,2416,"Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].","Is the triple ""Valdecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].""?",False, -11215677,Valdecoxib disrupts Pain,2417,Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.,"Is the triple ""Valdecoxib disrupts Pain"" supported by the sentence: ""Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.""?",False, -15156435,Valdecoxib prevents pancreatitis,2418,CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.,"Is the triple ""Valdecoxib prevents pancreatitis"" supported by the sentence: ""CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.""?",False, -10035578,Valdecoxib prevents Pain,2419,"Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.","Is the triple ""Valdecoxib prevents Pain"" supported by the sentence: ""Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.""?",False, -17909160,Parecoxib coexists with Cyclooxygenase 2,2420,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, -17909160,Parecoxib coexists with Cyclooxygenase 2,2421,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, -16597136,Parecoxib affects Shoulder pain,2422,BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.,"Is the triple ""Parecoxib affects Shoulder pain"" supported by the sentence: ""BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.""?",False, -13492238,Parecoxib affects Pain,2423,Preventive effects of perioperative parecoxib on post-discectomy pain.,"Is the triple ""Parecoxib affects Pain"" supported by the sentence: ""Preventive effects of perioperative parecoxib on post-discectomy pain.""?",False, -12600950,Parecoxib affects Cyclooxygenase 2,2424,Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.,"Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.""?",False, -18579418,Parecoxib affects Cyclooxygenase 2,2425,"While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).","Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).""?",False, -18207264,Parecoxib disrupts Pain,2426,"Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).","Is the triple ""Parecoxib disrupts Pain"" supported by the sentence: ""Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).""?",False, -16597135,Parecoxib prevents Shoulder pain,2427,"Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.","Is the triple ""Parecoxib prevents Shoulder pain"" supported by the sentence: ""Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.""?",False, -14081775,Parecoxib prevents Pain,2428,RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.,"Is the triple ""Parecoxib prevents Pain"" supported by the sentence: ""RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.""?",False, -22281663,Drospirenone related to polycystic ovary syndrome,2429,"METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.","Is the triple ""Drospirenone related to polycystic ovary syndrome"" supported by the sentence: ""METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.""?",False, -21546756,Drospirenone related to acne,2430,"Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).","Is the triple ""Drospirenone related to acne"" supported by the sentence: ""Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).""?",False, -20964606,Drospirenone predisposes polycystic ovary syndrome,2431,"Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.","Is the triple ""Drospirenone predisposes polycystic ovary syndrome"" supported by the sentence: ""Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.""?",False, -8455182,Ropinirole related to Parkinson disease,2432,Ropinirole as compared with levodopa in Parkinson's disease.,"Is the triple ""Ropinirole related to Parkinson disease"" supported by the sentence: ""Ropinirole as compared with levodopa in Parkinson's disease.""?",False, -17774585,Ropinirole causes Parkinson disease,2433,"Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.","Is the triple ""Ropinirole causes Parkinson disease"" supported by the sentence: ""Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.""?",False, -14587825,Ropinirole affects Parkinson disease,2434,An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.,"Is the triple ""Ropinirole affects Parkinson disease"" supported by the sentence: ""An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.""?",False, -11791368,Ropinirole affects restless legs syndrome,2435,The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.,"Is the triple ""Ropinirole affects restless legs syndrome"" supported by the sentence: ""The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.""?",False, -9334943,Ropinirole disrupts Parkinson disease,2436,"A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).","Is the triple ""Ropinirole disrupts Parkinson disease"" supported by the sentence: ""A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).""?",False, -10286489,Ropinirole prevents Parkinson disease,2437,"Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.","Is the triple ""Ropinirole prevents Parkinson disease"" supported by the sentence: ""Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.""?",False, -27727471,Pergolide related to Parkinson disease,2438,Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.,"Is the triple ""Pergolide related to Parkinson disease"" supported by the sentence: ""Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.""?",False, -11914502,Pergolide causes Parkinson disease,2439,"The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.","Is the triple ""Pergolide causes Parkinson disease"" supported by the sentence: ""The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.""?",False, -10881399,Pergolide affects Parkinson disease,2440,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pergolide affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, -16163315,Bromocriptine related to Parkinson disease,2441,Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.,"Is the triple ""Bromocriptine related to Parkinson disease"" supported by the sentence: ""Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.""?",False, -15233295,Bromocriptine related to type 1 diabetes mellitus,2442,Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.,"Is the triple ""Bromocriptine related to type 1 diabetes mellitus"" supported by the sentence: ""Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.""?",False, -17352665,Bromocriptine causes obesity disorder,2443,"SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.","Is the triple ""Bromocriptine causes obesity disorder"" supported by the sentence: ""SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.""?",False, -12630193,Bromocriptine causes Parkinson disease,2444,"The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.","Is the triple ""Bromocriptine causes Parkinson disease"" supported by the sentence: ""The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.""?",False, -22488533,Bromocriptine affects adenomyosis,2445,The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.,"Is the triple ""Bromocriptine affects adenomyosis"" supported by the sentence: ""The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.""?",False, -20888778,Bromocriptine affects Parkinson disease,2446,"Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.","Is the triple ""Bromocriptine affects Parkinson disease"" supported by the sentence: ""Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.""?",False, -27647530,Bromocriptine prevents obesity disorder,2447,"Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.","Is the triple ""Bromocriptine prevents obesity disorder"" supported by the sentence: ""Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.""?",False, -15529387,Bromocriptine prevents ovarian hyperstimulation syndrome,2448,Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.,"Is the triple ""Bromocriptine prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.""?",False, -18216941,Piribedil causes Parkinson disease,2449,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Piribedil causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, -8408670,Piribedil affects Parkinson disease,2450,Action of piribedil in Parkinson's disease: I.V. test and oral treatment.,"Is the triple ""Piribedil affects Parkinson disease"" supported by the sentence: ""Action of piribedil in Parkinson's disease: I.V. test and oral treatment.""?",False, -8818724,Apomorphine related to Parkinson disease,2451,The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine related to Parkinson disease"" supported by the sentence: ""The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.""?",False, -23018637,Apomorphine causes erectile dysfunction,2452,Apomorphine was used to induce diabetic erectile dysfunction.,"Is the triple ""Apomorphine causes erectile dysfunction"" supported by the sentence: ""Apomorphine was used to induce diabetic erectile dysfunction.""?",False, -11364291,Apomorphine causes Parkinson disease,2453,"Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.","Is the triple ""Apomorphine causes Parkinson disease"" supported by the sentence: ""Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.""?",False, -8320181,Apomorphine affects Parkinson disease,2454,The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine affects Parkinson disease"" supported by the sentence: ""The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.""?",False, -16869339,Cabergoline related to Parkinson disease,2455,OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).,"Is the triple ""Cabergoline related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).""?",False, -19536611,Cabergoline physically interacts with Dopamine D2 Receptor,2456,CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.,"Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.""?",False, -15320456,Cabergoline physically interacts with Dopamine D2 Receptor,2457,"In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.","Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.""?",False, -20751353,Cabergoline causes endometriosis,2458,"Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).","Is the triple ""Cabergoline causes endometriosis"" supported by the sentence: ""Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).""?",False, -26585560,Cabergoline affects pituitary tumor,2459,The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.,"Is the triple ""Cabergoline affects pituitary tumor"" supported by the sentence: ""The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.""?",False, -19237315,Cabergoline affects endometriosis,2460,Effect of Cabergoline in Experimental Endometriosis in Rats.,"Is the triple ""Cabergoline affects endometriosis"" supported by the sentence: ""Effect of Cabergoline in Experimental Endometriosis in Rats.""?",False, -17463083,Cabergoline affects Dopamine D2 Receptor,2461,Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.,"Is the triple ""Cabergoline affects Dopamine D2 Receptor"" supported by the sentence: ""Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.""?",False, -12695381,Cabergoline affects ovarian hyperstimulation syndrome,2462,OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.,"Is the triple ""Cabergoline affects ovarian hyperstimulation syndrome"" supported by the sentence: ""OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.""?",False, -13380476,Cabergoline prevents ovarian hyperstimulation syndrome,2463,Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.,"Is the triple ""Cabergoline prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.""?",False, -9194241,Cabergoline predisposes ovarian hyperstimulation syndrome,2464,"CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.","Is the triple ""Cabergoline predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.""?",False, -15982499,Pramipexole related to restless legs syndrome,2465,"Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.","Is the triple ""Pramipexole related to restless legs syndrome"" supported by the sentence: ""Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.""?",False, -9735890,Pramipexole related to Parkinson disease,2466,Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.,"Is the triple ""Pramipexole related to Parkinson disease"" supported by the sentence: ""Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.""?",False, -21401262,Pramipexole causes restless legs syndrome,2467,Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.,"Is the triple ""Pramipexole causes restless legs syndrome"" supported by the sentence: ""Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.""?",False, -15033700,Pramipexole causes obsessive-compulsive disorder,2468,"CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.","Is the triple ""Pramipexole causes obsessive-compulsive disorder"" supported by the sentence: ""CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.""?",False, -13328857,Pramipexole causes Parkinson disease,2469,"We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.","Is the triple ""Pramipexole causes Parkinson disease"" supported by the sentence: ""We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.""?",False, -18143671,Pramipexole affects depressive disorder,2470,The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.,"Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.""?",False, -12990655,Pramipexole affects restless legs syndrome,2471,The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.,"Is the triple ""Pramipexole affects restless legs syndrome"" supported by the sentence: ""The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.""?",False, -12579916,Pramipexole affects depressive disorder,2472,"Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.","Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.""?",False, -10881401,Pramipexole affects Parkinson disease,2473,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pramipexole affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, -11457313,Pramipexole prevents Parkinson disease,2474,"Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.","Is the triple ""Pramipexole prevents Parkinson disease"" supported by the sentence: ""Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.""?",False, -24610805,Rotigotine affects Parkinson disease,2475,"A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.","Is the triple ""Rotigotine affects Parkinson disease"" supported by the sentence: ""A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.""?",False, -10840977,Norethindrone subclass of Norethindrone acetate,2476,"Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.","Is the triple ""Norethindrone subclass of Norethindrone acetate"" supported by the sentence: ""Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.""?",False, -8232443,Norethindrone related to Norethindrone acetate,2477,"The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.","Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.""?",False, -11686400,Norethindrone related to Norethindrone acetate,2478,OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).,"Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).""?",False, -9474851,Norethindrone coexists with Norethindrone acetate,2479,"The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.","Is the triple ""Norethindrone coexists with Norethindrone acetate"" supported by the sentence: ""The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.""?",False, -9781055,Norethindrone physically interacts with Norethindrone acetate,2480,"Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.","Is the triple ""Norethindrone physically interacts with Norethindrone acetate"" supported by the sentence: ""Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.""?",False, -21462883,Norethindrone causes neoplasm,2481,"Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.","Is the triple ""Norethindrone causes neoplasm"" supported by the sentence: ""Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.""?",False, -27429354,Pramocaine affects Pruritus,2482,Effect of topical pramoxine on experimentally induced pruritus in humans.,"Is the triple ""Pramocaine affects Pruritus"" supported by the sentence: ""Effect of topical pramoxine on experimentally induced pruritus in humans.""?",False, -19275366,Miconazole disrupts fungal infectious disease,2483,"Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.","Is the triple ""Miconazole disrupts fungal infectious disease"" supported by the sentence: ""Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.""?",False, -26511975,Miconazole prevents fungal infectious disease,2484,"The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.","Is the triple ""Miconazole prevents fungal infectious disease"" supported by the sentence: ""The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.""?",False, -26530559,Benzocaine affects Pain,2485,OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.,"Is the triple ""Benzocaine affects Pain"" supported by the sentence: ""OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.""?",False, -8870493,Benzocaine disrupts Pain,2486,CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.,"Is the triple ""Benzocaine disrupts Pain"" supported by the sentence: ""CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.""?",False, -8870496,Benzocaine prevents Pain,2487,"Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.","Is the triple ""Benzocaine prevents Pain"" supported by the sentence: ""Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.""?",False, -25561815,Folic Acid related to systemic lupus erythematosus,2488,Folic acid in systemic lupus erythematosus - a new aspect.,"Is the triple ""Folic Acid related to systemic lupus erythematosus"" supported by the sentence: ""Folic acid in systemic lupus erythematosus - a new aspect.""?",False, -23703706,Folic Acid related to neoplasm of esophagus,2489,"We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.","Is the triple ""Folic Acid related to neoplasm of esophagus"" supported by the sentence: ""We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.""?",False, -23248765,Folic Acid related to chronic renal failure syndrome,2490,"Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.","Is the triple ""Folic Acid related to chronic renal failure syndrome"" supported by the sentence: ""Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.""?",False, -20038856,Folic Acid related to psychotic disorder,2491,Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.,"Is the triple ""Folic Acid related to psychotic disorder"" supported by the sentence: ""Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.""?",False, -19346997,Folic Acid related to myocardial ischemia,2492,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""Folic Acid related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, -19301020,Folic Acid related to type 2 diabetes mellitus,2493,"In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.","Is the triple ""Folic Acid related to type 2 diabetes mellitus"" supported by the sentence: ""In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.""?",False, -19114314,Folic Acid related to tuberculosis,2494,Information about folate status in tuberculosis in developing countries is scanty.,"Is the triple ""Folic Acid related to tuberculosis"" supported by the sentence: ""Information about folate status in tuberculosis in developing countries is scanty.""?",False, -18323097,Folic Acid related to HIV infectious disease,2495,"CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.","Is the triple ""Folic Acid related to HIV infectious disease"" supported by the sentence: ""CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.""?",False, -17591518,Folic Acid related to infertility disorder,2496,Folate is one of the B vitamins which has been suggested to be related to infertility.,"Is the triple ""Folic Acid related to infertility disorder"" supported by the sentence: ""Folate is one of the B vitamins which has been suggested to be related to infertility.""?",False, -15826430,Folic Acid related to male infertility,2497,Folate and vitamin B12 in idiopathic male infertility.,"Is the triple ""Folic Acid related to male infertility"" supported by the sentence: ""Folate and vitamin B12 in idiopathic male infertility.""?",False, -14280104,Folic Acid related to myocardial infarction,2498,"CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.","Is the triple ""Folic Acid related to myocardial infarction"" supported by the sentence: ""CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.""?",False, -12974622,Folic Acid related to osteoporosis,2499,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""Folic Acid related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, -12112288,Folic Acid related to autism spectrum disorder,2500,"Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.","Is the triple ""Folic Acid related to autism spectrum disorder"" supported by the sentence: ""Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.""?",False, -11305980,Folic Acid related to cleft palate,2501,"The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.","Is the triple ""Folic Acid related to cleft palate"" supported by the sentence: ""The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.""?",False, -10745702,Folic Acid related to malaria,2502,Administration of pyrimethamine with folic acid and folinic acids in human malaria.,"Is the triple ""Folic Acid related to malaria"" supported by the sentence: ""Administration of pyrimethamine with folic acid and folinic acids in human malaria.""?",False, -10717915,Folic Acid related to habitual spontaneous abortion,2503,SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.,"Is the triple ""Folic Acid related to habitual spontaneous abortion"" supported by the sentence: ""SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.""?",False, -10644755,Folic Acid related to atherosclerosis,2504,[Use of vitamin B12 and folic acid in atherosclerosis].,"Is the triple ""Folic Acid related to atherosclerosis"" supported by the sentence: ""[Use of vitamin B12 and folic acid in atherosclerosis].""?",False, -10226420,Folic Acid related to cervical polyp,2505,"Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.","Is the triple ""Folic Acid related to cervical polyp"" supported by the sentence: ""Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.""?",False, -10177078,Folic Acid related to colorectal neoplasm,2506,CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.,"Is the triple ""Folic Acid related to colorectal neoplasm"" supported by the sentence: ""CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.""?",False, -10046990,Folic Acid related to depressive disorder,2507,This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.,"Is the triple ""Folic Acid related to depressive disorder"" supported by the sentence: ""This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.""?",False, -9815747,Folic Acid related to hypertensive disorder,2508,"In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.","Is the triple ""Folic Acid related to hypertensive disorder"" supported by the sentence: ""In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.""?",False, -9628243,Folic Acid related to mesothelioma,2509,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to mesothelioma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, -9628242,Folic Acid related to non-small cell lung carcinoma,2510,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to non-small cell lung carcinoma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, -9060030,Folic Acid related to neoplasm,2511,Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.,"Is the triple ""Folic Acid related to neoplasm"" supported by the sentence: ""Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.""?",False, -8875457,Folic Acid related to lymphoma,2512,"The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.","Is the triple ""Folic Acid related to lymphoma"" supported by the sentence: ""The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.""?",False, -8584638,Folic Acid related to sickle cell anemia,2513,Erythrocyte folate does not accurately reflect folate status in sickle cell disease.,"Is the triple ""Folic Acid related to sickle cell anemia"" supported by the sentence: ""Erythrocyte folate does not accurately reflect folate status in sickle cell disease.""?",False, -8274471,Folic Acid related to chronic kidney disease,2514,"In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.","Is the triple ""Folic Acid related to chronic kidney disease"" supported by the sentence: ""In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.""?",False, -8259960,Folic Acid related to type 1 diabetes mellitus,2515,"OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.","Is the triple ""Folic Acid related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.""?",False, -8078141,Folic Acid related to Alzheimer disease,2516,Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.,"Is the triple ""Folic Acid related to Alzheimer disease"" supported by the sentence: ""Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.""?",False, -7868306,Folic Acid related to coronary artery disorder,2517,"In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.","Is the triple ""Folic Acid related to coronary artery disorder"" supported by the sentence: ""In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.""?",False, -7765942,Folic Acid related to anemia,2518,"No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.","Is the triple ""Folic Acid related to anemia"" supported by the sentence: ""No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.""?",False, -7303518,Folic Acid related to epilepsy,2519,"Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.","Is the triple ""Folic Acid related to epilepsy"" supported by the sentence: ""Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.""?",False, -7234301,Folic Acid related to Reduced blood folate concentration,2520,Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.,"Is the triple ""Folic Acid related to Reduced blood folate concentration"" supported by the sentence: ""Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.""?",False, -7229825,Folic Acid related to iron deficiency anemia,2521,Status of labile folate in iron deficiency anaemia.,"Is the triple ""Folic Acid related to iron deficiency anemia"" supported by the sentence: ""Status of labile folate in iron deficiency anaemia.""?",False, -7175279,Folic Acid related to rheumatoid arthritis,2522,[Methotrexate and folates in rheumatoid arthritis].,"Is the triple ""Folic Acid related to rheumatoid arthritis"" supported by the sentence: ""[Methotrexate and folates in rheumatoid arthritis].""?",False, -25522909,Folic Acid causes diabetic kidney disease,2523,"The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.","Is the triple ""Folic Acid causes diabetic kidney disease"" supported by the sentence: ""The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.""?",False, -18689556,Folic Acid causes Alzheimer disease,2524,Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.,"Is the triple ""Folic Acid causes Alzheimer disease"" supported by the sentence: ""Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.""?",False, -17559847,Folic Acid causes iron deficiency anemia,2525,"With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).","Is the triple ""Folic Acid causes iron deficiency anemia"" supported by the sentence: ""With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).""?",False, -17044072,Folic Acid causes depressive disorder,2526,The low blood level of folates is the primary cause of depression in Alzheimer's disease.,"Is the triple ""Folic Acid causes depressive disorder"" supported by the sentence: ""The low blood level of folates is the primary cause of depression in Alzheimer's disease.""?",False, -15826434,Folic Acid causes male infertility,2527,This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.,"Is the triple ""Folic Acid causes male infertility"" supported by the sentence: ""This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.""?",False, -15057448,Folic Acid causes chronic kidney disease,2528,"The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.","Is the triple ""Folic Acid causes chronic kidney disease"" supported by the sentence: ""The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.""?",False, -14954987,Folic Acid causes autism spectrum disorder,2529,"Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.","Is the triple ""Folic Acid causes autism spectrum disorder"" supported by the sentence: ""Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.""?",False, -13825749,Folic Acid causes cleft lip,2530,The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).,"Is the triple ""Folic Acid causes cleft lip"" supported by the sentence: ""The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).""?",False, -13656973,Folic Acid causes neoplasm,2531,Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.,"Is the triple ""Folic Acid causes neoplasm"" supported by the sentence: ""Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.""?",False, -12212539,Folic Acid causes lymphoma,2532,"Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.","Is the triple ""Folic Acid causes lymphoma"" supported by the sentence: ""Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.""?",False, -11472417,Folic Acid causes gingival overgrowth,2533,Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.,"Is the triple ""Folic Acid causes gingival overgrowth"" supported by the sentence: ""Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.""?",False, -11073752,Folic Acid causes myocardial ischemia,2534,[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].,"Is the triple ""Folic Acid causes myocardial ischemia"" supported by the sentence: ""[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].""?",False, -10016854,Folic Acid causes hypertensive disorder,2535,"In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.","Is the triple ""Folic Acid causes hypertensive disorder"" supported by the sentence: ""In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.""?",False, -8671948,Folic Acid causes cleft palate,2536,"These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.","Is the triple ""Folic Acid causes cleft palate"" supported by the sentence: ""These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.""?",False, -8640403,Folic Acid causes epilepsy,2537,Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.,"Is the triple ""Folic Acid causes epilepsy"" supported by the sentence: ""Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.""?",False, -7900734,Folic Acid causes coronary artery disorder,2538,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes coronary artery disorder"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, -7900729,Folic Acid causes atherosclerosis,2539,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, -7637475,Folic Acid causes Reduced blood folate concentration,2540,"The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.","Is the triple ""Folic Acid causes Reduced blood folate concentration"" supported by the sentence: ""The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.""?",False, -7460069,Folic Acid causes anemia,2541,"If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.","Is the triple ""Folic Acid causes anemia"" supported by the sentence: ""If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.""?",False, -7392389,Folic Acid causes neural tube defect,2542,The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.,"Is the triple ""Folic Acid causes neural tube defect"" supported by the sentence: ""The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.""?",False, -27400709,Folic Acid affects coronary artery disorder,2543,"Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.","Is the triple ""Folic Acid affects coronary artery disorder"" supported by the sentence: ""Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.""?",False, -27350602,Folic Acid affects cleft palate,2544,"Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.""?",False, -26684582,Folic Acid affects colorectal neoplasm,2545,The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.,"Is the triple ""Folic Acid affects colorectal neoplasm"" supported by the sentence: ""The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.""?",False, -26504524,Folic Acid affects neoplasm,2546,"In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.""?",False, -26433324,Folic Acid affects psychotic disorder,2547,Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.,"Is the triple ""Folic Acid affects psychotic disorder"" supported by the sentence: ""Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.""?",False, -25046427,Folic Acid affects malaria,2548,Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.,"Is the triple ""Folic Acid affects malaria"" supported by the sentence: ""Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.""?",False, -24121807,Folic Acid affects osteoporosis,2549,"However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.","Is the triple ""Folic Acid affects osteoporosis"" supported by the sentence: ""However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.""?",False, -23769753,Folic Acid affects anemia,2550,Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.,"Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.""?",False, -22602503,Folic Acid affects gingival overgrowth,2551,The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.,"Is the triple ""Folic Acid affects gingival overgrowth"" supported by the sentence: ""The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.""?",False, -21177262,Folic Acid affects autism spectrum disorder,2552,The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.,"Is the triple ""Folic Acid affects autism spectrum disorder"" supported by the sentence: ""The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.""?",False, -20060781,Folic Acid affects Hemorrhage,2553,"Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.","Is the triple ""Folic Acid affects Hemorrhage"" supported by the sentence: ""Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.""?",False, -19336710,Folic Acid affects polycystic ovary syndrome,2554,"Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).","Is the triple ""Folic Acid affects polycystic ovary syndrome"" supported by the sentence: ""Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).""?",False, -19172236,Folic Acid affects chronic kidney disease,2555,"Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.","Is the triple ""Folic Acid affects chronic kidney disease"" supported by the sentence: ""Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.""?",False, -19066599,Folic Acid affects Alzheimer disease,2556,"Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.""?",False, -15798837,Folic Acid affects hypertensive disorder,2557,"BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.","Is the triple ""Folic Acid affects hypertensive disorder"" supported by the sentence: ""BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.""?",False, -15143772,Folic Acid affects Reduced blood folate concentration,2558,"However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.""?",False, -14869410,Folic Acid affects epilepsy,2559,It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.,"Is the triple ""Folic Acid affects epilepsy"" supported by the sentence: ""It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.""?",False, -14664528,Folic Acid affects depressive disorder,2560,Our findings that poor folate status may increase depression needs to be further investigated.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Our findings that poor folate status may increase depression needs to be further investigated.""?",False, -14002988,Folic Acid affects depressive disorder,2561,We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.""?",False, -13092563,Folic Acid affects depressive disorder,2562,"Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.","Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.""?",False, -12773835,Folic Acid affects atherosclerosis,2563,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""Folic Acid affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, -11897009,Folic Acid affects Alzheimer disease,2564,"As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.""?",False, -10798682,Folic Acid affects type 2 diabetes mellitus,2565,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""Folic Acid affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, -10733114,Folic Acid affects Reduced blood folate concentration,2566,"Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.""?",False, -10375553,Folic Acid affects neoplasm,2567,"When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.""?",False, -10355008,Folic Acid affects anemia,2568,"The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.","Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.""?",False, -8962241,Folic Acid affects cleft palate,2569,"OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.""?",False, -8101952,Folic Acid affects neural tube defect,2570,"CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.""?",False, -7127212,Folic Acid affects neural tube defect,2571,"To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.""?",False, -19290979,Folic Acid produces neoplasm,2572,"Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.","Is the triple ""Folic Acid produces neoplasm"" supported by the sentence: ""Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.""?",False, -26301481,Folic Acid disrupts epilepsy,2573,A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.,"Is the triple ""Folic Acid disrupts epilepsy"" supported by the sentence: ""A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.""?",False, -22602502,Folic Acid disrupts gingival overgrowth,2574,"Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.","Is the triple ""Folic Acid disrupts gingival overgrowth"" supported by the sentence: ""Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.""?",False, -21452213,Folic Acid disrupts cleft palate,2575,"Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).","Is the triple ""Folic Acid disrupts cleft palate"" supported by the sentence: ""Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).""?",False, -20711939,Folic Acid disrupts autism spectrum disorder,2576,Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.,"Is the triple ""Folic Acid disrupts autism spectrum disorder"" supported by the sentence: ""Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.""?",False, -20091947,Folic Acid disrupts atherosclerosis,2577,"Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.","Is the triple ""Folic Acid disrupts atherosclerosis"" supported by the sentence: ""Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.""?",False, -18758283,Folic Acid disrupts malaria,2578,"Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.","Is the triple ""Folic Acid disrupts malaria"" supported by the sentence: ""Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.""?",False, -18711179,Folic Acid disrupts hypertensive disorder,2579,"Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.","Is the triple ""Folic Acid disrupts hypertensive disorder"" supported by the sentence: ""Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.""?",False, -16597425,Folic Acid disrupts neoplasm,2580,"Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.","Is the triple ""Folic Acid disrupts neoplasm"" supported by the sentence: ""Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.""?",False, -13887579,Folic Acid disrupts anemia,2581,Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.,"Is the triple ""Folic Acid disrupts anemia"" supported by the sentence: ""Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.""?",False, -13415357,Folic Acid disrupts cleft lip,2582,[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].,"Is the triple ""Folic Acid disrupts cleft lip"" supported by the sentence: ""[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].""?",False, -12569851,Folic Acid disrupts HIV infectious disease,2583,"Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.","Is the triple ""Folic Acid disrupts HIV infectious disease"" supported by the sentence: ""Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.""?",False, -11807458,Folic Acid disrupts colorectal neoplasm,2584,Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.,"Is the triple ""Folic Acid disrupts colorectal neoplasm"" supported by the sentence: ""Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.""?",False, -10170875,Folic Acid disrupts depressive disorder,2585,The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.,"Is the triple ""Folic Acid disrupts depressive disorder"" supported by the sentence: ""The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.""?",False, -8333532,Folic Acid disrupts neural tube defect,2586,"Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.","Is the triple ""Folic Acid disrupts neural tube defect"" supported by the sentence: ""Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.""?",False, -8088152,Folic Acid disrupts Reduced blood folate concentration,2587,"We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.","Is the triple ""Folic Acid disrupts Reduced blood folate concentration"" supported by the sentence: ""We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.""?",False, -7255352,Folic Acid disrupts coronary artery disorder,2588,Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.,"Is the triple ""Folic Acid disrupts coronary artery disorder"" supported by the sentence: ""Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.""?",False, -24827653,Folic Acid prevents Hemorrhage,2589,"Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.","Is the triple ""Folic Acid prevents Hemorrhage"" supported by the sentence: ""Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.""?",False, -19249670,Folic Acid prevents epilepsy,2590,"The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.","Is the triple ""Folic Acid prevents epilepsy"" supported by the sentence: ""The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.""?",False, -18676969,Folic Acid prevents neoplasm,2591,"Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.","Is the triple ""Folic Acid prevents neoplasm"" supported by the sentence: ""Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.""?",False, -17577921,Folic Acid prevents diabetic kidney disease,2592,Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.,"Is the triple ""Folic Acid prevents diabetic kidney disease"" supported by the sentence: ""Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.""?",False, -16233198,Folic Acid prevents iron deficiency anemia,2593,"UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.","Is the triple ""Folic Acid prevents iron deficiency anemia"" supported by the sentence: ""UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.""?",False, -15458838,Folic Acid prevents myocardial ischemia,2594,"Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.","Is the triple ""Folic Acid prevents myocardial ischemia"" supported by the sentence: ""Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.""?",False, -15385859,Folic Acid prevents depressive disorder,2595,These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.,"Is the triple ""Folic Acid prevents depressive disorder"" supported by the sentence: ""These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.""?",False, -13602735,Folic Acid prevents gingival overgrowth,2596,A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.,"Is the triple ""Folic Acid prevents gingival overgrowth"" supported by the sentence: ""A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.""?",False, -12999215,Folic Acid prevents hypertensive disorder,2597,"Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.","Is the triple ""Folic Acid prevents hypertensive disorder"" supported by the sentence: ""Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.""?",False, -12947495,Folic Acid prevents cleft lip,2598,CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.,"Is the triple ""Folic Acid prevents cleft lip"" supported by the sentence: ""CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.""?",False, -12911127,Folic Acid prevents Alzheimer disease,2599,BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.,"Is the triple ""Folic Acid prevents Alzheimer disease"" supported by the sentence: ""BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.""?",False, -11842763,Folic Acid prevents cervical polyp,2600,"Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.","Is the triple ""Folic Acid prevents cervical polyp"" supported by the sentence: ""Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.""?",False, -10283354,Folic Acid prevents heart disorder,2601,"Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?","Is the triple ""Folic Acid prevents heart disorder"" supported by the sentence: ""Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?""?",False, -10242010,Folic Acid prevents cleft palate,2602,"CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.","Is the triple ""Folic Acid prevents cleft palate"" supported by the sentence: ""CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.""?",False, -9547944,Folic Acid prevents atherosclerosis,2603,CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.,"Is the triple ""Folic Acid prevents atherosclerosis"" supported by the sentence: ""CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.""?",False, -9000016,Folic Acid prevents anemia,2604,OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.,"Is the triple ""Folic Acid prevents anemia"" supported by the sentence: ""OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.""?",False, -8746975,Folic Acid prevents Reduced blood folate concentration,2605,The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.,"Is the triple ""Folic Acid prevents Reduced blood folate concentration"" supported by the sentence: ""The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.""?",False, -8675157,Folic Acid prevents coronary artery disorder,2606,"Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.","Is the triple ""Folic Acid prevents coronary artery disorder"" supported by the sentence: ""Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.""?",False, -8467407,Folic Acid prevents myocardial infarction,2607,"Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.","Is the triple ""Folic Acid prevents myocardial infarction"" supported by the sentence: ""Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.""?",False, -7303516,Folic Acid prevents neural tube defect,2608,She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.,"Is the triple ""Folic Acid prevents neural tube defect"" supported by the sentence: ""She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.""?",False, -23795062,Folic Acid predisposes depressive disorder,2609,A low level of folate is also thought to be a risk for depression in adults.,"Is the triple ""Folic Acid predisposes depressive disorder"" supported by the sentence: ""A low level of folate is also thought to be a risk for depression in adults.""?",False, -20875914,Folic Acid predisposes chronic kidney disease,2610,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""Folic Acid predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, -20436878,Folic Acid predisposes psychotic disorder,2611,"Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.","Is the triple ""Folic Acid predisposes psychotic disorder"" supported by the sentence: ""Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.""?",False, -19071958,Folic Acid predisposes type 1 diabetes mellitus,2612,"The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.","Is the triple ""Folic Acid predisposes type 1 diabetes mellitus"" supported by the sentence: ""The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.""?",False, -18723777,Folic Acid predisposes systemic lupus erythematosus,2613,"CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.","Is the triple ""Folic Acid predisposes systemic lupus erythematosus"" supported by the sentence: ""CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.""?",False, -16571781,Folic Acid predisposes habitual spontaneous abortion,2614,"Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.","Is the triple ""Folic Acid predisposes habitual spontaneous abortion"" supported by the sentence: ""Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.""?",False, -16186991,Folic Acid predisposes Reduced blood folate concentration,2615,"This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.","Is the triple ""Folic Acid predisposes Reduced blood folate concentration"" supported by the sentence: ""This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.""?",False, -15780148,Folic Acid predisposes epilepsy,2616,Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.,"Is the triple ""Folic Acid predisposes epilepsy"" supported by the sentence: ""Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.""?",False, -15351663,Folic Acid predisposes breast neoplasm,2617,Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.,"Is the triple ""Folic Acid predisposes breast neoplasm"" supported by the sentence: ""Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.""?",False, -14681570,Folic Acid predisposes malaria,2618,"Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.","Is the triple ""Folic Acid predisposes malaria"" supported by the sentence: ""Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.""?",False, -13204073,Folic Acid predisposes autism spectrum disorder,2619,"Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.","Is the triple ""Folic Acid predisposes autism spectrum disorder"" supported by the sentence: ""Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.""?",False, -12966788,Folic Acid predisposes cleft palate,2620,"In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.","Is the triple ""Folic Acid predisposes cleft palate"" supported by the sentence: ""In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.""?",False, -12851634,Folic Acid predisposes osteoporosis,2621,"We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.","Is the triple ""Folic Acid predisposes osteoporosis"" supported by the sentence: ""We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.""?",False, -12628867,Folic Acid predisposes neoplasm,2622,"In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.","Is the triple ""Folic Acid predisposes neoplasm"" supported by the sentence: ""In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.""?",False, -11373442,Folic Acid predisposes colorectal neoplasm,2623,Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.,"Is the triple ""Folic Acid predisposes colorectal neoplasm"" supported by the sentence: ""Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.""?",False, -11241979,Folic Acid predisposes hypertensive disorder,2624,"CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.","Is the triple ""Folic Acid predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.""?",False, -9419598,Folic Acid predisposes Alzheimer disease,2625,"Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.","Is the triple ""Folic Acid predisposes Alzheimer disease"" supported by the sentence: ""Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.""?",False, -9024956,Folic Acid predisposes non-small cell lung carcinoma,2626,CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.,"Is the triple ""Folic Acid predisposes non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.""?",False, -8876702,Folic Acid predisposes atherosclerosis,2627,"The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.","Is the triple ""Folic Acid predisposes atherosclerosis"" supported by the sentence: ""The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.""?",False, -8590186,Folic Acid predisposes anemia,2628,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""Folic Acid predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, -8210149,Folic Acid predisposes myocardial ischemia,2629,Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.,"Is the triple ""Folic Acid predisposes myocardial ischemia"" supported by the sentence: ""Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.""?",False, -8202566,Folic Acid predisposes coronary artery disorder,2630,"Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.","Is the triple ""Folic Acid predisposes coronary artery disorder"" supported by the sentence: ""Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.""?",False, -7807562,Folic Acid predisposes myocardial infarction,2631,The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.,"Is the triple ""Folic Acid predisposes myocardial infarction"" supported by the sentence: ""The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.""?",False, -7720012,Phenylbutazone subclass of Oxyphenbutazone,2632,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Phenylbutazone subclass of Oxyphenbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, -26246718,Phenylbutazone related to Oxyphenbutazone,2633,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, -25613560,Phenylbutazone related to Oxyphenbutazone,2634,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, -20340997,Phenylbutazone physically interacts with Oxyphenbutazone,2635,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Phenylbutazone physically interacts with Oxyphenbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, -26417219,"Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",2636,"At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.","Is the triple ""Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine"" supported by the sentence: ""At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.""?",False, -17467114,Phenylbutazone affects rheumatic disorder,2637,[Research on the mechanism of action of phenylbutazone in rheumatic diseases].,"Is the triple ""Phenylbutazone affects rheumatic disorder"" supported by the sentence: ""[Research on the mechanism of action of phenylbutazone in rheumatic diseases].""?",False, -8146434,Phenylbutazone affects Oxyphenbutazone,2638,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Phenylbutazone affects Oxyphenbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, -7720012,Oxyphenbutazone subclass of Phenylbutazone,2639,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Oxyphenbutazone subclass of Phenylbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, -25613560,Oxyphenbutazone related to Phenylbutazone,2640,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, -26246718,Oxyphenbutazone related to Phenylbutazone,2641,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, -20340997,Oxyphenbutazone physically interacts with Phenylbutazone,2642,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Oxyphenbutazone physically interacts with Phenylbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, -8146434,Oxyphenbutazone affects Phenylbutazone,2643,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Oxyphenbutazone affects Phenylbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, -19336632,Etofenamate prevents Arthralgia,2644,The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.,"Is the triple ""Etofenamate prevents Arthralgia"" supported by the sentence: ""The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.""?",False, -11418550,Piroxicam subclass of 5'-Hydroxypiroxicam,2645,"The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.","Is the triple ""Piroxicam subclass of 5'-Hydroxypiroxicam"" supported by the sentence: ""The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.""?",False, -27695181,Piroxicam affects osteoarthritis,2646,Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.,"Is the triple ""Piroxicam affects osteoarthritis"" supported by the sentence: ""Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.""?",False, -24435495,Piroxicam affects Pain,2647,The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.,"Is the triple ""Piroxicam affects Pain"" supported by the sentence: ""The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.""?",False, -18791248,Piroxicam disrupts Pain,2648,Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.,"Is the triple ""Piroxicam disrupts Pain"" supported by the sentence: ""Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.""?",False, -13746683,Piroxicam prevents Myalgia,2649,"We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.","Is the triple ""Piroxicam prevents Myalgia"" supported by the sentence: ""We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.""?",False, -13092622,Piroxicam prevents Pain,2650,"CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.","Is the triple ""Piroxicam prevents Pain"" supported by the sentence: ""CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.""?",False, -9050885,Bufexamac related to rheumatic disorder,2651,[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].,"Is the triple ""Bufexamac related to rheumatic disorder"" supported by the sentence: ""[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].""?",False, -27600921,Mometasone furoate related to psoriasis,2652,[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].,"Is the triple ""Mometasone furoate related to psoriasis"" supported by the sentence: ""[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].""?",False, -26936147,Mometasone furoate related to skin disorder,2653,Mometasone versus betamethasone creams: a trial in dermatoses.,"Is the triple ""Mometasone furoate related to skin disorder"" supported by the sentence: ""Mometasone versus betamethasone creams: a trial in dermatoses.""?",False, -20328277,Mometasone furoate related to obstructive sleep apnea syndrome,2654,"Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.","Is the triple ""Mometasone furoate related to obstructive sleep apnea syndrome"" supported by the sentence: ""Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.""?",False, -20031657,Mometasone furoate related to diffuse alopecia areata,2655,Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.,"Is the triple ""Mometasone furoate related to diffuse alopecia areata"" supported by the sentence: ""Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.""?",False, -18451558,Mometasone furoate related to spinal cord injury,2656,The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).,"Is the triple ""Mometasone furoate related to spinal cord injury"" supported by the sentence: ""The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).""?",False, -15193244,Mometasone furoate related to severe acute respiratory syndrome,2657,CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.,"Is the triple ""Mometasone furoate related to severe acute respiratory syndrome"" supported by the sentence: ""CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.""?",False, -12129006,Mometasone furoate related to asthma,2658,Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.,"Is the triple ""Mometasone furoate related to asthma"" supported by the sentence: ""Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.""?",False, -12122099,Mometasone furoate related to allergic rhinitis,2659,"The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.","Is the triple ""Mometasone furoate related to allergic rhinitis"" supported by the sentence: ""The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.""?",False, -11696210,Mometasone furoate related to chronic obstructive pulmonary disease,2660,Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.,"Is the triple ""Mometasone furoate related to chronic obstructive pulmonary disease"" supported by the sentence: ""Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.""?",False, -10078337,Mometasone furoate related to perennial allergic rhinitis,2661,Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.,"Is the triple ""Mometasone furoate related to perennial allergic rhinitis"" supported by the sentence: ""Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.""?",False, -8366912,Mometasone furoate related to seasonal allergic rhinitis,2662,[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].,"Is the triple ""Mometasone furoate related to seasonal allergic rhinitis"" supported by the sentence: ""[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].""?",False, -15620377,Mometasone furoate affects asthma,2663,"Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).","Is the triple ""Mometasone furoate affects asthma"" supported by the sentence: ""Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).""?",False, -14474022,Mometasone furoate affects Nasal congestion,2664,CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.,"Is the triple ""Mometasone furoate affects Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.""?",False, -8375063,Mometasone furoate affects allergic rhinitis,2665,The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.,"Is the triple ""Mometasone furoate affects allergic rhinitis"" supported by the sentence: ""The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.""?",False, -17026384,Mometasone furoate prevents Nasal congestion,2666,CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.,"Is the triple ""Mometasone furoate prevents Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.""?",False, -15945486,Mometasone furoate prevents nasal cavity polyp,2667,Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.,"Is the triple ""Mometasone furoate prevents nasal cavity polyp"" supported by the sentence: ""Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.""?",False, -10581126,Methimazole related to hyperthyroidism,2668,Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.,"Is the triple ""Methimazole related to hyperthyroidism"" supported by the sentence: ""Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.""?",False, -8213703,Methimazole causes hyperthyroidism,2669,"These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.","Is the triple ""Methimazole causes hyperthyroidism"" supported by the sentence: ""These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.""?",False, -10543639,Methimazole affects hyperthyroidism,2670,Exacerbation of hyperthyroidism by methimazole during iodide therapy.,"Is the triple ""Methimazole affects hyperthyroidism"" supported by the sentence: ""Exacerbation of hyperthyroidism by methimazole during iodide therapy.""?",False, -25010771,Methimazole prevents hyperthyroidism,2671,"Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.","Is the triple ""Methimazole prevents hyperthyroidism"" supported by the sentence: ""Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.""?",False, -24946616,Safinamide physically interacts with Monoamine Oxidase B,2672,"Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.","Is the triple ""Safinamide physically interacts with Monoamine Oxidase B"" supported by the sentence: ""Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.""?",False, -19231919,Safinamide affects Parkinson disease,2673,"The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.","Is the triple ""Safinamide affects Parkinson disease"" supported by the sentence: ""The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.""?",False, -13464423,Safinamide affects Monoamine Oxidase B,2674,"A third agent with MAO-B inhibition properties, safinamide, is in phase III development.","Is the triple ""Safinamide affects Monoamine Oxidase B"" supported by the sentence: ""A third agent with MAO-B inhibition properties, safinamide, is in phase III development.""?",False, -25942595,Furosemide related to nephrotic syndrome,2675,[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].,"Is the triple ""Furosemide related to nephrotic syndrome"" supported by the sentence: ""[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].""?",False, -25824332,Furosemide related to Fibrosis,2676,Spironolactone and frusemide in cirrhosis with ascites.,"Is the triple ""Furosemide related to Fibrosis"" supported by the sentence: ""Spironolactone and frusemide in cirrhosis with ascites.""?",False, -25791999,Furosemide related to cirrhosis of liver,2677,[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].,"Is the triple ""Furosemide related to cirrhosis of liver"" supported by the sentence: ""[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].""?",False, -25414865,Furosemide related to syndromic disease,2678,"In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.","Is the triple ""Furosemide related to syndromic disease"" supported by the sentence: ""In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.""?",False, -24461287,Furosemide related to essential hypertension,2679,Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.,"Is the triple ""Furosemide related to essential hypertension"" supported by the sentence: ""Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.""?",False, -22834232,Furosemide related to type 2 diabetes mellitus,2680,The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.,"Is the triple ""Furosemide related to type 2 diabetes mellitus"" supported by the sentence: ""The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.""?",False, -19148228,Furosemide related to hypertensive disorder,2681,"A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.","Is the triple ""Furosemide related to hypertensive disorder"" supported by the sentence: ""A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.""?",False, -13031496,Furosemide related to acute kidney failure,2682,Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.,"Is the triple ""Furosemide related to acute kidney failure"" supported by the sentence: ""Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.""?",False, -8084093,Furosemide related to kidney failure,2683,"The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.","Is the triple ""Furosemide related to kidney failure"" supported by the sentence: ""The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.""?",False, -27482853,Furosemide causes Edema,2684,In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.,"Is the triple ""Furosemide causes Edema"" supported by the sentence: ""In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.""?",False, -27015887,Furosemide causes diabetes mellitus,2685,Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.,"Is the triple ""Furosemide causes diabetes mellitus"" supported by the sentence: ""Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.""?",False, -25990601,Furosemide causes hypertensive disorder,2686,[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].,"Is the triple ""Furosemide causes hypertensive disorder"" supported by the sentence: ""[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].""?",False, -25918508,Furosemide causes kidney disorder,2687,[Furosemide-induced nephropathy (author's transl)].,"Is the triple ""Furosemide causes kidney disorder"" supported by the sentence: ""[Furosemide-induced nephropathy (author's transl)].""?",False, -20167150,Furosemide causes syndromic disease,2688,"CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.","Is the triple ""Furosemide causes syndromic disease"" supported by the sentence: ""CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.""?",False, -19659078,Furosemide causes kidney failure,2689,"Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).","Is the triple ""Furosemide causes kidney failure"" supported by the sentence: ""Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).""?",False, -11605290,Furosemide causes nephrotic syndrome,2690,"Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.","Is the triple ""Furosemide causes nephrotic syndrome"" supported by the sentence: ""Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.""?",False, -9601857,Furosemide causes acute kidney failure,2691,"Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.","Is the triple ""Furosemide causes acute kidney failure"" supported by the sentence: ""Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.""?",False, -8252635,Furosemide causes Dyspnea,2692,Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.,"Is the triple ""Furosemide causes Dyspnea"" supported by the sentence: ""Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.""?",False, -26185017,Furosemide affects myocardial infarction,2693,Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.,"Is the triple ""Furosemide affects myocardial infarction"" supported by the sentence: ""Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.""?",False, -25909260,Furosemide affects nephrotic syndrome,2694,Plasma volume and effect of high dose frusemide in nephrotic syndrome.,"Is the triple ""Furosemide affects nephrotic syndrome"" supported by the sentence: ""Plasma volume and effect of high dose frusemide in nephrotic syndrome.""?",False, -22504977,Furosemide affects cirrhosis of liver,2695,"Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.","Is the triple ""Furosemide affects cirrhosis of liver"" supported by the sentence: ""Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.""?",False, -17729926,Furosemide affects Edema,2696,"Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.""?",False, -16155102,Furosemide affects kidney disorder,2697,"This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.","Is the triple ""Furosemide affects kidney disorder"" supported by the sentence: ""This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.""?",False, -15732141,Furosemide affects hypertensive disorder,2698,As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.,"Is the triple ""Furosemide affects hypertensive disorder"" supported by the sentence: ""As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.""?",False, -14935630,Furosemide affects kidney failure,2699,"In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.","Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.""?",False, -14887041,Furosemide affects acute kidney failure,2700,CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.""?",False, -14148250,Furosemide affects kidney failure,2701,OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.,"Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.""?",False, -13740455,Furosemide affects Dyspnea,2702,"Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.","Is the triple ""Furosemide affects Dyspnea"" supported by the sentence: ""Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.""?",False, -12836864,Furosemide affects Edema,2703,"BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.""?",False, -10718312,Furosemide affects diabetes mellitus,2704,[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].,"Is the triple ""Furosemide affects diabetes mellitus"" supported by the sentence: ""[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].""?",False, -8299615,Furosemide affects acute kidney failure,2705,Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.""?",False, -27482854,Furosemide disrupts Edema,2706,Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.,"Is the triple ""Furosemide disrupts Edema"" supported by the sentence: ""Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.""?",False, -19844878,Furosemide disrupts Dyspnea,2707,"At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.","Is the triple ""Furosemide disrupts Dyspnea"" supported by the sentence: ""At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.""?",False, -24717003,Furosemide prevents pulmonary edema,2708,"Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.","Is the triple ""Furosemide prevents pulmonary edema"" supported by the sentence: ""Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.""?",False, -22953098,Furosemide prevents Dyspnea,2709,"Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.","Is the triple ""Furosemide prevents Dyspnea"" supported by the sentence: ""Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.""?",False, -21527038,Furosemide prevents schizophrenia,2710,"Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.","Is the triple ""Furosemide prevents schizophrenia"" supported by the sentence: ""Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.""?",False, -20769925,Furosemide prevents bronchopulmonary dysplasia,2711,CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.,"Is the triple ""Furosemide prevents bronchopulmonary dysplasia"" supported by the sentence: ""CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.""?",False, -12415888,Furosemide prevents kidney disorder,2712,The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.,"Is the triple ""Furosemide prevents kidney disorder"" supported by the sentence: ""The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.""?",False, -11075685,Furosemide prevents hypertensive disorder,2713,"The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.","Is the triple ""Furosemide prevents hypertensive disorder"" supported by the sentence: ""The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.""?",False, -9165205,Furosemide prevents Edema,2714,Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.,"Is the triple ""Furosemide prevents Edema"" supported by the sentence: ""Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.""?",False, -8733555,Furosemide prevents syndromic disease,2715,"The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".","Is the triple ""Furosemide prevents syndromic disease"" supported by the sentence: ""The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".""?",False, -7901682,Furosemide prevents kidney failure,2716,"In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.","Is the triple ""Furosemide prevents kidney failure"" supported by the sentence: ""In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.""?",False, -24388792,Furosemide predisposes acute kidney failure,2717,Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?,"Is the triple ""Furosemide predisposes acute kidney failure"" supported by the sentence: ""Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?""?",False, -23800241,Furosemide predisposes myocardial infarction,2718,"METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).","Is the triple ""Furosemide predisposes myocardial infarction"" supported by the sentence: ""METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).""?",False, -21525697,Furosemide predisposes atherosclerosis,2719,"RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).","Is the triple ""Furosemide predisposes atherosclerosis"" supported by the sentence: ""RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).""?",False, -16660855,Furosemide predisposes kidney disorder,2720,"Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).","Is the triple ""Furosemide predisposes kidney disorder"" supported by the sentence: ""Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).""?",False, -19565633,Nabumetone physically interacts with Cyclooxygenase 2,2721,"The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.""?",False, -14176438,Nabumetone physically interacts with Cyclooxygenase 2,2722,"Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.""?",False, -15189827,Nabumetone affects osteoarthritis,2723,Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.,"Is the triple ""Nabumetone affects osteoarthritis"" supported by the sentence: ""Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.""?",False, -9219116,Nabumetone affects Cyclooxygenase 2,2724,"Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.","Is the triple ""Nabumetone affects Cyclooxygenase 2"" supported by the sentence: ""Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.""?",False, -11784119,Selegiline related to Parkinson disease,2725,Long-term experience with selegiline and levodopa in Parkinson's disease.,"Is the triple ""Selegiline related to Parkinson disease"" supported by the sentence: ""Long-term experience with selegiline and levodopa in Parkinson's disease.""?",False, -7091710,Selegiline related to Monoamine Oxidase B,2726,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, -7091710,Selegiline related to Monoamine Oxidase B,2727,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, -26670675,Selegiline coexists with Monoamine Oxidase B,2728,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, -26670675,Selegiline coexists with Monoamine Oxidase B,2729,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, -13016594,Selegiline physically interacts with Monoamine Oxidase B,2730,L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.,"Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.""?",False, -26762387,Selegiline physically interacts with Monoamine Oxidase B,2731,"MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.","Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.""?",False, -27251718,Selegiline causes depressive disorder,2732,These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.,"Is the triple ""Selegiline causes depressive disorder"" supported by the sentence: ""These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.""?",False, -18216942,Selegiline causes Parkinson disease,2733,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Selegiline causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, -8842901,Selegiline affects Parkinson disease,2734,Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.,"Is the triple ""Selegiline affects Parkinson disease"" supported by the sentence: ""Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.""?",False, -7091708,Selegiline affects Monoamine Oxidase B,2735,"In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.","Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.""?",False, -8615177,Selegiline affects Monoamine Oxidase B,2736,MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.,"Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.""?",False, -11022843,Selegiline disrupts Parkinson disease,2737,"Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.","Is the triple ""Selegiline disrupts Parkinson disease"" supported by the sentence: ""Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.""?",False, -8202759,Selegiline prevents depressive disorder,2738,"The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.","Is the triple ""Selegiline prevents depressive disorder"" supported by the sentence: ""The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.""?",False, -7205408,Selegiline prevents Parkinson disease,2739,Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.,"Is the triple ""Selegiline prevents Parkinson disease"" supported by the sentence: ""Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.""?",False, -21543223,Bumetanide causes pervasive developmental disorder,2740,This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.,"Is the triple ""Bumetanide causes pervasive developmental disorder"" supported by the sentence: ""This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.""?",False, -22325231,Bumetanide affects pervasive developmental disorder,2741,"Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).","Is the triple ""Bumetanide affects pervasive developmental disorder"" supported by the sentence: ""Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).""?",False, -20190253,Bumetanide affects autism spectrum disorder,2742,Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.,"Is the triple ""Bumetanide affects autism spectrum disorder"" supported by the sentence: ""Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.""?",False, -16914848,Bumetanide prevents autism spectrum disorder,2743,"UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.","Is the triple ""Bumetanide prevents autism spectrum disorder"" supported by the sentence: ""UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.""?",False, -11943751,D-Glucosamine related to breast neoplasm,2744,Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.,"Is the triple ""D-Glucosamine related to breast neoplasm"" supported by the sentence: ""Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.""?",False, -7809202,D-Glucosamine related to osteoarthritis,2745,Glucosamine in osteoarthritis.,"Is the triple ""D-Glucosamine related to osteoarthritis"" supported by the sentence: ""Glucosamine in osteoarthritis.""?",False, -27619077,D-Glucosamine causes obesity disorder,2746,"Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.","Is the triple ""D-Glucosamine causes obesity disorder"" supported by the sentence: ""Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.""?",False, -18633463,D-Glucosamine causes osteoarthritis,2747,Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.,"Is the triple ""D-Glucosamine causes osteoarthritis"" supported by the sentence: ""Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.""?",False, -9909825,D-Glucosamine affects osteoarthritis,2748,The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.,"Is the triple ""D-Glucosamine affects osteoarthritis"" supported by the sentence: ""The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.""?",False, -8968754,D-Glucosamine affects obesity disorder,2749,Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).,"Is the triple ""D-Glucosamine affects obesity disorder"" supported by the sentence: ""Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).""?",False, -13460623,D-Glucosamine disrupts osteoarthritis,2750,"Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.","Is the triple ""D-Glucosamine disrupts osteoarthritis"" supported by the sentence: ""Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.""?",False, -11817662,D-Glucosamine prevents osteoarthritis,2751,"OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.","Is the triple ""D-Glucosamine prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.""?",False, -25749858,Torsemide causes hypertensive disorder,2752,Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.,"Is the triple ""Torsemide causes hypertensive disorder"" supported by the sentence: ""Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.""?",False, -26478746,Torsemide affects hypertensive disorder,2753,"The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.","Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.""?",False, -13754465,Torsemide affects hypertensive disorder,2754,Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.,"Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.""?",False, -24478260,Leuprorelin related to infertility disorder,2755,Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.,"Is the triple ""Leuprorelin related to infertility disorder"" supported by the sentence: ""Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.""?",False, -22375547,Leuprorelin related to neoplasm,2756,"For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.","Is the triple ""Leuprorelin related to neoplasm"" supported by the sentence: ""For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.""?",False, -17696905,Leuprorelin related to leiomyoma,2757,"Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.","Is the triple ""Leuprorelin related to leiomyoma"" supported by the sentence: ""Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.""?",False, -16368292,Leuprorelin related to prostate cancer,2758,OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.,"Is the triple ""Leuprorelin related to prostate cancer"" supported by the sentence: ""OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.""?",False, -15413679,Leuprorelin related to endometriosis,2759,The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.,"Is the triple ""Leuprorelin related to endometriosis"" supported by the sentence: ""The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.""?",False, -9878755,Leuprorelin causes hypogonadism,2760,"Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.","Is the triple ""Leuprorelin causes hypogonadism"" supported by the sentence: ""Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.""?",False, -7418968,Leuprorelin causes neoplasm,2761,"In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.","Is the triple ""Leuprorelin causes neoplasm"" supported by the sentence: ""In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.""?",False, -27571709,Leuprorelin affects prostate cancer,2762,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, -27571708,Leuprorelin affects endometriosis,2763,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, -26547561,Leuprorelin affects endometriosis,2764,"Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.""?",False, -26152029,Leuprorelin affects prostate cancer,2765,Endocrine and clinical effects of leuprolide in prostatic cancer.,"Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""Endocrine and clinical effects of leuprolide in prostatic cancer.""?",False, -27542556,Leuprorelin prevents neoplasm,2766,In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.,"Is the triple ""Leuprorelin prevents neoplasm"" supported by the sentence: ""In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.""?",False, -12402472,Leuprorelin prevents Pain,2767,"CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.","Is the triple ""Leuprorelin prevents Pain"" supported by the sentence: ""CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.""?",False, -7814590,Sodium Bicarbonate subclass of Electrolytes,2768,"Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.","Is the triple ""Sodium Bicarbonate subclass of Electrolytes"" supported by the sentence: ""Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.""?",False, -26447678,Sodium Bicarbonate related to cystic fibrosis,2769,Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.,"Is the triple ""Sodium Bicarbonate related to cystic fibrosis"" supported by the sentence: ""Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.""?",False, -26270339,Sodium Bicarbonate related to kidney failure,2770,"Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.","Is the triple ""Sodium Bicarbonate related to kidney failure"" supported by the sentence: ""Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.""?",False, -20718850,Sodium Bicarbonate related to acidosis disorder,2771,There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.,"Is the triple ""Sodium Bicarbonate related to acidosis disorder"" supported by the sentence: ""There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.""?",False, -15047625,Sodium Bicarbonate related to Pain,2772,"We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.","Is the triple ""Sodium Bicarbonate related to Pain"" supported by the sentence: ""We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.""?",False, -14688492,Sodium Bicarbonate related to chronic renal failure syndrome,2773,"We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.","Is the triple ""Sodium Bicarbonate related to chronic renal failure syndrome"" supported by the sentence: ""We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.""?",False, -13166244,Sodium Bicarbonate related to kidney disorder,2774,REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.,"Is the triple ""Sodium Bicarbonate related to kidney disorder"" supported by the sentence: ""REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.""?",False, -12100581,Sodium Bicarbonate physically interacts with Electrolytes,2775,"NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.""?",False, -13772853,Sodium Bicarbonate physically interacts with Electrolytes,2776,"Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.""?",False, -27495118,Sodium Bicarbonate causes kidney failure,2777,"In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.","Is the triple ""Sodium Bicarbonate causes kidney failure"" supported by the sentence: ""In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.""?",False, -18327883,Sodium Bicarbonate causes kidney disorder,2778,This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.,"Is the triple ""Sodium Bicarbonate causes kidney disorder"" supported by the sentence: ""This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.""?",False, -14549296,Sodium Bicarbonate causes injury,2779,Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.,"Is the triple ""Sodium Bicarbonate causes injury"" supported by the sentence: ""Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.""?",False, -8914995,Sodium Bicarbonate causes acidosis disorder,2780,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate causes acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, -25712033,Sodium Bicarbonate affects Abnormality of acid-base homeostasis,2781,An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.,"Is the triple ""Sodium Bicarbonate affects Abnormality of acid-base homeostasis"" supported by the sentence: ""An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.""?",False, -18411502,Sodium Bicarbonate affects injury,2782,OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.,"Is the triple ""Sodium Bicarbonate affects injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.""?",False, -17654743,Sodium Bicarbonate affects kidney disorder,2783,"Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.","Is the triple ""Sodium Bicarbonate affects kidney disorder"" supported by the sentence: ""Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.""?",False, -12960490,Sodium Bicarbonate affects Pain,2784,Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.,"Is the triple ""Sodium Bicarbonate affects Pain"" supported by the sentence: ""Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.""?",False, -8914994,Sodium Bicarbonate affects acidosis disorder,2785,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate affects acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, -14651482,Sodium Bicarbonate disrupts acidosis disorder,2786,"The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.","Is the triple ""Sodium Bicarbonate disrupts acidosis disorder"" supported by the sentence: ""The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.""?",False, -21103228,Sodium Bicarbonate prevents acidosis disorder,2787,According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.,"Is the triple ""Sodium Bicarbonate prevents acidosis disorder"" supported by the sentence: ""According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.""?",False, -13938650,Sodium Bicarbonate prevents injury,2788,Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.,"Is the triple ""Sodium Bicarbonate prevents injury"" supported by the sentence: ""Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.""?",False, -11746267,Sodium Bicarbonate prevents kidney failure,2789,"SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.","Is the triple ""Sodium Bicarbonate prevents kidney failure"" supported by the sentence: ""SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.""?",False, -11205688,Sodium Bicarbonate prevents acute kidney failure,2790,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Bicarbonate prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, -11205686,Sodium Bicarbonate prevents kidney disorder,2791,Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.,"Is the triple ""Sodium Bicarbonate prevents kidney disorder"" supported by the sentence: ""Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.""?",False, -14663272,Sodium Bicarbonate predisposes kidney disorder,2792,PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.,"Is the triple ""Sodium Bicarbonate predisposes kidney disorder"" supported by the sentence: ""PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.""?",False, -14542214,Sodium Bicarbonate predisposes injury,2793,"We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.","Is the triple ""Sodium Bicarbonate predisposes injury"" supported by the sentence: ""We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.""?",False, -17530350,Olmesartan medoxomil affects diabetic kidney disease,2794,Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.,"Is the triple ""Olmesartan medoxomil affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.""?",False, -12894557,Olmesartan medoxomil affects atherosclerosis,2795,Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.,"Is the triple ""Olmesartan medoxomil affects atherosclerosis"" supported by the sentence: ""Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.""?",False, -12254737,Olmesartan medoxomil affects diabetes mellitus,2796,A further evaluation of the effects of OM in diabetes is warranted.,"Is the triple ""Olmesartan medoxomil affects diabetes mellitus"" supported by the sentence: ""A further evaluation of the effects of OM in diabetes is warranted.""?",False, -15583038,Olmesartan medoxomil disrupts hypertensive disorder,2797,"Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.","Is the triple ""Olmesartan medoxomil disrupts hypertensive disorder"" supported by the sentence: ""Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.""?",False, -12254736,Olmesartan medoxomil disrupts proteinuria,2798,"These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).","Is the triple ""Olmesartan medoxomil disrupts proteinuria"" supported by the sentence: ""These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).""?",False, -12254735,Olmesartan medoxomil prevents hypertensive disorder,2799,"At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.","Is the triple ""Olmesartan medoxomil prevents hypertensive disorder"" supported by the sentence: ""At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.""?",False, -9359700,Olmesartan medoxomil prevents atherosclerosis,2800,This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.,"Is the triple ""Olmesartan medoxomil prevents atherosclerosis"" supported by the sentence: ""This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.""?",False, -8752749,Candesartan related to essential hypertension,2801,Comparison of candesartan versus enalapril in essential hypertension.,"Is the triple ""Candesartan related to essential hypertension"" supported by the sentence: ""Comparison of candesartan versus enalapril in essential hypertension.""?",False, -20752265,Candesartan causes Cognitive impairment,2802,"Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.","Is the triple ""Candesartan causes Cognitive impairment"" supported by the sentence: ""Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.""?",False, -14838058,Candesartan causes hypertensive disorder,2803,"Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.","Is the triple ""Candesartan causes hypertensive disorder"" supported by the sentence: ""Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.""?",False, -20512666,Candesartan affects Cognitive impairment,2804,"We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.""?",False, -20051167,Candesartan affects hypertensive disorder,2805,"Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.""?",False, -19501045,Candesartan affects Cognitive impairment,2806,"METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.""?",False, -14118850,Candesartan affects Left ventricular hypertrophy,2807,"The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.","Is the triple ""Candesartan affects Left ventricular hypertrophy"" supported by the sentence: ""The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.""?",False, -9919312,Candesartan affects hypertensive disorder,2808,"RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).""?",False, -14542524,Candesartan disrupts Left ventricular hypertrophy,2809,"A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.","Is the triple ""Candesartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.""?",False, -9479295,Candesartan disrupts hypertensive disorder,2810,Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.,"Is the triple ""Candesartan disrupts hypertensive disorder"" supported by the sentence: ""Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.""?",False, -24756017,Candesartan prevents Cognitive impairment,2811,"Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.","Is the triple ""Candesartan prevents Cognitive impairment"" supported by the sentence: ""Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.""?",False, -15502429,Candesartan prevents cardiovascular disorder,2812,"The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).","Is the triple ""Candesartan prevents cardiovascular disorder"" supported by the sentence: ""The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).""?",False, -12994289,Candesartan prevents Left ventricular hypertrophy,2813,"Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.","Is the triple ""Candesartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.""?",False, -12444324,Candesartan prevents atrial fibrillation,2814,"CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.","Is the triple ""Candesartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.""?",False, -12421723,Candesartan prevents migraine disorder,2815,"CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.","Is the triple ""Candesartan prevents migraine disorder"" supported by the sentence: ""CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.""?",False, -8787605,Candesartan prevents hypertensive disorder,2816,"When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.","Is the triple ""Candesartan prevents hypertensive disorder"" supported by the sentence: ""When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.""?",False, -9420113,Telmisartan related to diabetes mellitus,2817,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to diabetes mellitus"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, -9420112,Telmisartan related to hypertensive disorder,2818,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to hypertensive disorder"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, -16669618,Telmisartan causes cardiovascular disorder,2819,These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.,"Is the triple ""Telmisartan causes cardiovascular disorder"" supported by the sentence: ""These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.""?",False, -16637024,Telmisartan causes hypertensive disorder,2820,Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.,"Is the triple ""Telmisartan causes hypertensive disorder"" supported by the sentence: ""Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.""?",False, -16559226,Telmisartan causes myocardial infarction,2821,"Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.","Is the triple ""Telmisartan causes myocardial infarction"" supported by the sentence: ""Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.""?",False, -14418892,Telmisartan causes Albuminuria,2822,CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.,"Is the triple ""Telmisartan causes Albuminuria"" supported by the sentence: ""CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.""?",False, -13301662,Telmisartan causes diabetes mellitus,2823,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Telmisartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, -20835589,Telmisartan affects diabetic kidney disease,2824,This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.,"Is the triple ""Telmisartan affects diabetic kidney disease"" supported by the sentence: ""This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.""?",False, -17882285,Telmisartan affects Albuminuria,2825,"Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.""?",False, -16266744,Telmisartan affects Albuminuria,2826,Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.,"Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.""?",False, -15802746,Telmisartan affects diabetes mellitus,2827,"Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.""?",False, -13992848,Telmisartan affects diabetes mellitus,2828,"Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.""?",False, -13861721,Telmisartan affects type 2 diabetes mellitus,2829,Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.,"Is the triple ""Telmisartan affects type 2 diabetes mellitus"" supported by the sentence: ""Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.""?",False, -13824093,Telmisartan affects Albuminuria,2830,"An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.""?",False, -13501012,Telmisartan affects essential hypertension,2831,CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.,"Is the triple ""Telmisartan affects essential hypertension"" supported by the sentence: ""CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.""?",False, -13178302,Telmisartan affects hypertensive disorder,2832,"In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.","Is the triple ""Telmisartan affects hypertensive disorder"" supported by the sentence: ""In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.""?",False, -25051574,Telmisartan disrupts Alzheimer disease,2833,"RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).","Is the triple ""Telmisartan disrupts Alzheimer disease"" supported by the sentence: ""RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).""?",False, -14418891,Telmisartan disrupts Albuminuria,2834,RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.,"Is the triple ""Telmisartan disrupts Albuminuria"" supported by the sentence: ""RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.""?",False, -13325686,Telmisartan disrupts hypertensive disorder,2835,"WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.","Is the triple ""Telmisartan disrupts hypertensive disorder"" supported by the sentence: ""WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.""?",False, -21182197,Telmisartan prevents Alzheimer disease,2836,Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.,"Is the triple ""Telmisartan prevents Alzheimer disease"" supported by the sentence: ""Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.""?",False, -17513403,Telmisartan prevents myocardial infarction,2837,This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.,"Is the triple ""Telmisartan prevents myocardial infarction"" supported by the sentence: ""This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.""?",False, -17170882,Telmisartan prevents type 2 diabetes mellitus,2838,"OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).","Is the triple ""Telmisartan prevents type 2 diabetes mellitus"" supported by the sentence: ""OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).""?",False, -13010398,Telmisartan prevents stroke disorder,2839,"The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.","Is the triple ""Telmisartan prevents stroke disorder"" supported by the sentence: ""The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.""?",False, -12278433,Telmisartan prevents diabetic kidney disease,2840,"In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.","Is the triple ""Telmisartan prevents diabetic kidney disease"" supported by the sentence: ""In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.""?",False, -11585228,Telmisartan prevents diabetes mellitus,2841,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents diabetes mellitus"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, -11585227,Telmisartan prevents cardiovascular disorder,2842,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents cardiovascular disorder"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, -11473935,Telmisartan prevents hypertensive disorder,2843,"In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.","Is the triple ""Telmisartan prevents hypertensive disorder"" supported by the sentence: ""In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.""?",False, -17028323,Telmisartan predisposes stroke disorder,2844,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes stroke disorder"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, -17028322,Telmisartan predisposes myocardial infarction,2845,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes myocardial infarction"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, -21651336,Irbesartan causes hypertensive disorder,2846,"The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.","Is the triple ""Irbesartan causes hypertensive disorder"" supported by the sentence: ""The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.""?",False, -19454247,Irbesartan affects Sepsis,2847,Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.,"Is the triple ""Irbesartan affects Sepsis"" supported by the sentence: ""Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.""?",False, -13143483,Irbesartan affects type 2 diabetes mellitus,2848,CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.,"Is the triple ""Irbesartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.""?",False, -9015828,Irbesartan affects chronic kidney disease,2849,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects chronic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, -9015827,Irbesartan affects diabetic kidney disease,2850,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects diabetic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, -7812861,Irbesartan affects acute kidney failure,2851,[Acute renal failure associated with irbesartan].,"Is the triple ""Irbesartan affects acute kidney failure"" supported by the sentence: ""[Acute renal failure associated with irbesartan].""?",False, -19016605,Irbesartan disrupts atrial fibrillation,2852,Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.,"Is the triple ""Irbesartan disrupts atrial fibrillation"" supported by the sentence: ""Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.""?",False, -11936096,Irbesartan disrupts hypertensive disorder,2853,"Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.","Is the triple ""Irbesartan disrupts hypertensive disorder"" supported by the sentence: ""Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.""?",False, -9297339,Irbesartan disrupts diabetic kidney disease,2854,Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.,"Is the triple ""Irbesartan disrupts diabetic kidney disease"" supported by the sentence: ""Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.""?",False, -11467158,Irbesartan prevents chronic kidney disease,2855,"In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.","Is the triple ""Irbesartan prevents chronic kidney disease"" supported by the sentence: ""In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.""?",False, -9856662,Irbesartan prevents diabetic kidney disease,2856,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Irbesartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, -8753962,Irbesartan prevents hypertensive disorder,2857,Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.,"Is the triple ""Irbesartan prevents hypertensive disorder"" supported by the sentence: ""Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.""?",False, -15497727,Irbesartan predisposes cardiovascular disorder,2858,"PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.","Is the triple ""Irbesartan predisposes cardiovascular disorder"" supported by the sentence: ""PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.""?",False, -12041301,Irbesartan predisposes IgA glomerulonephritis,2859,OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.,"Is the triple ""Irbesartan predisposes IgA glomerulonephritis"" supported by the sentence: ""OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.""?",False, -9459261,Eprosartan related to essential hypertension,2860,Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.,"Is the triple ""Eprosartan related to essential hypertension"" supported by the sentence: ""Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.""?",False, -8111433,Valsartan related to essential hypertension,2861,"While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.","Is the triple ""Valsartan related to essential hypertension"" supported by the sentence: ""While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.""?",False, -18505936,Valsartan causes myocardial infarction,2862,Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.,"Is the triple ""Valsartan causes myocardial infarction"" supported by the sentence: ""Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.""?",False, -13301661,Valsartan causes diabetes mellitus,2863,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Valsartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, -18533693,Valsartan affects hypertensive disorder,2864,"TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.","Is the triple ""Valsartan affects hypertensive disorder"" supported by the sentence: ""TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.""?",False, -18130226,Valsartan affects stroke disorder,2865,"We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.","Is the triple ""Valsartan affects stroke disorder"" supported by the sentence: ""We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.""?",False, -16609149,Valsartan affects kidney disorder,2866,"This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.","Is the triple ""Valsartan affects kidney disorder"" supported by the sentence: ""This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.""?",False, -9837968,Valsartan affects Abnormal left ventricular function,2867,Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.,"Is the triple ""Valsartan affects Abnormal left ventricular function"" supported by the sentence: ""Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.""?",False, -15479686,Valsartan disrupts type 2 diabetes mellitus,2868,These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.,"Is the triple ""Valsartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.""?",False, -11438135,Valsartan disrupts atherosclerosis,2869,"Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.","Is the triple ""Valsartan disrupts atherosclerosis"" supported by the sentence: ""Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.""?",False, -20671333,Valsartan prevents Abnormal left ventricular function,2870,"CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.","Is the triple ""Valsartan prevents Abnormal left ventricular function"" supported by the sentence: ""CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.""?",False, -15012324,Valsartan prevents type 2 diabetes mellitus,2871,"In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.","Is the triple ""Valsartan prevents type 2 diabetes mellitus"" supported by the sentence: ""In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.""?",False, -13899819,Valsartan prevents stroke disorder,2872,"Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.","Is the triple ""Valsartan prevents stroke disorder"" supported by the sentence: ""Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.""?",False, -12374506,Valsartan prevents diabetes mellitus,2873,"Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.","Is the triple ""Valsartan prevents diabetes mellitus"" supported by the sentence: ""Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.""?",False, -12038680,Valsartan prevents myocardial infarction,2874,"For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.","Is the triple ""Valsartan prevents myocardial infarction"" supported by the sentence: ""For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.""?",False, -11801448,Valsartan prevents atrial fibrillation,2875,CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.,"Is the triple ""Valsartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.""?",False, -8617185,Valsartan prevents coronary artery disorder,2876,"Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.","Is the triple ""Valsartan prevents coronary artery disorder"" supported by the sentence: ""Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.""?",False, -7691192,Valsartan prevents hypertensive disorder,2877,"Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.","Is the triple ""Valsartan prevents hypertensive disorder"" supported by the sentence: ""Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.""?",False, -7604460,Valsartan prevents atherosclerosis,2878,CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.,"Is the triple ""Valsartan prevents atherosclerosis"" supported by the sentence: ""CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.""?",False, -21524148,Valsartan predisposes myocardial infarction,2879,"Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).","Is the triple ""Valsartan predisposes myocardial infarction"" supported by the sentence: ""Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).""?",False, -11133518,Valsartan predisposes cardiovascular disorder,2880,"Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.","Is the triple ""Valsartan predisposes cardiovascular disorder"" supported by the sentence: ""Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.""?",False, -13065808,Losartan related to non-alcoholic fatty liver disease,2881,"AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.","Is the triple ""Losartan related to non-alcoholic fatty liver disease"" supported by the sentence: ""AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.""?",False, -12094342,Losartan related to proteinuria,2882,"The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.","Is the triple ""Losartan related to proteinuria"" supported by the sentence: ""The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.""?",False, -11472713,Losartan related to kidney disorder,2883,Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.,"Is the triple ""Losartan related to kidney disorder"" supported by the sentence: ""Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.""?",False, -10013644,Losartan related to hypertensive disorder,2884,"OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.","Is the triple ""Losartan related to hypertensive disorder"" supported by the sentence: ""OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.""?",False, -8975375,Losartan related to IgA glomerulonephritis,2885,Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.,"Is the triple ""Losartan related to IgA glomerulonephritis"" supported by the sentence: ""Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.""?",False, -16215194,Losartan causes injury,2886,"METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.","Is the triple ""Losartan causes injury"" supported by the sentence: ""METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.""?",False, -15690681,Losartan causes kidney disorder,2887,"Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.","Is the triple ""Losartan causes kidney disorder"" supported by the sentence: ""Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.""?",False, -9749061,Losartan causes hypertensive disorder,2888,Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.,"Is the triple ""Losartan causes hypertensive disorder"" supported by the sentence: ""Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.""?",False, -7310301,Losartan causes proteinuria,2889,"In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.","Is the triple ""Losartan causes proteinuria"" supported by the sentence: ""In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.""?",False, -7204638,Losartan causes Left ventricular hypertrophy,2890,The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.,"Is the triple ""Losartan causes Left ventricular hypertrophy"" supported by the sentence: ""The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.""?",False, -26608778,Losartan affects essential hypertension,2891,The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.,"Is the triple ""Losartan affects essential hypertension"" supported by the sentence: ""The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.""?",False, -24425437,Losartan affects cystic fibrosis,2892,Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.,"Is the triple ""Losartan affects cystic fibrosis"" supported by the sentence: ""Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.""?",False, -21888728,Losartan affects proteinuria,2893,"Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.""?",False, -20488125,Losartan affects hypertensive disorder,2894,"The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.","Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.""?",False, -19990804,Losartan affects aortic valve insufficiency,2895,Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.,"Is the triple ""Losartan affects aortic valve insufficiency"" supported by the sentence: ""Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.""?",False, -18707849,Losartan affects hypertrophic cardiomyopathy,2896,Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.,"Is the triple ""Losartan affects hypertrophic cardiomyopathy"" supported by the sentence: ""Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.""?",False, -16976701,Losartan affects IgA glomerulonephritis,2897,CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.,"Is the triple ""Losartan affects IgA glomerulonephritis"" supported by the sentence: ""CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.""?",False, -13986638,Losartan affects adult acute respiratory distress syndrome,2898,This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.,"Is the triple ""Losartan affects adult acute respiratory distress syndrome"" supported by the sentence: ""This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.""?",False, -13539739,Losartan affects proteinuria,2899,"Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.""?",False, -13498248,Losartan affects Inflammation,2900,"Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.","Is the triple ""Losartan affects Inflammation"" supported by the sentence: ""Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.""?",False, -12531070,Losartan affects Left ventricular hypertrophy,2901,Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.,"Is the triple ""Losartan affects Left ventricular hypertrophy"" supported by the sentence: ""Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.""?",False, -10809955,Losartan affects hypertensive disorder,2902,Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).,"Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).""?",False, -9615315,Losartan affects diabetic kidney disease,2903,Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?,"Is the triple ""Losartan affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?""?",False, -9459571,Losartan affects type 2 diabetes mellitus,2904,CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.""?",False, -9229634,Losartan affects kidney disorder,2905,Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.,"Is the triple ""Losartan affects kidney disorder"" supported by the sentence: ""Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.""?",False, -8678480,Losartan affects injury,2906,"Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.","Is the triple ""Losartan affects injury"" supported by the sentence: ""Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.""?",False, -8551167,Losartan affects type 2 diabetes mellitus,2907,METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.""?",False, -18715311,Losartan disrupts breast neoplasm,2908,"In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.","Is the triple ""Losartan disrupts breast neoplasm"" supported by the sentence: ""In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.""?",False, -14458903,Losartan disrupts pancreatic neoplasm,2909,"When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.","Is the triple ""Losartan disrupts pancreatic neoplasm"" supported by the sentence: ""When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.""?",False, -13976332,Losartan disrupts diabetic kidney disease,2910,OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.,"Is the triple ""Losartan disrupts diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.""?",False, -12949848,Losartan disrupts Inflammation,2911,"Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.","Is the triple ""Losartan disrupts Inflammation"" supported by the sentence: ""Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.""?",False, -9870082,Losartan disrupts hypertensive disorder,2912,Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).,"Is the triple ""Losartan disrupts hypertensive disorder"" supported by the sentence: ""Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).""?",False, -9655766,Losartan disrupts type 2 diabetes mellitus,2913,"Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.","Is the triple ""Losartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.""?",False, -8325352,Losartan disrupts Left ventricular hypertrophy,2914,"Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.","Is the triple ""Losartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.""?",False, -7975855,Losartan disrupts injury,2915,Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.,"Is the triple ""Losartan disrupts injury"" supported by the sentence: ""Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.""?",False, -7310299,Losartan disrupts proteinuria,2916,"CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.","Is the triple ""Losartan disrupts proteinuria"" supported by the sentence: ""CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.""?",False, -21356716,Losartan prevents post-traumatic stress disorder,2917,"We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.","Is the triple ""Losartan prevents post-traumatic stress disorder"" supported by the sentence: ""We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.""?",False, -14540327,Losartan prevents kidney disorder,2918,BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.,"Is the triple ""Losartan prevents kidney disorder"" supported by the sentence: ""BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.""?",False, -12407992,Losartan prevents Inflammation,2919,"RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.","Is the triple ""Losartan prevents Inflammation"" supported by the sentence: ""RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.""?",False, -10030687,Losartan prevents cardiovascular disorder,2920,Losartan vs atenolol in prevention of stroke and cardiovascular disease.,"Is the triple ""Losartan prevents cardiovascular disorder"" supported by the sentence: ""Losartan vs atenolol in prevention of stroke and cardiovascular disease.""?",False, -9856661,Losartan prevents diabetic kidney disease,2921,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Losartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, -9773800,Losartan prevents Left ventricular hypertrophy,2922,Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.,"Is the triple ""Losartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.""?",False, -9766007,Losartan prevents adult acute respiratory distress syndrome,2923,"Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.","Is the triple ""Losartan prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.""?",False, -9420091,Losartan prevents Stenosis,2924,The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.,"Is the triple ""Losartan prevents Stenosis"" supported by the sentence: ""The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.""?",False, -9077908,Losartan prevents proteinuria,2925,"Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.","Is the triple ""Losartan prevents proteinuria"" supported by the sentence: ""Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.""?",False, -8542944,Losartan prevents injury,2926,Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.,"Is the triple ""Losartan prevents injury"" supported by the sentence: ""Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.""?",False, -7768196,Losartan prevents hypertensive disorder,2927,"RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.","Is the triple ""Losartan prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.""?",False, -14272023,Losartan predisposes kidney disorder,2928,"Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.","Is the triple ""Losartan predisposes kidney disorder"" supported by the sentence: ""Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.""?",False, -12616336,Losartan predisposes cardiovascular disorder,2929,"Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.","Is the triple ""Losartan predisposes cardiovascular disorder"" supported by the sentence: ""Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.""?",False, -9964252,Losartan predisposes Left ventricular hypertrophy,2930,"In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).","Is the triple ""Losartan predisposes Left ventricular hypertrophy"" supported by the sentence: ""In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).""?",False, -20586471,Dronabinol related to multiple sclerosis,2931,A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.,"Is the triple ""Dronabinol related to multiple sclerosis"" supported by the sentence: ""A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.""?",False, -25459397,Dronabinol causes cannabis dependence,2932,"BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.","Is the triple ""Dronabinol causes cannabis dependence"" supported by the sentence: ""BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.""?",False, -22027243,Dronabinol causes Nausea,2933,"CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.","Is the triple ""Dronabinol causes Nausea"" supported by the sentence: ""CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.""?",False, -17252204,Dronabinol causes schizophrenia,2934,"Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.","Is the triple ""Dronabinol causes schizophrenia"" supported by the sentence: ""Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.""?",False, -12205989,Dronabinol causes Cognitive impairment,2935,"Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.","Is the triple ""Dronabinol causes Cognitive impairment"" supported by the sentence: ""Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.""?",False, -27448088,Dronabinol affects Anorexia,2936,Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.,"Is the triple ""Dronabinol affects Anorexia"" supported by the sentence: ""Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.""?",False, -25890458,Dronabinol affects Nausea,2937,"Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.","Is the triple ""Dronabinol affects Nausea"" supported by the sentence: ""Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.""?",False, -21879717,Dronabinol affects anorexia nervosa,2938,"The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.","Is the triple ""Dronabinol affects anorexia nervosa"" supported by the sentence: ""The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.""?",False, -20855895,Dronabinol affects neoplasm,2939,"Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.","Is the triple ""Dronabinol affects neoplasm"" supported by the sentence: ""Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.""?",False, -19991701,Dronabinol affects obstructive sleep apnea syndrome,2940,"Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.","Is the triple ""Dronabinol affects obstructive sleep apnea syndrome"" supported by the sentence: ""Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.""?",False, -19474044,Dronabinol affects multiple sclerosis,2941,Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.,"Is the triple ""Dronabinol affects multiple sclerosis"" supported by the sentence: ""Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.""?",False, -16547908,Dronabinol affects schizophrenia,2942,"CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.""?",False, -14443952,Dronabinol affects opiate dependence,2943,Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.,"Is the triple ""Dronabinol affects opiate dependence"" supported by the sentence: ""Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.""?",False, -13958866,Dronabinol affects Cognitive impairment,2944,"Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.","Is the triple ""Dronabinol affects Cognitive impairment"" supported by the sentence: ""Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.""?",False, -13933776,Dronabinol affects schizophrenia,2945,"This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.""?",False, -11304843,Dronabinol affects neuralgia,2946,OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.,"Is the triple ""Dronabinol affects neuralgia"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.""?",False, -11058493,Dronabinol affects Pain,2947,"THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.","Is the triple ""Dronabinol affects Pain"" supported by the sentence: ""THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.""?",False, -24013541,Dronabinol disrupts Pain,2948,"Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.","Is the triple ""Dronabinol disrupts Pain"" supported by the sentence: ""Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.""?",False, -17477155,Dronabinol disrupts HIV infectious disease,2949,"Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.","Is the triple ""Dronabinol disrupts HIV infectious disease"" supported by the sentence: ""Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.""?",False, -11615857,Dronabinol disrupts Nausea,2950,"The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.","Is the triple ""Dronabinol disrupts Nausea"" supported by the sentence: ""The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.""?",False, -25196408,Dronabinol prevents dementia,2951,Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.,"Is the triple ""Dronabinol prevents dementia"" supported by the sentence: ""Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.""?",False, -25026370,Dronabinol prevents neuralgia,2952,We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.,"Is the triple ""Dronabinol prevents neuralgia"" supported by the sentence: ""We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.""?",False, -18579580,Dronabinol prevents Postoperative Nausea and Vomiting,2953,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, -18554637,Dronabinol prevents Nausea,2954,"However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.","Is the triple ""Dronabinol prevents Nausea"" supported by the sentence: ""However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.""?",False, -17477149,Dronabinol prevents HIV infectious disease,2955,THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.,"Is the triple ""Dronabinol prevents HIV infectious disease"" supported by the sentence: ""THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.""?",False, -9671016,Dronabinol prevents Pain,2956,"There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.","Is the triple ""Dronabinol prevents Pain"" supported by the sentence: ""There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.""?",False, -22976957,Dronabinol predisposes Cognitive impairment,2957,"The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.","Is the triple ""Dronabinol predisposes Cognitive impairment"" supported by the sentence: ""The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.""?",False, -18579581,Dronabinol predisposes Postoperative Nausea and Vomiting,2958,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol predisposes Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, -26722658,Cesamet affects Postoperative Nausea and Vomiting,2959,"In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).","Is the triple ""Cesamet affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).""?",False, -26699974,Cesamet affects Nausea,2960,Effect of nabilone on nausea and vomiting.,"Is the triple ""Cesamet affects Nausea"" supported by the sentence: ""Effect of nabilone on nausea and vomiting.""?",False, -19460580,Cesamet prevents Postoperative Nausea and Vomiting,2961,METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.,"Is the triple ""Cesamet prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.""?",False, -25552574,Aprepitant related to glioblastoma,2962,"The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.","Is the triple ""Aprepitant related to glioblastoma"" supported by the sentence: ""The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.""?",False, -18054447,Aprepitant related to Vomiting,2963,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Vomiting"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, -18054446,Aprepitant related to Nausea,2964,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Nausea"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, -11788538,Aprepitant causes Vomiting,2965,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Vomiting"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, -11788537,Aprepitant causes Nausea,2966,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Nausea"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, -23692862,Aprepitant affects Nausea,2967,"The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.","Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.""?",False, -19750085,Aprepitant affects Postoperative Nausea and Vomiting,2968,"In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.","Is the triple ""Aprepitant affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.""?",False, -17874842,Aprepitant affects Vomiting,2969,"Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.","Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.""?",False, -12562288,Aprepitant affects Nausea,2970,Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.,"Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.""?",False, -11119543,Aprepitant affects Vomiting,2971,Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.,"Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.""?",False, -19013645,Aprepitant disrupts HIV infectious disease,2972,RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.,"Is the triple ""Aprepitant disrupts HIV infectious disease"" supported by the sentence: ""RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.""?",False, -16125731,Aprepitant disrupts Vomiting,2973,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Vomiting"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, -16125730,Aprepitant disrupts Nausea,2974,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Nausea"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, -16513148,Aprepitant prevents Pruritus,2975,"INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.","Is the triple ""Aprepitant prevents Pruritus"" supported by the sentence: ""INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.""?",False, -15868137,Aprepitant prevents Postoperative Nausea and Vomiting,2976,We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.,"Is the triple ""Aprepitant prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.""?",False, -10160541,Aprepitant prevents Vomiting,2977,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Vomiting"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, -10160540,Aprepitant prevents Nausea,2978,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Nausea"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, -20804596,Aprepitant predisposes Nausea,2979,"CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.","Is the triple ""Aprepitant predisposes Nausea"" supported by the sentence: ""CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.""?",False, -22122089,Neratinib affects neoplasm,2980,The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].,"Is the triple ""Neratinib affects neoplasm"" supported by the sentence: ""The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].""?",False, -21597229,Lapatinib related to neoplasm,2981,"Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.","Is the triple ""Lapatinib related to neoplasm"" supported by the sentence: ""Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.""?",False, -13650844,Lapatinib related to non-small cell lung carcinoma,2982,"In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.","Is the triple ""Lapatinib related to non-small cell lung carcinoma"" supported by the sentence: ""In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.""?",False, -18268107,Lapatinib affects neoplasm,2983,Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.,"Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.""?",False, -15442238,Lapatinib affects breast neoplasm,2984,HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.,"Is the triple ""Lapatinib affects breast neoplasm"" supported by the sentence: ""HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.""?",False, -14691634,Lapatinib affects neoplasm,2985,"However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.","Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.""?",False, -17546445,Lapatinib disrupts neoplasm,2986,"Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.","Is the triple ""Lapatinib disrupts neoplasm"" supported by the sentence: ""Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.""?",False, -19410918,Lapatinib prevents breast neoplasm,2987,"Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.","Is the triple ""Lapatinib prevents breast neoplasm"" supported by the sentence: ""Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.""?",False, -19317295,Lapatinib prevents neoplasm,2988,CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.,"Is the triple ""Lapatinib prevents neoplasm"" supported by the sentence: ""CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.""?",False, -16643911,Lapatinib predisposes neoplasm,2989,"We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.","Is the triple ""Lapatinib predisposes neoplasm"" supported by the sentence: ""We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.""?",False, -24360220,Nifurtimox related to human African trypanosomiasis,2990,Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.,"Is the triple ""Nifurtimox related to human African trypanosomiasis"" supported by the sentence: ""Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.""?",False, -25977066,Nifurtimox coexists with Deoxyribonucleic acid,2991,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, -25977066,Nifurtimox coexists with Deoxyribonucleic acid,2992,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, -25822629,Nifurtimox causes Chagas disease,2993,Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.,"Is the triple ""Nifurtimox causes Chagas disease"" supported by the sentence: ""Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.""?",False, -21140520,Nifurtimox affects neuroblastoma,2994,"Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.","Is the triple ""Nifurtimox affects neuroblastoma"" supported by the sentence: ""Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.""?",False, -19390598,Nifurtimox affects trypanosomiasis,2995,"The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.","Is the triple ""Nifurtimox affects trypanosomiasis"" supported by the sentence: ""The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.""?",False, -18236131,Nifurtimox affects Deoxyribonucleic acid,2996,"Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).","Is the triple ""Nifurtimox affects Deoxyribonucleic acid"" supported by the sentence: ""Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).""?",False, -21140519,Nifurtimox disrupts neuroblastoma,2997,"Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.","Is the triple ""Nifurtimox disrupts neuroblastoma"" supported by the sentence: ""Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.""?",False, -16729888,Nifurtimox prevents Chagas disease,2998,"Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.","Is the triple ""Nifurtimox prevents Chagas disease"" supported by the sentence: ""Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.""?",False, -8359719,Nitrofurazone coexists with Deoxyribonucleic acid,2999,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, -8359719,Nitrofurazone coexists with Deoxyribonucleic acid,3000,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, -21506050,Nitrofurazone physically interacts with Deoxyribonucleic acid,3001,"Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.""?",False, -16350865,Nitrofurazone physically interacts with Deoxyribonucleic acid,3002,"In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.""?",False, -26982963,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3003,The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.""?",False, -14891197,SCOPOLAMINE HYDROBROMIDE affects Pain,3004,Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Pain"" supported by the sentence: ""Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.""?",False, -13216168,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3005,The effects of scopolamine on MS were studied in mice and rats.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The effects of scopolamine on MS were studied in mice and rats.""?",False, -9844335,SCOPOLAMINE HYDROBROMIDE affects Drooling,3006,"CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.","Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Drooling"" supported by the sentence: ""CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.""?",False, -11447618,SCOPOLAMINE HYDROBROMIDE prevents Pain,3007,In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Pain"" supported by the sentence: ""In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.""?",False, -11253841,SCOPOLAMINE HYDROBROMIDE prevents Drooling,3008,"Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.","Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Drooling"" supported by the sentence: ""Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.""?",False, -8806634,SCOPOLAMINE HYDROBROMIDE prevents motion sickness,3009,Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents motion sickness"" supported by the sentence: ""Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.""?",False, -26997768,Metopimazine affects Nausea,3010,"RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.","Is the triple ""Metopimazine affects Nausea"" supported by the sentence: ""RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.""?",False, -12265728,Metopimazine prevents Nausea,3011,"This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.","Is the triple ""Metopimazine prevents Nausea"" supported by the sentence: ""This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.""?",False, -27200379,Lincomycin related to osteomyelitis,3012,[Optimal regime of intravenous administration of lincomycin in osteomyelitis].,"Is the triple ""Lincomycin related to osteomyelitis"" supported by the sentence: ""[Optimal regime of intravenous administration of lincomycin in osteomyelitis].""?",False, -9905527,Sulindac causes classic familial adenomatous polyposis,3013,"CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.","Is the triple ""Sulindac causes classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.""?",False, -9905522,Sulindac affects classic familial adenomatous polyposis,3014,Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.""?",False, -8547552,Sulindac affects classic familial adenomatous polyposis,3015,CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.""?",False, -11060423,Sulindac prevents classic familial adenomatous polyposis,3016,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Sulindac prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, -20876966,Ketorolac related to migraine disorder,3017,"Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.","Is the triple ""Ketorolac related to migraine disorder"" supported by the sentence: ""Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.""?",False, -27688883,Ketorolac causes Inflammation,3018,We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.,"Is the triple ""Ketorolac causes Inflammation"" supported by the sentence: ""We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.""?",False, -21368479,Ketorolac causes pancreatitis,3019,Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.,"Is the triple ""Ketorolac causes pancreatitis"" supported by the sentence: ""Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.""?",False, -19597016,Ketorolac causes Miosis,3020,CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.,"Is the triple ""Ketorolac causes Miosis"" supported by the sentence: ""CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.""?",False, -12090892,Ketorolac causes Pain,3021,"However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.","Is the triple ""Ketorolac causes Pain"" supported by the sentence: ""However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.""?",False, -20018980,Ketorolac affects breast neoplasm,3022,The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.,"Is the triple ""Ketorolac affects breast neoplasm"" supported by the sentence: ""The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.""?",False, -19245410,Ketorolac affects Miosis,3023,"Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.","Is the triple ""Ketorolac affects Miosis"" supported by the sentence: ""Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.""?",False, -9719257,Ketorolac affects Pain,3024,Effect of pretreatment with ketorolac on propofol injection pain.,"Is the triple ""Ketorolac affects Pain"" supported by the sentence: ""Effect of pretreatment with ketorolac on propofol injection pain.""?",False, -24071071,Ketorolac disrupts Headache,3025,CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.,"Is the triple ""Ketorolac disrupts Headache"" supported by the sentence: ""CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.""?",False, -24029444,Ketorolac disrupts Inflammation,3026,"Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.","Is the triple ""Ketorolac disrupts Inflammation"" supported by the sentence: ""Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.""?",False, -11549492,Ketorolac disrupts Pain,3027,Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.,"Is the triple ""Ketorolac disrupts Pain"" supported by the sentence: ""Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.""?",False, -11362008,Ketorolac disrupts Back pain,3028,"Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.","Is the triple ""Ketorolac disrupts Back pain"" supported by the sentence: ""Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.""?",False, -24306825,Ketorolac prevents Renal Colic,3029,"Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.","Is the triple ""Ketorolac prevents Renal Colic"" supported by the sentence: ""Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.""?",False, -23612322,Ketorolac prevents Chronic pain,3030,"A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.","Is the triple ""Ketorolac prevents Chronic pain"" supported by the sentence: ""A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.""?",False, -20717559,Ketorolac prevents injury,3031,There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.,"Is the triple ""Ketorolac prevents injury"" supported by the sentence: ""There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.""?",False, -11362007,Ketorolac prevents Back pain,3032,Intradermal ketorolac for reduction of epidural back pain.,"Is the triple ""Ketorolac prevents Back pain"" supported by the sentence: ""Intradermal ketorolac for reduction of epidural back pain.""?",False, -11361661,Ketorolac prevents Inflammation,3033,CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.,"Is the triple ""Ketorolac prevents Inflammation"" supported by the sentence: ""CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.""?",False, -11043378,Ketorolac prevents Headache,3034,"At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).","Is the triple ""Ketorolac prevents Headache"" supported by the sentence: ""At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).""?",False, -7985904,Ketorolac prevents Pain,3035,Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.,"Is the triple ""Ketorolac prevents Pain"" supported by the sentence: ""Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.""?",False, -20028754,Ketorolac predisposes injury,3036,"The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.","Is the triple ""Ketorolac predisposes injury"" supported by the sentence: ""The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.""?",False, -25929768,Sulfadiazine related to congenital toxoplasmosis,3037,"[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].","Is the triple ""Sulfadiazine related to congenital toxoplasmosis"" supported by the sentence: ""[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].""?",False, -16546748,Sulfadiazine related to chorioretinitis,3038,"The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.","Is the triple ""Sulfadiazine related to chorioretinitis"" supported by the sentence: ""The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.""?",False, -27660461,Sulfamethoxazole causes pneumonia,3039,"Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.","Is the triple ""Sulfamethoxazole causes pneumonia"" supported by the sentence: ""Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.""?",False, -24328685,Sulfamethoxazole causes kidney disorder,3040,"In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.","Is the triple ""Sulfamethoxazole causes kidney disorder"" supported by the sentence: ""In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.""?",False, -14835537,Sulfamethoxazole affects cystic fibrosis,3041,The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).,"Is the triple ""Sulfamethoxazole affects cystic fibrosis"" supported by the sentence: ""The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).""?",False, -12226918,Sulfamethoxazole affects ocular toxoplasmosis,3042,PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.,"Is the triple ""Sulfamethoxazole affects ocular toxoplasmosis"" supported by the sentence: ""PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.""?",False, -26634163,Sulfamethoxazole prevents bacterial infectious disease,3043,These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.,"Is the triple ""Sulfamethoxazole prevents bacterial infectious disease"" supported by the sentence: ""These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.""?",False, -23781290,Sulfamethoxazole prevents Infection,3044,"Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.","Is the triple ""Sulfamethoxazole prevents Infection"" supported by the sentence: ""Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.""?",False, -22185408,Sulfamethoxazole prevents pneumocystosis,3045,The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.,"Is the triple ""Sulfamethoxazole prevents pneumocystosis"" supported by the sentence: ""The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.""?",False, -21716989,Glycyrrhizic acid affects osteoarthritis,3046,"However, it has not been reported whether glycyrrhizin has a positive effect on OA development.","Is the triple ""Glycyrrhizic acid affects osteoarthritis"" supported by the sentence: ""However, it has not been reported whether glycyrrhizin has a positive effect on OA development.""?",False, -21716987,Glycyrrhizic acid disrupts osteoarthritis,3047,Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.,"Is the triple ""Glycyrrhizic acid disrupts osteoarthritis"" supported by the sentence: ""Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.""?",False, -13246285,Ciclesonide related to perennial allergic rhinitis,3048,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to perennial allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, -13246284,Ciclesonide related to seasonal allergic rhinitis,3049,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to seasonal allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, -10789097,Ciclesonide related to asthma,3050,[Safety and efficacy of inhaled ciclesonide in asthma].,"Is the triple ""Ciclesonide related to asthma"" supported by the sentence: ""[Safety and efficacy of inhaled ciclesonide in asthma].""?",False, -13334776,Ciclesonide causes asthma,3051,Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.,"Is the triple ""Ciclesonide causes asthma"" supported by the sentence: ""Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.""?",False, -13603690,Ciclesonide affects asthma,3052,Ciclesonide improves measures of small airway involvement in asthma.,"Is the triple ""Ciclesonide affects asthma"" supported by the sentence: ""Ciclesonide improves measures of small airway involvement in asthma.""?",False, -26135729,Flunisolide related to perennial allergic rhinitis,3053,Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.,"Is the triple ""Flunisolide related to perennial allergic rhinitis"" supported by the sentence: ""Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.""?",False, -16438918,Flunisolide related to rhinitis,3054,"Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.","Is the triple ""Flunisolide related to rhinitis"" supported by the sentence: ""Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.""?",False, -7778368,Flunisolide related to asthma,3055,"Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.","Is the triple ""Flunisolide related to asthma"" supported by the sentence: ""Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.""?",False, -12189287,Flunisolide prevents Nasal congestion,3056,"The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.","Is the triple ""Flunisolide prevents Nasal congestion"" supported by the sentence: ""The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.""?",False, -27725383,Etoposide related to hepatoblastoma,3057,"Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.","Is the triple ""Etoposide related to hepatoblastoma"" supported by the sentence: ""Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.""?",False, -27360363,Etoposide related to ependymoma,3058,Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.,"Is the triple ""Etoposide related to ependymoma"" supported by the sentence: ""Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.""?",False, -27062931,Etoposide related to supratentorial primitive neuroectodermal tumor,3059,Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.,"Is the triple ""Etoposide related to supratentorial primitive neuroectodermal tumor"" supported by the sentence: ""Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.""?",False, -26965210,Etoposide related to kidney Wilms tumor,3060,"CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.","Is the triple ""Etoposide related to kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.""?",False, -26632944,Etoposide related to HIV infectious disease,3061,Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.,"Is the triple ""Etoposide related to HIV infectious disease"" supported by the sentence: ""Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.""?",False, -22727077,Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma,3062,"Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.","Is the triple ""Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.""?",False, -21142004,Etoposide related to AIDS,3063,"The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.","Is the triple ""Etoposide related to AIDS"" supported by the sentence: ""The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.""?",False, -20988037,Etoposide related to retinoblastoma,3064,"The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.","Is the triple ""Etoposide related to retinoblastoma"" supported by the sentence: ""The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.""?",False, -20394132,Etoposide related to B-cell neoplasm,3065,"Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.","Is the triple ""Etoposide related to B-cell neoplasm"" supported by the sentence: ""Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.""?",False, -19900770,Etoposide related to myelodysplastic syndrome,3066,Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.,"Is the triple ""Etoposide related to myelodysplastic syndrome"" supported by the sentence: ""Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.""?",False, -18768176,Etoposide related to hematopoietic and lymphoid system neoplasm,3067,"Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.","Is the triple ""Etoposide related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.""?",False, -17380085,Etoposide related to Kaposi's sarcoma,3068,"Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.","Is the triple ""Etoposide related to Kaposi's sarcoma"" supported by the sentence: ""Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.""?",False, -17284305,Etoposide related to bone osteosarcoma,3069,We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.,"Is the triple ""Etoposide related to bone osteosarcoma"" supported by the sentence: ""We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.""?",False, -17191209,Etoposide related to hepatocellular carcinoma,3070,The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).,"Is the triple ""Etoposide related to hepatocellular carcinoma"" supported by the sentence: ""The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).""?",False, -17136035,Etoposide related to diffuse large B-cell lymphoma,3071,"Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).","Is the triple ""Etoposide related to diffuse large B-cell lymphoma"" supported by the sentence: ""Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).""?",False, -16406847,Etoposide related to neuroendocrine carcinoma,3072,"However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.","Is the triple ""Etoposide related to neuroendocrine carcinoma"" supported by the sentence: ""However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.""?",False, -16067960,Etoposide related to cutaneous neuroendocrine carcinoma,3073,"In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.","Is the triple ""Etoposide related to cutaneous neuroendocrine carcinoma"" supported by the sentence: ""In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.""?",False, -15501025,Etoposide related to brain cancer,3074,"Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.","Is the triple ""Etoposide related to brain cancer"" supported by the sentence: ""Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.""?",False, -15141728,Etoposide related to testicular cancer,3075,[Continuous infusion of cisplatin plus etoposide in testicular cancer].,"Is the triple ""Etoposide related to testicular cancer"" supported by the sentence: ""[Continuous infusion of cisplatin plus etoposide in testicular cancer].""?",False, -15031494,Etoposide related to lymphoid leukemia,3076,"Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.","Is the triple ""Etoposide related to lymphoid leukemia"" supported by the sentence: ""Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.""?",False, -14511230,Etoposide related to glioblastoma,3077,Preliminary data by cis-platin and etoposide using in primary glioblastoma.,"Is the triple ""Etoposide related to glioblastoma"" supported by the sentence: ""Preliminary data by cis-platin and etoposide using in primary glioblastoma.""?",False, -14453465,Etoposide related to T-cell non-Hodgkin lymphoma,3078,High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).,"Is the triple ""Etoposide related to T-cell non-Hodgkin lymphoma"" supported by the sentence: ""High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).""?",False, -13764189,"Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive",3079,Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.,"Is the triple ""Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.""?",False, -12298091,Etoposide related to breast neoplasm,3080,"Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.","Is the triple ""Etoposide related to breast neoplasm"" supported by the sentence: ""Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.""?",False, -11028194,Etoposide related to acute lymphoblastic leukemia,3081,"Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.","Is the triple ""Etoposide related to acute lymphoblastic leukemia"" supported by the sentence: ""Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.""?",False, -10672040,Etoposide related to Ewing sarcoma,3082,Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.,"Is the triple ""Etoposide related to Ewing sarcoma"" supported by the sentence: ""Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.""?",False, -10503115,Etoposide related to kidney cancer,3083,We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.,"Is the triple ""Etoposide related to kidney cancer"" supported by the sentence: ""We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.""?",False, -10441577,Etoposide related to chronic myelomonocytic leukemia,3084,"Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.","Is the triple ""Etoposide related to chronic myelomonocytic leukemia"" supported by the sentence: ""Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.""?",False, -10410657,Etoposide related to neutropenia,3085,"The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).","Is the triple ""Etoposide related to neutropenia"" supported by the sentence: ""The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).""?",False, -10182075,Etoposide related to non-Hodgkin lymphoma,3086,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Etoposide related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, -10161953,Etoposide related to squamous cell carcinoma,3087,"Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.","Is the triple ""Etoposide related to squamous cell carcinoma"" supported by the sentence: ""Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.""?",False, -9231982,Etoposide related to carcinoma,3088,"In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].","Is the triple ""Etoposide related to carcinoma"" supported by the sentence: ""In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].""?",False, -9157972,Etoposide related to thymoma,3089,"High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.","Is the triple ""Etoposide related to thymoma"" supported by the sentence: ""High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.""?",False, -9138703,Etoposide related to ovarian cancer,3090,A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.,"Is the triple ""Etoposide related to ovarian cancer"" supported by the sentence: ""A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.""?",False, -9115115,Etoposide related to sarcoma,3091,"The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.","Is the triple ""Etoposide related to sarcoma"" supported by the sentence: ""The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.""?",False, -9024985,Etoposide related to leukemia,3092,The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.,"Is the triple ""Etoposide related to leukemia"" supported by the sentence: ""The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.""?",False, -9008448,Etoposide related to Hodgkins lymphoma,3093,"Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.","Is the triple ""Etoposide related to Hodgkins lymphoma"" supported by the sentence: ""Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.""?",False, -9006645,Etoposide related to neuroblastoma,3094,Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.,"Is the triple ""Etoposide related to neuroblastoma"" supported by the sentence: ""Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.""?",False, -8074798,Etoposide related to medulloblastoma,3095,"When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.","Is the triple ""Etoposide related to medulloblastoma"" supported by the sentence: ""When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.""?",False, -8048523,Etoposide related to lymphoma,3096,Oral etoposide in lymphoma.,"Is the triple ""Etoposide related to lymphoma"" supported by the sentence: ""Oral etoposide in lymphoma.""?",False, -7998504,Etoposide related to plasma cell myeloma,3097,"Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.","Is the triple ""Etoposide related to plasma cell myeloma"" supported by the sentence: ""Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.""?",False, -7989979,Etoposide related to neoplasm,3098,"Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.","Is the triple ""Etoposide related to neoplasm"" supported by the sentence: ""Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.""?",False, -7896801,Etoposide related to adult T-cell leukemia/lymphoma,3099,"Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.","Is the triple ""Etoposide related to adult T-cell leukemia/lymphoma"" supported by the sentence: ""Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.""?",False, -7845509,Etoposide related to glioma,3100,Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.,"Is the triple ""Etoposide related to glioma"" supported by the sentence: ""Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.""?",False, -7810052,Etoposide related to castration-resistant prostate carcinoma,3101,"Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.","Is the triple ""Etoposide related to castration-resistant prostate carcinoma"" supported by the sentence: ""Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.""?",False, -7711547,Etoposide related to acute myeloid leukemia,3102,Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.,"Is the triple ""Etoposide related to acute myeloid leukemia"" supported by the sentence: ""Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.""?",False, -7319060,Etoposide related to small cell lung carcinoma,3103,Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.,"Is the triple ""Etoposide related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.""?",False, -7200681,Etoposide related to non-small cell lung carcinoma,3104,Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.,"Is the triple ""Etoposide related to non-small cell lung carcinoma"" supported by the sentence: ""Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.""?",False, -23328204,Etoposide causes small cell lung carcinoma,3105,This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.,"Is the triple ""Etoposide causes small cell lung carcinoma"" supported by the sentence: ""This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.""?",False, -12215704,Etoposide causes neoplasm,3106,"In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.","Is the triple ""Etoposide causes neoplasm"" supported by the sentence: ""In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.""?",False, -8706370,Etoposide causes neutropenia,3107,"The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.","Is the triple ""Etoposide causes neutropenia"" supported by the sentence: ""The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.""?",False, -7869845,Etoposide causes leukemia,3108,"There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.","Is the triple ""Etoposide causes leukemia"" supported by the sentence: ""There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.""?",False, -7642766,Etoposide causes acute myeloid leukemia,3109,Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.,"Is the triple ""Etoposide causes acute myeloid leukemia"" supported by the sentence: ""Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.""?",False, -27374335,Etoposide affects retinoblastoma,3110,"METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.","Is the triple ""Etoposide affects retinoblastoma"" supported by the sentence: ""METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.""?",False, -26960810,Etoposide affects small cell lung carcinoma,3111,"BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.","Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.""?",False, -25269562,Etoposide affects hemophagocytic syndrome,3112,"She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.","Is the triple ""Etoposide affects hemophagocytic syndrome"" supported by the sentence: ""She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.""?",False, -23238600,Etoposide affects choriocarcinoma,3113,[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].,"Is the triple ""Etoposide affects choriocarcinoma"" supported by the sentence: ""[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].""?",False, -18166706,Etoposide affects neuroblastoma,3114,Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.,"Is the triple ""Etoposide affects neuroblastoma"" supported by the sentence: ""Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.""?",False, -17967080,Etoposide affects leukemia,3115,"Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.""?",False, -17160632,Etoposide affects carcinoma,3116,The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.,"Is the triple ""Etoposide affects carcinoma"" supported by the sentence: ""The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.""?",False, -16724406,Etoposide affects neoplasm,3117,The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.,"Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.""?",False, -16425822,Etoposide affects leukemia,3118,"Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.""?",False, -15965763,Etoposide affects testicular cancer,3119,"Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).","Is the triple ""Etoposide affects testicular cancer"" supported by the sentence: ""Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).""?",False, -12798395,Etoposide affects hematopoietic and lymphoid system neoplasm,3120,Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.,"Is the triple ""Etoposide affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.""?",False, -11699750,Etoposide affects small cell lung carcinoma,3121,CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.,"Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.""?",False, -11396769,Etoposide affects chronic myelomonocytic leukemia,3122,"He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.","Is the triple ""Etoposide affects chronic myelomonocytic leukemia"" supported by the sentence: ""He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.""?",False, -9913818,Etoposide affects acute erythroid leukemia,3123,"Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.","Is the triple ""Etoposide affects acute erythroid leukemia"" supported by the sentence: ""Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.""?",False, -9397866,Etoposide affects fallopian tube neoplasm,3124,Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.,"Is the triple ""Etoposide affects fallopian tube neoplasm"" supported by the sentence: ""Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.""?",False, -9293530,Etoposide affects carcinoid tumor,3125,Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.,"Is the triple ""Etoposide affects carcinoid tumor"" supported by the sentence: ""Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.""?",False, -8200378,Etoposide affects neoplasm,3126,"Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.","Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.""?",False, -8003315,Etoposide affects cutaneous neuroendocrine carcinoma,3127,"We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.","Is the triple ""Etoposide affects cutaneous neuroendocrine carcinoma"" supported by the sentence: ""We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.""?",False, -7908520,Etoposide affects B-cell neoplasm,3128,CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).,"Is the triple ""Etoposide affects B-cell neoplasm"" supported by the sentence: ""CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).""?",False, -24115005,Etoposide disrupts small cell lung carcinoma,3129,In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.,"Is the triple ""Etoposide disrupts small cell lung carcinoma"" supported by the sentence: ""In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.""?",False, -17149618,Etoposide disrupts hemophagocytic syndrome,3130,Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).,"Is the triple ""Etoposide disrupts hemophagocytic syndrome"" supported by the sentence: ""Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).""?",False, -16511954,Etoposide disrupts glioblastoma,3131,"In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.","Is the triple ""Etoposide disrupts glioblastoma"" supported by the sentence: ""In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.""?",False, -16039903,Etoposide disrupts neoplasm,3132,"While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).","Is the triple ""Etoposide disrupts neoplasm"" supported by the sentence: ""While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).""?",False, -14383828,Etoposide disrupts bone osteosarcoma,3133,CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).,"Is the triple ""Etoposide disrupts bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).""?",False, -9134229,Etoposide prevents neoplasm,3134,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Etoposide prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, -22634859,Etoposide predisposes neoplasm,3135,Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.,"Is the triple ""Etoposide predisposes neoplasm"" supported by the sentence: ""Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.""?",False, -18673787,Etoposide predisposes brain cancer,3136,"Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.","Is the triple ""Etoposide predisposes brain cancer"" supported by the sentence: ""Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.""?",False, -16345738,Etoposide predisposes myelodysplastic syndrome,3137,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes myelodysplastic syndrome"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, -16345737,Etoposide predisposes acute myeloid leukemia,3138,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes acute myeloid leukemia"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, -10333072,Etoposide predisposes leukemia,3139,"Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.","Is the triple ""Etoposide predisposes leukemia"" supported by the sentence: ""Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.""?",False, -16677028,Teniposide related to neoplasm,3140,"Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.","Is the triple ""Teniposide related to neoplasm"" supported by the sentence: ""Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.""?",False, -10688707,Teniposide related to lymphoma,3141,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to lymphoma"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, -10688706,Teniposide related to leukemia,3142,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to leukemia"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, -27095076,Teniposide affects leukemia,3143,"These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.","Is the triple ""Teniposide affects leukemia"" supported by the sentence: ""These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.""?",False, -26849066,Teniposide predisposes leukemia,3144,"CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.","Is the triple ""Teniposide predisposes leukemia"" supported by the sentence: ""CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.""?",False, -18768362,Urofollitropin related to hypogonadism,3145,"RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.","Is the triple ""Urofollitropin related to hypogonadism"" supported by the sentence: ""RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.""?",False, -18095820,Urofollitropin related to primary ovarian failure,3146,"In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.","Is the triple ""Urofollitropin related to primary ovarian failure"" supported by the sentence: ""In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.""?",False, -9960851,Urofollitropin related to anovulation,3147,Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.,"Is the triple ""Urofollitropin related to anovulation"" supported by the sentence: ""Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.""?",False, -9716197,Urofollitropin related to female infertility,3148,OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.,"Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.""?",False, -8496709,Urofollitropin related to infertility disorder,3149,"BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.","Is the triple ""Urofollitropin related to infertility disorder"" supported by the sentence: ""BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.""?",False, -8454088,Urofollitropin related to male infertility,3150,Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.,"Is the triple ""Urofollitropin related to male infertility"" supported by the sentence: ""Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.""?",False, -8378642,Urofollitropin related to polycystic ovary syndrome,3151,"From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.","Is the triple ""Urofollitropin related to polycystic ovary syndrome"" supported by the sentence: ""From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.""?",False, -8205307,Urofollitropin related to azoospermia,3152,"Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.","Is the triple ""Urofollitropin related to azoospermia"" supported by the sentence: ""Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.""?",False, -14878529,Urofollitropin related to female infertility,3153,"OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).","Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).""?",False, -9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3154,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, -9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3155,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, -10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3156,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, -10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3157,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, -7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3158,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, -7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3159,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, -7302412,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3160,The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.,"Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.""?",False, -7606444,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3161,"The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.","Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.""?",False, -21372974,Urofollitropin causes polycystic ovary syndrome,3162,"In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.","Is the triple ""Urofollitropin causes polycystic ovary syndrome"" supported by the sentence: ""In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.""?",False, -16723493,Urofollitropin causes hypogonadism,3163,"FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.","Is the triple ""Urofollitropin causes hypogonadism"" supported by the sentence: ""FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.""?",False, -16322495,Urofollitropin causes azoospermia,3164,Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.,"Is the triple ""Urofollitropin causes azoospermia"" supported by the sentence: ""Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.""?",False, -9453052,Urofollitropin causes primary ovarian failure,3165,"An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.","Is the triple ""Urofollitropin causes primary ovarian failure"" supported by the sentence: ""An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.""?",False, -8923757,Urofollitropin causes Pregnancy,3166,"However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.","Is the triple ""Urofollitropin causes Pregnancy"" supported by the sentence: ""However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.""?",False, -8815215,Urofollitropin causes anovulation,3167,"Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.","Is the triple ""Urofollitropin causes anovulation"" supported by the sentence: ""Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.""?",False, -8590972,Urofollitropin causes male infertility,3168,"Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.","Is the triple ""Urofollitropin causes male infertility"" supported by the sentence: ""Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.""?",False, -8270576,Urofollitropin causes infertility disorder,3169,Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.,"Is the triple ""Urofollitropin causes infertility disorder"" supported by the sentence: ""Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.""?",False, -19357829,Urofollitropin affects gonadal disorder,3170,"Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.","Is the triple ""Urofollitropin affects gonadal disorder"" supported by the sentence: ""Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.""?",False, -15865492,Urofollitropin affects polycystic ovary syndrome,3171,"The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.","Is the triple ""Urofollitropin affects polycystic ovary syndrome"" supported by the sentence: ""The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.""?",False, -14984090,Urofollitropin affects male infertility,3172,The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.""?",False, -13249247,Urofollitropin affects Pregnancy,3173,"CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.","Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.""?",False, -10980447,Urofollitropin affects Pregnancy,3174,BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.,"Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.""?",False, -8590971,Urofollitropin affects male infertility,3175,The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.""?",False, -7302415,Urofollitropin affects Follicle Stimulating Hormone Receptor,3176,These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.""?",False, -9844029,Urofollitropin affects Follicle Stimulating Hormone Receptor,3177,This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.""?",False, -27587327,Urofollitropin produces primary ovarian failure,3178,"Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).","Is the triple ""Urofollitropin produces primary ovarian failure"" supported by the sentence: ""Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).""?",False, -20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3179,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, -20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3180,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, -8502213,Urofollitropin produces polycystic ovary syndrome,3181,"RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.","Is the triple ""Urofollitropin produces polycystic ovary syndrome"" supported by the sentence: ""RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.""?",False, -20569186,Urofollitropin disrupts Pregnancy,3182,"RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.","Is the triple ""Urofollitropin disrupts Pregnancy"" supported by the sentence: ""RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.""?",False, -11195885,Urofollitropin prevents azoospermia,3183,"While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.","Is the triple ""Urofollitropin prevents azoospermia"" supported by the sentence: ""While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.""?",False, -17502146,Urofollitropin predisposes azoospermia,3184,"On multivariate analysis, only FSH remained predictive of NOA.","Is the triple ""Urofollitropin predisposes azoospermia"" supported by the sentence: ""On multivariate analysis, only FSH remained predictive of NOA.""?",False, -16417247,Urofollitropin predisposes anovulation,3185,"CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.","Is the triple ""Urofollitropin predisposes anovulation"" supported by the sentence: ""CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.""?",False, -16278695,Urofollitropin predisposes infertility disorder,3186,"The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).","Is the triple ""Urofollitropin predisposes infertility disorder"" supported by the sentence: ""The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).""?",False, -15110465,Urofollitropin predisposes polycystic ovary syndrome,3187,"LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).","Is the triple ""Urofollitropin predisposes polycystic ovary syndrome"" supported by the sentence: ""LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).""?",False, -7379891,Urofollitropin predisposes primary ovarian failure,3188,Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.,"Is the triple ""Urofollitropin predisposes primary ovarian failure"" supported by the sentence: ""Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.""?",False, -23895216,Ivacaftor affects cystic fibrosis,3189,Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.,"Is the triple ""Ivacaftor affects cystic fibrosis"" supported by the sentence: ""Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.""?",False, -20354463,Nitric oxide related to ST-elevation myocardial infarction,3190,The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.,"Is the triple ""Nitric oxide related to ST-elevation myocardial infarction"" supported by the sentence: ""The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.""?",False, -17273075,Nitric oxide related to bronchiolitis,3191,"By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.","Is the triple ""Nitric oxide related to bronchiolitis"" supported by the sentence: ""By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.""?",False, -15880296,Nitric oxide related to Diabetic Foot,3192,"Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).","Is the triple ""Nitric oxide related to Diabetic Foot"" supported by the sentence: ""Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).""?",False, -14910010,Nitric oxide related to severe acute respiratory syndrome,3193,Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.,"Is the triple ""Nitric oxide related to severe acute respiratory syndrome"" supported by the sentence: ""Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.""?",False, -14573099,Nitric oxide related to bronchopulmonary dysplasia,3194,"The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.","Is the triple ""Nitric oxide related to bronchopulmonary dysplasia"" supported by the sentence: ""The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.""?",False, -11752178,Nitric oxide related to cutaneous leishmaniasis,3195,"Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.","Is the triple ""Nitric oxide related to cutaneous leishmaniasis"" supported by the sentence: ""Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.""?",False, -9816415,Nitric oxide related to newborn respiratory distress syndrome,3196,"To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.","Is the triple ""Nitric oxide related to newborn respiratory distress syndrome"" supported by the sentence: ""To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.""?",False, -9774015,Nitric oxide related to respiratory system disorder,3197,Nitric oxide in respiratory diseases.,"Is the triple ""Nitric oxide related to respiratory system disorder"" supported by the sentence: ""Nitric oxide in respiratory diseases.""?",False, -8707490,Nitric oxide related to myocardial infarction,3198,"Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.","Is the triple ""Nitric oxide related to myocardial infarction"" supported by the sentence: ""Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.""?",False, -8593326,Nitric oxide related to neuralgia,3199,This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.,"Is the triple ""Nitric oxide related to neuralgia"" supported by the sentence: ""This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.""?",False, -8476870,Nitric oxide related to lung disorder,3200,"Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.","Is the triple ""Nitric oxide related to lung disorder"" supported by the sentence: ""Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.""?",False, -8350800,Nitric oxide related to opiate dependence,3201,"RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.","Is the triple ""Nitric oxide related to opiate dependence"" supported by the sentence: ""RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.""?",False, -8343542,Nitric oxide related to Varicose Ulcer,3202,"NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.","Is the triple ""Nitric oxide related to Varicose Ulcer"" supported by the sentence: ""NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.""?",False, -8057943,Nitric oxide related to malaria,3203,Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.,"Is the triple ""Nitric oxide related to malaria"" supported by the sentence: ""Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.""?",False, -8040944,Nitric oxide related to sickle cell anemia,3204,Strategies that enhance NO activity may be therapeutic in sickle cell disease.,"Is the triple ""Nitric oxide related to sickle cell anemia"" supported by the sentence: ""Strategies that enhance NO activity may be therapeutic in sickle cell disease.""?",False, -7963930,Nitric oxide related to cystic fibrosis,3205,"As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.","Is the triple ""Nitric oxide related to cystic fibrosis"" supported by the sentence: ""As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.""?",False, -7923041,Nitric oxide related to brain injury,3206,"While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.","Is the triple ""Nitric oxide related to brain injury"" supported by the sentence: ""While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.""?",False, -7788094,Nitric oxide related to myocardial ischemia,3207,"This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.","Is the triple ""Nitric oxide related to myocardial ischemia"" supported by the sentence: ""This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.""?",False, -7738003,Nitric oxide related to Hypoxemia,3208,"In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.","Is the triple ""Nitric oxide related to Hypoxemia"" supported by the sentence: ""In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.""?",False, -7725812,Nitric oxide related to Premature birth,3209,"Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.","Is the triple ""Nitric oxide related to Premature birth"" supported by the sentence: ""Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.""?",False, -7657450,Nitric oxide related to pulmonary embolism,3210,Use of inhaled nitric oxide in pulmonary embolism.,"Is the triple ""Nitric oxide related to pulmonary embolism"" supported by the sentence: ""Use of inhaled nitric oxide in pulmonary embolism.""?",False, -7539810,Nitric oxide related to stroke disorder,3211,The findings indicate the importance of nitric oxide in stroke and ischemia.,"Is the triple ""Nitric oxide related to stroke disorder"" supported by the sentence: ""The findings indicate the importance of nitric oxide in stroke and ischemia.""?",False, -7481315,Nitric oxide related to chronic obstructive pulmonary disease,3212,Exhaled nitric oxide in COPD: glancing through a smoke screen.,"Is the triple ""Nitric oxide related to chronic obstructive pulmonary disease"" supported by the sentence: ""Exhaled nitric oxide in COPD: glancing through a smoke screen.""?",False, -7449413,Nitric oxide related to respiratory failure,3213,Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.,"Is the triple ""Nitric oxide related to respiratory failure"" supported by the sentence: ""Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.""?",False, -7439172,Nitric oxide related to neoplasm,3214,"Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.","Is the triple ""Nitric oxide related to neoplasm"" supported by the sentence: ""Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.""?",False, -7418030,Nitric oxide related to acute kidney failure,3215,BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.,"Is the triple ""Nitric oxide related to acute kidney failure"" supported by the sentence: ""BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.""?",False, -7373096,Nitric oxide related to brain ischemia,3216,"Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.","Is the triple ""Nitric oxide related to brain ischemia"" supported by the sentence: ""Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.""?",False, -7345317,Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins,3217,"CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.","Is the triple ""Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.""?",False, -7242606,Nitric oxide related to adult acute respiratory distress syndrome,3218,Inhaled nitric oxide may also have therapeutic potential in ARDS.,"Is the triple ""Nitric oxide related to adult acute respiratory distress syndrome"" supported by the sentence: ""Inhaled nitric oxide may also have therapeutic potential in ARDS.""?",False, -7159413,Nitric oxide related to Sepsis,3219,"CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.","Is the triple ""Nitric oxide related to Sepsis"" supported by the sentence: ""CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.""?",False, -7145311,Nitric oxide related to Inflammation,3220,Nitric oxide protects in intestinal inflammation.,"Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Nitric oxide protects in intestinal inflammation.""?",False, -7091337,Nitric oxide related to ischemia reperfusion injury,3221,This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.,"Is the triple ""Nitric oxide related to ischemia reperfusion injury"" supported by the sentence: ""This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.""?",False, -14184908,Nitric oxide related to Inflammation,3222,"Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.","Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.""?",False, -27698007,Nitric oxide causes lung disorder,3223,"Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.","Is the triple ""Nitric oxide causes lung disorder"" supported by the sentence: ""Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.""?",False, -23636922,Nitric oxide causes Infection,3224,"Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.","Is the triple ""Nitric oxide causes Infection"" supported by the sentence: ""Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.""?",False, -22013082,Nitric oxide causes sickle cell anemia,3225,"Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.","Is the triple ""Nitric oxide causes sickle cell anemia"" supported by the sentence: ""Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.""?",False, -21447838,Nitric oxide causes respiratory system disorder,3226,NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.,"Is the triple ""Nitric oxide causes respiratory system disorder"" supported by the sentence: ""NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.""?",False, -14028136,Nitric oxide causes stroke disorder,3227,"OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.","Is the triple ""Nitric oxide causes stroke disorder"" supported by the sentence: ""OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.""?",False, -12046903,Nitric oxide causes cystic fibrosis,3228,CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.,"Is the triple ""Nitric oxide causes cystic fibrosis"" supported by the sentence: ""CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.""?",False, -11887505,Nitric oxide causes myocardial ischemia,3229,"RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.","Is the triple ""Nitric oxide causes myocardial ischemia"" supported by the sentence: ""RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.""?",False, -11842330,Nitric oxide causes ischemia reperfusion injury,3230,BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).,"Is the triple ""Nitric oxide causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).""?",False, -11556568,Nitric oxide causes acute kidney failure,3231,NO plays a dual role of protection and damage in the pathogenesis of ARF.,"Is the triple ""Nitric oxide causes acute kidney failure"" supported by the sentence: ""NO plays a dual role of protection and damage in the pathogenesis of ARF.""?",False, -11353052,Nitric oxide causes adult acute respiratory distress syndrome,3232,"CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.","Is the triple ""Nitric oxide causes adult acute respiratory distress syndrome"" supported by the sentence: ""CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.""?",False, -9962165,Nitric oxide causes malaria,3233,We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.,"Is the triple ""Nitric oxide causes malaria"" supported by the sentence: ""We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.""?",False, -9795722,Nitric oxide causes neuralgia,3234,OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.,"Is the triple ""Nitric oxide causes neuralgia"" supported by the sentence: ""OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.""?",False, -9068211,Nitric oxide causes pneumonia,3235,"A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.","Is the triple ""Nitric oxide causes pneumonia"" supported by the sentence: ""A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.""?",False, -8934561,Nitric oxide causes brain injury,3236,"It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.","Is the triple ""Nitric oxide causes brain injury"" supported by the sentence: ""It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.""?",False, -8855613,Nitric oxide causes neoplasm,3237,Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.,"Is the triple ""Nitric oxide causes neoplasm"" supported by the sentence: ""Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.""?",False, -8834736,Nitric oxide causes myocardial infarction,3238,"Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.","Is the triple ""Nitric oxide causes myocardial infarction"" supported by the sentence: ""Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.""?",False, -8346309,Nitric oxide causes Premature birth,3239,The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.,"Is the triple ""Nitric oxide causes Premature birth"" supported by the sentence: ""The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.""?",False, -8185371,Nitric oxide causes Inflammation,3240,Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.,"Is the triple ""Nitric oxide causes Inflammation"" supported by the sentence: ""Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.""?",False, -8037779,Nitric oxide causes brain ischemia,3241,"Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.","Is the triple ""Nitric oxide causes brain ischemia"" supported by the sentence: ""Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.""?",False, -7409857,Nitric oxide causes Sepsis,3242,Nitric oxide in the pathogenesis of sepsis.,"Is the triple ""Nitric oxide causes Sepsis"" supported by the sentence: ""Nitric oxide in the pathogenesis of sepsis.""?",False, -7184490,Nitric oxide causes Hypoxemia,3243,These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.,"Is the triple ""Nitric oxide causes Hypoxemia"" supported by the sentence: ""These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.""?",False, -27626134,Nitric oxide affects cystic fibrosis,3244,"We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.","Is the triple ""Nitric oxide affects cystic fibrosis"" supported by the sentence: ""We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.""?",False, -27208311,Nitric oxide affects opiate dependence,3245,"NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.","Is the triple ""Nitric oxide affects opiate dependence"" supported by the sentence: ""NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.""?",False, -27058878,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3246,The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.,"Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.""?",False, -20413999,Nitric oxide affects brain injury,3247,"Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.","Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.""?",False, -19764415,Nitric oxide affects pneumonia,3248,"Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.""?",False, -18632674,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3249,"We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.","Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.""?",False, -17798838,Nitric oxide affects neuralgia,3250,"All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.","Is the triple ""Nitric oxide affects neuralgia"" supported by the sentence: ""All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.""?",False, -17030125,Nitric oxide affects bronchiolitis,3251,Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.,"Is the triple ""Nitric oxide affects bronchiolitis"" supported by the sentence: ""Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.""?",False, -12566083,Nitric oxide affects respiratory system disorder,3252,Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.,"Is the triple ""Nitric oxide affects respiratory system disorder"" supported by the sentence: ""Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.""?",False, -11778681,Nitric oxide affects stroke disorder,3253,Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.,"Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.""?",False, -11521495,Nitric oxide affects severe acute respiratory syndrome,3254,"These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.","Is the triple ""Nitric oxide affects severe acute respiratory syndrome"" supported by the sentence: ""These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.""?",False, -11353389,Nitric oxide affects myocardial infarction,3255,Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.,"Is the triple ""Nitric oxide affects myocardial infarction"" supported by the sentence: ""Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.""?",False, -10403969,Nitric oxide affects anemia,3256,"Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.""?",False, -10222313,Nitric oxide affects ischemia reperfusion injury,3257,CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.,"Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.""?",False, -10099288,Nitric oxide affects myocardial ischemia,3258,Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.""?",False, -10018002,Nitric oxide affects acute kidney failure,3259,"Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.","Is the triple ""Nitric oxide affects acute kidney failure"" supported by the sentence: ""Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.""?",False, -10008267,Nitric oxide affects lung disorder,3260,"Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.","Is the triple ""Nitric oxide affects lung disorder"" supported by the sentence: ""Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.""?",False, -9982988,Nitric oxide affects respiratory failure,3261,Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.,"Is the triple ""Nitric oxide affects respiratory failure"" supported by the sentence: ""Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.""?",False, -9910920,Nitric oxide affects brain ischemia,3262,These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.,"Is the triple ""Nitric oxide affects brain ischemia"" supported by the sentence: ""These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.""?",False, -9742582,Nitric oxide affects stroke disorder,3263,"The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.","Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.""?",False, -9649727,Nitric oxide affects neoplasm,3264,Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.""?",False, -9102608,Nitric oxide affects Hypoxemia,3265,Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.,"Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.""?",False, -9095187,Nitric oxide affects newborn respiratory distress syndrome,3266,"There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.","Is the triple ""Nitric oxide affects newborn respiratory distress syndrome"" supported by the sentence: ""There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.""?",False, -8891949,Nitric oxide affects Sepsis,3267,"Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.""?",False, -8832872,Nitric oxide affects pneumonia,3268,"The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.""?",False, -8646255,Nitric oxide affects myocardial ischemia,3269,The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.""?",False, -8473168,Nitric oxide affects neoplasm,3270,NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.""?",False, -8202584,Nitric oxide affects Sepsis,3271,"Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.""?",False, -8139693,Nitric oxide affects brain injury,3272,Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.,"Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.""?",False, -7935763,Nitric oxide affects chronic obstructive pulmonary disease,3273,The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.""?",False, -7896362,Nitric oxide affects Inflammation,3274,"Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.","Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.""?",False, -7780898,Nitric oxide affects chronic obstructive pulmonary disease,3275,Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.""?",False, -7712088,Nitric oxide affects Hypoxemia,3276,"By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.","Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.""?",False, -7542916,Nitric oxide affects anemia,3277,"Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).""?",False, -7169788,Nitric oxide affects Inflammation,3278,Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.,"Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.""?",False, -7164340,Nitric oxide affects ischemia reperfusion injury,3279,"The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.","Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.""?",False, -7094195,Nitric oxide affects malaria,3280,Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.,"Is the triple ""Nitric oxide affects malaria"" supported by the sentence: ""Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.""?",False, -20359925,Nitric oxide produces chronic obstructive pulmonary disease,3281,"However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.","Is the triple ""Nitric oxide produces chronic obstructive pulmonary disease"" supported by the sentence: ""However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.""?",False, -20299429,Nitric oxide produces pneumonia,3282,We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.,"Is the triple ""Nitric oxide produces pneumonia"" supported by the sentence: ""We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.""?",False, -17925357,Nitric oxide produces bronchopulmonary dysplasia,3283,"The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.","Is the triple ""Nitric oxide produces bronchopulmonary dysplasia"" supported by the sentence: ""The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.""?",False, -15219259,Nitric oxide produces Premature birth,3284,CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.,"Is the triple ""Nitric oxide produces Premature birth"" supported by the sentence: ""CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.""?",False, -13106727,Nitric oxide produces adult acute respiratory distress syndrome,3285,"Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.","Is the triple ""Nitric oxide produces adult acute respiratory distress syndrome"" supported by the sentence: ""Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.""?",False, -12774415,Nitric oxide produces stroke disorder,3286,The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.,"Is the triple ""Nitric oxide produces stroke disorder"" supported by the sentence: ""The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.""?",False, -12205025,Nitric oxide produces Varicose Ulcer,3287,"The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.","Is the triple ""Nitric oxide produces Varicose Ulcer"" supported by the sentence: ""The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.""?",False, -11786457,Nitric oxide produces brain ischemia,3288,"One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.","Is the triple ""Nitric oxide produces brain ischemia"" supported by the sentence: ""One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.""?",False, -9816411,Nitric oxide produces newborn respiratory distress syndrome,3289,Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.,"Is the triple ""Nitric oxide produces newborn respiratory distress syndrome"" supported by the sentence: ""Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.""?",False, -8745644,Nitric oxide produces sickle cell anemia,3290,We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.,"Is the triple ""Nitric oxide produces sickle cell anemia"" supported by the sentence: ""We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.""?",False, -8339020,Nitric oxide produces acute kidney failure,3291,"In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.","Is the triple ""Nitric oxide produces acute kidney failure"" supported by the sentence: ""In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.""?",False, -7963932,Nitric oxide produces cystic fibrosis,3292,The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.,"Is the triple ""Nitric oxide produces cystic fibrosis"" supported by the sentence: ""The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.""?",False, -7644756,Nitric oxide produces anemia,3293,"Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.","Is the triple ""Nitric oxide produces anemia"" supported by the sentence: ""Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.""?",False, -7555266,Nitric oxide produces myocardial ischemia,3294,Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.,"Is the triple ""Nitric oxide produces myocardial ischemia"" supported by the sentence: ""Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.""?",False, -7511323,Nitric oxide produces myocardial infarction,3295,"The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).","Is the triple ""Nitric oxide produces myocardial infarction"" supported by the sentence: ""The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).""?",False, -7507297,Nitric oxide produces Inflammation,3296,Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.,"Is the triple ""Nitric oxide produces Inflammation"" supported by the sentence: ""Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.""?",False, -7461061,Nitric oxide produces Hypoxemia,3297,"Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.","Is the triple ""Nitric oxide produces Hypoxemia"" supported by the sentence: ""Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.""?",False, -7435212,Nitric oxide produces neoplasm,3298,"Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.","Is the triple ""Nitric oxide produces neoplasm"" supported by the sentence: ""Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.""?",False, -7390889,Nitric oxide produces Sepsis,3299,"In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.","Is the triple ""Nitric oxide produces Sepsis"" supported by the sentence: ""In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.""?",False, -7094197,Nitric oxide produces malaria,3300,"However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.","Is the triple ""Nitric oxide produces malaria"" supported by the sentence: ""However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.""?",False, -26705109,Nitric oxide disrupts anemia,3301,"NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.","Is the triple ""Nitric oxide disrupts anemia"" supported by the sentence: ""NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.""?",False, -19923810,Nitric oxide disrupts stroke disorder,3302,"CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.","Is the triple ""Nitric oxide disrupts stroke disorder"" supported by the sentence: ""CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.""?",False, -14786185,Nitric oxide disrupts Sepsis,3303,Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.,"Is the triple ""Nitric oxide disrupts Sepsis"" supported by the sentence: ""Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.""?",False, -12247489,Nitric oxide disrupts sickle cell anemia,3304,"Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.","Is the triple ""Nitric oxide disrupts sickle cell anemia"" supported by the sentence: ""Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.""?",False, -11088644,Nitric oxide disrupts cystic fibrosis,3305,"Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.","Is the triple ""Nitric oxide disrupts cystic fibrosis"" supported by the sentence: ""Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.""?",False, -10963665,Nitric oxide disrupts neoplasm,3306,"Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.","Is the triple ""Nitric oxide disrupts neoplasm"" supported by the sentence: ""Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.""?",False, -10158293,Nitric oxide disrupts myocardial ischemia,3307,"Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.","Is the triple ""Nitric oxide disrupts myocardial ischemia"" supported by the sentence: ""Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.""?",False, -9091818,Nitric oxide disrupts respiratory failure,3308,"However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.","Is the triple ""Nitric oxide disrupts respiratory failure"" supported by the sentence: ""However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.""?",False, -8577648,Nitric oxide disrupts Inflammation,3309,In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.,"Is the triple ""Nitric oxide disrupts Inflammation"" supported by the sentence: ""In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.""?",False, -7822328,Nitric oxide disrupts adult acute respiratory distress syndrome,3310,BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).,"Is the triple ""Nitric oxide disrupts adult acute respiratory distress syndrome"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).""?",False, -7750750,Nitric oxide disrupts myocardial infarction,3311,"Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.","Is the triple ""Nitric oxide disrupts myocardial infarction"" supported by the sentence: ""Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.""?",False, -7555296,Nitric oxide disrupts ischemia reperfusion injury,3312,NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.,"Is the triple ""Nitric oxide disrupts ischemia reperfusion injury"" supported by the sentence: ""NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.""?",False, -7358959,Nitric oxide disrupts Hypoxemia,3313,CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.,"Is the triple ""Nitric oxide disrupts Hypoxemia"" supported by the sentence: ""CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.""?",False, -26913950,Nitric oxide prevents adult acute respiratory distress syndrome,3314,"Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.","Is the triple ""Nitric oxide prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.""?",False, -25277893,Nitric oxide prevents neuralgia,3315,"Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.","Is the triple ""Nitric oxide prevents neuralgia"" supported by the sentence: ""Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.""?",False, -22898445,Nitric oxide prevents Infection,3316,The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.,"Is the triple ""Nitric oxide prevents Infection"" supported by the sentence: ""The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.""?",False, -21669107,Nitric oxide prevents neoplasm,3317,"CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.","Is the triple ""Nitric oxide prevents neoplasm"" supported by the sentence: ""CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.""?",False, -21628822,Nitric oxide prevents Hypoxemia,3318,"The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.","Is the triple ""Nitric oxide prevents Hypoxemia"" supported by the sentence: ""The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.""?",False, -21494876,Nitric oxide prevents Inflammation,3319,"This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.","Is the triple ""Nitric oxide prevents Inflammation"" supported by the sentence: ""This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.""?",False, -21062009,Nitric oxide prevents pulmonary embolism,3320,"Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.","Is the triple ""Nitric oxide prevents pulmonary embolism"" supported by the sentence: ""Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.""?",False, -16675253,Nitric oxide prevents stroke disorder,3321,"Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.","Is the triple ""Nitric oxide prevents stroke disorder"" supported by the sentence: ""Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.""?",False, -13634130,Nitric oxide prevents sickle cell anemia,3322,"Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).","Is the triple ""Nitric oxide prevents sickle cell anemia"" supported by the sentence: ""Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).""?",False, -11584828,Nitric oxide prevents brain ischemia,3323,"CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.","Is the triple ""Nitric oxide prevents brain ischemia"" supported by the sentence: ""CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.""?",False, -11450951,Nitric oxide prevents myocardial infarction,3324,BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.,"Is the triple ""Nitric oxide prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.""?",False, -10887585,Nitric oxide prevents pneumonia,3325,"BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.","Is the triple ""Nitric oxide prevents pneumonia"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.""?",False, -9990816,Nitric oxide prevents acute kidney failure,3326,"Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.","Is the triple ""Nitric oxide prevents acute kidney failure"" supported by the sentence: ""Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.""?",False, -9464831,Nitric oxide prevents myocardial ischemia,3327,We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.,"Is the triple ""Nitric oxide prevents myocardial ischemia"" supported by the sentence: ""We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.""?",False, -8988568,Nitric oxide prevents chronic obstructive pulmonary disease,3328,Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).,"Is the triple ""Nitric oxide prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).""?",False, -8396830,Nitric oxide prevents cystic fibrosis,3329,"Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.","Is the triple ""Nitric oxide prevents cystic fibrosis"" supported by the sentence: ""Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.""?",False, -8224065,Nitric oxide prevents brain injury,3330,NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.,"Is the triple ""Nitric oxide prevents brain injury"" supported by the sentence: ""NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.""?",False, -8045867,Nitric oxide prevents lung disorder,3331,These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.,"Is the triple ""Nitric oxide prevents lung disorder"" supported by the sentence: ""These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.""?",False, -7996843,Nitric oxide prevents Sepsis,3332,"One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.","Is the triple ""Nitric oxide prevents Sepsis"" supported by the sentence: ""One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.""?",False, -7713281,Nitric oxide prevents respiratory failure,3333,Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.,"Is the triple ""Nitric oxide prevents respiratory failure"" supported by the sentence: ""Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.""?",False, -7103253,Nitric oxide prevents ischemia reperfusion injury,3334,It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.,"Is the triple ""Nitric oxide prevents ischemia reperfusion injury"" supported by the sentence: ""It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.""?",False, -27558971,Nitric oxide exacerbates myocardial ischemia,3335,Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.,"Is the triple ""Nitric oxide exacerbates myocardial ischemia"" supported by the sentence: ""Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.""?",False, -26883794,Nitric oxide exacerbates acute kidney failure,3336,Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.,"Is the triple ""Nitric oxide exacerbates acute kidney failure"" supported by the sentence: ""Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.""?",False, -24530593,Nitric oxide exacerbates ischemia reperfusion injury,3337,"NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.","Is the triple ""Nitric oxide exacerbates ischemia reperfusion injury"" supported by the sentence: ""NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.""?",False, -23305196,Nitric oxide predisposes cystic fibrosis,3338,"It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.","Is the triple ""Nitric oxide predisposes cystic fibrosis"" supported by the sentence: ""It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.""?",False, -18515843,Nitric oxide predisposes malaria,3339,"We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.","Is the triple ""Nitric oxide predisposes malaria"" supported by the sentence: ""We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.""?",False, -17339126,Nitric oxide predisposes stroke disorder,3340,"OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.","Is the triple ""Nitric oxide predisposes stroke disorder"" supported by the sentence: ""OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.""?",False, -17303048,Nitric oxide predisposes brain ischemia,3341,"To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.","Is the triple ""Nitric oxide predisposes brain ischemia"" supported by the sentence: ""To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.""?",False, -16438716,Nitric oxide predisposes respiratory system disorder,3342,Nitric oxide (NO) is now considered an important biomarker for respiratory disease.,"Is the triple ""Nitric oxide predisposes respiratory system disorder"" supported by the sentence: ""Nitric oxide (NO) is now considered an important biomarker for respiratory disease.""?",False, -16061041,Nitric oxide predisposes lung disorder,3343,"As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.","Is the triple ""Nitric oxide predisposes lung disorder"" supported by the sentence: ""As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.""?",False, -15696584,Nitric oxide predisposes chronic obstructive pulmonary disease,3344,"Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.","Is the triple ""Nitric oxide predisposes chronic obstructive pulmonary disease"" supported by the sentence: ""Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.""?",False, -13236015,Nitric oxide predisposes bronchopulmonary dysplasia,3345,Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.,"Is the triple ""Nitric oxide predisposes bronchopulmonary dysplasia"" supported by the sentence: ""Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.""?",False, -12163328,Nitric oxide predisposes acute kidney failure,3346,"However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).","Is the triple ""Nitric oxide predisposes acute kidney failure"" supported by the sentence: ""However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).""?",False, -12068938,Nitric oxide predisposes neuralgia,3347,"During such processes, NO contributes to the development of neuropathic pain.","Is the triple ""Nitric oxide predisposes neuralgia"" supported by the sentence: ""During such processes, NO contributes to the development of neuropathic pain.""?",False, -11569688,Nitric oxide predisposes Premature birth,3348,CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.,"Is the triple ""Nitric oxide predisposes Premature birth"" supported by the sentence: ""CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.""?",False, -9326529,Nitric oxide predisposes brain injury,3349,"Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.","Is the triple ""Nitric oxide predisposes brain injury"" supported by the sentence: ""Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.""?",False, -8098085,Nitric oxide predisposes neoplasm,3350,These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.,"Is the triple ""Nitric oxide predisposes neoplasm"" supported by the sentence: ""These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.""?",False, -7895713,Nitric oxide predisposes pneumonia,3351,"METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).","Is the triple ""Nitric oxide predisposes pneumonia"" supported by the sentence: ""METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).""?",False, -7863118,Nitric oxide predisposes Hypoxemia,3352,"CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.","Is the triple ""Nitric oxide predisposes Hypoxemia"" supported by the sentence: ""CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.""?",False, -7644760,Nitric oxide predisposes anemia,3353,"After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.","Is the triple ""Nitric oxide predisposes anemia"" supported by the sentence: ""After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.""?",False, -7373094,Nitric oxide predisposes ischemia reperfusion injury,3354,Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.,"Is the triple ""Nitric oxide predisposes ischemia reperfusion injury"" supported by the sentence: ""Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.""?",False, -7119398,Nitric oxide predisposes Inflammation,3355,Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.,"Is the triple ""Nitric oxide predisposes Inflammation"" supported by the sentence: ""Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.""?",False, -18948956,CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome,3356,"OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).","Is the triple ""CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome"" supported by the sentence: ""OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).""?",False, -10437081,CHORIONIC GONADOTROPIN related to hypogonadism,3357,[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].,"Is the triple ""CHORIONIC GONADOTROPIN related to hypogonadism"" supported by the sentence: ""[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].""?",False, -10427260,CHORIONIC GONADOTROPIN related to infertility disorder,3358,[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].,"Is the triple ""CHORIONIC GONADOTROPIN related to infertility disorder"" supported by the sentence: ""[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].""?",False, -25953720,CHORIONIC GONADOTROPIN causes infertility disorder,3359,[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].,"Is the triple ""CHORIONIC GONADOTROPIN causes infertility disorder"" supported by the sentence: ""[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].""?",False, -12680602,CHORIONIC GONADOTROPIN causes Pregnancy,3360,Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.,"Is the triple ""CHORIONIC GONADOTROPIN causes Pregnancy"" supported by the sentence: ""Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.""?",False, -19382665,CHORIONIC GONADOTROPIN affects Pregnancy,3361,"Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.","Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.""?",False, -10661395,CHORIONIC GONADOTROPIN affects Pregnancy,3362,Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.,"Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.""?",False, -11878666,CHORIONIC GONADOTROPIN produces Pregnancy,3363,Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.,"Is the triple ""CHORIONIC GONADOTROPIN produces Pregnancy"" supported by the sentence: ""Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.""?",False, -19257969,Triclosan causes allergic disease,3364,Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.,"Is the triple ""Triclosan causes allergic disease"" supported by the sentence: ""Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.""?",False, -17886883,Triclosan affects gingivitis,3365,A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.,"Is the triple ""Triclosan affects gingivitis"" supported by the sentence: ""A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.""?",False, -9651026,Triclosan disrupts gingivitis,3366,"It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.","Is the triple ""Triclosan disrupts gingivitis"" supported by the sentence: ""It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.""?",False, -16053270,Triclosan prevents allergic disease,3367,"Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.","Is the triple ""Triclosan prevents allergic disease"" supported by the sentence: ""Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.""?",False, -20585436,Povidone iodine affects stomatitis,3368,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Povidone iodine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, -22182083,Povidone iodine prevents Infection,3369,"Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.","Is the triple ""Povidone iodine prevents Infection"" supported by the sentence: ""Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.""?",False, -22061199,Povidone iodine prevents dental caries,3370,"OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.","Is the triple ""Povidone iodine prevents dental caries"" supported by the sentence: ""OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.""?",False, -20053240,Povidone iodine prevents keratitis,3371,"The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.","Is the triple ""Povidone iodine prevents keratitis"" supported by the sentence: ""The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.""?",False, -25268747,Vinblastine related to acute myeloid leukemia,3372,Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.,"Is the triple ""Vinblastine related to acute myeloid leukemia"" supported by the sentence: ""Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.""?",False, -24601120,Vinblastine related to leukemia,3373,Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.,"Is the triple ""Vinblastine related to leukemia"" supported by the sentence: ""Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.""?",False, -17518639,Vinblastine related to testicular cancer,3374,"Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.","Is the triple ""Vinblastine related to testicular cancer"" supported by the sentence: ""Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.""?",False, -11295996,Vinblastine related to melanoma,3375,"The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.","Is the triple ""Vinblastine related to melanoma"" supported by the sentence: ""The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.""?",False, -10629211,Vinblastine related to castration-resistant prostate carcinoma,3376,CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.,"Is the triple ""Vinblastine related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.""?",False, -9405598,Vinblastine related to glioma,3377,The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.,"Is the triple ""Vinblastine related to glioma"" supported by the sentence: ""The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.""?",False, -8887641,Vinblastine related to neoplasm,3378,"Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.","Is the triple ""Vinblastine related to neoplasm"" supported by the sentence: ""Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.""?",False, -8831546,Vinblastine related to renal cell carcinoma,3379,Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.,"Is the triple ""Vinblastine related to renal cell carcinoma"" supported by the sentence: ""Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.""?",False, -8248825,Vinblastine related to lymphoma,3380,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Vinblastine related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, -8201846,Vinblastine related to Langerhans cell histiocytosis,3381,[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].,"Is the triple ""Vinblastine related to Langerhans cell histiocytosis"" supported by the sentence: ""[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].""?",False, -7111310,Vinblastine related to Hodgkins lymphoma,3382,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Vinblastine related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, -22913920,Vinblastine causes neoplasm,3383,"Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.","Is the triple ""Vinblastine causes neoplasm"" supported by the sentence: ""Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.""?",False, -14498052,Vinblastine affects Langerhans cell histiocytosis,3384,"Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.","Is the triple ""Vinblastine affects Langerhans cell histiocytosis"" supported by the sentence: ""Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.""?",False, -12889760,Vinblastine affects renal cell carcinoma,3385,"In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.","Is the triple ""Vinblastine affects renal cell carcinoma"" supported by the sentence: ""In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.""?",False, -11723511,Vinblastine affects neoplasm,3386,"By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.","Is the triple ""Vinblastine affects neoplasm"" supported by the sentence: ""By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.""?",False, -19032862,Vinblastine disrupts neoplasm,3387,We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.,"Is the triple ""Vinblastine disrupts neoplasm"" supported by the sentence: ""We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.""?",False, -26195658,Desacetylvinblastine amide related to lymphoma,3388,Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.,"Is the triple ""Desacetylvinblastine amide related to lymphoma"" supported by the sentence: ""Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.""?",False, -26116904,Desacetylvinblastine amide related to acute lymphoblastic leukemia,3389,"Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.","Is the triple ""Desacetylvinblastine amide related to acute lymphoblastic leukemia"" supported by the sentence: ""Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.""?",False, -25980030,Desacetylvinblastine amide related to small cell lung carcinoma,3390,"Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.","Is the triple ""Desacetylvinblastine amide related to small cell lung carcinoma"" supported by the sentence: ""Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.""?",False, -26313629,Desacetylvinblastine amide affects neoplasm,3391,Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).,"Is the triple ""Desacetylvinblastine amide affects neoplasm"" supported by the sentence: ""Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).""?",False, -26201212,Desacetylvinblastine amide affects acute lymphoblastic leukemia,3392,A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.,"Is the triple ""Desacetylvinblastine amide affects acute lymphoblastic leukemia"" supported by the sentence: ""A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.""?",False, -26302410,Desacetylvinblastine amide prevents neoplasm,3393,"No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.","Is the triple ""Desacetylvinblastine amide prevents neoplasm"" supported by the sentence: ""No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.""?",False, -25951740,Diazoxide causes hyperinsulinism,3394,"[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].","Is the triple ""Diazoxide causes hyperinsulinism"" supported by the sentence: ""[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].""?",False, -17059197,Diazoxide causes hypoglycemia,3395,CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.,"Is the triple ""Diazoxide causes hypoglycemia"" supported by the sentence: ""CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.""?",False, -25817473,Diazoxide affects hypertensive disorder,3396,The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.,"Is the triple ""Diazoxide affects hypertensive disorder"" supported by the sentence: ""The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.""?",False, -20202762,Diazoxide affects obesity disorder,3397,"Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.","Is the triple ""Diazoxide affects obesity disorder"" supported by the sentence: ""Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.""?",False, -11393233,Diazoxide affects hyperinsulinism,3398,Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).,"Is the triple ""Diazoxide affects hyperinsulinism"" supported by the sentence: ""Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).""?",False, -8184004,Diazoxide affects hypoglycemia,3399,"An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.","Is the triple ""Diazoxide affects hypoglycemia"" supported by the sentence: ""An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.""?",False, -9572369,Diazoxide disrupts hyperinsulinism,3400,"CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.","Is the triple ""Diazoxide disrupts hyperinsulinism"" supported by the sentence: ""CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.""?",False, -26286810,Diazoxide prevents hypoglycemia,3401,Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.,"Is the triple ""Diazoxide prevents hypoglycemia"" supported by the sentence: ""Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.""?",False, -22404640,Diazoxide prevents hypertensive disorder,3402,Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.,"Is the triple ""Diazoxide prevents hypertensive disorder"" supported by the sentence: ""Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.""?",False, -19200973,Diazoxide prevents obesity disorder,3403,OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.,"Is the triple ""Diazoxide prevents obesity disorder"" supported by the sentence: ""OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.""?",False, -16737667,Diazoxide predisposes hypoglycemia,3404,Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.,"Is the triple ""Diazoxide predisposes hypoglycemia"" supported by the sentence: ""Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.""?",False, -14267417,Pantoprazole affects gastroesophageal reflux disease,3405,Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).,"Is the triple ""Pantoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).""?",False, -12160514,Pantoprazole prevents active peptic ulcer disease,3406,"Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.","Is the triple ""Pantoprazole prevents active peptic ulcer disease"" supported by the sentence: ""Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.""?",False, -8423273,Pantoprazole prevents peptic ulcer disease,3407,"Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.","Is the triple ""Pantoprazole prevents peptic ulcer disease"" supported by the sentence: ""Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.""?",False, -7509578,Pantoprazole prevents ulcer disease,3408,"In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.","Is the triple ""Pantoprazole prevents ulcer disease"" supported by the sentence: ""In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.""?",False, -21088628,Pantoprazole predisposes active peptic ulcer disease,3409,"Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.","Is the triple ""Pantoprazole predisposes active peptic ulcer disease"" supported by the sentence: ""Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.""?",False, -20047688,Lansoprazole causes gastric ulcer,3410,"AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.","Is the triple ""Lansoprazole causes gastric ulcer"" supported by the sentence: ""AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.""?",False, -26544602,Lansoprazole affects peptic ulcer disease,3411,Effect of lansoprazole on peptic ulcers.,"Is the triple ""Lansoprazole affects peptic ulcer disease"" supported by the sentence: ""Effect of lansoprazole on peptic ulcers.""?",False, -11547923,Lansoprazole affects gastroesophageal reflux disease,3412,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Lansoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, -10008124,Lansoprazole affects peptic esophagitis,3413,"When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.","Is the triple ""Lansoprazole affects peptic esophagitis"" supported by the sentence: ""When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.""?",False, -7314434,Lansoprazole affects Helicobacter pylori infectious disease,3414,"Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.","Is the triple ""Lansoprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.""?",False, -9466998,Lansoprazole disrupts gastroesophageal reflux disease,3415,"In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).","Is the triple ""Lansoprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).""?",False, -20033093,Lansoprazole prevents peptic ulcer disease,3416,"CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.","Is the triple ""Lansoprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.""?",False, -15339719,Lansoprazole prevents duodenal ulcer,3417,"The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.","Is the triple ""Lansoprazole prevents duodenal ulcer"" supported by the sentence: ""The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.""?",False, -9335785,Lansoprazole prevents gastric ulcer,3418,"CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.","Is the triple ""Lansoprazole prevents gastric ulcer"" supported by the sentence: ""CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.""?",False, -8183428,Lansoprazole prevents gastroesophageal reflux disease,3419,"In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.","Is the triple ""Lansoprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.""?",False, -27664803,Lansoprazole exacerbates gastritis,3420,RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.,"Is the triple ""Lansoprazole exacerbates gastritis"" supported by the sentence: ""RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.""?",False, -10008126,Lansoprazole predisposes gastroesophageal reflux disease,3421,AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.,"Is the triple ""Lansoprazole predisposes gastroesophageal reflux disease"" supported by the sentence: ""AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.""?",False, -10345128,Omeprazole subclass of Omeprazole sulfone,3422,"The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.","Is the triple ""Omeprazole subclass of Omeprazole sulfone"" supported by the sentence: ""The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.""?",False, -8512321,Omeprazole subclass of Hydroxyomeprazole,3423,"The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.","Is the triple ""Omeprazole subclass of Hydroxyomeprazole"" supported by the sentence: ""The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.""?",False, -27115212,Omeprazole related to Omeprazole sulfone,3424,"Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.","Is the triple ""Omeprazole related to Omeprazole sulfone"" supported by the sentence: ""Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.""?",False, -12365583,Omeprazole related to gastric ulcer,3425,Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?,"Is the triple ""Omeprazole related to gastric ulcer"" supported by the sentence: ""Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?""?",False, -7744216,Omeprazole related to Hydroxyomeprazole,3426,"Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.","Is the triple ""Omeprazole related to Hydroxyomeprazole"" supported by the sentence: ""Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.""?",False, -26722672,Omeprazole physically interacts with Omeprazole sulfone,3427,"The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.","Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.""?",False, -9932953,Omeprazole physically interacts with Hydroxyomeprazole,3428,"Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).","Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).""?",False, -22198908,Omeprazole physically interacts with Omeprazole sulfone,3429,Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.,"Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.""?",False, -13085286,Omeprazole physically interacts with Hydroxyomeprazole,3430,The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.,"Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.""?",False, -27703677,Omeprazole causes anemia,3431,"Pyrexia, anaemia and acute renal failure secondary to omeprazole.","Is the triple ""Omeprazole causes anemia"" supported by the sentence: ""Pyrexia, anaemia and acute renal failure secondary to omeprazole.""?",False, -27298440,Omeprazole causes Hemorrhage,3432,"Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.","Is the triple ""Omeprazole causes Hemorrhage"" supported by the sentence: ""Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.""?",False, -24514538,Omeprazole causes peptic ulcer disease,3433,Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.,"Is the triple ""Omeprazole causes peptic ulcer disease"" supported by the sentence: ""Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.""?",False, -19641302,Omeprazole causes gastroesophageal reflux disease,3434,"The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.","Is the triple ""Omeprazole causes gastroesophageal reflux disease"" supported by the sentence: ""The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.""?",False, -15956000,Omeprazole causes esophagitis,3435,"Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.","Is the triple ""Omeprazole causes esophagitis"" supported by the sentence: ""Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.""?",False, -12187782,Omeprazole causes ulcer disease,3436,"Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.","Is the triple ""Omeprazole causes ulcer disease"" supported by the sentence: ""Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.""?",False, -11135889,Omeprazole causes injury,3437,"DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.","Is the triple ""Omeprazole causes injury"" supported by the sentence: ""DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.""?",False, -10813876,Omeprazole causes Cough,3438,Omeprazole-induced intractable cough.,"Is the triple ""Omeprazole causes Cough"" supported by the sentence: ""Omeprazole-induced intractable cough.""?",False, -8871402,Omeprazole causes gastric ulcer,3439,"Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.","Is the triple ""Omeprazole causes gastric ulcer"" supported by the sentence: ""Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.""?",False, -7272148,Omeprazole causes duodenal ulcer,3440,"Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.","Is the triple ""Omeprazole causes duodenal ulcer"" supported by the sentence: ""Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.""?",False, -27758339,Omeprazole affects Zollinger-Ellison syndrome,3441,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects Zollinger-Ellison syndrome"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, -27758338,Omeprazole affects peptic ulcer disease,3442,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, -27758337,Omeprazole affects peptic esophagitis,3443,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, -27733079,Omeprazole affects peptic esophagitis,3444,The effect of treating reflux oesophagitis with omeprazole on quality of life.,"Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""The effect of treating reflux oesophagitis with omeprazole on quality of life.""?",False, -27346919,Omeprazole affects peptic ulcer disease,3445,[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].,"Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].""?",False, -22440533,Omeprazole affects anemia,3446,Prolonged use of omeprazole may involve in inducing anemia.,"Is the triple ""Omeprazole affects anemia"" supported by the sentence: ""Prolonged use of omeprazole may involve in inducing anemia.""?",False, -18634760,Omeprazole affects Pain,3447,"Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.","Is the triple ""Omeprazole affects Pain"" supported by the sentence: ""Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.""?",False, -17967745,Omeprazole affects injury,3448,Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.,"Is the triple ""Omeprazole affects injury"" supported by the sentence: ""Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.""?",False, -12114858,Omeprazole affects ulcer disease,3449,"Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.""?",False, -11576921,Omeprazole affects Hydroxyomeprazole,3450,CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.""?",False, -10321262,Omeprazole affects duodenal ulcer,3451,"46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.","Is the triple ""Omeprazole affects duodenal ulcer"" supported by the sentence: ""46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.""?",False, -9976497,Omeprazole affects gastric ulcer,3452,A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.,"Is the triple ""Omeprazole affects gastric ulcer"" supported by the sentence: ""A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.""?",False, -8694897,Omeprazole affects Helicobacter pylori infectious disease,3453,"The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.","Is the triple ""Omeprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.""?",False, -8349380,Omeprazole affects Hemorrhage,3454,"CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.","Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.""?",False, -8349375,Omeprazole affects Hemorrhage,3455,Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, -7653505,Omeprazole affects gastroesophageal reflux disease,3456,The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.,"Is the triple ""Omeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.""?",False, -7572363,Omeprazole affects ulcer disease,3457,"Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".""?",False, -14345083,Omeprazole affects Hydroxyomeprazole,3458,The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.""?",False, -26726289,Omeprazole disrupts gastroesophageal reflux disease,3459,"A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.","Is the triple ""Omeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.""?",False, -26000029,Omeprazole disrupts Zollinger-Ellison syndrome,3460,Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.,"Is the triple ""Omeprazole disrupts Zollinger-Ellison syndrome"" supported by the sentence: ""Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.""?",False, -20129793,Omeprazole disrupts Barrett esophagus,3461,"Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.","Is the triple ""Omeprazole disrupts Barrett esophagus"" supported by the sentence: ""Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.""?",False, -19299462,Omeprazole disrupts active peptic ulcer disease,3462,"The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.","Is the triple ""Omeprazole disrupts active peptic ulcer disease"" supported by the sentence: ""The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.""?",False, -15524012,Omeprazole disrupts peptic ulcer disease,3463,Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.,"Is the triple ""Omeprazole disrupts peptic ulcer disease"" supported by the sentence: ""Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.""?",False, -13078646,Omeprazole disrupts ulcer disease,3464,"The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.","Is the triple ""Omeprazole disrupts ulcer disease"" supported by the sentence: ""The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.""?",False, -10891179,Omeprazole disrupts gastric ulcer,3465,"POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.","Is the triple ""Omeprazole disrupts gastric ulcer"" supported by the sentence: ""POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.""?",False, -10776897,Omeprazole disrupts duodenal ulcer,3466,"(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.","Is the triple ""Omeprazole disrupts duodenal ulcer"" supported by the sentence: ""(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.""?",False, -8884340,Omeprazole disrupts esophagitis,3467,"The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).","Is the triple ""Omeprazole disrupts esophagitis"" supported by the sentence: ""The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).""?",False, -27690262,Omeprazole prevents Helicobacter pylori infectious disease,3468,"To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.","Is the triple ""Omeprazole prevents Helicobacter pylori infectious disease"" supported by the sentence: ""To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.""?",False, -27025148,Omeprazole prevents Cough,3469,"Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.","Is the triple ""Omeprazole prevents Cough"" supported by the sentence: ""Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.""?",False, -26715213,Omeprazole prevents Pain,3470,Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.,"Is the triple ""Omeprazole prevents Pain"" supported by the sentence: ""Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.""?",False, -16929638,Omeprazole prevents esophagitis,3471,"Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.","Is the triple ""Omeprazole prevents esophagitis"" supported by the sentence: ""Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.""?",False, -15601042,Omeprazole prevents active peptic ulcer disease,3472,Omeprazole even can decrease gastro-intestinal bleeding in those patients.,"Is the triple ""Omeprazole prevents active peptic ulcer disease"" supported by the sentence: ""Omeprazole even can decrease gastro-intestinal bleeding in those patients.""?",False, -9292674,Omeprazole prevents peptic ulcer disease,3473,"CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.","Is the triple ""Omeprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.""?",False, -8884338,Omeprazole prevents peptic esophagitis,3474,IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.,"Is the triple ""Omeprazole prevents peptic esophagitis"" supported by the sentence: ""IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.""?",False, -8341772,Omeprazole prevents duodenal ulcer,3475,The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].,"Is the triple ""Omeprazole prevents duodenal ulcer"" supported by the sentence: ""The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].""?",False, -8169375,Omeprazole prevents injury,3476,"The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).","Is the triple ""Omeprazole prevents injury"" supported by the sentence: ""The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).""?",False, -7646984,Omeprazole prevents gastric ulcer,3477,Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.,"Is the triple ""Omeprazole prevents gastric ulcer"" supported by the sentence: ""Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.""?",False, -7653510,Omeprazole prevents gastroesophageal reflux disease,3478,"CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.","Is the triple ""Omeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.""?",False, -7332307,Omeprazole prevents ulcer disease,3479,Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.,"Is the triple ""Omeprazole prevents ulcer disease"" supported by the sentence: ""Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.""?",False, -24752030,Omeprazole predisposes type 2 diabetes mellitus,3480,"Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.","Is the triple ""Omeprazole predisposes type 2 diabetes mellitus"" supported by the sentence: ""Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.""?",False, -21309680,Omeprazole predisposes melanoma,3481,"The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.","Is the triple ""Omeprazole predisposes melanoma"" supported by the sentence: ""The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.""?",False, -20838741,Omeprazole predisposes Barrett esophagus,3482,"Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.","Is the triple ""Omeprazole predisposes Barrett esophagus"" supported by the sentence: ""Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.""?",False, -12649375,Rabeprazole affects infectious disease,3483,"METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).","Is the triple ""Rabeprazole affects infectious disease"" supported by the sentence: ""METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).""?",False, -11547924,Rabeprazole affects gastroesophageal reflux disease,3484,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Rabeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, -15461842,Rabeprazole disrupts gastroesophageal reflux disease,3485,CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.,"Is the triple ""Rabeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.""?",False, -16244495,Rabeprazole prevents peptic ulcer disease,3486,"We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.","Is the triple ""Rabeprazole prevents peptic ulcer disease"" supported by the sentence: ""We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.""?",False, -15354267,Rabeprazole prevents active peptic ulcer disease,3487,The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.,"Is the triple ""Rabeprazole prevents active peptic ulcer disease"" supported by the sentence: ""The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.""?",False, -8397732,Rabeprazole prevents gastroesophageal reflux disease,3488,RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).,"Is the triple ""Rabeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).""?",False, -23526790,Esomeprazole causes active peptic ulcer disease,3489,"Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.","Is the triple ""Esomeprazole causes active peptic ulcer disease"" supported by the sentence: ""Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.""?",False, -20333475,Esomeprazole causes preeclampsia,3490,We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.,"Is the triple ""Esomeprazole causes preeclampsia"" supported by the sentence: ""We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.""?",False, -15271081,Esomeprazole causes gastric ulcer,3491,The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.,"Is the triple ""Esomeprazole causes gastric ulcer"" supported by the sentence: ""The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.""?",False, -22638872,Esomeprazole affects neoplasm,3492,"Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.","Is the triple ""Esomeprazole affects neoplasm"" supported by the sentence: ""Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.""?",False, -20180848,Esomeprazole affects preeclampsia,3493,Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.,"Is the triple ""Esomeprazole affects preeclampsia"" supported by the sentence: ""Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.""?",False, -19360632,Esomeprazole affects ulcer disease,3494,Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.,"Is the triple ""Esomeprazole affects ulcer disease"" supported by the sentence: ""Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.""?",False, -18357402,Esomeprazole affects dyspepsia,3495,"Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.","Is the triple ""Esomeprazole affects dyspepsia"" supported by the sentence: ""Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.""?",False, -14247859,Esomeprazole affects gastric ulcer,3496,"In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.","Is the triple ""Esomeprazole affects gastric ulcer"" supported by the sentence: ""In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.""?",False, -12902689,Esomeprazole affects Hemorrhage,3497,The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, -12902688,Esomeprazole affects Hemorrhage,3498,Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, -12527967,Esomeprazole affects gastroesophageal reflux disease,3499,CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.,"Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.""?",False, -12015567,Esomeprazole affects gastroesophageal reflux disease,3500,"This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.","Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.""?",False, -10805094,Esomeprazole disrupts gastroesophageal reflux disease,3501,"The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.","Is the triple ""Esomeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.""?",False, -15938697,Esomeprazole prevents gastric ulcer,3502,"Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.","Is the triple ""Esomeprazole prevents gastric ulcer"" supported by the sentence: ""Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.""?",False, -14015294,Esomeprazole prevents gastroesophageal reflux disease,3503,CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.,"Is the triple ""Esomeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.""?",False, -13576722,Esomeprazole prevents peptic ulcer disease,3504,Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.,"Is the triple ""Esomeprazole prevents peptic ulcer disease"" supported by the sentence: ""Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.""?",False, -12321750,Esomeprazole prevents ulcer disease,3505,"CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.","Is the triple ""Esomeprazole prevents ulcer disease"" supported by the sentence: ""CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.""?",False, -10396538,Roflumilast related to asthma,3506,Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.,"Is the triple ""Roflumilast related to asthma"" supported by the sentence: ""Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.""?",False, -21017284,Roflumilast causes chronic obstructive pulmonary disease,3507,"Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.","Is the triple ""Roflumilast causes chronic obstructive pulmonary disease"" supported by the sentence: ""Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.""?",False, -21116198,Roflumilast affects obesity disorder,3508,"Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.","Is the triple ""Roflumilast affects obesity disorder"" supported by the sentence: ""Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.""?",False, -12290110,Roflumilast affects chronic obstructive pulmonary disease,3509,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects chronic obstructive pulmonary disease"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, -12290109,Roflumilast affects asthma,3510,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects asthma"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, -22432515,Roflumilast disrupts schizophrenia,3511,"CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.","Is the triple ""Roflumilast disrupts schizophrenia"" supported by the sentence: ""CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.""?",False, -24502817,Roflumilast prevents obesity disorder,3512,"RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.","Is the triple ""Roflumilast prevents obesity disorder"" supported by the sentence: ""RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.""?",False, -17763098,Roflumilast prevents diabetic kidney disease,3513,Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.,"Is the triple ""Roflumilast prevents diabetic kidney disease"" supported by the sentence: ""Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.""?",False, -15955656,Roflumilast prevents chronic obstructive pulmonary disease,3514,"Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.","Is the triple ""Roflumilast prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.""?",False, -8310806,Meperidine causes Pain,3515,OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.,"Is the triple ""Meperidine causes Pain"" supported by the sentence: ""OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.""?",False, -26434893,Meperidine affects Pain,3516,The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.,"Is the triple ""Meperidine affects Pain"" supported by the sentence: ""The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.""?",False, -18658715,Meperidine affects Pain,3517,"Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.","Is the triple ""Meperidine affects Pain"" supported by the sentence: ""Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.""?",False, -8345324,Meperidine prevents Pain,3518,The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.,"Is the triple ""Meperidine prevents Pain"" supported by the sentence: ""The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.""?",False, -21672389,Ketobemidone affects Pain,3519,"Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.","Is the triple ""Ketobemidone affects Pain"" supported by the sentence: ""Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.""?",False, -11850764,Travoprost related to ocular hypertension,3520,"CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.","Is the triple ""Travoprost related to ocular hypertension"" supported by the sentence: ""CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.""?",False, -12116829,Travoprost physically interacts with prostanoid FP receptor,3521,"PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.","Is the triple ""Travoprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.""?",False, -18294152,Travoprost affects ocular hypertension,3522,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects ocular hypertension"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, -18294151,Travoprost affects glaucoma,3523,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects glaucoma"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, -10166996,Travoprost prevents ocular hypertension,3524,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents ocular hypertension"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, -10166995,Travoprost prevents open-angle glaucoma,3525,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents open-angle glaucoma"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, -17904574,Tafluprost related to glaucoma,3526,Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.,"Is the triple ""Tafluprost related to glaucoma"" supported by the sentence: ""Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.""?",False, -15304153,Tafluprost related to ocular hypertension,3527,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to ocular hypertension"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, -15304152,Tafluprost related to open-angle glaucoma,3528,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to open-angle glaucoma"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, -14941475,Tafluprost physically interacts with prostanoid FP receptor,3529,Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.,"Is the triple ""Tafluprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.""?",False, -14941474,Tafluprost disrupts ocular hypertension,3530,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts ocular hypertension"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, -14941473,Tafluprost disrupts open-angle glaucoma,3531,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts open-angle glaucoma"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, -14231277,Ramelteon affects insomnia,3532,"Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.","Is the triple ""Ramelteon affects insomnia"" supported by the sentence: ""Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.""?",False, -21718213,Ramelteon prevents sleep-wake disorder,3533,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Ramelteon prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, -22873470,Melatonin related to acute kidney failure,3534,"Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.","Is the triple ""Melatonin related to acute kidney failure"" supported by the sentence: ""Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.""?",False, -22002909,Melatonin related to metabolic disease,3535,"Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.","Is the triple ""Melatonin related to metabolic disease"" supported by the sentence: ""Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.""?",False, -21777340,Melatonin related to Cognitive impairment,3536,"Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.","Is the triple ""Melatonin related to Cognitive impairment"" supported by the sentence: ""Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.""?",False, -18920431,Melatonin related to burn,3537,"CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.","Is the triple ""Melatonin related to burn"" supported by the sentence: ""CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.""?",False, -18846352,Melatonin related to skin disorder,3538,And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.,"Is the triple ""Melatonin related to skin disorder"" supported by the sentence: ""And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.""?",False, -18613354,Melatonin related to Neonatal sepsis,3539,Use of melatonin as an adjuvant therapy in neonatal sepsis.,"Is the triple ""Melatonin related to Neonatal sepsis"" supported by the sentence: ""Use of melatonin as an adjuvant therapy in neonatal sepsis.""?",False, -18189253,Melatonin related to necrotizing enterocolitis,3540,"This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.","Is the triple ""Melatonin related to necrotizing enterocolitis"" supported by the sentence: ""This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.""?",False, -17471678,"Melatonin related to dermatitis, atopic",3541,"To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.","Is the triple ""Melatonin related to dermatitis, atopic"" supported by the sentence: ""To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.""?",False, -17103445,Melatonin related to obstructive sleep apnea syndrome,3542,Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?,"Is the triple ""Melatonin related to obstructive sleep apnea syndrome"" supported by the sentence: ""Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?""?",False, -16423098,Melatonin related to periodontitis,3543,Previous studies reported decreased salivary and serum melatonin levels in periodontitis.,"Is the triple ""Melatonin related to periodontitis"" supported by the sentence: ""Previous studies reported decreased salivary and serum melatonin levels in periodontitis.""?",False, -16022569,Melatonin related to metabolic syndrome X,3544,"In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.","Is the triple ""Melatonin related to metabolic syndrome X"" supported by the sentence: ""In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.""?",False, -15882605,Melatonin related to enuresis,3545,"Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.","Is the triple ""Melatonin related to enuresis"" supported by the sentence: ""Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.""?",False, -15709123,Melatonin related to fibromyalgia,3546,Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.,"Is the triple ""Melatonin related to fibromyalgia"" supported by the sentence: ""Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.""?",False, -15665905,"Melatonin related to attention deficit hyperactivity disorder, inattentive type",3547,These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.,"Is the triple ""Melatonin related to attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.""?",False, -14933527,Melatonin related to autism spectrum disorder,3548,"Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.","Is the triple ""Melatonin related to autism spectrum disorder"" supported by the sentence: ""Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.""?",False, -14875890,Melatonin related to pervasive developmental disorder,3549,"Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.","Is the triple ""Melatonin related to pervasive developmental disorder"" supported by the sentence: ""Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.""?",False, -14786958,Melatonin related to gastroesophageal reflux disease,3550,The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.,"Is the triple ""Melatonin related to gastroesophageal reflux disease"" supported by the sentence: ""The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.""?",False, -13857052,Melatonin related to ulcerative colitis,3551,In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.,"Is the triple ""Melatonin related to ulcerative colitis"" supported by the sentence: ""In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.""?",False, -13491215,Melatonin related to diabetes mellitus,3552,(v) Melatonin influences diabetes and associated metabolic disturbances.,"Is the triple ""Melatonin related to diabetes mellitus"" supported by the sentence: ""(v) Melatonin influences diabetes and associated metabolic disturbances.""?",False, -13407170,Melatonin related to periodontal disorder,3553,BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.,"Is the triple ""Melatonin related to periodontal disorder"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.""?",False, -13365823,Melatonin related to tooth disorder,3554,"Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.","Is the triple ""Melatonin related to tooth disorder"" supported by the sentence: ""Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.""?",False, -12843346,Melatonin related to melanoma,3555,"Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.","Is the triple ""Melatonin related to melanoma"" supported by the sentence: ""Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.""?",False, -12132104,Melatonin related to irritable bowel syndrome,3556,AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).,"Is the triple ""Melatonin related to irritable bowel syndrome"" supported by the sentence: ""AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).""?",False, -11584899,Melatonin related to brain ischemia,3557,"Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.","Is the triple ""Melatonin related to brain ischemia"" supported by the sentence: ""Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.""?",False, -11533403,Melatonin related to hypertensive disorder,3558,"Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.","Is the triple ""Melatonin related to hypertensive disorder"" supported by the sentence: ""Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.""?",False, -11319171,Melatonin related to Pain,3559,These results suggest a proalgesic role of endogenous melatonin in tonic pain.,"Is the triple ""Melatonin related to Pain"" supported by the sentence: ""These results suggest a proalgesic role of endogenous melatonin in tonic pain.""?",False, -11137637,Melatonin related to essential hypertension,3560,"OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.","Is the triple ""Melatonin related to essential hypertension"" supported by the sentence: ""OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.""?",False, -10685850,Melatonin related to major depressive disorder,3561,"Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.","Is the triple ""Melatonin related to major depressive disorder"" supported by the sentence: ""Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.""?",False, -10528037,Melatonin related to multiple sclerosis,3562,"Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.","Is the triple ""Melatonin related to multiple sclerosis"" supported by the sentence: ""Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.""?",False, -10477010,Melatonin related to non-small cell lung carcinoma,3563,"On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.","Is the triple ""Melatonin related to non-small cell lung carcinoma"" supported by the sentence: ""On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.""?",False, -10371972,Melatonin related to delirium,3564,"Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.","Is the triple ""Melatonin related to delirium"" supported by the sentence: ""Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.""?",False, -10204563,Melatonin related to depressive disorder,3565,"Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.","Is the triple ""Melatonin related to depressive disorder"" supported by the sentence: ""Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.""?",False, -9947492,Melatonin related to myocardial infarction,3566,Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.,"Is the triple ""Melatonin related to myocardial infarction"" supported by the sentence: ""Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.""?",False, -9516882,Melatonin related to Parkinson disease,3567,Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.,"Is the triple ""Melatonin related to Parkinson disease"" supported by the sentence: ""Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.""?",False, -9086006,Melatonin related to ischemia reperfusion injury,3568,"Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.","Is the triple ""Melatonin related to ischemia reperfusion injury"" supported by the sentence: ""Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.""?",False, -9074687,Melatonin related to Sepsis,3569,"These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.","Is the triple ""Melatonin related to Sepsis"" supported by the sentence: ""These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.""?",False, -8867365,Melatonin related to schizophrenia,3570,"CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.","Is the triple ""Melatonin related to schizophrenia"" supported by the sentence: ""CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.""?",False, -8780387,Melatonin related to insomnia,3571,"The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.","Is the triple ""Melatonin related to insomnia"" supported by the sentence: ""The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.""?",False, -8686098,Melatonin related to dementia,3572,OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.,"Is the triple ""Melatonin related to dementia"" supported by the sentence: ""OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.""?",False, -8623112,Melatonin related to migraine disorder,3573,"This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.","Is the triple ""Melatonin related to migraine disorder"" supported by the sentence: ""This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.""?",False, -7795396,Melatonin related to injury,3574,"Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.","Is the triple ""Melatonin related to injury"" supported by the sentence: ""Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.""?",False, -7482169,Melatonin related to neoplasm,3575,Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.,"Is the triple ""Melatonin related to neoplasm"" supported by the sentence: ""Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.""?",False, -7440685,Melatonin related to Fatigue,3576,"Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.","Is the triple ""Melatonin related to Fatigue"" supported by the sentence: ""Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.""?",False, -7185935,Melatonin related to epilepsy,3577,Melatonin in epilepsy: first results of replacement therapy and first clinical results.,"Is the triple ""Melatonin related to epilepsy"" supported by the sentence: ""Melatonin in epilepsy: first results of replacement therapy and first clinical results.""?",False, -7185921,Melatonin related to sleep-wake disorder,3578,Melatonin in circadian sleep disorders in the blind.,"Is the triple ""Melatonin related to sleep-wake disorder"" supported by the sentence: ""Melatonin in circadian sleep disorders in the blind.""?",False, -26987553,Melatonin causes Fatigue,3579,"Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.","Is the triple ""Melatonin causes Fatigue"" supported by the sentence: ""Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.""?",False, -24500836,Melatonin causes anxiety,3580,"Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.","Is the triple ""Melatonin causes anxiety"" supported by the sentence: ""Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.""?",False, -22662368,Melatonin causes dementia,3581,"A chronic melatonin deficiency, with loss of dreams, could cause dementia.","Is the triple ""Melatonin causes dementia"" supported by the sentence: ""A chronic melatonin deficiency, with loss of dreams, could cause dementia.""?",False, -21258564,Melatonin causes multiple sclerosis,3582,"A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.","Is the triple ""Melatonin causes multiple sclerosis"" supported by the sentence: ""A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.""?",False, -19886996,Melatonin causes Cognitive impairment,3583,"However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.","Is the triple ""Melatonin causes Cognitive impairment"" supported by the sentence: ""However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.""?",False, -19573910,Melatonin causes periodontitis,3584,Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.,"Is the triple ""Melatonin causes periodontitis"" supported by the sentence: ""Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.""?",False, -17837306,Melatonin causes metabolic disease,3585,"This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.","Is the triple ""Melatonin causes metabolic disease"" supported by the sentence: ""This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.""?",False, -17714427,Melatonin causes myocardial infarction,3586,The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.,"Is the triple ""Melatonin causes myocardial infarction"" supported by the sentence: ""The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.""?",False, -16705153,Melatonin causes Sepsis,3587,Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.,"Is the triple ""Melatonin causes Sepsis"" supported by the sentence: ""Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.""?",False, -15644359,Melatonin causes gastroesophageal reflux disease,3588,Low levels of melatonin lead to gastroesophageal reflux disease (GERD).,"Is the triple ""Melatonin causes gastroesophageal reflux disease"" supported by the sentence: ""Low levels of melatonin lead to gastroesophageal reflux disease (GERD).""?",False, -14831403,Melatonin causes periodontal disorder,3589,"BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.","Is the triple ""Melatonin causes periodontal disorder"" supported by the sentence: ""BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.""?",False, -14171289,Melatonin causes Parkinson disease,3590,"Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.","Is the triple ""Melatonin causes Parkinson disease"" supported by the sentence: ""Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.""?",False, -14078373,Melatonin causes hypertensive disorder,3591,Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.,"Is the triple ""Melatonin causes hypertensive disorder"" supported by the sentence: ""Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.""?",False, -13896033,Melatonin causes breast neoplasm,3592,"Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.","Is the triple ""Melatonin causes breast neoplasm"" supported by the sentence: ""Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.""?",False, -13361926,Melatonin causes ischemia reperfusion injury,3593,The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.,"Is the triple ""Melatonin causes ischemia reperfusion injury"" supported by the sentence: ""The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.""?",False, -13039360,Melatonin causes epilepsy,3594,"In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.","Is the triple ""Melatonin causes epilepsy"" supported by the sentence: ""In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.""?",False, -12762592,Melatonin causes enuresis,3595,"CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.","Is the triple ""Melatonin causes enuresis"" supported by the sentence: ""CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.""?",False, -12275569,Melatonin causes diabetes mellitus,3596,"Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.","Is the triple ""Melatonin causes diabetes mellitus"" supported by the sentence: ""Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.""?",False, -12071557,Melatonin causes insomnia,3597,"Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.","Is the triple ""Melatonin causes insomnia"" supported by the sentence: ""Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.""?",False, -10432083,Melatonin causes migraine disorder,3598,"The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.","Is the triple ""Melatonin causes migraine disorder"" supported by the sentence: ""The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.""?",False, -10432067,Melatonin causes schizophrenia,3599,"I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.","Is the triple ""Melatonin causes schizophrenia"" supported by the sentence: ""I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.""?",False, -9114525,Melatonin causes neoplasm,3600,"Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.","Is the triple ""Melatonin causes neoplasm"" supported by the sentence: ""Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.""?",False, -8785660,Melatonin causes depressive disorder,3601,The melatonin-induced depression was followed by a slow recovery phase.,"Is the triple ""Melatonin causes depressive disorder"" supported by the sentence: ""The melatonin-induced depression was followed by a slow recovery phase.""?",False, -8291971,Melatonin causes injury,3602,"Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.","Is the triple ""Melatonin causes injury"" supported by the sentence: ""Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.""?",False, -25620630,Melatonin affects Fatigue,3603,"Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.""?",False, -25259613,Melatonin affects atrial fibrillation,3604,"Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.","Is the triple ""Melatonin affects atrial fibrillation"" supported by the sentence: ""Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.""?",False, -24144792,Melatonin affects myocardial infarction,3605,"RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.","Is the triple ""Melatonin affects myocardial infarction"" supported by the sentence: ""RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.""?",False, -24094187,Melatonin affects major depressive disorder,3606,"A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.","Is the triple ""Melatonin affects major depressive disorder"" supported by the sentence: ""A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.""?",False, -23101890,Melatonin affects periodontitis,3607,The Effect of Melatonin on Periodontitis.,"Is the triple ""Melatonin affects periodontitis"" supported by the sentence: ""The Effect of Melatonin on Periodontitis.""?",False, -22037016,Melatonin affects diabetes mellitus,3608,Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.,"Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.""?",False, -21523229,Melatonin affects anxiety,3609,The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.,"Is the triple ""Melatonin affects anxiety"" supported by the sentence: ""The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.""?",False, -21046382,Melatonin affects non-small cell lung carcinoma,3610,"Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.","Is the triple ""Melatonin affects non-small cell lung carcinoma"" supported by the sentence: ""Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.""?",False, -20888328,Melatonin affects autism spectrum disorder,3611,"In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.","Is the triple ""Melatonin affects autism spectrum disorder"" supported by the sentence: ""In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.""?",False, -18858036,Melatonin affects Cognitive impairment,3612,Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.,"Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.""?",False, -18703578,Melatonin affects Marchiafava-Bignami disease,3613,"The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.","Is the triple ""Melatonin affects Marchiafava-Bignami disease"" supported by the sentence: ""The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.""?",False, -18605461,Melatonin affects Neonatal sepsis,3614,CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.""?",False, -18605459,Melatonin affects Neonatal sepsis,3615,Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.""?",False, -18111864,Melatonin affects Hemorrhage,3616,Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.,"Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.""?",False, -17774103,Melatonin affects fibromyalgia,3617,"Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).","Is the triple ""Melatonin affects fibromyalgia"" supported by the sentence: ""Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).""?",False, -17471677,"Melatonin affects dermatitis, atopic",3618,Alterations of melatonin secretion in atopic eczema.,"Is the triple ""Melatonin affects dermatitis, atopic"" supported by the sentence: ""Alterations of melatonin secretion in atopic eczema.""?",False, -17402992,Melatonin affects Fatigue,3619,"Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.""?",False, -17199486,Melatonin affects Sepsis,3620,Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.,"Is the triple ""Melatonin affects Sepsis"" supported by the sentence: ""Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.""?",False, -17103446,Melatonin affects obstructive sleep apnea syndrome,3621,The data on the involvement of melatonin in OSAS are rare.,"Is the triple ""Melatonin affects obstructive sleep apnea syndrome"" supported by the sentence: ""The data on the involvement of melatonin in OSAS are rare.""?",False, -17112614,Melatonin affects ulcerative colitis,3622,Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.,"Is the triple ""Melatonin affects ulcerative colitis"" supported by the sentence: ""Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.""?",False, -16898660,Melatonin affects Cognitive impairment,3623,"Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.""?",False, -16300651,Melatonin affects depressive disorder,3624,"Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.""?",False, -16293202,Melatonin affects Hemorrhage,3625,"Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.","Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.""?",False, -16189615,Melatonin affects Cognitive impairment,3626,"The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.""?",False, -15390003,Melatonin affects delirium,3627,Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.,"Is the triple ""Melatonin affects delirium"" supported by the sentence: ""Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.""?",False, -14400565,Melatonin affects burn,3628,Effect of melatonin on burn-induced gastric mucosal injury in rats.,"Is the triple ""Melatonin affects burn"" supported by the sentence: ""Effect of melatonin on burn-induced gastric mucosal injury in rats.""?",False, -14333232,Melatonin affects schizophrenia,3629,"""Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.","Is the triple ""Melatonin affects schizophrenia"" supported by the sentence: """"Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.""?",False, -13430046,Melatonin affects epilepsy,3630,"Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.","Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.""?",False, -13158859,Melatonin affects tooth disorder,3631,"RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.","Is the triple ""Melatonin affects tooth disorder"" supported by the sentence: ""RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.""?",False, -12620684,Melatonin affects melanoma,3632,Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.,"Is the triple ""Melatonin affects melanoma"" supported by the sentence: ""Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.""?",False, -12473519,Melatonin affects Parkinson disease,3633,Melatonin secretion has been found to be altered in AD and PD.,"Is the triple ""Melatonin affects Parkinson disease"" supported by the sentence: ""Melatonin secretion has been found to be altered in AD and PD.""?",False, -11739216,Melatonin affects sleep-wake disorder,3634,"To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).","Is the triple ""Melatonin affects sleep-wake disorder"" supported by the sentence: ""To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).""?",False, -11451669,Melatonin affects depressive disorder,3635,"Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.""?",False, -10979770,Melatonin affects insomnia,3636,Potential action of melatonin in insomnia.,"Is the triple ""Melatonin affects insomnia"" supported by the sentence: ""Potential action of melatonin in insomnia.""?",False, -10516034,Melatonin affects Pain,3637,"An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.","Is the triple ""Melatonin affects Pain"" supported by the sentence: ""An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.""?",False, -10432086,Melatonin affects multiple sclerosis,3638,Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.,"Is the triple ""Melatonin affects multiple sclerosis"" supported by the sentence: ""Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.""?",False, -10047665,Melatonin affects hypertensive disorder,3639,Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.,"Is the triple ""Melatonin affects hypertensive disorder"" supported by the sentence: ""Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.""?",False, -9535418,Melatonin affects injury,3640,We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.,"Is the triple ""Melatonin affects injury"" supported by the sentence: ""We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.""?",False, -9364224,Melatonin affects Pain,3641,Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.,"Is the triple ""Melatonin affects Pain"" supported by the sentence: ""Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.""?",False, -9244581,Melatonin affects migraine disorder,3642,"The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.","Is the triple ""Melatonin affects migraine disorder"" supported by the sentence: ""The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.""?",False, -9153135,Melatonin affects diabetes mellitus,3643,"Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.","Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.""?",False, -9143737,Melatonin affects epilepsy,3644,Melatonin effect on seizures in children with severe neurologic deficit disorders.,"Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Melatonin effect on seizures in children with severe neurologic deficit disorders.""?",False, -9114510,Melatonin affects ischemia reperfusion injury,3645,This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.,"Is the triple ""Melatonin affects ischemia reperfusion injury"" supported by the sentence: ""This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.""?",False, -8993003,Melatonin affects neoplasm,3646,"However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.","Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.""?",False, -8720758,Melatonin affects breast neoplasm,3647,We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.,"Is the triple ""Melatonin affects breast neoplasm"" supported by the sentence: ""We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.""?",False, -8108047,Melatonin affects depressive disorder,3648,"Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.""?",False, -7564928,Melatonin affects neoplasm,3649,Melatonin also affects tumorigenesis and tumor development.,"Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""Melatonin also affects tumorigenesis and tumor development.""?",False, -7382212,Melatonin affects brain ischemia,3650,These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.,"Is the triple ""Melatonin affects brain ischemia"" supported by the sentence: ""These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.""?",False, -26765396,Melatonin produces epilepsy,3651,Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.,"Is the triple ""Melatonin produces epilepsy"" supported by the sentence: ""Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.""?",False, -22867260,Melatonin produces diabetes mellitus,3652,"Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.","Is the triple ""Melatonin produces diabetes mellitus"" supported by the sentence: ""Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.""?",False, -18240585,Melatonin produces ulcerative colitis,3653,METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.,"Is the triple ""Melatonin produces ulcerative colitis"" supported by the sentence: ""METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.""?",False, -17207380,Melatonin produces autism spectrum disorder,3654,"Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.","Is the triple ""Melatonin produces autism spectrum disorder"" supported by the sentence: ""Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.""?",False, -17051558,Melatonin produces depressive disorder,3655,These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.,"Is the triple ""Melatonin produces depressive disorder"" supported by the sentence: ""These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.""?",False, -16192357,Melatonin produces sleep-wake disorder,3656,"The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.","Is the triple ""Melatonin produces sleep-wake disorder"" supported by the sentence: ""The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.""?",False, -13817260,Melatonin produces Parkinson disease,3657,"Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.","Is the triple ""Melatonin produces Parkinson disease"" supported by the sentence: ""Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.""?",False, -11388402,Melatonin produces neoplasm,3658,"The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.","Is the triple ""Melatonin produces neoplasm"" supported by the sentence: ""The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.""?",False, -9153153,Melatonin produces hypertensive disorder,3659,"Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.","Is the triple ""Melatonin produces hypertensive disorder"" supported by the sentence: ""Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.""?",False, -8191029,Melatonin produces breast neoplasm,3660,"The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.","Is the triple ""Melatonin produces breast neoplasm"" supported by the sentence: ""The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.""?",False, -24623673,Melatonin disrupts atrial fibrillation,3661,Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).,"Is the triple ""Melatonin disrupts atrial fibrillation"" supported by the sentence: ""Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).""?",False, -24220852,Melatonin disrupts metabolic disease,3662,"Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.","Is the triple ""Melatonin disrupts metabolic disease"" supported by the sentence: ""Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.""?",False, -22817547,Melatonin disrupts anxiety,3663,"Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.","Is the triple ""Melatonin disrupts anxiety"" supported by the sentence: ""Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.""?",False, -20966258,Melatonin disrupts Cognitive impairment,3664,"Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.","Is the triple ""Melatonin disrupts Cognitive impairment"" supported by the sentence: ""Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.""?",False, -20623050,"Melatonin disrupts attention deficit hyperactivity disorder, inattentive type",3665,Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.,"Is the triple ""Melatonin disrupts attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.""?",False, -19958338,Melatonin disrupts multiple sclerosis,3666,Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.,"Is the triple ""Melatonin disrupts multiple sclerosis"" supported by the sentence: ""Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.""?",False, -18007482,Melatonin disrupts Sepsis,3667,"Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.","Is the triple ""Melatonin disrupts Sepsis"" supported by the sentence: ""Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.""?",False, -18002672,Melatonin disrupts Pain,3668,STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.,"Is the triple ""Melatonin disrupts Pain"" supported by the sentence: ""STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.""?",False, -16753621,Melatonin disrupts sleep-wake disorder,3669,"Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.","Is the triple ""Melatonin disrupts sleep-wake disorder"" supported by the sentence: ""Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.""?",False, -14914180,Melatonin disrupts melanoma,3670,"Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.","Is the triple ""Melatonin disrupts melanoma"" supported by the sentence: ""Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.""?",False, -14617999,"Melatonin disrupts dermatitis, atopic",3671,"Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.","Is the triple ""Melatonin disrupts dermatitis, atopic"" supported by the sentence: ""Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.""?",False, -13855513,Melatonin disrupts Hemorrhage,3672,"Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.","Is the triple ""Melatonin disrupts Hemorrhage"" supported by the sentence: ""Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.""?",False, -10721769,Melatonin disrupts depressive disorder,3673,Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.,"Is the triple ""Melatonin disrupts depressive disorder"" supported by the sentence: ""Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.""?",False, -10333555,Melatonin disrupts injury,3674,"Moreover, melatonin diminished iron-induced oxidative injury.","Is the triple ""Melatonin disrupts injury"" supported by the sentence: ""Moreover, melatonin diminished iron-induced oxidative injury.""?",False, -10294227,Melatonin disrupts breast neoplasm,3675,"During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.","Is the triple ""Melatonin disrupts breast neoplasm"" supported by the sentence: ""During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.""?",False, -10070181,Melatonin disrupts brain ischemia,3676,"Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.","Is the triple ""Melatonin disrupts brain ischemia"" supported by the sentence: ""Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.""?",False, -10008170,Melatonin disrupts Marchiafava-Bignami disease,3677,"Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.","Is the triple ""Melatonin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.""?",False, -8932328,Melatonin disrupts epilepsy,3678,"Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.","Is the triple ""Melatonin disrupts epilepsy"" supported by the sentence: ""Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.""?",False, -7916082,Melatonin disrupts ischemia reperfusion injury,3679,"Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.","Is the triple ""Melatonin disrupts ischemia reperfusion injury"" supported by the sentence: ""Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.""?",False, -7545973,Melatonin disrupts neoplasm,3680,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin disrupts neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, -24902716,Melatonin prevents stomatitis,3681,"MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).","Is the triple ""Melatonin prevents stomatitis"" supported by the sentence: ""MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).""?",False, -24687342,Melatonin prevents essential hypertension,3682,The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.,"Is the triple ""Melatonin prevents essential hypertension"" supported by the sentence: ""The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.""?",False, -24623674,Melatonin prevents atrial fibrillation,3683,"Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.","Is the triple ""Melatonin prevents atrial fibrillation"" supported by the sentence: ""Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.""?",False, -24368351,Melatonin prevents acute kidney failure,3684,"Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.","Is the triple ""Melatonin prevents acute kidney failure"" supported by the sentence: ""Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.""?",False, -23824121,Melatonin prevents dementia,3685,"While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.","Is the triple ""Melatonin prevents dementia"" supported by the sentence: ""While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.""?",False, -23122960,Melatonin prevents Cognitive impairment,3686,Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.,"Is the triple ""Melatonin prevents Cognitive impairment"" supported by the sentence: ""Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.""?",False, -22817548,Melatonin prevents anxiety,3687,"Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).","Is the triple ""Melatonin prevents anxiety"" supported by the sentence: ""Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).""?",False, -21718214,Melatonin prevents sleep-wake disorder,3688,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Melatonin prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, -20260777,Melatonin prevents Pain,3689,"In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).","Is the triple ""Melatonin prevents Pain"" supported by the sentence: ""In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).""?",False, -19640170,Melatonin prevents aortic aneurysm,3690,This study examined whether melatonin has protective or therapeutic effects against AAAs.,"Is the triple ""Melatonin prevents aortic aneurysm"" supported by the sentence: ""This study examined whether melatonin has protective or therapeutic effects against AAAs.""?",False, -18396849,Melatonin prevents Sepsis,3691,Previous studies have suggested that melatonin is protective during sepsis.,"Is the triple ""Melatonin prevents Sepsis"" supported by the sentence: ""Previous studies have suggested that melatonin is protective during sepsis.""?",False, -18141997,Melatonin prevents metabolic disease,3692,Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.,"Is the triple ""Melatonin prevents metabolic disease"" supported by the sentence: ""Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.""?",False, -16995162,Melatonin prevents metabolic syndrome X,3693,Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.,"Is the triple ""Melatonin prevents metabolic syndrome X"" supported by the sentence: ""Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.""?",False, -16549748,Melatonin prevents burn,3694,Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.,"Is the triple ""Melatonin prevents burn"" supported by the sentence: ""Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.""?",False, -16245777,Melatonin prevents schizophrenia,3695,"The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.","Is the triple ""Melatonin prevents schizophrenia"" supported by the sentence: ""The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.""?",False, -16232642,Melatonin prevents Marchiafava-Bignami disease,3696,"This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.","Is the triple ""Melatonin prevents Marchiafava-Bignami disease"" supported by the sentence: ""This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.""?",False, -15150085,Melatonin prevents depressive disorder,3697,"It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.","Is the triple ""Melatonin prevents depressive disorder"" supported by the sentence: ""It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.""?",False, -14373042,Melatonin prevents Parkinson disease,3698,"We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.","Is the triple ""Melatonin prevents Parkinson disease"" supported by the sentence: ""We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.""?",False, -11616466,Melatonin prevents autism spectrum disorder,3699,CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.,"Is the triple ""Melatonin prevents autism spectrum disorder"" supported by the sentence: ""CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.""?",False, -11366467,Melatonin prevents migraine disorder,3700,"Melatonin, 3 mg, is effective for migraine prevention.","Is the triple ""Melatonin prevents migraine disorder"" supported by the sentence: ""Melatonin, 3 mg, is effective for migraine prevention.""?",False, -11108260,Melatonin prevents hypertensive disorder,3701,We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.,"Is the triple ""Melatonin prevents hypertensive disorder"" supported by the sentence: ""We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.""?",False, -11061121,Melatonin prevents insomnia,3702,Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.,"Is the triple ""Melatonin prevents insomnia"" supported by the sentence: ""Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.""?",False, -10234923,Melatonin prevents breast neoplasm,3703,Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.,"Is the triple ""Melatonin prevents breast neoplasm"" supported by the sentence: ""Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.""?",False, -10127047,Melatonin prevents myocardial infarction,3704,Protective effect of melatonin on myocardial infarction.,"Is the triple ""Melatonin prevents myocardial infarction"" supported by the sentence: ""Protective effect of melatonin on myocardial infarction.""?",False, -9561452,Melatonin prevents diabetes mellitus,3705,Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.,"Is the triple ""Melatonin prevents diabetes mellitus"" supported by the sentence: ""Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.""?",False, -9346845,Melatonin prevents delirium,3706,Two cases are presented where melatonin was used to treat and prevent postoperative delirium.,"Is the triple ""Melatonin prevents delirium"" supported by the sentence: ""Two cases are presented where melatonin was used to treat and prevent postoperative delirium.""?",False, -9336280,Melatonin prevents brain ischemia,3707,"Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.","Is the triple ""Melatonin prevents brain ischemia"" supported by the sentence: ""Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.""?",False, -8678642,Melatonin prevents epilepsy,3708,"The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.","Is the triple ""Melatonin prevents epilepsy"" supported by the sentence: ""The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.""?",False, -8166782,Melatonin prevents ischemia reperfusion injury,3709,"In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.","Is the triple ""Melatonin prevents ischemia reperfusion injury"" supported by the sentence: ""In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.""?",False, -7622774,Melatonin prevents injury,3710,CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.,"Is the triple ""Melatonin prevents injury"" supported by the sentence: ""CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.""?",False, -7545974,Melatonin prevents neoplasm,3711,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin prevents neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, -19276524,Melatonin exacerbates diabetes mellitus,3712,"However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.","Is the triple ""Melatonin exacerbates diabetes mellitus"" supported by the sentence: ""However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.""?",False, -7980097,Melatonin exacerbates brain ischemia,3713,"Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.","Is the triple ""Melatonin exacerbates brain ischemia"" supported by the sentence: ""Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.""?",False, -27283551,Melatonin predisposes hypertensive disorder,3714,"Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.","Is the triple ""Melatonin predisposes hypertensive disorder"" supported by the sentence: ""Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.""?",False, -23266236,Melatonin predisposes epilepsy,3715,"CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.","Is the triple ""Melatonin predisposes epilepsy"" supported by the sentence: ""CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.""?",False, -21026194,Melatonin predisposes migraine disorder,3716,"CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.","Is the triple ""Melatonin predisposes migraine disorder"" supported by the sentence: ""CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.""?",False, -20835242,Melatonin predisposes metabolic syndrome X,3717,"Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.","Is the triple ""Melatonin predisposes metabolic syndrome X"" supported by the sentence: ""Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.""?",False, -20419573,Melatonin predisposes major depressive disorder,3718,Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.,"Is the triple ""Melatonin predisposes major depressive disorder"" supported by the sentence: ""Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.""?",False, -19382519,Melatonin predisposes periodontal disorder,3719,"With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.","Is the triple ""Melatonin predisposes periodontal disorder"" supported by the sentence: ""With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.""?",False, -18749948,Melatonin predisposes autism spectrum disorder,3720,"This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.","Is the triple ""Melatonin predisposes autism spectrum disorder"" supported by the sentence: ""This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.""?",False, -18605458,Melatonin predisposes Neonatal sepsis,3721,OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.,"Is the triple ""Melatonin predisposes Neonatal sepsis"" supported by the sentence: ""OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.""?",False, -18359560,Melatonin predisposes depressive disorder,3722,Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).,"Is the triple ""Melatonin predisposes depressive disorder"" supported by the sentence: ""Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).""?",False, -16852096,Melatonin predisposes diabetes mellitus,3723,Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.,"Is the triple ""Melatonin predisposes diabetes mellitus"" supported by the sentence: ""Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.""?",False, -15094135,Melatonin predisposes injury,3724,"The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.","Is the triple ""Melatonin predisposes injury"" supported by the sentence: ""The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.""?",False, -14875892,Melatonin predisposes pervasive developmental disorder,3725,A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.,"Is the triple ""Melatonin predisposes pervasive developmental disorder"" supported by the sentence: ""A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.""?",False, -11794031,Melatonin predisposes neoplasm,3726,"Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.","Is the triple ""Melatonin predisposes neoplasm"" supported by the sentence: ""Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.""?",False, -11643546,Melatonin predisposes dementia,3727,Melatonin relieves the neural oxidative burden that contributes to dementias.,"Is the triple ""Melatonin predisposes dementia"" supported by the sentence: ""Melatonin relieves the neural oxidative burden that contributes to dementias.""?",False, -10915746,Melatonin predisposes sleep-wake disorder,3728,"CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.","Is the triple ""Melatonin predisposes sleep-wake disorder"" supported by the sentence: ""CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.""?",False, -10114913,Melatonin predisposes myocardial infarction,3729,These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.,"Is the triple ""Melatonin predisposes myocardial infarction"" supported by the sentence: ""These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.""?",False, -12950718,RETEPLASE related to thrombotic disease,3730,Spotlight on reteplase in thrombotic occlusive disorders.,"Is the triple ""RETEPLASE related to thrombotic disease"" supported by the sentence: ""Spotlight on reteplase in thrombotic occlusive disorders.""?",False, -7082056,RETEPLASE related to stroke disorder,3731,"Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.","Is the triple ""RETEPLASE related to stroke disorder"" supported by the sentence: ""Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.""?",False, -12026281,UROKINASE related to stroke disorder,3732,Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.,"Is the triple ""UROKINASE related to stroke disorder"" supported by the sentence: ""Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.""?",False, -11808316,UROKINASE related to empyema,3733,"Intrapleural urokinase is an effective treatment, including in empyemas without loculation.","Is the triple ""UROKINASE related to empyema"" supported by the sentence: ""Intrapleural urokinase is an effective treatment, including in empyemas without loculation.""?",False, -9909017,UROKINASE related to pleural empyema,3734,Use of urokinase in childhood pleural empyema.,"Is the triple ""UROKINASE related to pleural empyema"" supported by the sentence: ""Use of urokinase in childhood pleural empyema.""?",False, -9695495,UROKINASE related to thrombotic disease,3735,Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.,"Is the triple ""UROKINASE related to thrombotic disease"" supported by the sentence: ""Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.""?",False, -7757067,UROKINASE related to pulmonary embolism,3736,CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.,"Is the triple ""UROKINASE related to pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.""?",False, -20949144,UROKINASE causes thrombotic disease,3737,"After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.","Is the triple ""UROKINASE causes thrombotic disease"" supported by the sentence: ""After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.""?",False, -7392657,UROKINASE causes pulmonary embolism,3738,"Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.","Is the triple ""UROKINASE causes pulmonary embolism"" supported by the sentence: ""Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.""?",False, -26135964,UROKINASE affects pulmonary embolism,3739,A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.,"Is the triple ""UROKINASE affects pulmonary embolism"" supported by the sentence: ""A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.""?",False, -25781305,UROKINASE affects thrombotic disease,3740,"Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.","Is the triple ""UROKINASE affects thrombotic disease"" supported by the sentence: ""Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.""?",False, -26885635,UROKINASE disrupts thrombotic disease,3741,"In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.","Is the triple ""UROKINASE disrupts thrombotic disease"" supported by the sentence: ""In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.""?",False, -11607211,UROKINASE prevents thrombotic disease,3742,"To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.","Is the triple ""UROKINASE prevents thrombotic disease"" supported by the sentence: ""To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.""?",False, -8505599,UROKINASE prevents pulmonary embolism,3743,"CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.","Is the triple ""UROKINASE prevents pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.""?",False, -26334889,UROKINASE predisposes pulmonary embolism,3744,"Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.","Is the triple ""UROKINASE predisposes pulmonary embolism"" supported by the sentence: ""Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.""?",False, -13797160,UROKINASE predisposes thrombotic disease,3745,"Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.","Is the triple ""UROKINASE predisposes thrombotic disease"" supported by the sentence: ""Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.""?",False, -13590349,Buspirone causes depressive disorder,3746,"Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.","Is the triple ""Buspirone causes depressive disorder"" supported by the sentence: ""Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.""?",False, -7712722,Buspirone affects depressive disorder,3747,"The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.","Is the triple ""Buspirone affects depressive disorder"" supported by the sentence: ""The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.""?",False, -7425584,Buspirone affects physiological sexual disorder,3748,It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.,"Is the triple ""Buspirone affects physiological sexual disorder"" supported by the sentence: ""It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.""?",False, -19950288,Buspirone disrupts schizophrenia,3749,Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.,"Is the triple ""Buspirone disrupts schizophrenia"" supported by the sentence: ""Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.""?",False, -10992881,Buspirone disrupts anxiety,3750,"CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.","Is the triple ""Buspirone disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.""?",False, -19904227,Iodine related to thyroid tumor,3751,Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.,"Is the triple ""Iodine related to thyroid tumor"" supported by the sentence: ""Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.""?",False, -10048388,Iodine related to breast neoplasm,3752,"Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.","Is the triple ""Iodine related to breast neoplasm"" supported by the sentence: ""Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.""?",False, -10651106,Iodine causes thyroid tumor,3753,Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.,"Is the triple ""Iodine causes thyroid tumor"" supported by the sentence: ""Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.""?",False, -10745802,Iodine affects thyroid tumor,3754,Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.,"Is the triple ""Iodine affects thyroid tumor"" supported by the sentence: ""Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.""?",False, -24773674,Iodine prevents thyroid tumor,3755,These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.,"Is the triple ""Iodine prevents thyroid tumor"" supported by the sentence: ""These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.""?",False, -27167996,Iodine predisposes thyroid tumor,3756,Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.,"Is the triple ""Iodine predisposes thyroid tumor"" supported by the sentence: ""Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.""?",False, -7362584,Acetaminophen subclass of Acetaminophen sulfate,3757,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen sulfate"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, -7362582,Acetaminophen subclass of Acetaminophen glucuronide,3758,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen glucuronide"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, -26133523,Acetaminophen related to neoplasm,3759,"None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.","Is the triple ""Acetaminophen related to neoplasm"" supported by the sentence: ""None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.""?",False, -25084939,Acetaminophen related to Acetimidoquinone,3760,"Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.","Is the triple ""Acetaminophen related to Acetimidoquinone"" supported by the sentence: ""Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.""?",False, -24055705,Acetaminophen related to osteoarthritis,3761,"As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.","Is the triple ""Acetaminophen related to osteoarthritis"" supported by the sentence: ""As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.""?",False, -20371329,Acetaminophen related to digestive system disorder,3762,Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.,"Is the triple ""Acetaminophen related to digestive system disorder"" supported by the sentence: ""Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.""?",False, -19637295,Acetaminophen related to Renal Colic,3763,"METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.","Is the triple ""Acetaminophen related to Renal Colic"" supported by the sentence: ""METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.""?",False, -16009572,Acetaminophen related to rheumatoid arthritis,3764,"The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).","Is the triple ""Acetaminophen related to rheumatoid arthritis"" supported by the sentence: ""The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).""?",False, -12233599,Acetaminophen related to Acetaminophen glucuronide,3765,The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.,"Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.""?",False, -12541409,Acetaminophen related to Acetaminophen glucuronide,3766,"The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).","Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).""?",False, -15777318,Acetaminophen coexists with Acetimidoquinone,3767,"In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.","Is the triple ""Acetaminophen coexists with Acetimidoquinone"" supported by the sentence: ""In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.""?",False, -18513016,Acetaminophen derives from Acetimidoquinone,3768,"Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.","Is the triple ""Acetaminophen derives from Acetimidoquinone"" supported by the sentence: ""Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.""?",False, -16596646,Acetaminophen derives from Acetaminophen glucuronide,3769,Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.,"Is the triple ""Acetaminophen derives from Acetaminophen glucuronide"" supported by the sentence: ""Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.""?",False, -7891577,Acetaminophen physically interacts with Acetimidoquinone,3770,"Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.""?",False, -11100770,Acetaminophen physically interacts with Acetimidoquinone,3771,"All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).""?",False, -8441876,Acetaminophen physically interacts with Acetaminophen glucuronide,3772,"Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.","Is the triple ""Acetaminophen physically interacts with Acetaminophen glucuronide"" supported by the sentence: ""Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.""?",False, -25685005,Acetaminophen causes neoplasm,3773,No pathologic or statistical evidence of induction of tumors by AAP was found.,"Is the triple ""Acetaminophen causes neoplasm"" supported by the sentence: ""No pathologic or statistical evidence of induction of tumors by AAP was found.""?",False, -24327037,Acetaminophen causes anxiety,3774,"In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.","Is the triple ""Acetaminophen causes anxiety"" supported by the sentence: ""In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.""?",False, -23482103,Acetaminophen causes nervous system disorder,3775,"Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.","Is the triple ""Acetaminophen causes nervous system disorder"" supported by the sentence: ""Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.""?",False, -21920646,Acetaminophen causes type 1 diabetes mellitus,3776,"A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.","Is the triple ""Acetaminophen causes type 1 diabetes mellitus"" supported by the sentence: ""A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.""?",False, -21160030,Acetaminophen causes Postoperative Nausea and Vomiting,3777,Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.,"Is the triple ""Acetaminophen causes Postoperative Nausea and Vomiting"" supported by the sentence: ""Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.""?",False, -19409287,Acetaminophen causes myopia,3778,ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.,"Is the triple ""Acetaminophen causes myopia"" supported by the sentence: ""ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.""?",False, -17485084,Acetaminophen causes obesity disorder,3779,Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.,"Is the triple ""Acetaminophen causes obesity disorder"" supported by the sentence: ""Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.""?",False, -17093716,Acetaminophen causes kidney disorder,3780,"PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.","Is the triple ""Acetaminophen causes kidney disorder"" supported by the sentence: ""PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.""?",False, -16903597,Acetaminophen causes hypertensive disorder,3781,"Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.","Is the triple ""Acetaminophen causes hypertensive disorder"" supported by the sentence: ""Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.""?",False, -16867510,Acetaminophen causes delirium,3782,Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.,"Is the triple ""Acetaminophen causes delirium"" supported by the sentence: ""Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.""?",False, -16756158,Acetaminophen causes osteoarthritis,3783,"Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.","Is the triple ""Acetaminophen causes osteoarthritis"" supported by the sentence: ""Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.""?",False, -16155885,Acetaminophen causes Hemorrhage,3784,"CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.","Is the triple ""Acetaminophen causes Hemorrhage"" supported by the sentence: ""CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.""?",False, -15922778,Acetaminophen causes Pruritus,3785,"Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.","Is the triple ""Acetaminophen causes Pruritus"" supported by the sentence: ""Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.""?",False, -14972793,Acetaminophen causes brain injury,3786,High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.,"Is the triple ""Acetaminophen causes brain injury"" supported by the sentence: ""High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.""?",False, -12302511,Acetaminophen causes Headache,3787,"Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.","Is the triple ""Acetaminophen causes Headache"" supported by the sentence: ""Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.""?",False, -9507087,Acetaminophen causes Vomiting,3788,A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.,"Is the triple ""Acetaminophen causes Vomiting"" supported by the sentence: ""A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.""?",False, -8697178,Acetaminophen causes Pain,3789,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Pain"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, -8697177,Acetaminophen causes Fever,3790,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Fever"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, -7330301,Acetaminophen causes injury,3791,"Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.","Is the triple ""Acetaminophen causes injury"" supported by the sentence: ""Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.""?",False, -24793249,Acetaminophen affects hypertensive disorder,3792,Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.,"Is the triple ""Acetaminophen affects hypertensive disorder"" supported by the sentence: ""Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.""?",False, -23912807,Acetaminophen affects Vomiting,3793,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, -23912806,Acetaminophen affects Nausea,3794,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, -23442508,Acetaminophen affects pharyngitis,3795,"The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.","Is the triple ""Acetaminophen affects pharyngitis"" supported by the sentence: ""The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.""?",False, -23226380,Acetaminophen affects anxiety,3796,"Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.","Is the triple ""Acetaminophen affects anxiety"" supported by the sentence: ""Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.""?",False, -22849168,Acetaminophen affects neoplasm,3797,The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.,"Is the triple ""Acetaminophen affects neoplasm"" supported by the sentence: ""The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.""?",False, -22389406,Acetaminophen affects Low back pain,3798,"This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.","Is the triple ""Acetaminophen affects Low back pain"" supported by the sentence: ""This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.""?",False, -22267005,Acetaminophen affects Acute Pain,3799,"Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.","Is the triple ""Acetaminophen affects Acute Pain"" supported by the sentence: ""Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.""?",False, -21609859,Acetaminophen affects migraine disorder,3800,The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.,"Is the triple ""Acetaminophen affects migraine disorder"" supported by the sentence: ""The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.""?",False, -21375424,Acetaminophen affects preeclampsia,3801,"Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.","Is the triple ""Acetaminophen affects preeclampsia"" supported by the sentence: ""Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.""?",False, -21166764,Acetaminophen affects Parkinson disease,3802,"Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.","Is the triple ""Acetaminophen affects Parkinson disease"" supported by the sentence: ""Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.""?",False, -20477729,Acetaminophen affects Hemorrhage,3803,"RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).","Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).""?",False, -20447454,Acetaminophen affects rheumatoid arthritis,3804,"Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.","Is the triple ""Acetaminophen affects rheumatoid arthritis"" supported by the sentence: ""Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.""?",False, -19937801,Acetaminophen affects Pain,3805,Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.,"Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.""?",False, -19285056,Acetaminophen affects Renal Colic,3806,"BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.","Is the triple ""Acetaminophen affects Renal Colic"" supported by the sentence: ""BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.""?",False, -18899993,Acetaminophen affects Abdominal pain,3807,Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).,"Is the triple ""Acetaminophen affects Abdominal pain"" supported by the sentence: ""Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).""?",False, -18709599,Acetaminophen affects Acetimidoquinone,3808,The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.,"Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.""?",False, -18394888,Acetaminophen affects Headache,3809,"She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.","Is the triple ""Acetaminophen affects Headache"" supported by the sentence: ""She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.""?",False, -18298999,Acetaminophen affects patent ductus arteriosus,3810,Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.,"Is the triple ""Acetaminophen affects patent ductus arteriosus"" supported by the sentence: ""Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.""?",False, -16707575,Acetaminophen affects obesity disorder,3811,"The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.","Is the triple ""Acetaminophen affects obesity disorder"" supported by the sentence: ""The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.""?",False, -16662805,Acetaminophen affects Vomiting,3812,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, -16662804,Acetaminophen affects Nausea,3813,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, -15922777,Acetaminophen affects Pruritus,3814,Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.,"Is the triple ""Acetaminophen affects Pruritus"" supported by the sentence: ""Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.""?",False, -15909356,Acetaminophen affects Postoperative Nausea and Vomiting,3815,OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.,"Is the triple ""Acetaminophen affects Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.""?",False, -12673406,Acetaminophen affects bone fracture,3816,"For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).","Is the triple ""Acetaminophen affects bone fracture"" supported by the sentence: ""For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).""?",False, -12488756,Acetaminophen affects Acetaminophen glucuronide,3817,"The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.""?",False, -11625632,Acetaminophen affects Chronic pain,3818,The role of paracetamol in chronic pain: an evidence-based approach.,"Is the triple ""Acetaminophen affects Chronic pain"" supported by the sentence: ""The role of paracetamol in chronic pain: an evidence-based approach.""?",False, -11439823,Acetaminophen affects type 1 diabetes mellitus,3819,"The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.","Is the triple ""Acetaminophen affects type 1 diabetes mellitus"" supported by the sentence: ""The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.""?",False, -11319146,Acetaminophen affects neuralgia,3820,The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.,"Is the triple ""Acetaminophen affects neuralgia"" supported by the sentence: ""The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.""?",False, -11289717,Acetaminophen affects osteoarthritis,3821,"Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.","Is the triple ""Acetaminophen affects osteoarthritis"" supported by the sentence: ""Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.""?",False, -11227783,Acetaminophen affects Fever,3822,Young age and high fever were associated with significantly higher acetaminophen levels.,"Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Young age and high fever were associated with significantly higher acetaminophen levels.""?",False, -11159989,Acetaminophen affects Hemorrhage,3823,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?",False, -10410536,Acetaminophen affects injury,3824,Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).,"Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).""?",False, -10195419,Acetaminophen affects Pain,3825,"The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.","Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.""?",False, -9259287,Acetaminophen affects Fever,3826,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, -8642669,Acetaminophen affects Hemorrhage,3827,CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.""?",False, -8097597,Acetaminophen affects injury,3828,"These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.","Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.""?",False, -25639149,Acetaminophen affects Acetaminophen glucuronide,3829,"Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.""?",False, -20782169,Acetaminophen affects Acetimidoquinone,3830,"Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.","Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.""?",False, -25481457,Acetaminophen disrupts patent ductus arteriosus,3831,"Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.","Is the triple ""Acetaminophen disrupts patent ductus arteriosus"" supported by the sentence: ""Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.""?",False, -25355292,Acetaminophen disrupts delirium,3832,"Individually, acetaminophen was associated with reduced delirium.","Is the triple ""Acetaminophen disrupts delirium"" supported by the sentence: ""Individually, acetaminophen was associated with reduced delirium.""?",False, -19614622,Acetaminophen disrupts Headache,3833,The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.,"Is the triple ""Acetaminophen disrupts Headache"" supported by the sentence: ""The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.""?",False, -16273113,Acetaminophen disrupts Fever,3834,"Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.","Is the triple ""Acetaminophen disrupts Fever"" supported by the sentence: ""Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.""?",False, -12102031,Acetaminophen disrupts Pain,3835,Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.,"Is the triple ""Acetaminophen disrupts Pain"" supported by the sentence: ""Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.""?",False, -7794905,Acetaminophen disrupts influenza,3836,"Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.","Is the triple ""Acetaminophen disrupts influenza"" supported by the sentence: ""Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.""?",False, -7640332,Acetaminophen disrupts injury,3837,"RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).","Is the triple ""Acetaminophen disrupts injury"" supported by the sentence: ""RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).""?",False, -26559635,Acetaminophen prevents malaria,3838,Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.,"Is the triple ""Acetaminophen prevents malaria"" supported by the sentence: ""Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.""?",False, -22159381,Acetaminophen prevents Hemorrhage,3839,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.","Is the triple ""Acetaminophen prevents Hemorrhage"" supported by the sentence: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?",False, -22123298,Acetaminophen prevents Fever,3840,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,"Is the triple ""Acetaminophen prevents Fever"" supported by the sentence: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?",False, -20154151,Acetaminophen prevents neuralgia,3841,"Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.","Is the triple ""Acetaminophen prevents neuralgia"" supported by the sentence: ""Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.""?",False, -20107193,Acetaminophen prevents delirium,3842,The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.,"Is the triple ""Acetaminophen prevents delirium"" supported by the sentence: ""The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.""?",False, -19168014,Acetaminophen prevents obesity disorder,3843,AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.,"Is the triple ""Acetaminophen prevents obesity disorder"" supported by the sentence: ""AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.""?",False, -19006111,Acetaminophen prevents patent ductus arteriosus,3844,Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.,"Is the triple ""Acetaminophen prevents patent ductus arteriosus"" supported by the sentence: ""Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.""?",False, -18131378,Acetaminophen prevents Low back pain,3845,CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.,"Is the triple ""Acetaminophen prevents Low back pain"" supported by the sentence: ""CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.""?",False, -18033682,Acetaminophen prevents Vomiting,3846,"Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).","Is the triple ""Acetaminophen prevents Vomiting"" supported by the sentence: ""Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).""?",False, -16975983,Acetaminophen prevents neoplasm,3847,Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.,"Is the triple ""Acetaminophen prevents neoplasm"" supported by the sentence: ""Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.""?",False, -16828191,Acetaminophen prevents rheumatoid arthritis,3848,"RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.","Is the triple ""Acetaminophen prevents rheumatoid arthritis"" supported by the sentence: ""RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.""?",False, -16784082,Acetaminophen prevents injury,3849,Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.,"Is the triple ""Acetaminophen prevents injury"" supported by the sentence: ""Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.""?",False, -16782348,Acetaminophen prevents Nausea,3850,"When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).","Is the triple ""Acetaminophen prevents Nausea"" supported by the sentence: ""When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).""?",False, -15909357,Acetaminophen prevents Postoperative Nausea and Vomiting,3851,CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.,"Is the triple ""Acetaminophen prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.""?",False, -15525446,Acetaminophen prevents Acute Pain,3852,Review: acetaminophen reduces acute migraine pain in adults.,"Is the triple ""Acetaminophen prevents Acute Pain"" supported by the sentence: ""Review: acetaminophen reduces acute migraine pain in adults.""?",False, -15467414,Acetaminophen prevents influenza,3853,METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.,"Is the triple ""Acetaminophen prevents influenza"" supported by the sentence: ""METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.""?",False, -14660734,Acetaminophen prevents cardiac rhythm disease,3854,"This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.","Is the triple ""Acetaminophen prevents cardiac rhythm disease"" supported by the sentence: ""This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.""?",False, -14372292,Acetaminophen prevents Headache,3855,"Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.","Is the triple ""Acetaminophen prevents Headache"" supported by the sentence: ""Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.""?",False, -13804263,Acetaminophen prevents type 2 diabetes mellitus,3856,"We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.","Is the triple ""Acetaminophen prevents type 2 diabetes mellitus"" supported by the sentence: ""We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.""?",False, -8695490,Acetaminophen prevents Pain,3857,"Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.","Is the triple ""Acetaminophen prevents Pain"" supported by the sentence: ""Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.""?",False, -25567880,Acetaminophen predisposes Sepsis,3858,Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?,"Is the triple ""Acetaminophen predisposes Sepsis"" supported by the sentence: ""Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?""?",False, -24917204,Acetaminophen predisposes type 2 diabetes mellitus,3859,"CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.","Is the triple ""Acetaminophen predisposes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.""?",False, -22230555,Acetaminophen predisposes delirium,3860,"Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.","Is the triple ""Acetaminophen predisposes delirium"" supported by the sentence: ""Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.""?",False, -21723139,Acetaminophen predisposes Hemorrhage,3861,"Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.","Is the triple ""Acetaminophen predisposes Hemorrhage"" supported by the sentence: ""Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.""?",False, -20594449,Acetaminophen predisposes neoplasm,3862,"The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Acetaminophen predisposes neoplasm"" supported by the sentence: ""The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).""?",False, -19914508,Acetaminophen predisposes Pain,3863,"Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.","Is the triple ""Acetaminophen predisposes Pain"" supported by the sentence: ""Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.""?",False, -16209480,Acetaminophen predisposes kidney disorder,3864,Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).,"Is the triple ""Acetaminophen predisposes kidney disorder"" supported by the sentence: ""Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).""?",False, -13597848,Acetaminophen predisposes injury,3865,"After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.","Is the triple ""Acetaminophen predisposes injury"" supported by the sentence: ""After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.""?",False, -13536066,Acetaminophen predisposes non-small cell lung carcinoma,3866,"METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.","Is the triple ""Acetaminophen predisposes non-small cell lung carcinoma"" supported by the sentence: ""METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.""?",False, -12673403,Acetaminophen predisposes bone fracture,3867,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Acetaminophen predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, -12109634,Acetaminophen predisposes Parkinson disease,3868,"No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.","Is the triple ""Acetaminophen predisposes Parkinson disease"" supported by the sentence: ""No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.""?",False, -11873681,Acetaminophen predisposes non-Hodgkin lymphoma,3869,"Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.","Is the triple ""Acetaminophen predisposes non-Hodgkin lymphoma"" supported by the sentence: ""Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.""?",False, -9834508,Acetaminophen predisposes hypertensive disorder,3870,"CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.","Is the triple ""Acetaminophen predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.""?",False, -8862839,Acetaminophen predisposes streptococcal infection,3871,Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.,"Is the triple ""Acetaminophen predisposes streptococcal infection"" supported by the sentence: ""Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.""?",False, -10289439,Chlorthalidone related to hypertensive disorder,3872,Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.,"Is the triple ""Chlorthalidone related to hypertensive disorder"" supported by the sentence: ""Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.""?",False, -10185607,Chlorthalidone related to coronary artery disorder,3873,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to coronary artery disorder"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, -10185606,Chlorthalidone related to myocardial infarction,3874,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to myocardial infarction"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, -7839079,Chlorthalidone related to essential hypertension,3875,Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.,"Is the triple ""Chlorthalidone related to essential hypertension"" supported by the sentence: ""Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.""?",False, -21616164,Chlorthalidone affects myocardial infarction,3876,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects myocardial infarction"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, -21616163,Chlorthalidone affects coronary artery disorder,3877,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects coronary artery disorder"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, -16399514,Chlorthalidone affects essential hypertension,3878,"In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.","Is the triple ""Chlorthalidone affects essential hypertension"" supported by the sentence: ""In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.""?",False, -16281975,Chlorthalidone affects hypertensive disorder,3879,"In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.","Is the triple ""Chlorthalidone affects hypertensive disorder"" supported by the sentence: ""In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.""?",False, -11587035,Chlorthalidone affects diabetes mellitus,3880,Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.,"Is the triple ""Chlorthalidone affects diabetes mellitus"" supported by the sentence: ""Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.""?",False, -11095498,Chlorthalidone prevents myocardial infarction,3881,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents myocardial infarction"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, -11095497,Chlorthalidone prevents coronary artery disorder,3882,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents coronary artery disorder"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, -8853238,Chlorthalidone prevents myocardial ischemia,3883,"CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.","Is the triple ""Chlorthalidone prevents myocardial ischemia"" supported by the sentence: ""CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.""?",False, -8036244,Chlorthalidone prevents hypertensive disorder,3884,"Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.","Is the triple ""Chlorthalidone prevents hypertensive disorder"" supported by the sentence: ""Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.""?",False, -11078982,Chlorthalidone predisposes coronary artery disorder,3885,"The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.","Is the triple ""Chlorthalidone predisposes coronary artery disorder"" supported by the sentence: ""The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.""?",False, -19123757,Propacetamol causes Pain,3886,"In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.","Is the triple ""Propacetamol causes Pain"" supported by the sentence: ""In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.""?",False, -11402898,Propacetamol prevents Pain,3887,BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.,"Is the triple ""Propacetamol prevents Pain"" supported by the sentence: ""BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.""?",False, -25540651,Isopropyl Alcohol affects Nausea,3888,"CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.","Is the triple ""Isopropyl Alcohol affects Nausea"" supported by the sentence: ""CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.""?",False, -18311094,Isopropyl Alcohol affects infectious disease,3889,CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.,"Is the triple ""Isopropyl Alcohol affects infectious disease"" supported by the sentence: ""CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.""?",False, -10697335,Isopropyl Alcohol affects burn,3890,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Isopropyl Alcohol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, -9427033,Isopropyl Alcohol prevents infectious disease,3891,"The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.","Is the triple ""Isopropyl Alcohol prevents infectious disease"" supported by the sentence: ""The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.""?",False, -21320482,Ethanol related to substance-related disorder,3892,"METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).","Is the triple ""Ethanol related to substance-related disorder"" supported by the sentence: ""METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).""?",False, -15908919,Ethanol related to hypertensive disorder,3893,"Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.","Is the triple ""Ethanol related to hypertensive disorder"" supported by the sentence: ""Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.""?",False, -14538852,Ethanol related to atrial fibrillation,3894,CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.,"Is the triple ""Ethanol related to atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.""?",False, -13852361,Ethanol related to obesity disorder,3895,"Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.","Is the triple ""Ethanol related to obesity disorder"" supported by the sentence: ""Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.""?",False, -27116018,Ethanol causes neutropenia,3896,"EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.","Is the triple ""Ethanol causes neutropenia"" supported by the sentence: ""EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.""?",False, -26520376,Ethanol causes essential hypertension,3897,"Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.","Is the triple ""Ethanol causes essential hypertension"" supported by the sentence: ""Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.""?",False, -17336935,Ethanol causes Tremor,3898,"We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.","Is the triple ""Ethanol causes Tremor"" supported by the sentence: ""We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.""?",False, -15073107,Ethanol causes alcohol-related disorders,3899,"CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.","Is the triple ""Ethanol causes alcohol-related disorders"" supported by the sentence: ""CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.""?",False, -14779551,Ethanol causes burn,3900,CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.,"Is the triple ""Ethanol causes burn"" supported by the sentence: ""CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.""?",False, -12227250,Ethanol causes bacterial infectious disease with sepsis,3901,Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.,"Is the triple ""Ethanol causes bacterial infectious disease with sepsis"" supported by the sentence: ""Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.""?",False, -11665347,Ethanol causes erectile dysfunction,3902,"Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.","Is the triple ""Ethanol causes erectile dysfunction"" supported by the sentence: ""Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.""?",False, -11096896,Ethanol causes type 2 diabetes mellitus,3903,"Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.","Is the triple ""Ethanol causes type 2 diabetes mellitus"" supported by the sentence: ""Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.""?",False, -10962858,Ethanol causes atrial fibrillation,3904,This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.,"Is the triple ""Ethanol causes atrial fibrillation"" supported by the sentence: ""This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.""?",False, -9159992,Ethanol causes obesity disorder,3905,"In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.","Is the triple ""Ethanol causes obesity disorder"" supported by the sentence: ""In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.""?",False, -8743651,Ethanol causes alcohol abuse,3906,"Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.","Is the triple ""Ethanol causes alcohol abuse"" supported by the sentence: ""Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.""?",False, -8636726,Ethanol causes major depressive disorder,3907,"For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.","Is the triple ""Ethanol causes major depressive disorder"" supported by the sentence: ""For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.""?",False, -8268450,Ethanol causes atopic eczema,3908,Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.,"Is the triple ""Ethanol causes atopic eczema"" supported by the sentence: ""Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.""?",False, -7771647,Ethanol causes hypertensive disorder,3909,High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.,"Is the triple ""Ethanol causes hypertensive disorder"" supported by the sentence: ""High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.""?",False, -7460012,Ethanol causes cirrhosis of liver,3910,[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].,"Is the triple ""Ethanol causes cirrhosis of liver"" supported by the sentence: ""[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].""?",False, -27580478,Ethanol affects cirrhosis of liver,3911,CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.,"Is the triple ""Ethanol affects cirrhosis of liver"" supported by the sentence: ""CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.""?",False, -27514790,Ethanol affects Thyroid nodule,3912,"In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.","Is the triple ""Ethanol affects Thyroid nodule"" supported by the sentence: ""In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.""?",False, -26762447,Ethanol affects neutropenia,3913,"To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).","Is the triple ""Ethanol affects neutropenia"" supported by the sentence: ""To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).""?",False, -23912654,Ethanol affects atrial fibrillation,3914,"Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.""?",False, -23763968,Ethanol affects substance-related disorder,3915,"CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.","Is the triple ""Ethanol affects substance-related disorder"" supported by the sentence: ""CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.""?",False, -19533165,Ethanol affects hypertensive disorder,3916,"As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.","Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.""?",False, -19155713,Ethanol affects cannabis dependence,3917,"Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.","Is the triple ""Ethanol affects cannabis dependence"" supported by the sentence: ""Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.""?",False, -16819917,Ethanol affects Chronic pain,3918,"INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.""?",False, -15671844,Ethanol affects obesity disorder,3919,"The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.""?",False, -14737169,Ethanol affects Chronic pain,3920,"Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.""?",False, -14527564,Ethanol affects benign prostatic hyperplasia,3921,Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.,"Is the triple ""Ethanol affects benign prostatic hyperplasia"" supported by the sentence: ""Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.""?",False, -13226372,Ethanol affects atrial fibrillation,3922,"BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.""?",False, -12698965,Ethanol affects major depressive disorder,3923,"An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.""?",False, -12166837,Ethanol affects type 2 diabetes mellitus,3924,Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.""?",False, -10697334,Ethanol affects burn,3925,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, -9822489,Ethanol affects Tremor,3926,"Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.""?",False, -9174558,Ethanol affects Tremor,3927,"The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.""?",False, -9116052,Ethanol affects major depressive disorder,3928,"RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.""?",False, -8931619,Ethanol affects hypertensive disorder,3929,The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.,"Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.""?",False, -8730041,Ethanol affects burn,3930,"Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.""?",False, -8616967,Ethanol affects type 2 diabetes mellitus,3931,CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.""?",False, -8569555,Ethanol affects alcohol abuse,3932,"This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.""?",False, -8363507,Ethanol affects obesity disorder,3933,"Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.""?",False, -7210977,Ethanol affects alcohol abuse,3934,"CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.""?",False, -25366419,Ethanol disrupts ventricular tachycardia,3935,"However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.","Is the triple ""Ethanol disrupts ventricular tachycardia"" supported by the sentence: ""However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.""?",False, -24747388,Ethanol disrupts obesity disorder,3936,"In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.","Is the triple ""Ethanol disrupts obesity disorder"" supported by the sentence: ""In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.""?",False, -22793590,Ethanol disrupts Infection,3937,"In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.","Is the triple ""Ethanol disrupts Infection"" supported by the sentence: ""In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.""?",False, -20664067,Ethanol disrupts Chronic pain,3938,"Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).","Is the triple ""Ethanol disrupts Chronic pain"" supported by the sentence: ""Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).""?",False, -19084276,Ethanol disrupts hypertensive disorder,3939,"Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.","Is the triple ""Ethanol disrupts hypertensive disorder"" supported by the sentence: ""Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.""?",False, -15586620,Ethanol disrupts Tremor,3940,Temporary suppression of the tremor by alcohol is seen in about one-third of cases.,"Is the triple ""Ethanol disrupts Tremor"" supported by the sentence: ""Temporary suppression of the tremor by alcohol is seen in about one-third of cases.""?",False, -15580442,Ethanol disrupts atrial fibrillation,3941,"In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).","Is the triple ""Ethanol disrupts atrial fibrillation"" supported by the sentence: ""In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).""?",False, -12535146,Ethanol disrupts type 2 diabetes mellitus,3942,Alcohol from wine was associated with reduced risk of Type 2 diabetes.,"Is the triple ""Ethanol disrupts type 2 diabetes mellitus"" supported by the sentence: ""Alcohol from wine was associated with reduced risk of Type 2 diabetes.""?",False, -9920913,Ethanol disrupts constipation disorder,3943,"Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).","Is the triple ""Ethanol disrupts constipation disorder"" supported by the sentence: ""Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).""?",False, -27717904,Ethanol prevents cirrhosis of liver,3944,HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.,"Is the triple ""Ethanol prevents cirrhosis of liver"" supported by the sentence: ""HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.""?",False, -22976273,Ethanol prevents Infection,3945,Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.,"Is the triple ""Ethanol prevents Infection"" supported by the sentence: ""Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.""?",False, -21338360,Ethanol prevents atrial fibrillation,3946,Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.,"Is the triple ""Ethanol prevents atrial fibrillation"" supported by the sentence: ""Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.""?",False, -20664068,Ethanol prevents Chronic pain,3947,An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.,"Is the triple ""Ethanol prevents Chronic pain"" supported by the sentence: ""An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.""?",False, -14465260,Ethanol prevents bacterial infectious disease with sepsis,3948,Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.,"Is the triple ""Ethanol prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.""?",False, -13158318,Ethanol prevents erectile dysfunction,3949,More research is needed to confirm whether alcohol is protective or is unrelated to ED development.,"Is the triple ""Ethanol prevents erectile dysfunction"" supported by the sentence: ""More research is needed to confirm whether alcohol is protective or is unrelated to ED development.""?",False, -12078103,Ethanol prevents alcohol abuse,3950,"Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.","Is the triple ""Ethanol prevents alcohol abuse"" supported by the sentence: ""Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.""?",False, -11890775,Ethanol prevents type 2 diabetes mellitus,3951,Alcohol for the prevention of type 2 diabetes mellitus?,"Is the triple ""Ethanol prevents type 2 diabetes mellitus"" supported by the sentence: ""Alcohol for the prevention of type 2 diabetes mellitus?""?",False, -11547578,Ethanol prevents Tremor,3952,"Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.","Is the triple ""Ethanol prevents Tremor"" supported by the sentence: ""Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.""?",False, -10032139,Ethanol prevents obesity disorder,3953,"During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.","Is the triple ""Ethanol prevents obesity disorder"" supported by the sentence: ""During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.""?",False, -8207881,Ethanol prevents hypertensive disorder,3954,Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.,"Is the triple ""Ethanol prevents hypertensive disorder"" supported by the sentence: ""Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.""?",False, -26228661,Ethanol predisposes essential hypertension,3955,"Alcohol, personality and predisposition to essential hypertension.","Is the triple ""Ethanol predisposes essential hypertension"" supported by the sentence: ""Alcohol, personality and predisposition to essential hypertension.""?",False, -23006394,Ethanol predisposes constipation disorder,3956,"The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.","Is the triple ""Ethanol predisposes constipation disorder"" supported by the sentence: ""The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.""?",False, -21458894,Ethanol predisposes burn,3957,The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.,"Is the triple ""Ethanol predisposes burn"" supported by the sentence: ""The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.""?",False, -21015200,Ethanol predisposes benign prostatic hyperplasia,3958,The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.,"Is the triple ""Ethanol predisposes benign prostatic hyperplasia"" supported by the sentence: ""The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.""?",False, -20014749,Ethanol predisposes neuroblastoma,3959,"STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.","Is the triple ""Ethanol predisposes neuroblastoma"" supported by the sentence: ""STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.""?",False, -19550164,Ethanol predisposes endometriosis,3960,"Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.","Is the triple ""Ethanol predisposes endometriosis"" supported by the sentence: ""Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.""?",False, -15239058,Ethanol predisposes cannabis dependence,3961,"Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.","Is the triple ""Ethanol predisposes cannabis dependence"" supported by the sentence: ""Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.""?",False, -13742110,Ethanol predisposes cirrhosis of liver,3962,"It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.","Is the triple ""Ethanol predisposes cirrhosis of liver"" supported by the sentence: ""It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.""?",False, -13158317,Ethanol predisposes erectile dysfunction,3963,"Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.","Is the triple ""Ethanol predisposes erectile dysfunction"" supported by the sentence: ""Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.""?",False, -11801709,Ethanol predisposes type 2 diabetes mellitus,3964,No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.,"Is the triple ""Ethanol predisposes type 2 diabetes mellitus"" supported by the sentence: ""No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.""?",False, -11652545,Ethanol predisposes obesity disorder,3965,Alcohol could contribute to obesity.,"Is the triple ""Ethanol predisposes obesity disorder"" supported by the sentence: ""Alcohol could contribute to obesity.""?",False, -11461204,Ethanol predisposes atrial fibrillation,3966,"In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.","Is the triple ""Ethanol predisposes atrial fibrillation"" supported by the sentence: ""In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.""?",False, -9864711,Ethanol predisposes major depressive disorder,3967,"Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.","Is the triple ""Ethanol predisposes major depressive disorder"" supported by the sentence: ""Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.""?",False, -9226083,Ethanol predisposes alcohol abuse,3968,BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.,"Is the triple ""Ethanol predisposes alcohol abuse"" supported by the sentence: ""BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.""?",False, -8895200,Ethanol predisposes hypertensive disorder,3969,The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.,"Is the triple ""Ethanol predisposes hypertensive disorder"" supported by the sentence: ""The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.""?",False, -22402878,Sodium Hypochlorite related to Infection,3970,Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.,"Is the triple ""Sodium Hypochlorite related to Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.""?",False, -22402879,Sodium Hypochlorite prevents Infection,3971,"Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.","Is the triple ""Sodium Hypochlorite prevents Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.""?",False, -22325598,Sodium Hypochlorite prevents Pain,3972,"Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.","Is the triple ""Sodium Hypochlorite prevents Pain"" supported by the sentence: ""Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.""?",False, -23522159,Hydrogen Peroxide related to gingivitis,3973,"Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.","Is the triple ""Hydrogen Peroxide related to gingivitis"" supported by the sentence: ""Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.""?",False, -10185817,Hydrogen Peroxide related to acne,3974,STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.,"Is the triple ""Hydrogen Peroxide related to acne"" supported by the sentence: ""STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.""?",False, -9091124,Hydrogen Peroxide related to injury,3975,Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.,"Is the triple ""Hydrogen Peroxide related to injury"" supported by the sentence: ""Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.""?",False, -21979927,Hydrogen Peroxide causes seborrheic keratosis,3976,Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.,"Is the triple ""Hydrogen Peroxide causes seborrheic keratosis"" supported by the sentence: ""Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.""?",False, -7121153,Hydrogen Peroxide causes injury,3977,Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.,"Is the triple ""Hydrogen Peroxide causes injury"" supported by the sentence: ""Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.""?",False, -18988282,Hydrogen Peroxide affects severe acute respiratory syndrome,3978,"Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.","Is the triple ""Hydrogen Peroxide affects severe acute respiratory syndrome"" supported by the sentence: ""Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.""?",False, -15261236,Hydrogen Peroxide affects gingivitis,3979,"Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.","Is the triple ""Hydrogen Peroxide affects gingivitis"" supported by the sentence: ""Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.""?",False, -9489971,Hydrogen Peroxide affects injury,3980,Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.""?",False, -7188934,Hydrogen Peroxide affects injury,3981,These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.""?",False, -20490056,Hydrogen Peroxide disrupts dental caries,3982,"Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.","Is the triple ""Hydrogen Peroxide disrupts dental caries"" supported by the sentence: ""Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.""?",False, -17081431,Hydrogen Peroxide disrupts injury,3983,Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.,"Is the triple ""Hydrogen Peroxide disrupts injury"" supported by the sentence: ""Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.""?",False, -8804977,Hydrogen Peroxide disrupts gingivitis,3984,CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.,"Is the triple ""Hydrogen Peroxide disrupts gingivitis"" supported by the sentence: ""CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.""?",False, -21124110,Hydrogen Peroxide prevents acne,3985,"Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.","Is the triple ""Hydrogen Peroxide prevents acne"" supported by the sentence: ""Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.""?",False, -11091070,Hydrogen Peroxide prevents gingivitis,3986,CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.,"Is the triple ""Hydrogen Peroxide prevents gingivitis"" supported by the sentence: ""CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.""?",False, -7482647,Hydrogen Peroxide prevents injury,3987,"Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.","Is the triple ""Hydrogen Peroxide prevents injury"" supported by the sentence: ""Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.""?",False, -19925807,Hydrogen Peroxide predisposes dental caries,3988,"Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.","Is the triple ""Hydrogen Peroxide predisposes dental caries"" supported by the sentence: ""Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.""?",False, -10852631,Hydrogen Peroxide predisposes injury,3989,Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.,"Is the triple ""Hydrogen Peroxide predisposes injury"" supported by the sentence: ""Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.""?",False, -23181733,Vitamin K1 related to Hemorrhage,3990,"Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).","Is the triple ""Vitamin K1 related to Hemorrhage"" supported by the sentence: ""Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).""?",False, -20221966,Vitamin K1 related to postmenopausal osteoporosis,3991,Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.,"Is the triple ""Vitamin K1 related to postmenopausal osteoporosis"" supported by the sentence: ""Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.""?",False, -19764095,Vitamin K1 related to osteoporosis,3992,Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.,"Is the triple ""Vitamin K1 related to osteoporosis"" supported by the sentence: ""Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.""?",False, -17682094,Vitamin K1 related to atrial fibrillation,3993,We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.,"Is the triple ""Vitamin K1 related to atrial fibrillation"" supported by the sentence: ""We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.""?",False, -13777524,Vitamin K1 related to cystic fibrosis,3994,Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.,"Is the triple ""Vitamin K1 related to cystic fibrosis"" supported by the sentence: ""Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.""?",False, -11304774,Vitamin K1 affects Hemorrhage,3995,"RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.","Is the triple ""Vitamin K1 affects Hemorrhage"" supported by the sentence: ""RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.""?",False, -24408540,Vitamin K1 prevents Hemorrhage,3996,OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.,"Is the triple ""Vitamin K1 prevents Hemorrhage"" supported by the sentence: ""OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.""?",False, -13476259,Vitamin K1 prevents vitamin K deficiency hemorrhagic disease,3997,OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.,"Is the triple ""Vitamin K1 prevents vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.""?",False, -10772424,Vitamin K1 predisposes postmenopausal osteoporosis,3998,"If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.","Is the triple ""Vitamin K1 predisposes postmenopausal osteoporosis"" supported by the sentence: ""If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.""?",False, -9319754,Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease,3999,"Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.","Is the triple ""Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.""?",False, -24430542,Indapamide causes type 2 diabetes mellitus,4000,The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).,"Is the triple ""Indapamide causes type 2 diabetes mellitus"" supported by the sentence: ""The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).""?",False, -24430545,Indapamide affects type 2 diabetes mellitus,4001,"INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.","Is the triple ""Indapamide affects type 2 diabetes mellitus"" supported by the sentence: ""INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.""?",False, -10214767,Indapamide affects hypertensive disorder,4002,This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.,"Is the triple ""Indapamide affects hypertensive disorder"" supported by the sentence: ""This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.""?",False, -13327254,Indapamide prevents hypertensive disorder,4003,During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.,"Is the triple ""Indapamide prevents hypertensive disorder"" supported by the sentence: ""During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.""?",False, -18173402,Perphenazine related to schizophrenia,4004,Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.,"Is the triple ""Perphenazine related to schizophrenia"" supported by the sentence: ""Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.""?",False, -11307427,Perphenazine related to Postoperative Nausea and Vomiting,4005,"CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.","Is the triple ""Perphenazine related to Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.""?",False, -19924977,Perphenazine disrupts cocaine dependence,4006,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts cocaine dependence"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, -19924976,Perphenazine disrupts schizophrenia,4007,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts schizophrenia"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, -15171439,Perphenazine prevents Postoperative Nausea and Vomiting,4008,CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.,"Is the triple ""Perphenazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.""?",False, -27208453,Perphenazine exacerbates dementia,4009,We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.,"Is the triple ""Perphenazine exacerbates dementia"" supported by the sentence: ""We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.""?",False, -26847530,Fluphenazine affects psychotic disorder,4010,BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.,"Is the triple ""Fluphenazine affects psychotic disorder"" supported by the sentence: ""BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.""?",False, -11127872,Fluphenazine prevents psychotic disorder,4011,"Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.","Is the triple ""Fluphenazine prevents psychotic disorder"" supported by the sentence: ""Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.""?",False, -10396371,Prochlorperazine disrupts Nausea,4012,"A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.","Is the triple ""Prochlorperazine disrupts Nausea"" supported by the sentence: ""A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.""?",False, -11808182,Prochlorperazine prevents Postoperative Nausea and Vomiting,4013,"OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.","Is the triple ""Prochlorperazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.""?",False, -10634177,Prochlorperazine prevents migraine disorder,4014,Prevention of migraine in children by prochlorperazine.,"Is the triple ""Prochlorperazine prevents migraine disorder"" supported by the sentence: ""Prevention of migraine in children by prochlorperazine.""?",False, -7427448,Prochlorperazine prevents Nausea,4015,Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.,"Is the triple ""Prochlorperazine prevents Nausea"" supported by the sentence: ""Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.""?",False, -11272109,ELOSULFASE ALFA related to mucopolysaccharidosis type 4,4016,N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.,"Is the triple ""ELOSULFASE ALFA related to mucopolysaccharidosis type 4"" supported by the sentence: ""N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.""?",False, -26291786,ELOSULFASE ALFA derives from Keratan,4017,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, -26291786,ELOSULFASE ALFA derives from Keratan,4018,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, -16241796,ELOSULFASE ALFA physically interacts with Keratan,4019,"The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA physically interacts with Keratan"" supported by the sentence: ""The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, -16652816,ELOSULFASE ALFA causes mucopolysaccharidosis type 4,4020,PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.,"Is the triple ""ELOSULFASE ALFA causes mucopolysaccharidosis type 4"" supported by the sentence: ""PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.""?",False, -13130107,ELOSULFASE ALFA affects Keratan,4021,"Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA affects Keratan"" supported by the sentence: ""Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, -21593588,Pegvaliase related to phenylketonuria,4022,Case-control study about the acceptance of Pegvaliase in Phenylketonuria.,"Is the triple ""Pegvaliase related to phenylketonuria"" supported by the sentence: ""Case-control study about the acceptance of Pegvaliase in Phenylketonuria.""?",False, -23111774,Labetalol related to preeclampsia,4023,"To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.","Is the triple ""Labetalol related to preeclampsia"" supported by the sentence: ""To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.""?",False, -19865755,Labetalol related to hypertensive disorder,4024,"Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.","Is the triple ""Labetalol related to hypertensive disorder"" supported by the sentence: ""Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.""?",False, -19886747,Labetalol causes hypertensive disorder,4025,Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.,"Is the triple ""Labetalol causes hypertensive disorder"" supported by the sentence: ""Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.""?",False, -7968423,Labetalol causes hypotensive disorder,4026,"For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.","Is the triple ""Labetalol causes hypotensive disorder"" supported by the sentence: ""For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.""?",False, -26371124,Labetalol affects hypertensive disorder,4027,The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.""?",False, -16245918,Labetalol affects stroke disorder,4028,"BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.","Is the triple ""Labetalol affects stroke disorder"" supported by the sentence: ""BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.""?",False, -15472186,Labetalol affects hypertensive disorder,4029,The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.""?",False, -11424839,Labetalol affects hypotensive disorder,4030,The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.,"Is the triple ""Labetalol affects hypotensive disorder"" supported by the sentence: ""The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.""?",False, -24194004,Labetalol prevents preeclampsia,4031,"CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.","Is the triple ""Labetalol prevents preeclampsia"" supported by the sentence: ""CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.""?",False, -16282554,Labetalol prevents hypertensive disorder,4032,"Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.","Is the triple ""Labetalol prevents hypertensive disorder"" supported by the sentence: ""Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.""?",False, -16892434,Labetalol predisposes stroke disorder,4033,"Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.","Is the triple ""Labetalol predisposes stroke disorder"" supported by the sentence: ""Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.""?",False, -15232781,Carvedilol related to hypertensive disorder,4034,Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.,"Is the triple ""Carvedilol related to hypertensive disorder"" supported by the sentence: ""Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.""?",False, -15407113,Carvedilol causes Left ventricular hypertrophy,4035,Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.,"Is the triple ""Carvedilol causes Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.""?",False, -14049404,Carvedilol causes epilepsy,4036,Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.,"Is the triple ""Carvedilol causes epilepsy"" supported by the sentence: ""Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.""?",False, -19046224,Carvedilol affects esophageal varices,4037,Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.,"Is the triple ""Carvedilol affects esophageal varices"" supported by the sentence: ""Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.""?",False, -17542363,Carvedilol affects Left ventricular hypertrophy,4038,"Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.""?",False, -11530189,Carvedilol affects essential hypertension,4039,Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.,"Is the triple ""Carvedilol affects essential hypertension"" supported by the sentence: ""Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.""?",False, -11200172,Carvedilol affects atrial fibrillation,4040,Role of carvedilol in atrial fibrillation: insights from clinical trials.,"Is the triple ""Carvedilol affects atrial fibrillation"" supported by the sentence: ""Role of carvedilol in atrial fibrillation: insights from clinical trials.""?",False, -10614289,Carvedilol affects Stable angina,4041,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects Stable angina"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, -10614288,Carvedilol affects hypertensive disorder,4042,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, -10402879,Carvedilol affects hypertensive disorder,4043,"In addition, carvedilol reduced elevated blood pressure in allografted rats.","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""In addition, carvedilol reduced elevated blood pressure in allografted rats.""?",False, -9269217,Carvedilol affects Left ventricular hypertrophy,4044,"Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.""?",False, -9116913,Carvedilol affects cardiovascular disorder,4045,All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.,"Is the triple ""Carvedilol affects cardiovascular disorder"" supported by the sentence: ""All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.""?",False, -7256243,Carvedilol affects portal hypertension,4046,BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.,"Is the triple ""Carvedilol affects portal hypertension"" supported by the sentence: ""BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.""?",False, -24587957,Carvedilol disrupts portal hypertension,4047,"Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.","Is the triple ""Carvedilol disrupts portal hypertension"" supported by the sentence: ""Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.""?",False, -21108262,Carvedilol disrupts myocardial infarction,4048,"The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.","Is the triple ""Carvedilol disrupts myocardial infarction"" supported by the sentence: ""The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.""?",False, -13210472,Carvedilol disrupts atrial fibrillation,4049,"The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.","Is the triple ""Carvedilol disrupts atrial fibrillation"" supported by the sentence: ""The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.""?",False, -23631897,Carvedilol prevents neoplasm,4050,Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.,"Is the triple ""Carvedilol prevents neoplasm"" supported by the sentence: ""Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.""?",False, -23413400,Carvedilol prevents myocardial infarction,4051,Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.,"Is the triple ""Carvedilol prevents myocardial infarction"" supported by the sentence: ""Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.""?",False, -20796578,Carvedilol prevents hypoglycemia,4052,"To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.","Is the triple ""Carvedilol prevents hypoglycemia"" supported by the sentence: ""To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.""?",False, -17416516,Carvedilol prevents portal hypertension,4053,CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.,"Is the triple ""Carvedilol prevents portal hypertension"" supported by the sentence: ""CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.""?",False, -15996194,Carvedilol prevents hypertensive disorder,4054,Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.,"Is the triple ""Carvedilol prevents hypertensive disorder"" supported by the sentence: ""Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.""?",False, -15794060,Carvedilol prevents Abnormal left ventricular function,4055,Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.,"Is the triple ""Carvedilol prevents Abnormal left ventricular function"" supported by the sentence: ""Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.""?",False, -15707001,Carvedilol prevents kidney disorder,4056,"Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.","Is the triple ""Carvedilol prevents kidney disorder"" supported by the sentence: ""Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.""?",False, -12564717,Carvedilol prevents atrial fibrillation,4057,Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).,"Is the triple ""Carvedilol prevents atrial fibrillation"" supported by the sentence: ""Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).""?",False, -8686828,Carvedilol prevents Left ventricular hypertrophy,4058,Carvedilol reduced LVH by 20%.,"Is the triple ""Carvedilol prevents Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol reduced LVH by 20%.""?",False, -23747042,Carvedilol predisposes type 2 diabetes mellitus,4059,"However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.","Is the triple ""Carvedilol predisposes type 2 diabetes mellitus"" supported by the sentence: ""However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.""?",False, -22663350,Carvedilol predisposes atrial fibrillation,4060,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Carvedilol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, -21640789,Carvedilol predisposes hypoglycemia,4061,"This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.","Is the triple ""Carvedilol predisposes hypoglycemia"" supported by the sentence: ""This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.""?",False, -21331523,Carvedilol predisposes myocardial infarction,4062,The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).,"Is the triple ""Carvedilol predisposes myocardial infarction"" supported by the sentence: ""The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).""?",False, -20291576,Raloxifene related to schizophrenia,4063,A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.,"Is the triple ""Raloxifene related to schizophrenia"" supported by the sentence: ""A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.""?",False, -13558027,Raloxifene related to postmenopausal osteoporosis,4064,Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.,"Is the triple ""Raloxifene related to postmenopausal osteoporosis"" supported by the sentence: ""Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.""?",False, -27583128,Raloxifene causes breast neoplasm,4065,Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.,"Is the triple ""Raloxifene causes breast neoplasm"" supported by the sentence: ""Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.""?",False, -20242808,Raloxifene affects psychotic disorder,4066,"In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.","Is the triple ""Raloxifene affects psychotic disorder"" supported by the sentence: ""In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.""?",False, -16098538,Raloxifene affects schizophrenia,4067,Beneficial effects of add-on raloxifene in schizophrenia.,"Is the triple ""Raloxifene affects schizophrenia"" supported by the sentence: ""Beneficial effects of add-on raloxifene in schizophrenia.""?",False, -15267794,Raloxifene affects Marchiafava-Bignami disease,4068,"To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.","Is the triple ""Raloxifene affects Marchiafava-Bignami disease"" supported by the sentence: ""To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.""?",False, -11233936,Raloxifene affects breast neoplasm,4069,"OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.","Is the triple ""Raloxifene affects breast neoplasm"" supported by the sentence: ""OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.""?",False, -10869334,Raloxifene affects osteoporosis,4070,"While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.","Is the triple ""Raloxifene affects osteoporosis"" supported by the sentence: ""While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.""?",False, -9569313,Raloxifene affects postmenopausal osteoporosis,4071,"Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.","Is the triple ""Raloxifene affects postmenopausal osteoporosis"" supported by the sentence: ""Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.""?",False, -15267792,Raloxifene disrupts Marchiafava-Bignami disease,4072,Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.,"Is the triple ""Raloxifene disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.""?",False, -13369623,Raloxifene disrupts osteoporosis,4073,Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.,"Is the triple ""Raloxifene disrupts osteoporosis"" supported by the sentence: ""Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.""?",False, -7874352,Raloxifene disrupts postmenopausal osteoporosis,4074,The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.,"Is the triple ""Raloxifene disrupts postmenopausal osteoporosis"" supported by the sentence: ""The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.""?",False, -16984197,Raloxifene prevents Alzheimer disease,4075,"We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.","Is the triple ""Raloxifene prevents Alzheimer disease"" supported by the sentence: ""We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.""?",False, -12036378,Raloxifene prevents breast neoplasm,4076,"We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.","Is the triple ""Raloxifene prevents breast neoplasm"" supported by the sentence: ""We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.""?",False, -7813032,Raloxifene prevents postmenopausal osteoporosis,4077,Raloxifene to prevent postmenopausal osteoporosis.,"Is the triple ""Raloxifene prevents postmenopausal osteoporosis"" supported by the sentence: ""Raloxifene to prevent postmenopausal osteoporosis.""?",False, -7578651,Raloxifene prevents osteoporosis,4078,"Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.","Is the triple ""Raloxifene prevents osteoporosis"" supported by the sentence: ""Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.""?",False, -7570810,Raloxifene prevents Marchiafava-Bignami disease,4079,RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.,"Is the triple ""Raloxifene prevents Marchiafava-Bignami disease"" supported by the sentence: ""RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.""?",False, -11746046,Raloxifene predisposes Alzheimer disease,4080,"OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.","Is the triple ""Raloxifene predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.""?",False, -11350173,Raloxifene predisposes osteoporosis,4081,"Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.","Is the triple ""Raloxifene predisposes osteoporosis"" supported by the sentence: ""Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.""?",False, -23481448,Bazedoxifene acetate prevents osteoporosis,4082,"These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.","Is the triple ""Bazedoxifene acetate prevents osteoporosis"" supported by the sentence: ""These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.""?",False, -19905553,Ospemifene disrupts psychologic dyspareunia,4083,"In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.","Is the triple ""Ospemifene disrupts psychologic dyspareunia"" supported by the sentence: ""In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.""?",False, -15516940,Sufentanil affects Pain,4084,The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.,"Is the triple ""Sufentanil affects Pain"" supported by the sentence: ""The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.""?",False, -20743116,Sufentanil prevents delirium,4085,"CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.","Is the triple ""Sufentanil prevents delirium"" supported by the sentence: ""CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.""?",False, -8151024,Sufentanil prevents Pain,4086,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Sufentanil prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, -12819365,Streptomycin related to Buruli ulcer disease,4087,The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.,"Is the triple ""Streptomycin related to Buruli ulcer disease"" supported by the sentence: ""The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.""?",False, -11425591,Streptomycin related to osteomyelitis,4088,Streptomycin in chronic traumatic osteomyelitis.,"Is the triple ""Streptomycin related to osteomyelitis"" supported by the sentence: ""Streptomycin in chronic traumatic osteomyelitis.""?",False, -10417352,Streptomycin related to plague,4089,Role of streptomycin in plague.,"Is the triple ""Streptomycin related to plague"" supported by the sentence: ""Role of streptomycin in plague.""?",False, -10748245,Streptomycin causes plague,4090,[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].,"Is the triple ""Streptomycin causes plague"" supported by the sentence: ""[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].""?",False, -26655494,Streptomycin prevents mycobacterium avium complex disease,4091,"Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.","Is the triple ""Streptomycin prevents mycobacterium avium complex disease"" supported by the sentence: ""Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.""?",False, -14226518,Paromomycin related to cutaneous leishmaniasis,4092,"In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).","Is the triple ""Paromomycin related to cutaneous leishmaniasis"" supported by the sentence: ""In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).""?",False, -12550860,Paromomycin related to visceral leishmaniasis,4093,"Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.","Is the triple ""Paromomycin related to visceral leishmaniasis"" supported by the sentence: ""Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.""?",False, -24692385,Paromomycin affects leishmaniasis,4094,"Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.","Is the triple ""Paromomycin affects leishmaniasis"" supported by the sentence: ""Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.""?",False, -23700620,Paromomycin affects visceral leishmaniasis,4095,The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.,"Is the triple ""Paromomycin affects visceral leishmaniasis"" supported by the sentence: ""The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.""?",False, -22567030,Paromomycin affects cutaneous leishmaniasis,4096,"Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.","Is the triple ""Paromomycin affects cutaneous leishmaniasis"" supported by the sentence: ""Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.""?",False, -27729096,Kanamycin related to bacterial infectious disease,4097,The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.,"Is the triple ""Kanamycin related to bacterial infectious disease"" supported by the sentence: ""The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.""?",False, -10553348,Kanamycin related to tuberculosis,4098,Kanamycin in experimental guinea pig tuberculosis.,"Is the triple ""Kanamycin related to tuberculosis"" supported by the sentence: ""Kanamycin in experimental guinea pig tuberculosis.""?",False, -10567002,Kanamycin affects tuberculosis,4099,Effects of kanamycin in experimental tuberculosis of guinea pigs.,"Is the triple ""Kanamycin affects tuberculosis"" supported by the sentence: ""Effects of kanamycin in experimental tuberculosis of guinea pigs.""?",False, -25418796,Vancomycin related to ulcerative colitis,4100,Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.,"Is the triple ""Vancomycin related to ulcerative colitis"" supported by the sentence: ""Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.""?",False, -24528866,Vancomycin related to bacterial infectious disease,4101,"Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.","Is the triple ""Vancomycin related to bacterial infectious disease"" supported by the sentence: ""Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.""?",False, -23989025,Vancomycin related to Inflammation,4102,"The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.""?",False, -22667296,Vancomycin related to arthropathy,4103,"Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).","Is the triple ""Vancomycin related to arthropathy"" supported by the sentence: ""Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).""?",False, -21740759,Vancomycin related to Infection,4104,"Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.""?",False, -20543239,Vancomycin related to hematopoietic and lymphoid system neoplasm,4105,"Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.","Is the triple ""Vancomycin related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.""?",False, -20099844,Vancomycin related to cystic fibrosis,4106,Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.,"Is the triple ""Vancomycin related to cystic fibrosis"" supported by the sentence: ""Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.""?",False, -18717834,Vancomycin related to eye infectious disorder,4107,"MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.","Is the triple ""Vancomycin related to eye infectious disorder"" supported by the sentence: ""MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.""?",False, -18563763,Vancomycin related to staphylococcal pneumonia,4108,No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.,"Is the triple ""Vancomycin related to staphylococcal pneumonia"" supported by the sentence: ""No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.""?",False, -17578296,Vancomycin related to Peptidoglycan,4109,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, -17578296,Vancomycin related to Peptidoglycan,4110,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, -15843803,Vancomycin related to Diabetic Foot,4111,"With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.","Is the triple ""Vancomycin related to Diabetic Foot"" supported by the sentence: ""With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.""?",False, -15502624,Vancomycin related to abscess,4112,Vancomycin and ciprofloxacin levels were inadequate in most abscesses.,"Is the triple ""Vancomycin related to abscess"" supported by the sentence: ""Vancomycin and ciprofloxacin levels were inadequate in most abscesses.""?",False, -15448370,Vancomycin related to obesity disorder,4113,There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).,"Is the triple ""Vancomycin related to obesity disorder"" supported by the sentence: ""There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).""?",False, -15389679,Vancomycin related to osteomyelitis,4114,Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.,"Is the triple ""Vancomycin related to osteomyelitis"" supported by the sentence: ""Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.""?",False, -15008716,Vancomycin related to peritonitis,4115,CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.""?",False, -14607992,Vancomycin related to pneumonia,4116,"Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.","Is the triple ""Vancomycin related to pneumonia"" supported by the sentence: ""Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.""?",False, -14564943,Vancomycin related to gram-positive bacterial infections,4117,"Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.","Is the triple ""Vancomycin related to gram-positive bacterial infections"" supported by the sentence: ""Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.""?",False, -11348824,Vancomycin related to kidney failure,4118,"The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.","Is the triple ""Vancomycin related to kidney failure"" supported by the sentence: ""The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.""?",False, -11195361,Vancomycin related to Neonatal sepsis,4119,"Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.","Is the triple ""Vancomycin related to Neonatal sepsis"" supported by the sentence: ""Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.""?",False, -10946982,Vancomycin related to respiratory tract infectious disorder,4120,This may give linezolid an advantage over vancomycin in certain respiratory infections.,"Is the triple ""Vancomycin related to respiratory tract infectious disorder"" supported by the sentence: ""This may give linezolid an advantage over vancomycin in certain respiratory infections.""?",False, -10225522,Vancomycin related to bacterial infectious disease with sepsis,4121,These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.,"Is the triple ""Vancomycin related to bacterial infectious disease with sepsis"" supported by the sentence: ""These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.""?",False, -9057886,Vancomycin related to nosocomial infection,4122,A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.,"Is the triple ""Vancomycin related to nosocomial infection"" supported by the sentence: ""A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.""?",False, -9057885,Vancomycin related to staphylococcal infection,4123,Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.,"Is the triple ""Vancomycin related to staphylococcal infection"" supported by the sentence: ""Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.""?",False, -8859000,Vancomycin related to endocarditis,4124,"Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.","Is the triple ""Vancomycin related to endocarditis"" supported by the sentence: ""Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.""?",False, -8170422,Vancomycin related to Sepsis,4125,"DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.","Is the triple ""Vancomycin related to Sepsis"" supported by the sentence: ""DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.""?",False, -23445509,Vancomycin related to peritonitis,4126,Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.""?",False, -22719539,Vancomycin related to Infection,4127,"For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).""?",False, -11098147,Vancomycin related to Inflammation,4128,"Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.""?",False, -14094746,Vancomycin coexists with Peptidoglycan,4129,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, -14094746,Vancomycin coexists with Peptidoglycan,4130,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, -7840667,Vancomycin physically interacts with Peptidoglycan,4131,Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.,"Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.""?",False, -7710804,Vancomycin physically interacts with Peptidoglycan,4132,"The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.","Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.""?",False, -26896148,Vancomycin causes endocarditis,4133,Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.,"Is the triple ""Vancomycin causes endocarditis"" supported by the sentence: ""Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.""?",False, -26320414,Vancomycin causes enterocolitis,4134,"Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.","Is the triple ""Vancomycin causes enterocolitis"" supported by the sentence: ""Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.""?",False, -22849619,Vancomycin causes Infection,4135,"Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).","Is the triple ""Vancomycin causes Infection"" supported by the sentence: ""Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).""?",False, -22231760,Vancomycin causes Inflammation,4136,"Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.","Is the triple ""Vancomycin causes Inflammation"" supported by the sentence: ""Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.""?",False, -21632936,Vancomycin causes bacterial infectious disease with sepsis,4137,"Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.","Is the triple ""Vancomycin causes bacterial infectious disease with sepsis"" supported by the sentence: ""Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.""?",False, -18945219,Vancomycin causes peritonitis,4138,A literature search identified one other published report of vancomycin-induced EP.,"Is the triple ""Vancomycin causes peritonitis"" supported by the sentence: ""A literature search identified one other published report of vancomycin-induced EP.""?",False, -15481792,Vancomycin causes skin disorder,4139,We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.,"Is the triple ""Vancomycin causes skin disorder"" supported by the sentence: ""We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.""?",False, -12001625,Vancomycin causes kidney failure,4140,"The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.","Is the triple ""Vancomycin causes kidney failure"" supported by the sentence: ""The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.""?",False, -9570250,Vancomycin causes nosocomial infection,4141,Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.,"Is the triple ""Vancomycin causes nosocomial infection"" supported by the sentence: ""Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.""?",False, -23893373,Vancomycin affects Infection,4142,"CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.""?",False, -21581118,Vancomycin affects Infection,4143,"As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.""?",False, -21291384,Vancomycin affects hematopoietic and lymphoid system neoplasm,4144,"In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.","Is the triple ""Vancomycin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.""?",False, -20283933,Vancomycin affects enterocolitis,4145,"Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.","Is the triple ""Vancomycin affects enterocolitis"" supported by the sentence: ""Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.""?",False, -19879029,Vancomycin affects cystic fibrosis,4146,"Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.","Is the triple ""Vancomycin affects cystic fibrosis"" supported by the sentence: ""Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.""?",False, -16899271,Vancomycin affects Sepsis,4147,"CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.""?",False, -15270589,Vancomycin affects peritonitis,4148,Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.,"Is the triple ""Vancomycin affects peritonitis"" supported by the sentence: ""Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.""?",False, -13735180,Vancomycin affects pneumonia,4149,"Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.","Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.""?",False, -12348278,Vancomycin affects Sepsis,4150,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, -12348277,Vancomycin affects osteomyelitis,4151,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects osteomyelitis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, -12348276,Vancomycin affects endocarditis,4152,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects endocarditis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, -7991855,Vancomycin affects Peptidoglycan,4153,These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.,"Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.""?",False, -7527991,Vancomycin affects pneumonia,4154,The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.,"Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.""?",False, -17707788,Vancomycin affects Peptidoglycan,4155,"In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.","Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.""?",False, -22719533,Vancomycin disrupts Infection,4156,We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.,"Is the triple ""Vancomycin disrupts Infection"" supported by the sentence: ""We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.""?",False, -21036263,Vancomycin disrupts osteomyelitis,4157,"More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.","Is the triple ""Vancomycin disrupts osteomyelitis"" supported by the sentence: ""More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.""?",False, -19924841,Vancomycin disrupts Inflammation,4158,"More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.","Is the triple ""Vancomycin disrupts Inflammation"" supported by the sentence: ""More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.""?",False, -14538194,Vancomycin disrupts enterocolitis,4159,"Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.","Is the triple ""Vancomycin disrupts enterocolitis"" supported by the sentence: ""Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.""?",False, -21888394,Vancomycin prevents bacterial infectious disease,4160,"Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.","Is the triple ""Vancomycin prevents bacterial infectious disease"" supported by the sentence: ""Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.""?",False, -21518539,Vancomycin prevents Infection,4161,Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .,"Is the triple ""Vancomycin prevents Infection"" supported by the sentence: ""Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .""?",False, -21292683,Vancomycin prevents osteomyelitis,4162,"CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.","Is the triple ""Vancomycin prevents osteomyelitis"" supported by the sentence: ""CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.""?",False, -20759704,Vancomycin prevents kidney failure,4163,Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.,"Is the triple ""Vancomycin prevents kidney failure"" supported by the sentence: ""Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.""?",False, -20759520,Vancomycin prevents arthropathy,4164,"Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.","Is the triple ""Vancomycin prevents arthropathy"" supported by the sentence: ""Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.""?",False, -16424860,Vancomycin prevents pneumonia,4165,"Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.","Is the triple ""Vancomycin prevents pneumonia"" supported by the sentence: ""Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.""?",False, -11136130,Vancomycin prevents nosocomial infection,4166,"Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.","Is the triple ""Vancomycin prevents nosocomial infection"" supported by the sentence: ""Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.""?",False, -8520533,Vancomycin prevents peritonitis,4167,The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.,"Is the triple ""Vancomycin prevents peritonitis"" supported by the sentence: ""The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.""?",False, -8203212,Vancomycin prevents endocarditis,4168,"Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.","Is the triple ""Vancomycin prevents endocarditis"" supported by the sentence: ""Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.""?",False, -8170423,Vancomycin prevents Neonatal sepsis,4169,MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.,"Is the triple ""Vancomycin prevents Neonatal sepsis"" supported by the sentence: ""MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.""?",False, -8170420,Vancomycin prevents Sepsis,4170,REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.,"Is the triple ""Vancomycin prevents Sepsis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.""?",False, -7111089,Vancomycin prevents Inflammation,4171,We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.,"Is the triple ""Vancomycin prevents Inflammation"" supported by the sentence: ""We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.""?",False, -25178384,Vancomycin exacerbates Inflammation,4172,"Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.","Is the triple ""Vancomycin exacerbates Inflammation"" supported by the sentence: ""Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.""?",False, -21622859,Vancomycin exacerbates pneumonia,4173,The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.,"Is the triple ""Vancomycin exacerbates pneumonia"" supported by the sentence: ""The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.""?",False, -21314122,Vancomycin predisposes Sepsis,4174,"OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.","Is the triple ""Vancomycin predisposes Sepsis"" supported by the sentence: ""OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.""?",False, -19879549,Vancomycin predisposes kidney failure,4175,"Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.","Is the triple ""Vancomycin predisposes kidney failure"" supported by the sentence: ""Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.""?",False, -18555479,Vancomycin predisposes pneumonia,4176,"Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.","Is the triple ""Vancomycin predisposes pneumonia"" supported by the sentence: ""Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.""?",False, -18327103,Vancomycin predisposes nosocomial infection,4177,"CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.","Is the triple ""Vancomycin predisposes nosocomial infection"" supported by the sentence: ""CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.""?",False, -12689487,Vancomycin predisposes bacterial infectious disease with sepsis,4178,"CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.","Is the triple ""Vancomycin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.""?",False, -12018679,LENOGRASTIM related to plasma cell myeloma,4179,We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.,"Is the triple ""LENOGRASTIM related to plasma cell myeloma"" supported by the sentence: ""We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.""?",False, -24207855,SARGRAMOSTIM related to pulmonary alveolar proteinosis,4180,NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.,"Is the triple ""SARGRAMOSTIM related to pulmonary alveolar proteinosis"" supported by the sentence: ""NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.""?",False, -23712911,SARGRAMOSTIM related to Sepsis,4181,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to Sepsis"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, -23712910,SARGRAMOSTIM related to adult acute respiratory distress syndrome,4182,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to adult acute respiratory distress syndrome"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, -23177848,SARGRAMOSTIM related to Alzheimer disease,4183,An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.,"Is the triple ""SARGRAMOSTIM related to Alzheimer disease"" supported by the sentence: ""An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.""?",False, -16827749,SARGRAMOSTIM related to prostate cancer,4184,Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.,"Is the triple ""SARGRAMOSTIM related to prostate cancer"" supported by the sentence: ""Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.""?",False, -11846978,SARGRAMOSTIM related to Crohn disease,4185,Preliminary studies suggest sargramostim may have activity in Crohn's disease.,"Is the triple ""SARGRAMOSTIM related to Crohn disease"" supported by the sentence: ""Preliminary studies suggest sargramostim may have activity in Crohn's disease.""?",False, -7671811,SARGRAMOSTIM related to HIV infectious disease,4186,"Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.","Is the triple ""SARGRAMOSTIM related to HIV infectious disease"" supported by the sentence: ""Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.""?",False, -7896656,SARGRAMOSTIM prevents neutropenia,4187,Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.,"Is the triple ""SARGRAMOSTIM prevents neutropenia"" supported by the sentence: ""Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.""?",False, -27611311,Filgrastim related to sarcoma,4188,Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.,"Is the triple ""Filgrastim related to sarcoma"" supported by the sentence: ""Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.""?",False, -26602673,Filgrastim related to acute lymphoblastic leukemia,4189,Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.,"Is the triple ""Filgrastim related to acute lymphoblastic leukemia"" supported by the sentence: ""Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.""?",False, -26505391,Filgrastim related to Hodgkins lymphoma,4190,"CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.","Is the triple ""Filgrastim related to Hodgkins lymphoma"" supported by the sentence: ""CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.""?",False, -23038064,Filgrastim related to Infection,4191,"RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.","Is the triple ""Filgrastim related to Infection"" supported by the sentence: ""RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.""?",False, -22749433,Filgrastim related to neoplasm,4192,"Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.","Is the triple ""Filgrastim related to neoplasm"" supported by the sentence: ""Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.""?",False, -19713781,Filgrastim related to lymphoma,4193,A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.,"Is the triple ""Filgrastim related to lymphoma"" supported by the sentence: ""A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.""?",False, -18903615,Filgrastim related to HIV infectious disease,4194,"Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.","Is the triple ""Filgrastim related to HIV infectious disease"" supported by the sentence: ""Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.""?",False, -17402873,Filgrastim related to acute myeloid leukemia,4195,"Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.","Is the triple ""Filgrastim related to acute myeloid leukemia"" supported by the sentence: ""Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.""?",False, -16080456,Filgrastim related to plasma cell myeloma,4196,"Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).","Is the triple ""Filgrastim related to plasma cell myeloma"" supported by the sentence: ""Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).""?",False, -14467347,Filgrastim related to myocardial infarction,4197,"Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.","Is the triple ""Filgrastim related to myocardial infarction"" supported by the sentence: ""Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.""?",False, -13860825,Filgrastim related to small cell lung carcinoma,4198,Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.,"Is the triple ""Filgrastim related to small cell lung carcinoma"" supported by the sentence: ""Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.""?",False, -10253688,Filgrastim related to ovarian cancer,4199,"Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.","Is the triple ""Filgrastim related to ovarian cancer"" supported by the sentence: ""Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.""?",False, -9334871,Filgrastim related to non-small cell lung carcinoma,4200,"A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.","Is the triple ""Filgrastim related to non-small cell lung carcinoma"" supported by the sentence: ""A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.""?",False, -7868897,Filgrastim related to neutropenia,4201,"Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.","Is the triple ""Filgrastim related to neutropenia"" supported by the sentence: ""Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.""?",False, -7775323,Filgrastim related to non-Hodgkin lymphoma,4202,Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.,"Is the triple ""Filgrastim related to non-Hodgkin lymphoma"" supported by the sentence: ""Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.""?",False, -13176527,Filgrastim has part non-Hodgkin lymphoma,4203,Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.,"Is the triple ""Filgrastim has part non-Hodgkin lymphoma"" supported by the sentence: ""Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.""?",False, -27488127,Filgrastim causes acute myeloid leukemia,4204,"The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.","Is the triple ""Filgrastim causes acute myeloid leukemia"" supported by the sentence: ""The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.""?",False, -26596932,Filgrastim causes acute lymphoblastic leukemia,4205,Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.,"Is the triple ""Filgrastim causes acute lymphoblastic leukemia"" supported by the sentence: ""Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.""?",False, -19245347,Filgrastim causes myeloproliferative neoplasm,4206,Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.,"Is the triple ""Filgrastim causes myeloproliferative neoplasm"" supported by the sentence: ""Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.""?",False, -8419399,Filgrastim causes neutropenia,4207,Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.,"Is the triple ""Filgrastim causes neutropenia"" supported by the sentence: ""Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.""?",False, -26496059,Filgrastim affects neutropenia,4208,"The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.","Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.""?",False, -15351355,Filgrastim affects Fever,4209,"Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.","Is the triple ""Filgrastim affects Fever"" supported by the sentence: ""Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.""?",False, -7868413,Filgrastim affects neutropenia,4210,Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.,"Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.""?",False, -9501874,Filgrastim disrupts neutropenia,4211,Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.,"Is the triple ""Filgrastim disrupts neutropenia"" supported by the sentence: ""Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.""?",False, -14309803,Filgrastim prevents non-Hodgkin lymphoma,4212,"The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).","Is the triple ""Filgrastim prevents non-Hodgkin lymphoma"" supported by the sentence: ""The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).""?",False, -7265196,Filgrastim prevents neutropenia,4213,We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.,"Is the triple ""Filgrastim prevents neutropenia"" supported by the sentence: ""We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.""?",False, -16134815,Filgrastim predisposes hematopoietic and lymphoid system neoplasm,4214,BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.,"Is the triple ""Filgrastim predisposes hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.""?",False, -14495646,Filgrastim predisposes neutropenia,4215,"Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.","Is the triple ""Filgrastim predisposes neutropenia"" supported by the sentence: ""Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.""?",False, -12306052,Tibolone affects physiological sexual disorder,4216,"Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.","Is the triple ""Tibolone affects physiological sexual disorder"" supported by the sentence: ""Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.""?",False, -7873396,Tibolone prevents osteoporosis,4217,"In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.","Is the triple ""Tibolone prevents osteoporosis"" supported by the sentence: ""In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.""?",False, -17565484,Cosyntropin affects West syndrome,4218,"TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.","Is the triple ""Cosyntropin affects West syndrome"" supported by the sentence: ""TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.""?",False, -11757081,Cosyntropin disrupts hypertensive disorder,4219,In one child synthetic ACTH was stopped because of arterial hypertension.,"Is the triple ""Cosyntropin disrupts hypertensive disorder"" supported by the sentence: ""In one child synthetic ACTH was stopped because of arterial hypertension.""?",False, -19585114,Corticotropin related to chronic progressive multiple sclerosis,4220,Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.,"Is the triple ""Corticotropin related to chronic progressive multiple sclerosis"" supported by the sentence: ""Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.""?",False, -15839924,Corticotropin related to membranous glomerulonephritis,4221,The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.,"Is the triple ""Corticotropin related to membranous glomerulonephritis"" supported by the sentence: ""The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.""?",False, -10947313,Corticotropin related to polycystic ovary syndrome,4222,"CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.","Is the triple ""Corticotropin related to polycystic ovary syndrome"" supported by the sentence: ""CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.""?",False, -10518316,Corticotropin related to dermatomyositis,4223,Corticotrophin and cortisone therapy in dermatomyositis.,"Is the triple ""Corticotropin related to dermatomyositis"" supported by the sentence: ""Corticotrophin and cortisone therapy in dermatomyositis.""?",False, -10489579,Corticotropin related to epilepsy,4224,[Observations on several cases of epilepsy in children with ACTH and cortisone].,"Is the triple ""Corticotropin related to epilepsy"" supported by the sentence: ""[Observations on several cases of epilepsy in children with ACTH and cortisone].""?",False, -10438408,Corticotropin related to nephrotic syndrome,4225,Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.,"Is the triple ""Corticotropin related to nephrotic syndrome"" supported by the sentence: ""Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.""?",False, -10431205,Corticotropin related to sarcoidosis,4226,[ACTH and cortisone in sarcoidosis; preliminary report].,"Is the triple ""Corticotropin related to sarcoidosis"" supported by the sentence: ""[ACTH and cortisone in sarcoidosis; preliminary report].""?",False, -10427009,Corticotropin related to optic neuritis,4227,Intravenous use of corticotropin in optic neuritis.,"Is the triple ""Corticotropin related to optic neuritis"" supported by the sentence: ""Intravenous use of corticotropin in optic neuritis.""?",False, -9718321,Corticotropin related to rheumatoid arthritis,4228,"ACTH, cortisol and prolactin in active rheumatoid arthritis.","Is the triple ""Corticotropin related to rheumatoid arthritis"" supported by the sentence: ""ACTH, cortisol and prolactin in active rheumatoid arthritis.""?",False, -8496620,Corticotropin related to multiple sclerosis,4229,Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.,"Is the triple ""Corticotropin related to multiple sclerosis"" supported by the sentence: ""Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.""?",False, -7394246,Corticotropin related to West syndrome,4230,ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.,"Is the triple ""Corticotropin related to West syndrome"" supported by the sentence: ""ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.""?",False, -22849896,Corticotropin causes West syndrome,4231,Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.,"Is the triple ""Corticotropin causes West syndrome"" supported by the sentence: ""Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.""?",False, -12436107,Corticotropin causes epilepsy,4232,"The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.","Is the triple ""Corticotropin causes epilepsy"" supported by the sentence: ""The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.""?",False, -11010111,Corticotropin causes rheumatoid arthritis,4233,The natural course of rheumatoid arthritis and the changes induced by ACTH.,"Is the triple ""Corticotropin causes rheumatoid arthritis"" supported by the sentence: ""The natural course of rheumatoid arthritis and the changes induced by ACTH.""?",False, -17565428,Corticotropin affects West syndrome,4234,Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.,"Is the triple ""Corticotropin affects West syndrome"" supported by the sentence: ""Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.""?",False, -15783986,Corticotropin affects multiple sclerosis,4235,"At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.","Is the triple ""Corticotropin affects multiple sclerosis"" supported by the sentence: ""At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.""?",False, -15695412,Corticotropin affects polycystic ovary syndrome,4236,Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.,"Is the triple ""Corticotropin affects polycystic ovary syndrome"" supported by the sentence: ""Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.""?",False, -11427275,Corticotropin affects dermatomyositis,4237,The effect of pituitary adrenocorticotropin in dermatomyositis.,"Is the triple ""Corticotropin affects dermatomyositis"" supported by the sentence: ""The effect of pituitary adrenocorticotropin in dermatomyositis.""?",False, -10737513,Corticotropin affects sarcoidosis,4238,The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).,"Is the triple ""Corticotropin affects sarcoidosis"" supported by the sentence: ""The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).""?",False, -10422766,Corticotropin affects rheumatoid arthritis,4239,On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.,"Is the triple ""Corticotropin affects rheumatoid arthritis"" supported by the sentence: ""On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.""?",False, -9312832,Corticotropin affects epilepsy,4240,"The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).","Is the triple ""Corticotropin affects epilepsy"" supported by the sentence: ""The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).""?",False, -15159690,Corticotropin disrupts epilepsy,4241,AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.,"Is the triple ""Corticotropin disrupts epilepsy"" supported by the sentence: ""AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.""?",False, -27033387,Corticotropin prevents West syndrome,4242,Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.,"Is the triple ""Corticotropin prevents West syndrome"" supported by the sentence: ""Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.""?",False, -10517176,Corticotropin prevents epilepsy,4243,"Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.","Is the triple ""Corticotropin prevents epilepsy"" supported by the sentence: ""Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.""?",False, -23224982,Corticotropin predisposes epilepsy,4244,"The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.","Is the triple ""Corticotropin predisposes epilepsy"" supported by the sentence: ""The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.""?",False, -15800284,Dabigatran etexilate related to atrial fibrillation,4245,"In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.","Is the triple ""Dabigatran etexilate related to atrial fibrillation"" supported by the sentence: ""In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.""?",False, -16972150,Dabigatran etexilate affects stroke disorder,4246,This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.,"Is the triple ""Dabigatran etexilate affects stroke disorder"" supported by the sentence: ""This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.""?",False, -21262475,Dabigatran etexilate prevents thrombophilia due to thrombin defect,4247,Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.,"Is the triple ""Dabigatran etexilate prevents thrombophilia due to thrombin defect"" supported by the sentence: ""Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.""?",False, -19084221,Dabigatran etexilate prevents thrombotic disease,4248,"A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.","Is the triple ""Dabigatran etexilate prevents thrombotic disease"" supported by the sentence: ""A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.""?",False, -14524874,Dabigatran etexilate prevents stroke disorder,4249,"Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.","Is the triple ""Dabigatran etexilate prevents stroke disorder"" supported by the sentence: ""Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.""?",False, -11599698,Dabigatran etexilate prevents Thromboembolism,4250,"A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.","Is the triple ""Dabigatran etexilate prevents Thromboembolism"" supported by the sentence: ""A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.""?",False, -15929248,Dabigatran etexilate predisposes stroke disorder,4251,"Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.","Is the triple ""Dabigatran etexilate predisposes stroke disorder"" supported by the sentence: ""Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.""?",False, -13343476,Dabigatran etexilate predisposes Thromboembolism,4252,"INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.","Is the triple ""Dabigatran etexilate predisposes Thromboembolism"" supported by the sentence: ""INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.""?",False, -10867084,Ximelagatran related to atrial fibrillation,4253,Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.,"Is the triple ""Ximelagatran related to atrial fibrillation"" supported by the sentence: ""Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.""?",False, -12162541,Ximelagatran prevents thrombotic disease,4254,A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.,"Is the triple ""Ximelagatran prevents thrombotic disease"" supported by the sentence: ""A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.""?",False, -9396435,Ximelagatran prevents Thromboembolism,4255,"In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.","Is the triple ""Ximelagatran prevents Thromboembolism"" supported by the sentence: ""In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.""?",False, -13148663,Ximelagatran predisposes Thromboembolism,4256,"OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.","Is the triple ""Ximelagatran predisposes Thromboembolism"" supported by the sentence: ""OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.""?",False, -24220155,Bivalirudin related to Hemorrhage,4257,"CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.""?",False, -23845334,Bivalirudin related to thrombocytopenia,4258,"Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).","Is the triple ""Bivalirudin related to thrombocytopenia"" supported by the sentence: ""Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).""?",False, -21128552,Bivalirudin related to heart disorder,4259,"AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.","Is the triple ""Bivalirudin related to heart disorder"" supported by the sentence: ""AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.""?",False, -16166302,Bivalirudin related to coronary artery disorder,4260,Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.,"Is the triple ""Bivalirudin related to coronary artery disorder"" supported by the sentence: ""Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.""?",False, -9469606,Bivalirudin related to myocardial infarction,4261,"Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.","Is the triple ""Bivalirudin related to myocardial infarction"" supported by the sentence: ""Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.""?",False, -9060136,Bivalirudin related to acute coronary syndrome,4262,Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.,"Is the triple ""Bivalirudin related to acute coronary syndrome"" supported by the sentence: ""Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.""?",False, -21743704,Bivalirudin related to Hemorrhage,4263,"On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.""?",False, -18003165,Bivalirudin related to thrombotic disease,4264,"CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.","Is the triple ""Bivalirudin related to thrombotic disease"" supported by the sentence: ""CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.""?",False, -15575490,Bivalirudin causes myocardial infarction,4265,These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.,"Is the triple ""Bivalirudin causes myocardial infarction"" supported by the sentence: ""These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.""?",False, -10298579,Bivalirudin causes Hemorrhage,4266,"However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).","Is the triple ""Bivalirudin causes Hemorrhage"" supported by the sentence: ""However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).""?",False, -19056194,Bivalirudin affects thrombotic disease,4267,Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.""?",False, -15575489,Bivalirudin affects thrombotic disease,4268,DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).""?",False, -14748514,Bivalirudin affects myocardial infarction,4269,"Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.","Is the triple ""Bivalirudin affects myocardial infarction"" supported by the sentence: ""Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.""?",False, -14318099,Bivalirudin affects Hemorrhage,4270,Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.,"Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.""?",False, -9597163,Bivalirudin affects Hemorrhage,4271,"In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.","Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.""?",False, -19316921,Bivalirudin disrupts myocardial infarction,4272,"CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.","Is the triple ""Bivalirudin disrupts myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.""?",False, -19056195,Bivalirudin disrupts thrombotic disease,4273,"BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.","Is the triple ""Bivalirudin disrupts thrombotic disease"" supported by the sentence: ""BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.""?",False, -13525067,Bivalirudin disrupts acute coronary syndrome,4274,Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.,"Is the triple ""Bivalirudin disrupts acute coronary syndrome"" supported by the sentence: ""Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.""?",False, -13434992,Bivalirudin disrupts Hemorrhage,4275,"Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.","Is the triple ""Bivalirudin disrupts Hemorrhage"" supported by the sentence: ""Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.""?",False, -21793150,Bivalirudin prevents Hemorrhage,4276,Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.,"Is the triple ""Bivalirudin prevents Hemorrhage"" supported by the sentence: ""Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.""?",False, -20637086,Bivalirudin prevents syndromic disease,4277,Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.,"Is the triple ""Bivalirudin prevents syndromic disease"" supported by the sentence: ""Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.""?",False, -17823880,Bivalirudin prevents myocardial infarction,4278,"This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).","Is the triple ""Bivalirudin prevents myocardial infarction"" supported by the sentence: ""This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).""?",False, -10215156,Bivalirudin prevents thrombotic disease,4279,Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.,"Is the triple ""Bivalirudin prevents thrombotic disease"" supported by the sentence: ""Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.""?",False, -22425248,Bivalirudin predisposes Hemorrhage,4280,"Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.","Is the triple ""Bivalirudin predisposes Hemorrhage"" supported by the sentence: ""Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.""?",False, -16276306,Bivalirudin predisposes thrombotic disease,4281,"Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.","Is the triple ""Bivalirudin predisposes thrombotic disease"" supported by the sentence: ""Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.""?",False, -14172527,Bivalirudin predisposes myocardial infarction,4282,A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).,"Is the triple ""Bivalirudin predisposes myocardial infarction"" supported by the sentence: ""A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).""?",False, -17086386,Melagatran disrupts thrombotic disease,4283,"The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.","Is the triple ""Melagatran disrupts thrombotic disease"" supported by the sentence: ""The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.""?",False, -9182682,Lepirudin related to thrombotic disease,4284,"Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.","Is the triple ""Lepirudin related to thrombotic disease"" supported by the sentence: ""Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.""?",False, -27183131,Lepirudin affects thrombotic disease,4285,Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.,"Is the triple ""Lepirudin affects thrombotic disease"" supported by the sentence: ""Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.""?",False, -26612130,Lepirudin disrupts thrombotic disease,4286,Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.,"Is the triple ""Lepirudin disrupts thrombotic disease"" supported by the sentence: ""Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.""?",False, -9038512,Lepirudin prevents thrombotic disease,4287,"Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.","Is the triple ""Lepirudin prevents thrombotic disease"" supported by the sentence: ""Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.""?",False, -24074121,Ripasudil affects Fuchs' endothelial dystrophy,4288,"Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).","Is the triple ""Ripasudil affects Fuchs' endothelial dystrophy"" supported by the sentence: ""Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).""?",False, -23144840,Netarsudil prevents corneal edema,4289,CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.,"Is the triple ""Netarsudil prevents corneal edema"" supported by the sentence: ""CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.""?",False, -21457868,Netarsudil prevents open-angle glaucoma,4290,Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.,"Is the triple ""Netarsudil prevents open-angle glaucoma"" supported by the sentence: ""Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.""?",False, -25249408,Calcitriol related to Hypocalcemia,4291,We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.,"Is the triple ""Calcitriol related to Hypocalcemia"" supported by the sentence: ""We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.""?",False, -24424216,Calcitriol related to Crohn disease,4292,"From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].","Is the triple ""Calcitriol related to Crohn disease"" supported by the sentence: ""From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].""?",False, -23057137,Calcitriol related to acute kidney failure,4293,Production and metabolic clearance of calcitriol in acute renal failure.,"Is the triple ""Calcitriol related to acute kidney failure"" supported by the sentence: ""Production and metabolic clearance of calcitriol in acute renal failure.""?",False, -21048179,Calcitriol related to breast neoplasm,4294,"In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.","Is the triple ""Calcitriol related to breast neoplasm"" supported by the sentence: ""In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.""?",False, -18873537,Calcitriol related to diabetic kidney disease,4295,"The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.","Is the triple ""Calcitriol related to diabetic kidney disease"" supported by the sentence: ""The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.""?",False, -17759117,Calcitriol related to Sepsis,4296,Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.,"Is the triple ""Calcitriol related to Sepsis"" supported by the sentence: ""Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.""?",False, -17014883,Calcitriol related to hypoparathyroidism,4297,We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.,"Is the triple ""Calcitriol related to hypoparathyroidism"" supported by the sentence: ""We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.""?",False, -16783681,Calcitriol related to non-small cell lung carcinoma,4298,A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.,"Is the triple ""Calcitriol related to non-small cell lung carcinoma"" supported by the sentence: ""A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.""?",False, -16670490,Calcitriol related to postmenopausal osteoporosis,4299,Long-term treatment with calcitriol in postmenopausal osteoporosis.,"Is the triple ""Calcitriol related to postmenopausal osteoporosis"" supported by the sentence: ""Long-term treatment with calcitriol in postmenopausal osteoporosis.""?",False, -16084679,Calcitriol related to hypertensive disorder,4300,"AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.","Is the triple ""Calcitriol related to hypertensive disorder"" supported by the sentence: ""AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.""?",False, -15183062,Calcitriol related to type 1 diabetes mellitus,4301,OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.,"Is the triple ""Calcitriol related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.""?",False, -13574949,Calcitriol related to neoplasm,4302,"We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.","Is the triple ""Calcitriol related to neoplasm"" supported by the sentence: ""We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.""?",False, -13228040,Calcitriol related to castration-resistant prostate carcinoma,4303,"Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.","Is the triple ""Calcitriol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.""?",False, -11632117,Calcitriol related to prostate cancer,4304,Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.,"Is the triple ""Calcitriol related to prostate cancer"" supported by the sentence: ""Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.""?",False, -11549262,Calcitriol related to renal osteodystrophy,4305,"In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.","Is the triple ""Calcitriol related to renal osteodystrophy"" supported by the sentence: ""In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.""?",False, -11138207,Calcitriol related to skin basal cell carcinoma,4306,"RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.","Is the triple ""Calcitriol related to skin basal cell carcinoma"" supported by the sentence: ""RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.""?",False, -9056874,Calcitriol related to psoriasis,4307,"Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.","Is the triple ""Calcitriol related to psoriasis"" supported by the sentence: ""Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.""?",False, -8335532,Calcitriol related to chronic kidney disease,4308,This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.,"Is the triple ""Calcitriol related to chronic kidney disease"" supported by the sentence: ""This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.""?",False, -7638906,Calcitriol related to myelodysplastic syndrome,4309,Calcitriol in myelodysplastic syndromes.,"Is the triple ""Calcitriol related to myelodysplastic syndrome"" supported by the sentence: ""Calcitriol in myelodysplastic syndromes.""?",False, -7210521,Calcitriol related to osteoporosis,4310,"To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.","Is the triple ""Calcitriol related to osteoporosis"" supported by the sentence: ""To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.""?",False, -23300761,Calcitriol causes hypoparathyroidism,4311,Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.,"Is the triple ""Calcitriol causes hypoparathyroidism"" supported by the sentence: ""Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.""?",False, -22190855,Calcitriol causes Hypocalcemia,4312,"At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.","Is the triple ""Calcitriol causes Hypocalcemia"" supported by the sentence: ""At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.""?",False, -13672029,Calcitriol causes renal osteodystrophy,4313,"Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.","Is the triple ""Calcitriol causes renal osteodystrophy"" supported by the sentence: ""Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.""?",False, -8610431,Calcitriol causes neoplasm,4314,In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.,"Is the triple ""Calcitriol causes neoplasm"" supported by the sentence: ""In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.""?",False, -26699785,Calcitriol affects myelodysplastic syndrome,4315,"Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.","Is the triple ""Calcitriol affects myelodysplastic syndrome"" supported by the sentence: ""Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.""?",False, -26649101,Calcitriol affects psoriasis,4316,Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.,"Is the triple ""Calcitriol affects psoriasis"" supported by the sentence: ""Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.""?",False, -20118335,Calcitriol affects chronic kidney disease,4317,"A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.","Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.""?",False, -18144364,Calcitriol affects diabetic kidney disease,4318,CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.,"Is the triple ""Calcitriol affects diabetic kidney disease"" supported by the sentence: ""CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.""?",False, -17907580,Calcitriol affects breast neoplasm,4319,In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.,"Is the triple ""Calcitriol affects breast neoplasm"" supported by the sentence: ""In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.""?",False, -15840384,Calcitriol affects skin basal cell carcinoma,4320,Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.,"Is the triple ""Calcitriol affects skin basal cell carcinoma"" supported by the sentence: ""Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.""?",False, -15206874,Calcitriol affects neoplasm,4321,Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.""?",False, -15145405,Calcitriol affects neoplasm,4322,Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.""?",False, -10932246,Calcitriol affects chronic kidney disease,4323,Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.,"Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.""?",False, -9912093,Calcitriol affects prostate cancer,4324,Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.,"Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.""?",False, -9912091,Calcitriol affects prostate cancer,4325,"As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.","Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.""?",False, -26695789,Calcitriol produces renal osteodystrophy,4326,Renal osteodystrophy may be modulated by extrarenal production of calcitriol.,"Is the triple ""Calcitriol produces renal osteodystrophy"" supported by the sentence: ""Renal osteodystrophy may be modulated by extrarenal production of calcitriol.""?",False, -14288417,Calcitriol produces Crohn disease,4327,"Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).","Is the triple ""Calcitriol produces Crohn disease"" supported by the sentence: ""Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).""?",False, -19013737,Calcitriol disrupts chronic kidney disease,4328,"Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.","Is the triple ""Calcitriol disrupts chronic kidney disease"" supported by the sentence: ""Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.""?",False, -17492128,Calcitriol disrupts prostate cancer,4329,"Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).","Is the triple ""Calcitriol disrupts prostate cancer"" supported by the sentence: ""Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).""?",False, -15711853,Calcitriol disrupts neoplasm,4330,"Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.","Is the triple ""Calcitriol disrupts neoplasm"" supported by the sentence: ""Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.""?",False, -23005720,Calcitriol prevents neoplasm,4331,"We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.","Is the triple ""Calcitriol prevents neoplasm"" supported by the sentence: ""We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.""?",False, -22688863,Calcitriol prevents Hypocalcemia,4332,"Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.","Is the triple ""Calcitriol prevents Hypocalcemia"" supported by the sentence: ""Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.""?",False, -18398383,Calcitriol prevents diabetic kidney disease,4333,OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).,"Is the triple ""Calcitriol prevents diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).""?",False, -17492127,Calcitriol prevents prostate cancer,4334,"To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)","Is the triple ""Calcitriol prevents prostate cancer"" supported by the sentence: ""To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)""?",False, -8346486,Calcitriol prevents osteoporosis,4335,Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.,"Is the triple ""Calcitriol prevents osteoporosis"" supported by the sentence: ""Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.""?",False, -8053720,Calcitriol prevents postmenopausal osteoporosis,4336,CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.,"Is the triple ""Calcitriol prevents postmenopausal osteoporosis"" supported by the sentence: ""CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.""?",False, -24886178,Calcitriol exacerbates Sepsis,4337,"Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.","Is the triple ""Calcitriol exacerbates Sepsis"" supported by the sentence: ""Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.""?",False, -18653087,Calcitriol exacerbates hypertensive disorder,4338,"Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.","Is the triple ""Calcitriol exacerbates hypertensive disorder"" supported by the sentence: ""Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.""?",False, -21373396,Calcitriol predisposes chronic kidney disease,4339,"Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.","Is the triple ""Calcitriol predisposes chronic kidney disease"" supported by the sentence: ""Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.""?",False, -17377804,Calcitriol predisposes hypertensive disorder,4340,Calcitriol deficiency is a risk factor for DM and hypertension.,"Is the triple ""Calcitriol predisposes hypertensive disorder"" supported by the sentence: ""Calcitriol deficiency is a risk factor for DM and hypertension.""?",False, -16828204,Calcitriol predisposes osteoporosis,4341,OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.,"Is the triple ""Calcitriol predisposes osteoporosis"" supported by the sentence: ""OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.""?",False, -9760670,Calcitriol predisposes prostate cancer,4342,"Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.","Is the triple ""Calcitriol predisposes prostate cancer"" supported by the sentence: ""Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.""?",False, -26462827,Alfacalcidol related to kidney failure,4343,The use of alfacalcidol in the prevention of bone disease in early renal failure.,"Is the triple ""Alfacalcidol related to kidney failure"" supported by the sentence: ""The use of alfacalcidol in the prevention of bone disease in early renal failure.""?",False, -9037270,Alfacalcidol related to postmenopausal osteoporosis,4344,"We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.","Is the triple ""Alfacalcidol related to postmenopausal osteoporosis"" supported by the sentence: ""We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.""?",False, -7210524,Alfacalcidol related to osteoporosis,4345,"These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.","Is the triple ""Alfacalcidol related to osteoporosis"" supported by the sentence: ""These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.""?",False, -22711685,Alfacalcidol causes osteoporosis,4346,"Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.","Is the triple ""Alfacalcidol causes osteoporosis"" supported by the sentence: ""Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.""?",False, -26635675,Alfacalcidol affects kidney failure,4347,"Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.","Is the triple ""Alfacalcidol affects kidney failure"" supported by the sentence: ""Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.""?",False, -21927698,Alfacalcidol affects myopathy,4348,This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.,"Is the triple ""Alfacalcidol affects myopathy"" supported by the sentence: ""This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.""?",False, -11900508,Alfacalcidol affects postmenopausal osteoporosis,4349,"The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.","Is the triple ""Alfacalcidol affects postmenopausal osteoporosis"" supported by the sentence: ""The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.""?",False, -8505855,Alfacalcidol affects osteoporosis,4350,Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.,"Is the triple ""Alfacalcidol affects osteoporosis"" supported by the sentence: ""Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.""?",False, -20641062,Alfacalcidol disrupts osteoporosis,4351,The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.,"Is the triple ""Alfacalcidol disrupts osteoporosis"" supported by the sentence: ""The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.""?",False, -21927699,Alfacalcidol prevents myopathy,4352,Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.,"Is the triple ""Alfacalcidol prevents myopathy"" supported by the sentence: ""Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.""?",False, -7684744,Alfacalcidol prevents osteoporosis,4353,"There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.","Is the triple ""Alfacalcidol prevents osteoporosis"" supported by the sentence: ""There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.""?",False, -7684734,Alfacalcidol prevents postmenopausal osteoporosis,4354,Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.,"Is the triple ""Alfacalcidol prevents postmenopausal osteoporosis"" supported by the sentence: ""Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.""?",False, -24020567,Cholecalciferol related to male infertility,4355,Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.,"Is the triple ""Cholecalciferol related to male infertility"" supported by the sentence: ""Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.""?",False, -23185349,Cholecalciferol related to ulcerative colitis,4356,Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.,"Is the triple ""Cholecalciferol related to ulcerative colitis"" supported by the sentence: ""Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.""?",False, -22584995,Cholecalciferol related to acute myeloid leukemia,4357,"CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.","Is the triple ""Cholecalciferol related to acute myeloid leukemia"" supported by the sentence: ""CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.""?",False, -21514930,Cholecalciferol related to Infection,4358,"Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.","Is the triple ""Cholecalciferol related to Infection"" supported by the sentence: ""Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.""?",False, -21254434,Cholecalciferol related to depressive disorder,4359,"Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.","Is the triple ""Cholecalciferol related to depressive disorder"" supported by the sentence: ""Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.""?",False, -20389616,Cholecalciferol related to anemia,4360,Proportion of anemia increased by trimester among women with colecalciferol deficiency.,"Is the triple ""Cholecalciferol related to anemia"" supported by the sentence: ""Proportion of anemia increased by trimester among women with colecalciferol deficiency.""?",False, -20190699,Cholecalciferol related to autism spectrum disorder,4361,Untangling the most probable role for vitamin D3 in autism.,"Is the triple ""Cholecalciferol related to autism spectrum disorder"" supported by the sentence: ""Untangling the most probable role for vitamin D3 in autism.""?",False, -19639056,Cholecalciferol related to pulmonary tuberculosis,4362,Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.,"Is the triple ""Cholecalciferol related to pulmonary tuberculosis"" supported by the sentence: ""Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.""?",False, -18980881,Cholecalciferol related to chronic obstructive pulmonary disease,4363,"These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.","Is the triple ""Cholecalciferol related to chronic obstructive pulmonary disease"" supported by the sentence: ""These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.""?",False, -18889413,Cholecalciferol related to polycystic ovary syndrome,4364,Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?,"Is the triple ""Cholecalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?""?",False, -18830431,Cholecalciferol related to prostate cancer,4365,"Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.","Is the triple ""Cholecalciferol related to prostate cancer"" supported by the sentence: ""Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.""?",False, -18776998,Cholecalciferol related to epilepsy,4366,"These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.","Is the triple ""Cholecalciferol related to epilepsy"" supported by the sentence: ""These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.""?",False, -18009382,Cholecalciferol related to type 1 diabetes mellitus,4367,Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.,"Is the triple ""Cholecalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.""?",False, -17581366,Cholecalciferol related to vitamin D deficiency,4368,The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.,"Is the triple ""Cholecalciferol related to vitamin D deficiency"" supported by the sentence: ""The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.""?",False, -17374616,Cholecalciferol related to type 2 diabetes mellitus,4369,METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.,"Is the triple ""Cholecalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.""?",False, -17169513,Cholecalciferol related to Parkinson disease,4370,CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.,"Is the triple ""Cholecalciferol related to Parkinson disease"" supported by the sentence: ""CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.""?",False, -17054911,Cholecalciferol related to tuberculosis,4371,Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.,"Is the triple ""Cholecalciferol related to tuberculosis"" supported by the sentence: ""Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.""?",False, -16909919,Cholecalciferol related to inflammatory bowel disease,4372,Vitamin D3 has been considered a viable adjunctive therapy in IBD.,"Is the triple ""Cholecalciferol related to inflammatory bowel disease"" supported by the sentence: ""Vitamin D3 has been considered a viable adjunctive therapy in IBD.""?",False, -16219443,"Cholecalciferol related to dermatitis, atopic",4373,Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.,"Is the triple ""Cholecalciferol related to dermatitis, atopic"" supported by the sentence: ""Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.""?",False, -16115730,Cholecalciferol related to cardiovascular disorder,4374,Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.,"Is the triple ""Cholecalciferol related to cardiovascular disorder"" supported by the sentence: ""Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.""?",False, -15133291,Cholecalciferol related to Marchiafava-Bignami disease,4375,"Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.","Is the triple ""Cholecalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.""?",False, -14512631,Cholecalciferol related to hyperparathyroidism,4376,Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.,"Is the triple ""Cholecalciferol related to hyperparathyroidism"" supported by the sentence: ""Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.""?",False, -13680137,Cholecalciferol related to multiple sclerosis,4377,"Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.","Is the triple ""Cholecalciferol related to multiple sclerosis"" supported by the sentence: ""Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.""?",False, -13562951,Cholecalciferol related to metabolic syndrome X,4378,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to metabolic syndrome X"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, -13562949,Cholecalciferol related to obesity disorder,4379,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to obesity disorder"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, -13035326,Cholecalciferol related to bone fracture,4380,Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.,"Is the triple ""Cholecalciferol related to bone fracture"" supported by the sentence: ""Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.""?",False, -11935565,Cholecalciferol related to osteoporosis,4381,"The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.","Is the triple ""Cholecalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.""?",False, -11152529,Cholecalciferol related to diabetes mellitus,4382,"Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.","Is the triple ""Cholecalciferol related to diabetes mellitus"" supported by the sentence: ""Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.""?",False, -10386853,Cholecalciferol related to Crohn disease,4383,OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.,"Is the triple ""Cholecalciferol related to Crohn disease"" supported by the sentence: ""OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.""?",False, -9703967,Cholecalciferol related to melanoma,4384,"As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.","Is the triple ""Cholecalciferol related to melanoma"" supported by the sentence: ""As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.""?",False, -9414232,Cholecalciferol related to psoriasis,4385,Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.,"Is the triple ""Cholecalciferol related to psoriasis"" supported by the sentence: ""Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.""?",False, -8798994,Cholecalciferol related to hip fracture,4386,"Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.","Is the triple ""Cholecalciferol related to hip fracture"" supported by the sentence: ""Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.""?",False, -20878953,Cholecalciferol causes polycystic ovary syndrome,4387,"Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.","Is the triple ""Cholecalciferol causes polycystic ovary syndrome"" supported by the sentence: ""Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.""?",False, -20469671,Cholecalciferol causes tuberculosis,4388,Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.,"Is the triple ""Cholecalciferol causes tuberculosis"" supported by the sentence: ""Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.""?",False, -20417553,Cholecalciferol causes psoriasis,4389,There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.,"Is the triple ""Cholecalciferol causes psoriasis"" supported by the sentence: ""There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.""?",False, -19411734,"Cholecalciferol causes dermatitis, atopic",4390,"In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.","Is the triple ""Cholecalciferol causes dermatitis, atopic"" supported by the sentence: ""In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.""?",False, -17854537,Cholecalciferol causes neoplasm,4391,"Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.","Is the triple ""Cholecalciferol causes neoplasm"" supported by the sentence: ""Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.""?",False, -15944158,Cholecalciferol causes vitamin D deficiency,4392,"Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.","Is the triple ""Cholecalciferol causes vitamin D deficiency"" supported by the sentence: ""Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.""?",False, -13998286,Cholecalciferol causes depressive disorder,4393,"Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.","Is the triple ""Cholecalciferol causes depressive disorder"" supported by the sentence: ""Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.""?",False, -27560876,Cholecalciferol affects prostate cancer,4394,Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.,"Is the triple ""Cholecalciferol affects prostate cancer"" supported by the sentence: ""Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.""?",False, -22640117,Cholecalciferol affects severe acute respiratory syndrome,4395,Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?,"Is the triple ""Cholecalciferol affects severe acute respiratory syndrome"" supported by the sentence: ""Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?""?",False, -21843529,Cholecalciferol affects Pregnancy,4396,"Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.""?",False, -21703950,Cholecalciferol affects Marchiafava-Bignami disease,4397,"VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.","Is the triple ""Cholecalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.""?",False, -20945952,Cholecalciferol affects type 2 diabetes mellitus,4398,Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.,"Is the triple ""Cholecalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.""?",False, -20733345,Cholecalciferol affects epilepsy,4399,"Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.","Is the triple ""Cholecalciferol affects epilepsy"" supported by the sentence: ""Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.""?",False, -20612106,Cholecalciferol affects Cognitive impairment,4400,Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.,"Is the triple ""Cholecalciferol affects Cognitive impairment"" supported by the sentence: ""Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.""?",False, -19925618,Cholecalciferol affects asthma,4401,"METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.","Is the triple ""Cholecalciferol affects asthma"" supported by the sentence: ""METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.""?",False, -19815601,Cholecalciferol affects ulcerative colitis,4402,The effect of vitamin D3 on UC disease activity is still unclear.,"Is the triple ""Cholecalciferol affects ulcerative colitis"" supported by the sentence: ""The effect of vitamin D3 on UC disease activity is still unclear.""?",False, -19556148,Cholecalciferol affects neoplasm,4403,"In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.""?",False, -19132727,Cholecalciferol affects obesity disorder,4404,Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.,"Is the triple ""Cholecalciferol affects obesity disorder"" supported by the sentence: ""Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.""?",False, -18122364,Cholecalciferol affects metabolic syndrome X,4405,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects metabolic syndrome X"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, -18122363,Cholecalciferol affects cardiovascular disorder,4406,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects cardiovascular disorder"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, -17715748,Cholecalciferol affects hip fracture,4407,"Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.","Is the triple ""Cholecalciferol affects hip fracture"" supported by the sentence: ""Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.""?",False, -17674517,Cholecalciferol affects Pregnancy,4408,"OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.""?",False, -17585577,Cholecalciferol affects depressive disorder,4409,"It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.","Is the triple ""Cholecalciferol affects depressive disorder"" supported by the sentence: ""It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.""?",False, -17451551,Cholecalciferol affects neoplasm,4410,"Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.""?",False, -16299943,Cholecalciferol affects polycystic ovary syndrome,4411,"The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).","Is the triple ""Cholecalciferol affects polycystic ovary syndrome"" supported by the sentence: ""The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).""?",False, -16007821,Cholecalciferol affects psoriasis,4412,Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.,"Is the triple ""Cholecalciferol affects psoriasis"" supported by the sentence: ""Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.""?",False, -15977971,Cholecalciferol affects melanoma,4413,"CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.","Is the triple ""Cholecalciferol affects melanoma"" supported by the sentence: ""CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.""?",False, -15944152,Cholecalciferol affects osteoporosis,4414,[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].,"Is the triple ""Cholecalciferol affects osteoporosis"" supported by the sentence: ""[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].""?",False, -15393278,Cholecalciferol affects chronic obstructive pulmonary disease,4415,"Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.","Is the triple ""Cholecalciferol affects chronic obstructive pulmonary disease"" supported by the sentence: ""Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.""?",False, -15170889,Cholecalciferol affects multiple sclerosis,4416,The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.,"Is the triple ""Cholecalciferol affects multiple sclerosis"" supported by the sentence: ""The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.""?",False, -13518388,Cholecalciferol affects bone fracture,4417,[Latest evidence on the suppressive effect of active vitamin D3 on fractures].,"Is the triple ""Cholecalciferol affects bone fracture"" supported by the sentence: ""[Latest evidence on the suppressive effect of active vitamin D3 on fractures].""?",False, -21045274,Cholecalciferol produces Marchiafava-Bignami disease,4418,"CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.","Is the triple ""Cholecalciferol produces Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.""?",False, -17840044,Cholecalciferol produces inflammatory bowel disease,4419,"The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.","Is the triple ""Cholecalciferol produces inflammatory bowel disease"" supported by the sentence: ""The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.""?",False, -20733344,Cholecalciferol disrupts epilepsy,4420,Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.,"Is the triple ""Cholecalciferol disrupts epilepsy"" supported by the sentence: ""Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.""?",False, -19044664,Cholecalciferol disrupts AIDS,4421,Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.,"Is the triple ""Cholecalciferol disrupts AIDS"" supported by the sentence: ""Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.""?",False, -15558469,Cholecalciferol disrupts HIV infectious disease,4422,"Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.","Is the triple ""Cholecalciferol disrupts HIV infectious disease"" supported by the sentence: ""Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.""?",False, -14834931,Cholecalciferol disrupts neoplasm,4423,"Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.","Is the triple ""Cholecalciferol disrupts neoplasm"" supported by the sentence: ""Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.""?",False, -14617748,Cholecalciferol disrupts multiple sclerosis,4424,"Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.","Is the triple ""Cholecalciferol disrupts multiple sclerosis"" supported by the sentence: ""Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.""?",False, -14491908,Cholecalciferol disrupts vitamin D deficiency,4425,"Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.","Is the triple ""Cholecalciferol disrupts vitamin D deficiency"" supported by the sentence: ""Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.""?",False, -11194374,Cholecalciferol disrupts Marchiafava-Bignami disease,4426,Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.,"Is the triple ""Cholecalciferol disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.""?",False, -25419746,Cholecalciferol prevents Infection,4427,This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.,"Is the triple ""Cholecalciferol prevents Infection"" supported by the sentence: ""This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.""?",False, -23552226,Cholecalciferol prevents type 1 diabetes mellitus,4428,Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?,"Is the triple ""Cholecalciferol prevents type 1 diabetes mellitus"" supported by the sentence: ""Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?""?",False, -23324302,Cholecalciferol prevents ulcerative colitis,4429,CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.,"Is the triple ""Cholecalciferol prevents ulcerative colitis"" supported by the sentence: ""CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.""?",False, -22418643,Cholecalciferol prevents chronic obstructive pulmonary disease,4430,"MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).","Is the triple ""Cholecalciferol prevents chronic obstructive pulmonary disease"" supported by the sentence: ""MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).""?",False, -22340834,Cholecalciferol prevents depressive disorder,4431,These findings do not support the use of vitamin D3 in adults to prevent depression.,"Is the triple ""Cholecalciferol prevents depressive disorder"" supported by the sentence: ""These findings do not support the use of vitamin D3 in adults to prevent depression.""?",False, -20959064,Cholecalciferol prevents postmenopausal osteoporosis,4432,"Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?","Is the triple ""Cholecalciferol prevents postmenopausal osteoporosis"" supported by the sentence: ""Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?""?",False, -20699168,Cholecalciferol prevents cardiovascular disorder,4433,"Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.","Is the triple ""Cholecalciferol prevents cardiovascular disorder"" supported by the sentence: ""Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.""?",False, -19389521,Cholecalciferol prevents epilepsy,4434,"Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.","Is the triple ""Cholecalciferol prevents epilepsy"" supported by the sentence: ""Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.""?",False, -18282049,Cholecalciferol prevents inherited lipid metabolism disorder,4435,"Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.","Is the triple ""Cholecalciferol prevents inherited lipid metabolism disorder"" supported by the sentence: ""Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.""?",False, -17951280,Cholecalciferol prevents anemia,4436,VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.,"Is the triple ""Cholecalciferol prevents anemia"" supported by the sentence: ""VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.""?",False, -17701830,Cholecalciferol prevents influenza,4437,[Does vitamin D3 fail to protect against influenza after all?].,"Is the triple ""Cholecalciferol prevents influenza"" supported by the sentence: ""[Does vitamin D3 fail to protect against influenza after all?].""?",False, -15773595,Cholecalciferol prevents neoplasm,4438,[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].,"Is the triple ""Cholecalciferol prevents neoplasm"" supported by the sentence: ""[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].""?",False, -15663430,Cholecalciferol prevents diabetes mellitus,4439,"There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.","Is the triple ""Cholecalciferol prevents diabetes mellitus"" supported by the sentence: ""There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.""?",False, -12943427,Cholecalciferol prevents vitamin D deficiency,4440,"The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.","Is the triple ""Cholecalciferol prevents vitamin D deficiency"" supported by the sentence: ""The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.""?",False, -11194373,Cholecalciferol prevents osteoporosis,4441,"The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.","Is the triple ""Cholecalciferol prevents osteoporosis"" supported by the sentence: ""The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.""?",False, -11017561,Cholecalciferol prevents Marchiafava-Bignami disease,4442,Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.,"Is the triple ""Cholecalciferol prevents Marchiafava-Bignami disease"" supported by the sentence: ""Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.""?",False, -10503621,Cholecalciferol prevents bone fracture,4443,CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.,"Is the triple ""Cholecalciferol prevents bone fracture"" supported by the sentence: ""CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.""?",False, -9458588,Cholecalciferol prevents hip fracture,4444,We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.,"Is the triple ""Cholecalciferol prevents hip fracture"" supported by the sentence: ""We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.""?",False, -21072124,Cholecalciferol predisposes metabolic syndrome X,4445,"Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.","Is the triple ""Cholecalciferol predisposes metabolic syndrome X"" supported by the sentence: ""Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.""?",False, -18104348,Cholecalciferol predisposes colorectal neoplasm,4446,These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.,"Is the triple ""Cholecalciferol predisposes colorectal neoplasm"" supported by the sentence: ""These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.""?",False, -17901013,Cholecalciferol predisposes bone fracture,4447,"Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.","Is the triple ""Cholecalciferol predisposes bone fracture"" supported by the sentence: ""Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.""?",False, -17714481,Cholecalciferol predisposes asthma,4448,"Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.","Is the triple ""Cholecalciferol predisposes asthma"" supported by the sentence: ""Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.""?",False, -17184810,Cholecalciferol predisposes multiple sclerosis,4449,"There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.","Is the triple ""Cholecalciferol predisposes multiple sclerosis"" supported by the sentence: ""There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.""?",False, -15110409,Cholecalciferol predisposes vitamin D deficiency,4450,Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.,"Is the triple ""Cholecalciferol predisposes vitamin D deficiency"" supported by the sentence: ""Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.""?",False, -13562954,Cholecalciferol predisposes type 2 diabetes mellitus,4451,"In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.","Is the triple ""Cholecalciferol predisposes type 2 diabetes mellitus"" supported by the sentence: ""In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.""?",False, -9524358,Cholecalciferol predisposes hip fracture,4452,"Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.","Is the triple ""Cholecalciferol predisposes hip fracture"" supported by the sentence: ""Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.""?",False, -9314384,Cholecalciferol predisposes Marchiafava-Bignami disease,4453,"Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.","Is the triple ""Cholecalciferol predisposes Marchiafava-Bignami disease"" supported by the sentence: ""Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.""?",False, -27330803,Ergocalciferol related to Familial hypophosphatemia,4454,Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.,"Is the triple ""Ergocalciferol related to Familial hypophosphatemia"" supported by the sentence: ""Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.""?",False, -26089502,Ergocalciferol related to osteogenesis imperfecta,4455,Vitamin D and related research in osteogenesis imperfecta.,"Is the triple ""Ergocalciferol related to osteogenesis imperfecta"" supported by the sentence: ""Vitamin D and related research in osteogenesis imperfecta.""?",False, -22199149,Ergocalciferol related to Hypocalcemia,4456,Hypocalcemia may be associated with imbalanced VD and PTH levels.,"Is the triple ""Ergocalciferol related to Hypocalcemia"" supported by the sentence: ""Hypocalcemia may be associated with imbalanced VD and PTH levels.""?",False, -22194600,Ergocalciferol related to severe acute respiratory syndrome,4457,"Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.","Is the triple ""Ergocalciferol related to severe acute respiratory syndrome"" supported by the sentence: ""Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.""?",False, -21840711,Ergocalciferol related to castration-resistant prostate carcinoma,4458,"Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.","Is the triple ""Ergocalciferol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.""?",False, -21543726,Ergocalciferol related to sarcopenia,4459,"Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.","Is the triple ""Ergocalciferol related to sarcopenia"" supported by the sentence: ""Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.""?",False, -21516783,Ergocalciferol related to non-alcoholic fatty liver disease,4460,"Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.","Is the triple ""Ergocalciferol related to non-alcoholic fatty liver disease"" supported by the sentence: ""Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.""?",False, -21478252,Ergocalciferol related to bone fracture,4461,"Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.","Is the triple ""Ergocalciferol related to bone fracture"" supported by the sentence: ""Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.""?",False, -21128214,Ergocalciferol related to bone Paget disease,4462,Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.,"Is the triple ""Ergocalciferol related to bone Paget disease"" supported by the sentence: ""Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.""?",False, -20256197,Ergocalciferol related to restless legs syndrome,4463,"After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).","Is the triple ""Ergocalciferol related to restless legs syndrome"" supported by the sentence: ""After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).""?",False, -19853448,Ergocalciferol related to neuralgia,4464,This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.,"Is the triple ""Ergocalciferol related to neuralgia"" supported by the sentence: ""This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.""?",False, -19595978,Ergocalciferol related to hepatitis C virus infection,4465,BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.,"Is the triple ""Ergocalciferol related to hepatitis C virus infection"" supported by the sentence: ""BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.""?",False, -19221334,Ergocalciferol related to spinal cord injury,4466,"Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.","Is the triple ""Ergocalciferol related to spinal cord injury"" supported by the sentence: ""Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.""?",False, -18303138,Ergocalciferol related to optic neuritis,4467,"The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.","Is the triple ""Ergocalciferol related to optic neuritis"" supported by the sentence: ""The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.""?",False, -17457750,Ergocalciferol related to migraine disorder,4468,"CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.","Is the triple ""Ergocalciferol related to migraine disorder"" supported by the sentence: ""CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.""?",False, -17248671,Ergocalciferol related to diffuse alopecia areata,4469,"There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.","Is the triple ""Ergocalciferol related to diffuse alopecia areata"" supported by the sentence: ""There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.""?",False, -16231683,Ergocalciferol related to chronic hepatitis C virus infection,4470,Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.,"Is the triple ""Ergocalciferol related to chronic hepatitis C virus infection"" supported by the sentence: ""Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.""?",False, -16050991,Ergocalciferol related to lung neoplasm,4471,"In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.","Is the triple ""Ergocalciferol related to lung neoplasm"" supported by the sentence: ""In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.""?",False, -15954794,Ergocalciferol related to femoral neck fracture,4472,Spontaneous femoral neck fracture associated with a low serum level of vitamin D.,"Is the triple ""Ergocalciferol related to femoral neck fracture"" supported by the sentence: ""Spontaneous femoral neck fracture associated with a low serum level of vitamin D.""?",False, -15739454,Ergocalciferol related to diabetic neuropathy,4473,Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.,"Is the triple ""Ergocalciferol related to diabetic neuropathy"" supported by the sentence: ""Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.""?",False, -15603622,Ergocalciferol related to HIV infectious disease,4474,Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.,"Is the triple ""Ergocalciferol related to HIV infectious disease"" supported by the sentence: ""Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.""?",False, -15306422,Ergocalciferol related to blood coagulation disease,4475,"Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.","Is the triple ""Ergocalciferol related to blood coagulation disease"" supported by the sentence: ""Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.""?",False, -15165807,Ergocalciferol related to postmenopausal osteoporosis,4476,Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.,"Is the triple ""Ergocalciferol related to postmenopausal osteoporosis"" supported by the sentence: ""Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.""?",False, -14949967,Ergocalciferol related to Premature birth,4477,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to Premature birth"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, -14949966,Ergocalciferol related to gestational diabetes,4478,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to gestational diabetes"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, -14870236,Ergocalciferol related to chronic renal failure syndrome,4479,[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].,"Is the triple ""Ergocalciferol related to chronic renal failure syndrome"" supported by the sentence: ""[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].""?",False, -14594285,Ergocalciferol related to colorectal neoplasm,4480,"Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.","Is the triple ""Ergocalciferol related to colorectal neoplasm"" supported by the sentence: ""Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.""?",False, -14321159,Ergocalciferol related to asthma,4481,"Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.","Is the triple ""Ergocalciferol related to asthma"" supported by the sentence: ""Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.""?",False, -13975664,Ergocalciferol related to cutaneous lupus erythematosus,4482,Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.,"Is the triple ""Ergocalciferol related to cutaneous lupus erythematosus"" supported by the sentence: ""Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.""?",False, -13939480,Ergocalciferol related to mood disorder,4483,This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.,"Is the triple ""Ergocalciferol related to mood disorder"" supported by the sentence: ""This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.""?",False, -13895667,Ergocalciferol related to sudden cardiac arrest,4484,OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).,"Is the triple ""Ergocalciferol related to sudden cardiac arrest"" supported by the sentence: ""OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).""?",False, -13383363,Ergocalciferol related to sickle cell anemia,4485,The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.,"Is the triple ""Ergocalciferol related to sickle cell anemia"" supported by the sentence: ""The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.""?",False, -13199782,Ergocalciferol related to Alzheimer disease,4486,"Consequently, this study provides evidence for a possible link between AD and vitamin D.","Is the triple ""Ergocalciferol related to Alzheimer disease"" supported by the sentence: ""Consequently, this study provides evidence for a possible link between AD and vitamin D.""?",False, -12834035,Ergocalciferol related to inflammatory bowel disease,4487,Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.,"Is the triple ""Ergocalciferol related to inflammatory bowel disease"" supported by the sentence: ""Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.""?",False, -12803681,Ergocalciferol related to Insulin resistance,4488,We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.,"Is the triple ""Ergocalciferol related to Insulin resistance"" supported by the sentence: ""We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.""?",False, -12377378,Ergocalciferol related to non-Hodgkin lymphoma,4489,CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.,"Is the triple ""Ergocalciferol related to non-Hodgkin lymphoma"" supported by the sentence: ""CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.""?",False, -12131992,Ergocalciferol related to primary hyperparathyroidism,4490,"Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.","Is the triple ""Ergocalciferol related to primary hyperparathyroidism"" supported by the sentence: ""Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.""?",False, -11979233,Ergocalciferol related to leukemia,4491,Vitamin D compounds in leukemia.,"Is the triple ""Ergocalciferol related to leukemia"" supported by the sentence: ""Vitamin D compounds in leukemia.""?",False, -11933002,Ergocalciferol related to Pain,4492,"CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.","Is the triple ""Ergocalciferol related to Pain"" supported by the sentence: ""CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.""?",False, -11653558,Ergocalciferol related to melanoma,4493,The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.,"Is the triple ""Ergocalciferol related to melanoma"" supported by the sentence: ""The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.""?",False, -11434397,Ergocalciferol related to type 1 diabetes mellitus,4494,"Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.","Is the triple ""Ergocalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.""?",False, -11002964,Ergocalciferol related to pulmonary tuberculosis,4495,[Effect of vitamin D2 in pulmonary tuberculosis].,"Is the triple ""Ergocalciferol related to pulmonary tuberculosis"" supported by the sentence: ""[Effect of vitamin D2 in pulmonary tuberculosis].""?",False, -10894479,Ergocalciferol related to Crohn disease,4496,"A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.","Is the triple ""Ergocalciferol related to Crohn disease"" supported by the sentence: ""A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.""?",False, -10768947,Ergocalciferol related to hip fracture,4497,BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.,"Is the triple ""Ergocalciferol related to hip fracture"" supported by the sentence: ""BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.""?",False, -10183383,Ergocalciferol related to Marchiafava-Bignami disease,4498,"Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.","Is the triple ""Ergocalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.""?",False, -10168534,Ergocalciferol related to tuberculosis,4499,"Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.","Is the triple ""Ergocalciferol related to tuberculosis"" supported by the sentence: ""Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.""?",False, -10066878,Ergocalciferol related to lymphoma,4500,"However, the cellular source of the vitamin D hormone in lymphomas remains unclear.","Is the triple ""Ergocalciferol related to lymphoma"" supported by the sentence: ""However, the cellular source of the vitamin D hormone in lymphomas remains unclear.""?",False, -9770434,Ergocalciferol related to neoplasm,4501,"On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.","Is the triple ""Ergocalciferol related to neoplasm"" supported by the sentence: ""On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.""?",False, -9499640,Ergocalciferol related to hypoparathyroidism,4502,The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.,"Is the triple ""Ergocalciferol related to hypoparathyroidism"" supported by the sentence: ""The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.""?",False, -9487308,Ergocalciferol related to myocardial ischemia,4503,Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).,"Is the triple ""Ergocalciferol related to myocardial ischemia"" supported by the sentence: ""Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).""?",False, -9462983,Ergocalciferol related to ulcerative colitis,4504,Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.,"Is the triple ""Ergocalciferol related to ulcerative colitis"" supported by the sentence: ""Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.""?",False, -9176947,Ergocalciferol related to psoriasis,4505,[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].,"Is the triple ""Ergocalciferol related to psoriasis"" supported by the sentence: ""[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].""?",False, -9137351,Ergocalciferol related to nutritional disorder,4506,"RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.","Is the triple ""Ergocalciferol related to nutritional disorder"" supported by the sentence: ""RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.""?",False, -8792180,Ergocalciferol related to type 2 diabetes mellitus,4507,Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.,"Is the triple ""Ergocalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.""?",False, -8116213,Ergocalciferol related to obesity disorder,4508,These data suggest that low vitamin D may be associated with obesity per se.,"Is the triple ""Ergocalciferol related to obesity disorder"" supported by the sentence: ""These data suggest that low vitamin D may be associated with obesity per se.""?",False, -8093753,Ergocalciferol related to vitamin D deficiency,4509,The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.,"Is the triple ""Ergocalciferol related to vitamin D deficiency"" supported by the sentence: ""The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.""?",False, -8061037,Ergocalciferol related to multiple sclerosis,4510,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to multiple sclerosis"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, -8061036,Ergocalciferol related to diabetes mellitus,4511,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to diabetes mellitus"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, -7613246,Ergocalciferol related to osteoporosis,4512,The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.,"Is the triple ""Ergocalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.""?",False, -7587226,Ergocalciferol related to polycystic ovary syndrome,4513,Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.,"Is the triple ""Ergocalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.""?",False, -7252642,Ergocalciferol related to prostate cancer,4514,"Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.","Is the triple ""Ergocalciferol related to prostate cancer"" supported by the sentence: ""Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.""?",False, -26403196,Ergocalciferol causes primary hyperparathyroidism,4515,Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.,"Is the triple ""Ergocalciferol causes primary hyperparathyroidism"" supported by the sentence: ""Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.""?",False, -25624374,Ergocalciferol causes leukemia,4516,Reversibility of vitamin D-induced human leukemia cell-line maturation.,"Is the triple ""Ergocalciferol causes leukemia"" supported by the sentence: ""Reversibility of vitamin D-induced human leukemia cell-line maturation.""?",False, -25513025,Ergocalciferol causes restless legs syndrome,4517,We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.,"Is the triple ""Ergocalciferol causes restless legs syndrome"" supported by the sentence: ""We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.""?",False, -25147512,Ergocalciferol causes sarcopenia,4518,"To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.","Is the triple ""Ergocalciferol causes sarcopenia"" supported by the sentence: ""To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.""?",False, -21420546,Ergocalciferol causes diabetic neuropathy,4519,"Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).","Is the triple ""Ergocalciferol causes diabetic neuropathy"" supported by the sentence: ""Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).""?",False, -21344725,Ergocalciferol causes diffuse alopecia areata,4520,"This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.","Is the triple ""Ergocalciferol causes diffuse alopecia areata"" supported by the sentence: ""This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.""?",False, -19221130,Ergocalciferol causes non-alcoholic fatty liver disease,4521,"Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.","Is the triple ""Ergocalciferol causes non-alcoholic fatty liver disease"" supported by the sentence: ""Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.""?",False, -19022139,Ergocalciferol causes gestational diabetes,4522,BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).,"Is the triple ""Ergocalciferol causes gestational diabetes"" supported by the sentence: ""BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).""?",False, -18967408,Ergocalciferol causes polycystic ovary syndrome,4523,"BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.","Is the triple ""Ergocalciferol causes polycystic ovary syndrome"" supported by the sentence: ""BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.""?",False, -18875338,Ergocalciferol causes psoriasis,4524,"The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.","Is the triple ""Ergocalciferol causes psoriasis"" supported by the sentence: ""The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.""?",False, -18041148,Ergocalciferol causes Crohn disease,4525,"Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.","Is the triple ""Ergocalciferol causes Crohn disease"" supported by the sentence: ""Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.""?",False, -16369420,Ergocalciferol causes neoplasm,4526,"Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.","Is the triple ""Ergocalciferol causes neoplasm"" supported by the sentence: ""Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.""?",False, -16017645,Ergocalciferol causes obesity disorder,4527,This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.,"Is the triple ""Ergocalciferol causes obesity disorder"" supported by the sentence: ""This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.""?",False, -15862130,Ergocalciferol causes type 2 diabetes mellitus,4528,"CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.","Is the triple ""Ergocalciferol causes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.""?",False, -15179909,Ergocalciferol causes asthma,4529,"OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.","Is the triple ""Ergocalciferol causes asthma"" supported by the sentence: ""OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.""?",False, -14594790,Ergocalciferol causes Insulin resistance,4530,"In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.","Is the triple ""Ergocalciferol causes Insulin resistance"" supported by the sentence: ""In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.""?",False, -14004176,Ergocalciferol causes Pain,4531,The independent role of vitamin D in the etiology of pain remains controversial.,"Is the triple ""Ergocalciferol causes Pain"" supported by the sentence: ""The independent role of vitamin D in the etiology of pain remains controversial.""?",False, -12191251,Ergocalciferol causes osteoporosis,4532,"We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.","Is the triple ""Ergocalciferol causes osteoporosis"" supported by the sentence: ""We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.""?",False, -11612180,Ergocalciferol causes colorectal neoplasm,4533,There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.,"Is the triple ""Ergocalciferol causes colorectal neoplasm"" supported by the sentence: ""There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.""?",False, -11557471,Ergocalciferol causes vitamin D deficiency,4534,"Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).","Is the triple ""Ergocalciferol causes vitamin D deficiency"" supported by the sentence: ""Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).""?",False, -11557464,Ergocalciferol causes inflammatory bowel disease,4535,Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.,"Is the triple ""Ergocalciferol causes inflammatory bowel disease"" supported by the sentence: ""Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.""?",False, -11275618,Ergocalciferol causes type 1 diabetes mellitus,4536,These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol causes type 1 diabetes mellitus"" supported by the sentence: ""These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.""?",False, -10362733,Ergocalciferol causes multiple sclerosis,4537,Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.,"Is the triple ""Ergocalciferol causes multiple sclerosis"" supported by the sentence: ""Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.""?",False, -8719466,Ergocalciferol causes diabetes mellitus,4538,"In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).","Is the triple ""Ergocalciferol causes diabetes mellitus"" supported by the sentence: ""In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).""?",False, -8407906,Ergocalciferol causes Marchiafava-Bignami disease,4539,Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.,"Is the triple ""Ergocalciferol causes Marchiafava-Bignami disease"" supported by the sentence: ""Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.""?",False, -7553325,Ergocalciferol causes prostate cancer,4540,"OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).","Is the triple ""Ergocalciferol causes prostate cancer"" supported by the sentence: ""OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).""?",False, -7357695,Ergocalciferol causes bone fracture,4541,Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.,"Is the triple ""Ergocalciferol causes bone fracture"" supported by the sentence: ""Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.""?",False, -25936029,Ergocalciferol affects nutritional disorder,4542,"Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.","Is the triple ""Ergocalciferol affects nutritional disorder"" supported by the sentence: ""Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.""?",False, -25430100,Ergocalciferol affects primary hyperparathyroidism,4543,Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.""?",False, -24682916,Ergocalciferol affects bone fracture,4544,"Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.""?",False, -24133915,Ergocalciferol affects HIV infectious disease,4545,Potential immune modulatory effect of vitamin D in HIV infection: A review.,"Is the triple ""Ergocalciferol affects HIV infectious disease"" supported by the sentence: ""Potential immune modulatory effect of vitamin D in HIV infection: A review.""?",False, -23716846,Ergocalciferol affects Premature birth,4546,Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.""?",False, -22436428,Ergocalciferol affects obesity disorder,4547,Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).,"Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).""?",False, -22382447,Ergocalciferol affects Pregnancy,4548,Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.""?",False, -21132793,Ergocalciferol affects breast neoplasm,4549,"As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.","Is the triple ""Ergocalciferol affects breast neoplasm"" supported by the sentence: ""As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.""?",False, -20959246,Ergocalciferol affects diabetes mellitus,4550,These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.,"Is the triple ""Ergocalciferol affects diabetes mellitus"" supported by the sentence: ""These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.""?",False, -20298561,Ergocalciferol affects inflammatory bowel disease,4551,"We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.","Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.""?",False, -20058982,Ergocalciferol affects gestational diabetes,4552,TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.""?",False, -19907316,Ergocalciferol affects gestational diabetes,4553,This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.""?",False, -19815602,Ergocalciferol affects ulcerative colitis,4554,Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.,"Is the triple ""Ergocalciferol affects ulcerative colitis"" supported by the sentence: ""Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.""?",False, -19320344,Ergocalciferol affects Premature birth,4555,We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.""?",False, -19221129,Ergocalciferol affects non-alcoholic fatty liver disease,4556,"Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.","Is the triple ""Ergocalciferol affects non-alcoholic fatty liver disease"" supported by the sentence: ""Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.""?",False, -18424308,Ergocalciferol affects vitamin D deficiency,4557,Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.,"Is the triple ""Ergocalciferol affects vitamin D deficiency"" supported by the sentence: ""Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.""?",False, -18115621,Ergocalciferol affects asthma,4558,"BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.""?",False, -17654393,Ergocalciferol affects optic neuritis,4559,"CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.","Is the triple ""Ergocalciferol affects optic neuritis"" supported by the sentence: ""CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.""?",False, -17646826,Ergocalciferol affects migraine disorder,4560,"However, the data examining the relation of vitamin D with migraine are limited.","Is the triple ""Ergocalciferol affects migraine disorder"" supported by the sentence: ""However, the data examining the relation of vitamin D with migraine are limited.""?",False, -17581908,Ergocalciferol affects Pain,4561,Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.,"Is the triple ""Ergocalciferol affects Pain"" supported by the sentence: ""Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.""?",False, -17056932,Ergocalciferol affects sarcopenia,4562,"Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.""?",False, -16630786,Ergocalciferol affects sarcopenia,4563,"Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.""?",False, -16542255,Ergocalciferol affects melanoma,4564,"Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.","Is the triple ""Ergocalciferol affects melanoma"" supported by the sentence: ""Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.""?",False, -16343274,Ergocalciferol affects restless legs syndrome,4565,"Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.","Is the triple ""Ergocalciferol affects restless legs syndrome"" supported by the sentence: ""Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.""?",False, -16273798,Ergocalciferol affects Insulin resistance,4566,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, -16273796,Ergocalciferol affects type 2 diabetes mellitus,4567,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, -15812657,Ergocalciferol affects prostate cancer,4568,Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.""?",False, -15750325,Ergocalciferol affects polycystic ovary syndrome,4569,"Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.","Is the triple ""Ergocalciferol affects polycystic ovary syndrome"" supported by the sentence: ""Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.""?",False, -15694248,Ergocalciferol affects mood disorder,4570,"BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.","Is the triple ""Ergocalciferol affects mood disorder"" supported by the sentence: ""BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.""?",False, -15543952,Ergocalciferol affects osteoporosis,4571,"Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.","Is the triple ""Ergocalciferol affects osteoporosis"" supported by the sentence: ""Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.""?",False, -15528071,Ergocalciferol affects Alzheimer disease,4572,These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.,"Is the triple ""Ergocalciferol affects Alzheimer disease"" supported by the sentence: ""These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.""?",False, -15258155,Ergocalciferol affects obesity disorder,4573,"Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.","Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.""?",False, -14609756,Ergocalciferol affects tuberculosis,4574,Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.,"Is the triple ""Ergocalciferol affects tuberculosis"" supported by the sentence: ""Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.""?",False, -14384550,Ergocalciferol affects psoriasis,4575,"CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.","Is the triple ""Ergocalciferol affects psoriasis"" supported by the sentence: ""CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.""?",False, -14233188,Ergocalciferol affects Insulin resistance,4576,The possible correlations of the calciotropic hormones with insulin resistance were also examined.,"Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""The possible correlations of the calciotropic hormones with insulin resistance were also examined.""?",False, -13916047,Ergocalciferol affects hip fracture,4577,"RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).""?",False, -13794313,Ergocalciferol affects multiple sclerosis,4578,"Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.""?",False, -13764162,Ergocalciferol affects type 2 diabetes mellitus,4579,The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.,"Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.""?",False, -13437693,Ergocalciferol affects Crohn disease,4580,These findings suggest that vitD may play a therapeutic role in CD.,"Is the triple ""Ergocalciferol affects Crohn disease"" supported by the sentence: ""These findings suggest that vitD may play a therapeutic role in CD.""?",False, -13211992,Ergocalciferol affects type 1 diabetes mellitus,4581,BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.""?",False, -13015298,Ergocalciferol affects asthma,4582,"Although vitamin D has important immunologic effects, its relation with asthma is unknown.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""Although vitamin D has important immunologic effects, its relation with asthma is unknown.""?",False, -12698804,Ergocalciferol affects chronic renal failure syndrome,4583,[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].,"Is the triple ""Ergocalciferol affects chronic renal failure syndrome"" supported by the sentence: ""[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].""?",False, -12502345,Ergocalciferol affects inflammatory bowel disease,4584,This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.,"Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.""?",False, -12032067,Ergocalciferol affects multiple sclerosis,4585,"If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.""?",False, -11831475,Ergocalciferol affects bone fracture,4586,"BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.""?",False, -10991167,Ergocalciferol affects type 1 diabetes mellitus,4587,CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.""?",False, -10917919,Ergocalciferol affects primary hyperparathyroidism,4588,Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.""?",False, -10608353,Ergocalciferol affects Pregnancy,4589,Effect of overdose of vitamin D2 on pregnancy in the rat.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Effect of overdose of vitamin D2 on pregnancy in the rat.""?",False, -8987937,Ergocalciferol affects hip fracture,4590,"To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.""?",False, -8925552,Ergocalciferol affects prostate cancer,4591,Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.""?",False, -8894668,Ergocalciferol affects Marchiafava-Bignami disease,4592,"However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.","Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.""?",False, -8321224,Ergocalciferol affects neoplasm,4593,Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.,"Is the triple ""Ergocalciferol affects neoplasm"" supported by the sentence: ""Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.""?",False, -7878820,Ergocalciferol affects Marchiafava-Bignami disease,4594,High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.,"Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.""?",False, -21952380,Ergocalciferol produces obesity disorder,4595,"Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.","Is the triple ""Ergocalciferol produces obesity disorder"" supported by the sentence: ""Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.""?",False, -21636964,Ergocalciferol produces asthma,4596,"Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.","Is the triple ""Ergocalciferol produces asthma"" supported by the sentence: ""Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.""?",False, -20636497,Ergocalciferol produces Pregnancy,4597,"Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.","Is the triple ""Ergocalciferol produces Pregnancy"" supported by the sentence: ""Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.""?",False, -20444810,Ergocalciferol produces Alzheimer disease,4598,"Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.","Is the triple ""Ergocalciferol produces Alzheimer disease"" supported by the sentence: ""Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.""?",False, -15318015,Ergocalciferol produces melanoma,4599,"Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.","Is the triple ""Ergocalciferol produces melanoma"" supported by the sentence: ""Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.""?",False, -14384547,Ergocalciferol produces psoriasis,4600,"Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.","Is the triple ""Ergocalciferol produces psoriasis"" supported by the sentence: ""Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.""?",False, \ No newline at end of file +23573980,Methylprednisolone related to pneumonia,501,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,"Is the triple ""Methylprednisolone related to pneumonia"" supported by the sentence: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?",False, +23514846,Methylprednisolone related to carpal tunnel syndrome,502,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,"Is the triple ""Methylprednisolone related to carpal tunnel syndrome"" supported by the sentence: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?",False, +23364897,Methylprednisolone related to West syndrome,503,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,"Is the triple ""Methylprednisolone related to West syndrome"" supported by the sentence: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?",False, +22495910,Methylprednisolone related to myocarditis,504,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,"Is the triple ""Methylprednisolone related to myocarditis"" supported by the sentence: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?",False, +22175056,Methylprednisolone related to myopathy,505,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.","Is the triple ""Methylprednisolone related to myopathy"" supported by the sentence: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?",False, +20879022,Methylprednisolone related to Pain,506,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.","Is the triple ""Methylprednisolone related to Pain"" supported by the sentence: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?",False, +20342058,Methylprednisolone related to chronic progressive multiple sclerosis,507,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,"Is the triple ""Methylprednisolone related to chronic progressive multiple sclerosis"" supported by the sentence: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?",False, +20290784,Methylprednisolone related to membranous glomerulonephritis,508,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,"Is the triple ""Methylprednisolone related to membranous glomerulonephritis"" supported by the sentence: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?",False, +20286711,Methylprednisolone related to neuromyelitis optica,509,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".","Is the triple ""Methylprednisolone related to neuromyelitis optica"" supported by the sentence: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?",False, +19340184,Methylprednisolone related to chronic obstructive pulmonary disease,510,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,"Is the triple ""Methylprednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?",False, +18938435,Methylprednisolone related to graft versus host disease,511,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,"Is the triple ""Methylprednisolone related to graft versus host disease"" supported by the sentence: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?",False, +17333962,Methylprednisolone related to Inflammation,512,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,"Is the triple ""Methylprednisolone related to Inflammation"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?",False, +17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,513,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,"Is the triple ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?",False, +15936572,Methylprednisolone related to endocrine exophthalmos,514,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,"Is the triple ""Methylprednisolone related to endocrine exophthalmos"" supported by the sentence: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?",False, +15072844,Methylprednisolone related to Edema,515,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.","Is the triple ""Methylprednisolone related to Edema"" supported by the sentence: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?",False, +14876749,Methylprednisolone related to osteoarthritis,516,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,"Is the triple ""Methylprednisolone related to osteoarthritis"" supported by the sentence: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?",False, +14399082,Methylprednisolone related to aplastic anemia,517,Long-term results of high-dose methylprednisolone in aplastic anemia.,"Is the triple ""Methylprednisolone related to aplastic anemia"" supported by the sentence: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?",False, +14398237,Methylprednisolone related to IgA glomerulonephritis,518,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.","Is the triple ""Methylprednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?",False, +14278238,"Methylprednisolone related to dermatitis, atopic",519,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.","Is the triple ""Methylprednisolone related to dermatitis, atopic"" supported by the sentence: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?",False, +14166179,Methylprednisolone related to cardiac arrest,520,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.","Is the triple ""Methylprednisolone related to cardiac arrest"" supported by the sentence: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?",False, +12755316,Methylprednisolone related to plasma cell myeloma,521,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,"Is the triple ""Methylprednisolone related to plasma cell myeloma"" supported by the sentence: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?",False, +12183687,Methylprednisolone related to acute lymphoblastic leukemia,522,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,"Is the triple ""Methylprednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?",False, +11720471,Methylprednisolone related to systemic lupus erythematosus,523,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,"Is the triple ""Methylprednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?",False, +10812685,Methylprednisolone related to immunoglobulin a vasculitis,524,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,"Is the triple ""Methylprednisolone related to immunoglobulin a vasculitis"" supported by the sentence: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?",False, +10763477,Methylprednisolone related to ulcerative colitis,525,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,"Is the triple ""Methylprednisolone related to ulcerative colitis"" supported by the sentence: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?",False, +10558884,Methylprednisolone related to lupus nephritis,526,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,"Is the triple ""Methylprednisolone related to lupus nephritis"" supported by the sentence: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?",False, +10130342,Methylprednisolone related to adult acute respiratory distress syndrome,527,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.","Is the triple ""Methylprednisolone related to adult acute respiratory distress syndrome"" supported by the sentence: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?",False, +9229208,Methylprednisolone related to vestibular neuronitis,528,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.","Is the triple ""Methylprednisolone related to vestibular neuronitis"" supported by the sentence: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?",False, +9003326,Methylprednisolone related to systemic sclerosis,529,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,"Is the triple ""Methylprednisolone related to systemic sclerosis"" supported by the sentence: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?",False, +8447481,Methylprednisolone related to rheumatoid arthritis,530,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,"Is the triple ""Methylprednisolone related to rheumatoid arthritis"" supported by the sentence: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?",False, +8282330,Methylprednisolone related to spinal cord injury,531,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.","Is the triple ""Methylprednisolone related to spinal cord injury"" supported by the sentence: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?",False, +7944646,Methylprednisolone related to myasthenia gravis,532,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,"Is the triple ""Methylprednisolone related to myasthenia gravis"" supported by the sentence: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?",False, +7668599,Methylprednisolone related to multiple sclerosis,533,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,"Is the triple ""Methylprednisolone related to multiple sclerosis"" supported by the sentence: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?",False, +7443745,Methylprednisolone related to asthma,534,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.","Is the triple ""Methylprednisolone related to asthma"" supported by the sentence: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?",False, +24973247,Methylprednisolone causes lupus nephritis,535,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.","Is the triple ""Methylprednisolone causes lupus nephritis"" supported by the sentence: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?",False, +24161886,Methylprednisolone causes Edema,536,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,"Is the triple ""Methylprednisolone causes Edema"" supported by the sentence: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?",False, +18534953,Methylprednisolone causes Inflammation,537,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.","Is the triple ""Methylprednisolone causes Inflammation"" supported by the sentence: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?",False, +18260665,Methylprednisolone causes neoplasm,538,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,"Is the triple ""Methylprednisolone causes neoplasm"" supported by the sentence: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?",False, +17307095,Methylprednisolone causes pneumonia,539,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.","Is the triple ""Methylprednisolone causes pneumonia"" supported by the sentence: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?",False, +15906641,Methylprednisolone causes Pain,540,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,"Is the triple ""Methylprednisolone causes Pain"" supported by the sentence: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?",False, +13166073,Methylprednisolone causes thrombocytopenia,541,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.","Is the triple ""Methylprednisolone causes thrombocytopenia"" supported by the sentence: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?",False, +12672767,Methylprednisolone causes drug-induced liver injury,542,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.","Is the triple ""Methylprednisolone causes drug-induced liver injury"" supported by the sentence: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?",False, +8525599,Methylprednisolone causes myopathy,543,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.","Is the triple ""Methylprednisolone causes myopathy"" supported by the sentence: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?",False, +27357949,Methylprednisolone affects neoplasm,544,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.","Is the triple ""Methylprednisolone affects neoplasm"" supported by the sentence: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?",False, +24420470,Methylprednisolone affects Inflammation,545,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.","Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?",False, +23472756,Methylprednisolone affects Inflammation,546,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,"Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?",False, +20530617,Methylprednisolone affects systemic sclerosis,547,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.","Is the triple ""Methylprednisolone affects systemic sclerosis"" supported by the sentence: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?",False, +20254789,Methylprednisolone affects adult acute respiratory distress syndrome,548,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.","Is the triple ""Methylprednisolone affects adult acute respiratory distress syndrome"" supported by the sentence: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?",False, +17649050,Methylprednisolone affects optic nerve disorder,549,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,"Is the triple ""Methylprednisolone affects optic nerve disorder"" supported by the sentence: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?",False, +16634377,Methylprednisolone affects myasthenia gravis,550,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,"Is the triple ""Methylprednisolone affects myasthenia gravis"" supported by the sentence: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?",False, +16277488,Methylprednisolone affects neuromyelitis optica,551,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,"Is the triple ""Methylprednisolone affects neuromyelitis optica"" supported by the sentence: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?",False, +15906642,Methylprednisolone affects Pain,552,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?",False, +15610554,Methylprednisolone affects rheumatoid arthritis,553,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,"Is the triple ""Methylprednisolone affects rheumatoid arthritis"" supported by the sentence: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?",False, +15186368,Methylprednisolone affects graft versus host disease,554,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,"Is the triple ""Methylprednisolone affects graft versus host disease"" supported by the sentence: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?",False, +14891106,Methylprednisolone affects kidney disorder,555,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.","Is the triple ""Methylprednisolone affects kidney disorder"" supported by the sentence: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?",False, +11819955,Methylprednisolone affects spinal cord injury,556,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.","Is the triple ""Methylprednisolone affects spinal cord injury"" supported by the sentence: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?",False, +10845505,Methylprednisolone affects Pain,557,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?",False, +10048898,Methylprednisolone affects ulcerative colitis,558,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,"Is the triple ""Methylprednisolone affects ulcerative colitis"" supported by the sentence: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?",False, +9646753,Methylprednisolone affects multiple sclerosis,559,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,"Is the triple ""Methylprednisolone affects multiple sclerosis"" supported by the sentence: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?",False, +9346353,Methylprednisolone affects chronic obstructive pulmonary disease,560,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).","Is the triple ""Methylprednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?",False, +9107378,Methylprednisolone affects Edema,561,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.","Is the triple ""Methylprednisolone affects Edema"" supported by the sentence: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?",False, +8596544,Methylprednisolone affects asthma,562,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,"Is the triple ""Methylprednisolone affects asthma"" supported by the sentence: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?",False, +8330909,Methylprednisolone affects systemic lupus erythematosus,563,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,"Is the triple ""Methylprednisolone affects systemic lupus erythematosus"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?",False, +19744632,Methylprednisolone disrupts Edema,564,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.","Is the triple ""Methylprednisolone disrupts Edema"" supported by the sentence: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?",False, +18407557,Methylprednisolone disrupts thrombocytopenia,565,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,"Is the triple ""Methylprednisolone disrupts thrombocytopenia"" supported by the sentence: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?",False, +11106658,Methylprednisolone disrupts Pain,566,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.","Is the triple ""Methylprednisolone disrupts Pain"" supported by the sentence: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?",False, +8640603,Methylprednisolone disrupts Inflammation,567,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,"Is the triple ""Methylprednisolone disrupts Inflammation"" supported by the sentence: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?",False, +23934495,Methylprednisolone prevents Cognitive impairment,568,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.","Is the triple ""Methylprednisolone prevents Cognitive impairment"" supported by the sentence: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?",False, +20014108,Methylprednisolone prevents rheumatoid arthritis,569,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).","Is the triple ""Methylprednisolone prevents rheumatoid arthritis"" supported by the sentence: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?",False, +18266414,Methylprednisolone prevents Abdominal pain,570,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,"Is the triple ""Methylprednisolone prevents Abdominal pain"" supported by the sentence: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?",False, +14967074,Methylprednisolone prevents asthma,571,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,"Is the triple ""Methylprednisolone prevents asthma"" supported by the sentence: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?",False, +9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,572,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,"Is the triple ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?",False, +8345063,Methylprednisolone prevents Pain,573,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.","Is the triple ""Methylprednisolone prevents Pain"" supported by the sentence: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?",False, +8291272,Methylprednisolone prevents graft versus host disease,574,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,"Is the triple ""Methylprednisolone prevents graft versus host disease"" supported by the sentence: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?",False, +7980138,Methylprednisolone prevents spinal cord injury,575,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.","Is the triple ""Methylprednisolone prevents spinal cord injury"" supported by the sentence: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?",False, +7414405,Methylprednisolone prevents Edema,576,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.","Is the triple ""Methylprednisolone prevents Edema"" supported by the sentence: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?",False, +18106042,Methylprednisolone predisposes pneumonia,577,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,"Is the triple ""Methylprednisolone predisposes pneumonia"" supported by the sentence: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?",False, +9645180,Methylprednisolone predisposes Inflammation,578,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.","Is the triple ""Methylprednisolone predisposes Inflammation"" supported by the sentence: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?",False, +12905337,Cefotaxime related to Sepsis,579,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.","Is the triple ""Cefotaxime related to Sepsis"" supported by the sentence: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?",False, +24475300,Cefotaxime affects bacterial infectious disease,580,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.","Is the triple ""Cefotaxime affects bacterial infectious disease"" supported by the sentence: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?",False, +23922029,Cefotaxime affects Sepsis,581,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).","Is the triple ""Cefotaxime affects Sepsis"" supported by the sentence: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?",False, +18672205,Cefotaxime affects peritonitis,582,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.","Is the triple ""Cefotaxime affects peritonitis"" supported by the sentence: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?",False, +15853591,Cefotaxime prevents Sepsis,583,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.","Is the triple ""Cefotaxime prevents Sepsis"" supported by the sentence: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?",False, +19081412,Ceftriaxone prevents bacterial infectious disease,584,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.","Is the triple ""Ceftriaxone prevents bacterial infectious disease"" supported by the sentence: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?",False, +25827448,Gefarnate related to gastric ulcer,585,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,"Is the triple ""Gefarnate related to gastric ulcer"" supported by the sentence: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?",False, +24296137,Gefarnate related to duodenal ulcer,586,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,"Is the triple ""Gefarnate related to duodenal ulcer"" supported by the sentence: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?",False, +25993651,Gefarnate disrupts gastric ulcer,587,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,"Is the triple ""Gefarnate disrupts gastric ulcer"" supported by the sentence: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?",False, +17758516,Neobiotic related to Inflammation,588,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,"Is the triple ""Neobiotic related to Inflammation"" supported by the sentence: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?",False, +10690423,Neobiotic related to burn,589,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,"Is the triple ""Neobiotic related to burn"" supported by the sentence: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?",False, +20263460,Neobiotic affects neoplasm,590,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.","Is the triple ""Neobiotic affects neoplasm"" supported by the sentence: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?",False, +19744068,Neobiotic affects Inflammation,591,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,"Is the triple ""Neobiotic affects Inflammation"" supported by the sentence: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?",False, +24669492,Neobiotic disrupts bacterial infectious disease,592,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.","Is the triple ""Neobiotic disrupts bacterial infectious disease"" supported by the sentence: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?",False, +17119153,Neobiotic disrupts neoplasm,593,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,"Is the triple ""Neobiotic disrupts neoplasm"" supported by the sentence: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?",False, +26428369,Neobiotic prevents bacterial infectious disease,594,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Neobiotic prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, +25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,595,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,"Is the triple ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" supported by the sentence: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?",False, +22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,596,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.","Is the triple ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?",False, +21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,597,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,"Is the triple ""BLINATUMOMAB related to acute lymphoblastic leukemia"" supported by the sentence: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?",False, +27155094,Ciprofloxacin related to endophthalmitis,598,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,"Is the triple ""Ciprofloxacin related to endophthalmitis"" supported by the sentence: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?",False, +16836665,Ciprofloxacin related to Crohn disease,599,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,"Is the triple ""Ciprofloxacin related to Crohn disease"" supported by the sentence: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?",False, +19572117,Ciprofloxacin related to DNA Gyrase,600,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, +19572117,Ciprofloxacin related to DNA Gyrase,601,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, +12385742,Ciprofloxacin coexists with DNA Gyrase,602,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, +12385742,Ciprofloxacin coexists with DNA Gyrase,603,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, +17007621,Ciprofloxacin coexists with DNA Gyrase,604,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, +17007621,Ciprofloxacin coexists with DNA Gyrase,605,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, +9387116,Ciprofloxacin physically interacts with DNA Gyrase,606,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.","Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.""?",False, +8212496,Ciprofloxacin physically interacts with DNA Gyrase,607,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,"Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.""?",False, +25648466,Ciprofloxacin causes abscess,608,Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.,"Is the triple ""Ciprofloxacin causes abscess"" supported by the sentence: ""Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.""?",False, +24716241,Ciprofloxacin causes peritonitis,609,The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.,"Is the triple ""Ciprofloxacin causes peritonitis"" supported by the sentence: ""The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.""?",False, +17154464,Ciprofloxacin causes prostatitis,610,"After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).","Is the triple ""Ciprofloxacin causes prostatitis"" supported by the sentence: ""After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).""?",False, +14369807,Ciprofloxacin causes neutropenia,611,[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].,"Is the triple ""Ciprofloxacin causes neutropenia"" supported by the sentence: ""[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].""?",False, +13950319,Ciprofloxacin causes pneumonia,612,"According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.","Is the triple ""Ciprofloxacin causes pneumonia"" supported by the sentence: ""According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.""?",False, +10209213,Ciprofloxacin causes infectious disease,613,"Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.","Is the triple ""Ciprofloxacin causes infectious disease"" supported by the sentence: ""Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.""?",False, +7113733,Ciprofloxacin causes osteomyelitis,614,A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.,"Is the triple ""Ciprofloxacin causes osteomyelitis"" supported by the sentence: ""A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.""?",False, +21996198,Ciprofloxacin affects infectious disease,615,Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.,"Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.""?",False, +16563368,Ciprofloxacin affects Fever,616,"Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.""?",False, +16125923,Ciprofloxacin affects osteomyelitis,617,"Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.","Is the triple ""Ciprofloxacin affects osteomyelitis"" supported by the sentence: ""Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.""?",False, +12942741,Ciprofloxacin affects Crohn disease,618,BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.,"Is the triple ""Ciprofloxacin affects Crohn disease"" supported by the sentence: ""BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.""?",False, +11440816,Ciprofloxacin affects typhoid fever,619,A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.,"Is the triple ""Ciprofloxacin affects typhoid fever"" supported by the sentence: ""A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.""?",False, +11267024,Ciprofloxacin affects eye infectious disorder,620,The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).,"Is the triple ""Ciprofloxacin affects eye infectious disorder"" supported by the sentence: ""The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).""?",False, +10672042,Ciprofloxacin affects Abdominal Infection,621,The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.,"Is the triple ""Ciprofloxacin affects Abdominal Infection"" supported by the sentence: ""The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.""?",False, +9891814,Ciprofloxacin affects pneumonia,622,"This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.","Is the triple ""Ciprofloxacin affects pneumonia"" supported by the sentence: ""This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.""?",False, +9122989,Ciprofloxacin affects infectious disease,623,"The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.","Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.""?",False, +8956826,Ciprofloxacin affects Pseudomonas infection,624,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects Pseudomonas infection"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, +8956825,Ciprofloxacin affects cystic fibrosis,625,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects cystic fibrosis"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, +8669720,Ciprofloxacin affects Fever,626,"(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.""?",False, +7886704,Ciprofloxacin affects bronchiectasis,627,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects bronchiectasis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, +7886701,Ciprofloxacin affects chronic bronchitis,628,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects chronic bronchitis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, +7781719,Ciprofloxacin affects DNA Gyrase,629,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.","Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.""?",False, +7592205,Ciprofloxacin affects chronic obstructive pulmonary disease,630,"Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.","Is the triple ""Ciprofloxacin affects chronic obstructive pulmonary disease"" supported by the sentence: ""Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.""?",False, +18400322,Ciprofloxacin affects DNA Gyrase,631,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,"Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.""?",False, +26984478,Ciprofloxacin disrupts Fever,632,"In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.","Is the triple ""Ciprofloxacin disrupts Fever"" supported by the sentence: ""In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.""?",False, +26466958,Ciprofloxacin disrupts pneumonia,633,"At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.","Is the triple ""Ciprofloxacin disrupts pneumonia"" supported by the sentence: ""At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.""?",False, +18480207,Ciprofloxacin disrupts infectious disease,634,"We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.","Is the triple ""Ciprofloxacin disrupts infectious disease"" supported by the sentence: ""We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.""?",False, +10323767,Ciprofloxacin disrupts bacterial infectious disease with sepsis,635,Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.,"Is the triple ""Ciprofloxacin disrupts bacterial infectious disease with sepsis"" supported by the sentence: ""Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.""?",False, +27242944,Ciprofloxacin prevents pyelonephritis,636,"In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.","Is the triple ""Ciprofloxacin prevents pyelonephritis"" supported by the sentence: ""In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.""?",False, +21807033,Ciprofloxacin prevents Infection,637,25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.,"Is the triple ""Ciprofloxacin prevents Infection"" supported by the sentence: ""25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.""?",False, +16138544,Ciprofloxacin prevents diarrheal disease,638,"Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.","Is the triple ""Ciprofloxacin prevents diarrheal disease"" supported by the sentence: ""Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.""?",False, +15438014,Ciprofloxacin prevents Sepsis,639,"CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.","Is the triple ""Ciprofloxacin prevents Sepsis"" supported by the sentence: ""CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.""?",False, +14202377,Ciprofloxacin prevents plague,640,"Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.","Is the triple ""Ciprofloxacin prevents plague"" supported by the sentence: ""Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.""?",False, +12292532,Ciprofloxacin prevents endophthalmitis,641,These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.,"Is the triple ""Ciprofloxacin prevents endophthalmitis"" supported by the sentence: ""These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.""?",False, +10767980,Ciprofloxacin prevents bacterial infectious disease with sepsis,642,"To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.","Is the triple ""Ciprofloxacin prevents bacterial infectious disease with sepsis"" supported by the sentence: ""To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.""?",False, +9947057,Ciprofloxacin prevents bacterial infectious disease,643,[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].,"Is the triple ""Ciprofloxacin prevents bacterial infectious disease"" supported by the sentence: ""[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].""?",False, +8364719,Ciprofloxacin prevents pneumonia,644,The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.,"Is the triple ""Ciprofloxacin prevents pneumonia"" supported by the sentence: ""The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.""?",False, +8054296,Ciprofloxacin prevents infectious disease,645,"PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.","Is the triple ""Ciprofloxacin prevents infectious disease"" supported by the sentence: ""PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.""?",False, +18366035,Ciprofloxacin predisposes infectious disease,646,"Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.","Is the triple ""Ciprofloxacin predisposes infectious disease"" supported by the sentence: ""Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.""?",False, +15459841,Ciprofloxacin predisposes bacterial infectious disease with sepsis,647,"CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.","Is the triple ""Ciprofloxacin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.""?",False, +8758764,Ciprofloxacin predisposes gonorrhea,648,These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.,"Is the triple ""Ciprofloxacin predisposes gonorrhea"" supported by the sentence: ""These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.""?",False, +15493028,Chloramphenicol disrupts acne,649,Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.,"Is the triple ""Chloramphenicol disrupts acne"" supported by the sentence: ""Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.""?",False, +21241586,Chloramphenicol prevents eye infectious disorder,650,"Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.","Is the triple ""Chloramphenicol prevents eye infectious disorder"" supported by the sentence: ""Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.""?",False, +16722213,Rebamipide causes osteoarthritis,651,Oral administration of rebamipide was initiated on the day of OA induction.,"Is the triple ""Rebamipide causes osteoarthritis"" supported by the sentence: ""Oral administration of rebamipide was initiated on the day of OA induction.""?",False, +27679650,Rebamipide affects peptic ulcer disease,652,Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.,"Is the triple ""Rebamipide affects peptic ulcer disease"" supported by the sentence: ""Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.""?",False, +10125846,Rebamipide affects gastric ulcer,653,Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.,"Is the triple ""Rebamipide affects gastric ulcer"" supported by the sentence: ""Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.""?",False, +16923576,Rebamipide disrupts gastritis,654,"Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.","Is the triple ""Rebamipide disrupts gastritis"" supported by the sentence: ""Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.""?",False, +20953135,Rebamipide prevents peptic ulcer disease,655,CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).,"Is the triple ""Rebamipide prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).""?",False, +13727344,Rebamipide prevents gastritis,656,Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.,"Is the triple ""Rebamipide prevents gastritis"" supported by the sentence: ""Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.""?",False, +10452606,Rebamipide prevents gastric ulcer,657,These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.,"Is the triple ""Rebamipide prevents gastric ulcer"" supported by the sentence: ""These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.""?",False, +23020953,DINUTUXIMAB related to neoplasm,658,"In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.","Is the triple ""DINUTUXIMAB related to neoplasm"" supported by the sentence: ""In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.""?",False, +12385638,DINUTUXIMAB related to neuroblastoma,659,The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.,"Is the triple ""DINUTUXIMAB related to neuroblastoma"" supported by the sentence: ""The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.""?",False, +21974466,DINUTUXIMAB causes neuroblastoma,660,Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.,"Is the triple ""DINUTUXIMAB causes neuroblastoma"" supported by the sentence: ""Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.""?",False, +23929422,BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma,661,INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).,"Is the triple ""BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma"" supported by the sentence: ""INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).""?",False, +23730531,BRENTUXIMAB VEDOTIN related to mycosis fungoides,662,"These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to mycosis fungoides"" supported by the sentence: ""These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.""?",False, +23653011,BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma,663,Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.,"Is the triple ""BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma"" supported by the sentence: ""Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.""?",False, +23065539,BRENTUXIMAB VEDOTIN related to lymphoma,664,"Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to lymphoma"" supported by the sentence: ""Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.""?",False, +21812241,BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma,665,Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.,"Is the triple ""BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma"" supported by the sentence: ""Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.""?",False, +21657994,BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma,666,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, +21657993,BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma,667,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, +22071488,BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma,668,Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.,"Is the triple ""BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.""?",False, +21553377,BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma,669,"Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.","Is the triple ""BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma"" supported by the sentence: ""Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.""?",False, +23435913,BRENTUXIMAB VEDOTIN affects lymphoma,670,"Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.","Is the triple ""BRENTUXIMAB VEDOTIN affects lymphoma"" supported by the sentence: ""Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.""?",False, +20170701,Tetracycline causes periodontitis,671,"In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.","Is the triple ""Tetracycline causes periodontitis"" supported by the sentence: ""In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.""?",False, +19472933,Tetracycline causes Helicobacter pylori infectious disease,672,"In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.","Is the triple ""Tetracycline causes Helicobacter pylori infectious disease"" supported by the sentence: ""In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.""?",False, +18080767,Tetracycline affects periodontitis,673,Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.,"Is the triple ""Tetracycline affects periodontitis"" supported by the sentence: ""Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.""?",False, +17969405,Tetracycline affects bacterial infectious disease,674,"We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.","Is the triple ""Tetracycline affects bacterial infectious disease"" supported by the sentence: ""We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.""?",False, +24565223,Tetracycline prevents bacterial infectious disease,675,"Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .","Is the triple ""Tetracycline prevents bacterial infectious disease"" supported by the sentence: ""Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .""?",False, +10847016,Tetracycline prevents inclusion conjunctivitis,676,"Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.","Is the triple ""Tetracycline prevents inclusion conjunctivitis"" supported by the sentence: ""Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.""?",False, +12376615,(Alginate)n related to gastroesophageal reflux disease,677,Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.,"Is the triple ""(Alginate)n related to gastroesophageal reflux disease"" supported by the sentence: ""Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.""?",False, +11754791,(Alginate)n related to cystic fibrosis,678,Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.,"Is the triple ""(Alginate)n related to cystic fibrosis"" supported by the sentence: ""Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.""?",False, +10599430,(Alginate)n related to obesity disorder,679,[Alginate--skimmed milk mixture as an aid in obesity].,"Is the triple ""(Alginate)n related to obesity disorder"" supported by the sentence: ""[Alginate--skimmed milk mixture as an aid in obesity].""?",False, +27435796,(Alginate)n affects cystic fibrosis,680,"Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.","Is the triple ""(Alginate)n affects cystic fibrosis"" supported by the sentence: ""Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.""?",False, +27132270,(Alginate)n affects gastroesophageal reflux disease,681,Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.""?",False, +23415127,(Alginate)n affects obesity disorder,682,"Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.","Is the triple ""(Alginate)n affects obesity disorder"" supported by the sentence: ""Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.""?",False, +19854419,(Alginate)n affects gastroesophageal reflux disease,683,Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.""?",False, +8246131,(Alginate)n disrupts gastroesophageal reflux disease,684,"Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.","Is the triple ""(Alginate)n disrupts gastroesophageal reflux disease"" supported by the sentence: ""Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.""?",False, +11492096,(Alginate)n prevents gastroesophageal reflux disease,685,Alginic acid decreases postprandial upright gastroesophageal reflux.,"Is the triple ""(Alginate)n prevents gastroesophageal reflux disease"" supported by the sentence: ""Alginic acid decreases postprandial upright gastroesophageal reflux.""?",False, +23508922,(Alginate)n predisposes obesity disorder,686,The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.,"Is the triple ""(Alginate)n predisposes obesity disorder"" supported by the sentence: ""The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.""?",False, +11597598,Zolimidine related to peptic ulcer disease,687,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Zolimidine related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, +20742970,Chlorhexidine causes infectious disease,688,"Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.","Is the triple ""Chlorhexidine causes infectious disease"" supported by the sentence: ""Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.""?",False, +16147932,Chlorhexidine causes gingivitis,689,CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.,"Is the triple ""Chlorhexidine causes gingivitis"" supported by the sentence: ""CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.""?",False, +15413413,Chlorhexidine causes stomatitis,690,Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.,"Is the triple ""Chlorhexidine causes stomatitis"" supported by the sentence: ""Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.""?",False, +13735208,Chlorhexidine causes bacterial infectious disease with sepsis,691,Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.,"Is the triple ""Chlorhexidine causes bacterial infectious disease with sepsis"" supported by the sentence: ""Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.""?",False, +23793676,Chlorhexidine affects Infection,692,This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.,"Is the triple ""Chlorhexidine affects Infection"" supported by the sentence: ""This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.""?",False, +21319017,Chlorhexidine affects pneumonia,693,Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.,"Is the triple ""Chlorhexidine affects pneumonia"" supported by the sentence: ""Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.""?",False, +20585434,Chlorhexidine affects stomatitis,694,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Chlorhexidine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, +13503760,Chlorhexidine affects periodontal disorder,695,"Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.","Is the triple ""Chlorhexidine affects periodontal disorder"" supported by the sentence: ""Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.""?",False, +8506996,Chlorhexidine affects gingivitis,696,Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.,"Is the triple ""Chlorhexidine affects gingivitis"" supported by the sentence: ""Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.""?",False, +25489531,"Chlorhexidine disrupts Pneumonia, Ventilator-Associated",697,"Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).","Is the triple ""Chlorhexidine disrupts Pneumonia, Ventilator-Associated"" supported by the sentence: ""Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).""?",False, +22304373,Chlorhexidine disrupts dental caries,698,This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.,"Is the triple ""Chlorhexidine disrupts dental caries"" supported by the sentence: ""This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.""?",False, +21939464,Chlorhexidine disrupts Infection,699,"In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).","Is the triple ""Chlorhexidine disrupts Infection"" supported by the sentence: ""In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).""?",False, +19793680,Chlorhexidine disrupts bacterial infectious disease,700,This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.,"Is the triple ""Chlorhexidine disrupts bacterial infectious disease"" supported by the sentence: ""This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.""?",False, +18040358,Chlorhexidine disrupts infectious disease,701,Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.,"Is the triple ""Chlorhexidine disrupts infectious disease"" supported by the sentence: ""Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.""?",False, +11272633,Chlorhexidine disrupts gingivitis,702,The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.,"Is the triple ""Chlorhexidine disrupts gingivitis"" supported by the sentence: ""The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.""?",False, +26042520,Chlorhexidine prevents staphylococcal infection,703,"It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.","Is the triple ""Chlorhexidine prevents staphylococcal infection"" supported by the sentence: ""It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.""?",False, +22617089,Chlorhexidine prevents periodontitis,704,"Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.","Is the triple ""Chlorhexidine prevents periodontitis"" supported by the sentence: ""Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.""?",False, +22038778,Chlorhexidine prevents bacterial infectious disease,705,"CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.","Is the triple ""Chlorhexidine prevents bacterial infectious disease"" supported by the sentence: ""CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.""?",False, +22000060,Chlorhexidine prevents Infection,706,"Thus, CHX can be used to prevent subsequent biofilm infections.","Is the triple ""Chlorhexidine prevents Infection"" supported by the sentence: ""Thus, CHX can be used to prevent subsequent biofilm infections.""?",False, +21737487,"Chlorhexidine prevents Pneumonia, Ventilator-Associated",707,Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.,"Is the triple ""Chlorhexidine prevents Pneumonia, Ventilator-Associated"" supported by the sentence: ""Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.""?",False, +19905103,Chlorhexidine prevents periodontal disorder,708,"The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.","Is the triple ""Chlorhexidine prevents periodontal disorder"" supported by the sentence: ""The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.""?",False, +16765643,Chlorhexidine prevents Neonatal sepsis,709,AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).,"Is the triple ""Chlorhexidine prevents Neonatal sepsis"" supported by the sentence: ""AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).""?",False, +14052320,Chlorhexidine prevents pneumonia,710,Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.,"Is the triple ""Chlorhexidine prevents pneumonia"" supported by the sentence: ""Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.""?",False, +11830955,Chlorhexidine prevents bacterial infectious disease with sepsis,711,"Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.","Is the triple ""Chlorhexidine prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.""?",False, +11145796,Chlorhexidine prevents infectious disease,712,CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.,"Is the triple ""Chlorhexidine prevents infectious disease"" supported by the sentence: ""CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.""?",False, +10739867,Chlorhexidine prevents stomatitis,713,"The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.","Is the triple ""Chlorhexidine prevents stomatitis"" supported by the sentence: ""The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.""?",False, +10141569,Chlorhexidine prevents dental caries,714,The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.,"Is the triple ""Chlorhexidine prevents dental caries"" supported by the sentence: ""The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.""?",False, +7990742,Chlorhexidine prevents gingivitis,715,"Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.","Is the triple ""Chlorhexidine prevents gingivitis"" supported by the sentence: ""Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.""?",False, +23454202,"Chlorhexidine predisposes Pneumonia, Ventilator-Associated",716,"The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.","Is the triple ""Chlorhexidine predisposes Pneumonia, Ventilator-Associated"" supported by the sentence: ""The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.""?",False, +19942414,Chlorhexidine predisposes periodontal disorder,717,CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.,"Is the triple ""Chlorhexidine predisposes periodontal disorder"" supported by the sentence: ""CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.""?",False, +18735040,Chlorhexidine predisposes dental caries,718,"Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.","Is the triple ""Chlorhexidine predisposes dental caries"" supported by the sentence: ""Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.""?",False, +16765642,Chlorhexidine predisposes Neonatal sepsis,719,Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.,"Is the triple ""Chlorhexidine predisposes Neonatal sepsis"" supported by the sentence: ""Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.""?",False, +24905090,Nicergoline causes depressive disorder,720,"RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.","Is the triple ""Nicergoline causes depressive disorder"" supported by the sentence: ""RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.""?",False, +25103280,RAMUCIRUMAB related to hepatocellular carcinoma,721,"Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.","Is the triple ""RAMUCIRUMAB related to hepatocellular carcinoma"" supported by the sentence: ""Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.""?",False, +22612331,RAMUCIRUMAB related to neoplasm,722,"CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.","Is the triple ""RAMUCIRUMAB related to neoplasm"" supported by the sentence: ""CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.""?",False, +21600131,RAMUCIRUMAB related to non-small cell lung carcinoma,723,Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.,"Is the triple ""RAMUCIRUMAB related to non-small cell lung carcinoma"" supported by the sentence: ""Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.""?",False, +22008312,RAMUCIRUMAB affects neoplasm,724,"This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).","Is the triple ""RAMUCIRUMAB affects neoplasm"" supported by the sentence: ""This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).""?",False, +23569571,TAFASITAMAB related to diffuse large B-cell lymphoma,725,The use of tafasitamab in diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB related to diffuse large B-cell lymphoma"" supported by the sentence: ""The use of tafasitamab in diffuse large B-cell lymphoma.""?",False, +24533103,TAFASITAMAB disrupts diffuse large B-cell lymphoma,726,MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB disrupts diffuse large B-cell lymphoma"" supported by the sentence: ""MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.""?",False, +21884997,Thioctic acid related to cystinuria,727,alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.,"Is the triple ""Thioctic acid related to cystinuria"" supported by the sentence: ""alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.""?",False, +20207321,Thioctic acid related to chronic progressive multiple sclerosis,728,Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.,"Is the triple ""Thioctic acid related to chronic progressive multiple sclerosis"" supported by the sentence: ""Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.""?",False, +18115881,Thioctic acid related to hypertensive disorder,729,"INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.","Is the triple ""Thioctic acid related to hypertensive disorder"" supported by the sentence: ""INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.""?",False, +15406106,Thioctic acid related to optic neuritis,730,This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.,"Is the triple ""Thioctic acid related to optic neuritis"" supported by the sentence: ""This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.""?",False, +12204809,Thioctic acid related to type 2 diabetes mellitus,731,"As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.","Is the triple ""Thioctic acid related to type 2 diabetes mellitus"" supported by the sentence: ""As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.""?",False, +11741203,Thioctic acid related to multiple sclerosis,732,Lipoic acid in multiple sclerosis: a pilot study.,"Is the triple ""Thioctic acid related to multiple sclerosis"" supported by the sentence: ""Lipoic acid in multiple sclerosis: a pilot study.""?",False, +11010945,Thioctic acid related to AIDS,733,These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.,"Is the triple ""Thioctic acid related to AIDS"" supported by the sentence: ""These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.""?",False, +10648973,Thioctic acid related to skin disorder,734,[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].,"Is the triple ""Thioctic acid related to skin disorder"" supported by the sentence: ""[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].""?",False, +7603472,Thioctic acid related to diabetic neuropathy,735,[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].,"Is the triple ""Thioctic acid related to diabetic neuropathy"" supported by the sentence: ""[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].""?",False, +16842192,Thioctic acid causes hypertensive disorder,736,"AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.","Is the triple ""Thioctic acid causes hypertensive disorder"" supported by the sentence: ""AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.""?",False, +21111426,Thioctic acid affects optic neuritis,737,"Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.","Is the triple ""Thioctic acid affects optic neuritis"" supported by the sentence: ""Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.""?",False, +18505755,Thioctic acid affects diabetic neuropathy,738,"Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.","Is the triple ""Thioctic acid affects diabetic neuropathy"" supported by the sentence: ""Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.""?",False, +17198477,Thioctic acid affects type 2 diabetes mellitus,739,"A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.","Is the triple ""Thioctic acid affects type 2 diabetes mellitus"" supported by the sentence: ""A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.""?",False, +12393284,Thioctic acid affects Alzheimer disease,740,"The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.","Is the triple ""Thioctic acid affects Alzheimer disease"" supported by the sentence: ""The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.""?",False, +9028391,Thioctic acid affects hypertensive disorder,741,"Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.","Is the triple ""Thioctic acid affects hypertensive disorder"" supported by the sentence: ""Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.""?",False, +21111429,Thioctic acid prevents optic neuritis,742,Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.,"Is the triple ""Thioctic acid prevents optic neuritis"" supported by the sentence: ""Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.""?",False, +18775341,Thioctic acid prevents skin disorder,743,"Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.","Is the triple ""Thioctic acid prevents skin disorder"" supported by the sentence: ""Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.""?",False, +18076378,Thioctic acid prevents type 2 diabetes mellitus,744,"Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.","Is the triple ""Thioctic acid prevents type 2 diabetes mellitus"" supported by the sentence: ""Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.""?",False, +15377554,Thioctic acid prevents stroke disorder,745,We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.,"Is the triple ""Thioctic acid prevents stroke disorder"" supported by the sentence: ""We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.""?",False, +13878249,Thioctic acid prevents Alzheimer disease,746,Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.,"Is the triple ""Thioctic acid prevents Alzheimer disease"" supported by the sentence: ""Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.""?",False, +8826102,Thioctic acid prevents hypertensive disorder,747,"The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.","Is the triple ""Thioctic acid prevents hypertensive disorder"" supported by the sentence: ""The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.""?",False, +8682086,Thioctic acid prevents diabetic neuropathy,748,alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.,"Is the triple ""Thioctic acid prevents diabetic neuropathy"" supported by the sentence: ""alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.""?",False, +15385084,Thioctic acid predisposes Alzheimer disease,749,"Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.","Is the triple ""Thioctic acid predisposes Alzheimer disease"" supported by the sentence: ""Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.""?",False, +26276598,Ampicillin related to Sepsis,750,Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.,"Is the triple ""Ampicillin related to Sepsis"" supported by the sentence: ""Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.""?",False, +19644222,Ampicillin related to pneumonia,751,"This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.","Is the triple ""Ampicillin related to pneumonia"" supported by the sentence: ""This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.""?",False, +27702232,Ampicillin causes Sepsis,752,Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.,"Is the triple ""Ampicillin causes Sepsis"" supported by the sentence: ""Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.""?",False, +15854005,Ampicillin causes pneumonia,753,"Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.","Is the triple ""Ampicillin causes pneumonia"" supported by the sentence: ""Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.""?",False, +14938843,Ampicillin affects Sepsis,754,"No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.","Is the triple ""Ampicillin affects Sepsis"" supported by the sentence: ""No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.""?",False, +8930713,Ampicillin affects gonorrhea,755,A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.,"Is the triple ""Ampicillin affects gonorrhea"" supported by the sentence: ""A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.""?",False, +21012437,Ampicillin disrupts gonorrhea,756,"Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.","Is the triple ""Ampicillin disrupts gonorrhea"" supported by the sentence: ""Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.""?",False, +24823382,Ampicillin prevents Infection,757,"Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.","Is the triple ""Ampicillin prevents Infection"" supported by the sentence: ""Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.""?",False, +22838487,Ampicillin prevents chorioamnionitis,758,OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.,"Is the triple ""Ampicillin prevents chorioamnionitis"" supported by the sentence: ""OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.""?",False, +18801502,Ampicillin prevents Sepsis,759,"JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.","Is the triple ""Ampicillin prevents Sepsis"" supported by the sentence: ""JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.""?",False, +17465667,Ampicillin prevents pneumonia,760,"Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).","Is the triple ""Ampicillin prevents pneumonia"" supported by the sentence: ""Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).""?",False, +13675414,Ampicillin predisposes Sepsis,761,Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.,"Is the triple ""Ampicillin predisposes Sepsis"" supported by the sentence: ""Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.""?",False, +26048573,Carbenicillin causes bacterial infectious disease,762,"Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.","Is the triple ""Carbenicillin causes bacterial infectious disease"" supported by the sentence: ""Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.""?",False, +19319362,Benzoyl Peroxide related to acne,763,"Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.","Is the triple ""Benzoyl Peroxide related to acne"" supported by the sentence: ""Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.""?",False, +10427135,Benzoyl Peroxide affects acne,764,The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).,"Is the triple ""Benzoyl Peroxide affects acne"" supported by the sentence: ""The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).""?",False, +7769964,Benzoyl Peroxide disrupts acne,765,We used benzoyl peroxide to bring about rapid suppression of P acnes.,"Is the triple ""Benzoyl Peroxide disrupts acne"" supported by the sentence: ""We used benzoyl peroxide to bring about rapid suppression of P acnes.""?",False, +12531968,Benzoyl Peroxide prevents acne,766,"Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.","Is the triple ""Benzoyl Peroxide prevents acne"" supported by the sentence: ""Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.""?",False, +11597597,Proglumide related to peptic ulcer disease,767,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Proglumide related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, +18195146,Pirenzepine causes peptic ulcer disease,768,Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.,"Is the triple ""Pirenzepine causes peptic ulcer disease"" supported by the sentence: ""Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.""?",False, +13022427,Pirenzepine affects gastroesophageal reflux disease,769,"However, the effect of pirenzepine on GERD remains to be defined.","Is the triple ""Pirenzepine affects gastroesophageal reflux disease"" supported by the sentence: ""However, the effect of pirenzepine on GERD remains to be defined.""?",False, +18547780,Pirenzepine prevents peptic ulcer disease,770,Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.,"Is the triple ""Pirenzepine prevents peptic ulcer disease"" supported by the sentence: ""Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.""?",False, +9345084,Magnesium Oxide related to constipation disorder,771,"In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.","Is the triple ""Magnesium Oxide related to constipation disorder"" supported by the sentence: ""In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.""?",False, +19628284,Magnesium Oxide disrupts constipation disorder,772,"However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.","Is the triple ""Magnesium Oxide disrupts constipation disorder"" supported by the sentence: ""However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.""?",False, +25714783,Ticarcillin prevents Sepsis,773,A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.,"Is the triple ""Ticarcillin prevents Sepsis"" supported by the sentence: ""A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.""?",False, +24735602,Urea related to hepatocellular carcinoma,774,"Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.","Is the triple ""Urea related to hepatocellular carcinoma"" supported by the sentence: ""Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.""?",False, +18901918,Urea related to radiodermatitis,775,AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.,"Is the triple ""Urea related to radiodermatitis"" supported by the sentence: ""AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.""?",False, +16423422,Urea related to skin disorder,776,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to skin disorder"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, +16423421,Urea related to psoriasis,777,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to psoriasis"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, +10983160,"Urea related to dermatitis, atopic",778,[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].,"Is the triple ""Urea related to dermatitis, atopic"" supported by the sentence: ""[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].""?",False, +9883467,Urea related to diabetes mellitus,779,"Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.","Is the triple ""Urea related to diabetes mellitus"" supported by the sentence: ""Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.""?",False, +9435238,Urea related to type 2 diabetes mellitus,780,"Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.","Is the triple ""Urea related to type 2 diabetes mellitus"" supported by the sentence: ""Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.""?",False, +7778173,Urea related to ornithine carbamoyltransferase deficiency,781,We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).,"Is the triple ""Urea related to ornithine carbamoyltransferase deficiency"" supported by the sentence: ""We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).""?",False, +17162115,Urea causes diabetes mellitus,782,"Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.","Is the triple ""Urea causes diabetes mellitus"" supported by the sentence: ""Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.""?",False, +16469778,Urea causes type 2 diabetes mellitus,783,"To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.","Is the triple ""Urea causes type 2 diabetes mellitus"" supported by the sentence: ""To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.""?",False, +18510405,Urea affects hepatocellular carcinoma,784,[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].,"Is the triple ""Urea affects hepatocellular carcinoma"" supported by the sentence: ""[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].""?",False, +10531949,Urea affects diabetes mellitus,785,[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].,"Is the triple ""Urea affects diabetes mellitus"" supported by the sentence: ""[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].""?",False, +8735554,Urea affects type 2 diabetes mellitus,786,Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.,"Is the triple ""Urea affects type 2 diabetes mellitus"" supported by the sentence: ""Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.""?",False, +25972859,Urea produces citrullinemia,787,Citrullinemia with defective urea production.,"Is the triple ""Urea produces citrullinemia"" supported by the sentence: ""Citrullinemia with defective urea production.""?",False, +18901919,Urea prevents radiodermatitis,788,This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.,"Is the triple ""Urea prevents radiodermatitis"" supported by the sentence: ""This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.""?",False, +15303897,Urea prevents Palmar-plantar erythrodysesthesia syndrome,789,This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.,"Is the triple ""Urea prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.""?",False, +19154964,Urea predisposes type 2 diabetes mellitus,790,"A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.","Is the triple ""Urea predisposes type 2 diabetes mellitus"" supported by the sentence: ""A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.""?",False, +21175471,Mannitol related to intracranial hypertension,791,"To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.","Is the triple ""Mannitol related to intracranial hypertension"" supported by the sentence: ""To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.""?",False, +17706176,Mannitol related to acute kidney failure,792,"Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.","Is the triple ""Mannitol related to acute kidney failure"" supported by the sentence: ""Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.""?",False, +17429747,Mannitol related to stroke disorder,793,The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.,"Is the triple ""Mannitol related to stroke disorder"" supported by the sentence: ""The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.""?",False, +15130853,Mannitol related to brain cancer,794,"In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.","Is the triple ""Mannitol related to brain cancer"" supported by the sentence: ""In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.""?",False, +13201402,Mannitol related to cystic fibrosis,795,Inhaled mannitol in cystic fibrosis.,"Is the triple ""Mannitol related to cystic fibrosis"" supported by the sentence: ""Inhaled mannitol in cystic fibrosis.""?",False, +12470912,Mannitol related to brain edema,796,"The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.","Is the triple ""Mannitol related to brain edema"" supported by the sentence: ""The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.""?",False, +11875924,Mannitol related to ciguatera fish poisoning,797,"The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.","Is the triple ""Mannitol related to ciguatera fish poisoning"" supported by the sentence: ""The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.""?",False, +10780851,Mannitol related to brain injury,798,Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.,"Is the triple ""Mannitol related to brain injury"" supported by the sentence: ""Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.""?",False, +8946483,Mannitol related to bronchiectasis,799,"REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.","Is the triple ""Mannitol related to bronchiectasis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.""?",False, +7891128,Mannitol related to injury,800,"The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.","Is the triple ""Mannitol related to injury"" supported by the sentence: ""The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.""?",False, +26278567,Mannitol causes brain cancer,801,Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.,"Is the triple ""Mannitol causes brain cancer"" supported by the sentence: ""Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.""?",False, +25099324,Mannitol causes hearing loss disorder,802,A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.,"Is the triple ""Mannitol causes hearing loss disorder"" supported by the sentence: ""A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.""?",False, +21259902,Mannitol causes brain injury,803,"In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.","Is the triple ""Mannitol causes brain injury"" supported by the sentence: ""In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.""?",False, +18351985,Mannitol causes hypotensive disorder,804,"All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.","Is the triple ""Mannitol causes hypotensive disorder"" supported by the sentence: ""All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.""?",False, +15545947,Mannitol causes brain edema,805,"This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.","Is the triple ""Mannitol causes brain edema"" supported by the sentence: ""This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.""?",False, +12105301,Mannitol causes intracranial hypertension,806,"There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.","Is the triple ""Mannitol causes intracranial hypertension"" supported by the sentence: ""There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.""?",False, +11383337,Mannitol causes injury,807,DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.,"Is the triple ""Mannitol causes injury"" supported by the sentence: ""DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.""?",False, +9825580,Mannitol causes acute kidney failure,808,"In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.","Is the triple ""Mannitol causes acute kidney failure"" supported by the sentence: ""In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.""?",False, +22439282,Mannitol affects acute kidney failure,809,Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.,"Is the triple ""Mannitol affects acute kidney failure"" supported by the sentence: ""Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.""?",False, +18431992,Mannitol affects hypotensive disorder,810,It is unknown if mannitol is a contributing factor in the observed hypotension.,"Is the triple ""Mannitol affects hypotensive disorder"" supported by the sentence: ""It is unknown if mannitol is a contributing factor in the observed hypotension.""?",False, +10780860,Mannitol affects brain injury,811,"Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.","Is the triple ""Mannitol affects brain injury"" supported by the sentence: ""Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.""?",False, +10701562,Mannitol affects injury,812,THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.,"Is the triple ""Mannitol affects injury"" supported by the sentence: ""THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.""?",False, +10686125,"Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive",813,"EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.","Is the triple ""Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.""?",False, +9315186,Mannitol affects intracranial hypertension,814,"OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.","Is the triple ""Mannitol affects intracranial hypertension"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.""?",False, +7084537,Mannitol affects brain edema,815,The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.,"Is the triple ""Mannitol affects brain edema"" supported by the sentence: ""The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.""?",False, +27493988,Mannitol disrupts injury,816,"We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.","Is the triple ""Mannitol disrupts injury"" supported by the sentence: ""We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.""?",False, +26052295,Mannitol disrupts brain edema,817,Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.,"Is the triple ""Mannitol disrupts brain edema"" supported by the sentence: ""Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.""?",False, +18331127,Mannitol prevents Pain,818,"Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.","Is the triple ""Mannitol prevents Pain"" supported by the sentence: ""Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.""?",False, +17838550,Mannitol prevents brain injury,819,"Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.","Is the triple ""Mannitol prevents brain injury"" supported by the sentence: ""Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.""?",False, +9550870,Mannitol prevents acute kidney failure,820,"However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.","Is the triple ""Mannitol prevents acute kidney failure"" supported by the sentence: ""However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.""?",False, +8530867,Mannitol prevents brain edema,821,BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.,"Is the triple ""Mannitol prevents brain edema"" supported by the sentence: ""BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.""?",False, +7816754,Mannitol prevents intracranial hypertension,822,"For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.","Is the triple ""Mannitol prevents intracranial hypertension"" supported by the sentence: ""For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.""?",False, +21038220,Mannitol exacerbates intracranial hypertension,823,Does a bolus of mannitol initially aggravate intracranial hypertension?,"Is the triple ""Mannitol exacerbates intracranial hypertension"" supported by the sentence: ""Does a bolus of mannitol initially aggravate intracranial hypertension?""?",False, +23554906,Mannitol predisposes brain injury,824,"This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.","Is the triple ""Mannitol predisposes brain injury"" supported by the sentence: ""This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.""?",False, +23171283,Mannitol predisposes acute kidney failure,825,"In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).","Is the triple ""Mannitol predisposes acute kidney failure"" supported by the sentence: ""In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).""?",False, +15337034,Mannitol predisposes brain edema,826,D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.,"Is the triple ""Mannitol predisposes brain edema"" supported by the sentence: ""D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.""?",False, +9368450,Mannitol predisposes injury,827,"Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.","Is the triple ""Mannitol predisposes injury"" supported by the sentence: ""Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.""?",False, +25560945,Artesunic acid affects neoplasm,828,Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.""?",False, +20380317,Artesunic acid affects neoplasm,829,Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.""?",False, +17022154,Artesunic acid affects cytomegalovirus infection,830,"OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.","Is the triple ""Artesunic acid affects cytomegalovirus infection"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.""?",False, +15447136,Artesunic acid affects malaria,831,BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.,"Is the triple ""Artesunic acid affects malaria"" supported by the sentence: ""BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.""?",False, +14695052,Artesunic acid affects Fever,832,"In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.","Is the triple ""Artesunic acid affects Fever"" supported by the sentence: ""In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.""?",False, +9350747,Artesunic acid affects Plasmodium falciparum malaria,833,The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.,"Is the triple ""Artesunic acid affects Plasmodium falciparum malaria"" supported by the sentence: ""The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.""?",False, +19053159,Artesunic acid disrupts Plasmodium falciparum malaria,834,"BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.","Is the triple ""Artesunic acid disrupts Plasmodium falciparum malaria"" supported by the sentence: ""BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.""?",False, +17269195,Artesunic acid disrupts neoplasm,835,The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.,"Is the triple ""Artesunic acid disrupts neoplasm"" supported by the sentence: ""The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.""?",False, +16806460,Artesunic acid disrupts malaria,836,"CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.","Is the triple ""Artesunic acid disrupts malaria"" supported by the sentence: ""CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.""?",False, +10013375,Artesunic acid prevents schistosomiasis,837,CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.,"Is the triple ""Artesunic acid prevents schistosomiasis"" supported by the sentence: ""CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.""?",False, +8540473,Artesunic acid prevents malaria,838,"INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.","Is the triple ""Artesunic acid prevents malaria"" supported by the sentence: ""INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.""?",False, +16567243,Artesunic acid predisposes malaria,839,"We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.","Is the triple ""Artesunic acid predisposes malaria"" supported by the sentence: ""We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.""?",False, +27639365,Artemether affects Fever,840,RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.,"Is the triple ""Artemether affects Fever"" supported by the sentence: ""RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.""?",False, +25565511,Artemether affects malaria,841,Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.,"Is the triple ""Artemether affects malaria"" supported by the sentence: ""Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.""?",False, +19253720,Artemether prevents malaria,842,New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.,"Is the triple ""Artemether prevents malaria"" supported by the sentence: ""New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.""?",False, +10002115,Artemether prevents urinary schistosomiasis,843,"Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.","Is the triple ""Artemether prevents urinary schistosomiasis"" supported by the sentence: ""Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.""?",False, +8716445,Isoproterenol causes atrial fibrillation,844,"A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).","Is the triple ""Isoproterenol causes atrial fibrillation"" supported by the sentence: ""A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).""?",False, +25912644,Isoproterenol affects obstructive lung disease,845,The effect of isoproterenol on airway obstruction in cystic fibrosis.,"Is the triple ""Isoproterenol affects obstructive lung disease"" supported by the sentence: ""The effect of isoproterenol on airway obstruction in cystic fibrosis.""?",False, +24900253,Isoproterenol affects obesity disorder,846,"OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.","Is the triple ""Isoproterenol affects obesity disorder"" supported by the sentence: ""OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.""?",False, +9298156,Isoproterenol affects atrial fibrillation,847,[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].,"Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].""?",False, +7542857,Isoproterenol affects atrial fibrillation,848,"OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.","Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.""?",False, +26721271,Isoproterenol disrupts obesity disorder,849,"In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.","Is the triple ""Isoproterenol disrupts obesity disorder"" supported by the sentence: ""In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.""?",False, +7635739,Isoproterenol predisposes atrial fibrillation,850,The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.,"Is the triple ""Isoproterenol predisposes atrial fibrillation"" supported by the sentence: ""The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.""?",False, +23874783,Bacitracin A related to pneumonia,851,"These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .","Is the triple ""Bacitracin A related to pneumonia"" supported by the sentence: ""These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .""?",False, +26428368,Bacitracin A prevents bacterial infectious disease,852,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Bacitracin A prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, +18829774,Bacitracin A prevents cardiac rhythm disease,853,"The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.","Is the triple ""Bacitracin A prevents cardiac rhythm disease"" supported by the sentence: ""The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.""?",False, +16650012,Diflunisal subclass of Diflunisal glucuronide ester,854,"We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.","Is the triple ""Diflunisal subclass of Diflunisal glucuronide ester"" supported by the sentence: ""We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.""?",False, +26133976,Diflunisal causes Pain,855,"Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).","Is the triple ""Diflunisal causes Pain"" supported by the sentence: ""Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).""?",False, +26132411,Diflunisal affects Pain,856,[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].,"Is the triple ""Diflunisal affects Pain"" supported by the sentence: ""[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].""?",False, +26009871,Diflunisal affects Fever,857,"In contrast, submaximal fever in rabbits was not reduced by diflunisal.","Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""In contrast, submaximal fever in rabbits was not reduced by diflunisal.""?",False, +26009870,Diflunisal affects Fever,858,Effects of diflunisal on fever in the rabbit and the rat.,"Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""Effects of diflunisal on fever in the rabbit and the rat.""?",False, +13234484,Diflunisal affects Diflunisal glucuronide ester,859,"Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.","Is the triple ""Diflunisal affects Diflunisal glucuronide ester"" supported by the sentence: ""Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.""?",False, +14757294,Diflunisal prevents Pain,860,"It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.","Is the triple ""Diflunisal prevents Pain"" supported by the sentence: ""It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.""?",False, +17020332,Salsalate causes Insulin resistance,861,"Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.","Is the triple ""Salsalate causes Insulin resistance"" supported by the sentence: ""Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.""?",False, +21902985,Salsalate affects diabetes mellitus,862,Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.,"Is the triple ""Salsalate affects diabetes mellitus"" supported by the sentence: ""Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.""?",False, +25541729,Salsalate disrupts Insulin resistance,863,Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.,"Is the triple ""Salsalate disrupts Insulin resistance"" supported by the sentence: ""Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.""?",False, +19533984,Salsalate prevents diabetes mellitus,864,"Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.","Is the triple ""Salsalate prevents diabetes mellitus"" supported by the sentence: ""Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.""?",False, +26431050,Sodium salicylate causes Fever,865,"Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.","Is the triple ""Sodium salicylate causes Fever"" supported by the sentence: ""Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.""?",False, +11882723,Sodium salicylate affects Fever,866,A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.""?",False, +9968696,Sodium salicylate affects Fever,867,The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).""?",False, +15893532,Sodium salicylate predisposes Pain,868,Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.,"Is the triple ""Sodium salicylate predisposes Pain"" supported by the sentence: ""Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.""?",False, +7201382,Aspirin subclass of Salicylic Acid,869,"The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.","Is the triple ""Aspirin subclass of Salicylic Acid"" supported by the sentence: ""The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.""?",False, +26818861,Aspirin related to myocardial infarction,870,Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.,"Is the triple ""Aspirin related to myocardial infarction"" supported by the sentence: ""Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.""?",False, +26532873,Aspirin related to classic familial adenomatous polyposis,871,The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.,"Is the triple ""Aspirin related to classic familial adenomatous polyposis"" supported by the sentence: ""The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.""?",False, +26329928,Aspirin related to type 2 diabetes mellitus,872,Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.,"Is the triple ""Aspirin related to type 2 diabetes mellitus"" supported by the sentence: ""Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.""?",False, +26168722,Aspirin related to Inflammation,873,"The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.","Is the triple ""Aspirin related to Inflammation"" supported by the sentence: ""The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.""?",False, +24076103,Aspirin related to Hemorrhage,874,"Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.","Is the triple ""Aspirin related to Hemorrhage"" supported by the sentence: ""Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.""?",False, +20241570,Aspirin related to Pain,875,Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.,"Is the triple ""Aspirin related to Pain"" supported by the sentence: ""Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.""?",False, +18524506,Aspirin related to cataract,876,Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.,"Is the triple ""Aspirin related to cataract"" supported by the sentence: ""Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.""?",False, +18008074,Aspirin related to diabetes mellitus,877,"It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).","Is the triple ""Aspirin related to diabetes mellitus"" supported by the sentence: ""It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).""?",False, +17483160,Aspirin related to mucocutaneous lymph node syndrome,878,We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.,"Is the triple ""Aspirin related to mucocutaneous lymph node syndrome"" supported by the sentence: ""We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.""?",False, +16078277,Aspirin related to preeclampsia,879,Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.,"Is the triple ""Aspirin related to preeclampsia"" supported by the sentence: ""Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.""?",False, +15283505,Aspirin related to thrombotic disease,880,"The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.","Is the triple ""Aspirin related to thrombotic disease"" supported by the sentence: ""The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.""?",False, +13829413,Aspirin related to retinal vein occlusion,881,Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.,"Is the triple ""Aspirin related to retinal vein occlusion"" supported by the sentence: ""Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.""?",False, +13174915,Aspirin related to ST-elevation myocardial infarction,882,"The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.","Is the triple ""Aspirin related to ST-elevation myocardial infarction"" supported by the sentence: ""The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.""?",False, +12865539,Aspirin related to cardiovascular disorder,883,"METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.","Is the triple ""Aspirin related to cardiovascular disorder"" supported by the sentence: ""METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.""?",False, +12749655,Aspirin related to Salicylic Acid,884,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, +12502970,Aspirin related to coronary artery disorder,885,Low-dose aspirin and heparin in unstable coronary artery disease.,"Is the triple ""Aspirin related to coronary artery disorder"" supported by the sentence: ""Low-dose aspirin and heparin in unstable coronary artery disease.""?",False, +10635434,Aspirin related to rheumatic heart disease,886,A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.,"Is the triple ""Aspirin related to rheumatic heart disease"" supported by the sentence: ""A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.""?",False, +10534181,Aspirin related to osteoarthritis,887,"A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.","Is the triple ""Aspirin related to osteoarthritis"" supported by the sentence: ""A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.""?",False, +10473195,Aspirin related to asthma,888,"Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.","Is the triple ""Aspirin related to asthma"" supported by the sentence: ""Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.""?",False, +9315521,Aspirin related to atrial fibrillation,889,"In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.","Is the triple ""Aspirin related to atrial fibrillation"" supported by the sentence: ""In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.""?",False, +8718389,Aspirin related to stroke disorder,890,Heparin and aspirin in stroke.,"Is the triple ""Aspirin related to stroke disorder"" supported by the sentence: ""Heparin and aspirin in stroke.""?",False, +8430499,Aspirin related to Ischemic stroke,891,Heparin versus aspirin in ischaemic stroke.,"Is the triple ""Aspirin related to Ischemic stroke"" supported by the sentence: ""Heparin versus aspirin in ischaemic stroke.""?",False, +7718877,Aspirin related to acute coronary syndrome,892,"In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.","Is the triple ""Aspirin related to acute coronary syndrome"" supported by the sentence: ""In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.""?",False, +8745735,Aspirin related to Salicylic Acid,893,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, +12749656,Aspirin close match Salicylic Acid,894,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, +8745736,Aspirin close match Salicylic Acid,895,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, +10716638,Aspirin coexists with Salicylic Acid,896,An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.,"Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.""?",False, +10182446,Aspirin coexists with Salicylic Acid,897,"A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.","Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.""?",False, +8959647,Aspirin derives from Salicylic Acid,898,Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.,"Is the triple ""Aspirin derives from Salicylic Acid"" supported by the sentence: ""Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.""?",False, +7421635,Aspirin physically interacts with Salicylic Acid,899,"Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.""?",False, +9047883,Aspirin physically interacts with Salicylic Acid,900,"Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.""?",False, +27550629,Aspirin causes transient ischemic attack,901,"In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).","Is the triple ""Aspirin causes transient ischemic attack"" supported by the sentence: ""In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).""?",False, +27093984,Aspirin causes Sepsis,902,Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).,"Is the triple ""Aspirin causes Sepsis"" supported by the sentence: ""Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).""?",False, +26941889,Aspirin causes colonic neoplasm,903,"Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.","Is the triple ""Aspirin causes colonic neoplasm"" supported by the sentence: ""Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.""?",False, +26621273,Aspirin causes diabetic retinopathy,904,"Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.","Is the triple ""Aspirin causes diabetic retinopathy"" supported by the sentence: ""Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.""?",False, +25682183,Aspirin causes Toothache,905,The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.,"Is the triple ""Aspirin causes Toothache"" supported by the sentence: ""The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.""?",False, +24276147,Aspirin causes osteoarthritis,906,"The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.","Is the triple ""Aspirin causes osteoarthritis"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.""?",False, +23603605,Aspirin causes infertility disorder,907,"Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.","Is the triple ""Aspirin causes infertility disorder"" supported by the sentence: ""Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.""?",False, +22149437,Aspirin causes myocardial infarction,908,"In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.","Is the triple ""Aspirin causes myocardial infarction"" supported by the sentence: ""In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.""?",False, +21269587,Aspirin causes preeclampsia,909,This review article will contribute to the in-depth understanding of LDA-induced PE prevention.,"Is the triple ""Aspirin causes preeclampsia"" supported by the sentence: ""This review article will contribute to the in-depth understanding of LDA-induced PE prevention.""?",False, +21190178,Aspirin causes Varicose Ulcer,910,Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.,"Is the triple ""Aspirin causes Varicose Ulcer"" supported by the sentence: ""Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.""?",False, +20967677,Aspirin causes cerebral infarction,911,"The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.","Is the triple ""Aspirin causes cerebral infarction"" supported by the sentence: ""The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.""?",False, +20453125,Aspirin causes squamous cell carcinoma,912,"Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.","Is the triple ""Aspirin causes squamous cell carcinoma"" supported by the sentence: ""Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.""?",False, +20257764,Aspirin causes vascular disorder,913,Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.,"Is the triple ""Aspirin causes vascular disorder"" supported by the sentence: ""Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.""?",False, +18467493,Aspirin causes periodontitis,914,Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.,"Is the triple ""Aspirin causes periodontitis"" supported by the sentence: ""Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.""?",False, +18133593,Aspirin causes acute lung injury,915,Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.,"Is the triple ""Aspirin causes acute lung injury"" supported by the sentence: ""Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.""?",False, +17905974,Aspirin causes mucocutaneous lymph node syndrome,916,Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.,"Is the triple ""Aspirin causes mucocutaneous lymph node syndrome"" supported by the sentence: ""Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.""?",False, +16266546,Aspirin causes cardiovascular disorder,917,BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.,"Is the triple ""Aspirin causes cardiovascular disorder"" supported by the sentence: ""BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.""?",False, +15908394,Aspirin causes arthritic joint disease,918,Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.,"Is the triple ""Aspirin causes arthritic joint disease"" supported by the sentence: ""Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.""?",False, +15782733,Aspirin causes ulcerative colitis,919,Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.,"Is the triple ""Aspirin causes ulcerative colitis"" supported by the sentence: ""Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.""?",False, +15251529,Aspirin causes myocardial ischemia,920,Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.,"Is the triple ""Aspirin causes myocardial ischemia"" supported by the sentence: ""Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.""?",False, +15022291,Aspirin causes pneumonia,921,"BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.","Is the triple ""Aspirin causes pneumonia"" supported by the sentence: ""BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.""?",False, +14953515,Aspirin causes diabetes mellitus,922,"Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.","Is the triple ""Aspirin causes diabetes mellitus"" supported by the sentence: ""Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.""?",False, +14693157,Aspirin causes atrial fibrillation,923,"I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.","Is the triple ""Aspirin causes atrial fibrillation"" supported by the sentence: ""I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.""?",False, +14660024,Aspirin causes ischemic disease,924,C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.,"Is the triple ""Aspirin causes ischemic disease"" supported by the sentence: ""C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.""?",False, +14296178,Aspirin causes type 2 diabetes mellitus,925,Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.,"Is the triple ""Aspirin causes type 2 diabetes mellitus"" supported by the sentence: ""Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.""?",False, +13914591,Aspirin causes digestive system disorder,926,"Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.","Is the triple ""Aspirin causes digestive system disorder"" supported by the sentence: ""Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.""?",False, +13814866,Aspirin causes Fever,927,Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.,"Is the triple ""Aspirin causes Fever"" supported by the sentence: ""Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.""?",False, +13639281,Aspirin causes acute coronary syndrome,928,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes acute coronary syndrome"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, +13639280,Aspirin causes Ischemic stroke,929,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes Ischemic stroke"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, +13405854,Aspirin causes hypertensive disorder,930,"The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.","Is the triple ""Aspirin causes hypertensive disorder"" supported by the sentence: ""The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.""?",False, +13278968,Aspirin causes adult acute respiratory distress syndrome,931,Aspirin-induced non-cardiogenic pulmonary edema.,"Is the triple ""Aspirin causes adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin-induced non-cardiogenic pulmonary edema.""?",False, +11251562,Aspirin causes Pain,932,The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).,"Is the triple ""Aspirin causes Pain"" supported by the sentence: ""The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).""?",False, +10850020,Aspirin causes migraine disorder,933,"When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.","Is the triple ""Aspirin causes migraine disorder"" supported by the sentence: ""When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.""?",False, +10555051,Aspirin causes duodenal ulcer,934,"As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.","Is the triple ""Aspirin causes duodenal ulcer"" supported by the sentence: ""As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.""?",False, +9350599,Aspirin causes active peptic ulcer disease,935,DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.,"Is the triple ""Aspirin causes active peptic ulcer disease"" supported by the sentence: ""DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.""?",False, +9238263,Aspirin causes blood coagulation disease,936,"An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.","Is the triple ""Aspirin causes blood coagulation disease"" supported by the sentence: ""An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.""?",False, +8683872,Aspirin causes stroke disorder,937,"MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.","Is the triple ""Aspirin causes stroke disorder"" supported by the sentence: ""MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.""?",False, +8518235,Aspirin causes peptic ulcer disease,938,Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.,"Is the triple ""Aspirin causes peptic ulcer disease"" supported by the sentence: ""Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.""?",False, +8466167,Aspirin causes Headache,939,(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.,"Is the triple ""Aspirin causes Headache"" supported by the sentence: ""(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.""?",False, +8232293,Aspirin causes Hemorrhage,940,"The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.","Is the triple ""Aspirin causes Hemorrhage"" supported by the sentence: ""The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.""?",False, +7594346,Aspirin causes asthma,941,LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.,"Is the triple ""Aspirin causes asthma"" supported by the sentence: ""LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.""?",False, +7353622,Aspirin causes gastric ulcer,942,BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.,"Is the triple ""Aspirin causes gastric ulcer"" supported by the sentence: ""BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.""?",False, +7227553,Aspirin causes injury,943,"Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.","Is the triple ""Aspirin causes injury"" supported by the sentence: ""Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.""?",False, +26773149,Aspirin affects atrial fibrillation,944,Further studies are needed to clarify the role of aspirin in atrial fibrillation.,"Is the triple ""Aspirin affects atrial fibrillation"" supported by the sentence: ""Further studies are needed to clarify the role of aspirin in atrial fibrillation.""?",False, +26425353,Aspirin affects atherosclerosis,945,Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.""?",False, +26396469,Aspirin affects Dysmenorrhea,946,The effect of aspirin on dysmenorrhea in adolescents.,"Is the triple ""Aspirin affects Dysmenorrhea"" supported by the sentence: ""The effect of aspirin on dysmenorrhea in adolescents.""?",False, +25760183,Aspirin affects thrombophilia due to thrombin defect,947,Effect of aspirin on postoperative venous thrombosis.,"Is the triple ""Aspirin affects thrombophilia due to thrombin defect"" supported by the sentence: ""Effect of aspirin on postoperative venous thrombosis.""?",False, +24559876,Aspirin affects coronary artery disorder,948,"CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.","Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.""?",False, +23119254,Aspirin affects brain aneurysm,949,Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.""?",False, +21758599,Aspirin affects brain aneurysm,950,CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.""?",False, +21116359,Aspirin affects major depressive disorder,951,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, +21116358,Aspirin affects schizophrenia,952,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects schizophrenia"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, +21031382,Aspirin affects neoplasm,953,"Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.""?",False, +20857373,Aspirin affects melanoma,954,"It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.","Is the triple ""Aspirin affects melanoma"" supported by the sentence: ""It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.""?",False, +20741170,Aspirin affects fetal growth restriction,955,Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.,"Is the triple ""Aspirin affects fetal growth restriction"" supported by the sentence: ""Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.""?",False, +20453126,Aspirin affects squamous cell carcinoma,956,"To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.","Is the triple ""Aspirin affects squamous cell carcinoma"" supported by the sentence: ""To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.""?",False, +19190473,Aspirin affects acute lung injury,957,RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.,"Is the triple ""Aspirin affects acute lung injury"" supported by the sentence: ""RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.""?",False, +18874269,Aspirin affects preeclampsia,958,Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.,"Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.""?",False, +18830463,Aspirin affects Varicose Ulcer,959,"To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.","Is the triple ""Aspirin affects Varicose Ulcer"" supported by the sentence: ""To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.""?",False, +18706529,Aspirin affects mucocutaneous lymph node syndrome,960,"Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.","Is the triple ""Aspirin affects mucocutaneous lymph node syndrome"" supported by the sentence: ""Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.""?",False, +18617993,Aspirin affects Sepsis,961,"This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.","Is the triple ""Aspirin affects Sepsis"" supported by the sentence: ""This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.""?",False, +18348076,Aspirin affects Headache,962,"We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).","Is the triple ""Aspirin affects Headache"" supported by the sentence: ""We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).""?",False, +18344374,Aspirin affects bone fracture,963,This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.,"Is the triple ""Aspirin affects bone fracture"" supported by the sentence: ""This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.""?",False, +18277701,Aspirin affects adult acute respiratory distress syndrome,964,"Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.","Is the triple ""Aspirin affects adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.""?",False, +18092588,Aspirin affects Fever,965,"Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.""?",False, +17810437,Aspirin affects migraine disorder,966,"Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.","Is the triple ""Aspirin affects migraine disorder"" supported by the sentence: ""Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.""?",False, +16655533,Aspirin affects stroke disorder,967,Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.""?",False, +16466986,Aspirin affects myocardial ischemia,968,Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).""?",False, +16123563,Aspirin affects digestive system disorder,969,[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].,"Is the triple ""Aspirin affects digestive system disorder"" supported by the sentence: ""[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].""?",False, +15829936,Aspirin affects hypertriglyceridemia,970,Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.,"Is the triple ""Aspirin affects hypertriglyceridemia"" supported by the sentence: ""Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.""?",False, +15667690,Aspirin affects hepatocellular carcinoma,971,Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.,"Is the triple ""Aspirin affects hepatocellular carcinoma"" supported by the sentence: ""Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.""?",False, +15311732,Aspirin affects periodontitis,972,"METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.","Is the triple ""Aspirin affects periodontitis"" supported by the sentence: ""METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.""?",False, +15094783,Aspirin affects diabetic retinopathy,973,Effects of aspirin treatment on diabetic retinopathy.,"Is the triple ""Aspirin affects diabetic retinopathy"" supported by the sentence: ""Effects of aspirin treatment on diabetic retinopathy.""?",False, +13831910,Aspirin affects gastric ulcer,974,The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.,"Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.""?",False, +13734334,Aspirin affects Pregnancy,975,"There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.","Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.""?",False, +13647977,Aspirin affects neoplasm,976,"We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.""?",False, +13624111,Aspirin affects pneumonia,977,OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.,"Is the triple ""Aspirin affects pneumonia"" supported by the sentence: ""OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.""?",False, +13559011,Aspirin affects type 2 diabetes mellitus,978,"Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.","Is the triple ""Aspirin affects type 2 diabetes mellitus"" supported by the sentence: ""Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.""?",False, +13493823,Aspirin affects thrombotic disease,979,Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.,"Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.""?",False, +12884495,Aspirin affects duodenal ulcer,980,"Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.","Is the triple ""Aspirin affects duodenal ulcer"" supported by the sentence: ""Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.""?",False, +12815469,Aspirin affects atherosclerosis,981,Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.""?",False, +12769418,Aspirin affects active peptic ulcer disease,982,The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.""?",False, +12607959,Aspirin affects plasma cell myeloma,983,Does low-dose aspirin have antineoplastic effects in multiple myeloma?,"Is the triple ""Aspirin affects plasma cell myeloma"" supported by the sentence: ""Does low-dose aspirin have antineoplastic effects in multiple myeloma?""?",False, +12446363,Aspirin affects hypertensive disorder,984,Diabetes mellitus and hypertension are relative risk factors of AR and ASR.,"Is the triple ""Aspirin affects hypertensive disorder"" supported by the sentence: ""Diabetes mellitus and hypertension are relative risk factors of AR and ASR.""?",False, +12124867,Aspirin affects heart disorder,985,Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.,"Is the triple ""Aspirin affects heart disorder"" supported by the sentence: ""Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.""?",False, +11661767,Aspirin affects peptic ulcer disease,986,"CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.""?",False, +11474111,Aspirin affects diabetes mellitus,987,We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.,"Is the triple ""Aspirin affects diabetes mellitus"" supported by the sentence: ""We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.""?",False, +11357781,Aspirin affects ischemic disease,988,Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.,"Is the triple ""Aspirin affects ischemic disease"" supported by the sentence: ""Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.""?",False, +11341534,Aspirin affects ulcer disease,989,"Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.""?",False, +11135514,Aspirin affects cerebrovascular disorder,990,Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.,"Is the triple ""Aspirin affects cerebrovascular disorder"" supported by the sentence: ""Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.""?",False, +10875862,Aspirin affects acquired polycythemia vera,991,"Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.","Is the triple ""Aspirin affects acquired polycythemia vera"" supported by the sentence: ""Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.""?",False, +10830878,Aspirin affects Inflammation,992,"These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.""?",False, +10337669,Aspirin affects colorectal neoplasm,993,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Aspirin affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, +10331252,Aspirin affects peptic ulcer disease,994,"Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.""?",False, +10226347,Aspirin affects thrombophilia,995,"Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.","Is the triple ""Aspirin affects thrombophilia"" supported by the sentence: ""Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.""?",False, +10082315,Aspirin affects Pain,996,"Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.","Is the triple ""Aspirin affects Pain"" supported by the sentence: ""Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.""?",False, +10068618,Aspirin affects adenoma,997,CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.,"Is the triple ""Aspirin affects adenoma"" supported by the sentence: ""CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.""?",False, +9766251,Aspirin affects injury,998,Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.,"Is the triple ""Aspirin affects injury"" supported by the sentence: ""Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.""?",False, +9581221,Aspirin affects cataract,999,"Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.","Is the triple ""Aspirin affects cataract"" supported by the sentence: ""Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.""?",False, +9528323,Aspirin affects asthma,1000,We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).,"Is the triple ""Aspirin affects asthma"" supported by the sentence: ""We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).""?",False, +9510044,Aspirin affects transient ischemic attack,1001,This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.,"Is the triple ""Aspirin affects transient ischemic attack"" supported by the sentence: ""This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.""?",False, +9342553,Aspirin affects Salicylic Acid,1002,"METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.""?",False, +9259288,Aspirin affects Fever,1003,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, +9203900,Aspirin affects Hypercholesterolemia,1004,This action of aspirin is blunted in hypercholesterolemia.,"Is the triple ""Aspirin affects Hypercholesterolemia"" supported by the sentence: ""This action of aspirin is blunted in hypercholesterolemia.""?",False, +9160463,Aspirin affects gastric ulcer,1005,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.","Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.""?",False, +9084341,Aspirin affects Ischemic stroke,1006,A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.,"Is the triple ""Aspirin affects Ischemic stroke"" supported by the sentence: ""A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.""?",False, +8650258,Aspirin affects Hemorrhage,1007,"CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.""?",False, +8543326,Aspirin affects active peptic ulcer disease,1008,OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.""?",False, +8290962,Aspirin affects ulcer disease,1009,"Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.""?",False, +8187935,Aspirin affects injury,1010,"Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.","Is the triple ""Aspirin affects injury"" supported by the sentence: ""Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.""?",False, +8173134,Aspirin affects thrombotic disease,1011,"These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.","Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.""?",False, +8169760,Aspirin affects preeclampsia,1012,"These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.","Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.""?",False, +7935107,Aspirin affects prostate cancer,1013,"Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.","Is the triple ""Aspirin affects prostate cancer"" supported by the sentence: ""Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.""?",False, +7920712,Aspirin affects Hemorrhage,1014,"After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.""?",False, +7876600,Aspirin affects Hemorrhage,1015,"CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.""?",False, +7820545,Aspirin affects vascular disorder,1016,The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.,"Is the triple ""Aspirin affects vascular disorder"" supported by the sentence: ""The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.""?",False, +7816175,Aspirin affects Pregnancy,1017,L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.,"Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.""?",False, +7635677,Aspirin affects myocardial ischemia,1018,We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.""?",False, +7478885,Aspirin affects coronary artery disorder,1019,Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.,"Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.""?",False, +7468514,Aspirin affects stroke disorder,1020,A metaregression analysis of the dose-response effect of aspirin on stroke.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""A metaregression analysis of the dose-response effect of aspirin on stroke.""?",False, +7251569,Aspirin affects myocardial infarction,1021,A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.,"Is the triple ""Aspirin affects myocardial infarction"" supported by the sentence: ""A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.""?",False, +7213554,Aspirin affects cardiovascular disorder,1022,"The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.","Is the triple ""Aspirin affects cardiovascular disorder"" supported by the sentence: ""The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.""?",False, +7156429,Aspirin affects Inflammation,1023,"The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.""?",False, +14159165,Aspirin affects Salicylic Acid,1024,"According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.""?",False, +27335099,Aspirin disrupts thrombophilia due to thrombin defect,1025,"In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.","Is the triple ""Aspirin disrupts thrombophilia due to thrombin defect"" supported by the sentence: ""In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.""?",False, +24958273,Aspirin disrupts Fever,1026,"In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.","Is the triple ""Aspirin disrupts Fever"" supported by the sentence: ""In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.""?",False, +24520178,Aspirin disrupts melanoma,1027,"However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).","Is the triple ""Aspirin disrupts melanoma"" supported by the sentence: ""However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).""?",False, +24047967,Aspirin disrupts cardiovascular disorder,1028,"Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.","Is the triple ""Aspirin disrupts cardiovascular disorder"" supported by the sentence: ""Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.""?",False, +22107293,Aspirin disrupts atrial fibrillation,1029,Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.,"Is the triple ""Aspirin disrupts atrial fibrillation"" supported by the sentence: ""Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.""?",False, +22100738,Aspirin disrupts fetal growth restriction,1030,"Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.","Is the triple ""Aspirin disrupts fetal growth restriction"" supported by the sentence: ""Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.""?",False, +22027792,Aspirin disrupts venous thromboembolism,1031,Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.,"Is the triple ""Aspirin disrupts venous thromboembolism"" supported by the sentence: ""Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.""?",False, +21434441,Aspirin disrupts thrombophilia,1032,"Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.","Is the triple ""Aspirin disrupts thrombophilia"" supported by the sentence: ""Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.""?",False, +20385507,Aspirin disrupts essential thrombocythemia,1033,"However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.","Is the triple ""Aspirin disrupts essential thrombocythemia"" supported by the sentence: ""However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.""?",False, +19437129,Aspirin disrupts Sepsis,1034,"This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).","Is the triple ""Aspirin disrupts Sepsis"" supported by the sentence: ""This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).""?",False, +19421638,Aspirin disrupts pneumonia,1035,"CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.","Is the triple ""Aspirin disrupts pneumonia"" supported by the sentence: ""CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.""?",False, +19318532,Aspirin disrupts vascular disorder,1036,These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.,"Is the triple ""Aspirin disrupts vascular disorder"" supported by the sentence: ""These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.""?",False, +18604728,Aspirin disrupts type 2 diabetes mellitus,1037,"Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.","Is the triple ""Aspirin disrupts type 2 diabetes mellitus"" supported by the sentence: ""Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.""?",False, +18599969,Aspirin disrupts arthritic joint disease,1038,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.","Is the triple ""Aspirin disrupts arthritic joint disease"" supported by the sentence: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?",False, +18445880,Aspirin disrupts ovarian cancer,1039,"Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.","Is the triple ""Aspirin disrupts ovarian cancer"" supported by the sentence: ""Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.""?",False, +18225861,Aspirin disrupts Hemorrhage,1040,"Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.","Is the triple ""Aspirin disrupts Hemorrhage"" supported by the sentence: ""Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.""?",False, +18203584,Aspirin disrupts brain aneurysm,1041,Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.,"Is the triple ""Aspirin disrupts brain aneurysm"" supported by the sentence: ""Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.""?",False, +17476286,Aspirin disrupts Fatigue,1042,"In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.","Is the triple ""Aspirin disrupts Fatigue"" supported by the sentence: ""In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.""?",False, +17225706,Aspirin disrupts transient ischemic attack,1043,The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.,"Is the triple ""Aspirin disrupts transient ischemic attack"" supported by the sentence: ""The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.""?",False, +16676314,Aspirin disrupts ulcer disease,1044,"Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.","Is the triple ""Aspirin disrupts ulcer disease"" supported by the sentence: ""Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.""?",False, +16484307,Aspirin disrupts acute lung injury,1045,"METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.","Is the triple ""Aspirin disrupts acute lung injury"" supported by the sentence: ""METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.""?",False, +14296080,Aspirin disrupts Pregnancy,1046,"Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.","Is the triple ""Aspirin disrupts Pregnancy"" supported by the sentence: ""Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.""?",False, +14068900,Aspirin disrupts active peptic ulcer disease,1047,"In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.","Is the triple ""Aspirin disrupts active peptic ulcer disease"" supported by the sentence: ""In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.""?",False, +13892678,Aspirin disrupts breast neoplasm,1048,Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.,"Is the triple ""Aspirin disrupts breast neoplasm"" supported by the sentence: ""Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.""?",False, +13449558,Aspirin disrupts colorectal neoplasm,1049,"BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.","Is the triple ""Aspirin disrupts colorectal neoplasm"" supported by the sentence: ""BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.""?",False, +12947740,Aspirin disrupts diabetic retinopathy,1050,"It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.","Is the triple ""Aspirin disrupts diabetic retinopathy"" supported by the sentence: ""It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.""?",False, +12815470,Aspirin disrupts atherosclerosis,1051,"CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.","Is the triple ""Aspirin disrupts atherosclerosis"" supported by the sentence: ""CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.""?",False, +12714476,Aspirin disrupts cataract,1052,Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.,"Is the triple ""Aspirin disrupts cataract"" supported by the sentence: ""Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.""?",False, +12478523,Aspirin disrupts preeclampsia,1053,Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?,"Is the triple ""Aspirin disrupts preeclampsia"" supported by the sentence: ""Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?""?",False, +12450426,Aspirin disrupts Barrett esophagus,1054,"Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].","Is the triple ""Aspirin disrupts Barrett esophagus"" supported by the sentence: ""Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].""?",False, +12023670,Aspirin disrupts hypertensive disorder,1055,The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.,"Is the triple ""Aspirin disrupts hypertensive disorder"" supported by the sentence: ""The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.""?",False, +11827133,Aspirin disrupts diabetes mellitus,1056,"Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.","Is the triple ""Aspirin disrupts diabetes mellitus"" supported by the sentence: ""Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.""?",False, +10318928,Aspirin disrupts Myalgia,1057,"RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).","Is the triple ""Aspirin disrupts Myalgia"" supported by the sentence: ""RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).""?",False, +9742254,Aspirin disrupts adenoma,1058,"BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.","Is the triple ""Aspirin disrupts adenoma"" supported by the sentence: ""BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.""?",False, +9148614,Aspirin disrupts neoplasm,1059,"Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.","Is the triple ""Aspirin disrupts neoplasm"" supported by the sentence: ""Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.""?",False, +8526818,Aspirin disrupts myocardial infarction,1060,"Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).","Is the triple ""Aspirin disrupts myocardial infarction"" supported by the sentence: ""Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).""?",False, +7995298,Aspirin disrupts Inflammation,1061,RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.,"Is the triple ""Aspirin disrupts Inflammation"" supported by the sentence: ""RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.""?",False, +7878103,Aspirin disrupts prostate cancer,1062,"Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).","Is the triple ""Aspirin disrupts prostate cancer"" supported by the sentence: ""Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).""?",False, +7775480,Aspirin disrupts Pain,1063,"The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.","Is the triple ""Aspirin disrupts Pain"" supported by the sentence: ""The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.""?",False, +7723340,Aspirin disrupts stroke disorder,1064,"Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.","Is the triple ""Aspirin disrupts stroke disorder"" supported by the sentence: ""Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.""?",False, +7712646,Aspirin disrupts coronary artery disorder,1065,Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.,"Is the triple ""Aspirin disrupts coronary artery disorder"" supported by the sentence: ""Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.""?",False, +7261879,Aspirin disrupts thrombotic disease,1066,"In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.","Is the triple ""Aspirin disrupts thrombotic disease"" supported by the sentence: ""In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.""?",False, +24597938,Aspirin prevents thrombophilia,1067,Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.,"Is the triple ""Aspirin prevents thrombophilia"" supported by the sentence: ""Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.""?",False, +24091248,Aspirin prevents disseminated intravascular coagulation,1068,Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.,"Is the triple ""Aspirin prevents disseminated intravascular coagulation"" supported by the sentence: ""Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.""?",False, +24015329,Aspirin prevents neoplasm of esophagus,1069,"Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.","Is the triple ""Aspirin prevents neoplasm of esophagus"" supported by the sentence: ""Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.""?",False, +23042755,Aspirin prevents brain aneurysm,1070,BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.,"Is the triple ""Aspirin prevents brain aneurysm"" supported by the sentence: ""BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.""?",False, +22291835,Aspirin prevents Hemorrhage,1071,"CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.","Is the triple ""Aspirin prevents Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.""?",False, +21962376,Aspirin prevents venous thromboembolism,1072,Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.,"Is the triple ""Aspirin prevents venous thromboembolism"" supported by the sentence: ""Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.""?",False, +21587985,Aspirin prevents blood coagulation disease,1073,Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.,"Is the triple ""Aspirin prevents blood coagulation disease"" supported by the sentence: ""Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.""?",False, +21116357,Aspirin prevents schizophrenia,1074,The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.,"Is the triple ""Aspirin prevents schizophrenia"" supported by the sentence: ""The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.""?",False, +20356983,Aspirin prevents acute lung injury,1075,"Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).","Is the triple ""Aspirin prevents acute lung injury"" supported by the sentence: ""Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).""?",False, +20189716,Aspirin prevents brain infarction,1076,"We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.","Is the triple ""Aspirin prevents brain infarction"" supported by the sentence: ""We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.""?",False, +18414184,Aspirin prevents multiple sclerosis,1077,"Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.","Is the triple ""Aspirin prevents multiple sclerosis"" supported by the sentence: ""Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.""?",False, +18344373,Aspirin prevents bone fracture,1078,"If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.","Is the triple ""Aspirin prevents bone fracture"" supported by the sentence: ""If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.""?",False, +17911903,Aspirin prevents adult acute respiratory distress syndrome,1079,"Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.","Is the triple ""Aspirin prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.""?",False, +17240995,Aspirin prevents hepatocellular carcinoma,1080,Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).,"Is the triple ""Aspirin prevents hepatocellular carcinoma"" supported by the sentence: ""Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).""?",False, +16163718,Aspirin prevents Sepsis,1081,The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.,"Is the triple ""Aspirin prevents Sepsis"" supported by the sentence: ""The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.""?",False, +15608454,Aspirin prevents squamous cell carcinoma,1082,"CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.","Is the triple ""Aspirin prevents squamous cell carcinoma"" supported by the sentence: ""CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.""?",False, +14796348,Aspirin prevents arthritic joint disease,1083,"Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.","Is the triple ""Aspirin prevents arthritic joint disease"" supported by the sentence: ""Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.""?",False, +14183452,Aspirin prevents pneumonia,1084,Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.,"Is the triple ""Aspirin prevents pneumonia"" supported by the sentence: ""Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.""?",False, +13992680,Aspirin prevents diabetes mellitus,1085,We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.,"Is the triple ""Aspirin prevents diabetes mellitus"" supported by the sentence: ""We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.""?",False, +13992679,Aspirin prevents type 2 diabetes mellitus,1086,CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.,"Is the triple ""Aspirin prevents type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.""?",False, +13770407,Aspirin prevents diabetic retinopathy,1087,"According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.","Is the triple ""Aspirin prevents diabetic retinopathy"" supported by the sentence: ""According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.""?",False, +13624060,Aspirin prevents injury,1088,The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.,"Is the triple ""Aspirin prevents injury"" supported by the sentence: ""The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.""?",False, +13536062,Aspirin prevents non-small cell lung carcinoma,1089,CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.,"Is the triple ""Aspirin prevents non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.""?",False, +13041448,Aspirin prevents atrial fibrillation,1090,"Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.","Is the triple ""Aspirin prevents atrial fibrillation"" supported by the sentence: ""Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.""?",False, +12791249,Aspirin prevents asthma,1091,"CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.","Is the triple ""Aspirin prevents asthma"" supported by the sentence: ""CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.""?",False, +12594676,Aspirin prevents Fatigue,1092,Aspirin reduces MS fatigue in some patients.,"Is the triple ""Aspirin prevents Fatigue"" supported by the sentence: ""Aspirin reduces MS fatigue in some patients.""?",False, +12361944,Aspirin prevents active peptic ulcer disease,1093,CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.,"Is the triple ""Aspirin prevents active peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.""?",False, +12273189,Aspirin prevents Myalgia,1094,BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.,"Is the triple ""Aspirin prevents Myalgia"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.""?",False, +11593026,Aspirin prevents colorectal neoplasm,1095,Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.,"Is the triple ""Aspirin prevents colorectal neoplasm"" supported by the sentence: ""Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.""?",False, +11289178,Aspirin prevents migraine disorder,1096,"The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.","Is the triple ""Aspirin prevents migraine disorder"" supported by the sentence: ""The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.""?",False, +11042545,Aspirin prevents Barrett esophagus,1097,"BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.","Is the triple ""Aspirin prevents Barrett esophagus"" supported by the sentence: ""BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.""?",False, +10366572,Aspirin prevents cerebrovascular disorder,1098,"Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.","Is the triple ""Aspirin prevents cerebrovascular disorder"" supported by the sentence: ""Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.""?",False, +10293726,Aspirin prevents prostate cancer,1099,"The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.","Is the triple ""Aspirin prevents prostate cancer"" supported by the sentence: ""The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.""?",False, +10185706,Aspirin prevents colonic neoplasm,1100,Can resistant starch and/or aspirin prevent the development of colonic neoplasia?,"Is the triple ""Aspirin prevents colonic neoplasm"" supported by the sentence: ""Can resistant starch and/or aspirin prevent the development of colonic neoplasia?""?",False, +10099399,Aspirin prevents atherosclerosis,1101,Aspirin treatment reduced the development of atherosclerosis by approximately 47%.,"Is the triple ""Aspirin prevents atherosclerosis"" supported by the sentence: ""Aspirin treatment reduced the development of atherosclerosis by approximately 47%.""?",False, +10096705,Aspirin prevents cerebral infarction,1102,"Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.","Is the triple ""Aspirin prevents cerebral infarction"" supported by the sentence: ""Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.""?",False, +10004143,Aspirin prevents blindness (disorder),1103,"Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.","Is the triple ""Aspirin prevents blindness (disorder)"" supported by the sentence: ""Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.""?",False, +9665356,Aspirin prevents hypertensive disorder,1104,CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.,"Is the triple ""Aspirin prevents hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.""?",False, +9388878,Aspirin prevents coronary artery disorder,1105,[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].,"Is the triple ""Aspirin prevents coronary artery disorder"" supported by the sentence: ""[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].""?",False, +9150304,Aspirin prevents habitual spontaneous abortion,1106,"Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.","Is the triple ""Aspirin prevents habitual spontaneous abortion"" supported by the sentence: ""Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.""?",False, +8853513,Aspirin prevents gastric ulcer,1107,"All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.","Is the triple ""Aspirin prevents gastric ulcer"" supported by the sentence: ""All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.""?",False, +8755758,Aspirin prevents vascular disorder,1108,"Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.","Is the triple ""Aspirin prevents vascular disorder"" supported by the sentence: ""Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.""?",False, +8494726,Aspirin prevents ulcer disease,1109,"Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.","Is the triple ""Aspirin prevents ulcer disease"" supported by the sentence: ""Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.""?",False, +8347839,Aspirin prevents peptic ulcer disease,1110,"METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.","Is the triple ""Aspirin prevents peptic ulcer disease"" supported by the sentence: ""METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.""?",False, +8325441,Aspirin prevents ischemic disease,1111,Peri-operative aspirin can prevent post-operative ischemia and thrombosis.,"Is the triple ""Aspirin prevents ischemic disease"" supported by the sentence: ""Peri-operative aspirin can prevent post-operative ischemia and thrombosis.""?",False, +7877588,Aspirin prevents cardiovascular disorder,1112,"METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.","Is the triple ""Aspirin prevents cardiovascular disorder"" supported by the sentence: ""METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.""?",False, +7852267,Aspirin prevents Headache,1113,"Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.","Is the triple ""Aspirin prevents Headache"" supported by the sentence: ""Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.""?",False, +7716613,Aspirin prevents neoplasm,1114,"Furthermore, aspirin decreased the total tumors (P < 0.05).","Is the triple ""Aspirin prevents neoplasm"" supported by the sentence: ""Furthermore, aspirin decreased the total tumors (P < 0.05).""?",False, +7603499,Aspirin prevents myocardial ischemia,1115,Low dose warfarin and aspirin in preventing IHD.,"Is the triple ""Aspirin prevents myocardial ischemia"" supported by the sentence: ""Low dose warfarin and aspirin in preventing IHD.""?",False, +7487700,Aspirin prevents Inflammation,1116,"Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.","Is the triple ""Aspirin prevents Inflammation"" supported by the sentence: ""Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.""?",False, +7457050,Aspirin prevents peripheral vascular disease,1117,"Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.","Is the triple ""Aspirin prevents peripheral vascular disease"" supported by the sentence: ""Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.""?",False, +7455467,Aspirin prevents Ischemic stroke,1118,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents Ischemic stroke"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, +7455466,Aspirin prevents stroke disorder,1119,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents stroke disorder"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, +7455465,Aspirin prevents transient ischemic attack,1120,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents transient ischemic attack"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, +7419265,Aspirin prevents heart disorder,1121,"RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.","Is the triple ""Aspirin prevents heart disorder"" supported by the sentence: ""RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.""?",False, +7368248,Aspirin prevents thrombotic disease,1122,Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.,"Is the triple ""Aspirin prevents thrombotic disease"" supported by the sentence: ""Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.""?",False, +7317027,Aspirin prevents preeclampsia,1123,Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.,"Is the triple ""Aspirin prevents preeclampsia"" supported by the sentence: ""Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.""?",False, +7275741,Aspirin prevents acute coronary syndrome,1124,"CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.","Is the triple ""Aspirin prevents acute coronary syndrome"" supported by the sentence: ""CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.""?",False, +7264064,Aspirin prevents Pain,1125,Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.,"Is the triple ""Aspirin prevents Pain"" supported by the sentence: ""Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.""?",False, +7196018,Aspirin prevents myocardial infarction,1126,"BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.","Is the triple ""Aspirin prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.""?",False, +7159192,Aspirin prevents fetal growth restriction,1127,"If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.","Is the triple ""Aspirin prevents fetal growth restriction"" supported by the sentence: ""If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.""?",False, +7110859,Aspirin prevents thrombophilia due to thrombin defect,1128,[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].,"Is the triple ""Aspirin prevents thrombophilia due to thrombin defect"" supported by the sentence: ""[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].""?",False, +22126985,Aspirin exacerbates gastric ulcer,1129,"Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.","Is the triple ""Aspirin exacerbates gastric ulcer"" supported by the sentence: ""Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.""?",False, +21411566,Aspirin exacerbates macular degeneration,1130,Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?,"Is the triple ""Aspirin exacerbates macular degeneration"" supported by the sentence: ""Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?""?",False, +21359197,Aspirin exacerbates acute coronary syndrome,1131,Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.,"Is the triple ""Aspirin exacerbates acute coronary syndrome"" supported by the sentence: ""Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.""?",False, +26115547,Aspirin predisposes cerebral infarction,1132,"Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.","Is the triple ""Aspirin predisposes cerebral infarction"" supported by the sentence: ""Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.""?",False, +25254777,Aspirin predisposes essential thrombocythemia,1133,"Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.","Is the triple ""Aspirin predisposes essential thrombocythemia"" supported by the sentence: ""Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.""?",False, +23315977,Aspirin predisposes brain aneurysm,1134,The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.,"Is the triple ""Aspirin predisposes brain aneurysm"" supported by the sentence: ""The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.""?",False, +21525767,Aspirin predisposes Fever,1135,Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).,"Is the triple ""Aspirin predisposes Fever"" supported by the sentence: ""Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).""?",False, +21487721,Aspirin predisposes Hemorrhage,1136,"The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).","Is the triple ""Aspirin predisposes Hemorrhage"" supported by the sentence: ""The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).""?",False, +20679052,Aspirin predisposes blood coagulation disease,1137,"Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.","Is the triple ""Aspirin predisposes blood coagulation disease"" supported by the sentence: ""Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.""?",False, +20234206,Aspirin predisposes hepatocellular carcinoma,1138,The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.,"Is the triple ""Aspirin predisposes hepatocellular carcinoma"" supported by the sentence: ""The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.""?",False, +20155873,Aspirin predisposes placental insufficiency,1139,"There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.","Is the triple ""Aspirin predisposes placental insufficiency"" supported by the sentence: ""There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.""?",False, +19346376,Aspirin predisposes chronic renal failure syndrome,1140,The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.,"Is the triple ""Aspirin predisposes chronic renal failure syndrome"" supported by the sentence: ""The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.""?",False, +18235965,Aspirin predisposes macular degeneration,1141,[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].,"Is the triple ""Aspirin predisposes macular degeneration"" supported by the sentence: ""[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].""?",False, +17872103,Aspirin predisposes atrial fibrillation,1142,"The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.","Is the triple ""Aspirin predisposes atrial fibrillation"" supported by the sentence: ""The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.""?",False, +17123250,Aspirin predisposes acute coronary syndrome,1143,"In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.","Is the triple ""Aspirin predisposes acute coronary syndrome"" supported by the sentence: ""In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.""?",False, +16813141,Aspirin predisposes melanoma,1144,"In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.","Is the triple ""Aspirin predisposes melanoma"" supported by the sentence: ""In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.""?",False, +16162173,Aspirin predisposes ulcerative colitis,1145,"Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.","Is the triple ""Aspirin predisposes ulcerative colitis"" supported by the sentence: ""Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.""?",False, +15461534,Aspirin predisposes gastric ulcer,1146,Aspirin specifically predisposes to gastric ulcer.,"Is the triple ""Aspirin predisposes gastric ulcer"" supported by the sentence: ""Aspirin specifically predisposes to gastric ulcer.""?",False, +14856258,Aspirin predisposes neoplasm of esophagus,1147,"BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.","Is the triple ""Aspirin predisposes neoplasm of esophagus"" supported by the sentence: ""BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.""?",False, +14426809,Aspirin predisposes neoplasm,1148,NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.,"Is the triple ""Aspirin predisposes neoplasm"" supported by the sentence: ""NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.""?",False, +14234947,Aspirin predisposes diabetes mellitus,1149,"This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.","Is the triple ""Aspirin predisposes diabetes mellitus"" supported by the sentence: ""This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.""?",False, +14126301,Aspirin predisposes cerebrovascular disorder,1150,"We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).","Is the triple ""Aspirin predisposes cerebrovascular disorder"" supported by the sentence: ""We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).""?",False, +14052964,Aspirin predisposes Inflammation,1151,"Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).","Is the triple ""Aspirin predisposes Inflammation"" supported by the sentence: ""Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).""?",False, +14015029,Aspirin predisposes transient ischemic attack,1152,"When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.","Is the triple ""Aspirin predisposes transient ischemic attack"" supported by the sentence: ""When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.""?",False, +13644771,Aspirin predisposes asthma,1153,A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.,"Is the triple ""Aspirin predisposes asthma"" supported by the sentence: ""A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.""?",False, +13536064,Aspirin predisposes non-small cell lung carcinoma,1154,Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.,"Is the triple ""Aspirin predisposes non-small cell lung carcinoma"" supported by the sentence: ""Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.""?",False, +13299957,Aspirin predisposes ovarian cancer,1155,Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.,"Is the triple ""Aspirin predisposes ovarian cancer"" supported by the sentence: ""Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.""?",False, +12673405,Aspirin predisposes bone fracture,1156,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Aspirin predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, +12382415,Aspirin predisposes colorectal neoplasm,1157,"AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Aspirin predisposes colorectal neoplasm"" supported by the sentence: ""AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).""?",False, +11071059,Aspirin predisposes injury,1158,"Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.","Is the triple ""Aspirin predisposes injury"" supported by the sentence: ""Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.""?",False, +10962122,Aspirin predisposes ischemic disease,1159,"The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.","Is the triple ""Aspirin predisposes ischemic disease"" supported by the sentence: ""The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.""?",False, +10547299,Aspirin predisposes coronary artery disorder,1160,"Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.","Is the triple ""Aspirin predisposes coronary artery disorder"" supported by the sentence: ""Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.""?",False, +10337650,Aspirin predisposes adenoma,1161,CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.,"Is the triple ""Aspirin predisposes adenoma"" supported by the sentence: ""CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.""?",False, +9857077,Aspirin predisposes vascular disorder,1162,"Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.","Is the triple ""Aspirin predisposes vascular disorder"" supported by the sentence: ""Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.""?",False, +9535755,Aspirin predisposes thrombotic disease,1163,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes thrombotic disease"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, +9535754,Aspirin predisposes hypertensive disorder,1164,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes hypertensive disorder"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, +9491661,Aspirin predisposes cardiovascular disorder,1165,"In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).","Is the triple ""Aspirin predisposes cardiovascular disorder"" supported by the sentence: ""In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).""?",False, +9477464,Aspirin predisposes prostate cancer,1166,"Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).","Is the triple ""Aspirin predisposes prostate cancer"" supported by the sentence: ""Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).""?",False, +9404829,Aspirin predisposes ulcer disease,1167,"Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.","Is the triple ""Aspirin predisposes ulcer disease"" supported by the sentence: ""Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.""?",False, +8850172,Aspirin predisposes myocardial ischemia,1168,"Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.","Is the triple ""Aspirin predisposes myocardial ischemia"" supported by the sentence: ""Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.""?",False, +8763743,Aspirin predisposes thrombophilia due to thrombin defect,1169,The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.,"Is the triple ""Aspirin predisposes thrombophilia due to thrombin defect"" supported by the sentence: ""The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.""?",False, +8545255,Aspirin predisposes Ischemic stroke,1170,"When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.","Is the triple ""Aspirin predisposes Ischemic stroke"" supported by the sentence: ""When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.""?",False, +7865543,Aspirin predisposes Headache,1171,We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.,"Is the triple ""Aspirin predisposes Headache"" supported by the sentence: ""We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.""?",False, +7858710,Aspirin predisposes myocardial infarction,1172,"In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.","Is the triple ""Aspirin predisposes myocardial infarction"" supported by the sentence: ""In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.""?",False, +7667039,Aspirin predisposes preeclampsia,1173,"However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.","Is the triple ""Aspirin predisposes preeclampsia"" supported by the sentence: ""However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.""?",False, +7659453,Aspirin predisposes stroke disorder,1174,RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.,"Is the triple ""Aspirin predisposes stroke disorder"" supported by the sentence: ""RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.""?",False, +7653535,Aspirin predisposes peptic ulcer disease,1175,"BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.","Is the triple ""Aspirin predisposes peptic ulcer disease"" supported by the sentence: ""BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.""?",False, +7596288,Aspirin predisposes atherosclerosis,1176,"OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.","Is the triple ""Aspirin predisposes atherosclerosis"" supported by the sentence: ""OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.""?",False, +7078619,Aspirin predisposes active peptic ulcer disease,1177,Risk of major gastrointestinal bleeding with aspirin.,"Is the triple ""Aspirin predisposes active peptic ulcer disease"" supported by the sentence: ""Risk of major gastrointestinal bleeding with aspirin.""?",False, +23297288,Vemurafenib prevents neoplasm,1178,Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.,"Is the triple ""Vemurafenib prevents neoplasm"" supported by the sentence: ""Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.""?",False, +22851133,Dabrafenib related to melanoma,1179,"KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.","Is the triple ""Dabrafenib related to melanoma"" supported by the sentence: ""KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.""?",False, +18622575,Sodium heparin related to PROTAMINE SULFATE,1180,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, +18622575,Sodium heparin related to PROTAMINE SULFATE,1181,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, +26359747,Sodium heparin related to PROTAMINE SULFATE,1182,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, +26359747,Sodium heparin related to PROTAMINE SULFATE,1183,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, +24697302,Sodium heparin has part PROTAMINE SULFATE,1184,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, +24697302,Sodium heparin has part PROTAMINE SULFATE,1185,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, +10513644,Sodium heparin coexists with PROTAMINE SULFATE,1186,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, +10513644,Sodium heparin coexists with PROTAMINE SULFATE,1187,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, +15306394,Sodium heparin coexists with PROTAMINE SULFATE,1188,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, +15306394,Sodium heparin coexists with PROTAMINE SULFATE,1189,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, +10518221,Sodium heparin physically interacts with PROTAMINE SULFATE,1190,[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].""?",False, +9906740,Sodium heparin physically interacts with PROTAMINE SULFATE,1191,Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.""?",False, +8278260,Sodium heparin affects PROTAMINE SULFATE,1192,Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.,"Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.""?",False, +9085295,Sodium heparin affects PROTAMINE SULFATE,1193,"One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.","Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.""?",False, +25915149,Sodium monofluorophosphate related to dental caries,1194,The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.,"Is the triple ""Sodium monofluorophosphate related to dental caries"" supported by the sentence: ""The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.""?",False, +25861359,Sodium monofluorophosphate disrupts allergic disease,1195,Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.,"Is the triple ""Sodium monofluorophosphate disrupts allergic disease"" supported by the sentence: ""Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.""?",False, +19241020,Sodium Fluoride related to gingivitis,1196,This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.,"Is the triple ""Sodium Fluoride related to gingivitis"" supported by the sentence: ""This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.""?",False, +17448182,Sodium Fluoride related to aortic valve stenosis,1197,BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.,"Is the triple ""Sodium Fluoride related to aortic valve stenosis"" supported by the sentence: ""BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.""?",False, +9111981,Sodium Fluoride related to dental caries,1198,This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.,"Is the triple ""Sodium Fluoride related to dental caries"" supported by the sentence: ""This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.""?",False, +25583763,Sodium Fluoride causes dental fluorosis,1199,"The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.","Is the triple ""Sodium Fluoride causes dental fluorosis"" supported by the sentence: ""The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.""?",False, +23780312,Sodium Fluoride affects dental caries,1200,OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.,"Is the triple ""Sodium Fluoride affects dental caries"" supported by the sentence: ""OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.""?",False, +18846793,Sodium Fluoride affects allergic disease,1201,"At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).","Is the triple ""Sodium Fluoride affects allergic disease"" supported by the sentence: ""At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).""?",False, +25986070,Sodium Fluoride disrupts allergic disease,1202,"In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.","Is the triple ""Sodium Fluoride disrupts allergic disease"" supported by the sentence: ""In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.""?",False, +14286543,Sodium Fluoride prevents gingivitis,1203,"Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.","Is the triple ""Sodium Fluoride prevents gingivitis"" supported by the sentence: ""Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.""?",False, +10538561,Sodium Fluoride prevents periodontal disorder,1204,Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.,"Is the triple ""Sodium Fluoride prevents periodontal disorder"" supported by the sentence: ""Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.""?",False, +10425615,Sodium Fluoride prevents dental caries,1205,Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.,"Is the triple ""Sodium Fluoride prevents dental caries"" supported by the sentence: ""Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.""?",False, +19971424,Rifaximin related to irritable bowel syndrome,1206,"In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.","Is the triple ""Rifaximin related to irritable bowel syndrome"" supported by the sentence: ""In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.""?",False, +17053293,Rifaximin related to hepatic encephalopathy,1207,Rifaximin and lactulose have shown to be effective in HE.,"Is the triple ""Rifaximin related to hepatic encephalopathy"" supported by the sentence: ""Rifaximin and lactulose have shown to be effective in HE.""?",False, +18714048,Rifaximin causes irritable bowel syndrome,1208,"Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.","Is the triple ""Rifaximin causes irritable bowel syndrome"" supported by the sentence: ""Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.""?",False, +8925773,Rifaximin causes diarrheal disease,1209,"In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.","Is the triple ""Rifaximin causes diarrheal disease"" supported by the sentence: ""In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.""?",False, +25434952,Rifaximin affects alcoholic hepatitis,1210,"Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.","Is the triple ""Rifaximin affects alcoholic hepatitis"" supported by the sentence: ""Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.""?",False, +24257624,Rifaximin affects Infection,1211,"Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).","Is the triple ""Rifaximin affects Infection"" supported by the sentence: ""Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).""?",False, +20149851,Rifaximin affects Crohn disease,1212,"In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.","Is the triple ""Rifaximin affects Crohn disease"" supported by the sentence: ""In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.""?",False, +19665399,Rifaximin affects diverticulitis,1213,The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.,"Is the triple ""Rifaximin affects diverticulitis"" supported by the sentence: ""The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.""?",False, +18685028,Rifaximin affects irritable bowel syndrome,1214,AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.,"Is the triple ""Rifaximin affects irritable bowel syndrome"" supported by the sentence: ""AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.""?",False, +16575444,Rifaximin affects hepatic encephalopathy,1215,Rifaximin may have a dramatic effect on hepatic encephalopathy.,"Is the triple ""Rifaximin affects hepatic encephalopathy"" supported by the sentence: ""Rifaximin may have a dramatic effect on hepatic encephalopathy.""?",False, +21278571,Rifaximin prevents alcoholic hepatitis,1216,"In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.","Is the triple ""Rifaximin prevents alcoholic hepatitis"" supported by the sentence: ""In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.""?",False, +16143515,Rifaximin prevents diverticulitis,1217,No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.,"Is the triple ""Rifaximin prevents diverticulitis"" supported by the sentence: ""No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.""?",False, +15134586,Rifaximin prevents hepatic encephalopathy,1218,Gut instinct: rifaximin for the prevention of hepatic encephalopathy.,"Is the triple ""Rifaximin prevents hepatic encephalopathy"" supported by the sentence: ""Gut instinct: rifaximin for the prevention of hepatic encephalopathy.""?",False, +11830138,Rifaximin prevents irritable bowel syndrome,1219,Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.,"Is the triple ""Rifaximin prevents irritable bowel syndrome"" supported by the sentence: ""Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.""?",False, +11830137,Rifaximin prevents diarrheal disease,1220,A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.,"Is the triple ""Rifaximin prevents diarrheal disease"" supported by the sentence: ""A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.""?",False, +15717459,Rifaximin predisposes hepatic encephalopathy,1221,This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.,"Is the triple ""Rifaximin predisposes hepatic encephalopathy"" supported by the sentence: ""This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.""?",False, +25706307,Glycine related to cystic fibrosis,1222,Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.,"Is the triple ""Glycine related to cystic fibrosis"" supported by the sentence: ""Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.""?",False, +20102524,Glycine related to psychotic disorder,1223,"Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.","Is the triple ""Glycine related to psychotic disorder"" supported by the sentence: ""Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.""?",False, +17514096,Glycine related to hypertensive disorder,1224,CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.,"Is the triple ""Glycine related to hypertensive disorder"" supported by the sentence: ""CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.""?",False, +13080824,Glycine related to Alzheimer disease,1225,We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.,"Is the triple ""Glycine related to Alzheimer disease"" supported by the sentence: ""We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.""?",False, +12589996,Glycine related to nutritional disorder,1226,Glycine production in severe childhood undernutrition.,"Is the triple ""Glycine related to nutritional disorder"" supported by the sentence: ""Glycine production in severe childhood undernutrition.""?",False, +7298031,Glycine related to schizophrenia,1227,"Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.","Is the triple ""Glycine related to schizophrenia"" supported by the sentence: ""Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.""?",False, +17397486,Glycine causes Cognitive impairment,1228,"The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.","Is the triple ""Glycine causes Cognitive impairment"" supported by the sentence: ""The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.""?",False, +17125423,Glycine affects asthma,1229,"However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).","Is the triple ""Glycine affects asthma"" supported by the sentence: ""However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).""?",False, +7530162,Glycine affects schizophrenia,1230,"To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.","Is the triple ""Glycine affects schizophrenia"" supported by the sentence: ""To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.""?",False, +12589998,Glycine produces nutritional disorder,1231,OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.,"Is the triple ""Glycine produces nutritional disorder"" supported by the sentence: ""OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.""?",False, +16845009,Glycine disrupts Alzheimer disease,1232,"[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.","Is the triple ""Glycine disrupts Alzheimer disease"" supported by the sentence: ""[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.""?",False, +12278394,Glycine prevents hypertensive disorder,1233,"The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.","Is the triple ""Glycine prevents hypertensive disorder"" supported by the sentence: ""The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.""?",False, +15546112,Glycine predisposes asthma,1234,"Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.","Is the triple ""Glycine predisposes asthma"" supported by the sentence: ""Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.""?",False, +16711324,Sorbitol related to injury,1235,"CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.","Is the triple ""Sorbitol related to injury"" supported by the sentence: ""CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.""?",False, +10684679,Sorbitol related to constipation disorder,1236,[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].,"Is the triple ""Sorbitol related to constipation disorder"" supported by the sentence: ""[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].""?",False, +20821510,Sorbitol causes constipation disorder,1237,"However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.","Is the triple ""Sorbitol causes constipation disorder"" supported by the sentence: ""However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.""?",False, +15564538,Sorbitol causes injury,1238,"Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.","Is the triple ""Sorbitol causes injury"" supported by the sentence: ""Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.""?",False, +17658899,Sorbitol affects osteoarthritis,1239,"CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.","Is the triple ""Sorbitol affects osteoarthritis"" supported by the sentence: ""CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.""?",False, +26106951,Sorbitol prevents injury,1240,"Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.","Is the triple ""Sorbitol prevents injury"" supported by the sentence: ""Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.""?",False, +10478248,Foscarnet affects cytomegalovirus infection,1241,We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.,"Is the triple ""Foscarnet affects cytomegalovirus infection"" supported by the sentence: ""We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.""?",False, +10481132,Foscarnet prevents cytomegalovirus infection,1242,The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.,"Is the triple ""Foscarnet prevents cytomegalovirus infection"" supported by the sentence: ""The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.""?",False, +22857734,Atogepant prevents migraine disorder,1243,"Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.","Is the triple ""Atogepant prevents migraine disorder"" supported by the sentence: ""Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.""?",False, +25325960,Rimegepant prevents migraine disorder,1244,"As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.","Is the triple ""Rimegepant prevents migraine disorder"" supported by the sentence: ""As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.""?",False, +21939131,Rimegepant prevents Pain,1245,"The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.","Is the triple ""Rimegepant prevents Pain"" supported by the sentence: ""The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.""?",False, +10553741,ATROPINE related to poisoning,1246,"[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].","Is the triple ""ATROPINE related to poisoning"" supported by the sentence: ""[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].""?",False, +19468294,ATROPINE causes Pain,1247,"In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.","Is the triple ""ATROPINE causes Pain"" supported by the sentence: ""In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.""?",False, +18989245,ATROPINE causes digestive system disorder,1248,"With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.","Is the triple ""ATROPINE causes digestive system disorder"" supported by the sentence: ""With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.""?",False, +14576640,ATROPINE causes myopia,1249,"PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.","Is the triple ""ATROPINE causes myopia"" supported by the sentence: ""PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.""?",False, +10716177,ATROPINE causes Mydriasis,1250,"The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.","Is the triple ""ATROPINE causes Mydriasis"" supported by the sentence: ""The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.""?",False, +10361041,ATROPINE causes amblyopia,1251,"OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.","Is the triple ""ATROPINE causes amblyopia"" supported by the sentence: ""OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.""?",False, +9746341,ATROPINE causes poisoning,1252,"Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.","Is the triple ""ATROPINE causes poisoning"" supported by the sentence: ""Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.""?",False, +9301311,ATROPINE causes cardiac arrest,1253,"Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.","Is the triple ""ATROPINE causes cardiac arrest"" supported by the sentence: ""Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.""?",False, +8524259,ATROPINE causes Insulin resistance,1254,Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.,"Is the triple ""ATROPINE causes Insulin resistance"" supported by the sentence: ""Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.""?",False, +8480152,ATROPINE causes Bradycardia,1255,In 6-week-old rats atropine produced bradycardia instead of tachycardia.,"Is the triple ""ATROPINE causes Bradycardia"" supported by the sentence: ""In 6-week-old rats atropine produced bradycardia instead of tachycardia.""?",False, +26343406,ATROPINE affects hypoglycemia,1256,"3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.""?",False, +23118209,ATROPINE affects Mydriasis,1257,Both im and iv atropine had similar effects on weight loss rate and mydriasis.,"Is the triple ""ATROPINE affects Mydriasis"" supported by the sentence: ""Both im and iv atropine had similar effects on weight loss rate and mydriasis.""?",False, +19520979,ATROPINE affects hypoglycemia,1258,"The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.""?",False, +12406813,ATROPINE affects cardiac arrest,1259,Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.,"Is the triple ""ATROPINE affects cardiac arrest"" supported by the sentence: ""Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.""?",False, +11741867,ATROPINE affects Bradycardia,1260,"LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.""?",False, +10264479,ATROPINE affects Hemorrhage,1261,"Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.","Is the triple ""ATROPINE affects Hemorrhage"" supported by the sentence: ""Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.""?",False, +9293832,ATROPINE affects poisoning,1262,"Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.","Is the triple ""ATROPINE affects poisoning"" supported by the sentence: ""Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.""?",False, +9041302,ATROPINE affects Bradycardia,1263,"This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.""?",False, +7845760,ATROPINE affects Bradycardia,1264,"CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.""?",False, +7111083,ATROPINE affects myopia,1265,"These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.","Is the triple ""ATROPINE affects myopia"" supported by the sentence: ""These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.""?",False, +26141463,ATROPINE disrupts hypoglycemia,1266,The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.,"Is the triple ""ATROPINE disrupts hypoglycemia"" supported by the sentence: ""The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.""?",False, +23143978,ATROPINE disrupts poisoning,1267,"Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.","Is the triple ""ATROPINE disrupts poisoning"" supported by the sentence: ""Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.""?",False, +20133204,ATROPINE disrupts Pain,1268,Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?,"Is the triple ""ATROPINE disrupts Pain"" supported by the sentence: ""Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?""?",False, +18168420,ATROPINE disrupts Bradycardia,1269,"After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.","Is the triple ""ATROPINE disrupts Bradycardia"" supported by the sentence: ""After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.""?",False, +7111084,ATROPINE disrupts myopia,1270,"Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.","Is the triple ""ATROPINE disrupts myopia"" supported by the sentence: ""Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.""?",False, +9676858,ATROPINE prevents poisoning,1271,Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.,"Is the triple ""ATROPINE prevents poisoning"" supported by the sentence: ""Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.""?",False, +9198373,ATROPINE prevents myopia,1272,"One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.","Is the triple ""ATROPINE prevents myopia"" supported by the sentence: ""One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.""?",False, +8451883,ATROPINE prevents cardiac arrest,1273,Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.,"Is the triple ""ATROPINE prevents cardiac arrest"" supported by the sentence: ""Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.""?",False, +23699298,ATROPINE predisposes myopia,1274,"Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).","Is the triple ""ATROPINE predisposes myopia"" supported by the sentence: ""Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).""?",False, +14640163,ATROPINE predisposes poisoning,1275,"A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.","Is the triple ""ATROPINE predisposes poisoning"" supported by the sentence: ""A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.""?",False, +7953996,Tolcapone affects Parkinson disease,1276,"Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.","Is the triple ""Tolcapone affects Parkinson disease"" supported by the sentence: ""Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.""?",False, +15643297,Entacapone related to Parkinson disease,1277,OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.,"Is the triple ""Entacapone related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.""?",False, +10033650,Entacapone causes Parkinson disease,1278,"Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.","Is the triple ""Entacapone causes Parkinson disease"" supported by the sentence: ""Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.""?",False, +15952178,Entacapone affects Parkinson disease,1279,Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.,"Is the triple ""Entacapone affects Parkinson disease"" supported by the sentence: ""Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.""?",False, +20308336,Entacapone disrupts Parkinson disease,1280,"Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).","Is the triple ""Entacapone disrupts Parkinson disease"" supported by the sentence: ""Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).""?",False, +25394620,Veliparib affects neoplasm,1281,"[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).","Is the triple ""Veliparib affects neoplasm"" supported by the sentence: ""[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).""?",False, +21697473,Veliparib affects triple-negative breast carcinoma,1282,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Veliparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, +21882624,Talazoparib causes neoplasm,1283,"In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.","Is the triple ""Talazoparib causes neoplasm"" supported by the sentence: ""In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.""?",False, +22572154,Talazoparib affects neoplasm,1284,The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.,"Is the triple ""Talazoparib affects neoplasm"" supported by the sentence: ""The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.""?",False, +21697476,Talazoparib affects triple-negative breast carcinoma,1285,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Talazoparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, +22916819,Talazoparib prevents neoplasm,1286,Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.,"Is the triple ""Talazoparib prevents neoplasm"" supported by the sentence: ""Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.""?",False, +24451977,Olaparib related to triple-negative breast carcinoma,1287,"Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.","Is the triple ""Olaparib related to triple-negative breast carcinoma"" supported by the sentence: ""Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.""?",False, +25473017,Olaparib causes pancreatic ductal adenocarcinoma,1288,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes pancreatic ductal adenocarcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, +25473016,Olaparib causes non-small cell lung carcinoma,1289,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes non-small cell lung carcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, +22160122,Olaparib causes head and neck neoplasm,1290,"Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.","Is the triple ""Olaparib causes head and neck neoplasm"" supported by the sentence: ""Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.""?",False, +24770500,Olaparib affects castration-resistant prostate carcinoma,1291,Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.,"Is the triple ""Olaparib affects castration-resistant prostate carcinoma"" supported by the sentence: ""Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.""?",False, +24672020,Olaparib affects prostate cancer,1292,"Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.","Is the triple ""Olaparib affects prostate cancer"" supported by the sentence: ""Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.""?",False, +22977330,Olaparib affects neoplasm,1293,TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.,"Is the triple ""Olaparib affects neoplasm"" supported by the sentence: ""TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.""?",False, +21697474,Olaparib affects triple-negative breast carcinoma,1294,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Olaparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, +24201965,Olaparib prevents Neoplasm Metastasis,1295,The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.,"Is the triple ""Olaparib prevents Neoplasm Metastasis"" supported by the sentence: ""The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.""?",False, +27698235,Capsaicin related to arthritic joint disease,1296,"Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.","Is the triple ""Capsaicin related to arthritic joint disease"" supported by the sentence: ""Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.""?",False, +22276323,Capsaicin related to herpes zoster,1297,Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.,"Is the triple ""Capsaicin related to herpes zoster"" supported by the sentence: ""Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.""?",False, +13200623,Capsaicin related to migraine disorder,1298,Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.,"Is the triple ""Capsaicin related to migraine disorder"" supported by the sentence: ""Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.""?",False, +11537529,Capsaicin related to Cough,1299,"Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.","Is the triple ""Capsaicin related to Cough"" supported by the sentence: ""Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.""?",False, +10028696,Capsaicin related to diabetic neuropathy,1300,"CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.","Is the triple ""Capsaicin related to diabetic neuropathy"" supported by the sentence: ""CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.""?",False, +8608120,Capsaicin related to osteoarthritis,1301,The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.,"Is the triple ""Capsaicin related to osteoarthritis"" supported by the sentence: ""The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.""?",False, +8470968,Capsaicin related to postherpetic neuralgia,1302,"These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.","Is the triple ""Capsaicin related to postherpetic neuralgia"" supported by the sentence: ""These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.""?",False, +8246278,Capsaicin related to neuralgia,1303,3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.,"Is the triple ""Capsaicin related to neuralgia"" supported by the sentence: ""3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.""?",False, +7965643,Capsaicin related to Pruritus,1304,"As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).","Is the triple ""Capsaicin related to Pruritus"" supported by the sentence: ""As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).""?",False, +7239245,Capsaicin related to Pain,1305,Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.,"Is the triple ""Capsaicin related to Pain"" supported by the sentence: ""Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.""?",False, +26554289,Capsaicin causes stroke disorder,1306,MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.,"Is the triple ""Capsaicin causes stroke disorder"" supported by the sentence: ""MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.""?",False, +24505933,Capsaicin causes Muscle spasm,1307,"The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.","Is the triple ""Capsaicin causes Muscle spasm"" supported by the sentence: ""The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.""?",False, +18391785,Capsaicin causes neuralgia,1308,Can topical capsaicin induce a neuropathic pain?,"Is the triple ""Capsaicin causes neuralgia"" supported by the sentence: ""Can topical capsaicin induce a neuropathic pain?""?",False, +16420383,Capsaicin causes migraine disorder,1309,CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.,"Is the triple ""Capsaicin causes migraine disorder"" supported by the sentence: ""CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.""?",False, +11163813,Capsaicin causes arthritic joint disease,1310,Capsaicin-induced joint inflammation is not blocked by local anesthesia.,"Is the triple ""Capsaicin causes arthritic joint disease"" supported by the sentence: ""Capsaicin-induced joint inflammation is not blocked by local anesthesia.""?",False, +9650510,Capsaicin causes Myalgia,1311,Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.,"Is the triple ""Capsaicin causes Myalgia"" supported by the sentence: ""Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.""?",False, +8975038,Capsaicin causes Vomiting,1312,"E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).","Is the triple ""Capsaicin causes Vomiting"" supported by the sentence: ""E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).""?",False, +8261437,Capsaicin causes Cough,1313,The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.,"Is the triple ""Capsaicin causes Cough"" supported by the sentence: ""The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.""?",False, +7430731,Capsaicin causes Pruritus,1314,"Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.","Is the triple ""Capsaicin causes Pruritus"" supported by the sentence: ""Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.""?",False, +7414435,Capsaicin causes Pain,1315,Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.,"Is the triple ""Capsaicin causes Pain"" supported by the sentence: ""Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.""?",False, +27524804,Capsaicin affects arthritic joint disease,1316,Effects of capsaicin in temporomandibular joint arthritis in rats.,"Is the triple ""Capsaicin affects arthritic joint disease"" supported by the sentence: ""Effects of capsaicin in temporomandibular joint arthritis in rats.""?",False, +25438971,Capsaicin affects brain injury,1317,"Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.","Is the triple ""Capsaicin affects brain injury"" supported by the sentence: ""Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.""?",False, +19404541,Capsaicin affects neuroma,1318,"There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.","Is the triple ""Capsaicin affects neuroma"" supported by the sentence: ""There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.""?",False, +15791019,Capsaicin affects Pruritus,1319,"A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).""?",False, +10951234,Capsaicin affects stroke disorder,1320,"Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.","Is the triple ""Capsaicin affects stroke disorder"" supported by the sentence: ""Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.""?",False, +10764355,Capsaicin affects Pain,1321,"Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.""?",False, +10290167,Capsaicin affects Pruritus,1322,"As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.""?",False, +10171204,Capsaicin affects neuralgia,1323,"Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.","Is the triple ""Capsaicin affects neuralgia"" supported by the sentence: ""Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.""?",False, +8975035,Capsaicin affects Vomiting,1324,The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.,"Is the triple ""Capsaicin affects Vomiting"" supported by the sentence: ""The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.""?",False, +8515286,Capsaicin affects Pain,1325,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, +8515285,Capsaicin affects postherpetic neuralgia,1326,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects postherpetic neuralgia"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, +8441743,Capsaicin affects Cough,1327,Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.""?",False, +7281158,Capsaicin affects Cough,1328,Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.""?",False, +18283970,Capsaicin disrupts Pain,1329,"Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.","Is the triple ""Capsaicin disrupts Pain"" supported by the sentence: ""Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.""?",False, +17652809,Capsaicin disrupts arthritic joint disease,1330,Capsaicin suppresses substance P-induced joint inflammation in the rat.,"Is the triple ""Capsaicin disrupts arthritic joint disease"" supported by the sentence: ""Capsaicin suppresses substance P-induced joint inflammation in the rat.""?",False, +14643733,Capsaicin disrupts breast neoplasm,1331,"Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.","Is the triple ""Capsaicin disrupts breast neoplasm"" supported by the sentence: ""Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.""?",False, +9869751,Capsaicin disrupts Cough,1332,"To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.","Is the triple ""Capsaicin disrupts Cough"" supported by the sentence: ""To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.""?",False, +8160008,Capsaicin disrupts Pruritus,1333,RESULTS: Capsaicin suppressed completely itch in all patients.,"Is the triple ""Capsaicin disrupts Pruritus"" supported by the sentence: ""RESULTS: Capsaicin suppressed completely itch in all patients.""?",False, +25438980,Capsaicin prevents brain injury,1334,Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.,"Is the triple ""Capsaicin prevents brain injury"" supported by the sentence: ""Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.""?",False, +20404597,Capsaicin prevents postherpetic neuralgia,1335,The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.,"Is the triple ""Capsaicin prevents postherpetic neuralgia"" supported by the sentence: ""The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.""?",False, +17168513,Capsaicin prevents migraine disorder,1336,"Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.","Is the triple ""Capsaicin prevents migraine disorder"" supported by the sentence: ""Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.""?",False, +16978917,Capsaicin prevents neuralgia,1337,Capsaicin treatment is one method to reduce neuropathic pain.,"Is the triple ""Capsaicin prevents neuralgia"" supported by the sentence: ""Capsaicin treatment is one method to reduce neuropathic pain.""?",False, +15822967,Capsaicin prevents stroke disorder,1338,We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).,"Is the triple ""Capsaicin prevents stroke disorder"" supported by the sentence: ""We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).""?",False, +10290168,Capsaicin prevents Pruritus,1339,"In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.","Is the triple ""Capsaicin prevents Pruritus"" supported by the sentence: ""In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.""?",False, +8608117,Capsaicin prevents osteoarthritis,1340,The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.,"Is the triple ""Capsaicin prevents osteoarthritis"" supported by the sentence: ""The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.""?",False, +8246280,Capsaicin prevents Pain,1341,"RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.","Is the triple ""Capsaicin prevents Pain"" supported by the sentence: ""RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.""?",False, +14706687,Capsaicin predisposes Pain,1342,These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.,"Is the triple ""Capsaicin predisposes Pain"" supported by the sentence: ""These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.""?",False, +24021484,Nusinersen causes spinal muscular atrophy,1343,"Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.","Is the triple ""Nusinersen causes spinal muscular atrophy"" supported by the sentence: ""Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.""?",False, +22907909,Nusinersen affects spinal muscular atrophy,1344,More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.,"Is the triple ""Nusinersen affects spinal muscular atrophy"" supported by the sentence: ""More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.""?",False, +27681284,Hyaluronic acid sodium salt related to alcoholic hepatitis,1345,"These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.","Is the triple ""Hyaluronic acid sodium salt related to alcoholic hepatitis"" supported by the sentence: ""These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.""?",False, +26794689,Hyaluronic acid sodium salt related to carpal tunnel syndrome,1346,"In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.","Is the triple ""Hyaluronic acid sodium salt related to carpal tunnel syndrome"" supported by the sentence: ""In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.""?",False, +20903427,Hyaluronic acid sodium salt related to Skin ulcer,1347,Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.,"Is the triple ""Hyaluronic acid sodium salt related to Skin ulcer"" supported by the sentence: ""Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.""?",False, +18915649,Hyaluronic acid sodium salt related to Hyaluronidase,1348,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, +18915649,Hyaluronic acid sodium salt related to Hyaluronidase,1349,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, +15362486,Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder,1350,OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.,"Is the triple ""Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder"" supported by the sentence: ""OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.""?",False, +14268478,Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease,1351,Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.,"Is the triple ""Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease"" supported by the sentence: ""Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.""?",False, +9147590,Hyaluronic acid sodium salt related to dry eye syndrome,1352,Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.,"Is the triple ""Hyaluronic acid sodium salt related to dry eye syndrome"" supported by the sentence: ""Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.""?",False, +7458117,Hyaluronic acid sodium salt related to osteoarthritis,1353,OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.,"Is the triple ""Hyaluronic acid sodium salt related to osteoarthritis"" supported by the sentence: ""OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.""?",False, +17074499,Hyaluronic acid sodium salt related to Hyaluronidase,1354,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, +17074499,Hyaluronic acid sodium salt related to Hyaluronidase,1355,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, +12401778,Hyaluronic acid sodium salt has part Hyaluronidase,1356,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, +12401778,Hyaluronic acid sodium salt has part Hyaluronidase,1357,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, +11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,1358,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, +11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,1359,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, +7287149,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,1360,The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.""?",False, +7699622,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,1361,Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.""?",False, +12146167,Hyaluronic acid sodium salt causes osteoarthritis,1362,We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).,"Is the triple ""Hyaluronic acid sodium salt causes osteoarthritis"" supported by the sentence: ""We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).""?",False, +8938037,Hyaluronic acid sodium salt affects osteoarthritis,1363,"RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.","Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.""?",False, +8541022,Hyaluronic acid sodium salt affects osteoarthritis,1364,The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.,"Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.""?",False, +7683831,Hyaluronic acid sodium salt affects Hyaluronidase,1365,Such small HA fragments are generated from the degradation of HA by hyaluronidase.,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""Such small HA fragments are generated from the degradation of HA by hyaluronidase.""?",False, +7895314,Hyaluronic acid sodium salt affects Hyaluronidase,1366,RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).""?",False, +18839068,Hyaluronic acid sodium salt produces Hyaluronidase,1367,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, +18839068,Hyaluronic acid sodium salt produces Hyaluronidase,1368,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, +9813251,Hyaluronic acid sodium salt produces Hyaluronidase,1369,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, +9813251,Hyaluronic acid sodium salt produces Hyaluronidase,1370,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, +17165364,Hyaluronic acid sodium salt has input Hyaluronidase,1371,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, +17165364,Hyaluronic acid sodium salt has input Hyaluronidase,1372,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, +23839601,Hyaluronic acid sodium salt disrupts dry eye syndrome,1373,Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.,"Is the triple ""Hyaluronic acid sodium salt disrupts dry eye syndrome"" supported by the sentence: ""Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.""?",False, +22764727,Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder,1374,"Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.","Is the triple ""Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder"" supported by the sentence: ""Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.""?",False, +7155073,Hyaluronic acid sodium salt disrupts osteoarthritis,1375,"Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.","Is the triple ""Hyaluronic acid sodium salt disrupts osteoarthritis"" supported by the sentence: ""Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.""?",False, +18262848,Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease,1376,Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.,"Is the triple ""Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.""?",False, +11511344,Hyaluronic acid sodium salt prevents osteoarthritis,1377,The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.,"Is the triple ""Hyaluronic acid sodium salt prevents osteoarthritis"" supported by the sentence: ""The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.""?",False, +21264578,Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder,1378,"CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.","Is the triple ""Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder"" supported by the sentence: ""CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.""?",False, +11605823,Hyaluronic acid sodium salt predisposes osteoarthritis,1379,CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.,"Is the triple ""Hyaluronic acid sodium salt predisposes osteoarthritis"" supported by the sentence: ""CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.""?",False, +24659748,Zoledronic acid related to osteoporosis,1380,"Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.","Is the triple ""Zoledronic acid related to osteoporosis"" supported by the sentence: ""Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.""?",False, +18902207,Zoledronic acid causes Marchiafava-Bignami disease,1381,Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.,"Is the triple ""Zoledronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.""?",False, +18856931,Zoledronic acid causes hepatocellular carcinoma,1382,"This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.","Is the triple ""Zoledronic acid causes hepatocellular carcinoma"" supported by the sentence: ""This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.""?",False, +13083414,Zoledronic acid causes bone fracture,1383,"The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.","Is the triple ""Zoledronic acid causes bone fracture"" supported by the sentence: ""The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.""?",False, +21044659,Zoledronic acid affects Marchiafava-Bignami disease,1384,Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.,"Is the triple ""Zoledronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.""?",False, +19059032,Zoledronic acid affects bone osteosarcoma,1385,"BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.","Is the triple ""Zoledronic acid affects bone osteosarcoma"" supported by the sentence: ""BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.""?",False, +13892047,Zoledronic acid affects bone fracture,1386,Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.,"Is the triple ""Zoledronic acid affects bone fracture"" supported by the sentence: ""Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.""?",False, +13448998,Zoledronic acid affects osteonecrosis,1387,"Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.","Is the triple ""Zoledronic acid affects osteonecrosis"" supported by the sentence: ""Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.""?",False, +9617769,Zoledronic acid affects osteoporosis,1388,Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.,"Is the triple ""Zoledronic acid affects osteoporosis"" supported by the sentence: ""Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.""?",False, +24472422,Zoledronic acid disrupts sarcoma,1389,Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.,"Is the triple ""Zoledronic acid disrupts sarcoma"" supported by the sentence: ""Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.""?",False, +20879055,Zoledronic acid disrupts Neoplasm Metastasis,1390,"Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.","Is the triple ""Zoledronic acid disrupts Neoplasm Metastasis"" supported by the sentence: ""Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.""?",False, +20879053,Zoledronic acid disrupts Pain,1391,Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.,"Is the triple ""Zoledronic acid disrupts Pain"" supported by the sentence: ""Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.""?",False, +13311906,Zoledronic acid disrupts hepatocellular carcinoma,1392,"Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.","Is the triple ""Zoledronic acid disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.""?",False, +9617771,Zoledronic acid disrupts bone fracture,1393,"If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.","Is the triple ""Zoledronic acid disrupts bone fracture"" supported by the sentence: ""If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.""?",False, +22662537,Zoledronic acid prevents osteoporosis,1394,"As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.","Is the triple ""Zoledronic acid prevents osteoporosis"" supported by the sentence: ""As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.""?",False, +20148397,Zoledronic acid prevents osteonecrosis,1395,Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.,"Is the triple ""Zoledronic acid prevents osteonecrosis"" supported by the sentence: ""Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.""?",False, +13621414,Zoledronic acid prevents bone fracture,1396,"5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.","Is the triple ""Zoledronic acid prevents bone fracture"" supported by the sentence: ""5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.""?",False, +12127006,Zoledronic acid prevents Marchiafava-Bignami disease,1397,CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.,"Is the triple ""Zoledronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.""?",False, +20851623,Zoledronic acid predisposes bone fracture,1398,"A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.","Is the triple ""Zoledronic acid predisposes bone fracture"" supported by the sentence: ""A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.""?",False, +15272127,Zoledronic acid predisposes osteonecrosis,1399,"Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.","Is the triple ""Zoledronic acid predisposes osteonecrosis"" supported by the sentence: ""Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.""?",False, +14006582,Risedronic acid prevents osteoporosis,1400,"A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.","Is the triple ""Risedronic acid prevents osteoporosis"" supported by the sentence: ""A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.""?",False, +17290459,IBANDRONIC ACID affects osteonecrosis,1401,"Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.","Is the triple ""IBANDRONIC ACID affects osteonecrosis"" supported by the sentence: ""Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.""?",False, +9797983,IBANDRONIC ACID affects Neoplasm Metastasis,1402,Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.,"Is the triple ""IBANDRONIC ACID affects Neoplasm Metastasis"" supported by the sentence: ""Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.""?",False, +15290649,IBANDRONIC ACID prevents bone disorder,1403,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""IBANDRONIC ACID prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, +13697992,IBANDRONIC ACID prevents Pain,1404,"Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.","Is the triple ""IBANDRONIC ACID prevents Pain"" supported by the sentence: ""Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.""?",False, +10307139,IBANDRONIC ACID prevents postmenopausal osteoporosis,1405,"OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.","Is the triple ""IBANDRONIC ACID prevents postmenopausal osteoporosis"" supported by the sentence: ""OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.""?",False, +10028971,IBANDRONIC ACID prevents osteoporosis,1406,These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.,"Is the triple ""IBANDRONIC ACID prevents osteoporosis"" supported by the sentence: ""These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.""?",False, +18363632,IBANDRONIC ACID predisposes Abdominal pain,1407,"The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.","Is the triple ""IBANDRONIC ACID predisposes Abdominal pain"" supported by the sentence: ""The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.""?",False, +9434475,IBANDRONIC ACID predisposes osteoporosis,1408,The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.,"Is the triple ""IBANDRONIC ACID predisposes osteoporosis"" supported by the sentence: ""The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.""?",False, +17514758,Alendronic acid related to osteoarthritis,1409,OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.,"Is the triple ""Alendronic acid related to osteoarthritis"" supported by the sentence: ""OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.""?",False, +14283477,Alendronic acid related to osteoporosis,1410,"To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.","Is the triple ""Alendronic acid related to osteoporosis"" supported by the sentence: ""To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.""?",False, +11575454,Alendronic acid related to postmenopausal osteoporosis,1411,Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.,"Is the triple ""Alendronic acid related to postmenopausal osteoporosis"" supported by the sentence: ""Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.""?",False, +14254304,Alendronic acid causes asthma,1412,Alendronate-induced asthma.,"Is the triple ""Alendronic acid causes asthma"" supported by the sentence: ""Alendronate-induced asthma.""?",False, +14049757,Alendronic acid causes osteoporosis,1413,The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.,"Is the triple ""Alendronic acid causes osteoporosis"" supported by the sentence: ""The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.""?",False, +11710947,Alendronic acid causes Marchiafava-Bignami disease,1414,Alendronate as an effective countermeasure to disuse induced bone loss.,"Is the triple ""Alendronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate as an effective countermeasure to disuse induced bone loss.""?",False, +25124892,Alendronic acid affects Marchiafava-Bignami disease,1415,"EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.","Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.""?",False, +24296937,Alendronic acid affects bone disorder,1416,The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.,"Is the triple ""Alendronic acid affects bone disorder"" supported by the sentence: ""The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.""?",False, +17701514,Alendronic acid affects osteoarthritis,1417,This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.,"Is the triple ""Alendronic acid affects osteoarthritis"" supported by the sentence: ""This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.""?",False, +14769549,Alendronic acid affects postmenopausal osteoporosis,1418,The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.,"Is the triple ""Alendronic acid affects postmenopausal osteoporosis"" supported by the sentence: ""The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.""?",False, +12316243,Alendronic acid affects osteoporosis,1419,"Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.","Is the triple ""Alendronic acid affects osteoporosis"" supported by the sentence: ""Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.""?",False, +12136907,Alendronic acid affects periodontitis,1420,We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.,"Is the triple ""Alendronic acid affects periodontitis"" supported by the sentence: ""We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.""?",False, +8809813,Alendronic acid affects Marchiafava-Bignami disease,1421,We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.,"Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.""?",False, +22627610,Alendronic acid disrupts aortic valve stenosis,1422,Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.,"Is the triple ""Alendronic acid disrupts aortic valve stenosis"" supported by the sentence: ""Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.""?",False, +17047070,Alendronic acid disrupts prostate cancer,1423,"For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).","Is the triple ""Alendronic acid disrupts prostate cancer"" supported by the sentence: ""For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).""?",False, +9109277,Alendronic acid disrupts Marchiafava-Bignami disease,1424,"Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.","Is the triple ""Alendronic acid disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.""?",False, +8466156,Alendronic acid disrupts postmenopausal osteoporosis,1425,(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.,"Is the triple ""Alendronic acid disrupts postmenopausal osteoporosis"" supported by the sentence: ""(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.""?",False, +24628288,Alendronic acid prevents osteoarthritis,1426,"Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.","Is the triple ""Alendronic acid prevents osteoarthritis"" supported by the sentence: ""Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.""?",False, +15290647,Alendronic acid prevents bone disorder,1427,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""Alendronic acid prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, +7495571,Alendronic acid prevents osteoporosis,1428,"Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.","Is the triple ""Alendronic acid prevents osteoporosis"" supported by the sentence: ""Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.""?",False, +7314446,Alendronic acid prevents Marchiafava-Bignami disease,1429,Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.,"Is the triple ""Alendronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.""?",False, +7150371,Alendronic acid prevents postmenopausal osteoporosis,1430,Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).,"Is the triple ""Alendronic acid prevents postmenopausal osteoporosis"" supported by the sentence: ""Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).""?",False, +25381093,Alendronic acid predisposes osteoporosis,1431,"In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.","Is the triple ""Alendronic acid predisposes osteoporosis"" supported by the sentence: ""In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.""?",False, +22975353,Alendronic acid predisposes Marchiafava-Bignami disease,1432,We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.,"Is the triple ""Alendronic acid predisposes Marchiafava-Bignami disease"" supported by the sentence: ""We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.""?",False, +12652815,Pamidronic acid related to osteoporosis,1433,The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.,"Is the triple ""Pamidronic acid related to osteoporosis"" supported by the sentence: ""The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.""?",False, +7541169,Pamidronic acid related to plasma cell myeloma,1434,Effect of calcitriol and pamidronate in multiple myeloma.,"Is the triple ""Pamidronic acid related to plasma cell myeloma"" supported by the sentence: ""Effect of calcitriol and pamidronate in multiple myeloma.""?",False, +12040766,Pamidronic acid affects plasma cell myeloma,1435,"MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.","Is the triple ""Pamidronic acid affects plasma cell myeloma"" supported by the sentence: ""MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.""?",False, +10860757,Pamidronic acid affects osteoporosis,1436,The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.,"Is the triple ""Pamidronic acid affects osteoporosis"" supported by the sentence: ""The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.""?",False, +9170219,Pamidronic acid prevents osteoporosis,1437,Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.,"Is the triple ""Pamidronic acid prevents osteoporosis"" supported by the sentence: ""Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.""?",False, +9315699,Octyl methoxycinnamate prevents sunburn,1438,"In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.","Is the triple ""Octyl methoxycinnamate prevents sunburn"" supported by the sentence: ""In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.""?",False, +10529058,4-Aminobenzoic acid coexists with Procaine,1439,[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].,"Is the triple ""4-Aminobenzoic acid coexists with Procaine"" supported by the sentence: ""[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].""?",False, +25771688,Nitrazepam causes epilepsy,1440,The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.,"Is the triple ""Nitrazepam causes epilepsy"" supported by the sentence: ""The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.""?",False, +19206956,Nitrazepam affects depressive disorder,1441,The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.,"Is the triple ""Nitrazepam affects depressive disorder"" supported by the sentence: ""The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.""?",False, +25737609,Nitrazepam disrupts epilepsy,1442,"Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.","Is the triple ""Nitrazepam disrupts epilepsy"" supported by the sentence: ""Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.""?",False, +7322742,Nitrazepam prevents epilepsy,1443,NZP was discontinued if there was < 50% seizure reduction or significant side effects.,"Is the triple ""Nitrazepam prevents epilepsy"" supported by the sentence: ""NZP was discontinued if there was < 50% seizure reduction or significant side effects.""?",False, +25779340,Flurazepam causes depressive disorder,1444,"Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.","Is the triple ""Flurazepam causes depressive disorder"" supported by the sentence: ""Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.""?",False, +19092155,Triazolam causes depressive disorder,1445,"In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.","Is the triple ""Triazolam causes depressive disorder"" supported by the sentence: ""In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.""?",False, +16852864,Triazolam causes insomnia,1446,"This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.","Is the triple ""Triazolam causes insomnia"" supported by the sentence: ""This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.""?",False, +27224077,Triazolam affects insomnia,1447,OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).,"Is the triple ""Triazolam affects insomnia"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).""?",False, +15159227,Triazolam disrupts anxiety,1448,Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.,"Is the triple ""Triazolam disrupts anxiety"" supported by the sentence: ""Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.""?",False, +24702695,Midazolam related to delirium,1449,"The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.","Is the triple ""Midazolam related to delirium"" supported by the sentence: ""The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.""?",False, +16327495,Midazolam related to obesity disorder,1450,The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.,"Is the triple ""Midazolam related to obesity disorder"" supported by the sentence: ""The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.""?",False, +17503618,Midazolam causes Nausea,1451,Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.,"Is the triple ""Midazolam causes Nausea"" supported by the sentence: ""Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.""?",False, +13087342,Midazolam causes status epilepticus,1452,PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.,"Is the triple ""Midazolam causes status epilepticus"" supported by the sentence: ""PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.""?",False, +12880145,Midazolam causes delirium,1453,"Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.","Is the triple ""Midazolam causes delirium"" supported by the sentence: ""Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.""?",False, +12134398,Midazolam causes brain injury,1454,"Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.","Is the triple ""Midazolam causes brain injury"" supported by the sentence: ""Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.""?",False, +11162624,Midazolam causes Pain,1455,Sedation with midazolam leads to reduced pain after dental surgery.,"Is the triple ""Midazolam causes Pain"" supported by the sentence: ""Sedation with midazolam leads to reduced pain after dental surgery.""?",False, +10221339,Midazolam causes injury,1456,"CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.","Is the triple ""Midazolam causes injury"" supported by the sentence: ""CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.""?",False, +10197463,Midazolam causes epilepsy,1457,Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.,"Is the triple ""Midazolam causes epilepsy"" supported by the sentence: ""Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.""?",False, +7739374,Midazolam causes hypotensive disorder,1458,"For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.","Is the triple ""Midazolam causes hypotensive disorder"" supported by the sentence: ""For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.""?",False, +7211473,Midazolam causes depressive disorder,1459,We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.,"Is the triple ""Midazolam causes depressive disorder"" supported by the sentence: ""We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.""?",False, +7104276,Midazolam causes dissociative amnesia,1460,"In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.","Is the triple ""Midazolam causes dissociative amnesia"" supported by the sentence: ""In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.""?",False, +27271852,Midazolam affects Pruritus,1461,"In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.","Is the triple ""Midazolam affects Pruritus"" supported by the sentence: ""In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.""?",False, +26121850,Midazolam affects Pain,1462,"Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.","Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.""?",False, +25522494,Midazolam affects anxiety,1463,"Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.""?",False, +22514965,Midazolam affects anxiety,1464,"A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.""?",False, +22203290,Midazolam affects post-traumatic stress disorder,1465,The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.,"Is the triple ""Midazolam affects post-traumatic stress disorder"" supported by the sentence: ""The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.""?",False, +21411467,Midazolam affects Suicidal ideation,1466,"Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).","Is the triple ""Midazolam affects Suicidal ideation"" supported by the sentence: ""Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).""?",False, +20820424,Midazolam affects injury,1467,"Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.","Is the triple ""Midazolam affects injury"" supported by the sentence: ""Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.""?",False, +20230773,Midazolam affects hypotensive disorder,1468,Sudden hypotension associated with midazolam and sufentanil.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""Sudden hypotension associated with midazolam and sufentanil.""?",False, +19683992,Midazolam affects injury,1469,Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.,"Is the triple ""Midazolam affects injury"" supported by the sentence: ""Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.""?",False, +18986257,Midazolam affects neoplasm,1470,Studies have also shown that midazolam has an anticancer effect on various tumors.,"Is the triple ""Midazolam affects neoplasm"" supported by the sentence: ""Studies have also shown that midazolam has an anticancer effect on various tumors.""?",False, +18893940,Midazolam affects hypertensive disorder,1471,"Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.","Is the triple ""Midazolam affects hypertensive disorder"" supported by the sentence: ""Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.""?",False, +18670184,Midazolam affects hypotensive disorder,1472,"According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.","Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.""?",False, +18644607,Midazolam affects neuralgia,1473,Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.,"Is the triple ""Midazolam affects neuralgia"" supported by the sentence: ""Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.""?",False, +18331473,Midazolam affects status epilepticus,1474,"The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.","Is the triple ""Midazolam affects status epilepticus"" supported by the sentence: ""The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.""?",False, +17655582,Midazolam affects Cough,1475,Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.,"Is the triple ""Midazolam affects Cough"" supported by the sentence: ""Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.""?",False, +12605496,Midazolam affects dissociative amnesia,1476,Midazolam tends to have more favorable effects on amnesia.,"Is the triple ""Midazolam affects dissociative amnesia"" supported by the sentence: ""Midazolam tends to have more favorable effects on amnesia.""?",False, +12154940,Midazolam affects Nausea,1477,"We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.","Is the triple ""Midazolam affects Nausea"" supported by the sentence: ""We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.""?",False, +11981571,Midazolam affects delirium,1478,The development of delirium was associated with the medication midazolam taken perioperatively.,"Is the triple ""Midazolam affects delirium"" supported by the sentence: ""The development of delirium was associated with the medication midazolam taken perioperatively.""?",False, +8867560,Midazolam affects Pain,1479,Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.,"Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.""?",False, +8871799,Midazolam affects hypotensive disorder,1480,The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.""?",False, +8701804,Midazolam affects epilepsy,1481,Nasal midazolam effects on childhood acute seizures.,"Is the triple ""Midazolam affects epilepsy"" supported by the sentence: ""Nasal midazolam effects on childhood acute seizures.""?",False, +8569605,Midazolam affects brain injury,1482,"Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.","Is the triple ""Midazolam affects brain injury"" supported by the sentence: ""Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.""?",False, +7116661,Midazolam affects Postoperative Nausea and Vomiting,1483,The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.,"Is the triple ""Midazolam affects Postoperative Nausea and Vomiting"" supported by the sentence: ""The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.""?",False, +20025306,Midazolam disrupts Pruritus,1484,"Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.","Is the triple ""Midazolam disrupts Pruritus"" supported by the sentence: ""Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.""?",False, +18424847,Midazolam disrupts status epilepticus,1485,"Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.","Is the triple ""Midazolam disrupts status epilepticus"" supported by the sentence: ""Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.""?",False, +16150704,Midazolam disrupts Cough,1486,CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.,"Is the triple ""Midazolam disrupts Cough"" supported by the sentence: ""CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.""?",False, +14733481,Midazolam disrupts neuralgia,1487,Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.,"Is the triple ""Midazolam disrupts neuralgia"" supported by the sentence: ""Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.""?",False, +13861580,Midazolam disrupts Pain,1488,"CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.","Is the triple ""Midazolam disrupts Pain"" supported by the sentence: ""CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.""?",False, +9443524,Midazolam disrupts epilepsy,1489,"PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.","Is the triple ""Midazolam disrupts epilepsy"" supported by the sentence: ""PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.""?",False, +7819099,Midazolam disrupts anxiety,1490,CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.,"Is the triple ""Midazolam disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.""?",False, +21663738,Midazolam prevents anxiety,1491,This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.,"Is the triple ""Midazolam prevents anxiety"" supported by the sentence: ""This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.""?",False, +20820423,Midazolam prevents injury,1492,Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.,"Is the triple ""Midazolam prevents injury"" supported by the sentence: ""Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.""?",False, +17322994,Midazolam prevents Aggressive behavior,1493,"Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.","Is the triple ""Midazolam prevents Aggressive behavior"" supported by the sentence: ""Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.""?",False, +16397367,Midazolam prevents status epilepticus,1494,"Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.","Is the triple ""Midazolam prevents status epilepticus"" supported by the sentence: ""Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.""?",False, +13467675,Midazolam prevents Nausea,1495,Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.,"Is the triple ""Midazolam prevents Nausea"" supported by the sentence: ""Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.""?",False, +11373548,Midazolam prevents Cough,1496,"CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.","Is the triple ""Midazolam prevents Cough"" supported by the sentence: ""CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.""?",False, +11041799,Midazolam prevents bone fracture,1497,"Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.","Is the triple ""Midazolam prevents bone fracture"" supported by the sentence: ""Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.""?",False, +9493413,Midazolam prevents epilepsy,1498,"Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.","Is the triple ""Midazolam prevents epilepsy"" supported by the sentence: ""Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.""?",False, +8653279,Midazolam prevents Sepsis,1499,"Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.","Is the triple ""Midazolam prevents Sepsis"" supported by the sentence: ""Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.""?",False, +8569600,Midazolam prevents brain injury,1500,"Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.","Is the triple ""Midazolam prevents brain injury"" supported by the sentence: ""Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.""?",False, +8151023,Midazolam prevents Pain,1501,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Midazolam prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, +7116663,Midazolam prevents Postoperative Nausea and Vomiting,1502,We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.,"Is the triple ""Midazolam prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.""?",False, +16657523,Midazolam exacerbates Sepsis,1503,"METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.","Is the triple ""Midazolam exacerbates Sepsis"" supported by the sentence: ""METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.""?",False, +19191198,Midazolam predisposes dissociative amnesia,1504,This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.,"Is the triple ""Midazolam predisposes dissociative amnesia"" supported by the sentence: ""This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.""?",False, +18422952,Midazolam predisposes status epilepticus,1505,"Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.","Is the triple ""Midazolam predisposes status epilepticus"" supported by the sentence: ""Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.""?",False, +11981572,Midazolam predisposes delirium,1506,The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.,"Is the triple ""Midazolam predisposes delirium"" supported by the sentence: ""The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.""?",False, +22402246,Brotizolam disrupts anxiety,1507,"Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.","Is the triple ""Brotizolam disrupts anxiety"" supported by the sentence: ""Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.""?",False, +12312025,Ganirelix related to polycystic ovary syndrome,1508,LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.,"Is the triple ""Ganirelix related to polycystic ovary syndrome"" supported by the sentence: ""LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.""?",False, +14831488,Cetrorelix disrupts benign prostatic hyperplasia,1509,Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.,"Is the triple ""Cetrorelix disrupts benign prostatic hyperplasia"" supported by the sentence: ""Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.""?",False, +18703871,Cetrorelix prevents endometriosis,1510,"CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.","Is the triple ""Cetrorelix prevents endometriosis"" supported by the sentence: ""CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.""?",False, +18874469,Methoxsalen related to Deoxyribonucleic acid,1511,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, +18874469,Methoxsalen related to Deoxyribonucleic acid,1512,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, +12069194,Methoxsalen related to mycosis fungoides,1513,Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.,"Is the triple ""Methoxsalen related to mycosis fungoides"" supported by the sentence: ""Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.""?",False, +8610329,Methoxsalen related to psoriasis,1514,"Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.","Is the triple ""Methoxsalen related to psoriasis"" supported by the sentence: ""Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.""?",False, +26218137,Methoxsalen related to Deoxyribonucleic acid,1515,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, +26218137,Methoxsalen related to Deoxyribonucleic acid,1516,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, +7172075,Methoxsalen coexists with Deoxyribonucleic acid,1517,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, +7172075,Methoxsalen coexists with Deoxyribonucleic acid,1518,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, +26761340,Methoxsalen coexists with Deoxyribonucleic acid,1519,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, +26761340,Methoxsalen coexists with Deoxyribonucleic acid,1520,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, +7782040,Methoxsalen physically interacts with Deoxyribonucleic acid,1521,"New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.","Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.""?",False, +12022213,Methoxsalen physically interacts with Deoxyribonucleic acid,1522,MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.,"Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.""?",False, +9512596,Methoxsalen affects Deoxyribonucleic acid,1523,"Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.""?",False, +19709381,Methoxsalen affects Deoxyribonucleic acid,1524,"Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.""?",False, +8674128,Trioxsalen coexists with Deoxyribonucleic acid,1525,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, +8674128,Trioxsalen coexists with Deoxyribonucleic acid,1526,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, +8674127,Trioxsalen physically interacts with Deoxyribonucleic acid,1527,"In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.","Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.""?",False, +25732039,Trioxsalen physically interacts with Deoxyribonucleic acid,1528,The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.,"Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.""?",False, +16826513,Trioxsalen affects Deoxyribonucleic acid,1529,"Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.","Is the triple ""Trioxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.""?",False, +9717834,Bisoprolol related to hypertensive disorder,1530,"Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.","Is the triple ""Bisoprolol related to hypertensive disorder"" supported by the sentence: ""Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.""?",False, +17484309,Bisoprolol affects Hemorrhage,1531,CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.,"Is the triple ""Bisoprolol affects Hemorrhage"" supported by the sentence: ""CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.""?",False, +14633716,Bisoprolol affects hypertensive disorder,1532,CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.,"Is the triple ""Bisoprolol affects hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.""?",False, +13150765,Bisoprolol affects pulmonary arterial hypertension,1533,"MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.","Is the triple ""Bisoprolol affects pulmonary arterial hypertension"" supported by the sentence: ""MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.""?",False, +24626572,Bisoprolol disrupts Hemorrhage,1534,No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.,"Is the triple ""Bisoprolol disrupts Hemorrhage"" supported by the sentence: ""No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.""?",False, +23315135,Bisoprolol prevents Hemorrhage,1535,"Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).","Is the triple ""Bisoprolol prevents Hemorrhage"" supported by the sentence: ""Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).""?",False, +26817035,Esmolol related to atrial fibrillation,1536,"In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.","Is the triple ""Esmolol related to atrial fibrillation"" supported by the sentence: ""In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.""?",False, +13689489,Esmolol causes atrial fibrillation,1537,Esmolol or atropine markedly increased the threshold for AF induction.,"Is the triple ""Esmolol causes atrial fibrillation"" supported by the sentence: ""Esmolol or atropine markedly increased the threshold for AF induction.""?",False, +20072391,Esmolol affects toxic shock syndrome,1538,The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.,"Is the triple ""Esmolol affects toxic shock syndrome"" supported by the sentence: ""The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.""?",False, +19519833,Esmolol affects Pain,1539,"Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.","Is the triple ""Esmolol affects Pain"" supported by the sentence: ""Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.""?",False, +16877299,Esmolol prevents Pain,1540,Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.,"Is the triple ""Esmolol prevents Pain"" supported by the sentence: ""Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.""?",False, +10180097,Esmolol prevents ischemia reperfusion injury,1541,"Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.","Is the triple ""Esmolol prevents ischemia reperfusion injury"" supported by the sentence: ""Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.""?",False, +9581320,Esmolol prevents atrial fibrillation,1542,We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.,"Is the triple ""Esmolol prevents atrial fibrillation"" supported by the sentence: ""We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.""?",False, +18235527,Oxygen related to pulmonary fibrosis,1543,"However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.","Is the triple ""Oxygen related to pulmonary fibrosis"" supported by the sentence: ""However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.""?",False, +18193743,Oxygen related to neoplasm,1544,Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.,"Is the triple ""Oxygen related to neoplasm"" supported by the sentence: ""Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.""?",False, +17303485,Oxygen related to Hypoxemia,1545,"CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.","Is the triple ""Oxygen related to Hypoxemia"" supported by the sentence: ""CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.""?",False, +14116536,Oxygen related to Shock,1546,The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.,"Is the triple ""Oxygen related to Shock"" supported by the sentence: ""The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.""?",False, +13587155,Oxygen related to injury,1547,These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.,"Is the triple ""Oxygen related to injury"" supported by the sentence: ""These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.""?",False, +8813011,Oxygen related to ischemia reperfusion injury,1548,Cardiac toxicity of singlet oxygen: implication in reperfusion injury.,"Is the triple ""Oxygen related to ischemia reperfusion injury"" supported by the sentence: ""Cardiac toxicity of singlet oxygen: implication in reperfusion injury.""?",False, +21893162,Oxygen causes neoplasm,1549,"Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.","Is the triple ""Oxygen causes neoplasm"" supported by the sentence: ""Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.""?",False, +19992109,Oxygen causes ischemia reperfusion injury,1550,The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.,"Is the triple ""Oxygen causes ischemia reperfusion injury"" supported by the sentence: ""The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.""?",False, +8243272,Oxygen causes vascular disorder,1551,"Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.","Is the triple ""Oxygen causes vascular disorder"" supported by the sentence: ""Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.""?",False, +8114891,Oxygen causes injury,1552,New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.,"Is the triple ""Oxygen causes injury"" supported by the sentence: ""New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.""?",False, +7992845,Oxygen causes Hypoxemia,1553,"At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.","Is the triple ""Oxygen causes Hypoxemia"" supported by the sentence: ""At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.""?",False, +7752235,Oxygen causes stroke disorder,1554,We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.,"Is the triple ""Oxygen causes stroke disorder"" supported by the sentence: ""We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.""?",False, +23272853,Oxygen affects neoplasm,1555,"The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.""?",False, +22206348,Oxygen affects neoplasm,1556,"Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.""?",False, +19397332,Oxygen affects Hypoxemia,1557,"Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.","Is the triple ""Oxygen affects Hypoxemia"" supported by the sentence: ""Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.""?",False, +13060611,Oxygen affects Shock,1558,Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.,"Is the triple ""Oxygen affects Shock"" supported by the sentence: ""Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.""?",False, +13638133,Oxygen produces Hypoxemia,1559,"However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.","Is the triple ""Oxygen produces Hypoxemia"" supported by the sentence: ""However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.""?",False, +13264427,Oxygen produces neoplasm,1560,"The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.","Is the triple ""Oxygen produces neoplasm"" supported by the sentence: ""The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.""?",False, +12483211,Oxygen disrupts Hypoxemia,1561,Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.,"Is the triple ""Oxygen disrupts Hypoxemia"" supported by the sentence: ""Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.""?",False, +11682185,Oxygen disrupts neoplasm,1562,"While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.","Is the triple ""Oxygen disrupts neoplasm"" supported by the sentence: ""While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.""?",False, +16806319,Oxygen prevents injury,1563,"Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.","Is the triple ""Oxygen prevents injury"" supported by the sentence: ""Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.""?",False, +17280500,Oxygen predisposes injury,1564,"Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.","Is the triple ""Oxygen predisposes injury"" supported by the sentence: ""Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.""?",False, +7575686,Metoprolol subclass of O-Demethylmetoprolol,1565,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of O-Demethylmetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, +7575685,Metoprolol subclass of alpha-Hydroxymetoprolol,1566,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of alpha-Hydroxymetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, +27359356,Metoprolol related to alpha-Hydroxymetoprolol,1567,"When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.","Is the triple ""Metoprolol related to alpha-Hydroxymetoprolol"" supported by the sentence: ""When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.""?",False, +27639377,Metoprolol derives from alpha-Hydroxymetoprolol,1568,"METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.","Is the triple ""Metoprolol derives from alpha-Hydroxymetoprolol"" supported by the sentence: ""METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.""?",False, +26548288,Metoprolol physically interacts with O-Demethylmetoprolol,1569,"Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.","Is the triple ""Metoprolol physically interacts with O-Demethylmetoprolol"" supported by the sentence: ""Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.""?",False, +21656554,Metoprolol physically interacts with alpha-Hydroxymetoprolol,1570,Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.,"Is the triple ""Metoprolol physically interacts with alpha-Hydroxymetoprolol"" supported by the sentence: ""Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.""?",False, +27101524,Metoprolol causes ventricular tachycardia,1571,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular tachycardia"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, +27101519,Metoprolol causes ventricular fibrillation,1572,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular fibrillation"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, +20648435,Metoprolol causes cardiac rhythm disease,1573,"Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.","Is the triple ""Metoprolol causes cardiac rhythm disease"" supported by the sentence: ""Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.""?",False, +14625318,Metoprolol causes hypertensive disorder,1574,[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].,"Is the triple ""Metoprolol causes hypertensive disorder"" supported by the sentence: ""[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].""?",False, +19013861,Metoprolol affects obesity disorder,1575,"Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.","Is the triple ""Metoprolol affects obesity disorder"" supported by the sentence: ""Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.""?",False, +17630974,Metoprolol affects coronary artery disorder,1576,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects coronary artery disorder"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, +17630973,Metoprolol affects atherosclerosis,1577,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects atherosclerosis"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, +16547648,Metoprolol affects myocardial infarction,1578,Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.,"Is the triple ""Metoprolol affects myocardial infarction"" supported by the sentence: ""Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.""?",False, +12751741,Metoprolol affects cardiac rhythm disease,1579,"Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.","Is the triple ""Metoprolol affects cardiac rhythm disease"" supported by the sentence: ""Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.""?",False, +11341339,Metoprolol affects hypertensive disorder,1580,The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).,"Is the triple ""Metoprolol affects hypertensive disorder"" supported by the sentence: ""The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).""?",False, +16802112,Metoprolol disrupts atrial fibrillation,1581,CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.,"Is the triple ""Metoprolol disrupts atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.""?",False, +14314818,Metoprolol disrupts atherosclerosis,1582,"These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.","Is the triple ""Metoprolol disrupts atherosclerosis"" supported by the sentence: ""These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.""?",False, +13648308,Metoprolol disrupts ventricular tachycardia,1583,Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.,"Is the triple ""Metoprolol disrupts ventricular tachycardia"" supported by the sentence: ""Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.""?",False, +12510783,Metoprolol disrupts cardiac rhythm disease,1584,"However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.","Is the triple ""Metoprolol disrupts cardiac rhythm disease"" supported by the sentence: ""However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.""?",False, +16624344,Metoprolol prevents cardiac rhythm disease,1585,Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.,"Is the triple ""Metoprolol prevents cardiac rhythm disease"" supported by the sentence: ""Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.""?",False, +13530896,Metoprolol prevents myocardial infarction,1586,"POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.","Is the triple ""Metoprolol prevents myocardial infarction"" supported by the sentence: ""POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.""?",False, +13366014,Metoprolol prevents hypertensive disorder,1587,Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.,"Is the triple ""Metoprolol prevents hypertensive disorder"" supported by the sentence: ""Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.""?",False, +13268090,Metoprolol prevents ventricular fibrillation,1588,"CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.","Is the triple ""Metoprolol prevents ventricular fibrillation"" supported by the sentence: ""CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.""?",False, +9428080,Metoprolol prevents atrial fibrillation,1589,Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.,"Is the triple ""Metoprolol prevents atrial fibrillation"" supported by the sentence: ""Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.""?",False, +7236533,Metoprolol prevents atherosclerosis,1590,"The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.","Is the triple ""Metoprolol prevents atherosclerosis"" supported by the sentence: ""The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.""?",False, +22663349,Metoprolol predisposes atrial fibrillation,1591,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Metoprolol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, +25990864,Acebutolol affects hypertensive disorder,1592,The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.,"Is the triple ""Acebutolol affects hypertensive disorder"" supported by the sentence: ""The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.""?",False, +25995365,Acebutolol prevents hypertensive disorder,1593,"Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.","Is the triple ""Acebutolol prevents hypertensive disorder"" supported by the sentence: ""Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.""?",False, +24856753,Pretomanid affects multidrug-resistant tuberculosis,1594,"Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.","Is the triple ""Pretomanid affects multidrug-resistant tuberculosis"" supported by the sentence: ""Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.""?",False, +17848125,Nitrogen related to chronic obstructive pulmonary disease,1595,"Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.","Is the triple ""Nitrogen related to chronic obstructive pulmonary disease"" supported by the sentence: ""Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.""?",False, +15192685,Nitrogen related to ischemia reperfusion injury,1596,"Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.","Is the triple ""Nitrogen related to ischemia reperfusion injury"" supported by the sentence: ""Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.""?",False, +10505101,Nitrogen related to burn,1597,The effect on the nitrogen metabolism of severely burned patients.,"Is the triple ""Nitrogen related to burn"" supported by the sentence: ""The effect on the nitrogen metabolism of severely burned patients.""?",False, +10425490,Nitrogen related to cystic fibrosis,1598,Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.,"Is the triple ""Nitrogen related to cystic fibrosis"" supported by the sentence: ""Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.""?",False, +16934805,Nitrogen causes ischemia reperfusion injury,1599,"METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.","Is the triple ""Nitrogen causes ischemia reperfusion injury"" supported by the sentence: ""METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.""?",False, +13030867,Nitrogen affects ischemia reperfusion injury,1600,Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.,"Is the triple ""Nitrogen affects ischemia reperfusion injury"" supported by the sentence: ""Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.""?",False, +9020164,Nitrogen affects severe acute respiratory syndrome,1601,"The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.","Is the triple ""Nitrogen affects severe acute respiratory syndrome"" supported by the sentence: ""The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.""?",False, +17493096,Nitrogen predisposes ischemia reperfusion injury,1602,BACKGROUND: Nitrogen may contribute to reperfusion injury.,"Is the triple ""Nitrogen predisposes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Nitrogen may contribute to reperfusion injury.""?",False, +25313239,Helium related to status asthmaticus,1603,[Use of helium and oxygen mixtures in status asthmaticus].,"Is the triple ""Helium related to status asthmaticus"" supported by the sentence: ""[Use of helium and oxygen mixtures in status asthmaticus].""?",False, +12274245,Helium related to chronic obstructive pulmonary disease,1604,The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.,"Is the triple ""Helium related to chronic obstructive pulmonary disease"" supported by the sentence: ""The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.""?",False, +15248421,Carbon Dioxide related to Pain,1605,"Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.","Is the triple ""Carbon Dioxide related to Pain"" supported by the sentence: ""Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.""?",False, +11844945,Carbon Dioxide related to sleep apnea syndrome,1606,"Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.","Is the triple ""Carbon Dioxide related to sleep apnea syndrome"" supported by the sentence: ""Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.""?",False, +10575797,Carbon Dioxide related to respiratory failure,1607,Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.,"Is the triple ""Carbon Dioxide related to respiratory failure"" supported by the sentence: ""Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.""?",False, +7620110,Carbon Dioxide related to panic disorder,1608,To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.,"Is the triple ""Carbon Dioxide related to panic disorder"" supported by the sentence: ""To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.""?",False, +16671036,Carbon Dioxide causes panic disorder,1609,"We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.","Is the triple ""Carbon Dioxide causes panic disorder"" supported by the sentence: ""We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.""?",False, +11038318,Carbon Dioxide causes respiratory failure,1610,"BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.","Is the triple ""Carbon Dioxide causes respiratory failure"" supported by the sentence: ""BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.""?",False, +20071308,Carbon Dioxide affects Pain,1611,"INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.","Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.""?",False, +15771768,Carbon Dioxide affects Pain,1612,Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.,"Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.""?",False, +15385933,Carbon Dioxide affects panic disorder,1613,"In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.","Is the triple ""Carbon Dioxide affects panic disorder"" supported by the sentence: ""In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.""?",False, +14460813,Carbon Dioxide affects respiratory failure,1614,"Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.","Is the triple ""Carbon Dioxide affects respiratory failure"" supported by the sentence: ""Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.""?",False, +15294247,Carbon Dioxide produces respiratory failure,1615,"As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.","Is the triple ""Carbon Dioxide produces respiratory failure"" supported by the sentence: ""As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.""?",False, +11946282,Carbon Dioxide disrupts Pain,1616,BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.,"Is the triple ""Carbon Dioxide disrupts Pain"" supported by the sentence: ""BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.""?",False, +17126447,Carbon Dioxide predisposes Pain,1617,OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.,"Is the triple ""Carbon Dioxide predisposes Pain"" supported by the sentence: ""OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.""?",False, +11404382,Carbon Dioxide predisposes panic disorder,1618,"Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.","Is the triple ""Carbon Dioxide predisposes panic disorder"" supported by the sentence: ""Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.""?",False, +7432027,Carbon Dioxide predisposes respiratory failure,1619,"At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.","Is the triple ""Carbon Dioxide predisposes respiratory failure"" supported by the sentence: ""At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.""?",False, +24776228,Ethambutol causes tuberculosis,1620,From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.,"Is the triple ""Ethambutol causes tuberculosis"" supported by the sentence: ""From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.""?",False, +25946331,Ethambutol affects tuberculosis,1621,Effects of ethambutol on tuberculous diseases of the eye.,"Is the triple ""Ethambutol affects tuberculosis"" supported by the sentence: ""Effects of ethambutol on tuberculous diseases of the eye.""?",False, +24875144,Ethambutol affects pulmonary tuberculosis,1622,Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).,"Is the triple ""Ethambutol affects pulmonary tuberculosis"" supported by the sentence: ""Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).""?",False, +25597027,Ethambutol disrupts tuberculosis,1623,Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.,"Is the triple ""Ethambutol disrupts tuberculosis"" supported by the sentence: ""Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.""?",False, +18704735,Ethambutol prevents tuberculosis,1624,"After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.","Is the triple ""Ethambutol prevents tuberculosis"" supported by the sentence: ""After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.""?",False, +14472959,Pyrazinamide affects pulmonary tuberculosis,1625,Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.,"Is the triple ""Pyrazinamide affects pulmonary tuberculosis"" supported by the sentence: ""Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.""?",False, +10149898,Pyrazinamide affects tuberculosis,1626,Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.,"Is the triple ""Pyrazinamide affects tuberculosis"" supported by the sentence: ""Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.""?",False, +8080030,Pyrazinamide prevents tuberculosis,1627,Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.,"Is the triple ""Pyrazinamide prevents tuberculosis"" supported by the sentence: ""Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.""?",False, +27556045,Pyrazinamide predisposes tuberculosis,1628,"The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.","Is the triple ""Pyrazinamide predisposes tuberculosis"" supported by the sentence: ""The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.""?",False, +26376727,Androstanolone related to hypogonadism,1629,"The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.","Is the triple ""Androstanolone related to hypogonadism"" supported by the sentence: ""The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.""?",False, +22807780,Androstanolone affects hypogonadism,1630,"In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.","Is the triple ""Androstanolone affects hypogonadism"" supported by the sentence: ""In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.""?",False, +7261548,Nebivolol related to essential hypertension,1631,Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.,"Is the triple ""Nebivolol related to essential hypertension"" supported by the sentence: ""Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.""?",False, +10251853,Nebivolol affects hypertensive disorder,1632,In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.,"Is the triple ""Nebivolol affects hypertensive disorder"" supported by the sentence: ""In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.""?",False, +20026875,Nebivolol prevents cardiovascular disorder,1633,Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.,"Is the triple ""Nebivolol prevents cardiovascular disorder"" supported by the sentence: ""Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.""?",False, +10251855,Nebivolol prevents hypertensive disorder,1634,These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.,"Is the triple ""Nebivolol prevents hypertensive disorder"" supported by the sentence: ""These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.""?",False, +11558481,Nebivolol exacerbates hypertensive disorder,1635,"Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.","Is the triple ""Nebivolol exacerbates hypertensive disorder"" supported by the sentence: ""Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.""?",False, +17527026,Landiolol related to atrial fibrillation,1636,INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.,"Is the triple ""Landiolol related to atrial fibrillation"" supported by the sentence: ""INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.""?",False, +14267268,Landiolol affects atrial fibrillation,1637,The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.,"Is the triple ""Landiolol affects atrial fibrillation"" supported by the sentence: ""The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.""?",False, +16074351,Landiolol disrupts atrial fibrillation,1638,"RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).","Is the triple ""Landiolol disrupts atrial fibrillation"" supported by the sentence: ""RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).""?",False, +21882778,Landiolol prevents cardiac rhythm disease,1639,INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.,"Is the triple ""Landiolol prevents cardiac rhythm disease"" supported by the sentence: ""INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.""?",False, +14873276,Landiolol prevents atrial fibrillation,1640,"Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.","Is the triple ""Landiolol prevents atrial fibrillation"" supported by the sentence: ""Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.""?",False, +20190145,Landiolol predisposes atrial fibrillation,1641,"In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.","Is the triple ""Landiolol predisposes atrial fibrillation"" supported by the sentence: ""In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.""?",False, +26530979,Oxandrolone related to nutritional disorder,1642,"For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.","Is the triple ""Oxandrolone related to nutritional disorder"" supported by the sentence: ""For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.""?",False, +17138340,Oxandrolone related to Fanconi anemia,1643,"CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.","Is the triple ""Oxandrolone related to Fanconi anemia"" supported by the sentence: ""CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.""?",False, +12117784,Oxandrolone related to Turner syndrome,1644,"Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.","Is the triple ""Oxandrolone related to Turner syndrome"" supported by the sentence: ""Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.""?",False, +11269262,Oxandrolone related to burn,1645,The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.,"Is the triple ""Oxandrolone related to burn"" supported by the sentence: ""The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.""?",False, +7561027,Cefepime causes toxic shock syndrome,1646,"Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.","Is the triple ""Cefepime causes toxic shock syndrome"" supported by the sentence: ""Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.""?",False, +19437692,Cefepime affects bacterial infectious disease,1647,"OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.","Is the triple ""Cefepime affects bacterial infectious disease"" supported by the sentence: ""OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.""?",False, +17947468,Cefepime affects infectious disease,1648,"CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.","Is the triple ""Cefepime affects infectious disease"" supported by the sentence: ""CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.""?",False, +19800344,Cefepime disrupts infectious disease,1649,"CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.","Is the triple ""Cefepime disrupts infectious disease"" supported by the sentence: ""CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.""?",False, +26336145,"Hydrocortisone butyrate related to dermatitis, atopic",1650,[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].,"Is the triple ""Hydrocortisone butyrate related to dermatitis, atopic"" supported by the sentence: ""[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].""?",False, +26243703,Hydrocortisone butyrate related to skin disorder,1651,[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].,"Is the triple ""Hydrocortisone butyrate related to skin disorder"" supported by the sentence: ""[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].""?",False, +25968096,Hydrocortisone butyrate related to psoriasis,1652,Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.,"Is the triple ""Hydrocortisone butyrate related to psoriasis"" supported by the sentence: ""Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.""?",False, +17603464,Hydrocortisone butyrate disrupts psoriasis,1653,"Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.","Is the triple ""Hydrocortisone butyrate disrupts psoriasis"" supported by the sentence: ""Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.""?",False, +9729745,Adapalene related to acne,1654,The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.,"Is the triple ""Adapalene related to acne"" supported by the sentence: ""The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.""?",False, +8571018,Adapalene physically interacts with Retinoic Acid Receptor,1655,Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.,"Is the triple ""Adapalene physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.""?",False, +13523825,Retinol related to eye disorder,1656,"A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.","Is the triple ""Retinol related to eye disorder"" supported by the sentence: ""A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.""?",False, +11015290,Retinol related to tuberculosis,1657,[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].,"Is the triple ""Retinol related to tuberculosis"" supported by the sentence: ""[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].""?",False, +10457909,Retinol related to acne,1658,Vitamin A in acne vulgaris.,"Is the triple ""Retinol related to acne"" supported by the sentence: ""Vitamin A in acne vulgaris.""?",False, +8518043,Retinol related to malaria,1659,Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.,"Is the triple ""Retinol related to malaria"" supported by the sentence: ""Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.""?",False, +8137103,Retinol related to vitamin A deficiency,1660,"CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.","Is the triple ""Retinol related to vitamin A deficiency"" supported by the sentence: ""CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.""?",False, +7807614,Retinol related to retinitis pigmentosa,1661,"Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.","Is the triple ""Retinol related to retinitis pigmentosa"" supported by the sentence: ""Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.""?",False, +9304322,Retinol causes malaria,1662,"Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).","Is the triple ""Retinol causes malaria"" supported by the sentence: ""Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).""?",False, +27090494,Retinol affects diarrheal disease,1663,"However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.","Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.""?",False, +21959378,Retinol affects nutritional disorder,1664,Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.,"Is the triple ""Retinol affects nutritional disorder"" supported by the sentence: ""Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.""?",False, +17401879,Retinol affects tuberculosis,1665,"Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.","Is the triple ""Retinol affects tuberculosis"" supported by the sentence: ""Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.""?",False, +17082512,Retinol affects acne,1666,"Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.","Is the triple ""Retinol affects acne"" supported by the sentence: ""Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.""?",False, +12962972,Retinol affects eye disorder,1667,"The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.","Is the triple ""Retinol affects eye disorder"" supported by the sentence: ""The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.""?",False, +12534891,Retinol affects vitamin A deficiency,1668,The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.,"Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.""?",False, +11508263,Retinol affects diarrheal disease,1669,OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.,"Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.""?",False, +10941106,Retinol affects vitamin A deficiency,1670,"Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.","Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.""?",False, +22325993,Retinol produces Infection,1671,"As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).","Is the triple ""Retinol produces Infection"" supported by the sentence: ""As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).""?",False, +23772860,Retinol disrupts vitamin A deficiency,1672,"Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.","Is the triple ""Retinol disrupts vitamin A deficiency"" supported by the sentence: ""Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.""?",False, +12105339,Retinol disrupts diarrheal disease,1673,"Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.","Is the triple ""Retinol disrupts diarrheal disease"" supported by the sentence: ""Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.""?",False, +24823924,Retinol prevents Infection,1674,Vitamin A protects against infections and maintains epithelial integrity.,"Is the triple ""Retinol prevents Infection"" supported by the sentence: ""Vitamin A protects against infections and maintains epithelial integrity.""?",False, +17332605,Retinol prevents malaria,1675,CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.,"Is the triple ""Retinol prevents malaria"" supported by the sentence: ""CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.""?",False, +11445573,Retinol prevents nutritional disorder,1676,"Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.","Is the triple ""Retinol prevents nutritional disorder"" supported by the sentence: ""Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.""?",False, +8153477,Retinol prevents diarrheal disease,1677,"BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.","Is the triple ""Retinol prevents diarrheal disease"" supported by the sentence: ""BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.""?",False, +23860384,Retinol predisposes nutritional disorder,1678,"The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.","Is the triple ""Retinol predisposes nutritional disorder"" supported by the sentence: ""The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.""?",False, +19923430,Retinol predisposes malaria,1679,"We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.","Is the triple ""Retinol predisposes malaria"" supported by the sentence: ""We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.""?",False, +16391363,Retinol predisposes tuberculosis,1680,"A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.","Is the triple ""Retinol predisposes tuberculosis"" supported by the sentence: ""A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.""?",False, +15050082,Retinol predisposes diarrheal disease,1681,"Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.","Is the triple ""Retinol predisposes diarrheal disease"" supported by the sentence: ""Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.""?",False, +9744244,Retinol predisposes vitamin A deficiency,1682,"VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.","Is the triple ""Retinol predisposes vitamin A deficiency"" supported by the sentence: ""VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.""?",False, +18962170,Isotretinoin related to neuroblastoma,1683,We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.,"Is the triple ""Isotretinoin related to neuroblastoma"" supported by the sentence: ""We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.""?",False, +16229483,Isotretinoin related to brain cancer,1684,"Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.","Is the triple ""Isotretinoin related to brain cancer"" supported by the sentence: ""Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.""?",False, +15225681,Isotretinoin related to acne,1685,"The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.","Is the triple ""Isotretinoin related to acne"" supported by the sentence: ""The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.""?",False, +14091563,Isotretinoin related to myelodysplastic syndrome,1686,Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.,"Is the triple ""Isotretinoin related to myelodysplastic syndrome"" supported by the sentence: ""Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.""?",False, +9061344,Isotretinoin related to renal cell carcinoma,1687,BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).,"Is the triple ""Isotretinoin related to renal cell carcinoma"" supported by the sentence: ""BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).""?",False, +11768316,Isotretinoin physically interacts with Retinoic Acid Receptor,1688,"The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.","Is the triple ""Isotretinoin physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.""?",False, +21199868,Isotretinoin causes neuroblastoma,1689,"We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.","Is the triple ""Isotretinoin causes neuroblastoma"" supported by the sentence: ""We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.""?",False, +19803622,Isotretinoin causes acne,1690,Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.,"Is the triple ""Isotretinoin causes acne"" supported by the sentence: ""Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.""?",False, +19310397,Isotretinoin causes breast neoplasm,1691,Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.,"Is the triple ""Isotretinoin causes breast neoplasm"" supported by the sentence: ""Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.""?",False, +13522698,Isotretinoin causes neoplasm,1692,"We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.","Is the triple ""Isotretinoin causes neoplasm"" supported by the sentence: ""We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.""?",False, +23934527,Isotretinoin affects neoplasm,1693,"Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.""?",False, +20382078,Isotretinoin affects neuroblastoma,1694,"To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.","Is the triple ""Isotretinoin affects neuroblastoma"" supported by the sentence: ""To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.""?",False, +15927367,Isotretinoin affects rosacea,1695,"Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.","Is the triple ""Isotretinoin affects rosacea"" supported by the sentence: ""Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.""?",False, +15330626,Isotretinoin affects acne,1696,"In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.","Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.""?",False, +11212975,Isotretinoin affects neoplasm,1697,"CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.""?",False, +9764204,Isotretinoin affects acne,1698,Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.,"Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.""?",False, +21476432,Isotretinoin disrupts neuroblastoma,1699,Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.,"Is the triple ""Isotretinoin disrupts neuroblastoma"" supported by the sentence: ""Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.""?",False, +14724193,Isotretinoin disrupts neoplasm,1700,"Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.","Is the triple ""Isotretinoin disrupts neoplasm"" supported by the sentence: ""Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.""?",False, +14863864,Isotretinoin prevents acne,1701,"The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.","Is the triple ""Isotretinoin prevents acne"" supported by the sentence: ""The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.""?",False, +8312321,Isotretinoin prevents neoplasm,1702,Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.,"Is the triple ""Isotretinoin prevents neoplasm"" supported by the sentence: ""Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.""?",False, +15444114,Isotretinoin exacerbates ichthyosis,1703,We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.,"Is the triple ""Isotretinoin exacerbates ichthyosis"" supported by the sentence: ""We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.""?",False, +15310461,Isotretinoin predisposes acne,1704,"OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.","Is the triple ""Isotretinoin predisposes acne"" supported by the sentence: ""OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.""?",False, +24593446,Trifarotene affects acne,1705,The current review evaluates the role of trifarotene in treating acne.,"Is the triple ""Trifarotene affects acne"" supported by the sentence: ""The current review evaluates the role of trifarotene in treating acne.""?",False, +21448312,Atazanavir affects AIDS,1706,Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?,"Is the triple ""Atazanavir affects AIDS"" supported by the sentence: ""Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?""?",False, +24947472,Atazanavir disrupts HIV infectious disease,1707,"This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.","Is the triple ""Atazanavir disrupts HIV infectious disease"" supported by the sentence: ""This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.""?",False, +13198660,Atazanavir disrupts AIDS,1708,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Atazanavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, +20253995,Atazanavir prevents AIDS,1709,"Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.","Is the triple ""Atazanavir prevents AIDS"" supported by the sentence: ""Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.""?",False, +8134603,Saquinavir affects HIV infectious disease,1710,The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.,"Is the triple ""Saquinavir affects HIV infectious disease"" supported by the sentence: ""The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.""?",False, +16320598,Saquinavir disrupts viral infectious disease,1711,"SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.","Is the triple ""Saquinavir disrupts viral infectious disease"" supported by the sentence: ""SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.""?",False, +13198658,Saquinavir disrupts AIDS,1712,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Saquinavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, +17107608,Saquinavir prevents HIV infectious disease,1713,The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.,"Is the triple ""Saquinavir prevents HIV infectious disease"" supported by the sentence: ""The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.""?",False, +12560548,Indinavir prevents viral infectious disease,1714,Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.,"Is the triple ""Indinavir prevents viral infectious disease"" supported by the sentence: ""Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.""?",False, +15113750,Ritonavir related to AIDS,1715,Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.,"Is the triple ""Ritonavir related to AIDS"" supported by the sentence: ""Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.""?",False, +7566746,Ritonavir related to Cytochrome P-450 CYP3A,1716,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, +7566746,Ritonavir related to Cytochrome P-450 CYP3A,1717,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, +15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1718,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, +15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1719,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, +11500913,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1720,"In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).""?",False, +8329957,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1721,"Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.""?",False, +8452370,Ritonavir causes AIDS,1722,"Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.","Is the triple ""Ritonavir causes AIDS"" supported by the sentence: ""Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.""?",False, +21492333,Ritonavir affects neoplasm,1723,Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.,"Is the triple ""Ritonavir affects neoplasm"" supported by the sentence: ""Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.""?",False, +12140603,Ritonavir affects Insulin resistance,1724,"All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.","Is the triple ""Ritonavir affects Insulin resistance"" supported by the sentence: ""All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.""?",False, +9520105,Ritonavir affects HIV infectious disease,1725,This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.,"Is the triple ""Ritonavir affects HIV infectious disease"" supported by the sentence: ""This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.""?",False, +7566745,Ritonavir affects Cytochrome P-450 CYP3A,1726,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, +15873481,Ritonavir affects Cytochrome P-450 CYP3A,1727,"As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.""?",False, +21820102,Ritonavir disrupts Coronavinae infectious disease,1728,"Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.","Is the triple ""Ritonavir disrupts Coronavinae infectious disease"" supported by the sentence: ""Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.""?",False, +15656958,Ritonavir disrupts HIV infectious disease,1729,Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.,"Is the triple ""Ritonavir disrupts HIV infectious disease"" supported by the sentence: ""Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.""?",False, +9520113,Ritonavir disrupts neoplasm,1730,"In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.","Is the triple ""Ritonavir disrupts neoplasm"" supported by the sentence: ""In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.""?",False, +22737012,Ritonavir prevents neoplasm,1731,"Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.","Is the triple ""Ritonavir prevents neoplasm"" supported by the sentence: ""Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.""?",False, +10934319,Ritonavir prevents Kaposi's sarcoma,1732,The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.,"Is the triple ""Ritonavir prevents Kaposi's sarcoma"" supported by the sentence: ""The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.""?",False, +12915909,Nelfinavir causes diarrheal disease,1733,Does Roche's nelfinavir cause less diarrhea?,"Is the triple ""Nelfinavir causes diarrheal disease"" supported by the sentence: ""Does Roche's nelfinavir cause less diarrhea?""?",False, +19184628,Nelfinavir affects neoplasm,1734,"Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.","Is the triple ""Nelfinavir affects neoplasm"" supported by the sentence: ""Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.""?",False, +16087478,Nelfinavir affects plasma cell myeloma,1735,We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.,"Is the triple ""Nelfinavir affects plasma cell myeloma"" supported by the sentence: ""We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.""?",False, +11272488,Nelfinavir affects diarrheal disease,1736,"The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.","Is the triple ""Nelfinavir affects diarrheal disease"" supported by the sentence: ""The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.""?",False, +10940786,Thiopental affects brain injury,1737,"Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.","Is the triple ""Thiopental affects brain injury"" supported by the sentence: ""Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.""?",False, +7790675,Thiopental prevents brain injury,1738,"BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.","Is the triple ""Thiopental prevents brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.""?",False, +26262897,Pentobarbital causes insomnia,1739,The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.,"Is the triple ""Pentobarbital causes insomnia"" supported by the sentence: ""The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.""?",False, +25778415,Pentobarbital affects insomnia,1740,"Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""","Is the triple ""Pentobarbital affects insomnia"" supported by the sentence: ""Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""""?",False, +13642757,Pentobarbital disrupts status epilepticus,1741,"The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.","Is the triple ""Pentobarbital disrupts status epilepticus"" supported by the sentence: ""The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.""?",False, +23761012,Amobarbital prevents osteoarthritis,1742,"A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).","Is the triple ""Amobarbital prevents osteoarthritis"" supported by the sentence: ""A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).""?",False, +26983984,Moxisylyte causes erectile dysfunction,1743,"Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.","Is the triple ""Moxisylyte causes erectile dysfunction"" supported by the sentence: ""Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.""?",False, +26385811,Mepyramine prevents allergic disease,1744,Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).,"Is the triple ""Mepyramine prevents allergic disease"" supported by the sentence: ""Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).""?",False, +27140633,Promethazine subclass of Promethazine sulfoxide,1745,Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.,"Is the triple ""Promethazine subclass of Promethazine sulfoxide"" supported by the sentence: ""Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.""?",False, +19124534,Promethazine related to Vomiting,1746,"A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.","Is the triple ""Promethazine related to Vomiting"" supported by the sentence: ""A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.""?",False, +26252918,Promethazine causes Vomiting,1747,"Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.","Is the triple ""Promethazine causes Vomiting"" supported by the sentence: ""Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.""?",False, +8157500,Promethazine causes depressive disorder,1748,Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.,"Is the triple ""Promethazine causes depressive disorder"" supported by the sentence: ""Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.""?",False, +19547748,Promethazine affects Vomiting,1749,"The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).""?",False, +12404928,Promethazine affects Pruritus,1750,"Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.","Is the triple ""Promethazine affects Pruritus"" supported by the sentence: ""Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.""?",False, +10742218,Promethazine affects Nausea,1751,The effect of promethazine in nausea and vomiting of pregnancy.,"Is the triple ""Promethazine affects Nausea"" supported by the sentence: ""The effect of promethazine in nausea and vomiting of pregnancy.""?",False, +10228295,Promethazine affects central nervous system origin vertigo,1752,"We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.","Is the triple ""Promethazine affects central nervous system origin vertigo"" supported by the sentence: ""We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.""?",False, +7912966,Promethazine affects Vomiting,1753,"STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.""?",False, +13616931,Promethazine disrupts Nausea,1754,"Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).","Is the triple ""Promethazine disrupts Nausea"" supported by the sentence: ""Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).""?",False, +17497020,Promethazine prevents central nervous system origin vertigo,1755,OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.,"Is the triple ""Promethazine prevents central nervous system origin vertigo"" supported by the sentence: ""OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.""?",False, +11541778,Promethazine prevents Pruritus,1756,RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.,"Is the triple ""Promethazine prevents Pruritus"" supported by the sentence: ""RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.""?",False, +7912965,Promethazine prevents Vomiting,1757,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Vomiting"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, +7912964,Promethazine prevents Nausea,1758,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Nausea"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, +25750000,Clemastine causes urticaria,1759,"The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.","Is the triple ""Clemastine causes urticaria"" supported by the sentence: ""The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.""?",False, +25747466,Clemastine affects urticaria,1760,"The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.","Is the triple ""Clemastine affects urticaria"" supported by the sentence: ""The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.""?",False, +19433677,Clemastine affects Pruritus,1761,"The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.","Is the triple ""Clemastine affects Pruritus"" supported by the sentence: ""The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.""?",False, +25634655,Clemastine disrupts urticaria,1762,"Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.","Is the triple ""Clemastine disrupts urticaria"" supported by the sentence: ""Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.""?",False, +24612586,Clemastine prevents urticaria,1763,"An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.","Is the triple ""Clemastine prevents urticaria"" supported by the sentence: ""An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.""?",False, +17916924,Clemastine prevents dermatitis,1764,"The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.","Is the triple ""Clemastine prevents dermatitis"" supported by the sentence: ""The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.""?",False, +24699384,Clemastine predisposes allergic disease,1765,"To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.","Is the triple ""Clemastine predisposes allergic disease"" supported by the sentence: ""To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.""?",False, +25081855,Tiapride affects Dopamine D2 Receptor,1766,"Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.","Is the triple ""Tiapride affects Dopamine D2 Receptor"" supported by the sentence: ""Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.""?",False, +19553406,Amisulpride causes schizophrenia,1767,rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.,"Is the triple ""Amisulpride causes schizophrenia"" supported by the sentence: ""rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.""?",False, +9337142,Amisulpride causes psychotic disorder,1768,"Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.","Is the triple ""Amisulpride causes psychotic disorder"" supported by the sentence: ""Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.""?",False, +24415555,Amisulpride affects depressive disorder,1769,"The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.","Is the triple ""Amisulpride affects depressive disorder"" supported by the sentence: ""The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.""?",False, +8493076,Amisulpride affects schizophrenia,1770,"In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.","Is the triple ""Amisulpride affects schizophrenia"" supported by the sentence: ""In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.""?",False, +20532376,Amisulpride prevents Postoperative Nausea and Vomiting,1771,"Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.","Is the triple ""Amisulpride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.""?",False, +19821343,Amisulpride prevents Nausea,1772,Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.,"Is the triple ""Amisulpride prevents Nausea"" supported by the sentence: ""Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.""?",False, +11149280,Remoxipride physically interacts with Dopamine D2 Receptor,1773,Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.,"Is the triple ""Remoxipride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.""?",False, +9174370,Remoxipride affects Dopamine D2 Receptor,1774,Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.,"Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.""?",False, +24158881,Remoxipride affects Dopamine D2 Receptor,1775,"Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.","Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.""?",False, +20394421,Levosulpiride affects Dopamine D2 Receptor,1776,"Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.","Is the triple ""Levosulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.""?",False, +26880772,Nitroglycerin related to coronary artery disorder,1777,Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.,"Is the triple ""Nitroglycerin related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.""?",False, +26139329,Nitroglycerin related to hypertensive disorder,1778,A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.,"Is the triple ""Nitroglycerin related to hypertensive disorder"" supported by the sentence: ""A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.""?",False, +21173297,Nitroglycerin related to injury,1779,"Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.","Is the triple ""Nitroglycerin related to injury"" supported by the sentence: ""Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.""?",False, +26585664,Nitroglycerin causes Raynaud disease,1780,Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.,"Is the triple ""Nitroglycerin causes Raynaud disease"" supported by the sentence: ""Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.""?",False, +26278376,Nitroglycerin causes Angina pectoris,1781,Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.,"Is the triple ""Nitroglycerin causes Angina pectoris"" supported by the sentence: ""Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.""?",False, +26148974,Nitroglycerin causes myocardial infarction,1782,Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.,"Is the triple ""Nitroglycerin causes myocardial infarction"" supported by the sentence: ""Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.""?",False, +15949436,Nitroglycerin causes injury,1783,"If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.","Is the triple ""Nitroglycerin causes injury"" supported by the sentence: ""If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.""?",False, +15624022,Nitroglycerin causes Inflammation,1784,Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.,"Is the triple ""Nitroglycerin causes Inflammation"" supported by the sentence: ""Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.""?",False, +14985558,Nitroglycerin causes hypertensive disorder,1785,STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.,"Is the triple ""Nitroglycerin causes hypertensive disorder"" supported by the sentence: ""STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.""?",False, +8402702,Nitroglycerin causes Pain,1786,Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.,"Is the triple ""Nitroglycerin causes Pain"" supported by the sentence: ""Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.""?",False, +7629693,Nitroglycerin causes hypotensive disorder,1787,"In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.","Is the triple ""Nitroglycerin causes hypotensive disorder"" supported by the sentence: ""In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.""?",False, +26786108,Nitroglycerin affects coronary artery disorder,1788,Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.""?",False, +26278652,Nitroglycerin affects hypotensive disorder,1789,"This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.","Is the triple ""Nitroglycerin affects hypotensive disorder"" supported by the sentence: ""This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.""?",False, +25994904,Nitroglycerin affects Raynaud disease,1790,"The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.","Is the triple ""Nitroglycerin affects Raynaud disease"" supported by the sentence: ""The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.""?",False, +25747829,Nitroglycerin affects erectile dysfunction,1791,Impotence responsive to glyceryl trinitrate.,"Is the triple ""Nitroglycerin affects erectile dysfunction"" supported by the sentence: ""Impotence responsive to glyceryl trinitrate.""?",False, +25260538,Nitroglycerin affects Muscle spasm,1792,Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.,"Is the triple ""Nitroglycerin affects Muscle spasm"" supported by the sentence: ""Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.""?",False, +23178151,Nitroglycerin affects coronary artery disorder,1793,Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.""?",False, +20885558,Nitroglycerin affects injury,1794,Cardiac output effects of nitroglycerin in experimental lung injury.,"Is the triple ""Nitroglycerin affects injury"" supported by the sentence: ""Cardiac output effects of nitroglycerin in experimental lung injury.""?",False, +18491008,Nitroglycerin affects Hot flashes,1795,"After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).","Is the triple ""Nitroglycerin affects Hot flashes"" supported by the sentence: ""After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).""?",False, +14421188,Nitroglycerin affects Angina pectoris,1796,"Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).","Is the triple ""Nitroglycerin affects Angina pectoris"" supported by the sentence: ""Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).""?",False, +13478654,Nitroglycerin affects osteoporosis,1797,The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.,"Is the triple ""Nitroglycerin affects osteoporosis"" supported by the sentence: ""The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.""?",False, +11707783,Nitroglycerin affects Pain,1798,"We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.","Is the triple ""Nitroglycerin affects Pain"" supported by the sentence: ""We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.""?",False, +11174035,Nitroglycerin affects hypertensive disorder,1799,"The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.","Is the triple ""Nitroglycerin affects hypertensive disorder"" supported by the sentence: ""The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.""?",False, +10595566,Nitroglycerin affects stroke disorder,1800,[On the effect of nitroglycerin on the stroke- and minute volume of the heart].,"Is the triple ""Nitroglycerin affects stroke disorder"" supported by the sentence: ""[On the effect of nitroglycerin on the stroke- and minute volume of the heart].""?",False, +8601510,Nitroglycerin affects myocardial ischemia,1801,Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.,"Is the triple ""Nitroglycerin affects myocardial ischemia"" supported by the sentence: ""Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.""?",False, +8521770,Nitroglycerin affects phlebitis,1802,Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.,"Is the triple ""Nitroglycerin affects phlebitis"" supported by the sentence: ""Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.""?",False, +8049127,Nitroglycerin affects ischemia reperfusion injury,1803,Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.,"Is the triple ""Nitroglycerin affects ischemia reperfusion injury"" supported by the sentence: ""Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.""?",False, +26813951,Nitroglycerin disrupts myocardial ischemia,1804,Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.,"Is the triple ""Nitroglycerin disrupts myocardial ischemia"" supported by the sentence: ""Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.""?",False, +26590847,Nitroglycerin disrupts hypertensive disorder,1805,"CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.","Is the triple ""Nitroglycerin disrupts hypertensive disorder"" supported by the sentence: ""CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.""?",False, +24386334,Nitroglycerin disrupts phlebitis,1806,"The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).","Is the triple ""Nitroglycerin disrupts phlebitis"" supported by the sentence: ""The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).""?",False, +19274234,Nitroglycerin disrupts injury,1807,"Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.","Is the triple ""Nitroglycerin disrupts injury"" supported by the sentence: ""Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.""?",False, +10081147,Nitroglycerin disrupts Marchiafava-Bignami disease,1808,These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.,"Is the triple ""Nitroglycerin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.""?",False, +9796564,Nitroglycerin disrupts Pain,1809,At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.,"Is the triple ""Nitroglycerin disrupts Pain"" supported by the sentence: ""At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.""?",False, +25569906,Nitroglycerin prevents phlebitis,1810,CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.,"Is the triple ""Nitroglycerin prevents phlebitis"" supported by the sentence: ""CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.""?",False, +21983895,Nitroglycerin prevents Muscle spasm,1811,Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.,"Is the triple ""Nitroglycerin prevents Muscle spasm"" supported by the sentence: ""Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.""?",False, +20473117,Nitroglycerin prevents Inflammation,1812,Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.,"Is the triple ""Nitroglycerin prevents Inflammation"" supported by the sentence: ""Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.""?",False, +18491009,Nitroglycerin prevents Hot flashes,1813,CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.,"Is the triple ""Nitroglycerin prevents Hot flashes"" supported by the sentence: ""CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.""?",False, +17804368,Nitroglycerin prevents hypertensive disorder,1814,"Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.","Is the triple ""Nitroglycerin prevents hypertensive disorder"" supported by the sentence: ""Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.""?",False, +11496690,Nitroglycerin prevents ischemia reperfusion injury,1815,CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.,"Is the triple ""Nitroglycerin prevents ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.""?",False, +10695579,Nitroglycerin prevents Angina pectoris,1816,A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.,"Is the triple ""Nitroglycerin prevents Angina pectoris"" supported by the sentence: ""A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.""?",False, +10573276,Nitroglycerin prevents myocardial infarction,1817,Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.,"Is the triple ""Nitroglycerin prevents myocardial infarction"" supported by the sentence: ""Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.""?",False, +9096899,Nitroglycerin prevents Pain,1818,Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.,"Is the triple ""Nitroglycerin prevents Pain"" supported by the sentence: ""Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.""?",False, +9057729,Nitroglycerin prevents Shock,1819,"Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).","Is the triple ""Nitroglycerin prevents Shock"" supported by the sentence: ""Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).""?",False, +8235862,Nitroglycerin prevents Marchiafava-Bignami disease,1820,"Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).","Is the triple ""Nitroglycerin prevents Marchiafava-Bignami disease"" supported by the sentence: ""Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).""?",False, +7713034,Nitroglycerin prevents injury,1821,"It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.","Is the triple ""Nitroglycerin prevents injury"" supported by the sentence: ""It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.""?",False, +13750741,Nitroglycerin exacerbates myocardial ischemia,1822,"RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).","Is the triple ""Nitroglycerin exacerbates myocardial ischemia"" supported by the sentence: ""RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).""?",False, +20483551,Nitroglycerin predisposes myocardial ischemia,1823,OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.,"Is the triple ""Nitroglycerin predisposes myocardial ischemia"" supported by the sentence: ""OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.""?",False, +9897513,Nitroglycerin predisposes Angina pectoris,1824,Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.,"Is the triple ""Nitroglycerin predisposes Angina pectoris"" supported by the sentence: ""Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.""?",False, +20924645,Isosorbide dinitrate related to myocardial ischemia,1825,Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.,"Is the triple ""Isosorbide dinitrate related to myocardial ischemia"" supported by the sentence: ""Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.""?",False, +10616906,Isosorbide dinitrate related to Angina pectoris,1826,Isosorbide dinitrate in angina pectoris.,"Is the triple ""Isosorbide dinitrate related to Angina pectoris"" supported by the sentence: ""Isosorbide dinitrate in angina pectoris.""?",False, +9112334,Isosorbide dinitrate related to coronary artery disorder,1827,Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.,"Is the triple ""Isosorbide dinitrate related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.""?",False, +26334868,Isosorbide dinitrate affects Angina pectoris,1828,The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.,"Is the triple ""Isosorbide dinitrate affects Angina pectoris"" supported by the sentence: ""The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.""?",False, +10884689,Isosorbide dinitrate affects myocardial ischemia,1829,The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.,"Is the triple ""Isosorbide dinitrate affects myocardial ischemia"" supported by the sentence: ""The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.""?",False, +9112335,Isosorbide dinitrate prevents myocardial ischemia,1830,"To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.","Is the triple ""Isosorbide dinitrate prevents myocardial ischemia"" supported by the sentence: ""To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.""?",False, +17782283,Sulpiride physically interacts with Dopamine D2 Receptor,1831,"The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.""?",False, +7084056,Sulpiride physically interacts with Dopamine D2 Receptor,1832,"Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.""?",False, +25690684,Sulpiride causes depressive disorder,1833,"Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.","Is the triple ""Sulpiride causes depressive disorder"" supported by the sentence: ""Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.""?",False, +26343015,Sulpiride affects schizophrenia,1834,"On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.","Is the triple ""Sulpiride affects schizophrenia"" supported by the sentence: ""On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.""?",False, +23882267,Sulpiride affects anxiety,1835,Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.,"Is the triple ""Sulpiride affects anxiety"" supported by the sentence: ""Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.""?",False, +8960439,Sulpiride affects depressive disorder,1836,"This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.""?",False, +8364166,Sulpiride affects Dopamine D2 Receptor,1837,"Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.","Is the triple ""Sulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.""?",False, +7538297,Sulpiride affects depressive disorder,1838,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, +25756981,Sulpiride disrupts depressive disorder,1839,"(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.","Is the triple ""Sulpiride disrupts depressive disorder"" supported by the sentence: ""(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.""?",False, +8859505,Sulpiride disrupts anxiety,1840,"Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.","Is the triple ""Sulpiride disrupts anxiety"" supported by the sentence: ""Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.""?",False, +26753868,Isosorbide mononitrate causes Angina pectoris,1841,"To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.","Is the triple ""Isosorbide mononitrate causes Angina pectoris"" supported by the sentence: ""To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.""?",False, +15856723,Isosorbide mononitrate affects Angina pectoris,1842,Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.,"Is the triple ""Isosorbide mononitrate affects Angina pectoris"" supported by the sentence: ""Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.""?",False, +24979081,Isosorbide mononitrate prevents vascular disorder,1843,METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.,"Is the triple ""Isosorbide mononitrate prevents vascular disorder"" supported by the sentence: ""METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.""?",False, +22319748,Isosorbide mononitrate prevents Angina pectoris,1844,"Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.","Is the triple ""Isosorbide mononitrate prevents Angina pectoris"" supported by the sentence: ""Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.""?",False, +23203614,Ribociclib related to squamous cell carcinoma,1845,"Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.","Is the triple ""Ribociclib related to squamous cell carcinoma"" supported by the sentence: ""Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.""?",False, +23890460,Abemaciclib related to non-small cell lung carcinoma,1846,Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.,"Is the triple ""Abemaciclib related to non-small cell lung carcinoma"" supported by the sentence: ""Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.""?",False, +24133672,Abemaciclib affects neoplasm,1847,"We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.","Is the triple ""Abemaciclib affects neoplasm"" supported by the sentence: ""We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.""?",False, +23820208,Abemaciclib disrupts neoplasm,1848,Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.,"Is the triple ""Abemaciclib disrupts neoplasm"" supported by the sentence: ""Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.""?",False, +7114439,Sodium Chloride subclass of Electrolytes,1849,"LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.","Is the triple ""Sodium Chloride subclass of Electrolytes"" supported by the sentence: ""LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.""?",False, +27178225,Sodium Chloride related to hypoglycemia,1850,Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.,"Is the triple ""Sodium Chloride related to hypoglycemia"" supported by the sentence: ""Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.""?",False, +26906663,Sodium Chloride related to ventricular septal defect,1851,"When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).","Is the triple ""Sodium Chloride related to ventricular septal defect"" supported by the sentence: ""When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).""?",False, +26538206,Sodium Chloride related to papilloma,1852,The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.,"Is the triple ""Sodium Chloride related to papilloma"" supported by the sentence: ""The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.""?",False, +26529472,Sodium Chloride related to chronic obstructive pulmonary disease,1853,"Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.","Is the triple ""Sodium Chloride related to chronic obstructive pulmonary disease"" supported by the sentence: ""Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.""?",False, +26267091,Sodium Chloride related to Sepsis,1854,"The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.","Is the triple ""Sodium Chloride related to Sepsis"" supported by the sentence: ""The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.""?",False, +26209731,Sodium Chloride related to cataract,1855,Basic data supporting the use of the l-lysine salt of bendazac in cataract.,"Is the triple ""Sodium Chloride related to cataract"" supported by the sentence: ""Basic data supporting the use of the l-lysine salt of bendazac in cataract.""?",False, +25917183,Sodium Chloride related to Hypoxemia,1856,[Effect of vitamin C on water-salt metabolism in experimental hypoxia].,"Is the triple ""Sodium Chloride related to Hypoxemia"" supported by the sentence: ""[Effect of vitamin C on water-salt metabolism in experimental hypoxia].""?",False, +20673450,Sodium Chloride related to Alzheimer disease,1857,The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.,"Is the triple ""Sodium Chloride related to Alzheimer disease"" supported by the sentence: ""The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.""?",False, +20617514,Sodium Chloride related to type 2 diabetes mellitus,1858,"Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.","Is the triple ""Sodium Chloride related to type 2 diabetes mellitus"" supported by the sentence: ""Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.""?",False, +20321366,Sodium Chloride related to type 1 diabetes mellitus,1859,"In addition, NEN could impede the progression of DKD in T1D.","Is the triple ""Sodium Chloride related to type 1 diabetes mellitus"" supported by the sentence: ""In addition, NEN could impede the progression of DKD in T1D.""?",False, +19962817,Sodium Chloride related to Inflammation,1860,"These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.","Is the triple ""Sodium Chloride related to Inflammation"" supported by the sentence: ""These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.""?",False, +19891172,Sodium Chloride related to acute lung injury,1861,BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.,"Is the triple ""Sodium Chloride related to acute lung injury"" supported by the sentence: ""BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.""?",False, +19636264,Sodium Chloride related to ischemic disease,1862,"Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.","Is the triple ""Sodium Chloride related to ischemic disease"" supported by the sentence: ""Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.""?",False, +19577743,Sodium Chloride related to spinal cord injury,1863,OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.,"Is the triple ""Sodium Chloride related to spinal cord injury"" supported by the sentence: ""OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.""?",False, +19497082,Sodium Chloride related to primary ciliary dyskinesia,1864,A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.,"Is the triple ""Sodium Chloride related to primary ciliary dyskinesia"" supported by the sentence: ""A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.""?",False, +18975700,Sodium Chloride related to bacterial infectious disease,1865,Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.,"Is the triple ""Sodium Chloride related to bacterial infectious disease"" supported by the sentence: ""Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.""?",False, +18966398,Sodium Chloride related to osteoarthritis,1866,"CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.","Is the triple ""Sodium Chloride related to osteoarthritis"" supported by the sentence: ""CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.""?",False, +18860303,Sodium Chloride related to bone fracture,1867,Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).,"Is the triple ""Sodium Chloride related to bone fracture"" supported by the sentence: ""Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).""?",False, +18738706,Sodium Chloride related to toxic shock syndrome,1868,CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.,"Is the triple ""Sodium Chloride related to toxic shock syndrome"" supported by the sentence: ""CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.""?",False, +18679247,Sodium Chloride related to Electrolytes,1869,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, +18617363,Sodium Chloride related to iron deficiency anemia,1870,"At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.","Is the triple ""Sodium Chloride related to iron deficiency anemia"" supported by the sentence: ""At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.""?",False, +18287282,Sodium Chloride related to Pruritus,1871,"The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).","Is the triple ""Sodium Chloride related to Pruritus"" supported by the sentence: ""The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).""?",False, +17603340,Sodium Chloride related to brain injury,1872,Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.,"Is the triple ""Sodium Chloride related to brain injury"" supported by the sentence: ""Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.""?",False, +17533385,Sodium Chloride related to myocardial infarction,1873,Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.,"Is the triple ""Sodium Chloride related to myocardial infarction"" supported by the sentence: ""Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.""?",False, +17525035,Sodium Chloride related to coronary artery disorder,1874,The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.,"Is the triple ""Sodium Chloride related to coronary artery disorder"" supported by the sentence: ""The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.""?",False, +17213013,Sodium Chloride related to hepatocellular carcinoma,1875,"In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.","Is the triple ""Sodium Chloride related to hepatocellular carcinoma"" supported by the sentence: ""In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.""?",False, +17202845,Sodium Chloride related to Parkinson disease,1876,These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.,"Is the triple ""Sodium Chloride related to Parkinson disease"" supported by the sentence: ""These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.""?",False, +16886803,Sodium Chloride related to ischemia reperfusion injury,1877,Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.,"Is the triple ""Sodium Chloride related to ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.""?",False, +16594665,Sodium Chloride related to Pain,1878,"In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.","Is the triple ""Sodium Chloride related to Pain"" supported by the sentence: ""In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.""?",False, +16433967,Sodium Chloride related to liver and intrahepatic bile duct neoplasm,1879,Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.,"Is the triple ""Sodium Chloride related to liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.""?",False, +15412515,Sodium Chloride related to subarachnoid hemorrhage,1880,Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).,"Is the triple ""Sodium Chloride related to subarachnoid hemorrhage"" supported by the sentence: ""Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).""?",False, +14710472,Sodium Chloride related to bronchiolitis,1881,"High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.","Is the triple ""Sodium Chloride related to bronchiolitis"" supported by the sentence: ""High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.""?",False, +14037713,Sodium Chloride related to ventricular tachycardia,1882,"Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.","Is the triple ""Sodium Chloride related to ventricular tachycardia"" supported by the sentence: ""Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.""?",False, +13928740,Sodium Chloride related to pulmonary edema,1883,"Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.","Is the triple ""Sodium Chloride related to pulmonary edema"" supported by the sentence: ""Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.""?",False, +13375642,Sodium Chloride related to Insulin resistance,1884,"CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.","Is the triple ""Sodium Chloride related to Insulin resistance"" supported by the sentence: ""CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.""?",False, +13343201,Sodium Chloride related to Hypernatremia,1885,CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.,"Is the triple ""Sodium Chloride related to Hypernatremia"" supported by the sentence: ""CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.""?",False, +13277977,Sodium Chloride related to diabetic ketoacidosis,1886,The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.,"Is the triple ""Sodium Chloride related to diabetic ketoacidosis"" supported by the sentence: ""The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.""?",False, +11905993,Sodium Chloride related to depressive disorder,1887,"This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.","Is the triple ""Sodium Chloride related to depressive disorder"" supported by the sentence: ""This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.""?",False, +11014479,Sodium Chloride related to glaucoma,1888,[Dynamics of sodium chloride in the blood in glaucoma].,"Is the triple ""Sodium Chloride related to glaucoma"" supported by the sentence: ""[Dynamics of sodium chloride in the blood in glaucoma].""?",False, +10966302,Sodium Chloride related to malaria,1889,"Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.","Is the triple ""Sodium Chloride related to malaria"" supported by the sentence: ""Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.""?",False, +10739226,Sodium Chloride related to heart disorder,1890,[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].,"Is the triple ""Sodium Chloride related to heart disorder"" supported by the sentence: ""[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].""?",False, +10689901,Sodium Chloride related to diabetes mellitus,1891,[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].,"Is the triple ""Sodium Chloride related to diabetes mellitus"" supported by the sentence: ""[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].""?",False, +10566407,Sodium Chloride related to brain cancer,1892,[Water-salt and carbohydrate metabolism in brain tumors].,"Is the triple ""Sodium Chloride related to brain cancer"" supported by the sentence: ""[Water-salt and carbohydrate metabolism in brain tumors].""?",False, +10531148,Sodium Chloride related to kidney failure,1893,"[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].","Is the triple ""Sodium Chloride related to kidney failure"" supported by the sentence: ""[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].""?",False, +10510273,Sodium Chloride related to Shock,1894,[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].,"Is the triple ""Sodium Chloride related to Shock"" supported by the sentence: ""[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].""?",False, +10504585,Sodium Chloride related to tuberculosis,1895,[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].,"Is the triple ""Sodium Chloride related to tuberculosis"" supported by the sentence: ""[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].""?",False, +10502982,Sodium Chloride related to nutritional disorder,1896,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to nutritional disorder"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, +10502981,Sodium Chloride related to cirrhosis of liver,1897,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to cirrhosis of liver"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, +10487095,Sodium Chloride related to pneumonia,1898,[Water and salt content in the lung in vagus pneumonia].,"Is the triple ""Sodium Chloride related to pneumonia"" supported by the sentence: ""[Water and salt content in the lung in vagus pneumonia].""?",False, +10439781,Sodium Chloride related to acute kidney failure,1899,Patterns of renal salt loss in acute renal failure.,"Is the triple ""Sodium Chloride related to acute kidney failure"" supported by the sentence: ""Patterns of renal salt loss in acute renal failure.""?",False, +10433628,Sodium Chloride related to psoriasis,1900,[Studies on water and salt metabolism in psoriasis].,"Is the triple ""Sodium Chloride related to psoriasis"" supported by the sentence: ""[Studies on water and salt metabolism in psoriasis].""?",False, +10370762,Sodium Chloride related to Hypothermia,1901,[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].,"Is the triple ""Sodium Chloride related to Hypothermia"" supported by the sentence: ""[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].""?",False, +10318383,Sodium Chloride related to cardiovascular disorder,1902,Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.,"Is the triple ""Sodium Chloride related to cardiovascular disorder"" supported by the sentence: ""Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.""?",False, +10300324,Sodium Chloride related to stroke disorder,1903,"Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).","Is the triple ""Sodium Chloride related to stroke disorder"" supported by the sentence: ""Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).""?",False, +10268953,Sodium Chloride related to brain edema,1904,"The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.","Is the triple ""Sodium Chloride related to brain edema"" supported by the sentence: ""The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.""?",False, +9985623,Sodium Chloride related to Nausea,1905,"Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.","Is the triple ""Sodium Chloride related to Nausea"" supported by the sentence: ""Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.""?",False, +9642141,Sodium Chloride related to obesity disorder,1906,"The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).","Is the triple ""Sodium Chloride related to obesity disorder"" supported by the sentence: ""The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).""?",False, +9504754,Sodium Chloride related to asthma,1907,Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.,"Is the triple ""Sodium Chloride related to asthma"" supported by the sentence: ""Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.""?",False, +9350794,Sodium Chloride related to essential hypertension,1908,[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].,"Is the triple ""Sodium Chloride related to essential hypertension"" supported by the sentence: ""[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].""?",False, +9217528,Sodium Chloride related to dry eye syndrome,1909,The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.,"Is the triple ""Sodium Chloride related to dry eye syndrome"" supported by the sentence: ""The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.""?",False, +8489872,Sodium Chloride related to injury,1910,Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.,"Is the triple ""Sodium Chloride related to injury"" supported by the sentence: ""Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.""?",False, +8486278,Sodium Chloride related to cystic fibrosis,1911,"We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.","Is the triple ""Sodium Chloride related to cystic fibrosis"" supported by the sentence: ""We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.""?",False, +7822303,Sodium Chloride related to neoplasm,1912,"Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.","Is the triple ""Sodium Chloride related to neoplasm"" supported by the sentence: ""Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.""?",False, +7455347,Sodium Chloride related to Hypovolemia,1913,"It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.","Is the triple ""Sodium Chloride related to Hypovolemia"" supported by the sentence: ""It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.""?",False, +7397406,Sodium Chloride related to kidney disorder,1914,Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.,"Is the triple ""Sodium Chloride related to kidney disorder"" supported by the sentence: ""Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.""?",False, +7259411,Sodium Chloride related to hypertensive disorder,1915,"Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.","Is the triple ""Sodium Chloride related to hypertensive disorder"" supported by the sentence: ""Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.""?",False, +19769676,Sodium Chloride related to Electrolytes,1916,"Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.","Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.""?",False, +18679248,Sodium Chloride close match Electrolytes,1917,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride close match Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, +7792933,Sodium Chloride coexists with Electrolytes,1918,"Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).","Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).""?",False, +9181325,Sodium Chloride coexists with Electrolytes,1919,Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.,"Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.""?",False, +27223278,Sodium Chloride derives from Electrolytes,1920,The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.,"Is the triple ""Sodium Chloride derives from Electrolytes"" supported by the sentence: ""The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.""?",False, +9585905,Sodium Chloride physically interacts with Electrolytes,1921,"The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.""?",False, +9585904,Sodium Chloride physically interacts with Electrolytes,1922,"The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.""?",False, +26947391,Sodium Chloride causes acute kidney tubular necrosis,1923,"Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).","Is the triple ""Sodium Chloride causes acute kidney tubular necrosis"" supported by the sentence: ""Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).""?",False, +26813055,Sodium Chloride causes Dyspnea,1924,"When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.","Is the triple ""Sodium Chloride causes Dyspnea"" supported by the sentence: ""When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.""?",False, +26651944,Sodium Chloride causes severe cutaneous adverse reaction,1925,In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.,"Is the triple ""Sodium Chloride causes severe cutaneous adverse reaction"" supported by the sentence: ""In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.""?",False, +26200221,Sodium Chloride causes melanoma,1926,In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.,"Is the triple ""Sodium Chloride causes melanoma"" supported by the sentence: ""In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.""?",False, +25963723,Sodium Chloride causes cardiac arrest,1927,Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.,"Is the triple ""Sodium Chloride causes cardiac arrest"" supported by the sentence: ""Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.""?",False, +24999522,Sodium Chloride causes Nausea,1928,"In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.","Is the triple ""Sodium Chloride causes Nausea"" supported by the sentence: ""In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.""?",False, +23507574,Sodium Chloride causes burn,1929,"The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.","Is the triple ""Sodium Chloride causes burn"" supported by the sentence: ""The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.""?",False, +21365055,Sodium Chloride causes respiratory failure,1930,Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.,"Is the triple ""Sodium Chloride causes respiratory failure"" supported by the sentence: ""Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.""?",False, +20716492,Sodium Chloride causes multiple organ dysfunction syndrome,1931,"Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.","Is the triple ""Sodium Chloride causes multiple organ dysfunction syndrome"" supported by the sentence: ""Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.""?",False, +20666627,Sodium Chloride causes malaria,1932,"During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.","Is the triple ""Sodium Chloride causes malaria"" supported by the sentence: ""During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.""?",False, +20168868,Sodium Chloride causes fibromyalgia,1933,"Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.","Is the triple ""Sodium Chloride causes fibromyalgia"" supported by the sentence: ""Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.""?",False, +19652731,Sodium Chloride causes Chronic pain,1934,"METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.","Is the triple ""Sodium Chloride causes Chronic pain"" supported by the sentence: ""METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.""?",False, +19581650,Sodium Chloride causes neoplasm,1935,"NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.","Is the triple ""Sodium Chloride causes neoplasm"" supported by the sentence: ""NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.""?",False, +19527177,Sodium Chloride causes liver and intrahepatic bile duct neoplasm,1936,"Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.","Is the triple ""Sodium Chloride causes liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.""?",False, +19434783,Sodium Chloride causes Low back pain,1937,"METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).","Is the triple ""Sodium Chloride causes Low back pain"" supported by the sentence: ""METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).""?",False, +19352698,Sodium Chloride causes bone fracture,1938,"Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.","Is the triple ""Sodium Chloride causes bone fracture"" supported by the sentence: ""Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.""?",False, +19268574,Sodium Chloride causes ulcerative colitis,1939,"Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.","Is the triple ""Sodium Chloride causes ulcerative colitis"" supported by the sentence: ""Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.""?",False, +18873789,Sodium Chloride causes preeclampsia,1940,This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.,"Is the triple ""Sodium Chloride causes preeclampsia"" supported by the sentence: ""This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.""?",False, +18760766,Sodium Chloride causes heart disorder,1941,"Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.","Is the triple ""Sodium Chloride causes heart disorder"" supported by the sentence: ""Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.""?",False, +18419412,Sodium Chloride causes infertility disorder,1942,"The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.","Is the triple ""Sodium Chloride causes infertility disorder"" supported by the sentence: ""The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.""?",False, +18184755,Sodium Chloride causes intervertebral disc degenerative disorder,1943,"Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.","Is the triple ""Sodium Chloride causes intervertebral disc degenerative disorder"" supported by the sentence: ""Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.""?",False, +18174270,Sodium Chloride causes asthma,1944,"We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.","Is the triple ""Sodium Chloride causes asthma"" supported by the sentence: ""We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.""?",False, +17957169,Sodium Chloride causes subarachnoid hemorrhage,1945,Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.,"Is the triple ""Sodium Chloride causes subarachnoid hemorrhage"" supported by the sentence: ""Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.""?",False, +17846702,Sodium Chloride causes cardiovascular disorder,1946,"Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.","Is the triple ""Sodium Chloride causes cardiovascular disorder"" supported by the sentence: ""Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.""?",False, +17472790,Sodium Chloride causes Postoperative Complications,1947,"BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.","Is the triple ""Sodium Chloride causes Postoperative Complications"" supported by the sentence: ""BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.""?",False, +17050802,Sodium Chloride causes pulmonary arterial hypertension,1948,Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.,"Is the triple ""Sodium Chloride causes pulmonary arterial hypertension"" supported by the sentence: ""Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.""?",False, +16922792,Sodium Chloride causes aortic aneurysm,1949,"CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.","Is the triple ""Sodium Chloride causes aortic aneurysm"" supported by the sentence: ""CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.""?",False, +16902385,Sodium Chloride causes Hypoxemia,1950,The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.,"Is the triple ""Sodium Chloride causes Hypoxemia"" supported by the sentence: ""The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.""?",False, +16884655,Sodium Chloride causes obesity disorder,1951,[Promoting obesity with the salt shaker. How too much salt causes obesity in children].,"Is the triple ""Sodium Chloride causes obesity disorder"" supported by the sentence: ""[Promoting obesity with the salt shaker. How too much salt causes obesity in children].""?",False, +15862216,Sodium Chloride causes Sepsis,1952,"In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.","Is the triple ""Sodium Chloride causes Sepsis"" supported by the sentence: ""In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.""?",False, +15183436,Sodium Chloride causes cardiac rhythm disease,1953,"CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""","Is the triple ""Sodium Chloride causes cardiac rhythm disease"" supported by the sentence: ""CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""""?",False, +14507617,Sodium Chloride causes brain edema,1954,"The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.","Is the triple ""Sodium Chloride causes brain edema"" supported by the sentence: ""The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.""?",False, +14335740,Sodium Chloride causes essential hypertension,1955,"Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.","Is the triple ""Sodium Chloride causes essential hypertension"" supported by the sentence: ""Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.""?",False, +14100671,Sodium Chloride causes Cough,1956,"Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.","Is the triple ""Sodium Chloride causes Cough"" supported by the sentence: ""Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.""?",False, +13899816,Sodium Chloride causes brain injury,1957,BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.,"Is the triple ""Sodium Chloride causes brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.""?",False, +13415978,Sodium Chloride causes rhinitis,1958,Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).,"Is the triple ""Sodium Chloride causes rhinitis"" supported by the sentence: ""Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).""?",False, +13156241,Sodium Chloride causes allergic disease,1959,"The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.","Is the triple ""Sodium Chloride causes allergic disease"" supported by the sentence: ""The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.""?",False, +12922926,Sodium Chloride causes periodontitis,1960,"Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.","Is the triple ""Sodium Chloride causes periodontitis"" supported by the sentence: ""Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.""?",False, +12796728,Sodium Chloride causes myocardial infarction,1961,"Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.","Is the triple ""Sodium Chloride causes myocardial infarction"" supported by the sentence: ""Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.""?",False, +12757253,Sodium Chloride causes urticaria,1962,"If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.","Is the triple ""Sodium Chloride causes urticaria"" supported by the sentence: ""If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.""?",False, +12052924,Sodium Chloride causes Fever,1963,"Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.","Is the triple ""Sodium Chloride causes Fever"" supported by the sentence: ""Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.""?",False, +11367442,Sodium Chloride causes Hypothermia,1964,"In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.","Is the triple ""Sodium Chloride causes Hypothermia"" supported by the sentence: ""In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.""?",False, +10844905,Sodium Chloride causes kidney disorder,1965,These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.,"Is the triple ""Sodium Chloride causes kidney disorder"" supported by the sentence: ""These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.""?",False, +10703852,Sodium Chloride causes Ascites,1966,Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.,"Is the triple ""Sodium Chloride causes Ascites"" supported by the sentence: ""Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.""?",False, +10680402,Sodium Chloride causes kidney failure,1967,[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].,"Is the triple ""Sodium Chloride causes kidney failure"" supported by the sentence: ""[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].""?",False, +10468869,Sodium Chloride causes Hyperhidrosis,1968,The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.,"Is the triple ""Sodium Chloride causes Hyperhidrosis"" supported by the sentence: ""The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.""?",False, +10303736,Sodium Chloride causes Hemorrhage,1969,Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.,"Is the triple ""Sodium Chloride causes Hemorrhage"" supported by the sentence: ""Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.""?",False, +10216492,Sodium Chloride causes Insulin resistance,1970,"What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.","Is the triple ""Sodium Chloride causes Insulin resistance"" supported by the sentence: ""What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.""?",False, +9649854,Sodium Chloride causes Inflammation,1971,Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.,"Is the triple ""Sodium Chloride causes Inflammation"" supported by the sentence: ""Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.""?",False, +9417058,Sodium Chloride causes stroke disorder,1972,"The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.","Is the triple ""Sodium Chloride causes stroke disorder"" supported by the sentence: ""The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.""?",False, +9370401,Sodium Chloride causes acute kidney failure,1973,"RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.","Is the triple ""Sodium Chloride causes acute kidney failure"" supported by the sentence: ""RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.""?",False, +9311776,Sodium Chloride causes hypotensive disorder,1974,Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.,"Is the triple ""Sodium Chloride causes hypotensive disorder"" supported by the sentence: ""Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.""?",False, +8912328,Sodium Chloride causes injury,1975,"Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.","Is the triple ""Sodium Chloride causes injury"" supported by the sentence: ""Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.""?",False, +8760965,Sodium Chloride causes hyperinsulinism,1976,"Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).","Is the triple ""Sodium Chloride causes hyperinsulinism"" supported by the sentence: ""Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).""?",False, +8723767,Sodium Chloride causes Hyponatremia,1977,"The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.","Is the triple ""Sodium Chloride causes Hyponatremia"" supported by the sentence: ""The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.""?",False, +8658207,Sodium Chloride causes ischemic disease,1978,"Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.","Is the triple ""Sodium Chloride causes ischemic disease"" supported by the sentence: ""Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.""?",False, +8215909,Sodium Chloride causes type 2 diabetes mellitus,1979,"The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.","Is the triple ""Sodium Chloride causes type 2 diabetes mellitus"" supported by the sentence: ""The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.""?",False, +7966995,Sodium Chloride causes Shock,1980,"In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.","Is the triple ""Sodium Chloride causes Shock"" supported by the sentence: ""In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.""?",False, +7871886,Sodium Chloride causes Hypernatremia,1981,"Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').","Is the triple ""Sodium Chloride causes Hypernatremia"" supported by the sentence: ""Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').""?",False, +7769838,Sodium Chloride causes Pain,1982,The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.,"Is the triple ""Sodium Chloride causes Pain"" supported by the sentence: ""The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.""?",False, +7535626,Sodium Chloride causes pulmonary edema,1983,"The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.","Is the triple ""Sodium Chloride causes pulmonary edema"" supported by the sentence: ""The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.""?",False, +7170398,Sodium Chloride causes cataract,1984,"Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.","Is the triple ""Sodium Chloride causes cataract"" supported by the sentence: ""Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.""?",False, +7067270,Sodium Chloride causes hypertensive disorder,1985,"The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.","Is the triple ""Sodium Chloride causes hypertensive disorder"" supported by the sentence: ""The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.""?",False, +27640062,Sodium Chloride affects hyperinsulinism,1986,Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.,"Is the triple ""Sodium Chloride affects hyperinsulinism"" supported by the sentence: ""Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.""?",False, +27459630,Sodium Chloride affects ischemic disease,1987,"In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.","Is the triple ""Sodium Chloride affects ischemic disease"" supported by the sentence: ""In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.""?",False, +26883243,Sodium Chloride affects pulmonary edema,1988,"The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.","Is the triple ""Sodium Chloride affects pulmonary edema"" supported by the sentence: ""The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.""?",False, +25873721,Sodium Chloride affects stroke disorder,1989,Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].,"Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].""?",False, +25698961,Sodium Chloride affects Hypovolemia,1990,"However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.","Is the triple ""Sodium Chloride affects Hypovolemia"" supported by the sentence: ""However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.""?",False, +23350231,Sodium Chloride affects allergic disease,1991,"Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.""?",False, +21279163,Sodium Chloride affects Postoperative Nausea and Vomiting,1992,Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride affects Postoperative Nausea and Vomiting"" supported by the sentence: ""Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.""?",False, +19916489,Sodium Chloride affects malaria,1993,"The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.""?",False, +19654566,Sodium Chloride affects Fever,1994,The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.,"Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.""?",False, +19387644,Sodium Chloride affects Dyspnea,1995,The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.,"Is the triple ""Sodium Chloride affects Dyspnea"" supported by the sentence: ""The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.""?",False, +19198162,Sodium Chloride affects Hyperhidrosis,1996,"ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.""?",False, +19068195,Sodium Chloride affects Pain,1997,RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.,"Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.""?",False, +18857149,Sodium Chloride affects injury,1998,We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.""?",False, +18063112,Sodium Chloride affects myocardial infarction,1999,Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.,"Is the triple ""Sodium Chloride affects myocardial infarction"" supported by the sentence: ""Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.""?",False, +17981225,Sodium Chloride affects Fever,2000,"The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.""?",False, +17956116,Sodium Chloride affects Hyponatremia,2001,Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.,"Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.""?",False, +17749046,Sodium Chloride affects asthma,2002,The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.""?",False, +17453252,Sodium Chloride affects Hyperhidrosis,2003,"The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.""?",False, +17320603,Sodium Chloride affects brain injury,2004,"STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.""?",False, +17252322,Sodium Chloride affects iron deficiency anemia,2005,"At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.","Is the triple ""Sodium Chloride affects iron deficiency anemia"" supported by the sentence: ""At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.""?",False, +17081119,Sodium Chloride affects cataract,2006,PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride affects cataract"" supported by the sentence: ""PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.""?",False, +17021361,Sodium Chloride affects urticaria,2007,"CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.","Is the triple ""Sodium Chloride affects urticaria"" supported by the sentence: ""CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.""?",False, +16829226,Sodium Chloride affects osteoarthritis,2008,"The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.","Is the triple ""Sodium Chloride affects osteoarthritis"" supported by the sentence: ""The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.""?",False, +16392979,Sodium Chloride affects Sepsis,2009,Effects of hydrogen-rich saline treatment on polymicrobial sepsis.,"Is the triple ""Sodium Chloride affects Sepsis"" supported by the sentence: ""Effects of hydrogen-rich saline treatment on polymicrobial sepsis.""?",False, +16339812,Sodium Chloride affects Inflammation,2010,OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.,"Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.""?",False, +16191401,Sodium Chloride affects Shock,2011,"When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.","Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.""?",False, +16150899,Sodium Chloride affects severe cutaneous adverse reaction,2012,Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.,"Is the triple ""Sodium Chloride affects severe cutaneous adverse reaction"" supported by the sentence: ""Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.""?",False, +15784044,Sodium Chloride affects Electrolytes,2013,From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.,"Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.""?",False, +15684126,Sodium Chloride affects malaria,2014,"Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.""?",False, +15518572,Sodium Chloride affects ischemia reperfusion injury,2015,This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.,"Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.""?",False, +15358630,Sodium Chloride affects brain injury,2016,"Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.""?",False, +14974493,Sodium Chloride affects cardiovascular disorder,2017,"OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.","Is the triple ""Sodium Chloride affects cardiovascular disorder"" supported by the sentence: ""OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.""?",False, +14875621,Sodium Chloride affects Hypoxemia,2018,"CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.","Is the triple ""Sodium Chloride affects Hypoxemia"" supported by the sentence: ""CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.""?",False, +14652078,Sodium Chloride affects preeclampsia,2019,Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.,"Is the triple ""Sodium Chloride affects preeclampsia"" supported by the sentence: ""Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.""?",False, +14650670,Sodium Chloride affects Ascites,2020,In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.""?",False, +14454543,Sodium Chloride affects Inflammation,2021,"Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.","Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.""?",False, +14269847,Sodium Chloride affects kidney disorder,2022,"Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.","Is the triple ""Sodium Chloride affects kidney disorder"" supported by the sentence: ""Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.""?",False, +13713189,Sodium Chloride affects acute lung injury,2023,Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.,"Is the triple ""Sodium Chloride affects acute lung injury"" supported by the sentence: ""Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.""?",False, +13361928,Sodium Chloride affects cardiac rhythm disease,2024,"This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.","Is the triple ""Sodium Chloride affects cardiac rhythm disease"" supported by the sentence: ""This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.""?",False, +13091031,Sodium Chloride affects ischemia reperfusion injury,2025,"Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.","Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.""?",False, +12113298,Sodium Chloride affects diabetes mellitus,2026,"The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.","Is the triple ""Sodium Chloride affects diabetes mellitus"" supported by the sentence: ""The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.""?",False, +11936868,Sodium Chloride affects allergic disease,2027,"In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.""?",False, +11761266,Sodium Chloride affects stroke disorder,2028,"CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.","Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.""?",False, +11373059,Sodium Chloride affects Pain,2029,"In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.","Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.""?",False, +11352407,Sodium Chloride affects hypotensive disorder,2030,"Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.","Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.""?",False, +10762234,Sodium Chloride affects hypotensive disorder,2031,[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].,"Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].""?",False, +10689150,Sodium Chloride affects Hemorrhage,2032,"The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).""?",False, +10555492,Sodium Chloride affects nutritional disorder,2033,[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].,"Is the triple ""Sodium Chloride affects nutritional disorder"" supported by the sentence: ""[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].""?",False, +10543207,Sodium Chloride affects myocarditis,2034,"Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.","Is the triple ""Sodium Chloride affects myocarditis"" supported by the sentence: ""Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.""?",False, +10409590,Sodium Chloride affects essential hypertension,2035,"The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.","Is the triple ""Sodium Chloride affects essential hypertension"" supported by the sentence: ""The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.""?",False, +10373089,Sodium Chloride affects Hypernatremia,2036,"Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.","Is the triple ""Sodium Chloride affects Hypernatremia"" supported by the sentence: ""Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.""?",False, +10347664,Sodium Chloride affects neoplasm,2037,"However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.","Is the triple ""Sodium Chloride affects neoplasm"" supported by the sentence: ""However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.""?",False, +10303742,Sodium Chloride affects Hemorrhage,2038,"In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.""?",False, +10216887,Sodium Chloride affects Shock,2039,Refolding of a high molecular weight protein: salt effect on collapse.,"Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""Refolding of a high molecular weight protein: salt effect on collapse.""?",False, +10038950,Sodium Chloride affects injury,2040,This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.""?",False, +9833746,Sodium Chloride affects obesity disorder,2041,"Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.","Is the triple ""Sodium Chloride affects obesity disorder"" supported by the sentence: ""Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.""?",False, +9701968,Sodium Chloride affects brain edema,2042,The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.,"Is the triple ""Sodium Chloride affects brain edema"" supported by the sentence: ""The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.""?",False, +9235049,Sodium Chloride affects Hyponatremia,2043,"Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.","Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.""?",False, +9211629,Sodium Chloride affects asthma,2044,OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.""?",False, +8885675,Sodium Chloride affects Ascites,2045,The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.""?",False, +8142503,Sodium Chloride affects Insulin resistance,2046,"These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.","Is the triple ""Sodium Chloride affects Insulin resistance"" supported by the sentence: ""These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.""?",False, +7538296,Sodium Chloride affects depressive disorder,2047,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, +7487288,Sodium Chloride affects Hemorrhage,2048,Epinephrine in bupivacaine or saline reduced peroperative bleeding.,"Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""Epinephrine in bupivacaine or saline reduced peroperative bleeding.""?",False, +7249676,Sodium Chloride affects Fever,2049,"By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.""?",False, +7189372,Sodium Chloride affects depressive disorder,2050,"Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.""?",False, +7186849,Sodium Chloride affects hypertensive disorder,2051,"Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.","Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.""?",False, +7146026,Sodium Chloride affects hypertensive disorder,2052,This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.,"Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.""?",False, +10370500,Sodium Chloride affects Electrolytes,2053,"As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.","Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.""?",False, +14010559,Sodium Chloride produces hypertensive disorder,2054,Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.,"Is the triple ""Sodium Chloride produces hypertensive disorder"" supported by the sentence: ""Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.""?",False, +25864505,Sodium Chloride disrupts malaria,2055,A trial of chloroquine-medicated salt for malaria suppression in Uganda.,"Is the triple ""Sodium Chloride disrupts malaria"" supported by the sentence: ""A trial of chloroquine-medicated salt for malaria suppression in Uganda.""?",False, +19817939,Sodium Chloride disrupts chronic obstructive pulmonary disease,2056,Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.,"Is the triple ""Sodium Chloride disrupts chronic obstructive pulmonary disease"" supported by the sentence: ""Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.""?",False, +19569177,Sodium Chloride disrupts anxiety,2057,Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.,"Is the triple ""Sodium Chloride disrupts anxiety"" supported by the sentence: ""Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.""?",False, +19347835,Sodium Chloride disrupts cardiac rhythm disease,2058,Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.,"Is the triple ""Sodium Chloride disrupts cardiac rhythm disease"" supported by the sentence: ""Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.""?",False, +19339201,Sodium Chloride disrupts Cough,2059,"On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.","Is the triple ""Sodium Chloride disrupts Cough"" supported by the sentence: ""On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.""?",False, +18711875,Sodium Chloride disrupts pulmonary edema,2060,"Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.","Is the triple ""Sodium Chloride disrupts pulmonary edema"" supported by the sentence: ""Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.""?",False, +18638520,Sodium Chloride disrupts brain edema,2061,TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.,"Is the triple ""Sodium Chloride disrupts brain edema"" supported by the sentence: ""TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.""?",False, +18394970,Sodium Chloride disrupts Inflammation,2062,"In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.","Is the triple ""Sodium Chloride disrupts Inflammation"" supported by the sentence: ""In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.""?",False, +17319016,Sodium Chloride disrupts dental caries,2063,"Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.","Is the triple ""Sodium Chloride disrupts dental caries"" supported by the sentence: ""Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.""?",False, +17223012,Sodium Chloride disrupts hypertensive disorder,2064,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts hypertensive disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, +17223011,Sodium Chloride disrupts cardiovascular disorder,2065,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts cardiovascular disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, +17009512,Sodium Chloride disrupts allergic disease,2066,"Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.","Is the triple ""Sodium Chloride disrupts allergic disease"" supported by the sentence: ""Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.""?",False, +13585452,Sodium Chloride disrupts neoplasm,2067,"Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.","Is the triple ""Sodium Chloride disrupts neoplasm"" supported by the sentence: ""Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.""?",False, +12586414,Sodium Chloride disrupts Hypoxemia,2068,"Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.","Is the triple ""Sodium Chloride disrupts Hypoxemia"" supported by the sentence: ""Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.""?",False, +12214170,Sodium Chloride disrupts injury,2069,"Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.","Is the triple ""Sodium Chloride disrupts injury"" supported by the sentence: ""Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.""?",False, +10927798,Sodium Chloride disrupts stroke disorder,2070,"The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.","Is the triple ""Sodium Chloride disrupts stroke disorder"" supported by the sentence: ""The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.""?",False, +8273399,Sodium Chloride disrupts Pain,2071,Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.,"Is the triple ""Sodium Chloride disrupts Pain"" supported by the sentence: ""Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.""?",False, +27207716,Sodium Chloride prevents periodontal disorder,2072,"Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.","Is the triple ""Sodium Chloride prevents periodontal disorder"" supported by the sentence: ""Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.""?",False, +27075073,Sodium Chloride prevents subarachnoid hemorrhage,2073,"The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.","Is the triple ""Sodium Chloride prevents subarachnoid hemorrhage"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.""?",False, +23771600,Sodium Chloride prevents sinusitis,2074,Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.,"Is the triple ""Sodium Chloride prevents sinusitis"" supported by the sentence: ""Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.""?",False, +21279166,Sodium Chloride prevents Postoperative Nausea and Vomiting,2075,Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.""?",False, +20586429,Sodium Chloride prevents stroke disorder,2076,"In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).","Is the triple ""Sodium Chloride prevents stroke disorder"" supported by the sentence: ""In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).""?",False, +20472317,Sodium Chloride prevents myocardial infarction,2077,This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.,"Is the triple ""Sodium Chloride prevents myocardial infarction"" supported by the sentence: ""This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.""?",False, +20150308,Sodium Chloride prevents Chronic pain,2078,"Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.","Is the triple ""Sodium Chloride prevents Chronic pain"" supported by the sentence: ""Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.""?",False, +20050861,Sodium Chloride prevents Dyspnea,2079,DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.,"Is the triple ""Sodium Chloride prevents Dyspnea"" supported by the sentence: ""DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.""?",False, +19622277,Sodium Chloride prevents Pruritus,2080,"IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).","Is the triple ""Sodium Chloride prevents Pruritus"" supported by the sentence: ""IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).""?",False, +19347836,Sodium Chloride prevents cardiac rhythm disease,2081,"Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.","Is the triple ""Sodium Chloride prevents cardiac rhythm disease"" supported by the sentence: ""Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.""?",False, +18643598,Sodium Chloride prevents ventricular tachycardia,2082,"Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.","Is the triple ""Sodium Chloride prevents ventricular tachycardia"" supported by the sentence: ""Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.""?",False, +18145237,Sodium Chloride prevents Nausea,2083,The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).,"Is the triple ""Sodium Chloride prevents Nausea"" supported by the sentence: ""The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).""?",False, +17285701,Sodium Chloride prevents neuralgia,2084,"In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).","Is the triple ""Sodium Chloride prevents neuralgia"" supported by the sentence: ""In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).""?",False, +17081118,Sodium Chloride prevents cataract,2085,CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride prevents cataract"" supported by the sentence: ""CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.""?",False, +16603496,Sodium Chloride prevents brain injury,2086,DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.,"Is the triple ""Sodium Chloride prevents brain injury"" supported by the sentence: ""DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.""?",False, +16427621,Sodium Chloride prevents diabetes mellitus,2087,"Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.","Is the triple ""Sodium Chloride prevents diabetes mellitus"" supported by the sentence: ""Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.""?",False, +16310359,Sodium Chloride prevents burn,2088,CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.,"Is the triple ""Sodium Chloride prevents burn"" supported by the sentence: ""CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.""?",False, +16010295,Sodium Chloride prevents ischemic disease,2089,These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.,"Is the triple ""Sodium Chloride prevents ischemic disease"" supported by the sentence: ""These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.""?",False, +15507954,Sodium Chloride prevents pulmonary arterial hypertension,2090,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.","Is the triple ""Sodium Chloride prevents pulmonary arterial hypertension"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.""?",False, +15307837,Sodium Chloride prevents acute lung injury,2091,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.","Is the triple ""Sodium Chloride prevents acute lung injury"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.""?",False, +15219283,Sodium Chloride prevents allergic disease,2092,"KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.","Is the triple ""Sodium Chloride prevents allergic disease"" supported by the sentence: ""KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.""?",False, +14919203,Sodium Chloride prevents spinal cord injury,2093,Hydrogen-rich saline protects against spinal cord injury in rats.,"Is the triple ""Sodium Chloride prevents spinal cord injury"" supported by the sentence: ""Hydrogen-rich saline protects against spinal cord injury in rats.""?",False, +14359710,Sodium Chloride prevents obesity disorder,2094,"METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.","Is the triple ""Sodium Chloride prevents obesity disorder"" supported by the sentence: ""METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.""?",False, +14313516,Sodium Chloride prevents Inflammation,2095,"In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.","Is the triple ""Sodium Chloride prevents Inflammation"" supported by the sentence: ""In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.""?",False, +14313515,Sodium Chloride prevents ischemia reperfusion injury,2096,Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.,"Is the triple ""Sodium Chloride prevents ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.""?",False, +13297854,Sodium Chloride prevents kidney disorder,2097,"In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.","Is the triple ""Sodium Chloride prevents kidney disorder"" supported by the sentence: ""In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.""?",False, +12464836,Sodium Chloride prevents malaria,2098,"The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.","Is the triple ""Sodium Chloride prevents malaria"" supported by the sentence: ""The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.""?",False, +12453134,Sodium Chloride prevents iron deficiency anemia,2099,Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).,"Is the triple ""Sodium Chloride prevents iron deficiency anemia"" supported by the sentence: ""Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).""?",False, +12276610,Sodium Chloride prevents essential hypertension,2100,The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.,"Is the triple ""Sodium Chloride prevents essential hypertension"" supported by the sentence: ""The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.""?",False, +12092501,Sodium Chloride prevents hypertensive disorder,2101,"Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.","Is the triple ""Sodium Chloride prevents hypertensive disorder"" supported by the sentence: ""Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.""?",False, +11205687,Sodium Chloride prevents acute kidney failure,2102,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Chloride prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, +10429352,Sodium Chloride prevents injury,2103,"Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.","Is the triple ""Sodium Chloride prevents injury"" supported by the sentence: ""Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.""?",False, +10205494,Sodium Chloride prevents Hypovolemia,2104,"Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.","Is the triple ""Sodium Chloride prevents Hypovolemia"" supported by the sentence: ""Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.""?",False, +9628485,Sodium Chloride prevents anemia,2105,The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.,"Is the triple ""Sodium Chloride prevents anemia"" supported by the sentence: ""The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.""?",False, +8227059,Sodium Chloride prevents Shock,2106,The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.,"Is the triple ""Sodium Chloride prevents Shock"" supported by the sentence: ""The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.""?",False, +8196581,Sodium Chloride prevents dental caries,2107,Fluorinated salt was added to rations of preschool children for preventing dental caries.,"Is the triple ""Sodium Chloride prevents dental caries"" supported by the sentence: ""Fluorinated salt was added to rations of preschool children for preventing dental caries.""?",False, +8059428,Sodium Chloride prevents Pain,2108,"RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.","Is the triple ""Sodium Chloride prevents Pain"" supported by the sentence: ""RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.""?",False, +22103068,Sodium Chloride exacerbates hypertensive disorder,2109,The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.,"Is the triple ""Sodium Chloride exacerbates hypertensive disorder"" supported by the sentence: ""The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.""?",False, +20308305,Sodium Chloride exacerbates Inflammation,2110,"NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.","Is the triple ""Sodium Chloride exacerbates Inflammation"" supported by the sentence: ""NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.""?",False, +21816011,Sodium Chloride predisposes essential hypertension,2111,"This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.","Is the triple ""Sodium Chloride predisposes essential hypertension"" supported by the sentence: ""This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.""?",False, +19774957,Sodium Chloride predisposes pulmonary edema,2112,"Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.","Is the triple ""Sodium Chloride predisposes pulmonary edema"" supported by the sentence: ""Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.""?",False, +18380691,Sodium Chloride predisposes myocardial infarction,2113,"Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.","Is the triple ""Sodium Chloride predisposes myocardial infarction"" supported by the sentence: ""Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.""?",False, +18041213,Sodium Chloride predisposes Inflammation,2114,The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.,"Is the triple ""Sodium Chloride predisposes Inflammation"" supported by the sentence: ""The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.""?",False, +16033022,Sodium Chloride predisposes injury,2115,"In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.","Is the triple ""Sodium Chloride predisposes injury"" supported by the sentence: ""In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.""?",False, +13840593,Sodium Chloride predisposes allergic disease,2116,IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.,"Is the triple ""Sodium Chloride predisposes allergic disease"" supported by the sentence: ""IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.""?",False, +13808663,Sodium Chloride predisposes diabetes mellitus,2117,"Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.","Is the triple ""Sodium Chloride predisposes diabetes mellitus"" supported by the sentence: ""Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.""?",False, +13731023,Sodium Chloride predisposes cardiovascular disorder,2118,It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.,"Is the triple ""Sodium Chloride predisposes cardiovascular disorder"" supported by the sentence: ""It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.""?",False, +12280034,Sodium Chloride predisposes neoplasm,2119,"The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.","Is the triple ""Sodium Chloride predisposes neoplasm"" supported by the sentence: ""The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.""?",False, +12079247,Sodium Chloride predisposes hypertensive disorder,2120,"Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.","Is the triple ""Sodium Chloride predisposes hypertensive disorder"" supported by the sentence: ""Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.""?",False, +11776631,Sodium Chloride predisposes stroke disorder,2121,"These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.","Is the triple ""Sodium Chloride predisposes stroke disorder"" supported by the sentence: ""These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.""?",False, +11266800,Sodium Chloride predisposes kidney disorder,2122,"The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.","Is the triple ""Sodium Chloride predisposes kidney disorder"" supported by the sentence: ""The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.""?",False, +10118531,Sodium Chloride predisposes obesity disorder,2123,"To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).","Is the triple ""Sodium Chloride predisposes obesity disorder"" supported by the sentence: ""To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).""?",False, +9111875,Sodium Chloride predisposes cardiac rhythm disease,2124,"Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).","Is the triple ""Sodium Chloride predisposes cardiac rhythm disease"" supported by the sentence: ""Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).""?",False, +9647073,Dexpanthenol related to skin disorder,2125,Topical use of dexpanthenol in skin disorders.,"Is the triple ""Dexpanthenol related to skin disorder"" supported by the sentence: ""Topical use of dexpanthenol in skin disorders.""?",False, +26305399,Dexpanthenol affects Erythema,2126,"Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.","Is the triple ""Dexpanthenol affects Erythema"" supported by the sentence: ""Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.""?",False, +25421467,Dexpanthenol prevents cheilitis,2127,OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.,"Is the triple ""Dexpanthenol prevents cheilitis"" supported by the sentence: ""OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.""?",False, +24024712,ELTROMBOPAG related to autoimmune thrombocytopenic purpura,2128,"CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.","Is the triple ""ELTROMBOPAG related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.""?",False, +22097814,ELTROMBOPAG related to acute myeloid leukemia,2129,A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.,"Is the triple ""ELTROMBOPAG related to acute myeloid leukemia"" supported by the sentence: ""A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.""?",False, +22063304,ELTROMBOPAG related to aplastic anemia,2130,The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.,"Is the triple ""ELTROMBOPAG related to aplastic anemia"" supported by the sentence: ""The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.""?",False, +22063303,ELTROMBOPAG related to myelodysplastic syndrome,2131,We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.,"Is the triple ""ELTROMBOPAG related to myelodysplastic syndrome"" supported by the sentence: ""We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.""?",False, +22049758,ELTROMBOPAG related to thrombocytopenia,2132,"Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.","Is the triple ""ELTROMBOPAG related to thrombocytopenia"" supported by the sentence: ""Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.""?",False, +23835836,ELTROMBOPAG causes anemia,2133,This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.,"Is the triple ""ELTROMBOPAG causes anemia"" supported by the sentence: ""This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.""?",False, +22601227,ELTROMBOPAG affects thrombocytopenia,2134,The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.""?",False, +21709185,ELTROMBOPAG affects thrombocytopenia,2135,We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.""?",False, +22821304,ELTROMBOPAG prevents Hemorrhage,2136,"Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.","Is the triple ""ELTROMBOPAG prevents Hemorrhage"" supported by the sentence: ""Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.""?",False, +22169266,ELTROMBOPAG prevents thrombocytopenia,2137,We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.,"Is the triple ""ELTROMBOPAG prevents thrombocytopenia"" supported by the sentence: ""We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.""?",False, +12546229,Etamsylate affects Hemorrhage,2138,"Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.","Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.""?",False, +9791897,Etamsylate affects Hemorrhage,2139,Effect of Etamsylate on menstrual blood loss in women using IUDs.,"Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Effect of Etamsylate on menstrual blood loss in women using IUDs.""?",False, +22608563,Etamsylate prevents Hemorrhage,2140,Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.,"Is the triple ""Etamsylate prevents Hemorrhage"" supported by the sentence: ""Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.""?",False, +26536250,mitomycin C related to Deoxyribonucleic acid,2141,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, +26536250,mitomycin C related to Deoxyribonucleic acid,2142,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, +26158944,mitomycin C related to adenocarcinoma,2143,"Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.","Is the triple ""mitomycin C related to adenocarcinoma"" supported by the sentence: ""Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.""?",False, +26111339,mitomycin C related to squamous cell carcinoma,2144,"Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.","Is the triple ""mitomycin C related to squamous cell carcinoma"" supported by the sentence: ""Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.""?",False, +26043076,mitomycin C related to neoplasm,2145,"The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.","Is the triple ""mitomycin C related to neoplasm"" supported by the sentence: ""The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.""?",False, +25722815,mitomycin C related to leukemia,2146,"Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.","Is the triple ""mitomycin C related to leukemia"" supported by the sentence: ""Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.""?",False, +12722759,mitomycin C related to carcinoma,2147,"Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.","Is the triple ""mitomycin C related to carcinoma"" supported by the sentence: ""Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.""?",False, +10467532,mitomycin C related to non-small cell lung carcinoma,2148,"A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.","Is the triple ""mitomycin C related to non-small cell lung carcinoma"" supported by the sentence: ""A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.""?",False, +7255625,mitomycin C related to Deoxyribonucleic acid,2149,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, +7255625,mitomycin C related to Deoxyribonucleic acid,2150,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, +8689799,mitomycin C coexists with Deoxyribonucleic acid,2151,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, +8689799,mitomycin C coexists with Deoxyribonucleic acid,2152,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, +8030161,mitomycin C coexists with Deoxyribonucleic acid,2153,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, +8030161,mitomycin C coexists with Deoxyribonucleic acid,2154,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, +7255626,mitomycin C physically interacts with Deoxyribonucleic acid,2155,"Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.","Is the triple ""mitomycin C physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.""?",False, +25769130,mitomycin C causes sarcoma,2156,"Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.","Is the triple ""mitomycin C causes sarcoma"" supported by the sentence: ""Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.""?",False, +25692678,mitomycin C causes hepatocellular carcinoma,2157,The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.,"Is the triple ""mitomycin C causes hepatocellular carcinoma"" supported by the sentence: ""The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.""?",False, +20975852,mitomycin C causes carcinoma,2158,CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.,"Is the triple ""mitomycin C causes carcinoma"" supported by the sentence: ""CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.""?",False, +12184177,mitomycin C causes Corneal opacity,2159,"When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.","Is the triple ""mitomycin C causes Corneal opacity"" supported by the sentence: ""When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.""?",False, +11626710,mitomycin C causes urethral stricture,2160,Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.,"Is the triple ""mitomycin C causes urethral stricture"" supported by the sentence: ""Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.""?",False, +9485346,mitomycin C causes neoplasm,2161,The influence of mitomycin C on the induction of crown-gall tumors.,"Is the triple ""mitomycin C causes neoplasm"" supported by the sentence: ""The influence of mitomycin C on the induction of crown-gall tumors.""?",False, +26017044,mitomycin C affects squamous cell carcinoma,2162,Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.,"Is the triple ""mitomycin C affects squamous cell carcinoma"" supported by the sentence: ""Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.""?",False, +25924198,mitomycin C affects adenocarcinoma,2163,Effect of mitomycin-C on McCall rat colon adenocarcinoma.,"Is the triple ""mitomycin C affects adenocarcinoma"" supported by the sentence: ""Effect of mitomycin-C on McCall rat colon adenocarcinoma.""?",False, +24961205,mitomycin C affects neoplasm,2164,"CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.""?",False, +21183193,mitomycin C affects transitional cell carcinoma,2165,Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.,"Is the triple ""mitomycin C affects transitional cell carcinoma"" supported by the sentence: ""Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.""?",False, +20995393,mitomycin C affects urinary bladder neoplasm,2166,"Instillation of MMC markedly increased the development of bladder tumors, although CA did not.","Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""Instillation of MMC markedly increased the development of bladder tumors, although CA did not.""?",False, +20865956,mitomycin C affects pterygium,2167,Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.,"Is the triple ""mitomycin C affects pterygium"" supported by the sentence: ""Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.""?",False, +17166086,mitomycin C affects mesothelioma,2168,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""mitomycin C affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, +15342296,mitomycin C affects sclerosing cholangitis,2169,Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.,"Is the triple ""mitomycin C affects sclerosing cholangitis"" supported by the sentence: ""Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.""?",False, +14897135,mitomycin C affects Corneal opacity,2170,PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.,"Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.""?",False, +14480408,mitomycin C affects liver and intrahepatic bile duct neoplasm,2171,"The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.","Is the triple ""mitomycin C affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.""?",False, +14435862,mitomycin C affects Corneal opacity,2172,"Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.","Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.""?",False, +10146530,mitomycin C affects open-angle glaucoma,2173,A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.,"Is the triple ""mitomycin C affects open-angle glaucoma"" supported by the sentence: ""A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.""?",False, +8885108,mitomycin C affects urinary bladder neoplasm,2174,These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.,"Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.""?",False, +8612675,mitomycin C affects Deoxyribonucleic acid,2175,It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.,"Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.""?",False, +8242643,mitomycin C affects neoplasm,2176,"CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.""?",False, +8428809,mitomycin C affects Deoxyribonucleic acid,2177,"DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.","Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.""?",False, +26926271,mitomycin C disrupts Neoplasm Metastasis,2178,"When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.","Is the triple ""mitomycin C disrupts Neoplasm Metastasis"" supported by the sentence: ""When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.""?",False, +21172443,mitomycin C disrupts urinary bladder neoplasm,2179,"However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.","Is the triple ""mitomycin C disrupts urinary bladder neoplasm"" supported by the sentence: ""However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.""?",False, +16608751,mitomycin C disrupts carcinoma,2180,RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.,"Is the triple ""mitomycin C disrupts carcinoma"" supported by the sentence: ""RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.""?",False, +12093037,mitomycin C disrupts neoplasm,2181,"As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.","Is the triple ""mitomycin C disrupts neoplasm"" supported by the sentence: ""As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.""?",False, +8920186,mitomycin C disrupts Corneal opacity,2182,CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.,"Is the triple ""mitomycin C disrupts Corneal opacity"" supported by the sentence: ""CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.""?",False, +22973529,mitomycin C prevents glaucoma,2183,"CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.","Is the triple ""mitomycin C prevents glaucoma"" supported by the sentence: ""CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.""?",False, +19902018,mitomycin C prevents keratoconus,2184,Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.,"Is the triple ""mitomycin C prevents keratoconus"" supported by the sentence: ""Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.""?",False, +19673685,mitomycin C prevents urethral stricture,2185,Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.,"Is the triple ""mitomycin C prevents urethral stricture"" supported by the sentence: ""Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.""?",False, +12959208,mitomycin C prevents Neoplasm Metastasis,2186,"Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.","Is the triple ""mitomycin C prevents Neoplasm Metastasis"" supported by the sentence: ""Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.""?",False, +11642092,mitomycin C prevents Esophageal stenosis,2187,"The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.","Is the triple ""mitomycin C prevents Esophageal stenosis"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.""?",False, +9925117,mitomycin C prevents neoplasm,2188,"An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).","Is the triple ""mitomycin C prevents neoplasm"" supported by the sentence: ""An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).""?",False, +8410588,mitomycin C prevents pterygium,2189,"CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.","Is the triple ""mitomycin C prevents pterygium"" supported by the sentence: ""CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.""?",False, +7308263,mitomycin C prevents urinary bladder neoplasm,2190,"CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.","Is the triple ""mitomycin C prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.""?",False, +20886584,mitomycin C predisposes neoplasm,2191,These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.,"Is the triple ""mitomycin C predisposes neoplasm"" supported by the sentence: ""These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.""?",False, +17638153,Cefazolin related to bone fracture,2192,"The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.","Is the triple ""Cefazolin related to bone fracture"" supported by the sentence: ""The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.""?",False, +20958121,Cefazolin causes bacterial infectious disease with sepsis,2193,BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.,"Is the triple ""Cefazolin causes bacterial infectious disease with sepsis"" supported by the sentence: ""BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.""?",False, +25339548,Cefazolin affects obesity disorder,2194,"Overall, cefazolin pharmacokinetics are substantially altered in obesity.","Is the triple ""Cefazolin affects obesity disorder"" supported by the sentence: ""Overall, cefazolin pharmacokinetics are substantially altered in obesity.""?",False, +27670629,Cefazolin prevents staphylococcal infection,2195,PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.,"Is the triple ""Cefazolin prevents staphylococcal infection"" supported by the sentence: ""PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.""?",False, +10537097,Cefazolin prevents bacterial infectious disease,2196,"The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.","Is the triple ""Cefazolin prevents bacterial infectious disease"" supported by the sentence: ""The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.""?",False, +7415834,Famciclovir affects herpes zoster,2197,"However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.","Is the triple ""Famciclovir affects herpes zoster"" supported by the sentence: ""However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.""?",False, +27310156,Famciclovir disrupts viral infectious disease,2198,Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.,"Is the triple ""Famciclovir disrupts viral infectious disease"" supported by the sentence: ""Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.""?",False, +11859744,Famciclovir disrupts herpes simplex infectious disease,2199,OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.,"Is the triple ""Famciclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.""?",False, +11859743,Famciclovir disrupts genital herpes,2200,Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.,"Is the triple ""Famciclovir disrupts genital herpes"" supported by the sentence: ""Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.""?",False, +7415831,Famciclovir prevents herpes zoster,2201,"In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.","Is the triple ""Famciclovir prevents herpes zoster"" supported by the sentence: ""In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.""?",False, +27248580,Acyclovir related to herpes zoster,2202,Effect of acyclovir and prednisolone on the serological response in herpes zoster.,"Is the triple ""Acyclovir related to herpes zoster"" supported by the sentence: ""Effect of acyclovir and prednisolone on the serological response in herpes zoster.""?",False, +20916830,Acyclovir causes viral infectious disease,2203,"Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.","Is the triple ""Acyclovir causes viral infectious disease"" supported by the sentence: ""Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.""?",False, +21459205,Acyclovir affects herpes zoster,2204,"Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.","Is the triple ""Acyclovir affects herpes zoster"" supported by the sentence: ""Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.""?",False, +17108497,Acyclovir affects genital herpes,2205,In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.,"Is the triple ""Acyclovir affects genital herpes"" supported by the sentence: ""In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.""?",False, +15677184,Acyclovir affects viral infectious disease,2206,The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.,"Is the triple ""Acyclovir affects viral infectious disease"" supported by the sentence: ""The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.""?",False, +9966648,Acyclovir affects chickenpox,2207,2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.,"Is the triple ""Acyclovir affects chickenpox"" supported by the sentence: ""2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.""?",False, +8137898,Acyclovir affects cytomegalovirus infection,2208,"In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.","Is the triple ""Acyclovir affects cytomegalovirus infection"" supported by the sentence: ""In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.""?",False, +26100053,Acyclovir disrupts herpes zoster,2209,"When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.","Is the triple ""Acyclovir disrupts herpes zoster"" supported by the sentence: ""When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.""?",False, +21196251,Acyclovir disrupts cytomegalovirus infection,2210,"METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.","Is the triple ""Acyclovir disrupts cytomegalovirus infection"" supported by the sentence: ""METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.""?",False, +21045605,Acyclovir disrupts herpes simplex infectious disease,2211,Bortezomib and acyclovir acted synergistically to inhibit HSV infection.,"Is the triple ""Acyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Bortezomib and acyclovir acted synergistically to inhibit HSV infection.""?",False, +13979845,Acyclovir disrupts HIV infectious disease,2212,"In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.","Is the triple ""Acyclovir disrupts HIV infectious disease"" supported by the sentence: ""In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.""?",False, +11163493,Acyclovir disrupts chickenpox,2213,BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.,"Is the triple ""Acyclovir disrupts chickenpox"" supported by the sentence: ""BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.""?",False, +10081763,Acyclovir disrupts viral infectious disease,2214,"Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.","Is the triple ""Acyclovir disrupts viral infectious disease"" supported by the sentence: ""Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.""?",False, +8112053,Acyclovir disrupts genital herpes,2215,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Acyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, +22220716,Acyclovir prevents chickenpox,2216,Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.,"Is the triple ""Acyclovir prevents chickenpox"" supported by the sentence: ""Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.""?",False, +14453930,Acyclovir prevents herpes zoster,2217,Continuous administration of ACV decreased the incidence of HZ infection.,"Is the triple ""Acyclovir prevents herpes zoster"" supported by the sentence: ""Continuous administration of ACV decreased the incidence of HZ infection.""?",False, +11048138,Acyclovir prevents herpes labialis,2218,The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.,"Is the triple ""Acyclovir prevents herpes labialis"" supported by the sentence: ""The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.""?",False, +10652424,Acyclovir prevents viral infectious disease,2219,The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.,"Is the triple ""Acyclovir prevents viral infectious disease"" supported by the sentence: ""The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.""?",False, +9977810,Acyclovir prevents genital herpes,2220,CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.,"Is the triple ""Acyclovir prevents genital herpes"" supported by the sentence: ""CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.""?",False, +8973083,Acyclovir prevents cytomegalovirus infection,2221,The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.,"Is the triple ""Acyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.""?",False, +8455850,Acyclovir prevents herpes simplex infectious disease,2222,"HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.","Is the triple ""Acyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.""?",False, +16777411,Acyclovir predisposes herpes simplex infectious disease,2223,"CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.","Is the triple ""Acyclovir predisposes herpes simplex infectious disease"" supported by the sentence: ""CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.""?",False, +14602481,Acyclovir predisposes HIV infectious disease,2224,We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.,"Is the triple ""Acyclovir predisposes HIV infectious disease"" supported by the sentence: ""We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.""?",False, +7066348,Idoxuridine coexists with Deoxyribonucleic acid,2225,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, +7066348,Idoxuridine coexists with Deoxyribonucleic acid,2226,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, +10786366,Idoxuridine coexists with Deoxyribonucleic acid,2227,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, +10786366,Idoxuridine coexists with Deoxyribonucleic acid,2228,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, +15969143,Idoxuridine derives from Deoxyribonucleic acid,2229,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, +15969143,Idoxuridine derives from Deoxyribonucleic acid,2230,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, +10765452,Idoxuridine physically interacts with Deoxyribonucleic acid,2231,Role of MutSalpha in the recognition of iododeoxyuridine in DNA.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Role of MutSalpha in the recognition of iododeoxyuridine in DNA.""?",False, +8193345,Idoxuridine physically interacts with Deoxyribonucleic acid,2232,The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.""?",False, +13332148,Idoxuridine causes viral infectious disease,2233,"Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.","Is the triple ""Idoxuridine causes viral infectious disease"" supported by the sentence: ""Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.""?",False, +25762983,Idoxuridine affects viral infectious disease,2234,Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.,"Is the triple ""Idoxuridine affects viral infectious disease"" supported by the sentence: ""Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.""?",False, +25024576,Idoxuridine affects Deoxyribonucleic acid,2235,"Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.","Is the triple ""Idoxuridine affects Deoxyribonucleic acid"" supported by the sentence: ""Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.""?",False, +25798138,Vidarabine affects herpes simplex infectious disease,2236,Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.,"Is the triple ""Vidarabine affects herpes simplex infectious disease"" supported by the sentence: ""Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.""?",False, +18005400,Ganciclovir related to AIDS,2237,[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].,"Is the triple ""Ganciclovir related to AIDS"" supported by the sentence: ""[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].""?",False, +11769089,Ganciclovir related to lymphoma,2238,Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.,"Is the triple ""Ganciclovir related to lymphoma"" supported by the sentence: ""Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.""?",False, +7813894,Ganciclovir causes hepatocellular carcinoma,2239,"However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.","Is the triple ""Ganciclovir causes hepatocellular carcinoma"" supported by the sentence: ""However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.""?",False, +21315977,Ganciclovir affects melanoma,2240,"In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.","Is the triple ""Ganciclovir affects melanoma"" supported by the sentence: ""In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.""?",False, +18696617,Ganciclovir affects viral infectious disease,2241,"It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.","Is the triple ""Ganciclovir affects viral infectious disease"" supported by the sentence: ""It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.""?",False, +14018850,Ganciclovir affects graft versus host disease,2242,OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).,"Is the triple ""Ganciclovir affects graft versus host disease"" supported by the sentence: ""OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).""?",False, +7745805,Ganciclovir affects hepatocellular carcinoma,2243,"Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.","Is the triple ""Ganciclovir affects hepatocellular carcinoma"" supported by the sentence: ""Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.""?",False, +7264703,Ganciclovir affects retinitis,2244,"CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.","Is the triple ""Ganciclovir affects retinitis"" supported by the sentence: ""CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.""?",False, +7193112,Ganciclovir affects cytomegalovirus retinitis,2245,"Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.","Is the triple ""Ganciclovir affects cytomegalovirus retinitis"" supported by the sentence: ""Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.""?",False, +27515973,Ganciclovir disrupts viral infectious disease,2246,"Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.","Is the triple ""Ganciclovir disrupts viral infectious disease"" supported by the sentence: ""Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.""?",False, +20042666,Ganciclovir disrupts glioblastoma,2247,"Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.","Is the triple ""Ganciclovir disrupts glioblastoma"" supported by the sentence: ""Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.""?",False, +11829393,Ganciclovir disrupts cytomegalovirus infection,2248,CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.,"Is the triple ""Ganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.""?",False, +9242712,Ganciclovir disrupts hepatocellular carcinoma,2249,Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.,"Is the triple ""Ganciclovir disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.""?",False, +27273103,Ganciclovir prevents retinitis,2250,"TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.","Is the triple ""Ganciclovir prevents retinitis"" supported by the sentence: ""TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.""?",False, +14947813,Ganciclovir prevents viral infectious disease,2251,"This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.","Is the triple ""Ganciclovir prevents viral infectious disease"" supported by the sentence: ""This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.""?",False, +8898867,Ganciclovir prevents cytomegalovirus retinitis,2252,"Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.","Is the triple ""Ganciclovir prevents cytomegalovirus retinitis"" supported by the sentence: ""Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.""?",False, +7606615,Ganciclovir prevents cytomegalovirus infection,2253,"Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.","Is the triple ""Ganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.""?",False, +26756507,Nedocromil affects asthma,2254,"As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.","Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.""?",False, +12807968,Nedocromil affects asthma,2255,AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.,"Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.""?",False, +15773495,Nedocromil disrupts asthma,2256,Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.,"Is the triple ""Nedocromil disrupts asthma"" supported by the sentence: ""Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.""?",False, +26602335,Nedocromil prevents asthma,2257,Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.,"Is the triple ""Nedocromil prevents asthma"" supported by the sentence: ""Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.""?",False, +25857910,Flumedroxone related to migraine disorder,2258,"A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.","Is the triple ""Flumedroxone related to migraine disorder"" supported by the sentence: ""A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.""?",False, +26456255,Valrubicin coexists with Deoxyribonucleic acid,2259,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, +26456255,Valrubicin coexists with Deoxyribonucleic acid,2260,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, +26331358,Valrubicin affects Deoxyribonucleic acid,2261,The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.,"Is the triple ""Valrubicin affects Deoxyribonucleic acid"" supported by the sentence: ""The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.""?",False, +9013591,Valrubicin affects neoplasm,2262,OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).,"Is the triple ""Valrubicin affects neoplasm"" supported by the sentence: ""OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).""?",False, +15048973,Valrubicin disrupts neoplasm,2263,Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.,"Is the triple ""Valrubicin disrupts neoplasm"" supported by the sentence: ""Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.""?",False, +19780799,"Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive",2264,"BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.","Is the triple ""Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.""?",False, +19123529,Idarubicin related to acute lymphoblastic leukemia,2265,"A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.","Is the triple ""Idarubicin related to acute lymphoblastic leukemia"" supported by the sentence: ""A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.""?",False, +17160344,Idarubicin related to myelodysplastic syndrome,2266,"Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.","Is the triple ""Idarubicin related to myelodysplastic syndrome"" supported by the sentence: ""Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.""?",False, +13481436,Idarubicin related to acute myeloid leukemia,2267,Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).,"Is the triple ""Idarubicin related to acute myeloid leukemia"" supported by the sentence: ""Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).""?",False, +12261572,Idarubicin related to plasma cell myeloma,2268,"High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.","Is the triple ""Idarubicin related to plasma cell myeloma"" supported by the sentence: ""High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.""?",False, +10347974,Idarubicin related to non-Hodgkin lymphoma,2269,"Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.","Is the triple ""Idarubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.""?",False, +8798925,Idarubicin related to acute promyelocytic leukemia,2270,Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.,"Is the triple ""Idarubicin related to acute promyelocytic leukemia"" supported by the sentence: ""Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.""?",False, +17955637,Idarubicin causes acute myeloid leukemia,2271,"On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.","Is the triple ""Idarubicin causes acute myeloid leukemia"" supported by the sentence: ""On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.""?",False, +10037923,Idarubicin causes neutropenia,2272,The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.,"Is the triple ""Idarubicin causes neutropenia"" supported by the sentence: ""The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.""?",False, +27637811,Idarubicin affects acute myeloid leukemia,2273,"In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.""?",False, +27582612,Idarubicin affects acute lymphoblastic leukemia,2274,The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.,"Is the triple ""Idarubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.""?",False, +27363552,Idarubicin affects neoplasm,2275,"However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.""?",False, +10133635,Idarubicin affects acute myeloid leukemia,2276,"Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.""?",False, +9755321,Idarubicin affects leukemia,2277,"We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.","Is the triple ""Idarubicin affects leukemia"" supported by the sentence: ""We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.""?",False, +9560678,Idarubicin affects neoplasm,2278,"Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.""?",False, +9242996,Idarubicin affects neutropenia,2279,These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.,"Is the triple ""Idarubicin affects neutropenia"" supported by the sentence: ""These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.""?",False, +18342294,Pirarubicin causes neoplasm,2280,RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.,"Is the triple ""Pirarubicin causes neoplasm"" supported by the sentence: ""RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.""?",False, +16182034,Pirarubicin affects neoplasm,2281,Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.,"Is the triple ""Pirarubicin affects neoplasm"" supported by the sentence: ""Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.""?",False, +19153993,Pirarubicin disrupts neoplasm,2282,"As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.","Is the triple ""Pirarubicin disrupts neoplasm"" supported by the sentence: ""As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.""?",False, +14778803,Pirarubicin prevents neoplasm,2283,"Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.","Is the triple ""Pirarubicin prevents neoplasm"" supported by the sentence: ""Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.""?",False, +20218174,Mitoxantrone subclass of Mitoxantrone dicarboxylic acid,2284,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone subclass of Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, +25737166,Mitoxantrone related to lymphoma,2285,"Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.","Is the triple ""Mitoxantrone related to lymphoma"" supported by the sentence: ""Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.""?",False, +19961419,Mitoxantrone related to breast neoplasm,2286,Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.,"Is the triple ""Mitoxantrone related to breast neoplasm"" supported by the sentence: ""Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.""?",False, +14217137,Mitoxantrone related to mantle cell lymphoma,2287,Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.,"Is the triple ""Mitoxantrone related to mantle cell lymphoma"" supported by the sentence: ""Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.""?",False, +13051364,Mitoxantrone related to multiple sclerosis,2288,"Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.","Is the triple ""Mitoxantrone related to multiple sclerosis"" supported by the sentence: ""Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.""?",False, +8903075,Mitoxantrone related to acute myeloid leukemia,2289,"Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.","Is the triple ""Mitoxantrone related to acute myeloid leukemia"" supported by the sentence: ""Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.""?",False, +8584278,Mitoxantrone causes acute myeloid leukemia,2290,"CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.","Is the triple ""Mitoxantrone causes acute myeloid leukemia"" supported by the sentence: ""CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.""?",False, +26143277,Mitoxantrone affects lymphoma,2291,"Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.","Is the triple ""Mitoxantrone affects lymphoma"" supported by the sentence: ""Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.""?",False, +20218175,Mitoxantrone affects Mitoxantrone dicarboxylic acid,2292,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone affects Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, +11986455,Mitoxantrone affects multiple sclerosis,2293,Therapeutic role of mitoxantrone in multiple sclerosis.,"Is the triple ""Mitoxantrone affects multiple sclerosis"" supported by the sentence: ""Therapeutic role of mitoxantrone in multiple sclerosis.""?",False, +9134230,Mitoxantrone prevents neoplasm,2294,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Mitoxantrone prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, +11307631,Mitoxantrone exacerbates multiple sclerosis,2295,Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.,"Is the triple ""Mitoxantrone exacerbates multiple sclerosis"" supported by the sentence: ""Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.""?",False, +26844498,Doxorubicin related to renal cell carcinoma,2296,Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.,"Is the triple ""Doxorubicin related to renal cell carcinoma"" supported by the sentence: ""Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.""?",False, +26506763,Doxorubicin related to Kaposi's sarcoma,2297,"The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.","Is the triple ""Doxorubicin related to Kaposi's sarcoma"" supported by the sentence: ""The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.""?",False, +26097255,Doxorubicin related to hepatocellular carcinoma,2298,The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.,"Is the triple ""Doxorubicin related to hepatocellular carcinoma"" supported by the sentence: ""The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.""?",False, +25468576,Doxorubicin related to non-Hodgkin lymphoma,2299,"OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.","Is the triple ""Doxorubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.""?",False, +21586070,Doxorubicin related to diffuse large B-cell lymphoma,2300,"Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.","Is the triple ""Doxorubicin related to diffuse large B-cell lymphoma"" supported by the sentence: ""Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.""?",False, +17293414,Doxorubicin related to neoplasm,2301,"Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.","Is the triple ""Doxorubicin related to neoplasm"" supported by the sentence: ""Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.""?",False, +14824461,Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma,2302,"A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.","Is the triple ""Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.""?",False, +12975330,"Doxorubicin related to Lymphoma, AIDS-Related",2303,"BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.","Is the triple ""Doxorubicin related to Lymphoma, AIDS-Related"" supported by the sentence: ""BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.""?",False, +12635005,Doxorubicin related to neuroendocrine neoplasm,2304,"Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.","Is the triple ""Doxorubicin related to neuroendocrine neoplasm"" supported by the sentence: ""Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.""?",False, +11664648,Doxorubicin related to non-small cell lung carcinoma,2305,"Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.","Is the triple ""Doxorubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.""?",False, +8248824,Doxorubicin related to lymphoma,2306,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Doxorubicin related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, +7897058,Doxorubicin related to leukemia,2307,Combined effect of lipoic acid and doxorubicin in murine leukemia.,"Is the triple ""Doxorubicin related to leukemia"" supported by the sentence: ""Combined effect of lipoic acid and doxorubicin in murine leukemia.""?",False, +7111309,Doxorubicin related to Hodgkins lymphoma,2308,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Doxorubicin related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, +26198671,Doxorubicin causes acute myeloid leukemia,2309,"Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.","Is the triple ""Doxorubicin causes acute myeloid leukemia"" supported by the sentence: ""Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.""?",False, +20905498,Doxorubicin causes prostate cancer,2310,"In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.","Is the triple ""Doxorubicin causes prostate cancer"" supported by the sentence: ""In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.""?",False, +19998968,Doxorubicin causes Hodgkins lymphoma,2311,"Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.","Is the triple ""Doxorubicin causes Hodgkins lymphoma"" supported by the sentence: ""Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.""?",False, +17176693,Doxorubicin causes B-cell neoplasm,2312,"Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.","Is the triple ""Doxorubicin causes B-cell neoplasm"" supported by the sentence: ""Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.""?",False, +16306119,Doxorubicin causes hepatocellular carcinoma,2313,"In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.","Is the triple ""Doxorubicin causes hepatocellular carcinoma"" supported by the sentence: ""In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.""?",False, +14936910,Doxorubicin causes plasma cell myeloma,2314,"Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.","Is the triple ""Doxorubicin causes plasma cell myeloma"" supported by the sentence: ""Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.""?",False, +13613509,Doxorubicin causes sarcoma,2315,Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.,"Is the triple ""Doxorubicin causes sarcoma"" supported by the sentence: ""Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.""?",False, +12176485,"Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive",2316,"Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.","Is the triple ""Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.""?",False, +12086573,Doxorubicin causes leukemia,2317,"We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.","Is the triple ""Doxorubicin causes leukemia"" supported by the sentence: ""We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.""?",False, +11480674,Doxorubicin causes Neoplasm Metastasis,2318,"The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.","Is the triple ""Doxorubicin causes Neoplasm Metastasis"" supported by the sentence: ""The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.""?",False, +11088747,Doxorubicin causes neoplasm,2319,"Furthermore, doxorubicin is known to induce tumor resistance genes.","Is the triple ""Doxorubicin causes neoplasm"" supported by the sentence: ""Furthermore, doxorubicin is known to induce tumor resistance genes.""?",False, +7374660,Doxorubicin causes neutropenia,2320,"Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.","Is the triple ""Doxorubicin causes neutropenia"" supported by the sentence: ""Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.""?",False, +25410483,Doxorubicin affects glioma,2321,"By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.","Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.""?",False, +25202161,Doxorubicin affects glioblastoma,2322,The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.,"Is the triple ""Doxorubicin affects glioblastoma"" supported by the sentence: ""The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.""?",False, +24066270,Doxorubicin affects triple-negative breast carcinoma,2323,Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.,"Is the triple ""Doxorubicin affects triple-negative breast carcinoma"" supported by the sentence: ""Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.""?",False, +23980169,Doxorubicin affects hematopoietic and lymphoid system neoplasm,2324,"Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.","Is the triple ""Doxorubicin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.""?",False, +20976248,Doxorubicin affects neuroblastoma,2325,"For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.","Is the triple ""Doxorubicin affects neuroblastoma"" supported by the sentence: ""For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.""?",False, +20526631,Doxorubicin affects gastric neoplasm,2326,"Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.","Is the triple ""Doxorubicin affects gastric neoplasm"" supported by the sentence: ""Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.""?",False, +20464122,Doxorubicin affects T-cell non-Hodgkin lymphoma,2327,"Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.","Is the triple ""Doxorubicin affects T-cell non-Hodgkin lymphoma"" supported by the sentence: ""Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.""?",False, +19907850,Doxorubicin affects renal cell carcinoma,2328,"Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.","Is the triple ""Doxorubicin affects renal cell carcinoma"" supported by the sentence: ""Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.""?",False, +18966824,Doxorubicin affects leiomyosarcoma,2329,"Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.","Is the triple ""Doxorubicin affects leiomyosarcoma"" supported by the sentence: ""Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.""?",False, +18841320,Doxorubicin affects B-cell chronic lymphocytic leukemia,2330,This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.,"Is the triple ""Doxorubicin affects B-cell chronic lymphocytic leukemia"" supported by the sentence: ""This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.""?",False, +17410518,Doxorubicin affects rhabdomyosarcoma,2331,The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.,"Is the triple ""Doxorubicin affects rhabdomyosarcoma"" supported by the sentence: ""The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.""?",False, +17166104,Doxorubicin affects mesothelioma,2332,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""Doxorubicin affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, +17156749,Doxorubicin affects non-Hodgkin lymphoma,2333,From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).,"Is the triple ""Doxorubicin affects non-Hodgkin lymphoma"" supported by the sentence: ""From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).""?",False, +17092174,Doxorubicin affects glioma,2334,Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.,"Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.""?",False, +16319458,Doxorubicin affects sarcoma,2335,Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.,"Is the triple ""Doxorubicin affects sarcoma"" supported by the sentence: ""Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.""?",False, +15641121,Doxorubicin affects liver and intrahepatic bile duct neoplasm,2336,"The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.","Is the triple ""Doxorubicin affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.""?",False, +15592048,Doxorubicin affects diffuse large B-cell lymphoma,2337,"Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.","Is the triple ""Doxorubicin affects diffuse large B-cell lymphoma"" supported by the sentence: ""Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.""?",False, +15335028,Doxorubicin affects pancreatic ductal adenocarcinoma,2338,"We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.","Is the triple ""Doxorubicin affects pancreatic ductal adenocarcinoma"" supported by the sentence: ""We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.""?",False, +15288278,Doxorubicin affects mantle cell lymphoma,2339,"Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.","Is the triple ""Doxorubicin affects mantle cell lymphoma"" supported by the sentence: ""Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.""?",False, +15233880,Doxorubicin affects prostate cancer,2340,"In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.","Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.""?",False, +14862593,Doxorubicin affects liposarcoma,2341,"We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.","Is the triple ""Doxorubicin affects liposarcoma"" supported by the sentence: ""We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.""?",False, +13717435,Doxorubicin affects prostate cancer,2342,CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.,"Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.""?",False, +13641465,Doxorubicin affects Ewing sarcoma,2343,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects Ewing sarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, +13641464,Doxorubicin affects bone osteosarcoma,2344,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects bone osteosarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, +13477582,Doxorubicin affects hepatocellular carcinoma,2345,Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.,"Is the triple ""Doxorubicin affects hepatocellular carcinoma"" supported by the sentence: ""Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.""?",False, +12593977,Doxorubicin affects Kaposi's sarcoma,2346,Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.,"Is the triple ""Doxorubicin affects Kaposi's sarcoma"" supported by the sentence: ""Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.""?",False, +12038917,Doxorubicin affects acute lymphoblastic leukemia,2347,Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.,"Is the triple ""Doxorubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.""?",False, +11963770,Doxorubicin affects angiosarcoma,2348,DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.,"Is the triple ""Doxorubicin affects angiosarcoma"" supported by the sentence: ""DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.""?",False, +11068243,Doxorubicin affects neutropenia,2349,"Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.","Is the triple ""Doxorubicin affects neutropenia"" supported by the sentence: ""Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.""?",False, +9029101,Doxorubicin affects neoplasm,2350,"Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.""?",False, +7957058,Doxorubicin affects neoplasm,2351,"In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.""?",False, +7468708,Doxorubicin affects carcinoma,2352,Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.,"Is the triple ""Doxorubicin affects carcinoma"" supported by the sentence: ""Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.""?",False, +7221748,Doxorubicin affects small cell lung carcinoma,2353,"Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.","Is the triple ""Doxorubicin affects small cell lung carcinoma"" supported by the sentence: ""Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.""?",False, +22415368,Doxorubicin disrupts glioma,2354,"In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.","Is the triple ""Doxorubicin disrupts glioma"" supported by the sentence: ""In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.""?",False, +21775806,Doxorubicin disrupts non-small cell lung carcinoma,2355,Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.,"Is the triple ""Doxorubicin disrupts non-small cell lung carcinoma"" supported by the sentence: ""Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.""?",False, +19908932,Doxorubicin disrupts hematopoietic and lymphoid system neoplasm,2356,Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.,"Is the triple ""Doxorubicin disrupts hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.""?",False, +19216444,Doxorubicin disrupts lymphoma,2357,Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.,"Is the triple ""Doxorubicin disrupts lymphoma"" supported by the sentence: ""Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.""?",False, +18593046,Doxorubicin disrupts bone osteosarcoma,2358,"A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.","Is the triple ""Doxorubicin disrupts bone osteosarcoma"" supported by the sentence: ""A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.""?",False, +17338969,Doxorubicin disrupts melanoma,2359,In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).,"Is the triple ""Doxorubicin disrupts melanoma"" supported by the sentence: ""In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).""?",False, +15233882,Doxorubicin disrupts prostate cancer,2360,"In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.","Is the triple ""Doxorubicin disrupts prostate cancer"" supported by the sentence: ""In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.""?",False, +15026936,Doxorubicin disrupts B-cell neoplasm,2361,"RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.","Is the triple ""Doxorubicin disrupts B-cell neoplasm"" supported by the sentence: ""RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.""?",False, +14123664,Doxorubicin disrupts hepatocellular carcinoma,2362,CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.,"Is the triple ""Doxorubicin disrupts hepatocellular carcinoma"" supported by the sentence: ""CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.""?",False, +11529496,Doxorubicin disrupts neuroblastoma,2363,"We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.","Is the triple ""Doxorubicin disrupts neuroblastoma"" supported by the sentence: ""We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.""?",False, +8800155,Doxorubicin disrupts neoplasm,2364,"Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).","Is the triple ""Doxorubicin disrupts neoplasm"" supported by the sentence: ""Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).""?",False, +8316270,Doxorubicin disrupts Neoplasm Metastasis,2365,"However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.","Is the triple ""Doxorubicin disrupts Neoplasm Metastasis"" supported by the sentence: ""However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.""?",False, +24403937,Doxorubicin prevents triple-negative breast carcinoma,2366,"Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.","Is the triple ""Doxorubicin prevents triple-negative breast carcinoma"" supported by the sentence: ""Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.""?",False, +23195923,Doxorubicin prevents lung neoplasm,2367,In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.,"Is the triple ""Doxorubicin prevents lung neoplasm"" supported by the sentence: ""In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.""?",False, +22365593,Doxorubicin prevents leukemia,2368,"Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.","Is the triple ""Doxorubicin prevents leukemia"" supported by the sentence: ""Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.""?",False, +15227703,Doxorubicin prevents sarcoma,2369,"In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.","Is the triple ""Doxorubicin prevents sarcoma"" supported by the sentence: ""In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.""?",False, +10708896,Doxorubicin prevents urinary bladder neoplasm,2370,"CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.","Is the triple ""Doxorubicin prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.""?",False, +8872024,Doxorubicin prevents Neoplasm Metastasis,2371,"Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.","Is the triple ""Doxorubicin prevents Neoplasm Metastasis"" supported by the sentence: ""Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.""?",False, +8737011,Doxorubicin prevents neutropenia,2372,"CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.","Is the triple ""Doxorubicin prevents neutropenia"" supported by the sentence: ""CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.""?",False, +7721507,Doxorubicin prevents neoplasm,2373,"(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.","Is the triple ""Doxorubicin prevents neoplasm"" supported by the sentence: ""(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.""?",False, +18908502,Doxorubicin exacerbates neoplasm,2374,"Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.","Is the triple ""Doxorubicin exacerbates neoplasm"" supported by the sentence: ""Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.""?",False, +25000938,Doxorubicin predisposes bone osteosarcoma,2375,"CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.","Is the triple ""Doxorubicin predisposes bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.""?",False, +20426915,Doxorubicin predisposes neoplasm,2376,Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.,"Is the triple ""Doxorubicin predisposes neoplasm"" supported by the sentence: ""Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.""?",False, +19669792,Doxorubicin predisposes sarcoma,2377,"Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.","Is the triple ""Doxorubicin predisposes sarcoma"" supported by the sentence: ""Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.""?",False, +18137816,Doxorubicin predisposes lymphoma,2378,"Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.","Is the triple ""Doxorubicin predisposes lymphoma"" supported by the sentence: ""Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.""?",False, +12722667,Doxorubicin predisposes acute myeloid leukemia,2379,"Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.","Is the triple ""Doxorubicin predisposes acute myeloid leukemia"" supported by the sentence: ""Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.""?",False, +8803332,Doxorubicin predisposes kidney Wilms tumor,2380,CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.,"Is the triple ""Doxorubicin predisposes kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.""?",False, +7173827,Doxorubicin predisposes leukemia,2381,"CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.","Is the triple ""Doxorubicin predisposes leukemia"" supported by the sentence: ""CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.""?",False, +26966260,Iproniazid related to Monoamine Oxidase,2382,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, +26966260,Iproniazid related to Monoamine Oxidase,2383,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, +10565399,Iproniazid physically interacts with Monoamine Oxidase,2384,The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.,"Is the triple ""Iproniazid physically interacts with Monoamine Oxidase"" supported by the sentence: ""The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.""?",False, +12902070,Iproniazid affects depressive disorder,2385,"Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.","Is the triple ""Iproniazid affects depressive disorder"" supported by the sentence: ""Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.""?",False, +9833655,Iproniazid affects Monoamine Oxidase,2386,"The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.","Is the triple ""Iproniazid affects Monoamine Oxidase"" supported by the sentence: ""The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.""?",False, +10498318,Epirubicin related to non-small cell lung carcinoma,2387,Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.,"Is the triple ""Epirubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.""?",False, +10228088,Epirubicin related to ovarian cancer,2388,Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.,"Is the triple ""Epirubicin related to ovarian cancer"" supported by the sentence: ""Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.""?",False, +10182077,Epirubicin related to non-Hodgkin lymphoma,2389,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, +10182076,Epirubicin related to Hodgkins lymphoma,2390,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to Hodgkins lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, +8413603,Epirubicin related to small cell lung carcinoma,2391,"Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.","Is the triple ""Epirubicin related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.""?",False, +7746533,Epirubicin related to castration-resistant prostate carcinoma,2392,"The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.","Is the triple ""Epirubicin related to castration-resistant prostate carcinoma"" supported by the sentence: ""The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.""?",False, +26737878,Epirubicin physically interacts with 7-Deoxydoxorubicinone,2393,"In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.","Is the triple ""Epirubicin physically interacts with 7-Deoxydoxorubicinone"" supported by the sentence: ""In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.""?",False, +18781215,Epirubicin causes neoplasm,2394,"In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.","Is the triple ""Epirubicin causes neoplasm"" supported by the sentence: ""In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.""?",False, +26736958,Epirubicin affects hepatocellular carcinoma,2395,"Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.","Is the triple ""Epirubicin affects hepatocellular carcinoma"" supported by the sentence: ""Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.""?",False, +12104701,Epirubicin affects neoplasm,2396,RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.,"Is the triple ""Epirubicin affects neoplasm"" supported by the sentence: ""RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.""?",False, +14784473,Epirubicin prevents neoplasm,2397,"The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.","Is the triple ""Epirubicin prevents neoplasm"" supported by the sentence: ""The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.""?",False, +10544897,Nialamide physically interacts with Monoamine Oxidase,2398,"The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.","Is the triple ""Nialamide physically interacts with Monoamine Oxidase"" supported by the sentence: ""The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.""?",False, +9388429,Nialamide affects Monoamine Oxidase,2399,"Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.","Is the triple ""Nialamide affects Monoamine Oxidase"" supported by the sentence: ""Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.""?",False, +10646811,Isocarboxazid affects Monoamine Oxidase,2400,Monoamine oxidase inhibition by isocarboxazid.,"Is the triple ""Isocarboxazid affects Monoamine Oxidase"" supported by the sentence: ""Monoamine oxidase inhibition by isocarboxazid.""?",False, +14451724,Valacyclovir causes psychotic disorder,2401,"Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.","Is the triple ""Valacyclovir causes psychotic disorder"" supported by the sentence: ""Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.""?",False, +27205274,Valacyclovir affects postherpetic neuralgia,2402,"The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.","Is the triple ""Valacyclovir affects postherpetic neuralgia"" supported by the sentence: ""The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.""?",False, +25557382,Valacyclovir affects Pregnancy,2403,"METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).","Is the triple ""Valacyclovir affects Pregnancy"" supported by the sentence: ""METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).""?",False, +19384061,Valacyclovir disrupts herpes simplex infectious disease,2404,Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.,"Is the triple ""Valacyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.""?",False, +14963245,Valacyclovir disrupts herpes zoster,2405,VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.,"Is the triple ""Valacyclovir disrupts herpes zoster"" supported by the sentence: ""VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.""?",False, +10778326,Valacyclovir disrupts viral infectious disease,2406,"To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.","Is the triple ""Valacyclovir disrupts viral infectious disease"" supported by the sentence: ""To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.""?",False, +10108851,Valacyclovir disrupts herpes labialis,2407,The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.,"Is the triple ""Valacyclovir disrupts herpes labialis"" supported by the sentence: ""The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.""?",False, +8112054,Valacyclovir disrupts genital herpes,2408,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Valacyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, +19368060,Valacyclovir prevents postherpetic neuralgia,2409,FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.,"Is the triple ""Valacyclovir prevents postherpetic neuralgia"" supported by the sentence: ""FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.""?",False, +12346968,Valacyclovir prevents genital herpes,2410,Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.,"Is the triple ""Valacyclovir prevents genital herpes"" supported by the sentence: ""Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.""?",False, +10108849,Valacyclovir prevents herpes labialis,2411,"Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.","Is the triple ""Valacyclovir prevents herpes labialis"" supported by the sentence: ""Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.""?",False, +9970234,Valacyclovir prevents herpes simplex infectious disease,2412,Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.,"Is the triple ""Valacyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.""?",False, +8018684,Valacyclovir prevents cytomegalovirus infection,2413,The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.,"Is the triple ""Valacyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.""?",False, +8899981,Cidofovir affects cytomegalovirus retinitis,2414,The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.,"Is the triple ""Cidofovir affects cytomegalovirus retinitis"" supported by the sentence: ""The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.""?",False, +7346321,Cidofovir affects viral infectious disease,2415,The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.,"Is the triple ""Cidofovir affects viral infectious disease"" supported by the sentence: ""The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.""?",False, +11567412,Cidofovir disrupts cytomegalovirus infection,2416,These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.,"Is the triple ""Cidofovir disrupts cytomegalovirus infection"" supported by the sentence: ""These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.""?",False, +27502123,Cidofovir prevents herpes simplex infectious disease,2417,Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.,"Is the triple ""Cidofovir prevents herpes simplex infectious disease"" supported by the sentence: ""Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.""?",False, +16212718,Cidofovir prevents cytomegalovirus infection,2418,"* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.","Is the triple ""Cidofovir prevents cytomegalovirus infection"" supported by the sentence: ""* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.""?",False, +11248462,Cidofovir prevents viral infectious disease,2419,"Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.","Is the triple ""Cidofovir prevents viral infectious disease"" supported by the sentence: ""Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.""?",False, +26922185,Penciclovir affects viral infectious disease,2420,"Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.","Is the triple ""Penciclovir affects viral infectious disease"" supported by the sentence: ""Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.""?",False, +22087736,Valganciclovir affects cytomegalovirus infection,2421,The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.,"Is the triple ""Valganciclovir affects cytomegalovirus infection"" supported by the sentence: ""The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.""?",False, +18756429,Valganciclovir affects sensorineural hearing loss disorder,2422,IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.,"Is the triple ""Valganciclovir affects sensorineural hearing loss disorder"" supported by the sentence: ""IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.""?",False, +20121657,Valganciclovir disrupts cytomegalovirus infection,2423,"CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.","Is the triple ""Valganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.""?",False, +12085189,Valganciclovir prevents sensorineural hearing loss disorder,2424,"We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.","Is the triple ""Valganciclovir prevents sensorineural hearing loss disorder"" supported by the sentence: ""We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.""?",False, +11282399,Valganciclovir prevents cytomegalovirus infection,2425,"These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.","Is the triple ""Valganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.""?",False, +23156448,Valganciclovir predisposes kidney disorder,2426,"CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?","Is the triple ""Valganciclovir predisposes kidney disorder"" supported by the sentence: ""CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?""?",False, +20121656,Valganciclovir predisposes cytomegalovirus infection,2427,Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.,"Is the triple ""Valganciclovir predisposes cytomegalovirus infection"" supported by the sentence: ""Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.""?",False, +24607675,Remdesivir prevents adult acute respiratory distress syndrome,2428,Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.,"Is the triple ""Remdesivir prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.""?",False, +18302878,Pixantrone related to Deoxyribonucleic acid,2429,"The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.","Is the triple ""Pixantrone related to Deoxyribonucleic acid"" supported by the sentence: ""The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.""?",False, +19964229,Amrubicin affects small cell lung carcinoma,2430,"However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.","Is the triple ""Amrubicin affects small cell lung carcinoma"" supported by the sentence: ""However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.""?",False, +15413207,Amrubicin disrupts neoplasm,2431,"Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.","Is the triple ""Amrubicin disrupts neoplasm"" supported by the sentence: ""Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.""?",False, +16523835,Sevoflurane related to delirium,2432,"Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.","Is the triple ""Sevoflurane related to delirium"" supported by the sentence: ""Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.""?",False, +24969850,Sevoflurane causes adult acute respiratory distress syndrome,2433,This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.,"Is the triple ""Sevoflurane causes adult acute respiratory distress syndrome"" supported by the sentence: ""This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.""?",False, +24682900,Sevoflurane causes acute kidney failure,2434,The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.,"Is the triple ""Sevoflurane causes acute kidney failure"" supported by the sentence: ""The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.""?",False, +18232524,Sevoflurane causes Inflammation,2435,"The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.","Is the triple ""Sevoflurane causes Inflammation"" supported by the sentence: ""The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.""?",False, +17508909,Sevoflurane causes brain injury,2436,These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.,"Is the triple ""Sevoflurane causes brain injury"" supported by the sentence: ""These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.""?",False, +17459839,Sevoflurane causes ischemia reperfusion injury,2437,"BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).","Is the triple ""Sevoflurane causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).""?",False, +11419059,Sevoflurane causes delirium,2438,"Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.","Is the triple ""Sevoflurane causes delirium"" supported by the sentence: ""Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.""?",False, +7326848,Sevoflurane causes Pain,2439,"Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.","Is the triple ""Sevoflurane causes Pain"" supported by the sentence: ""Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.""?",False, +25308865,Sevoflurane affects neoplasm,2440,"Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.","Is the triple ""Sevoflurane affects neoplasm"" supported by the sentence: ""Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.""?",False, +25006055,Sevoflurane affects Pain,2441,Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.,"Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.""?",False, +21710900,Sevoflurane affects obesity disorder,2442,"To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.","Is the triple ""Sevoflurane affects obesity disorder"" supported by the sentence: ""To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.""?",False, +18602416,Sevoflurane affects delirium,2443,The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.,"Is the triple ""Sevoflurane affects delirium"" supported by the sentence: ""The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.""?",False, +17685948,Sevoflurane affects Pain,2444,"Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.","Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.""?",False, +17508906,Sevoflurane affects brain injury,2445,We investigated the effects of sevoflurane on EMP-induced brain injury.,"Is the triple ""Sevoflurane affects brain injury"" supported by the sentence: ""We investigated the effects of sevoflurane on EMP-induced brain injury.""?",False, +13563816,Sevoflurane affects Inflammation,2446,The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.,"Is the triple ""Sevoflurane affects Inflammation"" supported by the sentence: ""The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.""?",False, +7303814,Sevoflurane affects ischemia reperfusion injury,2447,"Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.","Is the triple ""Sevoflurane affects ischemia reperfusion injury"" supported by the sentence: ""Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.""?",False, +22571416,Sevoflurane disrupts myocardial infarction,2448,RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.,"Is the triple ""Sevoflurane disrupts myocardial infarction"" supported by the sentence: ""RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.""?",False, +22138617,Sevoflurane disrupts brain injury,2449,These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.,"Is the triple ""Sevoflurane disrupts brain injury"" supported by the sentence: ""These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.""?",False, +19949689,Sevoflurane disrupts ischemia reperfusion injury,2450,"New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.","Is the triple ""Sevoflurane disrupts ischemia reperfusion injury"" supported by the sentence: ""New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.""?",False, +17977822,Sevoflurane disrupts Inflammation,2451,Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.,"Is the triple ""Sevoflurane disrupts Inflammation"" supported by the sentence: ""Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.""?",False, +24348187,Sevoflurane prevents acute kidney failure,2452,Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.,"Is the triple ""Sevoflurane prevents acute kidney failure"" supported by the sentence: ""Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.""?",False, +24204877,Sevoflurane prevents neoplasm,2453,"BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.","Is the triple ""Sevoflurane prevents neoplasm"" supported by the sentence: ""BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.""?",False, +20028749,Sevoflurane prevents delirium,2454,Sevoflurane might be beneficial for reducing delirium and POCD.,"Is the triple ""Sevoflurane prevents delirium"" supported by the sentence: ""Sevoflurane might be beneficial for reducing delirium and POCD.""?",False, +19290567,Sevoflurane prevents Pain,2455,"CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.","Is the triple ""Sevoflurane prevents Pain"" supported by the sentence: ""CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.""?",False, +16830216,Sevoflurane prevents Inflammation,2456,This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.,"Is the triple ""Sevoflurane prevents Inflammation"" supported by the sentence: ""This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.""?",False, +11671117,Sevoflurane prevents brain injury,2457,Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.,"Is the triple ""Sevoflurane prevents brain injury"" supported by the sentence: ""Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.""?",False, +9664903,Sevoflurane prevents ischemia reperfusion injury,2458,BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.,"Is the triple ""Sevoflurane prevents ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.""?",False, +18320093,Sevoflurane predisposes delirium,2459,"Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.","Is the triple ""Sevoflurane predisposes delirium"" supported by the sentence: ""Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.""?",False, +18121347,Sevoflurane predisposes Inflammation,2460,Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.,"Is the triple ""Sevoflurane predisposes Inflammation"" supported by the sentence: ""Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.""?",False, +24455592,Desflurane causes Postoperative Complications,2461,Desflurane resulted in fewer postoperative complications.,"Is the triple ""Desflurane causes Postoperative Complications"" supported by the sentence: ""Desflurane resulted in fewer postoperative complications.""?",False, +16095968,Heroin related to heroin dependence,2462,The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.,"Is the triple ""Heroin related to heroin dependence"" supported by the sentence: ""The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.""?",False, +9440915,Heroin related to opiate dependence,2463,"This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.","Is the triple ""Heroin related to opiate dependence"" supported by the sentence: ""This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.""?",False, +18531996,Heroin causes heroin dependence,2464,"Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.","Is the triple ""Heroin causes heroin dependence"" supported by the sentence: ""Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.""?",False, +14784390,Heroin causes opiate dependence,2465,A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.,"Is the triple ""Heroin causes opiate dependence"" supported by the sentence: ""A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.""?",False, +19449218,Aluminum hydroxide related to type 1 diabetes mellitus,2466,Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.,"Is the triple ""Aluminum hydroxide related to type 1 diabetes mellitus"" supported by the sentence: ""Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.""?",False, +19135529,Aluminum hydroxide related to malaria,2467,METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.,"Is the triple ""Aluminum hydroxide related to malaria"" supported by the sentence: ""METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.""?",False, +18758930,Aluminum hydroxide related to influenza,2468,Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.,"Is the triple ""Aluminum hydroxide related to influenza"" supported by the sentence: ""Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.""?",False, +15398111,Aluminum hydroxide prevents stomatitis,2469,This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).,"Is the triple ""Aluminum hydroxide prevents stomatitis"" supported by the sentence: ""This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).""?",False, +15812884,Methadone related to heroin dependence,2470,Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.,"Is the triple ""Methadone related to heroin dependence"" supported by the sentence: ""Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.""?",False, +19260564,Methadone causes neonatal abstinence syndrome,2471,"Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.","Is the triple ""Methadone causes neonatal abstinence syndrome"" supported by the sentence: ""Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.""?",False, +18130331,Methadone causes neuralgia,2472,We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.,"Is the triple ""Methadone causes neuralgia"" supported by the sentence: ""We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.""?",False, +18100345,Methadone causes Pain,2473,Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.,"Is the triple ""Methadone causes Pain"" supported by the sentence: ""Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.""?",False, +21405277,Methadone affects opiate dependence,2474,"Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).","Is the triple ""Methadone affects opiate dependence"" supported by the sentence: ""Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).""?",False, +21075382,Methadone affects neoplasm,2475,The analgesic drug methadone is able to sensitize various tumors to chemotherapy.,"Is the triple ""Methadone affects neoplasm"" supported by the sentence: ""The analgesic drug methadone is able to sensitize various tumors to chemotherapy.""?",False, +20010980,Methadone affects Premature birth,2476,They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.,"Is the triple ""Methadone affects Premature birth"" supported by the sentence: ""They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.""?",False, +18302283,Methadone affects Pain,2477,"There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.","Is the triple ""Methadone affects Pain"" supported by the sentence: ""There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.""?",False, +18207522,Methadone affects neonatal abstinence syndrome,2478,"The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.","Is the triple ""Methadone affects neonatal abstinence syndrome"" supported by the sentence: ""The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.""?",False, +18078354,Methadone affects cocaine dependence,2479,"Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.","Is the triple ""Methadone affects cocaine dependence"" supported by the sentence: ""Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.""?",False, +11558529,Methadone affects HIV infectious disease,2480,"OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.","Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.""?",False, +9289228,Methadone affects HIV infectious disease,2481,Methadone enhances human immunodeficiency virus infection of human immune cells.,"Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""Methadone enhances human immunodeficiency virus infection of human immune cells.""?",False, +8979183,Methadone affects neuralgia,2482,Studies are on going to assess the potential role of methadone in treating neuropathic pain.,"Is the triple ""Methadone affects neuralgia"" supported by the sentence: ""Studies are on going to assess the potential role of methadone in treating neuropathic pain.""?",False, +16059875,Methadone disrupts neonatal abstinence syndrome,2483,"Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.","Is the triple ""Methadone disrupts neonatal abstinence syndrome"" supported by the sentence: ""Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.""?",False, +10769844,Methadone disrupts Pain,2484,"However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.","Is the triple ""Methadone disrupts Pain"" supported by the sentence: ""However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.""?",False, +17766557,Methadone prevents hepatitis C virus infection,2485,There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.,"Is the triple ""Methadone prevents hepatitis C virus infection"" supported by the sentence: ""There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.""?",False, +15264750,Methadone prevents opiate dependence,2486,Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.,"Is the triple ""Methadone prevents opiate dependence"" supported by the sentence: ""Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.""?",False, +8905283,Methadone prevents Pain,2487,"In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.","Is the triple ""Methadone prevents Pain"" supported by the sentence: ""In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.""?",False, +8022918,Methadone prevents neonatal abstinence syndrome,2488,Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.,"Is the triple ""Methadone prevents neonatal abstinence syndrome"" supported by the sentence: ""Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.""?",False, +26487110,Methadone predisposes HIV infectious disease,2489,"A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.","Is the triple ""Methadone predisposes HIV infectious disease"" supported by the sentence: ""A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.""?",False, +15424591,Methadone predisposes neonatal abstinence syndrome,2490,CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.,"Is the triple ""Methadone predisposes neonatal abstinence syndrome"" supported by the sentence: ""CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.""?",False, +14491460,Methadone predisposes Premature birth,2491,"CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.","Is the triple ""Methadone predisposes Premature birth"" supported by the sentence: ""CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.""?",False, +26386166,Levomethadyl acetate causes opiate dependence,2492,"Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.","Is the triple ""Levomethadyl acetate causes opiate dependence"" supported by the sentence: ""Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.""?",False, +26901861,Halofantrine prevents malaria,2493,Postexposure administration of halofantrine for the prevention of malaria.,"Is the triple ""Halofantrine prevents malaria"" supported by the sentence: ""Postexposure administration of halofantrine for the prevention of malaria.""?",False, +27668107,Erythropoietin related to HIV infectious disease,2494,"Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.","Is the triple ""Erythropoietin related to HIV infectious disease"" supported by the sentence: ""Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.""?",False, +24695634,Erythropoietin related to optic nerve disorder,2495,Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.,"Is the triple ""Erythropoietin related to optic nerve disorder"" supported by the sentence: ""Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.""?",False, +21186290,Erythropoietin related to Premature birth,2496,"To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.","Is the triple ""Erythropoietin related to Premature birth"" supported by the sentence: ""To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.""?",False, +20871066,Erythropoietin related to necrotizing enterocolitis,2497,"The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.","Is the triple ""Erythropoietin related to necrotizing enterocolitis"" supported by the sentence: ""The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.""?",False, +18130124,Erythropoietin related to mood disorder,2498,Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.,"Is the triple ""Erythropoietin related to mood disorder"" supported by the sentence: ""Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.""?",False, +17186873,Erythropoietin related to ST-elevation myocardial infarction,2499,High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.,"Is the triple ""Erythropoietin related to ST-elevation myocardial infarction"" supported by the sentence: ""High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.""?",False, +16980950,Erythropoietin related to acute myeloid leukemia,2500,The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.,"Is the triple ""Erythropoietin related to acute myeloid leukemia"" supported by the sentence: ""The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.""?",False, +16468663,Erythropoietin related to optic neuritis,2501,"A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.","Is the triple ""Erythropoietin related to optic neuritis"" supported by the sentence: ""A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.""?",False, +16173384,Erythropoietin related to Friedreich ataxia,2502,Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.,"Is the triple ""Erythropoietin related to Friedreich ataxia"" supported by the sentence: ""Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.""?",False, +15054484,Erythropoietin related to breast neoplasm,2503,"EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.","Is the triple ""Erythropoietin related to breast neoplasm"" supported by the sentence: ""EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.""?",False, +14004775,Erythropoietin related to malaria,2504,"To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.","Is the triple ""Erythropoietin related to malaria"" supported by the sentence: ""To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.""?",False, +13955435,Erythropoietin related to chronic renal failure syndrome,2505,[Erythropoietin in the treatment of anemia in chronic renal insufficiency].,"Is the triple ""Erythropoietin related to chronic renal failure syndrome"" supported by the sentence: ""[Erythropoietin in the treatment of anemia in chronic renal insufficiency].""?",False, +13624052,Erythropoietin related to stroke disorder,2506,"Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.","Is the triple ""Erythropoietin related to stroke disorder"" supported by the sentence: ""Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.""?",False, +13580694,Erythropoietin related to Fatigue,2507,Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).,"Is the triple ""Erythropoietin related to Fatigue"" supported by the sentence: ""Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).""?",False, +13206114,Erythropoietin related to sickle cell anemia,2508,Erythropoietin for anemia of renal failure in sickle cell disease.,"Is the triple ""Erythropoietin related to sickle cell anemia"" supported by the sentence: ""Erythropoietin for anemia of renal failure in sickle cell disease.""?",False, +12496787,Erythropoietin related to subarachnoid hemorrhage,2509,Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.,"Is the triple ""Erythropoietin related to subarachnoid hemorrhage"" supported by the sentence: ""Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.""?",False, +12188394,Erythropoietin related to Parkinson disease,2510,"These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.","Is the triple ""Erythropoietin related to Parkinson disease"" supported by the sentence: ""These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.""?",False, +12126135,Erythropoietin related to spinal cord injury,2511,We determined whether EPO and MPSS act synergistically in SCI.,"Is the triple ""Erythropoietin related to spinal cord injury"" supported by the sentence: ""We determined whether EPO and MPSS act synergistically in SCI.""?",False, +11923140,Erythropoietin related to acute kidney failure,2512,Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.,"Is the triple ""Erythropoietin related to acute kidney failure"" supported by the sentence: ""Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.""?",False, +11799479,Erythropoietin related to myocardial infarction,2513,A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.,"Is the triple ""Erythropoietin related to myocardial infarction"" supported by the sentence: ""A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.""?",False, +11734187,Erythropoietin related to multiple sclerosis,2514,Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.,"Is the triple ""Erythropoietin related to multiple sclerosis"" supported by the sentence: ""Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.""?",False, +11580074,Erythropoietin related to ischemia reperfusion injury,2515,We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.,"Is the triple ""Erythropoietin related to ischemia reperfusion injury"" supported by the sentence: ""We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.""?",False, +11529882,Erythropoietin related to myocardial ischemia,2516,"To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.","Is the triple ""Erythropoietin related to myocardial ischemia"" supported by the sentence: ""To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.""?",False, +11452051,Erythropoietin related to prostate cancer,2517,These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.,"Is the triple ""Erythropoietin related to prostate cancer"" supported by the sentence: ""These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.""?",False, +11316441,Erythropoietin related to Ischemic stroke,2518,The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.,"Is the triple ""Erythropoietin related to Ischemic stroke"" supported by the sentence: ""The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.""?",False, +11293850,Erythropoietin related to amyotrophic lateral sclerosis,2519,"Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.","Is the triple ""Erythropoietin related to amyotrophic lateral sclerosis"" supported by the sentence: ""Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.""?",False, +10879812,Erythropoietin related to hepatitis C virus infection,2520,Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.,"Is the triple ""Erythropoietin related to hepatitis C virus infection"" supported by the sentence: ""Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.""?",False, +10348029,Erythropoietin related to neoplasm,2521,We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.,"Is the triple ""Erythropoietin related to neoplasm"" supported by the sentence: ""We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.""?",False, +9392178,Erythropoietin related to injury,2522,Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.,"Is the triple ""Erythropoietin related to injury"" supported by the sentence: ""Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.""?",False, +9089666,Erythropoietin related to chronic myelomonocytic leukemia,2523,Response to erythropoietin in chronic myelomonocytic leukaemia.,"Is the triple ""Erythropoietin related to chronic myelomonocytic leukemia"" supported by the sentence: ""Response to erythropoietin in chronic myelomonocytic leukaemia.""?",False, +8164061,Erythropoietin related to myelodysplastic syndrome,2524,"We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.","Is the triple ""Erythropoietin related to myelodysplastic syndrome"" supported by the sentence: ""We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.""?",False, +7458321,Erythropoietin related to brain ischemia,2525,A potential role for erythropoietin in focal permanent cerebral ischemia in mice.,"Is the triple ""Erythropoietin related to brain ischemia"" supported by the sentence: ""A potential role for erythropoietin in focal permanent cerebral ischemia in mice.""?",False, +7310369,Erythropoietin related to anemia,2526,"The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.","Is the triple ""Erythropoietin related to anemia"" supported by the sentence: ""The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.""?",False, +7231907,Erythropoietin related to chronic kidney disease,2527,Drug usage evaluation of epoetin in chronic renal failure.,"Is the triple ""Erythropoietin related to chronic kidney disease"" supported by the sentence: ""Drug usage evaluation of epoetin in chronic renal failure.""?",False, +7137476,Erythropoietin related to kidney failure,2528,This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.,"Is the triple ""Erythropoietin related to kidney failure"" supported by the sentence: ""This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.""?",False, +12479345,Erythropoietin has part myelodysplastic syndrome,2529,"An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.","Is the triple ""Erythropoietin has part myelodysplastic syndrome"" supported by the sentence: ""An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.""?",False, +9398172,Erythropoietin has part neoplasm,2530,"Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.","Is the triple ""Erythropoietin has part neoplasm"" supported by the sentence: ""Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.""?",False, +27259307,Erythropoietin causes acute kidney failure,2531,"To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.","Is the triple ""Erythropoietin causes acute kidney failure"" supported by the sentence: ""To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.""?",False, +20985522,Erythropoietin causes ischemia reperfusion injury,2532,"RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.","Is the triple ""Erythropoietin causes ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.""?",False, +19282478,Erythropoietin causes neoplasm,2533,"Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.","Is the triple ""Erythropoietin causes neoplasm"" supported by the sentence: ""Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.""?",False, +19178150,Erythropoietin causes spinal cord injury,2534,"AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.","Is the triple ""Erythropoietin causes spinal cord injury"" supported by the sentence: ""AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.""?",False, +18508111,Erythropoietin causes Parkinson disease,2535,"The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.","Is the triple ""Erythropoietin causes Parkinson disease"" supported by the sentence: ""The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.""?",False, +16355442,Erythropoietin causes brain ischemia,2536,"Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.","Is the triple ""Erythropoietin causes brain ischemia"" supported by the sentence: ""Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.""?",False, +15387266,Erythropoietin causes stroke disorder,2537,Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.,"Is the triple ""Erythropoietin causes stroke disorder"" supported by the sentence: ""Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.""?",False, +13935957,Erythropoietin causes injury,2538,OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.,"Is the triple ""Erythropoietin causes injury"" supported by the sentence: ""OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.""?",False, +12824447,Erythropoietin causes chronic kidney disease,2539,"BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.","Is the triple ""Erythropoietin causes chronic kidney disease"" supported by the sentence: ""BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.""?",False, +11912976,Erythropoietin causes myocardial infarction,2540,"Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).","Is the triple ""Erythropoietin causes myocardial infarction"" supported by the sentence: ""Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).""?",False, +11763164,Erythropoietin causes Fatigue,2541,"The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.","Is the triple ""Erythropoietin causes Fatigue"" supported by the sentence: ""The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.""?",False, +9672360,Erythropoietin causes kidney failure,2542,"Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.","Is the triple ""Erythropoietin causes kidney failure"" supported by the sentence: ""Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.""?",False, +9370139,Erythropoietin causes subarachnoid hemorrhage,2543,"A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).","Is the triple ""Erythropoietin causes subarachnoid hemorrhage"" supported by the sentence: ""A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).""?",False, +8009177,Erythropoietin causes anemia,2544,Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.,"Is the triple ""Erythropoietin causes anemia"" supported by the sentence: ""Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.""?",False, +26962810,Erythropoietin affects HIV infectious disease,2545,These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.,"Is the triple ""Erythropoietin affects HIV infectious disease"" supported by the sentence: ""These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.""?",False, +26278974,Erythropoietin affects sickle cell anemia,2546,These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.,"Is the triple ""Erythropoietin affects sickle cell anemia"" supported by the sentence: ""These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.""?",False, +24983690,Erythropoietin affects acute myeloid leukemia,2547,We conclude that both erythropoietin and BPA are appropriately increased in ANLL.,"Is the triple ""Erythropoietin affects acute myeloid leukemia"" supported by the sentence: ""We conclude that both erythropoietin and BPA are appropriately increased in ANLL.""?",False, +20885392,Erythropoietin affects ST-elevation myocardial infarction,2548,Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).,"Is the triple ""Erythropoietin affects ST-elevation myocardial infarction"" supported by the sentence: ""Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).""?",False, +20610677,Erythropoietin affects stroke disorder,2549,"In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.","Is the triple ""Erythropoietin affects stroke disorder"" supported by the sentence: ""In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.""?",False, +18390137,Erythropoietin affects chronic kidney disease,2550,The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.""?",False, +18352546,Erythropoietin affects injury,2551,Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.,"Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.""?",False, +17607901,Erythropoietin affects necrotizing enterocolitis,2552,The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.,"Is the triple ""Erythropoietin affects necrotizing enterocolitis"" supported by the sentence: ""The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.""?",False, +15862945,Erythropoietin affects Ischemic stroke,2553,"To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.","Is the triple ""Erythropoietin affects Ischemic stroke"" supported by the sentence: ""To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.""?",False, +15862785,Erythropoietin affects malaria,2554,"CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.","Is the triple ""Erythropoietin affects malaria"" supported by the sentence: ""CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.""?",False, +15728394,Erythropoietin affects myocardial infarction,2555,"Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.""?",False, +15532613,Erythropoietin affects myocardial infarction,2556,"Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.""?",False, +12937865,Erythropoietin affects anemia,2557,"CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.","Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.""?",False, +12867407,Erythropoietin affects myocardial ischemia,2558,Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.,"Is the triple ""Erythropoietin affects myocardial ischemia"" supported by the sentence: ""Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.""?",False, +11701568,Erythropoietin affects Fatigue,2559,"This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.","Is the triple ""Erythropoietin affects Fatigue"" supported by the sentence: ""This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.""?",False, +11563361,Erythropoietin affects neoplasm,2560,"Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.","Is the triple ""Erythropoietin affects neoplasm"" supported by the sentence: ""Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.""?",False, +10970912,Erythropoietin affects brain injury,2561,BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.,"Is the triple ""Erythropoietin affects brain injury"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.""?",False, +10068762,Erythropoietin affects injury,2562,"Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.","Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.""?",False, +9989127,Erythropoietin affects ischemia reperfusion injury,2563,OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.,"Is the triple ""Erythropoietin affects ischemia reperfusion injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.""?",False, +9392180,Erythropoietin affects spinal cord injury,2564,These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.,"Is the triple ""Erythropoietin affects spinal cord injury"" supported by the sentence: ""These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.""?",False, +8981317,Erythropoietin affects brain ischemia,2565,"When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.","Is the triple ""Erythropoietin affects brain ischemia"" supported by the sentence: ""When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.""?",False, +7400221,Erythropoietin affects chronic kidney disease,2566,Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.""?",False, +7278560,Erythropoietin affects anemia,2567,Erythropoietin elevation in anemia of thermal injury.,"Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""Erythropoietin elevation in anemia of thermal injury.""?",False, +27259305,Erythropoietin produces acute kidney failure,2568,Erythropoietin production in rats with post-ischemic acute renal failure.,"Is the triple ""Erythropoietin produces acute kidney failure"" supported by the sentence: ""Erythropoietin production in rats with post-ischemic acute renal failure.""?",False, +26811591,Erythropoietin produces HIV infectious disease,2569,The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.,"Is the triple ""Erythropoietin produces HIV infectious disease"" supported by the sentence: ""The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.""?",False, +26231858,Erythropoietin produces lymphoma,2570,Renal lymphosarcoma with inappropriate erythropoietin production in a dog.,"Is the triple ""Erythropoietin produces lymphoma"" supported by the sentence: ""Renal lymphosarcoma with inappropriate erythropoietin production in a dog.""?",False, +14673419,Erythropoietin produces myocardial infarction,2571,Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.,"Is the triple ""Erythropoietin produces myocardial infarction"" supported by the sentence: ""Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.""?",False, +11452049,Erythropoietin produces prostate cancer,2572,"To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.","Is the triple ""Erythropoietin produces prostate cancer"" supported by the sentence: ""To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.""?",False, +8829207,Erythropoietin produces neoplasm,2573,The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.,"Is the triple ""Erythropoietin produces neoplasm"" supported by the sentence: ""The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.""?",False, +8032421,Erythropoietin produces chronic renal failure syndrome,2574,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic renal failure syndrome"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, +8032418,Erythropoietin produces chronic kidney disease,2575,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic kidney disease"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, +7919214,Erythropoietin produces anemia,2576,"The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.","Is the triple ""Erythropoietin produces anemia"" supported by the sentence: ""The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.""?",False, +7844664,Erythropoietin produces kidney failure,2577,Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.,"Is the triple ""Erythropoietin produces kidney failure"" supported by the sentence: ""Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.""?",False, +17835656,Erythropoietin disrupts brain injury,2578,"CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.","Is the triple ""Erythropoietin disrupts brain injury"" supported by the sentence: ""CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.""?",False, +17602040,Erythropoietin disrupts Hemorrhage,2579,"CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.","Is the triple ""Erythropoietin disrupts Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.""?",False, +17384804,Erythropoietin disrupts Ischemic stroke,2580,"Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.","Is the triple ""Erythropoietin disrupts Ischemic stroke"" supported by the sentence: ""Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.""?",False, +15027834,Erythropoietin disrupts Fatigue,2581,"In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.","Is the triple ""Erythropoietin disrupts Fatigue"" supported by the sentence: ""In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.""?",False, +13243471,Erythropoietin disrupts chronic kidney disease,2582,"Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).","Is the triple ""Erythropoietin disrupts chronic kidney disease"" supported by the sentence: ""Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).""?",False, +13033535,Erythropoietin disrupts amyotrophic lateral sclerosis,2583,Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.,"Is the triple ""Erythropoietin disrupts amyotrophic lateral sclerosis"" supported by the sentence: ""Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.""?",False, +11253087,Erythropoietin disrupts injury,2584,"Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.","Is the triple ""Erythropoietin disrupts injury"" supported by the sentence: ""Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.""?",False, +8818732,Erythropoietin disrupts anemia,2585,"Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.","Is the triple ""Erythropoietin disrupts anemia"" supported by the sentence: ""Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.""?",False, +22124183,Erythropoietin prevents Premature birth,2586,Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.,"Is the triple ""Erythropoietin prevents Premature birth"" supported by the sentence: ""Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.""?",False, +19522952,Erythropoietin prevents Asphyxia,2587,OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.,"Is the triple ""Erythropoietin prevents Asphyxia"" supported by the sentence: ""OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.""?",False, +17246645,Erythropoietin prevents cerebral palsy,2588,"We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.","Is the triple ""Erythropoietin prevents cerebral palsy"" supported by the sentence: ""We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.""?",False, +16915551,Erythropoietin prevents coronary artery disorder,2589,"Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.","Is the triple ""Erythropoietin prevents coronary artery disorder"" supported by the sentence: ""Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.""?",False, +16468664,Erythropoietin prevents optic neuritis,2590,INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.,"Is the triple ""Erythropoietin prevents optic neuritis"" supported by the sentence: ""INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.""?",False, +16040441,Erythropoietin prevents spinal cord injury,2591,This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.,"Is the triple ""Erythropoietin prevents spinal cord injury"" supported by the sentence: ""This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.""?",False, +15444373,Erythropoietin prevents Parkinson disease,2592,"In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.","Is the triple ""Erythropoietin prevents Parkinson disease"" supported by the sentence: ""In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.""?",False, +14252439,Erythropoietin prevents kidney failure,2593,"The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.","Is the triple ""Erythropoietin prevents kidney failure"" supported by the sentence: ""The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.""?",False, +13347324,Erythropoietin prevents subarachnoid hemorrhage,2594,BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.,"Is the triple ""Erythropoietin prevents subarachnoid hemorrhage"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.""?",False, +13017739,Erythropoietin prevents chronic kidney disease,2595,[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].,"Is the triple ""Erythropoietin prevents chronic kidney disease"" supported by the sentence: ""[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].""?",False, +11480928,Erythropoietin prevents Ischemic stroke,2596,"Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.","Is the triple ""Erythropoietin prevents Ischemic stroke"" supported by the sentence: ""Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.""?",False, +11148609,Erythropoietin prevents myocardial ischemia,2597,"Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.","Is the triple ""Erythropoietin prevents myocardial ischemia"" supported by the sentence: ""Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.""?",False, +11115141,Erythropoietin prevents stroke disorder,2598,"Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.","Is the triple ""Erythropoietin prevents stroke disorder"" supported by the sentence: ""Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.""?",False, +10838253,Erythropoietin prevents necrotizing enterocolitis,2599,Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.,"Is the triple ""Erythropoietin prevents necrotizing enterocolitis"" supported by the sentence: ""Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.""?",False, +10766440,Erythropoietin prevents myocardial infarction,2600,Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.,"Is the triple ""Erythropoietin prevents myocardial infarction"" supported by the sentence: ""Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.""?",False, +10125087,Erythropoietin prevents ischemia reperfusion injury,2601,"HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.","Is the triple ""Erythropoietin prevents ischemia reperfusion injury"" supported by the sentence: ""HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.""?",False, +8434315,Erythropoietin prevents injury,2602,"In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.","Is the triple ""Erythropoietin prevents injury"" supported by the sentence: ""In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.""?",False, +8405867,Erythropoietin prevents brain ischemia,2603,Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.,"Is the triple ""Erythropoietin prevents brain ischemia"" supported by the sentence: ""Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.""?",False, +8369017,Erythropoietin prevents brain injury,2604,Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.,"Is the triple ""Erythropoietin prevents brain injury"" supported by the sentence: ""Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.""?",False, +7400218,Erythropoietin prevents Fatigue,2605,"Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.","Is the triple ""Erythropoietin prevents Fatigue"" supported by the sentence: ""Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.""?",False, +7236347,Erythropoietin prevents anemia,2606,"Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.","Is the triple ""Erythropoietin prevents anemia"" supported by the sentence: ""Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.""?",False, +18610239,Erythropoietin exacerbates injury,2607,"However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.","Is the triple ""Erythropoietin exacerbates injury"" supported by the sentence: ""However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.""?",False, +14126866,Erythropoietin exacerbates anemia,2608,"Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.","Is the triple ""Erythropoietin exacerbates anemia"" supported by the sentence: ""Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.""?",False, +25818939,Erythropoietin predisposes neoplasm,2609,"Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.","Is the triple ""Erythropoietin predisposes neoplasm"" supported by the sentence: ""Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.""?",False, +19869298,Erythropoietin predisposes coronary artery disorder,2610,CONCLUSION: Increased EPO and RDW might be risk factors for CAD.,"Is the triple ""Erythropoietin predisposes coronary artery disorder"" supported by the sentence: ""CONCLUSION: Increased EPO and RDW might be risk factors for CAD.""?",False, +19564296,Erythropoietin predisposes Asphyxia,2611,Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.,"Is the triple ""Erythropoietin predisposes Asphyxia"" supported by the sentence: ""Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.""?",False, +19270398,Erythropoietin predisposes brain injury,2612,"According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.","Is the triple ""Erythropoietin predisposes brain injury"" supported by the sentence: ""According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.""?",False, +18282528,Erythropoietin predisposes chronic kidney disease,2613,"Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.","Is the triple ""Erythropoietin predisposes chronic kidney disease"" supported by the sentence: ""Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.""?",False, +16056103,Erythropoietin predisposes Ischemic stroke,2614,CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.,"Is the triple ""Erythropoietin predisposes Ischemic stroke"" supported by the sentence: ""CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.""?",False, +14483144,Erythropoietin predisposes injury,2615,"METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.","Is the triple ""Erythropoietin predisposes injury"" supported by the sentence: ""METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.""?",False, +12166360,Erythropoietin predisposes kidney failure,2616,Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.,"Is the triple ""Erythropoietin predisposes kidney failure"" supported by the sentence: ""Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.""?",False, +8361116,Erythropoietin predisposes anemia,2617,"Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.","Is the triple ""Erythropoietin predisposes anemia"" supported by the sentence: ""Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.""?",False, +24327196,Daprodustat affects anemia,2618,METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.,"Is the triple ""Daprodustat affects anemia"" supported by the sentence: ""METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.""?",False, +24574810,Daprodustat prevents anemia,2619,Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.,"Is the triple ""Daprodustat prevents anemia"" supported by the sentence: ""Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.""?",False, +19595886,mecobalamin related to vitamin B12 deficiency,2620,Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?,"Is the triple ""mecobalamin related to vitamin B12 deficiency"" supported by the sentence: ""Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?""?",False, +13417310,mecobalamin related to amyotrophic lateral sclerosis,2621,[Clinical trials of ultra-high-dose methylcobalamin in ALS].,"Is the triple ""mecobalamin related to amyotrophic lateral sclerosis"" supported by the sentence: ""[Clinical trials of ultra-high-dose methylcobalamin in ALS].""?",False, +26391120,vitamin B12 related to myocardial infarction,2622,[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].,"Is the triple ""vitamin B12 related to myocardial infarction"" supported by the sentence: ""[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].""?",False, +21860699,vitamin B12 related to type 2 diabetes mellitus,2623,"Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.","Is the triple ""vitamin B12 related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.""?",False, +20662929,vitamin B12 related to non-small cell lung carcinoma,2624,CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.,"Is the triple ""vitamin B12 related to non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.""?",False, +19346996,vitamin B12 related to myocardial ischemia,2625,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""vitamin B12 related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, +12974621,vitamin B12 related to osteoporosis,2626,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""vitamin B12 related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, +10934739,vitamin B12 related to chronic kidney disease,2627,Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.,"Is the triple ""vitamin B12 related to chronic kidney disease"" supported by the sentence: ""Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.""?",False, +10883089,vitamin B12 related to depressive disorder,2628,BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.,"Is the triple ""vitamin B12 related to depressive disorder"" supported by the sentence: ""BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.""?",False, +10658870,vitamin B12 related to psoriasis,2629,Is vitamin B12 of value in psoriasis?,"Is the triple ""vitamin B12 related to psoriasis"" supported by the sentence: ""Is vitamin B12 of value in psoriasis?""?",False, +10535786,vitamin B12 related to atherosclerosis,2630,Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.,"Is the triple ""vitamin B12 related to atherosclerosis"" supported by the sentence: ""Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.""?",False, +10535188,vitamin B12 related to lymphoma,2631,Serum vitamin B12 in leukemias and malignant lymphomas.,"Is the triple ""vitamin B12 related to lymphoma"" supported by the sentence: ""Serum vitamin B12 in leukemias and malignant lymphomas.""?",False, +10508686,vitamin B12 related to vitamin B12 deficiency,2632,[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].,"Is the triple ""vitamin B12 related to vitamin B12 deficiency"" supported by the sentence: ""[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].""?",False, +10438501,vitamin B12 related to iron deficiency anemia,2633,Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.,"Is the triple ""vitamin B12 related to iron deficiency anemia"" supported by the sentence: ""Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.""?",False, +9977774,vitamin B12 related to psychotic disorder,2634,Letter: Vitamin B12 in late-onset psychosis of childhood.,"Is the triple ""vitamin B12 related to psychotic disorder"" supported by the sentence: ""Letter: Vitamin B12 in late-onset psychosis of childhood.""?",False, +9644935,vitamin B12 related to anemia,2635,"However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.","Is the triple ""vitamin B12 related to anemia"" supported by the sentence: ""However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.""?",False, +9118739,vitamin B12 related to Low back pain,2636,"Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.","Is the triple ""vitamin B12 related to Low back pain"" supported by the sentence: ""Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.""?",False, +8678107,vitamin B12 related to Alzheimer disease,2637,"Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.","Is the triple ""vitamin B12 related to Alzheimer disease"" supported by the sentence: ""Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.""?",False, +27330642,vitamin B12 causes depressive disorder,2638,"Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.","Is the triple ""vitamin B12 causes depressive disorder"" supported by the sentence: ""Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.""?",False, +26003936,vitamin B12 causes diabetic neuropathy,2639,Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?,"Is the triple ""vitamin B12 causes diabetic neuropathy"" supported by the sentence: ""Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?""?",False, +17687811,vitamin B12 causes osteoporosis,2640,"In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.","Is the triple ""vitamin B12 causes osteoporosis"" supported by the sentence: ""In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.""?",False, +11993792,vitamin B12 causes Reduced blood folate concentration,2641,RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.,"Is the triple ""vitamin B12 causes Reduced blood folate concentration"" supported by the sentence: ""RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.""?",False, +10806959,vitamin B12 causes psychotic disorder,2642,"Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.","Is the triple ""vitamin B12 causes psychotic disorder"" supported by the sentence: ""Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.""?",False, +10716413,vitamin B12 causes vitamin B12 deficiency,2643,[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].,"Is the triple ""vitamin B12 causes vitamin B12 deficiency"" supported by the sentence: ""[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].""?",False, +9828196,vitamin B12 causes anemia,2644,Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.,"Is the triple ""vitamin B12 causes anemia"" supported by the sentence: ""Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.""?",False, +7900732,vitamin B12 causes atherosclerosis,2645,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""vitamin B12 causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, +25091008,vitamin B12 affects HIV infectious disease,2646,"Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.","Is the triple ""vitamin B12 affects HIV infectious disease"" supported by the sentence: ""Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.""?",False, +20098295,vitamin B12 affects depressive disorder,2647,"At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.""?",False, +19763864,vitamin B12 affects Alzheimer disease,2648,"This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.","Is the triple ""vitamin B12 affects Alzheimer disease"" supported by the sentence: ""This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.""?",False, +18490813,vitamin B12 affects depressive disorder,2649,"In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.""?",False, +17348852,vitamin B12 affects vitamin B12 deficiency,2650,"Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.","Is the triple ""vitamin B12 affects vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.""?",False, +16930257,vitamin B12 affects amyotrophic lateral sclerosis,2651,"Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.","Is the triple ""vitamin B12 affects amyotrophic lateral sclerosis"" supported by the sentence: ""Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.""?",False, +13607058,vitamin B12 affects depressive disorder,2652,"Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.""?",False, +12773836,vitamin B12 affects atherosclerosis,2653,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""vitamin B12 affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, +11945900,vitamin B12 affects Pregnancy,2654,"RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.""?",False, +11927611,vitamin B12 affects diabetic neuropathy,2655,"However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.","Is the triple ""vitamin B12 affects diabetic neuropathy"" supported by the sentence: ""However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.""?",False, +10798681,vitamin B12 affects type 2 diabetes mellitus,2656,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""vitamin B12 affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, +10424959,vitamin B12 affects anemia,2657,[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].,"Is the triple ""vitamin B12 affects anemia"" supported by the sentence: ""[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].""?",False, +8733280,vitamin B12 affects Pregnancy,2658,"The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.""?",False, +8015838,vitamin B12 affects chronic kidney disease,2659,Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.,"Is the triple ""vitamin B12 affects chronic kidney disease"" supported by the sentence: ""Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.""?",False, +23636866,vitamin B12 produces vitamin B12 deficiency,2660,"Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.","Is the triple ""vitamin B12 produces vitamin B12 deficiency"" supported by the sentence: ""Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.""?",False, +11124683,vitamin B12 disrupts chronic kidney disease,2661,"CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.","Is the triple ""vitamin B12 disrupts chronic kidney disease"" supported by the sentence: ""CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.""?",False, +20603701,vitamin B12 prevents Alzheimer disease,2662,"Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.","Is the triple ""vitamin B12 prevents Alzheimer disease"" supported by the sentence: ""Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.""?",False, +14586818,vitamin B12 prevents anemia,2663,"The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.","Is the triple ""vitamin B12 prevents anemia"" supported by the sentence: ""The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.""?",False, +10782972,vitamin B12 prevents atherosclerosis,2664,"Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.","Is the triple ""vitamin B12 prevents atherosclerosis"" supported by the sentence: ""Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.""?",False, +9545669,vitamin B12 prevents vitamin B12 deficiency,2665,Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.,"Is the triple ""vitamin B12 prevents vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.""?",False, +27415421,vitamin B12 predisposes myocardial infarction,2666,"BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).","Is the triple ""vitamin B12 predisposes myocardial infarction"" supported by the sentence: ""BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).""?",False, +21063265,vitamin B12 predisposes depressive disorder,2667,Risk of depression in pregnant women with low-normal serum Vitamin B12.,"Is the triple ""vitamin B12 predisposes depressive disorder"" supported by the sentence: ""Risk of depression in pregnant women with low-normal serum Vitamin B12.""?",False, +20875915,vitamin B12 predisposes chronic kidney disease,2668,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""vitamin B12 predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, +15081186,vitamin B12 predisposes osteoporosis,2669,BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.,"Is the triple ""vitamin B12 predisposes osteoporosis"" supported by the sentence: ""BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.""?",False, +12678935,vitamin B12 predisposes atherosclerosis,2670,"Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.","Is the triple ""vitamin B12 predisposes atherosclerosis"" supported by the sentence: ""Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.""?",False, +12664527,vitamin B12 predisposes Alzheimer disease,2671,"OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.","Is the triple ""vitamin B12 predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.""?",False, +8590188,vitamin B12 predisposes anemia,2672,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""vitamin B12 predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, +22149451,Ipragliflozin affects type 2 diabetes mellitus,2673,"Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.","Is the triple ""Ipragliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.""?",False, +24120079,Ertugliflozin disrupts diabetes mellitus,2674,"Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.","Is the triple ""Ertugliflozin disrupts diabetes mellitus"" supported by the sentence: ""Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.""?",False, +23006843,Empagliflozin related to diabetes mellitus,2675,"We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.","Is the triple ""Empagliflozin related to diabetes mellitus"" supported by the sentence: ""We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.""?",False, +22183651,Empagliflozin related to type 2 diabetes mellitus,2676,Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.,"Is the triple ""Empagliflozin related to type 2 diabetes mellitus"" supported by the sentence: ""Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.""?",False, +24924157,Empagliflozin causes non-alcoholic fatty liver disease,2677,This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.,"Is the triple ""Empagliflozin causes non-alcoholic fatty liver disease"" supported by the sentence: ""This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.""?",False, +23515975,Empagliflozin causes myocardial infarction,2678,"METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).","Is the triple ""Empagliflozin causes myocardial infarction"" supported by the sentence: ""METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).""?",False, +23240834,Empagliflozin causes acute kidney failure,2679,Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.,"Is the triple ""Empagliflozin causes acute kidney failure"" supported by the sentence: ""Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.""?",False, +25094844,Empagliflozin affects diabetes mellitus,2680,Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.,"Is the triple ""Empagliflozin affects diabetes mellitus"" supported by the sentence: ""Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.""?",False, +24520517,Empagliflozin affects Insulin resistance,2681,Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.,"Is the triple ""Empagliflozin affects Insulin resistance"" supported by the sentence: ""Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.""?",False, +24184835,Empagliflozin affects diabetic kidney disease,2682,"Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.","Is the triple ""Empagliflozin affects diabetic kidney disease"" supported by the sentence: ""Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.""?",False, +24091231,Empagliflozin affects kidney disorder,2683,Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.,"Is the triple ""Empagliflozin affects kidney disorder"" supported by the sentence: ""Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.""?",False, +22935616,Empagliflozin affects non-alcoholic fatty liver disease,2684,"Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.","Is the triple ""Empagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.""?",False, +22175650,Empagliflozin affects acute kidney failure,2685,We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.,"Is the triple ""Empagliflozin affects acute kidney failure"" supported by the sentence: ""We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.""?",False, +22027265,Empagliflozin affects type 2 diabetes mellitus,2686,Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.,"Is the triple ""Empagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.""?",False, +21867589,Empagliflozin affects myocardial infarction,2687,Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.,"Is the triple ""Empagliflozin affects myocardial infarction"" supported by the sentence: ""Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.""?",False, +21618629,Empagliflozin affects pulmonary arterial hypertension,2688,"While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.","Is the triple ""Empagliflozin affects pulmonary arterial hypertension"" supported by the sentence: ""While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.""?",False, +22842915,Empagliflozin disrupts type 2 diabetes mellitus,2689,"AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).","Is the triple ""Empagliflozin disrupts type 2 diabetes mellitus"" supported by the sentence: ""AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).""?",False, +23528682,Empagliflozin prevents myocardial infarction,2690,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Empagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, +23286446,Empagliflozin prevents acute kidney failure,2691,"In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.","Is the triple ""Empagliflozin prevents acute kidney failure"" supported by the sentence: ""In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.""?",False, +24551007,Empagliflozin predisposes acute kidney failure,2692,Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.,"Is the triple ""Empagliflozin predisposes acute kidney failure"" supported by the sentence: ""Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.""?",False, +24497752,Empagliflozin predisposes hypoglycemia,2693,We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.,"Is the triple ""Empagliflozin predisposes hypoglycemia"" supported by the sentence: ""We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.""?",False, +23163444,Empagliflozin predisposes diabetic kidney disease,2694,These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.,"Is the triple ""Empagliflozin predisposes diabetic kidney disease"" supported by the sentence: ""These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.""?",False, +21786786,Dapagliflozin related to Alzheimer disease,2695,"For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.","Is the triple ""Dapagliflozin related to Alzheimer disease"" supported by the sentence: ""For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.""?",False, +23582915,Dapagliflozin causes Weight loss,2696,"RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).","Is the triple ""Dapagliflozin causes Weight loss"" supported by the sentence: ""RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).""?",False, +25156234,Dapagliflozin affects non-alcoholic fatty liver disease,2697,The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.,"Is the triple ""Dapagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.""?",False, +23530734,Dapagliflozin affects Albuminuria,2698,The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.,"Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.""?",False, +23107287,Dapagliflozin affects type 1 diabetes mellitus,2699,"In conclusion, dapagliflozin had a significant effect on type 1 diabetes.","Is the triple ""Dapagliflozin affects type 1 diabetes mellitus"" supported by the sentence: ""In conclusion, dapagliflozin had a significant effect on type 1 diabetes.""?",False, +23072376,Dapagliflozin affects ischemia reperfusion injury,2700,"RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.","Is the triple ""Dapagliflozin affects ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.""?",False, +22916804,Dapagliflozin affects diabetic kidney disease,2701,Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.,"Is the triple ""Dapagliflozin affects diabetic kidney disease"" supported by the sentence: ""Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.""?",False, +22845588,Dapagliflozin affects type 2 diabetes mellitus,2702,This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.,"Is the triple ""Dapagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.""?",False, +22578057,Dapagliflozin affects Albuminuria,2703,"The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).","Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).""?",False, +22163310,Dapagliflozin affects Weight loss,2704,The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.,"Is the triple ""Dapagliflozin affects Weight loss"" supported by the sentence: ""The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.""?",False, +21622453,Dapagliflozin affects atrial fibrillation,2705,Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.,"Is the triple ""Dapagliflozin affects atrial fibrillation"" supported by the sentence: ""Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.""?",False, +25362847,Dapagliflozin disrupts acute kidney failure,2706,"Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).","Is the triple ""Dapagliflozin disrupts acute kidney failure"" supported by the sentence: ""Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).""?",False, +23258105,Dapagliflozin disrupts kidney failure,2707,"In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.","Is the triple ""Dapagliflozin disrupts kidney failure"" supported by the sentence: ""In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.""?",False, +22845589,Dapagliflozin disrupts diabetes mellitus,2708,"Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).","Is the triple ""Dapagliflozin disrupts diabetes mellitus"" supported by the sentence: ""Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).""?",False, +23973238,Dapagliflozin prevents type 2 diabetes mellitus,2709,INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .,"Is the triple ""Dapagliflozin prevents type 2 diabetes mellitus"" supported by the sentence: ""INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .""?",False, +23528684,Dapagliflozin prevents myocardial infarction,2710,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Dapagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, +23138841,Dapagliflozin prevents diabetic kidney disease,2711,"Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.","Is the triple ""Dapagliflozin prevents diabetic kidney disease"" supported by the sentence: ""Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.""?",False, +22845590,Dapagliflozin prevents diabetes mellitus,2712,"CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.","Is the triple ""Dapagliflozin prevents diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.""?",False, +22832530,Dapagliflozin prevents kidney failure,2713,BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.,"Is the triple ""Dapagliflozin prevents kidney failure"" supported by the sentence: ""BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.""?",False, +21513723,Dapagliflozin prevents obesity disorder,2714,"We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.","Is the triple ""Dapagliflozin prevents obesity disorder"" supported by the sentence: ""We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.""?",False, +25236689,Dapagliflozin predisposes kidney failure,2715,"CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.","Is the triple ""Dapagliflozin predisposes kidney failure"" supported by the sentence: ""CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.""?",False, +23072379,Dapagliflozin predisposes myocardial infarction,2716,"Also, the administration of DAPA mitigated the production of myocardial infarction markers.","Is the triple ""Dapagliflozin predisposes myocardial infarction"" supported by the sentence: ""Also, the administration of DAPA mitigated the production of myocardial infarction markers.""?",False, +20833370,Methyldopa related to type 1 diabetes mellitus,2717,"SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.","Is the triple ""Methyldopa related to type 1 diabetes mellitus"" supported by the sentence: ""SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.""?",False, +15433400,Methyldopa related to preeclampsia,2718,"Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.","Is the triple ""Methyldopa related to preeclampsia"" supported by the sentence: ""Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.""?",False, +7364754,Methyldopa related to hypertensive disorder,2719,"[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].","Is the triple ""Methyldopa related to hypertensive disorder"" supported by the sentence: ""[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].""?",False, +25805913,Methyldopa causes hypertensive disorder,2720,Letter: Methyldopa-induced hypertension.,"Is the triple ""Methyldopa causes hypertensive disorder"" supported by the sentence: ""Letter: Methyldopa-induced hypertension.""?",False, +23430063,Methyldopa causes preeclampsia,2721,"The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.","Is the triple ""Methyldopa causes preeclampsia"" supported by the sentence: ""The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.""?",False, +26257846,Methyldopa affects hypertensive disorder,2722,"In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.","Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.""?",False, +10671192,Methyldopa affects hypertensive disorder,2723,A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.,"Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.""?",False, +26170425,Methyldopa prevents hypertensive disorder,2724,Methyldopa decreased the supine hypertension and increased the standing blood pressure.,"Is the triple ""Methyldopa prevents hypertensive disorder"" supported by the sentence: ""Methyldopa decreased the supine hypertension and increased the standing blood pressure.""?",False, +8219214,Methyldopa exacerbates hypertensive disorder,2725,Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.,"Is the triple ""Methyldopa exacerbates hypertensive disorder"" supported by the sentence: ""Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.""?",False, +20611289,Methyldopa predisposes preeclampsia,2726,"There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.","Is the triple ""Methyldopa predisposes preeclampsia"" supported by the sentence: ""There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.""?",False, +19343164,Exemestane related to male breast carcinoma,2727,Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.,"Is the triple ""Exemestane related to male breast carcinoma"" supported by the sentence: ""Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.""?",False, +14849934,Exemestane related to ductal breast carcinoma in situ,2728,CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.,"Is the triple ""Exemestane related to ductal breast carcinoma in situ"" supported by the sentence: ""CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.""?",False, +14694867,Exemestane related to non-small cell lung carcinoma,2729,Further studies are needed to assess the activity of exemestane in NSCLC.,"Is the triple ""Exemestane related to non-small cell lung carcinoma"" supported by the sentence: ""Further studies are needed to assess the activity of exemestane in NSCLC.""?",False, +11511167,Exemestane related to neoplasm,2730,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Exemestane related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, +18732584,Exemestane affects neoplasm,2731,"RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).","Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).""?",False, +14063167,Exemestane affects neoplasm,2732,Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.,"Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.""?",False, +16053578,Exemestane prevents breast neoplasm,2733,"However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.","Is the triple ""Exemestane prevents breast neoplasm"" supported by the sentence: ""However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.""?",False, +20235097,Rivizor disrupts neoplasm,2734,Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.,"Is the triple ""Rivizor disrupts neoplasm"" supported by the sentence: ""Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.""?",False, +24226617,Letrozole related to polycystic ovary syndrome,2735,"Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.","Is the triple ""Letrozole related to polycystic ovary syndrome"" supported by the sentence: ""Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.""?",False, +19925368,Letrozole related to infertility disorder,2736,"OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.","Is the triple ""Letrozole related to infertility disorder"" supported by the sentence: ""OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.""?",False, +13004646,Letrozole related to endometriosis,2737,Letrozole and norethisterone acetate in rectovaginal endometriosis.,"Is the triple ""Letrozole related to endometriosis"" supported by the sentence: ""Letrozole and norethisterone acetate in rectovaginal endometriosis.""?",False, +11511165,Letrozole related to neoplasm,2738,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Letrozole related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, +22485512,Letrozole causes infertility disorder,2739,(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.,"Is the triple ""Letrozole causes infertility disorder"" supported by the sentence: ""(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.""?",False, +17708157,Letrozole causes neoplasm,2740,RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.,"Is the triple ""Letrozole causes neoplasm"" supported by the sentence: ""RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.""?",False, +14659251,Letrozole causes endometriosis,2741,"INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.","Is the triple ""Letrozole causes endometriosis"" supported by the sentence: ""INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.""?",False, +11078418,Letrozole causes polycystic ovary syndrome,2742,Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.,"Is the triple ""Letrozole causes polycystic ovary syndrome"" supported by the sentence: ""Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.""?",False, +10282160,Letrozole causes hypogonadism,2743,"In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.","Is the triple ""Letrozole causes hypogonadism"" supported by the sentence: ""In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.""?",False, +25205942,Letrozole affects ovarian hyperstimulation syndrome,2744,Whether letrozole has a direct effect in reducing OHSS requires further investigation.,"Is the triple ""Letrozole affects ovarian hyperstimulation syndrome"" supported by the sentence: ""Whether letrozole has a direct effect in reducing OHSS requires further investigation.""?",False, +18870552,Letrozole affects Pregnancy,2745,CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.,"Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.""?",False, +18835925,Letrozole affects inflammatory breast carcinoma,2746,"The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.","Is the triple ""Letrozole affects inflammatory breast carcinoma"" supported by the sentence: ""The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.""?",False, +10866444,Letrozole affects Pregnancy,2747,"In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.","Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.""?",False, +7871182,Letrozole affects neoplasm,2748,"The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.","Is the triple ""Letrozole affects neoplasm"" supported by the sentence: ""The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.""?",False, +21352213,Letrozole disrupts Pregnancy,2749,"Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).","Is the triple ""Letrozole disrupts Pregnancy"" supported by the sentence: ""Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).""?",False, +25448977,Letrozole prevents prostate cancer,2750,To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.,"Is the triple ""Letrozole prevents prostate cancer"" supported by the sentence: ""To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.""?",False, +19305611,Letrozole prevents Spontaneous abortion,2751,SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.,"Is the triple ""Letrozole prevents Spontaneous abortion"" supported by the sentence: ""SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.""?",False, +17892609,Letrozole prevents ovarian hyperstimulation syndrome,2752,"Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.","Is the triple ""Letrozole prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.""?",False, +13373696,Letrozole prevents neoplasm,2753,"Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).","Is the triple ""Letrozole prevents neoplasm"" supported by the sentence: ""Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).""?",False, +20363763,Letrozole predisposes ovarian hyperstimulation syndrome,2754,Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.,"Is the triple ""Letrozole predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.""?",False, +19305612,Letrozole predisposes Spontaneous abortion,2755,"MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).","Is the triple ""Letrozole predisposes Spontaneous abortion"" supported by the sentence: ""MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).""?",False, +26765214,Formestane affects neoplasm,2756,"In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.","Is the triple ""Formestane affects neoplasm"" supported by the sentence: ""In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.""?",False, +25526748,Formestane disrupts neoplasm,2757,Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.,"Is the triple ""Formestane disrupts neoplasm"" supported by the sentence: ""Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.""?",False, +13022860,Formestane prevents neoplasm,2758,"Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.","Is the triple ""Formestane prevents neoplasm"" supported by the sentence: ""Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.""?",False, +26325498,Aminoglutethimide affects neoplasm,2759,The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.,"Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.""?",False, +12185634,Aminoglutethimide affects neoplasm,2760,"Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.","Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.""?",False, +22275813,Relugolix related to prostate cancer,2761,Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.,"Is the triple ""Relugolix related to prostate cancer"" supported by the sentence: ""Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.""?",False, +23469407,Relugolix prevents Pain,2762,CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.,"Is the triple ""Relugolix prevents Pain"" supported by the sentence: ""CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.""?",False, +25422975,Abiraterone related to castration-resistant prostate carcinoma,2763,CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.,"Is the triple ""Abiraterone related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.""?",False, +20717678,Abiraterone related to prostate cancer,2764,Abiraterone and spironolactone in prostate cancer: a combination to avoid.,"Is the triple ""Abiraterone related to prostate cancer"" supported by the sentence: ""Abiraterone and spironolactone in prostate cancer: a combination to avoid.""?",False, +16721978,Abiraterone affects prostate cancer,2765,The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.,"Is the triple ""Abiraterone affects prostate cancer"" supported by the sentence: ""The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.""?",False, +15794241,Abiraterone prevents neoplasm,2766,"The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.","Is the triple ""Abiraterone prevents neoplasm"" supported by the sentence: ""The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.""?",False, +19010753,Abiraterone predisposes prostate cancer,2767,"The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.","Is the triple ""Abiraterone predisposes prostate cancer"" supported by the sentence: ""The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.""?",False, +11344546,Finasteride related to acne,2768,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to acne"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, +11344545,Finasteride related to alopecia,2769,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to alopecia"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, +9840638,Finasteride related to prostate cancer,2770,CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.,"Is the triple ""Finasteride related to prostate cancer"" supported by the sentence: ""CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.""?",False, +7359591,Finasteride related to benign prostatic hyperplasia,2771,"CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).","Is the triple ""Finasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).""?",False, +21759063,Finasteride causes benign prostatic hyperplasia,2772,"Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.","Is the triple ""Finasteride causes benign prostatic hyperplasia"" supported by the sentence: ""Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.""?",False, +11694493,Finasteride causes prostate cancer,2773,"The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).","Is the triple ""Finasteride causes prostate cancer"" supported by the sentence: ""The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).""?",False, +11326933,Finasteride affects prostate cancer,2774,The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.,"Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.""?",False, +9873046,Finasteride affects benign prostatic hyperplasia,2775,Indeed the effect of finasteride in BPH was proven in clinical studies.,"Is the triple ""Finasteride affects benign prostatic hyperplasia"" supported by the sentence: ""Indeed the effect of finasteride in BPH was proven in clinical studies.""?",False, +9845785,Finasteride affects alopecia,2776,We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.,"Is the triple ""Finasteride affects alopecia"" supported by the sentence: ""We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.""?",False, +7857572,Finasteride affects prostate cancer,2777,"To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.","Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.""?",False, +21155186,Finasteride disrupts benign prostatic hyperplasia,2778,"Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.","Is the triple ""Finasteride disrupts benign prostatic hyperplasia"" supported by the sentence: ""Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.""?",False, +10949204,Finasteride disrupts prostate cancer,2779,The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.,"Is the triple ""Finasteride disrupts prostate cancer"" supported by the sentence: ""The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.""?",False, +7931250,Finasteride disrupts alopecia,2780,Finasteride can also be used to stop male baldness.,"Is the triple ""Finasteride disrupts alopecia"" supported by the sentence: ""Finasteride can also be used to stop male baldness.""?",False, +11279550,Finasteride prevents benign prostatic hyperplasia,2781,Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.,"Is the triple ""Finasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.""?",False, +8938663,Finasteride prevents alopecia,2782,It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.,"Is the triple ""Finasteride prevents alopecia"" supported by the sentence: ""It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.""?",False, +7857569,Finasteride prevents prostate cancer,2783,Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.,"Is the triple ""Finasteride prevents prostate cancer"" supported by the sentence: ""Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.""?",False, +9840634,Finasteride predisposes prostate cancer,2784,"Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).","Is the triple ""Finasteride predisposes prostate cancer"" supported by the sentence: ""Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).""?",False, +8913536,Finasteride predisposes benign prostatic hyperplasia,2785,"CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.","Is the triple ""Finasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.""?",False, +15677403,Dutasteride related to benign prostatic hyperplasia,2786,"CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.","Is the triple ""Dutasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.""?",False, +14665250,Dutasteride related to prostate cancer,2787,"Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.","Is the triple ""Dutasteride related to prostate cancer"" supported by the sentence: ""Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.""?",False, +22506276,Dutasteride causes prostatitis,2788,Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.,"Is the triple ""Dutasteride causes prostatitis"" supported by the sentence: ""Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.""?",False, +14995448,Dutasteride affects prostate cancer,2789,"Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.","Is the triple ""Dutasteride affects prostate cancer"" supported by the sentence: ""Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.""?",False, +11407079,Dutasteride affects prostatitis,2790,"Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.","Is the triple ""Dutasteride affects prostatitis"" supported by the sentence: ""Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.""?",False, +10333399,Dutasteride affects benign prostatic hyperplasia,2791,"OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.","Is the triple ""Dutasteride affects benign prostatic hyperplasia"" supported by the sentence: ""OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.""?",False, +15838005,Dutasteride disrupts prostate cancer,2792,"BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.","Is the triple ""Dutasteride disrupts prostate cancer"" supported by the sentence: ""BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.""?",False, +16876475,Dutasteride prevents benign prostatic hyperplasia,2793,"On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).","Is the triple ""Dutasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).""?",False, +13018366,Dutasteride prevents alopecia,2794,"CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.","Is the triple ""Dutasteride prevents alopecia"" supported by the sentence: ""CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.""?",False, +12506526,Dutasteride prevents prostate cancer,2795,"Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.","Is the triple ""Dutasteride prevents prostate cancer"" supported by the sentence: ""Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.""?",False, +13749427,Dutasteride predisposes benign prostatic hyperplasia,2796,The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.,"Is the triple ""Dutasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.""?",False, +13628345,Dutasteride predisposes prostate cancer,2797,Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.,"Is the triple ""Dutasteride predisposes prostate cancer"" supported by the sentence: ""Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.""?",False, +23122900,Celecoxib related to Pain,2798,"The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.","Is the triple ""Celecoxib related to Pain"" supported by the sentence: ""The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.""?",False, +20821764,Celecoxib related to prostate cancer,2799,"Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.","Is the triple ""Celecoxib related to prostate cancer"" supported by the sentence: ""Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.""?",False, +14485082,Celecoxib related to castration-resistant prostate carcinoma,2800,"Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.","Is the triple ""Celecoxib related to castration-resistant prostate carcinoma"" supported by the sentence: ""Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.""?",False, +14288130,Celecoxib related to neoplasm,2801,"Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).","Is the triple ""Celecoxib related to neoplasm"" supported by the sentence: ""Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).""?",False, +15210658,Celecoxib related to Cyclooxygenase 2,2802,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, +15210658,Celecoxib related to Cyclooxygenase 2,2803,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, +11056859,Celecoxib coexists with Cyclooxygenase 2,2804,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, +11056859,Celecoxib coexists with Cyclooxygenase 2,2805,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, +19664582,Celecoxib coexists with Cyclooxygenase 2,2806,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, +19664582,Celecoxib coexists with Cyclooxygenase 2,2807,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, +8460221,Celecoxib physically interacts with Cyclooxygenase 2,2808,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, +9140190,Celecoxib physically interacts with Cyclooxygenase 2,2809,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, +22101111,Celecoxib causes Alzheimer disease,2810,"In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).","Is the triple ""Celecoxib causes Alzheimer disease"" supported by the sentence: ""In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).""?",False, +21110777,Celecoxib causes schizophrenia,2811,"We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.","Is the triple ""Celecoxib causes schizophrenia"" supported by the sentence: ""We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.""?",False, +20555672,Celecoxib causes hepatocellular carcinoma,2812,"The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.","Is the triple ""Celecoxib causes hepatocellular carcinoma"" supported by the sentence: ""The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.""?",False, +14478589,Celecoxib causes Inflammation,2813,"In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.","Is the triple ""Celecoxib causes Inflammation"" supported by the sentence: ""In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.""?",False, +14396158,Celecoxib causes neoplasm,2814,"In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.","Is the triple ""Celecoxib causes neoplasm"" supported by the sentence: ""In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.""?",False, +13894212,Celecoxib causes peptic ulcer disease,2815,"AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.","Is the triple ""Celecoxib causes peptic ulcer disease"" supported by the sentence: ""AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.""?",False, +13829410,Celecoxib causes Pain,2816,"Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.","Is the triple ""Celecoxib causes Pain"" supported by the sentence: ""Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.""?",False, +12882318,Celecoxib causes colorectal neoplasm,2817,"We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.","Is the triple ""Celecoxib causes colorectal neoplasm"" supported by the sentence: ""We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.""?",False, +12147702,Celecoxib causes osteoarthritis,2818,"CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.","Is the triple ""Celecoxib causes osteoarthritis"" supported by the sentence: ""CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.""?",False, +12029200,Celecoxib causes Hemorrhage,2819,"Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.","Is the triple ""Celecoxib causes Hemorrhage"" supported by the sentence: ""Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.""?",False, +10018014,Celecoxib causes hypertensive disorder,2820,"A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.","Is the triple ""Celecoxib causes hypertensive disorder"" supported by the sentence: ""A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.""?",False, +25555760,Celecoxib affects postpartum depression,2821,"METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.","Is the triple ""Celecoxib affects postpartum depression"" supported by the sentence: ""METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.""?",False, +21116356,Celecoxib affects major depressive disorder,2822,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Celecoxib affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, +19634803,Celecoxib affects Hemorrhage,2823,Therapy: Celecoxib reduces risk of ulcer bleeding.,"Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""Therapy: Celecoxib reduces risk of ulcer bleeding.""?",False, +18087191,Celecoxib affects breast neoplasm,2824,The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.,"Is the triple ""Celecoxib affects breast neoplasm"" supported by the sentence: ""The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.""?",False, +17669654,Celecoxib affects glioma,2825,Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.,"Is the triple ""Celecoxib affects glioma"" supported by the sentence: ""Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.""?",False, +17634409,Celecoxib affects depressive disorder,2826,Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.,"Is the triple ""Celecoxib affects depressive disorder"" supported by the sentence: ""Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.""?",False, +16787676,Celecoxib affects hypertensive disorder,2827,CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.,"Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.""?",False, +15889622,Celecoxib affects osteoarthritis,2828,"Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.","Is the triple ""Celecoxib affects osteoarthritis"" supported by the sentence: ""Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.""?",False, +13667242,Celecoxib affects obesity disorder,2829,"CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.","Is the triple ""Celecoxib affects obesity disorder"" supported by the sentence: ""CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.""?",False, +13414910,Celecoxib affects Hemorrhage,2830,"We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).","Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).""?",False, +13122831,Celecoxib affects hypertensive disorder,2831,"However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.","Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.""?",False, +12419082,Celecoxib affects neoplasm,2832,"In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.""?",False, +11947530,Celecoxib affects hepatocellular carcinoma,2833,Antitumoral effect of celecoxib in hepatocellular carcinoma.,"Is the triple ""Celecoxib affects hepatocellular carcinoma"" supported by the sentence: ""Antitumoral effect of celecoxib in hepatocellular carcinoma.""?",False, +11444192,Celecoxib affects neoplasm,2834,"Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.""?",False, +11303331,Celecoxib affects non-small cell lung carcinoma,2835,"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.","Is the triple ""Celecoxib affects non-small cell lung carcinoma"" supported by the sentence: ""Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.""?",False, +10337670,Celecoxib affects colorectal neoplasm,2836,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Celecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, +10157341,Celecoxib affects injury,2837,"Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.","Is the triple ""Celecoxib affects injury"" supported by the sentence: ""Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.""?",False, +9967873,Celecoxib affects Palmar-plantar erythrodysesthesia syndrome,2838,Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.,"Is the triple ""Celecoxib affects Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.""?",False, +9574485,Celecoxib affects schizophrenia,2839,"METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.","Is the triple ""Celecoxib affects schizophrenia"" supported by the sentence: ""METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.""?",False, +9038473,Celecoxib affects peptic ulcer disease,2840,"The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.","Is the triple ""Celecoxib affects peptic ulcer disease"" supported by the sentence: ""The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.""?",False, +7841958,Celecoxib affects rheumatoid arthritis,2841,Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.,"Is the triple ""Celecoxib affects rheumatoid arthritis"" supported by the sentence: ""Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.""?",False, +7726669,Celecoxib affects Pain,2842,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Pain"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, +7726668,Celecoxib affects Inflammation,2843,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Inflammation"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, +7264055,Celecoxib affects Cyclooxygenase 2,2844,"Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.""?",False, +11464194,Celecoxib affects Cyclooxygenase 2,2845,"In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.""?",False, +11846592,Celecoxib produces Cyclooxygenase 2,2846,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, +11846592,Celecoxib produces Cyclooxygenase 2,2847,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, +14865798,Celecoxib has input Cyclooxygenase 2,2848,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, +14865798,Celecoxib has input Cyclooxygenase 2,2849,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, +22029254,Celecoxib disrupts major depressive disorder,2850,Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.,"Is the triple ""Celecoxib disrupts major depressive disorder"" supported by the sentence: ""Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.""?",False, +16862201,Celecoxib disrupts hepatocellular carcinoma,2851,"Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.","Is the triple ""Celecoxib disrupts hepatocellular carcinoma"" supported by the sentence: ""Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.""?",False, +15337601,Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome,2852,"RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).","Is the triple ""Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).""?",False, +15029907,Celecoxib disrupts Pain,2853,"RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.","Is the triple ""Celecoxib disrupts Pain"" supported by the sentence: ""RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.""?",False, +14234726,Celecoxib disrupts adenoma,2854,"Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.","Is the triple ""Celecoxib disrupts adenoma"" supported by the sentence: ""Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.""?",False, +12025752,Celecoxib disrupts colonic neoplasm,2855,Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.,"Is the triple ""Celecoxib disrupts colonic neoplasm"" supported by the sentence: ""Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.""?",False, +9589598,Celecoxib disrupts neoplasm,2856,"RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.","Is the triple ""Celecoxib disrupts neoplasm"" supported by the sentence: ""RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.""?",False, +9384934,Celecoxib disrupts breast neoplasm,2857,Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.,"Is the triple ""Celecoxib disrupts breast neoplasm"" supported by the sentence: ""Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.""?",False, +8528907,Celecoxib disrupts Inflammation,2858,"Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).","Is the triple ""Celecoxib disrupts Inflammation"" supported by the sentence: ""Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).""?",False, +19393781,Celecoxib prevents stroke disorder,2859,"Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].","Is the triple ""Celecoxib prevents stroke disorder"" supported by the sentence: ""Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].""?",False, +18309561,Celecoxib prevents hepatocellular carcinoma,2860,"In addition, celecoxib was found to significantly reduce HCC progression.","Is the triple ""Celecoxib prevents hepatocellular carcinoma"" supported by the sentence: ""In addition, celecoxib was found to significantly reduce HCC progression.""?",False, +17468664,Celecoxib prevents non-small cell lung carcinoma,2861,"In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.","Is the triple ""Celecoxib prevents non-small cell lung carcinoma"" supported by the sentence: ""In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.""?",False, +16386169,Celecoxib prevents actinic keratosis,2862,QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?,"Is the triple ""Celecoxib prevents actinic keratosis"" supported by the sentence: ""QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?""?",False, +16323754,Celecoxib prevents hypertensive disorder,2863,"RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.","Is the triple ""Celecoxib prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.""?",False, +15947575,Celecoxib prevents osteoarthritis,2864,"OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.","Is the triple ""Celecoxib prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.""?",False, +15337603,Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome,2865,"CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.","Is the triple ""Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.""?",False, +14688780,Celecoxib prevents Low back pain,2866,RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.,"Is the triple ""Celecoxib prevents Low back pain"" supported by the sentence: ""RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.""?",False, +13346756,Celecoxib prevents prostate cancer,2867,A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.,"Is the triple ""Celecoxib prevents prostate cancer"" supported by the sentence: ""A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.""?",False, +12969778,Celecoxib prevents neuroblastoma,2868,Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.,"Is the triple ""Celecoxib prevents neuroblastoma"" supported by the sentence: ""Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.""?",False, +12687466,Celecoxib prevents adenoma,2869,Risks and benefits of celecoxib to prevent recurrent adenomas.,"Is the triple ""Celecoxib prevents adenoma"" supported by the sentence: ""Risks and benefits of celecoxib to prevent recurrent adenomas.""?",False, +11060421,Celecoxib prevents classic familial adenomatous polyposis,2870,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Celecoxib prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, +10931690,Celecoxib prevents breast neoplasm,2871,"The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.","Is the triple ""Celecoxib prevents breast neoplasm"" supported by the sentence: ""The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.""?",False, +10337661,Celecoxib prevents colorectal neoplasm,2872,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Celecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, +9969498,Celecoxib prevents Acute Pain,2873,"Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.","Is the triple ""Celecoxib prevents Acute Pain"" supported by the sentence: ""Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.""?",False, +9525867,Celecoxib prevents injury,2874,Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.,"Is the triple ""Celecoxib prevents injury"" supported by the sentence: ""Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.""?",False, +9508533,Celecoxib prevents Pain,2875,IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.,"Is the triple ""Celecoxib prevents Pain"" supported by the sentence: ""IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.""?",False, +8844228,Celecoxib prevents Inflammation,2876,"Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.","Is the triple ""Celecoxib prevents Inflammation"" supported by the sentence: ""Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.""?",False, +7720173,Celecoxib prevents neoplasm,2877,The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.,"Is the triple ""Celecoxib prevents neoplasm"" supported by the sentence: ""The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.""?",False, +14426267,Celecoxib predisposes Inflammation,2878,"In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.","Is the triple ""Celecoxib predisposes Inflammation"" supported by the sentence: ""In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.""?",False, +12799788,Celecoxib predisposes hypertensive disorder,2879,"Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.","Is the triple ""Celecoxib predisposes hypertensive disorder"" supported by the sentence: ""Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.""?",False, +11130431,Celecoxib predisposes injury,2880,CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.,"Is the triple ""Celecoxib predisposes injury"" supported by the sentence: ""CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.""?",False, +12352394,Rofecoxib related to Cyclooxygenase 2,2881,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, +12352394,Rofecoxib related to Cyclooxygenase 2,2882,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, +14685035,Rofecoxib related to Cyclooxygenase 2,2883,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, +14685035,Rofecoxib related to Cyclooxygenase 2,2884,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, +8460222,Rofecoxib physically interacts with Cyclooxygenase 2,2885,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, +9140191,Rofecoxib physically interacts with Cyclooxygenase 2,2886,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, +10265772,Rofecoxib causes Pain,2887,We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.,"Is the triple ""Rofecoxib causes Pain"" supported by the sentence: ""We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.""?",False, +13140649,Rofecoxib affects Pain,2888,"Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.","Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.""?",False, +13143485,Rofecoxib affects osteoarthritis,2889,Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).""?",False, +12129893,Rofecoxib affects adenoma,2890,Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.,"Is the triple ""Rofecoxib affects adenoma"" supported by the sentence: ""Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.""?",False, +11539323,Rofecoxib affects Pain,2891,Effect of rofecoxib on pain caused by osteoid osteoma.,"Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Effect of rofecoxib on pain caused by osteoid osteoma.""?",False, +10337671,Rofecoxib affects colorectal neoplasm,2892,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Rofecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, +8436303,Rofecoxib affects osteoarthritis,2893,The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.""?",False, +7546790,Rofecoxib affects Cyclooxygenase 2,2894,"Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.""?",False, +11143316,Rofecoxib affects Cyclooxygenase 2,2895,"Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.""?",False, +11899486,Rofecoxib disrupts Pain,2896,Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.,"Is the triple ""Rofecoxib disrupts Pain"" supported by the sentence: ""Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.""?",False, +12422414,Rofecoxib prevents adenoma,2897,BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.,"Is the triple ""Rofecoxib prevents adenoma"" supported by the sentence: ""BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.""?",False, +10337662,Rofecoxib prevents colorectal neoplasm,2898,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Rofecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, +9488144,Rofecoxib prevents Pain,2899,"This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.","Is the triple ""Rofecoxib prevents Pain"" supported by the sentence: ""This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.""?",False, +12808149,Rofecoxib predisposes adenoma,2900,Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).,"Is the triple ""Rofecoxib predisposes adenoma"" supported by the sentence: ""Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).""?",False, +21440548,Etoricoxib affects osteoarthritis,2901,"In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.","Is the triple ""Etoricoxib affects osteoarthritis"" supported by the sentence: ""In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.""?",False, +17783506,Etoricoxib affects injury,2902,The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.,"Is the triple ""Etoricoxib affects injury"" supported by the sentence: ""The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.""?",False, +15015650,Etoricoxib affects Pain,2903,DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.,"Is the triple ""Etoricoxib affects Pain"" supported by the sentence: ""DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.""?",False, +13276651,Etoricoxib affects rheumatic disorder,2904,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Etoricoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, +8656381,Etoricoxib affects Cyclooxygenase 2,2905,"In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.","Is the triple ""Etoricoxib affects Cyclooxygenase 2"" supported by the sentence: ""In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.""?",False, +21271381,Etoricoxib prevents osteoarthritis,2906,The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.,"Is the triple ""Etoricoxib prevents osteoarthritis"" supported by the sentence: ""The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.""?",False, +17783508,Etoricoxib prevents injury,2907,The results of this study show that etoricoxib treatment could decrease kidney injury during IR.,"Is the triple ""Etoricoxib prevents injury"" supported by the sentence: ""The results of this study show that etoricoxib treatment could decrease kidney injury during IR.""?",False, +13679347,Etoricoxib prevents Pain,2908,CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.,"Is the triple ""Etoricoxib prevents Pain"" supported by the sentence: ""CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.""?",False, +11619190,Lumiracoxib coexists with Cyclooxygenase 2,2909,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, +11619190,Lumiracoxib coexists with Cyclooxygenase 2,2910,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, +17164065,Lumiracoxib physically interacts with Cyclooxygenase 2,2911,The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.,"Is the triple ""Lumiracoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.""?",False, +13276652,Lumiracoxib affects rheumatic disorder,2912,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Lumiracoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, +10245332,Lumiracoxib affects Cyclooxygenase 2,2913,"Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.","Is the triple ""Lumiracoxib affects Cyclooxygenase 2"" supported by the sentence: ""Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.""?",False, +13077914,Valdecoxib physically interacts with Cyclooxygenase 2,2914,We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.,"Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.""?",False, +11476053,Valdecoxib physically interacts with Cyclooxygenase 2,2915,"Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).","Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).""?",False, +9552647,Valdecoxib affects Cyclooxygenase 2,2916,"Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].","Is the triple ""Valdecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].""?",False, +11215677,Valdecoxib disrupts Pain,2917,Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.,"Is the triple ""Valdecoxib disrupts Pain"" supported by the sentence: ""Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.""?",False, +15156435,Valdecoxib prevents pancreatitis,2918,CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.,"Is the triple ""Valdecoxib prevents pancreatitis"" supported by the sentence: ""CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.""?",False, +10035578,Valdecoxib prevents Pain,2919,"Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.","Is the triple ""Valdecoxib prevents Pain"" supported by the sentence: ""Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.""?",False, +17909160,Parecoxib coexists with Cyclooxygenase 2,2920,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, +17909160,Parecoxib coexists with Cyclooxygenase 2,2921,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, +16597136,Parecoxib affects Shoulder pain,2922,BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.,"Is the triple ""Parecoxib affects Shoulder pain"" supported by the sentence: ""BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.""?",False, +13492238,Parecoxib affects Pain,2923,Preventive effects of perioperative parecoxib on post-discectomy pain.,"Is the triple ""Parecoxib affects Pain"" supported by the sentence: ""Preventive effects of perioperative parecoxib on post-discectomy pain.""?",False, +12600950,Parecoxib affects Cyclooxygenase 2,2924,Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.,"Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.""?",False, +18579418,Parecoxib affects Cyclooxygenase 2,2925,"While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).","Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).""?",False, +18207264,Parecoxib disrupts Pain,2926,"Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).","Is the triple ""Parecoxib disrupts Pain"" supported by the sentence: ""Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).""?",False, +16597135,Parecoxib prevents Shoulder pain,2927,"Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.","Is the triple ""Parecoxib prevents Shoulder pain"" supported by the sentence: ""Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.""?",False, +14081775,Parecoxib prevents Pain,2928,RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.,"Is the triple ""Parecoxib prevents Pain"" supported by the sentence: ""RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.""?",False, +22281663,Drospirenone related to polycystic ovary syndrome,2929,"METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.","Is the triple ""Drospirenone related to polycystic ovary syndrome"" supported by the sentence: ""METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.""?",False, +21546756,Drospirenone related to acne,2930,"Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).","Is the triple ""Drospirenone related to acne"" supported by the sentence: ""Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).""?",False, +20964606,Drospirenone predisposes polycystic ovary syndrome,2931,"Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.","Is the triple ""Drospirenone predisposes polycystic ovary syndrome"" supported by the sentence: ""Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.""?",False, +8455182,Ropinirole related to Parkinson disease,2932,Ropinirole as compared with levodopa in Parkinson's disease.,"Is the triple ""Ropinirole related to Parkinson disease"" supported by the sentence: ""Ropinirole as compared with levodopa in Parkinson's disease.""?",False, +17774585,Ropinirole causes Parkinson disease,2933,"Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.","Is the triple ""Ropinirole causes Parkinson disease"" supported by the sentence: ""Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.""?",False, +14587825,Ropinirole affects Parkinson disease,2934,An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.,"Is the triple ""Ropinirole affects Parkinson disease"" supported by the sentence: ""An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.""?",False, +11791368,Ropinirole affects restless legs syndrome,2935,The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.,"Is the triple ""Ropinirole affects restless legs syndrome"" supported by the sentence: ""The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.""?",False, +9334943,Ropinirole disrupts Parkinson disease,2936,"A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).","Is the triple ""Ropinirole disrupts Parkinson disease"" supported by the sentence: ""A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).""?",False, +10286489,Ropinirole prevents Parkinson disease,2937,"Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.","Is the triple ""Ropinirole prevents Parkinson disease"" supported by the sentence: ""Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.""?",False, +27727471,Pergolide related to Parkinson disease,2938,Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.,"Is the triple ""Pergolide related to Parkinson disease"" supported by the sentence: ""Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.""?",False, +11914502,Pergolide causes Parkinson disease,2939,"The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.","Is the triple ""Pergolide causes Parkinson disease"" supported by the sentence: ""The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.""?",False, +10881399,Pergolide affects Parkinson disease,2940,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pergolide affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, +16163315,Bromocriptine related to Parkinson disease,2941,Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.,"Is the triple ""Bromocriptine related to Parkinson disease"" supported by the sentence: ""Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.""?",False, +15233295,Bromocriptine related to type 1 diabetes mellitus,2942,Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.,"Is the triple ""Bromocriptine related to type 1 diabetes mellitus"" supported by the sentence: ""Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.""?",False, +17352665,Bromocriptine causes obesity disorder,2943,"SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.","Is the triple ""Bromocriptine causes obesity disorder"" supported by the sentence: ""SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.""?",False, +12630193,Bromocriptine causes Parkinson disease,2944,"The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.","Is the triple ""Bromocriptine causes Parkinson disease"" supported by the sentence: ""The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.""?",False, +22488533,Bromocriptine affects adenomyosis,2945,The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.,"Is the triple ""Bromocriptine affects adenomyosis"" supported by the sentence: ""The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.""?",False, +20888778,Bromocriptine affects Parkinson disease,2946,"Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.","Is the triple ""Bromocriptine affects Parkinson disease"" supported by the sentence: ""Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.""?",False, +27647530,Bromocriptine prevents obesity disorder,2947,"Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.","Is the triple ""Bromocriptine prevents obesity disorder"" supported by the sentence: ""Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.""?",False, +15529387,Bromocriptine prevents ovarian hyperstimulation syndrome,2948,Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.,"Is the triple ""Bromocriptine prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.""?",False, +18216941,Piribedil causes Parkinson disease,2949,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Piribedil causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, +8408670,Piribedil affects Parkinson disease,2950,Action of piribedil in Parkinson's disease: I.V. test and oral treatment.,"Is the triple ""Piribedil affects Parkinson disease"" supported by the sentence: ""Action of piribedil in Parkinson's disease: I.V. test and oral treatment.""?",False, +8818724,Apomorphine related to Parkinson disease,2951,The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine related to Parkinson disease"" supported by the sentence: ""The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.""?",False, +23018637,Apomorphine causes erectile dysfunction,2952,Apomorphine was used to induce diabetic erectile dysfunction.,"Is the triple ""Apomorphine causes erectile dysfunction"" supported by the sentence: ""Apomorphine was used to induce diabetic erectile dysfunction.""?",False, +11364291,Apomorphine causes Parkinson disease,2953,"Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.","Is the triple ""Apomorphine causes Parkinson disease"" supported by the sentence: ""Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.""?",False, +8320181,Apomorphine affects Parkinson disease,2954,The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine affects Parkinson disease"" supported by the sentence: ""The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.""?",False, +16869339,Cabergoline related to Parkinson disease,2955,OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).,"Is the triple ""Cabergoline related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).""?",False, +19536611,Cabergoline physically interacts with Dopamine D2 Receptor,2956,CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.,"Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.""?",False, +15320456,Cabergoline physically interacts with Dopamine D2 Receptor,2957,"In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.","Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.""?",False, +20751353,Cabergoline causes endometriosis,2958,"Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).","Is the triple ""Cabergoline causes endometriosis"" supported by the sentence: ""Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).""?",False, +26585560,Cabergoline affects pituitary tumor,2959,The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.,"Is the triple ""Cabergoline affects pituitary tumor"" supported by the sentence: ""The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.""?",False, +19237315,Cabergoline affects endometriosis,2960,Effect of Cabergoline in Experimental Endometriosis in Rats.,"Is the triple ""Cabergoline affects endometriosis"" supported by the sentence: ""Effect of Cabergoline in Experimental Endometriosis in Rats.""?",False, +17463083,Cabergoline affects Dopamine D2 Receptor,2961,Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.,"Is the triple ""Cabergoline affects Dopamine D2 Receptor"" supported by the sentence: ""Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.""?",False, +12695381,Cabergoline affects ovarian hyperstimulation syndrome,2962,OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.,"Is the triple ""Cabergoline affects ovarian hyperstimulation syndrome"" supported by the sentence: ""OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.""?",False, +13380476,Cabergoline prevents ovarian hyperstimulation syndrome,2963,Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.,"Is the triple ""Cabergoline prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.""?",False, +9194241,Cabergoline predisposes ovarian hyperstimulation syndrome,2964,"CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.","Is the triple ""Cabergoline predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.""?",False, +15982499,Pramipexole related to restless legs syndrome,2965,"Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.","Is the triple ""Pramipexole related to restless legs syndrome"" supported by the sentence: ""Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.""?",False, +9735890,Pramipexole related to Parkinson disease,2966,Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.,"Is the triple ""Pramipexole related to Parkinson disease"" supported by the sentence: ""Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.""?",False, +21401262,Pramipexole causes restless legs syndrome,2967,Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.,"Is the triple ""Pramipexole causes restless legs syndrome"" supported by the sentence: ""Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.""?",False, +15033700,Pramipexole causes obsessive-compulsive disorder,2968,"CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.","Is the triple ""Pramipexole causes obsessive-compulsive disorder"" supported by the sentence: ""CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.""?",False, +13328857,Pramipexole causes Parkinson disease,2969,"We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.","Is the triple ""Pramipexole causes Parkinson disease"" supported by the sentence: ""We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.""?",False, +18143671,Pramipexole affects depressive disorder,2970,The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.,"Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.""?",False, +12990655,Pramipexole affects restless legs syndrome,2971,The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.,"Is the triple ""Pramipexole affects restless legs syndrome"" supported by the sentence: ""The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.""?",False, +12579916,Pramipexole affects depressive disorder,2972,"Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.","Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.""?",False, +10881401,Pramipexole affects Parkinson disease,2973,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pramipexole affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, +11457313,Pramipexole prevents Parkinson disease,2974,"Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.","Is the triple ""Pramipexole prevents Parkinson disease"" supported by the sentence: ""Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.""?",False, +24610805,Rotigotine affects Parkinson disease,2975,"A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.","Is the triple ""Rotigotine affects Parkinson disease"" supported by the sentence: ""A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.""?",False, +10840977,Norethindrone subclass of Norethindrone acetate,2976,"Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.","Is the triple ""Norethindrone subclass of Norethindrone acetate"" supported by the sentence: ""Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.""?",False, +8232443,Norethindrone related to Norethindrone acetate,2977,"The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.","Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.""?",False, +11686400,Norethindrone related to Norethindrone acetate,2978,OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).,"Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).""?",False, +9474851,Norethindrone coexists with Norethindrone acetate,2979,"The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.","Is the triple ""Norethindrone coexists with Norethindrone acetate"" supported by the sentence: ""The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.""?",False, +9781055,Norethindrone physically interacts with Norethindrone acetate,2980,"Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.","Is the triple ""Norethindrone physically interacts with Norethindrone acetate"" supported by the sentence: ""Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.""?",False, +21462883,Norethindrone causes neoplasm,2981,"Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.","Is the triple ""Norethindrone causes neoplasm"" supported by the sentence: ""Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.""?",False, +27429354,Pramocaine affects Pruritus,2982,Effect of topical pramoxine on experimentally induced pruritus in humans.,"Is the triple ""Pramocaine affects Pruritus"" supported by the sentence: ""Effect of topical pramoxine on experimentally induced pruritus in humans.""?",False, +19275366,Miconazole disrupts fungal infectious disease,2983,"Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.","Is the triple ""Miconazole disrupts fungal infectious disease"" supported by the sentence: ""Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.""?",False, +26511975,Miconazole prevents fungal infectious disease,2984,"The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.","Is the triple ""Miconazole prevents fungal infectious disease"" supported by the sentence: ""The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.""?",False, +26530559,Benzocaine affects Pain,2985,OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.,"Is the triple ""Benzocaine affects Pain"" supported by the sentence: ""OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.""?",False, +8870493,Benzocaine disrupts Pain,2986,CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.,"Is the triple ""Benzocaine disrupts Pain"" supported by the sentence: ""CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.""?",False, +8870496,Benzocaine prevents Pain,2987,"Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.","Is the triple ""Benzocaine prevents Pain"" supported by the sentence: ""Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.""?",False, +25561815,Folic Acid related to systemic lupus erythematosus,2988,Folic acid in systemic lupus erythematosus - a new aspect.,"Is the triple ""Folic Acid related to systemic lupus erythematosus"" supported by the sentence: ""Folic acid in systemic lupus erythematosus - a new aspect.""?",False, +23703706,Folic Acid related to neoplasm of esophagus,2989,"We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.","Is the triple ""Folic Acid related to neoplasm of esophagus"" supported by the sentence: ""We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.""?",False, +23248765,Folic Acid related to chronic renal failure syndrome,2990,"Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.","Is the triple ""Folic Acid related to chronic renal failure syndrome"" supported by the sentence: ""Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.""?",False, +20038856,Folic Acid related to psychotic disorder,2991,Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.,"Is the triple ""Folic Acid related to psychotic disorder"" supported by the sentence: ""Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.""?",False, +19346997,Folic Acid related to myocardial ischemia,2992,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""Folic Acid related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, +19301020,Folic Acid related to type 2 diabetes mellitus,2993,"In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.","Is the triple ""Folic Acid related to type 2 diabetes mellitus"" supported by the sentence: ""In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.""?",False, +19114314,Folic Acid related to tuberculosis,2994,Information about folate status in tuberculosis in developing countries is scanty.,"Is the triple ""Folic Acid related to tuberculosis"" supported by the sentence: ""Information about folate status in tuberculosis in developing countries is scanty.""?",False, +18323097,Folic Acid related to HIV infectious disease,2995,"CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.","Is the triple ""Folic Acid related to HIV infectious disease"" supported by the sentence: ""CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.""?",False, +17591518,Folic Acid related to infertility disorder,2996,Folate is one of the B vitamins which has been suggested to be related to infertility.,"Is the triple ""Folic Acid related to infertility disorder"" supported by the sentence: ""Folate is one of the B vitamins which has been suggested to be related to infertility.""?",False, +15826430,Folic Acid related to male infertility,2997,Folate and vitamin B12 in idiopathic male infertility.,"Is the triple ""Folic Acid related to male infertility"" supported by the sentence: ""Folate and vitamin B12 in idiopathic male infertility.""?",False, +14280104,Folic Acid related to myocardial infarction,2998,"CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.","Is the triple ""Folic Acid related to myocardial infarction"" supported by the sentence: ""CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.""?",False, +12974622,Folic Acid related to osteoporosis,2999,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""Folic Acid related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, +12112288,Folic Acid related to autism spectrum disorder,3000,"Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.","Is the triple ""Folic Acid related to autism spectrum disorder"" supported by the sentence: ""Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.""?",False, +11305980,Folic Acid related to cleft palate,3001,"The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.","Is the triple ""Folic Acid related to cleft palate"" supported by the sentence: ""The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.""?",False, +10745702,Folic Acid related to malaria,3002,Administration of pyrimethamine with folic acid and folinic acids in human malaria.,"Is the triple ""Folic Acid related to malaria"" supported by the sentence: ""Administration of pyrimethamine with folic acid and folinic acids in human malaria.""?",False, +10717915,Folic Acid related to habitual spontaneous abortion,3003,SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.,"Is the triple ""Folic Acid related to habitual spontaneous abortion"" supported by the sentence: ""SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.""?",False, +10644755,Folic Acid related to atherosclerosis,3004,[Use of vitamin B12 and folic acid in atherosclerosis].,"Is the triple ""Folic Acid related to atherosclerosis"" supported by the sentence: ""[Use of vitamin B12 and folic acid in atherosclerosis].""?",False, +10226420,Folic Acid related to cervical polyp,3005,"Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.","Is the triple ""Folic Acid related to cervical polyp"" supported by the sentence: ""Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.""?",False, +10177078,Folic Acid related to colorectal neoplasm,3006,CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.,"Is the triple ""Folic Acid related to colorectal neoplasm"" supported by the sentence: ""CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.""?",False, +10046990,Folic Acid related to depressive disorder,3007,This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.,"Is the triple ""Folic Acid related to depressive disorder"" supported by the sentence: ""This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.""?",False, +9815747,Folic Acid related to hypertensive disorder,3008,"In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.","Is the triple ""Folic Acid related to hypertensive disorder"" supported by the sentence: ""In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.""?",False, +9628243,Folic Acid related to mesothelioma,3009,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to mesothelioma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, +9628242,Folic Acid related to non-small cell lung carcinoma,3010,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to non-small cell lung carcinoma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, +9060030,Folic Acid related to neoplasm,3011,Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.,"Is the triple ""Folic Acid related to neoplasm"" supported by the sentence: ""Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.""?",False, +8875457,Folic Acid related to lymphoma,3012,"The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.","Is the triple ""Folic Acid related to lymphoma"" supported by the sentence: ""The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.""?",False, +8584638,Folic Acid related to sickle cell anemia,3013,Erythrocyte folate does not accurately reflect folate status in sickle cell disease.,"Is the triple ""Folic Acid related to sickle cell anemia"" supported by the sentence: ""Erythrocyte folate does not accurately reflect folate status in sickle cell disease.""?",False, +8274471,Folic Acid related to chronic kidney disease,3014,"In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.","Is the triple ""Folic Acid related to chronic kidney disease"" supported by the sentence: ""In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.""?",False, +8259960,Folic Acid related to type 1 diabetes mellitus,3015,"OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.","Is the triple ""Folic Acid related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.""?",False, +8078141,Folic Acid related to Alzheimer disease,3016,Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.,"Is the triple ""Folic Acid related to Alzheimer disease"" supported by the sentence: ""Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.""?",False, +7868306,Folic Acid related to coronary artery disorder,3017,"In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.","Is the triple ""Folic Acid related to coronary artery disorder"" supported by the sentence: ""In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.""?",False, +7765942,Folic Acid related to anemia,3018,"No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.","Is the triple ""Folic Acid related to anemia"" supported by the sentence: ""No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.""?",False, +7303518,Folic Acid related to epilepsy,3019,"Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.","Is the triple ""Folic Acid related to epilepsy"" supported by the sentence: ""Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.""?",False, +7234301,Folic Acid related to Reduced blood folate concentration,3020,Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.,"Is the triple ""Folic Acid related to Reduced blood folate concentration"" supported by the sentence: ""Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.""?",False, +7229825,Folic Acid related to iron deficiency anemia,3021,Status of labile folate in iron deficiency anaemia.,"Is the triple ""Folic Acid related to iron deficiency anemia"" supported by the sentence: ""Status of labile folate in iron deficiency anaemia.""?",False, +7175279,Folic Acid related to rheumatoid arthritis,3022,[Methotrexate and folates in rheumatoid arthritis].,"Is the triple ""Folic Acid related to rheumatoid arthritis"" supported by the sentence: ""[Methotrexate and folates in rheumatoid arthritis].""?",False, +25522909,Folic Acid causes diabetic kidney disease,3023,"The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.","Is the triple ""Folic Acid causes diabetic kidney disease"" supported by the sentence: ""The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.""?",False, +18689556,Folic Acid causes Alzheimer disease,3024,Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.,"Is the triple ""Folic Acid causes Alzheimer disease"" supported by the sentence: ""Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.""?",False, +17559847,Folic Acid causes iron deficiency anemia,3025,"With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).","Is the triple ""Folic Acid causes iron deficiency anemia"" supported by the sentence: ""With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).""?",False, +17044072,Folic Acid causes depressive disorder,3026,The low blood level of folates is the primary cause of depression in Alzheimer's disease.,"Is the triple ""Folic Acid causes depressive disorder"" supported by the sentence: ""The low blood level of folates is the primary cause of depression in Alzheimer's disease.""?",False, +15826434,Folic Acid causes male infertility,3027,This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.,"Is the triple ""Folic Acid causes male infertility"" supported by the sentence: ""This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.""?",False, +15057448,Folic Acid causes chronic kidney disease,3028,"The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.","Is the triple ""Folic Acid causes chronic kidney disease"" supported by the sentence: ""The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.""?",False, +14954987,Folic Acid causes autism spectrum disorder,3029,"Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.","Is the triple ""Folic Acid causes autism spectrum disorder"" supported by the sentence: ""Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.""?",False, +13825749,Folic Acid causes cleft lip,3030,The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).,"Is the triple ""Folic Acid causes cleft lip"" supported by the sentence: ""The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).""?",False, +13656973,Folic Acid causes neoplasm,3031,Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.,"Is the triple ""Folic Acid causes neoplasm"" supported by the sentence: ""Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.""?",False, +12212539,Folic Acid causes lymphoma,3032,"Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.","Is the triple ""Folic Acid causes lymphoma"" supported by the sentence: ""Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.""?",False, +11472417,Folic Acid causes gingival overgrowth,3033,Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.,"Is the triple ""Folic Acid causes gingival overgrowth"" supported by the sentence: ""Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.""?",False, +11073752,Folic Acid causes myocardial ischemia,3034,[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].,"Is the triple ""Folic Acid causes myocardial ischemia"" supported by the sentence: ""[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].""?",False, +10016854,Folic Acid causes hypertensive disorder,3035,"In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.","Is the triple ""Folic Acid causes hypertensive disorder"" supported by the sentence: ""In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.""?",False, +8671948,Folic Acid causes cleft palate,3036,"These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.","Is the triple ""Folic Acid causes cleft palate"" supported by the sentence: ""These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.""?",False, +8640403,Folic Acid causes epilepsy,3037,Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.,"Is the triple ""Folic Acid causes epilepsy"" supported by the sentence: ""Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.""?",False, +7900734,Folic Acid causes coronary artery disorder,3038,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes coronary artery disorder"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, +7900729,Folic Acid causes atherosclerosis,3039,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, +7637475,Folic Acid causes Reduced blood folate concentration,3040,"The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.","Is the triple ""Folic Acid causes Reduced blood folate concentration"" supported by the sentence: ""The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.""?",False, +7460069,Folic Acid causes anemia,3041,"If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.","Is the triple ""Folic Acid causes anemia"" supported by the sentence: ""If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.""?",False, +7392389,Folic Acid causes neural tube defect,3042,The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.,"Is the triple ""Folic Acid causes neural tube defect"" supported by the sentence: ""The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.""?",False, +27400709,Folic Acid affects coronary artery disorder,3043,"Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.","Is the triple ""Folic Acid affects coronary artery disorder"" supported by the sentence: ""Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.""?",False, +27350602,Folic Acid affects cleft palate,3044,"Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.""?",False, +26684582,Folic Acid affects colorectal neoplasm,3045,The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.,"Is the triple ""Folic Acid affects colorectal neoplasm"" supported by the sentence: ""The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.""?",False, +26504524,Folic Acid affects neoplasm,3046,"In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.""?",False, +26433324,Folic Acid affects psychotic disorder,3047,Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.,"Is the triple ""Folic Acid affects psychotic disorder"" supported by the sentence: ""Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.""?",False, +25046427,Folic Acid affects malaria,3048,Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.,"Is the triple ""Folic Acid affects malaria"" supported by the sentence: ""Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.""?",False, +24121807,Folic Acid affects osteoporosis,3049,"However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.","Is the triple ""Folic Acid affects osteoporosis"" supported by the sentence: ""However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.""?",False, +23769753,Folic Acid affects anemia,3050,Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.,"Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.""?",False, +22602503,Folic Acid affects gingival overgrowth,3051,The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.,"Is the triple ""Folic Acid affects gingival overgrowth"" supported by the sentence: ""The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.""?",False, +21177262,Folic Acid affects autism spectrum disorder,3052,The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.,"Is the triple ""Folic Acid affects autism spectrum disorder"" supported by the sentence: ""The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.""?",False, +20060781,Folic Acid affects Hemorrhage,3053,"Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.","Is the triple ""Folic Acid affects Hemorrhage"" supported by the sentence: ""Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.""?",False, +19336710,Folic Acid affects polycystic ovary syndrome,3054,"Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).","Is the triple ""Folic Acid affects polycystic ovary syndrome"" supported by the sentence: ""Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).""?",False, +19172236,Folic Acid affects chronic kidney disease,3055,"Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.","Is the triple ""Folic Acid affects chronic kidney disease"" supported by the sentence: ""Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.""?",False, +19066599,Folic Acid affects Alzheimer disease,3056,"Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.""?",False, +15798837,Folic Acid affects hypertensive disorder,3057,"BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.","Is the triple ""Folic Acid affects hypertensive disorder"" supported by the sentence: ""BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.""?",False, +15143772,Folic Acid affects Reduced blood folate concentration,3058,"However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.""?",False, +14869410,Folic Acid affects epilepsy,3059,It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.,"Is the triple ""Folic Acid affects epilepsy"" supported by the sentence: ""It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.""?",False, +14664528,Folic Acid affects depressive disorder,3060,Our findings that poor folate status may increase depression needs to be further investigated.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Our findings that poor folate status may increase depression needs to be further investigated.""?",False, +14002988,Folic Acid affects depressive disorder,3061,We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.""?",False, +13092563,Folic Acid affects depressive disorder,3062,"Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.","Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.""?",False, +12773835,Folic Acid affects atherosclerosis,3063,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""Folic Acid affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, +11897009,Folic Acid affects Alzheimer disease,3064,"As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.""?",False, +10798682,Folic Acid affects type 2 diabetes mellitus,3065,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""Folic Acid affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, +10733114,Folic Acid affects Reduced blood folate concentration,3066,"Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.""?",False, +10375553,Folic Acid affects neoplasm,3067,"When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.""?",False, +10355008,Folic Acid affects anemia,3068,"The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.","Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.""?",False, +8962241,Folic Acid affects cleft palate,3069,"OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.""?",False, +8101952,Folic Acid affects neural tube defect,3070,"CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.""?",False, +7127212,Folic Acid affects neural tube defect,3071,"To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.""?",False, +19290979,Folic Acid produces neoplasm,3072,"Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.","Is the triple ""Folic Acid produces neoplasm"" supported by the sentence: ""Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.""?",False, +26301481,Folic Acid disrupts epilepsy,3073,A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.,"Is the triple ""Folic Acid disrupts epilepsy"" supported by the sentence: ""A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.""?",False, +22602502,Folic Acid disrupts gingival overgrowth,3074,"Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.","Is the triple ""Folic Acid disrupts gingival overgrowth"" supported by the sentence: ""Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.""?",False, +21452213,Folic Acid disrupts cleft palate,3075,"Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).","Is the triple ""Folic Acid disrupts cleft palate"" supported by the sentence: ""Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).""?",False, +20711939,Folic Acid disrupts autism spectrum disorder,3076,Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.,"Is the triple ""Folic Acid disrupts autism spectrum disorder"" supported by the sentence: ""Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.""?",False, +20091947,Folic Acid disrupts atherosclerosis,3077,"Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.","Is the triple ""Folic Acid disrupts atherosclerosis"" supported by the sentence: ""Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.""?",False, +18758283,Folic Acid disrupts malaria,3078,"Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.","Is the triple ""Folic Acid disrupts malaria"" supported by the sentence: ""Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.""?",False, +18711179,Folic Acid disrupts hypertensive disorder,3079,"Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.","Is the triple ""Folic Acid disrupts hypertensive disorder"" supported by the sentence: ""Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.""?",False, +16597425,Folic Acid disrupts neoplasm,3080,"Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.","Is the triple ""Folic Acid disrupts neoplasm"" supported by the sentence: ""Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.""?",False, +13887579,Folic Acid disrupts anemia,3081,Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.,"Is the triple ""Folic Acid disrupts anemia"" supported by the sentence: ""Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.""?",False, +13415357,Folic Acid disrupts cleft lip,3082,[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].,"Is the triple ""Folic Acid disrupts cleft lip"" supported by the sentence: ""[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].""?",False, +12569851,Folic Acid disrupts HIV infectious disease,3083,"Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.","Is the triple ""Folic Acid disrupts HIV infectious disease"" supported by the sentence: ""Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.""?",False, +11807458,Folic Acid disrupts colorectal neoplasm,3084,Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.,"Is the triple ""Folic Acid disrupts colorectal neoplasm"" supported by the sentence: ""Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.""?",False, +10170875,Folic Acid disrupts depressive disorder,3085,The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.,"Is the triple ""Folic Acid disrupts depressive disorder"" supported by the sentence: ""The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.""?",False, +8333532,Folic Acid disrupts neural tube defect,3086,"Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.","Is the triple ""Folic Acid disrupts neural tube defect"" supported by the sentence: ""Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.""?",False, +8088152,Folic Acid disrupts Reduced blood folate concentration,3087,"We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.","Is the triple ""Folic Acid disrupts Reduced blood folate concentration"" supported by the sentence: ""We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.""?",False, +7255352,Folic Acid disrupts coronary artery disorder,3088,Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.,"Is the triple ""Folic Acid disrupts coronary artery disorder"" supported by the sentence: ""Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.""?",False, +24827653,Folic Acid prevents Hemorrhage,3089,"Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.","Is the triple ""Folic Acid prevents Hemorrhage"" supported by the sentence: ""Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.""?",False, +19249670,Folic Acid prevents epilepsy,3090,"The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.","Is the triple ""Folic Acid prevents epilepsy"" supported by the sentence: ""The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.""?",False, +18676969,Folic Acid prevents neoplasm,3091,"Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.","Is the triple ""Folic Acid prevents neoplasm"" supported by the sentence: ""Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.""?",False, +17577921,Folic Acid prevents diabetic kidney disease,3092,Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.,"Is the triple ""Folic Acid prevents diabetic kidney disease"" supported by the sentence: ""Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.""?",False, +16233198,Folic Acid prevents iron deficiency anemia,3093,"UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.","Is the triple ""Folic Acid prevents iron deficiency anemia"" supported by the sentence: ""UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.""?",False, +15458838,Folic Acid prevents myocardial ischemia,3094,"Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.","Is the triple ""Folic Acid prevents myocardial ischemia"" supported by the sentence: ""Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.""?",False, +15385859,Folic Acid prevents depressive disorder,3095,These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.,"Is the triple ""Folic Acid prevents depressive disorder"" supported by the sentence: ""These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.""?",False, +13602735,Folic Acid prevents gingival overgrowth,3096,A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.,"Is the triple ""Folic Acid prevents gingival overgrowth"" supported by the sentence: ""A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.""?",False, +12999215,Folic Acid prevents hypertensive disorder,3097,"Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.","Is the triple ""Folic Acid prevents hypertensive disorder"" supported by the sentence: ""Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.""?",False, +12947495,Folic Acid prevents cleft lip,3098,CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.,"Is the triple ""Folic Acid prevents cleft lip"" supported by the sentence: ""CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.""?",False, +12911127,Folic Acid prevents Alzheimer disease,3099,BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.,"Is the triple ""Folic Acid prevents Alzheimer disease"" supported by the sentence: ""BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.""?",False, +11842763,Folic Acid prevents cervical polyp,3100,"Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.","Is the triple ""Folic Acid prevents cervical polyp"" supported by the sentence: ""Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.""?",False, +10283354,Folic Acid prevents heart disorder,3101,"Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?","Is the triple ""Folic Acid prevents heart disorder"" supported by the sentence: ""Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?""?",False, +10242010,Folic Acid prevents cleft palate,3102,"CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.","Is the triple ""Folic Acid prevents cleft palate"" supported by the sentence: ""CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.""?",False, +9547944,Folic Acid prevents atherosclerosis,3103,CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.,"Is the triple ""Folic Acid prevents atherosclerosis"" supported by the sentence: ""CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.""?",False, +9000016,Folic Acid prevents anemia,3104,OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.,"Is the triple ""Folic Acid prevents anemia"" supported by the sentence: ""OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.""?",False, +8746975,Folic Acid prevents Reduced blood folate concentration,3105,The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.,"Is the triple ""Folic Acid prevents Reduced blood folate concentration"" supported by the sentence: ""The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.""?",False, +8675157,Folic Acid prevents coronary artery disorder,3106,"Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.","Is the triple ""Folic Acid prevents coronary artery disorder"" supported by the sentence: ""Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.""?",False, +8467407,Folic Acid prevents myocardial infarction,3107,"Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.","Is the triple ""Folic Acid prevents myocardial infarction"" supported by the sentence: ""Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.""?",False, +7303516,Folic Acid prevents neural tube defect,3108,She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.,"Is the triple ""Folic Acid prevents neural tube defect"" supported by the sentence: ""She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.""?",False, +23795062,Folic Acid predisposes depressive disorder,3109,A low level of folate is also thought to be a risk for depression in adults.,"Is the triple ""Folic Acid predisposes depressive disorder"" supported by the sentence: ""A low level of folate is also thought to be a risk for depression in adults.""?",False, +20875914,Folic Acid predisposes chronic kidney disease,3110,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""Folic Acid predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, +20436878,Folic Acid predisposes psychotic disorder,3111,"Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.","Is the triple ""Folic Acid predisposes psychotic disorder"" supported by the sentence: ""Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.""?",False, +19071958,Folic Acid predisposes type 1 diabetes mellitus,3112,"The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.","Is the triple ""Folic Acid predisposes type 1 diabetes mellitus"" supported by the sentence: ""The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.""?",False, +18723777,Folic Acid predisposes systemic lupus erythematosus,3113,"CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.","Is the triple ""Folic Acid predisposes systemic lupus erythematosus"" supported by the sentence: ""CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.""?",False, +16571781,Folic Acid predisposes habitual spontaneous abortion,3114,"Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.","Is the triple ""Folic Acid predisposes habitual spontaneous abortion"" supported by the sentence: ""Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.""?",False, +16186991,Folic Acid predisposes Reduced blood folate concentration,3115,"This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.","Is the triple ""Folic Acid predisposes Reduced blood folate concentration"" supported by the sentence: ""This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.""?",False, +15780148,Folic Acid predisposes epilepsy,3116,Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.,"Is the triple ""Folic Acid predisposes epilepsy"" supported by the sentence: ""Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.""?",False, +15351663,Folic Acid predisposes breast neoplasm,3117,Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.,"Is the triple ""Folic Acid predisposes breast neoplasm"" supported by the sentence: ""Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.""?",False, +14681570,Folic Acid predisposes malaria,3118,"Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.","Is the triple ""Folic Acid predisposes malaria"" supported by the sentence: ""Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.""?",False, +13204073,Folic Acid predisposes autism spectrum disorder,3119,"Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.","Is the triple ""Folic Acid predisposes autism spectrum disorder"" supported by the sentence: ""Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.""?",False, +12966788,Folic Acid predisposes cleft palate,3120,"In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.","Is the triple ""Folic Acid predisposes cleft palate"" supported by the sentence: ""In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.""?",False, +12851634,Folic Acid predisposes osteoporosis,3121,"We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.","Is the triple ""Folic Acid predisposes osteoporosis"" supported by the sentence: ""We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.""?",False, +12628867,Folic Acid predisposes neoplasm,3122,"In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.","Is the triple ""Folic Acid predisposes neoplasm"" supported by the sentence: ""In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.""?",False, +11373442,Folic Acid predisposes colorectal neoplasm,3123,Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.,"Is the triple ""Folic Acid predisposes colorectal neoplasm"" supported by the sentence: ""Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.""?",False, +11241979,Folic Acid predisposes hypertensive disorder,3124,"CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.","Is the triple ""Folic Acid predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.""?",False, +9419598,Folic Acid predisposes Alzheimer disease,3125,"Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.","Is the triple ""Folic Acid predisposes Alzheimer disease"" supported by the sentence: ""Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.""?",False, +9024956,Folic Acid predisposes non-small cell lung carcinoma,3126,CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.,"Is the triple ""Folic Acid predisposes non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.""?",False, +8876702,Folic Acid predisposes atherosclerosis,3127,"The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.","Is the triple ""Folic Acid predisposes atherosclerosis"" supported by the sentence: ""The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.""?",False, +8590186,Folic Acid predisposes anemia,3128,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""Folic Acid predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, +8210149,Folic Acid predisposes myocardial ischemia,3129,Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.,"Is the triple ""Folic Acid predisposes myocardial ischemia"" supported by the sentence: ""Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.""?",False, +8202566,Folic Acid predisposes coronary artery disorder,3130,"Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.","Is the triple ""Folic Acid predisposes coronary artery disorder"" supported by the sentence: ""Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.""?",False, +7807562,Folic Acid predisposes myocardial infarction,3131,The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.,"Is the triple ""Folic Acid predisposes myocardial infarction"" supported by the sentence: ""The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.""?",False, +7720012,Phenylbutazone subclass of Oxyphenbutazone,3132,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Phenylbutazone subclass of Oxyphenbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, +26246718,Phenylbutazone related to Oxyphenbutazone,3133,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, +25613560,Phenylbutazone related to Oxyphenbutazone,3134,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, +20340997,Phenylbutazone physically interacts with Oxyphenbutazone,3135,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Phenylbutazone physically interacts with Oxyphenbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, +26417219,"Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",3136,"At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.","Is the triple ""Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine"" supported by the sentence: ""At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.""?",False, +17467114,Phenylbutazone affects rheumatic disorder,3137,[Research on the mechanism of action of phenylbutazone in rheumatic diseases].,"Is the triple ""Phenylbutazone affects rheumatic disorder"" supported by the sentence: ""[Research on the mechanism of action of phenylbutazone in rheumatic diseases].""?",False, +8146434,Phenylbutazone affects Oxyphenbutazone,3138,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Phenylbutazone affects Oxyphenbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, +7720012,Oxyphenbutazone subclass of Phenylbutazone,3139,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Oxyphenbutazone subclass of Phenylbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, +25613560,Oxyphenbutazone related to Phenylbutazone,3140,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, +26246718,Oxyphenbutazone related to Phenylbutazone,3141,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, +20340997,Oxyphenbutazone physically interacts with Phenylbutazone,3142,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Oxyphenbutazone physically interacts with Phenylbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, +8146434,Oxyphenbutazone affects Phenylbutazone,3143,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Oxyphenbutazone affects Phenylbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, +19336632,Etofenamate prevents Arthralgia,3144,The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.,"Is the triple ""Etofenamate prevents Arthralgia"" supported by the sentence: ""The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.""?",False, +11418550,Piroxicam subclass of 5'-Hydroxypiroxicam,3145,"The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.","Is the triple ""Piroxicam subclass of 5'-Hydroxypiroxicam"" supported by the sentence: ""The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.""?",False, +27695181,Piroxicam affects osteoarthritis,3146,Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.,"Is the triple ""Piroxicam affects osteoarthritis"" supported by the sentence: ""Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.""?",False, +24435495,Piroxicam affects Pain,3147,The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.,"Is the triple ""Piroxicam affects Pain"" supported by the sentence: ""The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.""?",False, +18791248,Piroxicam disrupts Pain,3148,Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.,"Is the triple ""Piroxicam disrupts Pain"" supported by the sentence: ""Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.""?",False, +13746683,Piroxicam prevents Myalgia,3149,"We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.","Is the triple ""Piroxicam prevents Myalgia"" supported by the sentence: ""We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.""?",False, +13092622,Piroxicam prevents Pain,3150,"CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.","Is the triple ""Piroxicam prevents Pain"" supported by the sentence: ""CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.""?",False, +9050885,Bufexamac related to rheumatic disorder,3151,[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].,"Is the triple ""Bufexamac related to rheumatic disorder"" supported by the sentence: ""[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].""?",False, +27600921,Mometasone furoate related to psoriasis,3152,[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].,"Is the triple ""Mometasone furoate related to psoriasis"" supported by the sentence: ""[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].""?",False, +26936147,Mometasone furoate related to skin disorder,3153,Mometasone versus betamethasone creams: a trial in dermatoses.,"Is the triple ""Mometasone furoate related to skin disorder"" supported by the sentence: ""Mometasone versus betamethasone creams: a trial in dermatoses.""?",False, +20328277,Mometasone furoate related to obstructive sleep apnea syndrome,3154,"Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.","Is the triple ""Mometasone furoate related to obstructive sleep apnea syndrome"" supported by the sentence: ""Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.""?",False, +20031657,Mometasone furoate related to diffuse alopecia areata,3155,Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.,"Is the triple ""Mometasone furoate related to diffuse alopecia areata"" supported by the sentence: ""Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.""?",False, +18451558,Mometasone furoate related to spinal cord injury,3156,The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).,"Is the triple ""Mometasone furoate related to spinal cord injury"" supported by the sentence: ""The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).""?",False, +15193244,Mometasone furoate related to severe acute respiratory syndrome,3157,CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.,"Is the triple ""Mometasone furoate related to severe acute respiratory syndrome"" supported by the sentence: ""CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.""?",False, +12129006,Mometasone furoate related to asthma,3158,Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.,"Is the triple ""Mometasone furoate related to asthma"" supported by the sentence: ""Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.""?",False, +12122099,Mometasone furoate related to allergic rhinitis,3159,"The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.","Is the triple ""Mometasone furoate related to allergic rhinitis"" supported by the sentence: ""The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.""?",False, +11696210,Mometasone furoate related to chronic obstructive pulmonary disease,3160,Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.,"Is the triple ""Mometasone furoate related to chronic obstructive pulmonary disease"" supported by the sentence: ""Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.""?",False, +10078337,Mometasone furoate related to perennial allergic rhinitis,3161,Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.,"Is the triple ""Mometasone furoate related to perennial allergic rhinitis"" supported by the sentence: ""Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.""?",False, +8366912,Mometasone furoate related to seasonal allergic rhinitis,3162,[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].,"Is the triple ""Mometasone furoate related to seasonal allergic rhinitis"" supported by the sentence: ""[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].""?",False, +15620377,Mometasone furoate affects asthma,3163,"Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).","Is the triple ""Mometasone furoate affects asthma"" supported by the sentence: ""Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).""?",False, +14474022,Mometasone furoate affects Nasal congestion,3164,CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.,"Is the triple ""Mometasone furoate affects Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.""?",False, +8375063,Mometasone furoate affects allergic rhinitis,3165,The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.,"Is the triple ""Mometasone furoate affects allergic rhinitis"" supported by the sentence: ""The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.""?",False, +17026384,Mometasone furoate prevents Nasal congestion,3166,CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.,"Is the triple ""Mometasone furoate prevents Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.""?",False, +15945486,Mometasone furoate prevents nasal cavity polyp,3167,Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.,"Is the triple ""Mometasone furoate prevents nasal cavity polyp"" supported by the sentence: ""Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.""?",False, +10581126,Methimazole related to hyperthyroidism,3168,Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.,"Is the triple ""Methimazole related to hyperthyroidism"" supported by the sentence: ""Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.""?",False, +8213703,Methimazole causes hyperthyroidism,3169,"These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.","Is the triple ""Methimazole causes hyperthyroidism"" supported by the sentence: ""These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.""?",False, +10543639,Methimazole affects hyperthyroidism,3170,Exacerbation of hyperthyroidism by methimazole during iodide therapy.,"Is the triple ""Methimazole affects hyperthyroidism"" supported by the sentence: ""Exacerbation of hyperthyroidism by methimazole during iodide therapy.""?",False, +25010771,Methimazole prevents hyperthyroidism,3171,"Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.","Is the triple ""Methimazole prevents hyperthyroidism"" supported by the sentence: ""Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.""?",False, +24946616,Safinamide physically interacts with Monoamine Oxidase B,3172,"Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.","Is the triple ""Safinamide physically interacts with Monoamine Oxidase B"" supported by the sentence: ""Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.""?",False, +19231919,Safinamide affects Parkinson disease,3173,"The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.","Is the triple ""Safinamide affects Parkinson disease"" supported by the sentence: ""The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.""?",False, +13464423,Safinamide affects Monoamine Oxidase B,3174,"A third agent with MAO-B inhibition properties, safinamide, is in phase III development.","Is the triple ""Safinamide affects Monoamine Oxidase B"" supported by the sentence: ""A third agent with MAO-B inhibition properties, safinamide, is in phase III development.""?",False, +25942595,Furosemide related to nephrotic syndrome,3175,[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].,"Is the triple ""Furosemide related to nephrotic syndrome"" supported by the sentence: ""[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].""?",False, +25824332,Furosemide related to Fibrosis,3176,Spironolactone and frusemide in cirrhosis with ascites.,"Is the triple ""Furosemide related to Fibrosis"" supported by the sentence: ""Spironolactone and frusemide in cirrhosis with ascites.""?",False, +25791999,Furosemide related to cirrhosis of liver,3177,[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].,"Is the triple ""Furosemide related to cirrhosis of liver"" supported by the sentence: ""[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].""?",False, +25414865,Furosemide related to syndromic disease,3178,"In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.","Is the triple ""Furosemide related to syndromic disease"" supported by the sentence: ""In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.""?",False, +24461287,Furosemide related to essential hypertension,3179,Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.,"Is the triple ""Furosemide related to essential hypertension"" supported by the sentence: ""Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.""?",False, +22834232,Furosemide related to type 2 diabetes mellitus,3180,The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.,"Is the triple ""Furosemide related to type 2 diabetes mellitus"" supported by the sentence: ""The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.""?",False, +19148228,Furosemide related to hypertensive disorder,3181,"A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.","Is the triple ""Furosemide related to hypertensive disorder"" supported by the sentence: ""A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.""?",False, +13031496,Furosemide related to acute kidney failure,3182,Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.,"Is the triple ""Furosemide related to acute kidney failure"" supported by the sentence: ""Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.""?",False, +8084093,Furosemide related to kidney failure,3183,"The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.","Is the triple ""Furosemide related to kidney failure"" supported by the sentence: ""The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.""?",False, +27482853,Furosemide causes Edema,3184,In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.,"Is the triple ""Furosemide causes Edema"" supported by the sentence: ""In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.""?",False, +27015887,Furosemide causes diabetes mellitus,3185,Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.,"Is the triple ""Furosemide causes diabetes mellitus"" supported by the sentence: ""Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.""?",False, +25990601,Furosemide causes hypertensive disorder,3186,[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].,"Is the triple ""Furosemide causes hypertensive disorder"" supported by the sentence: ""[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].""?",False, +25918508,Furosemide causes kidney disorder,3187,[Furosemide-induced nephropathy (author's transl)].,"Is the triple ""Furosemide causes kidney disorder"" supported by the sentence: ""[Furosemide-induced nephropathy (author's transl)].""?",False, +20167150,Furosemide causes syndromic disease,3188,"CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.","Is the triple ""Furosemide causes syndromic disease"" supported by the sentence: ""CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.""?",False, +19659078,Furosemide causes kidney failure,3189,"Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).","Is the triple ""Furosemide causes kidney failure"" supported by the sentence: ""Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).""?",False, +11605290,Furosemide causes nephrotic syndrome,3190,"Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.","Is the triple ""Furosemide causes nephrotic syndrome"" supported by the sentence: ""Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.""?",False, +9601857,Furosemide causes acute kidney failure,3191,"Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.","Is the triple ""Furosemide causes acute kidney failure"" supported by the sentence: ""Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.""?",False, +8252635,Furosemide causes Dyspnea,3192,Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.,"Is the triple ""Furosemide causes Dyspnea"" supported by the sentence: ""Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.""?",False, +26185017,Furosemide affects myocardial infarction,3193,Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.,"Is the triple ""Furosemide affects myocardial infarction"" supported by the sentence: ""Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.""?",False, +25909260,Furosemide affects nephrotic syndrome,3194,Plasma volume and effect of high dose frusemide in nephrotic syndrome.,"Is the triple ""Furosemide affects nephrotic syndrome"" supported by the sentence: ""Plasma volume and effect of high dose frusemide in nephrotic syndrome.""?",False, +22504977,Furosemide affects cirrhosis of liver,3195,"Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.","Is the triple ""Furosemide affects cirrhosis of liver"" supported by the sentence: ""Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.""?",False, +17729926,Furosemide affects Edema,3196,"Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.""?",False, +16155102,Furosemide affects kidney disorder,3197,"This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.","Is the triple ""Furosemide affects kidney disorder"" supported by the sentence: ""This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.""?",False, +15732141,Furosemide affects hypertensive disorder,3198,As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.,"Is the triple ""Furosemide affects hypertensive disorder"" supported by the sentence: ""As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.""?",False, +14935630,Furosemide affects kidney failure,3199,"In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.","Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.""?",False, +14887041,Furosemide affects acute kidney failure,3200,CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.""?",False, +14148250,Furosemide affects kidney failure,3201,OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.,"Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.""?",False, +13740455,Furosemide affects Dyspnea,3202,"Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.","Is the triple ""Furosemide affects Dyspnea"" supported by the sentence: ""Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.""?",False, +12836864,Furosemide affects Edema,3203,"BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.""?",False, +10718312,Furosemide affects diabetes mellitus,3204,[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].,"Is the triple ""Furosemide affects diabetes mellitus"" supported by the sentence: ""[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].""?",False, +8299615,Furosemide affects acute kidney failure,3205,Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.""?",False, +27482854,Furosemide disrupts Edema,3206,Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.,"Is the triple ""Furosemide disrupts Edema"" supported by the sentence: ""Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.""?",False, +19844878,Furosemide disrupts Dyspnea,3207,"At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.","Is the triple ""Furosemide disrupts Dyspnea"" supported by the sentence: ""At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.""?",False, +24717003,Furosemide prevents pulmonary edema,3208,"Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.","Is the triple ""Furosemide prevents pulmonary edema"" supported by the sentence: ""Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.""?",False, +22953098,Furosemide prevents Dyspnea,3209,"Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.","Is the triple ""Furosemide prevents Dyspnea"" supported by the sentence: ""Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.""?",False, +21527038,Furosemide prevents schizophrenia,3210,"Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.","Is the triple ""Furosemide prevents schizophrenia"" supported by the sentence: ""Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.""?",False, +20769925,Furosemide prevents bronchopulmonary dysplasia,3211,CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.,"Is the triple ""Furosemide prevents bronchopulmonary dysplasia"" supported by the sentence: ""CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.""?",False, +12415888,Furosemide prevents kidney disorder,3212,The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.,"Is the triple ""Furosemide prevents kidney disorder"" supported by the sentence: ""The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.""?",False, +11075685,Furosemide prevents hypertensive disorder,3213,"The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.","Is the triple ""Furosemide prevents hypertensive disorder"" supported by the sentence: ""The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.""?",False, +9165205,Furosemide prevents Edema,3214,Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.,"Is the triple ""Furosemide prevents Edema"" supported by the sentence: ""Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.""?",False, +8733555,Furosemide prevents syndromic disease,3215,"The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".","Is the triple ""Furosemide prevents syndromic disease"" supported by the sentence: ""The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".""?",False, +7901682,Furosemide prevents kidney failure,3216,"In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.","Is the triple ""Furosemide prevents kidney failure"" supported by the sentence: ""In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.""?",False, +24388792,Furosemide predisposes acute kidney failure,3217,Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?,"Is the triple ""Furosemide predisposes acute kidney failure"" supported by the sentence: ""Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?""?",False, +23800241,Furosemide predisposes myocardial infarction,3218,"METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).","Is the triple ""Furosemide predisposes myocardial infarction"" supported by the sentence: ""METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).""?",False, +21525697,Furosemide predisposes atherosclerosis,3219,"RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).","Is the triple ""Furosemide predisposes atherosclerosis"" supported by the sentence: ""RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).""?",False, +16660855,Furosemide predisposes kidney disorder,3220,"Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).","Is the triple ""Furosemide predisposes kidney disorder"" supported by the sentence: ""Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).""?",False, +19565633,Nabumetone physically interacts with Cyclooxygenase 2,3221,"The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.""?",False, +14176438,Nabumetone physically interacts with Cyclooxygenase 2,3222,"Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.""?",False, +15189827,Nabumetone affects osteoarthritis,3223,Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.,"Is the triple ""Nabumetone affects osteoarthritis"" supported by the sentence: ""Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.""?",False, +9219116,Nabumetone affects Cyclooxygenase 2,3224,"Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.","Is the triple ""Nabumetone affects Cyclooxygenase 2"" supported by the sentence: ""Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.""?",False, +11784119,Selegiline related to Parkinson disease,3225,Long-term experience with selegiline and levodopa in Parkinson's disease.,"Is the triple ""Selegiline related to Parkinson disease"" supported by the sentence: ""Long-term experience with selegiline and levodopa in Parkinson's disease.""?",False, +7091710,Selegiline related to Monoamine Oxidase B,3226,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, +7091710,Selegiline related to Monoamine Oxidase B,3227,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, +26670675,Selegiline coexists with Monoamine Oxidase B,3228,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, +26670675,Selegiline coexists with Monoamine Oxidase B,3229,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, +13016594,Selegiline physically interacts with Monoamine Oxidase B,3230,L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.,"Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.""?",False, +26762387,Selegiline physically interacts with Monoamine Oxidase B,3231,"MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.","Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.""?",False, +27251718,Selegiline causes depressive disorder,3232,These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.,"Is the triple ""Selegiline causes depressive disorder"" supported by the sentence: ""These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.""?",False, +18216942,Selegiline causes Parkinson disease,3233,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Selegiline causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, +8842901,Selegiline affects Parkinson disease,3234,Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.,"Is the triple ""Selegiline affects Parkinson disease"" supported by the sentence: ""Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.""?",False, +7091708,Selegiline affects Monoamine Oxidase B,3235,"In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.","Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.""?",False, +8615177,Selegiline affects Monoamine Oxidase B,3236,MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.,"Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.""?",False, +11022843,Selegiline disrupts Parkinson disease,3237,"Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.","Is the triple ""Selegiline disrupts Parkinson disease"" supported by the sentence: ""Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.""?",False, +8202759,Selegiline prevents depressive disorder,3238,"The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.","Is the triple ""Selegiline prevents depressive disorder"" supported by the sentence: ""The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.""?",False, +7205408,Selegiline prevents Parkinson disease,3239,Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.,"Is the triple ""Selegiline prevents Parkinson disease"" supported by the sentence: ""Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.""?",False, +21543223,Bumetanide causes pervasive developmental disorder,3240,This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.,"Is the triple ""Bumetanide causes pervasive developmental disorder"" supported by the sentence: ""This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.""?",False, +22325231,Bumetanide affects pervasive developmental disorder,3241,"Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).","Is the triple ""Bumetanide affects pervasive developmental disorder"" supported by the sentence: ""Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).""?",False, +20190253,Bumetanide affects autism spectrum disorder,3242,Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.,"Is the triple ""Bumetanide affects autism spectrum disorder"" supported by the sentence: ""Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.""?",False, +16914848,Bumetanide prevents autism spectrum disorder,3243,"UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.","Is the triple ""Bumetanide prevents autism spectrum disorder"" supported by the sentence: ""UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.""?",False, +11943751,D-Glucosamine related to breast neoplasm,3244,Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.,"Is the triple ""D-Glucosamine related to breast neoplasm"" supported by the sentence: ""Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.""?",False, +7809202,D-Glucosamine related to osteoarthritis,3245,Glucosamine in osteoarthritis.,"Is the triple ""D-Glucosamine related to osteoarthritis"" supported by the sentence: ""Glucosamine in osteoarthritis.""?",False, +27619077,D-Glucosamine causes obesity disorder,3246,"Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.","Is the triple ""D-Glucosamine causes obesity disorder"" supported by the sentence: ""Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.""?",False, +18633463,D-Glucosamine causes osteoarthritis,3247,Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.,"Is the triple ""D-Glucosamine causes osteoarthritis"" supported by the sentence: ""Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.""?",False, +9909825,D-Glucosamine affects osteoarthritis,3248,The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.,"Is the triple ""D-Glucosamine affects osteoarthritis"" supported by the sentence: ""The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.""?",False, +8968754,D-Glucosamine affects obesity disorder,3249,Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).,"Is the triple ""D-Glucosamine affects obesity disorder"" supported by the sentence: ""Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).""?",False, +13460623,D-Glucosamine disrupts osteoarthritis,3250,"Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.","Is the triple ""D-Glucosamine disrupts osteoarthritis"" supported by the sentence: ""Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.""?",False, +11817662,D-Glucosamine prevents osteoarthritis,3251,"OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.","Is the triple ""D-Glucosamine prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.""?",False, +25749858,Torsemide causes hypertensive disorder,3252,Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.,"Is the triple ""Torsemide causes hypertensive disorder"" supported by the sentence: ""Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.""?",False, +26478746,Torsemide affects hypertensive disorder,3253,"The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.","Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.""?",False, +13754465,Torsemide affects hypertensive disorder,3254,Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.,"Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.""?",False, +24478260,Leuprorelin related to infertility disorder,3255,Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.,"Is the triple ""Leuprorelin related to infertility disorder"" supported by the sentence: ""Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.""?",False, +22375547,Leuprorelin related to neoplasm,3256,"For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.","Is the triple ""Leuprorelin related to neoplasm"" supported by the sentence: ""For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.""?",False, +17696905,Leuprorelin related to leiomyoma,3257,"Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.","Is the triple ""Leuprorelin related to leiomyoma"" supported by the sentence: ""Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.""?",False, +16368292,Leuprorelin related to prostate cancer,3258,OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.,"Is the triple ""Leuprorelin related to prostate cancer"" supported by the sentence: ""OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.""?",False, +15413679,Leuprorelin related to endometriosis,3259,The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.,"Is the triple ""Leuprorelin related to endometriosis"" supported by the sentence: ""The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.""?",False, +9878755,Leuprorelin causes hypogonadism,3260,"Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.","Is the triple ""Leuprorelin causes hypogonadism"" supported by the sentence: ""Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.""?",False, +7418968,Leuprorelin causes neoplasm,3261,"In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.","Is the triple ""Leuprorelin causes neoplasm"" supported by the sentence: ""In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.""?",False, +27571709,Leuprorelin affects prostate cancer,3262,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, +27571708,Leuprorelin affects endometriosis,3263,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, +26547561,Leuprorelin affects endometriosis,3264,"Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.""?",False, +26152029,Leuprorelin affects prostate cancer,3265,Endocrine and clinical effects of leuprolide in prostatic cancer.,"Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""Endocrine and clinical effects of leuprolide in prostatic cancer.""?",False, +27542556,Leuprorelin prevents neoplasm,3266,In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.,"Is the triple ""Leuprorelin prevents neoplasm"" supported by the sentence: ""In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.""?",False, +12402472,Leuprorelin prevents Pain,3267,"CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.","Is the triple ""Leuprorelin prevents Pain"" supported by the sentence: ""CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.""?",False, +7814590,Sodium Bicarbonate subclass of Electrolytes,3268,"Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.","Is the triple ""Sodium Bicarbonate subclass of Electrolytes"" supported by the sentence: ""Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.""?",False, +26447678,Sodium Bicarbonate related to cystic fibrosis,3269,Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.,"Is the triple ""Sodium Bicarbonate related to cystic fibrosis"" supported by the sentence: ""Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.""?",False, +26270339,Sodium Bicarbonate related to kidney failure,3270,"Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.","Is the triple ""Sodium Bicarbonate related to kidney failure"" supported by the sentence: ""Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.""?",False, +20718850,Sodium Bicarbonate related to acidosis disorder,3271,There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.,"Is the triple ""Sodium Bicarbonate related to acidosis disorder"" supported by the sentence: ""There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.""?",False, +15047625,Sodium Bicarbonate related to Pain,3272,"We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.","Is the triple ""Sodium Bicarbonate related to Pain"" supported by the sentence: ""We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.""?",False, +14688492,Sodium Bicarbonate related to chronic renal failure syndrome,3273,"We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.","Is the triple ""Sodium Bicarbonate related to chronic renal failure syndrome"" supported by the sentence: ""We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.""?",False, +13166244,Sodium Bicarbonate related to kidney disorder,3274,REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.,"Is the triple ""Sodium Bicarbonate related to kidney disorder"" supported by the sentence: ""REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.""?",False, +12100581,Sodium Bicarbonate physically interacts with Electrolytes,3275,"NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.""?",False, +13772853,Sodium Bicarbonate physically interacts with Electrolytes,3276,"Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.""?",False, +27495118,Sodium Bicarbonate causes kidney failure,3277,"In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.","Is the triple ""Sodium Bicarbonate causes kidney failure"" supported by the sentence: ""In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.""?",False, +18327883,Sodium Bicarbonate causes kidney disorder,3278,This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.,"Is the triple ""Sodium Bicarbonate causes kidney disorder"" supported by the sentence: ""This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.""?",False, +14549296,Sodium Bicarbonate causes injury,3279,Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.,"Is the triple ""Sodium Bicarbonate causes injury"" supported by the sentence: ""Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.""?",False, +8914995,Sodium Bicarbonate causes acidosis disorder,3280,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate causes acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, +25712033,Sodium Bicarbonate affects Abnormality of acid-base homeostasis,3281,An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.,"Is the triple ""Sodium Bicarbonate affects Abnormality of acid-base homeostasis"" supported by the sentence: ""An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.""?",False, +18411502,Sodium Bicarbonate affects injury,3282,OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.,"Is the triple ""Sodium Bicarbonate affects injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.""?",False, +17654743,Sodium Bicarbonate affects kidney disorder,3283,"Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.","Is the triple ""Sodium Bicarbonate affects kidney disorder"" supported by the sentence: ""Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.""?",False, +12960490,Sodium Bicarbonate affects Pain,3284,Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.,"Is the triple ""Sodium Bicarbonate affects Pain"" supported by the sentence: ""Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.""?",False, +8914994,Sodium Bicarbonate affects acidosis disorder,3285,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate affects acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, +14651482,Sodium Bicarbonate disrupts acidosis disorder,3286,"The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.","Is the triple ""Sodium Bicarbonate disrupts acidosis disorder"" supported by the sentence: ""The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.""?",False, +21103228,Sodium Bicarbonate prevents acidosis disorder,3287,According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.,"Is the triple ""Sodium Bicarbonate prevents acidosis disorder"" supported by the sentence: ""According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.""?",False, +13938650,Sodium Bicarbonate prevents injury,3288,Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.,"Is the triple ""Sodium Bicarbonate prevents injury"" supported by the sentence: ""Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.""?",False, +11746267,Sodium Bicarbonate prevents kidney failure,3289,"SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.","Is the triple ""Sodium Bicarbonate prevents kidney failure"" supported by the sentence: ""SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.""?",False, +11205688,Sodium Bicarbonate prevents acute kidney failure,3290,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Bicarbonate prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, +11205686,Sodium Bicarbonate prevents kidney disorder,3291,Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.,"Is the triple ""Sodium Bicarbonate prevents kidney disorder"" supported by the sentence: ""Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.""?",False, +14663272,Sodium Bicarbonate predisposes kidney disorder,3292,PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.,"Is the triple ""Sodium Bicarbonate predisposes kidney disorder"" supported by the sentence: ""PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.""?",False, +14542214,Sodium Bicarbonate predisposes injury,3293,"We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.","Is the triple ""Sodium Bicarbonate predisposes injury"" supported by the sentence: ""We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.""?",False, +17530350,Olmesartan medoxomil affects diabetic kidney disease,3294,Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.,"Is the triple ""Olmesartan medoxomil affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.""?",False, +12894557,Olmesartan medoxomil affects atherosclerosis,3295,Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.,"Is the triple ""Olmesartan medoxomil affects atherosclerosis"" supported by the sentence: ""Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.""?",False, +12254737,Olmesartan medoxomil affects diabetes mellitus,3296,A further evaluation of the effects of OM in diabetes is warranted.,"Is the triple ""Olmesartan medoxomil affects diabetes mellitus"" supported by the sentence: ""A further evaluation of the effects of OM in diabetes is warranted.""?",False, +15583038,Olmesartan medoxomil disrupts hypertensive disorder,3297,"Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.","Is the triple ""Olmesartan medoxomil disrupts hypertensive disorder"" supported by the sentence: ""Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.""?",False, +12254736,Olmesartan medoxomil disrupts proteinuria,3298,"These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).","Is the triple ""Olmesartan medoxomil disrupts proteinuria"" supported by the sentence: ""These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).""?",False, +12254735,Olmesartan medoxomil prevents hypertensive disorder,3299,"At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.","Is the triple ""Olmesartan medoxomil prevents hypertensive disorder"" supported by the sentence: ""At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.""?",False, +9359700,Olmesartan medoxomil prevents atherosclerosis,3300,This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.,"Is the triple ""Olmesartan medoxomil prevents atherosclerosis"" supported by the sentence: ""This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.""?",False, +8752749,Candesartan related to essential hypertension,3301,Comparison of candesartan versus enalapril in essential hypertension.,"Is the triple ""Candesartan related to essential hypertension"" supported by the sentence: ""Comparison of candesartan versus enalapril in essential hypertension.""?",False, +20752265,Candesartan causes Cognitive impairment,3302,"Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.","Is the triple ""Candesartan causes Cognitive impairment"" supported by the sentence: ""Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.""?",False, +14838058,Candesartan causes hypertensive disorder,3303,"Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.","Is the triple ""Candesartan causes hypertensive disorder"" supported by the sentence: ""Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.""?",False, +20512666,Candesartan affects Cognitive impairment,3304,"We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.""?",False, +20051167,Candesartan affects hypertensive disorder,3305,"Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.""?",False, +19501045,Candesartan affects Cognitive impairment,3306,"METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.""?",False, +14118850,Candesartan affects Left ventricular hypertrophy,3307,"The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.","Is the triple ""Candesartan affects Left ventricular hypertrophy"" supported by the sentence: ""The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.""?",False, +9919312,Candesartan affects hypertensive disorder,3308,"RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).""?",False, +14542524,Candesartan disrupts Left ventricular hypertrophy,3309,"A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.","Is the triple ""Candesartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.""?",False, +9479295,Candesartan disrupts hypertensive disorder,3310,Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.,"Is the triple ""Candesartan disrupts hypertensive disorder"" supported by the sentence: ""Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.""?",False, +24756017,Candesartan prevents Cognitive impairment,3311,"Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.","Is the triple ""Candesartan prevents Cognitive impairment"" supported by the sentence: ""Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.""?",False, +15502429,Candesartan prevents cardiovascular disorder,3312,"The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).","Is the triple ""Candesartan prevents cardiovascular disorder"" supported by the sentence: ""The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).""?",False, +12994289,Candesartan prevents Left ventricular hypertrophy,3313,"Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.","Is the triple ""Candesartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.""?",False, +12444324,Candesartan prevents atrial fibrillation,3314,"CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.","Is the triple ""Candesartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.""?",False, +12421723,Candesartan prevents migraine disorder,3315,"CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.","Is the triple ""Candesartan prevents migraine disorder"" supported by the sentence: ""CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.""?",False, +8787605,Candesartan prevents hypertensive disorder,3316,"When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.","Is the triple ""Candesartan prevents hypertensive disorder"" supported by the sentence: ""When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.""?",False, +9420113,Telmisartan related to diabetes mellitus,3317,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to diabetes mellitus"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, +9420112,Telmisartan related to hypertensive disorder,3318,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to hypertensive disorder"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, +16669618,Telmisartan causes cardiovascular disorder,3319,These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.,"Is the triple ""Telmisartan causes cardiovascular disorder"" supported by the sentence: ""These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.""?",False, +16637024,Telmisartan causes hypertensive disorder,3320,Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.,"Is the triple ""Telmisartan causes hypertensive disorder"" supported by the sentence: ""Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.""?",False, +16559226,Telmisartan causes myocardial infarction,3321,"Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.","Is the triple ""Telmisartan causes myocardial infarction"" supported by the sentence: ""Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.""?",False, +14418892,Telmisartan causes Albuminuria,3322,CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.,"Is the triple ""Telmisartan causes Albuminuria"" supported by the sentence: ""CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.""?",False, +13301662,Telmisartan causes diabetes mellitus,3323,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Telmisartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, +20835589,Telmisartan affects diabetic kidney disease,3324,This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.,"Is the triple ""Telmisartan affects diabetic kidney disease"" supported by the sentence: ""This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.""?",False, +17882285,Telmisartan affects Albuminuria,3325,"Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.""?",False, +16266744,Telmisartan affects Albuminuria,3326,Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.,"Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.""?",False, +15802746,Telmisartan affects diabetes mellitus,3327,"Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.""?",False, +13992848,Telmisartan affects diabetes mellitus,3328,"Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.""?",False, +13861721,Telmisartan affects type 2 diabetes mellitus,3329,Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.,"Is the triple ""Telmisartan affects type 2 diabetes mellitus"" supported by the sentence: ""Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.""?",False, +13824093,Telmisartan affects Albuminuria,3330,"An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.""?",False, +13501012,Telmisartan affects essential hypertension,3331,CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.,"Is the triple ""Telmisartan affects essential hypertension"" supported by the sentence: ""CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.""?",False, +13178302,Telmisartan affects hypertensive disorder,3332,"In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.","Is the triple ""Telmisartan affects hypertensive disorder"" supported by the sentence: ""In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.""?",False, +25051574,Telmisartan disrupts Alzheimer disease,3333,"RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).","Is the triple ""Telmisartan disrupts Alzheimer disease"" supported by the sentence: ""RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).""?",False, +14418891,Telmisartan disrupts Albuminuria,3334,RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.,"Is the triple ""Telmisartan disrupts Albuminuria"" supported by the sentence: ""RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.""?",False, +13325686,Telmisartan disrupts hypertensive disorder,3335,"WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.","Is the triple ""Telmisartan disrupts hypertensive disorder"" supported by the sentence: ""WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.""?",False, +21182197,Telmisartan prevents Alzheimer disease,3336,Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.,"Is the triple ""Telmisartan prevents Alzheimer disease"" supported by the sentence: ""Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.""?",False, +17513403,Telmisartan prevents myocardial infarction,3337,This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.,"Is the triple ""Telmisartan prevents myocardial infarction"" supported by the sentence: ""This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.""?",False, +17170882,Telmisartan prevents type 2 diabetes mellitus,3338,"OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).","Is the triple ""Telmisartan prevents type 2 diabetes mellitus"" supported by the sentence: ""OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).""?",False, +13010398,Telmisartan prevents stroke disorder,3339,"The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.","Is the triple ""Telmisartan prevents stroke disorder"" supported by the sentence: ""The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.""?",False, +12278433,Telmisartan prevents diabetic kidney disease,3340,"In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.","Is the triple ""Telmisartan prevents diabetic kidney disease"" supported by the sentence: ""In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.""?",False, +11585228,Telmisartan prevents diabetes mellitus,3341,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents diabetes mellitus"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, +11585227,Telmisartan prevents cardiovascular disorder,3342,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents cardiovascular disorder"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, +11473935,Telmisartan prevents hypertensive disorder,3343,"In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.","Is the triple ""Telmisartan prevents hypertensive disorder"" supported by the sentence: ""In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.""?",False, +17028323,Telmisartan predisposes stroke disorder,3344,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes stroke disorder"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, +17028322,Telmisartan predisposes myocardial infarction,3345,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes myocardial infarction"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, +21651336,Irbesartan causes hypertensive disorder,3346,"The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.","Is the triple ""Irbesartan causes hypertensive disorder"" supported by the sentence: ""The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.""?",False, +19454247,Irbesartan affects Sepsis,3347,Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.,"Is the triple ""Irbesartan affects Sepsis"" supported by the sentence: ""Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.""?",False, +13143483,Irbesartan affects type 2 diabetes mellitus,3348,CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.,"Is the triple ""Irbesartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.""?",False, +9015828,Irbesartan affects chronic kidney disease,3349,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects chronic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, +9015827,Irbesartan affects diabetic kidney disease,3350,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects diabetic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, +7812861,Irbesartan affects acute kidney failure,3351,[Acute renal failure associated with irbesartan].,"Is the triple ""Irbesartan affects acute kidney failure"" supported by the sentence: ""[Acute renal failure associated with irbesartan].""?",False, +19016605,Irbesartan disrupts atrial fibrillation,3352,Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.,"Is the triple ""Irbesartan disrupts atrial fibrillation"" supported by the sentence: ""Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.""?",False, +11936096,Irbesartan disrupts hypertensive disorder,3353,"Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.","Is the triple ""Irbesartan disrupts hypertensive disorder"" supported by the sentence: ""Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.""?",False, +9297339,Irbesartan disrupts diabetic kidney disease,3354,Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.,"Is the triple ""Irbesartan disrupts diabetic kidney disease"" supported by the sentence: ""Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.""?",False, +11467158,Irbesartan prevents chronic kidney disease,3355,"In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.","Is the triple ""Irbesartan prevents chronic kidney disease"" supported by the sentence: ""In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.""?",False, +9856662,Irbesartan prevents diabetic kidney disease,3356,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Irbesartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, +8753962,Irbesartan prevents hypertensive disorder,3357,Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.,"Is the triple ""Irbesartan prevents hypertensive disorder"" supported by the sentence: ""Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.""?",False, +15497727,Irbesartan predisposes cardiovascular disorder,3358,"PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.","Is the triple ""Irbesartan predisposes cardiovascular disorder"" supported by the sentence: ""PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.""?",False, +12041301,Irbesartan predisposes IgA glomerulonephritis,3359,OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.,"Is the triple ""Irbesartan predisposes IgA glomerulonephritis"" supported by the sentence: ""OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.""?",False, +9459261,Eprosartan related to essential hypertension,3360,Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.,"Is the triple ""Eprosartan related to essential hypertension"" supported by the sentence: ""Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.""?",False, +8111433,Valsartan related to essential hypertension,3361,"While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.","Is the triple ""Valsartan related to essential hypertension"" supported by the sentence: ""While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.""?",False, +18505936,Valsartan causes myocardial infarction,3362,Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.,"Is the triple ""Valsartan causes myocardial infarction"" supported by the sentence: ""Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.""?",False, +13301661,Valsartan causes diabetes mellitus,3363,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Valsartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, +18533693,Valsartan affects hypertensive disorder,3364,"TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.","Is the triple ""Valsartan affects hypertensive disorder"" supported by the sentence: ""TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.""?",False, +18130226,Valsartan affects stroke disorder,3365,"We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.","Is the triple ""Valsartan affects stroke disorder"" supported by the sentence: ""We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.""?",False, +16609149,Valsartan affects kidney disorder,3366,"This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.","Is the triple ""Valsartan affects kidney disorder"" supported by the sentence: ""This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.""?",False, +9837968,Valsartan affects Abnormal left ventricular function,3367,Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.,"Is the triple ""Valsartan affects Abnormal left ventricular function"" supported by the sentence: ""Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.""?",False, +15479686,Valsartan disrupts type 2 diabetes mellitus,3368,These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.,"Is the triple ""Valsartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.""?",False, +11438135,Valsartan disrupts atherosclerosis,3369,"Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.","Is the triple ""Valsartan disrupts atherosclerosis"" supported by the sentence: ""Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.""?",False, +20671333,Valsartan prevents Abnormal left ventricular function,3370,"CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.","Is the triple ""Valsartan prevents Abnormal left ventricular function"" supported by the sentence: ""CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.""?",False, +15012324,Valsartan prevents type 2 diabetes mellitus,3371,"In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.","Is the triple ""Valsartan prevents type 2 diabetes mellitus"" supported by the sentence: ""In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.""?",False, +13899819,Valsartan prevents stroke disorder,3372,"Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.","Is the triple ""Valsartan prevents stroke disorder"" supported by the sentence: ""Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.""?",False, +12374506,Valsartan prevents diabetes mellitus,3373,"Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.","Is the triple ""Valsartan prevents diabetes mellitus"" supported by the sentence: ""Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.""?",False, +12038680,Valsartan prevents myocardial infarction,3374,"For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.","Is the triple ""Valsartan prevents myocardial infarction"" supported by the sentence: ""For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.""?",False, +11801448,Valsartan prevents atrial fibrillation,3375,CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.,"Is the triple ""Valsartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.""?",False, +8617185,Valsartan prevents coronary artery disorder,3376,"Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.","Is the triple ""Valsartan prevents coronary artery disorder"" supported by the sentence: ""Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.""?",False, +7691192,Valsartan prevents hypertensive disorder,3377,"Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.","Is the triple ""Valsartan prevents hypertensive disorder"" supported by the sentence: ""Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.""?",False, +7604460,Valsartan prevents atherosclerosis,3378,CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.,"Is the triple ""Valsartan prevents atherosclerosis"" supported by the sentence: ""CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.""?",False, +21524148,Valsartan predisposes myocardial infarction,3379,"Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).","Is the triple ""Valsartan predisposes myocardial infarction"" supported by the sentence: ""Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).""?",False, +11133518,Valsartan predisposes cardiovascular disorder,3380,"Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.","Is the triple ""Valsartan predisposes cardiovascular disorder"" supported by the sentence: ""Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.""?",False, +13065808,Losartan related to non-alcoholic fatty liver disease,3381,"AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.","Is the triple ""Losartan related to non-alcoholic fatty liver disease"" supported by the sentence: ""AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.""?",False, +12094342,Losartan related to proteinuria,3382,"The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.","Is the triple ""Losartan related to proteinuria"" supported by the sentence: ""The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.""?",False, +11472713,Losartan related to kidney disorder,3383,Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.,"Is the triple ""Losartan related to kidney disorder"" supported by the sentence: ""Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.""?",False, +10013644,Losartan related to hypertensive disorder,3384,"OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.","Is the triple ""Losartan related to hypertensive disorder"" supported by the sentence: ""OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.""?",False, +8975375,Losartan related to IgA glomerulonephritis,3385,Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.,"Is the triple ""Losartan related to IgA glomerulonephritis"" supported by the sentence: ""Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.""?",False, +16215194,Losartan causes injury,3386,"METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.","Is the triple ""Losartan causes injury"" supported by the sentence: ""METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.""?",False, +15690681,Losartan causes kidney disorder,3387,"Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.","Is the triple ""Losartan causes kidney disorder"" supported by the sentence: ""Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.""?",False, +9749061,Losartan causes hypertensive disorder,3388,Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.,"Is the triple ""Losartan causes hypertensive disorder"" supported by the sentence: ""Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.""?",False, +7310301,Losartan causes proteinuria,3389,"In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.","Is the triple ""Losartan causes proteinuria"" supported by the sentence: ""In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.""?",False, +7204638,Losartan causes Left ventricular hypertrophy,3390,The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.,"Is the triple ""Losartan causes Left ventricular hypertrophy"" supported by the sentence: ""The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.""?",False, +26608778,Losartan affects essential hypertension,3391,The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.,"Is the triple ""Losartan affects essential hypertension"" supported by the sentence: ""The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.""?",False, +24425437,Losartan affects cystic fibrosis,3392,Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.,"Is the triple ""Losartan affects cystic fibrosis"" supported by the sentence: ""Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.""?",False, +21888728,Losartan affects proteinuria,3393,"Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.""?",False, +20488125,Losartan affects hypertensive disorder,3394,"The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.","Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.""?",False, +19990804,Losartan affects aortic valve insufficiency,3395,Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.,"Is the triple ""Losartan affects aortic valve insufficiency"" supported by the sentence: ""Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.""?",False, +18707849,Losartan affects hypertrophic cardiomyopathy,3396,Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.,"Is the triple ""Losartan affects hypertrophic cardiomyopathy"" supported by the sentence: ""Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.""?",False, +16976701,Losartan affects IgA glomerulonephritis,3397,CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.,"Is the triple ""Losartan affects IgA glomerulonephritis"" supported by the sentence: ""CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.""?",False, +13986638,Losartan affects adult acute respiratory distress syndrome,3398,This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.,"Is the triple ""Losartan affects adult acute respiratory distress syndrome"" supported by the sentence: ""This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.""?",False, +13539739,Losartan affects proteinuria,3399,"Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.""?",False, +13498248,Losartan affects Inflammation,3400,"Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.","Is the triple ""Losartan affects Inflammation"" supported by the sentence: ""Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.""?",False, +12531070,Losartan affects Left ventricular hypertrophy,3401,Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.,"Is the triple ""Losartan affects Left ventricular hypertrophy"" supported by the sentence: ""Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.""?",False, +10809955,Losartan affects hypertensive disorder,3402,Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).,"Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).""?",False, +9615315,Losartan affects diabetic kidney disease,3403,Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?,"Is the triple ""Losartan affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?""?",False, +9459571,Losartan affects type 2 diabetes mellitus,3404,CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.""?",False, +9229634,Losartan affects kidney disorder,3405,Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.,"Is the triple ""Losartan affects kidney disorder"" supported by the sentence: ""Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.""?",False, +8678480,Losartan affects injury,3406,"Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.","Is the triple ""Losartan affects injury"" supported by the sentence: ""Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.""?",False, +8551167,Losartan affects type 2 diabetes mellitus,3407,METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.""?",False, +18715311,Losartan disrupts breast neoplasm,3408,"In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.","Is the triple ""Losartan disrupts breast neoplasm"" supported by the sentence: ""In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.""?",False, +14458903,Losartan disrupts pancreatic neoplasm,3409,"When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.","Is the triple ""Losartan disrupts pancreatic neoplasm"" supported by the sentence: ""When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.""?",False, +13976332,Losartan disrupts diabetic kidney disease,3410,OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.,"Is the triple ""Losartan disrupts diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.""?",False, +12949848,Losartan disrupts Inflammation,3411,"Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.","Is the triple ""Losartan disrupts Inflammation"" supported by the sentence: ""Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.""?",False, +9870082,Losartan disrupts hypertensive disorder,3412,Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).,"Is the triple ""Losartan disrupts hypertensive disorder"" supported by the sentence: ""Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).""?",False, +9655766,Losartan disrupts type 2 diabetes mellitus,3413,"Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.","Is the triple ""Losartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.""?",False, +8325352,Losartan disrupts Left ventricular hypertrophy,3414,"Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.","Is the triple ""Losartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.""?",False, +7975855,Losartan disrupts injury,3415,Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.,"Is the triple ""Losartan disrupts injury"" supported by the sentence: ""Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.""?",False, +7310299,Losartan disrupts proteinuria,3416,"CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.","Is the triple ""Losartan disrupts proteinuria"" supported by the sentence: ""CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.""?",False, +21356716,Losartan prevents post-traumatic stress disorder,3417,"We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.","Is the triple ""Losartan prevents post-traumatic stress disorder"" supported by the sentence: ""We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.""?",False, +14540327,Losartan prevents kidney disorder,3418,BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.,"Is the triple ""Losartan prevents kidney disorder"" supported by the sentence: ""BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.""?",False, +12407992,Losartan prevents Inflammation,3419,"RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.","Is the triple ""Losartan prevents Inflammation"" supported by the sentence: ""RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.""?",False, +10030687,Losartan prevents cardiovascular disorder,3420,Losartan vs atenolol in prevention of stroke and cardiovascular disease.,"Is the triple ""Losartan prevents cardiovascular disorder"" supported by the sentence: ""Losartan vs atenolol in prevention of stroke and cardiovascular disease.""?",False, +9856661,Losartan prevents diabetic kidney disease,3421,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Losartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, +9773800,Losartan prevents Left ventricular hypertrophy,3422,Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.,"Is the triple ""Losartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.""?",False, +9766007,Losartan prevents adult acute respiratory distress syndrome,3423,"Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.","Is the triple ""Losartan prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.""?",False, +9420091,Losartan prevents Stenosis,3424,The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.,"Is the triple ""Losartan prevents Stenosis"" supported by the sentence: ""The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.""?",False, +9077908,Losartan prevents proteinuria,3425,"Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.","Is the triple ""Losartan prevents proteinuria"" supported by the sentence: ""Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.""?",False, +8542944,Losartan prevents injury,3426,Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.,"Is the triple ""Losartan prevents injury"" supported by the sentence: ""Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.""?",False, +7768196,Losartan prevents hypertensive disorder,3427,"RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.","Is the triple ""Losartan prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.""?",False, +14272023,Losartan predisposes kidney disorder,3428,"Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.","Is the triple ""Losartan predisposes kidney disorder"" supported by the sentence: ""Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.""?",False, +12616336,Losartan predisposes cardiovascular disorder,3429,"Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.","Is the triple ""Losartan predisposes cardiovascular disorder"" supported by the sentence: ""Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.""?",False, +9964252,Losartan predisposes Left ventricular hypertrophy,3430,"In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).","Is the triple ""Losartan predisposes Left ventricular hypertrophy"" supported by the sentence: ""In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).""?",False, +20586471,Dronabinol related to multiple sclerosis,3431,A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.,"Is the triple ""Dronabinol related to multiple sclerosis"" supported by the sentence: ""A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.""?",False, +25459397,Dronabinol causes cannabis dependence,3432,"BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.","Is the triple ""Dronabinol causes cannabis dependence"" supported by the sentence: ""BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.""?",False, +22027243,Dronabinol causes Nausea,3433,"CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.","Is the triple ""Dronabinol causes Nausea"" supported by the sentence: ""CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.""?",False, +17252204,Dronabinol causes schizophrenia,3434,"Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.","Is the triple ""Dronabinol causes schizophrenia"" supported by the sentence: ""Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.""?",False, +12205989,Dronabinol causes Cognitive impairment,3435,"Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.","Is the triple ""Dronabinol causes Cognitive impairment"" supported by the sentence: ""Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.""?",False, +27448088,Dronabinol affects Anorexia,3436,Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.,"Is the triple ""Dronabinol affects Anorexia"" supported by the sentence: ""Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.""?",False, +25890458,Dronabinol affects Nausea,3437,"Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.","Is the triple ""Dronabinol affects Nausea"" supported by the sentence: ""Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.""?",False, +21879717,Dronabinol affects anorexia nervosa,3438,"The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.","Is the triple ""Dronabinol affects anorexia nervosa"" supported by the sentence: ""The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.""?",False, +20855895,Dronabinol affects neoplasm,3439,"Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.","Is the triple ""Dronabinol affects neoplasm"" supported by the sentence: ""Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.""?",False, +19991701,Dronabinol affects obstructive sleep apnea syndrome,3440,"Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.","Is the triple ""Dronabinol affects obstructive sleep apnea syndrome"" supported by the sentence: ""Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.""?",False, +19474044,Dronabinol affects multiple sclerosis,3441,Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.,"Is the triple ""Dronabinol affects multiple sclerosis"" supported by the sentence: ""Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.""?",False, +16547908,Dronabinol affects schizophrenia,3442,"CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.""?",False, +14443952,Dronabinol affects opiate dependence,3443,Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.,"Is the triple ""Dronabinol affects opiate dependence"" supported by the sentence: ""Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.""?",False, +13958866,Dronabinol affects Cognitive impairment,3444,"Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.","Is the triple ""Dronabinol affects Cognitive impairment"" supported by the sentence: ""Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.""?",False, +13933776,Dronabinol affects schizophrenia,3445,"This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.""?",False, +11304843,Dronabinol affects neuralgia,3446,OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.,"Is the triple ""Dronabinol affects neuralgia"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.""?",False, +11058493,Dronabinol affects Pain,3447,"THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.","Is the triple ""Dronabinol affects Pain"" supported by the sentence: ""THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.""?",False, +24013541,Dronabinol disrupts Pain,3448,"Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.","Is the triple ""Dronabinol disrupts Pain"" supported by the sentence: ""Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.""?",False, +17477155,Dronabinol disrupts HIV infectious disease,3449,"Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.","Is the triple ""Dronabinol disrupts HIV infectious disease"" supported by the sentence: ""Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.""?",False, +11615857,Dronabinol disrupts Nausea,3450,"The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.","Is the triple ""Dronabinol disrupts Nausea"" supported by the sentence: ""The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.""?",False, +25196408,Dronabinol prevents dementia,3451,Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.,"Is the triple ""Dronabinol prevents dementia"" supported by the sentence: ""Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.""?",False, +25026370,Dronabinol prevents neuralgia,3452,We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.,"Is the triple ""Dronabinol prevents neuralgia"" supported by the sentence: ""We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.""?",False, +18579580,Dronabinol prevents Postoperative Nausea and Vomiting,3453,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, +18554637,Dronabinol prevents Nausea,3454,"However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.","Is the triple ""Dronabinol prevents Nausea"" supported by the sentence: ""However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.""?",False, +17477149,Dronabinol prevents HIV infectious disease,3455,THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.,"Is the triple ""Dronabinol prevents HIV infectious disease"" supported by the sentence: ""THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.""?",False, +9671016,Dronabinol prevents Pain,3456,"There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.","Is the triple ""Dronabinol prevents Pain"" supported by the sentence: ""There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.""?",False, +22976957,Dronabinol predisposes Cognitive impairment,3457,"The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.","Is the triple ""Dronabinol predisposes Cognitive impairment"" supported by the sentence: ""The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.""?",False, +18579581,Dronabinol predisposes Postoperative Nausea and Vomiting,3458,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol predisposes Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, +26722658,Cesamet affects Postoperative Nausea and Vomiting,3459,"In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).","Is the triple ""Cesamet affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).""?",False, +26699974,Cesamet affects Nausea,3460,Effect of nabilone on nausea and vomiting.,"Is the triple ""Cesamet affects Nausea"" supported by the sentence: ""Effect of nabilone on nausea and vomiting.""?",False, +19460580,Cesamet prevents Postoperative Nausea and Vomiting,3461,METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.,"Is the triple ""Cesamet prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.""?",False, +25552574,Aprepitant related to glioblastoma,3462,"The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.","Is the triple ""Aprepitant related to glioblastoma"" supported by the sentence: ""The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.""?",False, +18054447,Aprepitant related to Vomiting,3463,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Vomiting"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, +18054446,Aprepitant related to Nausea,3464,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Nausea"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, +11788538,Aprepitant causes Vomiting,3465,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Vomiting"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, +11788537,Aprepitant causes Nausea,3466,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Nausea"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, +23692862,Aprepitant affects Nausea,3467,"The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.","Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.""?",False, +19750085,Aprepitant affects Postoperative Nausea and Vomiting,3468,"In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.","Is the triple ""Aprepitant affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.""?",False, +17874842,Aprepitant affects Vomiting,3469,"Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.","Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.""?",False, +12562288,Aprepitant affects Nausea,3470,Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.,"Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.""?",False, +11119543,Aprepitant affects Vomiting,3471,Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.,"Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.""?",False, +19013645,Aprepitant disrupts HIV infectious disease,3472,RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.,"Is the triple ""Aprepitant disrupts HIV infectious disease"" supported by the sentence: ""RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.""?",False, +16125731,Aprepitant disrupts Vomiting,3473,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Vomiting"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, +16125730,Aprepitant disrupts Nausea,3474,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Nausea"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, +16513148,Aprepitant prevents Pruritus,3475,"INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.","Is the triple ""Aprepitant prevents Pruritus"" supported by the sentence: ""INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.""?",False, +15868137,Aprepitant prevents Postoperative Nausea and Vomiting,3476,We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.,"Is the triple ""Aprepitant prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.""?",False, +10160541,Aprepitant prevents Vomiting,3477,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Vomiting"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, +10160540,Aprepitant prevents Nausea,3478,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Nausea"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, +20804596,Aprepitant predisposes Nausea,3479,"CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.","Is the triple ""Aprepitant predisposes Nausea"" supported by the sentence: ""CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.""?",False, +22122089,Neratinib affects neoplasm,3480,The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].,"Is the triple ""Neratinib affects neoplasm"" supported by the sentence: ""The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].""?",False, +21597229,Lapatinib related to neoplasm,3481,"Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.","Is the triple ""Lapatinib related to neoplasm"" supported by the sentence: ""Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.""?",False, +13650844,Lapatinib related to non-small cell lung carcinoma,3482,"In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.","Is the triple ""Lapatinib related to non-small cell lung carcinoma"" supported by the sentence: ""In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.""?",False, +18268107,Lapatinib affects neoplasm,3483,Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.,"Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.""?",False, +15442238,Lapatinib affects breast neoplasm,3484,HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.,"Is the triple ""Lapatinib affects breast neoplasm"" supported by the sentence: ""HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.""?",False, +14691634,Lapatinib affects neoplasm,3485,"However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.","Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.""?",False, +17546445,Lapatinib disrupts neoplasm,3486,"Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.","Is the triple ""Lapatinib disrupts neoplasm"" supported by the sentence: ""Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.""?",False, +19410918,Lapatinib prevents breast neoplasm,3487,"Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.","Is the triple ""Lapatinib prevents breast neoplasm"" supported by the sentence: ""Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.""?",False, +19317295,Lapatinib prevents neoplasm,3488,CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.,"Is the triple ""Lapatinib prevents neoplasm"" supported by the sentence: ""CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.""?",False, +16643911,Lapatinib predisposes neoplasm,3489,"We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.","Is the triple ""Lapatinib predisposes neoplasm"" supported by the sentence: ""We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.""?",False, +24360220,Nifurtimox related to human African trypanosomiasis,3490,Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.,"Is the triple ""Nifurtimox related to human African trypanosomiasis"" supported by the sentence: ""Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.""?",False, +25977066,Nifurtimox coexists with Deoxyribonucleic acid,3491,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, +25977066,Nifurtimox coexists with Deoxyribonucleic acid,3492,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, +25822629,Nifurtimox causes Chagas disease,3493,Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.,"Is the triple ""Nifurtimox causes Chagas disease"" supported by the sentence: ""Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.""?",False, +21140520,Nifurtimox affects neuroblastoma,3494,"Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.","Is the triple ""Nifurtimox affects neuroblastoma"" supported by the sentence: ""Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.""?",False, +19390598,Nifurtimox affects trypanosomiasis,3495,"The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.","Is the triple ""Nifurtimox affects trypanosomiasis"" supported by the sentence: ""The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.""?",False, +18236131,Nifurtimox affects Deoxyribonucleic acid,3496,"Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).","Is the triple ""Nifurtimox affects Deoxyribonucleic acid"" supported by the sentence: ""Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).""?",False, +21140519,Nifurtimox disrupts neuroblastoma,3497,"Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.","Is the triple ""Nifurtimox disrupts neuroblastoma"" supported by the sentence: ""Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.""?",False, +16729888,Nifurtimox prevents Chagas disease,3498,"Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.","Is the triple ""Nifurtimox prevents Chagas disease"" supported by the sentence: ""Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.""?",False, +8359719,Nitrofurazone coexists with Deoxyribonucleic acid,3499,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, +8359719,Nitrofurazone coexists with Deoxyribonucleic acid,3500,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, +21506050,Nitrofurazone physically interacts with Deoxyribonucleic acid,3501,"Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.""?",False, +16350865,Nitrofurazone physically interacts with Deoxyribonucleic acid,3502,"In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.""?",False, +26982963,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3503,The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.""?",False, +14891197,SCOPOLAMINE HYDROBROMIDE affects Pain,3504,Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Pain"" supported by the sentence: ""Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.""?",False, +13216168,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3505,The effects of scopolamine on MS were studied in mice and rats.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The effects of scopolamine on MS were studied in mice and rats.""?",False, +9844335,SCOPOLAMINE HYDROBROMIDE affects Drooling,3506,"CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.","Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Drooling"" supported by the sentence: ""CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.""?",False, +11447618,SCOPOLAMINE HYDROBROMIDE prevents Pain,3507,In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Pain"" supported by the sentence: ""In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.""?",False, +11253841,SCOPOLAMINE HYDROBROMIDE prevents Drooling,3508,"Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.","Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Drooling"" supported by the sentence: ""Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.""?",False, +8806634,SCOPOLAMINE HYDROBROMIDE prevents motion sickness,3509,Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents motion sickness"" supported by the sentence: ""Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.""?",False, +26997768,Metopimazine affects Nausea,3510,"RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.","Is the triple ""Metopimazine affects Nausea"" supported by the sentence: ""RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.""?",False, +12265728,Metopimazine prevents Nausea,3511,"This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.","Is the triple ""Metopimazine prevents Nausea"" supported by the sentence: ""This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.""?",False, +27200379,Lincomycin related to osteomyelitis,3512,[Optimal regime of intravenous administration of lincomycin in osteomyelitis].,"Is the triple ""Lincomycin related to osteomyelitis"" supported by the sentence: ""[Optimal regime of intravenous administration of lincomycin in osteomyelitis].""?",False, +9905527,Sulindac causes classic familial adenomatous polyposis,3513,"CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.","Is the triple ""Sulindac causes classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.""?",False, +9905522,Sulindac affects classic familial adenomatous polyposis,3514,Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.""?",False, +8547552,Sulindac affects classic familial adenomatous polyposis,3515,CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.""?",False, +11060423,Sulindac prevents classic familial adenomatous polyposis,3516,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Sulindac prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, +20876966,Ketorolac related to migraine disorder,3517,"Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.","Is the triple ""Ketorolac related to migraine disorder"" supported by the sentence: ""Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.""?",False, +27688883,Ketorolac causes Inflammation,3518,We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.,"Is the triple ""Ketorolac causes Inflammation"" supported by the sentence: ""We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.""?",False, +21368479,Ketorolac causes pancreatitis,3519,Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.,"Is the triple ""Ketorolac causes pancreatitis"" supported by the sentence: ""Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.""?",False, +19597016,Ketorolac causes Miosis,3520,CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.,"Is the triple ""Ketorolac causes Miosis"" supported by the sentence: ""CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.""?",False, +12090892,Ketorolac causes Pain,3521,"However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.","Is the triple ""Ketorolac causes Pain"" supported by the sentence: ""However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.""?",False, +20018980,Ketorolac affects breast neoplasm,3522,The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.,"Is the triple ""Ketorolac affects breast neoplasm"" supported by the sentence: ""The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.""?",False, +19245410,Ketorolac affects Miosis,3523,"Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.","Is the triple ""Ketorolac affects Miosis"" supported by the sentence: ""Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.""?",False, +9719257,Ketorolac affects Pain,3524,Effect of pretreatment with ketorolac on propofol injection pain.,"Is the triple ""Ketorolac affects Pain"" supported by the sentence: ""Effect of pretreatment with ketorolac on propofol injection pain.""?",False, +24071071,Ketorolac disrupts Headache,3525,CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.,"Is the triple ""Ketorolac disrupts Headache"" supported by the sentence: ""CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.""?",False, +24029444,Ketorolac disrupts Inflammation,3526,"Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.","Is the triple ""Ketorolac disrupts Inflammation"" supported by the sentence: ""Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.""?",False, +11549492,Ketorolac disrupts Pain,3527,Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.,"Is the triple ""Ketorolac disrupts Pain"" supported by the sentence: ""Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.""?",False, +11362008,Ketorolac disrupts Back pain,3528,"Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.","Is the triple ""Ketorolac disrupts Back pain"" supported by the sentence: ""Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.""?",False, +24306825,Ketorolac prevents Renal Colic,3529,"Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.","Is the triple ""Ketorolac prevents Renal Colic"" supported by the sentence: ""Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.""?",False, +23612322,Ketorolac prevents Chronic pain,3530,"A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.","Is the triple ""Ketorolac prevents Chronic pain"" supported by the sentence: ""A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.""?",False, +20717559,Ketorolac prevents injury,3531,There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.,"Is the triple ""Ketorolac prevents injury"" supported by the sentence: ""There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.""?",False, +11362007,Ketorolac prevents Back pain,3532,Intradermal ketorolac for reduction of epidural back pain.,"Is the triple ""Ketorolac prevents Back pain"" supported by the sentence: ""Intradermal ketorolac for reduction of epidural back pain.""?",False, +11361661,Ketorolac prevents Inflammation,3533,CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.,"Is the triple ""Ketorolac prevents Inflammation"" supported by the sentence: ""CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.""?",False, +11043378,Ketorolac prevents Headache,3534,"At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).","Is the triple ""Ketorolac prevents Headache"" supported by the sentence: ""At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).""?",False, +7985904,Ketorolac prevents Pain,3535,Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.,"Is the triple ""Ketorolac prevents Pain"" supported by the sentence: ""Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.""?",False, +20028754,Ketorolac predisposes injury,3536,"The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.","Is the triple ""Ketorolac predisposes injury"" supported by the sentence: ""The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.""?",False, +25929768,Sulfadiazine related to congenital toxoplasmosis,3537,"[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].","Is the triple ""Sulfadiazine related to congenital toxoplasmosis"" supported by the sentence: ""[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].""?",False, +16546748,Sulfadiazine related to chorioretinitis,3538,"The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.","Is the triple ""Sulfadiazine related to chorioretinitis"" supported by the sentence: ""The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.""?",False, +27660461,Sulfamethoxazole causes pneumonia,3539,"Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.","Is the triple ""Sulfamethoxazole causes pneumonia"" supported by the sentence: ""Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.""?",False, +24328685,Sulfamethoxazole causes kidney disorder,3540,"In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.","Is the triple ""Sulfamethoxazole causes kidney disorder"" supported by the sentence: ""In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.""?",False, +14835537,Sulfamethoxazole affects cystic fibrosis,3541,The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).,"Is the triple ""Sulfamethoxazole affects cystic fibrosis"" supported by the sentence: ""The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).""?",False, +12226918,Sulfamethoxazole affects ocular toxoplasmosis,3542,PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.,"Is the triple ""Sulfamethoxazole affects ocular toxoplasmosis"" supported by the sentence: ""PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.""?",False, +26634163,Sulfamethoxazole prevents bacterial infectious disease,3543,These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.,"Is the triple ""Sulfamethoxazole prevents bacterial infectious disease"" supported by the sentence: ""These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.""?",False, +23781290,Sulfamethoxazole prevents Infection,3544,"Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.","Is the triple ""Sulfamethoxazole prevents Infection"" supported by the sentence: ""Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.""?",False, +22185408,Sulfamethoxazole prevents pneumocystosis,3545,The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.,"Is the triple ""Sulfamethoxazole prevents pneumocystosis"" supported by the sentence: ""The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.""?",False, +21716989,Glycyrrhizic acid affects osteoarthritis,3546,"However, it has not been reported whether glycyrrhizin has a positive effect on OA development.","Is the triple ""Glycyrrhizic acid affects osteoarthritis"" supported by the sentence: ""However, it has not been reported whether glycyrrhizin has a positive effect on OA development.""?",False, +21716987,Glycyrrhizic acid disrupts osteoarthritis,3547,Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.,"Is the triple ""Glycyrrhizic acid disrupts osteoarthritis"" supported by the sentence: ""Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.""?",False, +13246285,Ciclesonide related to perennial allergic rhinitis,3548,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to perennial allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, +13246284,Ciclesonide related to seasonal allergic rhinitis,3549,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to seasonal allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, +10789097,Ciclesonide related to asthma,3550,[Safety and efficacy of inhaled ciclesonide in asthma].,"Is the triple ""Ciclesonide related to asthma"" supported by the sentence: ""[Safety and efficacy of inhaled ciclesonide in asthma].""?",False, +13334776,Ciclesonide causes asthma,3551,Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.,"Is the triple ""Ciclesonide causes asthma"" supported by the sentence: ""Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.""?",False, +13603690,Ciclesonide affects asthma,3552,Ciclesonide improves measures of small airway involvement in asthma.,"Is the triple ""Ciclesonide affects asthma"" supported by the sentence: ""Ciclesonide improves measures of small airway involvement in asthma.""?",False, +26135729,Flunisolide related to perennial allergic rhinitis,3553,Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.,"Is the triple ""Flunisolide related to perennial allergic rhinitis"" supported by the sentence: ""Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.""?",False, +16438918,Flunisolide related to rhinitis,3554,"Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.","Is the triple ""Flunisolide related to rhinitis"" supported by the sentence: ""Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.""?",False, +7778368,Flunisolide related to asthma,3555,"Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.","Is the triple ""Flunisolide related to asthma"" supported by the sentence: ""Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.""?",False, +12189287,Flunisolide prevents Nasal congestion,3556,"The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.","Is the triple ""Flunisolide prevents Nasal congestion"" supported by the sentence: ""The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.""?",False, +27725383,Etoposide related to hepatoblastoma,3557,"Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.","Is the triple ""Etoposide related to hepatoblastoma"" supported by the sentence: ""Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.""?",False, +27360363,Etoposide related to ependymoma,3558,Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.,"Is the triple ""Etoposide related to ependymoma"" supported by the sentence: ""Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.""?",False, +27062931,Etoposide related to supratentorial primitive neuroectodermal tumor,3559,Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.,"Is the triple ""Etoposide related to supratentorial primitive neuroectodermal tumor"" supported by the sentence: ""Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.""?",False, +26965210,Etoposide related to kidney Wilms tumor,3560,"CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.","Is the triple ""Etoposide related to kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.""?",False, +26632944,Etoposide related to HIV infectious disease,3561,Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.,"Is the triple ""Etoposide related to HIV infectious disease"" supported by the sentence: ""Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.""?",False, +22727077,Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma,3562,"Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.","Is the triple ""Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.""?",False, +21142004,Etoposide related to AIDS,3563,"The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.","Is the triple ""Etoposide related to AIDS"" supported by the sentence: ""The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.""?",False, +20988037,Etoposide related to retinoblastoma,3564,"The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.","Is the triple ""Etoposide related to retinoblastoma"" supported by the sentence: ""The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.""?",False, +20394132,Etoposide related to B-cell neoplasm,3565,"Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.","Is the triple ""Etoposide related to B-cell neoplasm"" supported by the sentence: ""Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.""?",False, +19900770,Etoposide related to myelodysplastic syndrome,3566,Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.,"Is the triple ""Etoposide related to myelodysplastic syndrome"" supported by the sentence: ""Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.""?",False, +18768176,Etoposide related to hematopoietic and lymphoid system neoplasm,3567,"Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.","Is the triple ""Etoposide related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.""?",False, +17380085,Etoposide related to Kaposi's sarcoma,3568,"Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.","Is the triple ""Etoposide related to Kaposi's sarcoma"" supported by the sentence: ""Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.""?",False, +17284305,Etoposide related to bone osteosarcoma,3569,We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.,"Is the triple ""Etoposide related to bone osteosarcoma"" supported by the sentence: ""We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.""?",False, +17191209,Etoposide related to hepatocellular carcinoma,3570,The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).,"Is the triple ""Etoposide related to hepatocellular carcinoma"" supported by the sentence: ""The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).""?",False, +17136035,Etoposide related to diffuse large B-cell lymphoma,3571,"Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).","Is the triple ""Etoposide related to diffuse large B-cell lymphoma"" supported by the sentence: ""Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).""?",False, +16406847,Etoposide related to neuroendocrine carcinoma,3572,"However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.","Is the triple ""Etoposide related to neuroendocrine carcinoma"" supported by the sentence: ""However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.""?",False, +16067960,Etoposide related to cutaneous neuroendocrine carcinoma,3573,"In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.","Is the triple ""Etoposide related to cutaneous neuroendocrine carcinoma"" supported by the sentence: ""In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.""?",False, +15501025,Etoposide related to brain cancer,3574,"Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.","Is the triple ""Etoposide related to brain cancer"" supported by the sentence: ""Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.""?",False, +15141728,Etoposide related to testicular cancer,3575,[Continuous infusion of cisplatin plus etoposide in testicular cancer].,"Is the triple ""Etoposide related to testicular cancer"" supported by the sentence: ""[Continuous infusion of cisplatin plus etoposide in testicular cancer].""?",False, +15031494,Etoposide related to lymphoid leukemia,3576,"Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.","Is the triple ""Etoposide related to lymphoid leukemia"" supported by the sentence: ""Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.""?",False, +14511230,Etoposide related to glioblastoma,3577,Preliminary data by cis-platin and etoposide using in primary glioblastoma.,"Is the triple ""Etoposide related to glioblastoma"" supported by the sentence: ""Preliminary data by cis-platin and etoposide using in primary glioblastoma.""?",False, +14453465,Etoposide related to T-cell non-Hodgkin lymphoma,3578,High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).,"Is the triple ""Etoposide related to T-cell non-Hodgkin lymphoma"" supported by the sentence: ""High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).""?",False, +13764189,"Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive",3579,Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.,"Is the triple ""Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.""?",False, +12298091,Etoposide related to breast neoplasm,3580,"Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.","Is the triple ""Etoposide related to breast neoplasm"" supported by the sentence: ""Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.""?",False, +11028194,Etoposide related to acute lymphoblastic leukemia,3581,"Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.","Is the triple ""Etoposide related to acute lymphoblastic leukemia"" supported by the sentence: ""Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.""?",False, +10672040,Etoposide related to Ewing sarcoma,3582,Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.,"Is the triple ""Etoposide related to Ewing sarcoma"" supported by the sentence: ""Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.""?",False, +10503115,Etoposide related to kidney cancer,3583,We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.,"Is the triple ""Etoposide related to kidney cancer"" supported by the sentence: ""We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.""?",False, +10441577,Etoposide related to chronic myelomonocytic leukemia,3584,"Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.","Is the triple ""Etoposide related to chronic myelomonocytic leukemia"" supported by the sentence: ""Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.""?",False, +10410657,Etoposide related to neutropenia,3585,"The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).","Is the triple ""Etoposide related to neutropenia"" supported by the sentence: ""The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).""?",False, +10182075,Etoposide related to non-Hodgkin lymphoma,3586,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Etoposide related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, +10161953,Etoposide related to squamous cell carcinoma,3587,"Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.","Is the triple ""Etoposide related to squamous cell carcinoma"" supported by the sentence: ""Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.""?",False, +9231982,Etoposide related to carcinoma,3588,"In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].","Is the triple ""Etoposide related to carcinoma"" supported by the sentence: ""In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].""?",False, +9157972,Etoposide related to thymoma,3589,"High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.","Is the triple ""Etoposide related to thymoma"" supported by the sentence: ""High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.""?",False, +9138703,Etoposide related to ovarian cancer,3590,A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.,"Is the triple ""Etoposide related to ovarian cancer"" supported by the sentence: ""A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.""?",False, +9115115,Etoposide related to sarcoma,3591,"The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.","Is the triple ""Etoposide related to sarcoma"" supported by the sentence: ""The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.""?",False, +9024985,Etoposide related to leukemia,3592,The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.,"Is the triple ""Etoposide related to leukemia"" supported by the sentence: ""The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.""?",False, +9008448,Etoposide related to Hodgkins lymphoma,3593,"Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.","Is the triple ""Etoposide related to Hodgkins lymphoma"" supported by the sentence: ""Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.""?",False, +9006645,Etoposide related to neuroblastoma,3594,Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.,"Is the triple ""Etoposide related to neuroblastoma"" supported by the sentence: ""Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.""?",False, +8074798,Etoposide related to medulloblastoma,3595,"When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.","Is the triple ""Etoposide related to medulloblastoma"" supported by the sentence: ""When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.""?",False, +8048523,Etoposide related to lymphoma,3596,Oral etoposide in lymphoma.,"Is the triple ""Etoposide related to lymphoma"" supported by the sentence: ""Oral etoposide in lymphoma.""?",False, +7998504,Etoposide related to plasma cell myeloma,3597,"Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.","Is the triple ""Etoposide related to plasma cell myeloma"" supported by the sentence: ""Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.""?",False, +7989979,Etoposide related to neoplasm,3598,"Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.","Is the triple ""Etoposide related to neoplasm"" supported by the sentence: ""Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.""?",False, +7896801,Etoposide related to adult T-cell leukemia/lymphoma,3599,"Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.","Is the triple ""Etoposide related to adult T-cell leukemia/lymphoma"" supported by the sentence: ""Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.""?",False, +7845509,Etoposide related to glioma,3600,Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.,"Is the triple ""Etoposide related to glioma"" supported by the sentence: ""Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.""?",False, +7810052,Etoposide related to castration-resistant prostate carcinoma,3601,"Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.","Is the triple ""Etoposide related to castration-resistant prostate carcinoma"" supported by the sentence: ""Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.""?",False, +7711547,Etoposide related to acute myeloid leukemia,3602,Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.,"Is the triple ""Etoposide related to acute myeloid leukemia"" supported by the sentence: ""Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.""?",False, +7319060,Etoposide related to small cell lung carcinoma,3603,Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.,"Is the triple ""Etoposide related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.""?",False, +7200681,Etoposide related to non-small cell lung carcinoma,3604,Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.,"Is the triple ""Etoposide related to non-small cell lung carcinoma"" supported by the sentence: ""Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.""?",False, +23328204,Etoposide causes small cell lung carcinoma,3605,This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.,"Is the triple ""Etoposide causes small cell lung carcinoma"" supported by the sentence: ""This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.""?",False, +12215704,Etoposide causes neoplasm,3606,"In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.","Is the triple ""Etoposide causes neoplasm"" supported by the sentence: ""In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.""?",False, +8706370,Etoposide causes neutropenia,3607,"The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.","Is the triple ""Etoposide causes neutropenia"" supported by the sentence: ""The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.""?",False, +7869845,Etoposide causes leukemia,3608,"There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.","Is the triple ""Etoposide causes leukemia"" supported by the sentence: ""There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.""?",False, +7642766,Etoposide causes acute myeloid leukemia,3609,Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.,"Is the triple ""Etoposide causes acute myeloid leukemia"" supported by the sentence: ""Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.""?",False, +27374335,Etoposide affects retinoblastoma,3610,"METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.","Is the triple ""Etoposide affects retinoblastoma"" supported by the sentence: ""METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.""?",False, +26960810,Etoposide affects small cell lung carcinoma,3611,"BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.","Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.""?",False, +25269562,Etoposide affects hemophagocytic syndrome,3612,"She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.","Is the triple ""Etoposide affects hemophagocytic syndrome"" supported by the sentence: ""She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.""?",False, +23238600,Etoposide affects choriocarcinoma,3613,[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].,"Is the triple ""Etoposide affects choriocarcinoma"" supported by the sentence: ""[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].""?",False, +18166706,Etoposide affects neuroblastoma,3614,Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.,"Is the triple ""Etoposide affects neuroblastoma"" supported by the sentence: ""Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.""?",False, +17967080,Etoposide affects leukemia,3615,"Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.""?",False, +17160632,Etoposide affects carcinoma,3616,The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.,"Is the triple ""Etoposide affects carcinoma"" supported by the sentence: ""The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.""?",False, +16724406,Etoposide affects neoplasm,3617,The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.,"Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.""?",False, +16425822,Etoposide affects leukemia,3618,"Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.""?",False, +15965763,Etoposide affects testicular cancer,3619,"Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).","Is the triple ""Etoposide affects testicular cancer"" supported by the sentence: ""Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).""?",False, +12798395,Etoposide affects hematopoietic and lymphoid system neoplasm,3620,Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.,"Is the triple ""Etoposide affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.""?",False, +11699750,Etoposide affects small cell lung carcinoma,3621,CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.,"Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.""?",False, +11396769,Etoposide affects chronic myelomonocytic leukemia,3622,"He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.","Is the triple ""Etoposide affects chronic myelomonocytic leukemia"" supported by the sentence: ""He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.""?",False, +9913818,Etoposide affects acute erythroid leukemia,3623,"Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.","Is the triple ""Etoposide affects acute erythroid leukemia"" supported by the sentence: ""Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.""?",False, +9397866,Etoposide affects fallopian tube neoplasm,3624,Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.,"Is the triple ""Etoposide affects fallopian tube neoplasm"" supported by the sentence: ""Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.""?",False, +9293530,Etoposide affects carcinoid tumor,3625,Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.,"Is the triple ""Etoposide affects carcinoid tumor"" supported by the sentence: ""Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.""?",False, +8200378,Etoposide affects neoplasm,3626,"Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.","Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.""?",False, +8003315,Etoposide affects cutaneous neuroendocrine carcinoma,3627,"We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.","Is the triple ""Etoposide affects cutaneous neuroendocrine carcinoma"" supported by the sentence: ""We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.""?",False, +7908520,Etoposide affects B-cell neoplasm,3628,CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).,"Is the triple ""Etoposide affects B-cell neoplasm"" supported by the sentence: ""CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).""?",False, +24115005,Etoposide disrupts small cell lung carcinoma,3629,In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.,"Is the triple ""Etoposide disrupts small cell lung carcinoma"" supported by the sentence: ""In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.""?",False, +17149618,Etoposide disrupts hemophagocytic syndrome,3630,Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).,"Is the triple ""Etoposide disrupts hemophagocytic syndrome"" supported by the sentence: ""Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).""?",False, +16511954,Etoposide disrupts glioblastoma,3631,"In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.","Is the triple ""Etoposide disrupts glioblastoma"" supported by the sentence: ""In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.""?",False, +16039903,Etoposide disrupts neoplasm,3632,"While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).","Is the triple ""Etoposide disrupts neoplasm"" supported by the sentence: ""While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).""?",False, +14383828,Etoposide disrupts bone osteosarcoma,3633,CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).,"Is the triple ""Etoposide disrupts bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).""?",False, +9134229,Etoposide prevents neoplasm,3634,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Etoposide prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, +22634859,Etoposide predisposes neoplasm,3635,Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.,"Is the triple ""Etoposide predisposes neoplasm"" supported by the sentence: ""Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.""?",False, +18673787,Etoposide predisposes brain cancer,3636,"Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.","Is the triple ""Etoposide predisposes brain cancer"" supported by the sentence: ""Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.""?",False, +16345738,Etoposide predisposes myelodysplastic syndrome,3637,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes myelodysplastic syndrome"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, +16345737,Etoposide predisposes acute myeloid leukemia,3638,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes acute myeloid leukemia"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, +10333072,Etoposide predisposes leukemia,3639,"Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.","Is the triple ""Etoposide predisposes leukemia"" supported by the sentence: ""Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.""?",False, +16677028,Teniposide related to neoplasm,3640,"Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.","Is the triple ""Teniposide related to neoplasm"" supported by the sentence: ""Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.""?",False, +10688707,Teniposide related to lymphoma,3641,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to lymphoma"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, +10688706,Teniposide related to leukemia,3642,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to leukemia"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, +27095076,Teniposide affects leukemia,3643,"These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.","Is the triple ""Teniposide affects leukemia"" supported by the sentence: ""These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.""?",False, +26849066,Teniposide predisposes leukemia,3644,"CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.","Is the triple ""Teniposide predisposes leukemia"" supported by the sentence: ""CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.""?",False, +18768362,Urofollitropin related to hypogonadism,3645,"RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.","Is the triple ""Urofollitropin related to hypogonadism"" supported by the sentence: ""RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.""?",False, +18095820,Urofollitropin related to primary ovarian failure,3646,"In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.","Is the triple ""Urofollitropin related to primary ovarian failure"" supported by the sentence: ""In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.""?",False, +9960851,Urofollitropin related to anovulation,3647,Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.,"Is the triple ""Urofollitropin related to anovulation"" supported by the sentence: ""Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.""?",False, +9716197,Urofollitropin related to female infertility,3648,OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.,"Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.""?",False, +8496709,Urofollitropin related to infertility disorder,3649,"BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.","Is the triple ""Urofollitropin related to infertility disorder"" supported by the sentence: ""BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.""?",False, +8454088,Urofollitropin related to male infertility,3650,Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.,"Is the triple ""Urofollitropin related to male infertility"" supported by the sentence: ""Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.""?",False, +8378642,Urofollitropin related to polycystic ovary syndrome,3651,"From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.","Is the triple ""Urofollitropin related to polycystic ovary syndrome"" supported by the sentence: ""From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.""?",False, +8205307,Urofollitropin related to azoospermia,3652,"Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.","Is the triple ""Urofollitropin related to azoospermia"" supported by the sentence: ""Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.""?",False, +14878529,Urofollitropin related to female infertility,3653,"OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).","Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).""?",False, +9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3654,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, +9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3655,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, +10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3656,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, +10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3657,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, +7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3658,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, +7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3659,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, +7302412,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3660,The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.,"Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.""?",False, +7606444,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3661,"The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.","Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.""?",False, +21372974,Urofollitropin causes polycystic ovary syndrome,3662,"In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.","Is the triple ""Urofollitropin causes polycystic ovary syndrome"" supported by the sentence: ""In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.""?",False, +16723493,Urofollitropin causes hypogonadism,3663,"FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.","Is the triple ""Urofollitropin causes hypogonadism"" supported by the sentence: ""FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.""?",False, +16322495,Urofollitropin causes azoospermia,3664,Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.,"Is the triple ""Urofollitropin causes azoospermia"" supported by the sentence: ""Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.""?",False, +9453052,Urofollitropin causes primary ovarian failure,3665,"An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.","Is the triple ""Urofollitropin causes primary ovarian failure"" supported by the sentence: ""An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.""?",False, +8923757,Urofollitropin causes Pregnancy,3666,"However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.","Is the triple ""Urofollitropin causes Pregnancy"" supported by the sentence: ""However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.""?",False, +8815215,Urofollitropin causes anovulation,3667,"Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.","Is the triple ""Urofollitropin causes anovulation"" supported by the sentence: ""Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.""?",False, +8590972,Urofollitropin causes male infertility,3668,"Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.","Is the triple ""Urofollitropin causes male infertility"" supported by the sentence: ""Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.""?",False, +8270576,Urofollitropin causes infertility disorder,3669,Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.,"Is the triple ""Urofollitropin causes infertility disorder"" supported by the sentence: ""Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.""?",False, +19357829,Urofollitropin affects gonadal disorder,3670,"Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.","Is the triple ""Urofollitropin affects gonadal disorder"" supported by the sentence: ""Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.""?",False, +15865492,Urofollitropin affects polycystic ovary syndrome,3671,"The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.","Is the triple ""Urofollitropin affects polycystic ovary syndrome"" supported by the sentence: ""The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.""?",False, +14984090,Urofollitropin affects male infertility,3672,The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.""?",False, +13249247,Urofollitropin affects Pregnancy,3673,"CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.","Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.""?",False, +10980447,Urofollitropin affects Pregnancy,3674,BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.,"Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.""?",False, +8590971,Urofollitropin affects male infertility,3675,The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.""?",False, +7302415,Urofollitropin affects Follicle Stimulating Hormone Receptor,3676,These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.""?",False, +9844029,Urofollitropin affects Follicle Stimulating Hormone Receptor,3677,This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.""?",False, +27587327,Urofollitropin produces primary ovarian failure,3678,"Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).","Is the triple ""Urofollitropin produces primary ovarian failure"" supported by the sentence: ""Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).""?",False, +20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3679,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, +20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3680,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, +8502213,Urofollitropin produces polycystic ovary syndrome,3681,"RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.","Is the triple ""Urofollitropin produces polycystic ovary syndrome"" supported by the sentence: ""RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.""?",False, +20569186,Urofollitropin disrupts Pregnancy,3682,"RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.","Is the triple ""Urofollitropin disrupts Pregnancy"" supported by the sentence: ""RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.""?",False, +11195885,Urofollitropin prevents azoospermia,3683,"While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.","Is the triple ""Urofollitropin prevents azoospermia"" supported by the sentence: ""While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.""?",False, +17502146,Urofollitropin predisposes azoospermia,3684,"On multivariate analysis, only FSH remained predictive of NOA.","Is the triple ""Urofollitropin predisposes azoospermia"" supported by the sentence: ""On multivariate analysis, only FSH remained predictive of NOA.""?",False, +16417247,Urofollitropin predisposes anovulation,3685,"CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.","Is the triple ""Urofollitropin predisposes anovulation"" supported by the sentence: ""CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.""?",False, +16278695,Urofollitropin predisposes infertility disorder,3686,"The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).","Is the triple ""Urofollitropin predisposes infertility disorder"" supported by the sentence: ""The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).""?",False, +15110465,Urofollitropin predisposes polycystic ovary syndrome,3687,"LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).","Is the triple ""Urofollitropin predisposes polycystic ovary syndrome"" supported by the sentence: ""LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).""?",False, +7379891,Urofollitropin predisposes primary ovarian failure,3688,Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.,"Is the triple ""Urofollitropin predisposes primary ovarian failure"" supported by the sentence: ""Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.""?",False, +23895216,Ivacaftor affects cystic fibrosis,3689,Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.,"Is the triple ""Ivacaftor affects cystic fibrosis"" supported by the sentence: ""Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.""?",False, +20354463,Nitric oxide related to ST-elevation myocardial infarction,3690,The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.,"Is the triple ""Nitric oxide related to ST-elevation myocardial infarction"" supported by the sentence: ""The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.""?",False, +17273075,Nitric oxide related to bronchiolitis,3691,"By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.","Is the triple ""Nitric oxide related to bronchiolitis"" supported by the sentence: ""By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.""?",False, +15880296,Nitric oxide related to Diabetic Foot,3692,"Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).","Is the triple ""Nitric oxide related to Diabetic Foot"" supported by the sentence: ""Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).""?",False, +14910010,Nitric oxide related to severe acute respiratory syndrome,3693,Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.,"Is the triple ""Nitric oxide related to severe acute respiratory syndrome"" supported by the sentence: ""Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.""?",False, +14573099,Nitric oxide related to bronchopulmonary dysplasia,3694,"The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.","Is the triple ""Nitric oxide related to bronchopulmonary dysplasia"" supported by the sentence: ""The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.""?",False, +11752178,Nitric oxide related to cutaneous leishmaniasis,3695,"Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.","Is the triple ""Nitric oxide related to cutaneous leishmaniasis"" supported by the sentence: ""Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.""?",False, +9816415,Nitric oxide related to newborn respiratory distress syndrome,3696,"To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.","Is the triple ""Nitric oxide related to newborn respiratory distress syndrome"" supported by the sentence: ""To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.""?",False, +9774015,Nitric oxide related to respiratory system disorder,3697,Nitric oxide in respiratory diseases.,"Is the triple ""Nitric oxide related to respiratory system disorder"" supported by the sentence: ""Nitric oxide in respiratory diseases.""?",False, +8707490,Nitric oxide related to myocardial infarction,3698,"Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.","Is the triple ""Nitric oxide related to myocardial infarction"" supported by the sentence: ""Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.""?",False, +8593326,Nitric oxide related to neuralgia,3699,This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.,"Is the triple ""Nitric oxide related to neuralgia"" supported by the sentence: ""This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.""?",False, +8476870,Nitric oxide related to lung disorder,3700,"Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.","Is the triple ""Nitric oxide related to lung disorder"" supported by the sentence: ""Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.""?",False, +8350800,Nitric oxide related to opiate dependence,3701,"RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.","Is the triple ""Nitric oxide related to opiate dependence"" supported by the sentence: ""RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.""?",False, +8343542,Nitric oxide related to Varicose Ulcer,3702,"NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.","Is the triple ""Nitric oxide related to Varicose Ulcer"" supported by the sentence: ""NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.""?",False, +8057943,Nitric oxide related to malaria,3703,Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.,"Is the triple ""Nitric oxide related to malaria"" supported by the sentence: ""Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.""?",False, +8040944,Nitric oxide related to sickle cell anemia,3704,Strategies that enhance NO activity may be therapeutic in sickle cell disease.,"Is the triple ""Nitric oxide related to sickle cell anemia"" supported by the sentence: ""Strategies that enhance NO activity may be therapeutic in sickle cell disease.""?",False, +7963930,Nitric oxide related to cystic fibrosis,3705,"As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.","Is the triple ""Nitric oxide related to cystic fibrosis"" supported by the sentence: ""As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.""?",False, +7923041,Nitric oxide related to brain injury,3706,"While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.","Is the triple ""Nitric oxide related to brain injury"" supported by the sentence: ""While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.""?",False, +7788094,Nitric oxide related to myocardial ischemia,3707,"This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.","Is the triple ""Nitric oxide related to myocardial ischemia"" supported by the sentence: ""This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.""?",False, +7738003,Nitric oxide related to Hypoxemia,3708,"In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.","Is the triple ""Nitric oxide related to Hypoxemia"" supported by the sentence: ""In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.""?",False, +7725812,Nitric oxide related to Premature birth,3709,"Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.","Is the triple ""Nitric oxide related to Premature birth"" supported by the sentence: ""Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.""?",False, +7657450,Nitric oxide related to pulmonary embolism,3710,Use of inhaled nitric oxide in pulmonary embolism.,"Is the triple ""Nitric oxide related to pulmonary embolism"" supported by the sentence: ""Use of inhaled nitric oxide in pulmonary embolism.""?",False, +7539810,Nitric oxide related to stroke disorder,3711,The findings indicate the importance of nitric oxide in stroke and ischemia.,"Is the triple ""Nitric oxide related to stroke disorder"" supported by the sentence: ""The findings indicate the importance of nitric oxide in stroke and ischemia.""?",False, +7481315,Nitric oxide related to chronic obstructive pulmonary disease,3712,Exhaled nitric oxide in COPD: glancing through a smoke screen.,"Is the triple ""Nitric oxide related to chronic obstructive pulmonary disease"" supported by the sentence: ""Exhaled nitric oxide in COPD: glancing through a smoke screen.""?",False, +7449413,Nitric oxide related to respiratory failure,3713,Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.,"Is the triple ""Nitric oxide related to respiratory failure"" supported by the sentence: ""Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.""?",False, +7439172,Nitric oxide related to neoplasm,3714,"Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.","Is the triple ""Nitric oxide related to neoplasm"" supported by the sentence: ""Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.""?",False, +7418030,Nitric oxide related to acute kidney failure,3715,BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.,"Is the triple ""Nitric oxide related to acute kidney failure"" supported by the sentence: ""BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.""?",False, +7373096,Nitric oxide related to brain ischemia,3716,"Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.","Is the triple ""Nitric oxide related to brain ischemia"" supported by the sentence: ""Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.""?",False, +7345317,Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins,3717,"CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.","Is the triple ""Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.""?",False, +7242606,Nitric oxide related to adult acute respiratory distress syndrome,3718,Inhaled nitric oxide may also have therapeutic potential in ARDS.,"Is the triple ""Nitric oxide related to adult acute respiratory distress syndrome"" supported by the sentence: ""Inhaled nitric oxide may also have therapeutic potential in ARDS.""?",False, +7159413,Nitric oxide related to Sepsis,3719,"CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.","Is the triple ""Nitric oxide related to Sepsis"" supported by the sentence: ""CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.""?",False, +7145311,Nitric oxide related to Inflammation,3720,Nitric oxide protects in intestinal inflammation.,"Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Nitric oxide protects in intestinal inflammation.""?",False, +7091337,Nitric oxide related to ischemia reperfusion injury,3721,This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.,"Is the triple ""Nitric oxide related to ischemia reperfusion injury"" supported by the sentence: ""This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.""?",False, +14184908,Nitric oxide related to Inflammation,3722,"Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.","Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.""?",False, +27698007,Nitric oxide causes lung disorder,3723,"Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.","Is the triple ""Nitric oxide causes lung disorder"" supported by the sentence: ""Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.""?",False, +23636922,Nitric oxide causes Infection,3724,"Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.","Is the triple ""Nitric oxide causes Infection"" supported by the sentence: ""Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.""?",False, +22013082,Nitric oxide causes sickle cell anemia,3725,"Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.","Is the triple ""Nitric oxide causes sickle cell anemia"" supported by the sentence: ""Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.""?",False, +21447838,Nitric oxide causes respiratory system disorder,3726,NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.,"Is the triple ""Nitric oxide causes respiratory system disorder"" supported by the sentence: ""NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.""?",False, +14028136,Nitric oxide causes stroke disorder,3727,"OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.","Is the triple ""Nitric oxide causes stroke disorder"" supported by the sentence: ""OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.""?",False, +12046903,Nitric oxide causes cystic fibrosis,3728,CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.,"Is the triple ""Nitric oxide causes cystic fibrosis"" supported by the sentence: ""CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.""?",False, +11887505,Nitric oxide causes myocardial ischemia,3729,"RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.","Is the triple ""Nitric oxide causes myocardial ischemia"" supported by the sentence: ""RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.""?",False, +11842330,Nitric oxide causes ischemia reperfusion injury,3730,BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).,"Is the triple ""Nitric oxide causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).""?",False, +11556568,Nitric oxide causes acute kidney failure,3731,NO plays a dual role of protection and damage in the pathogenesis of ARF.,"Is the triple ""Nitric oxide causes acute kidney failure"" supported by the sentence: ""NO plays a dual role of protection and damage in the pathogenesis of ARF.""?",False, +11353052,Nitric oxide causes adult acute respiratory distress syndrome,3732,"CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.","Is the triple ""Nitric oxide causes adult acute respiratory distress syndrome"" supported by the sentence: ""CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.""?",False, +9962165,Nitric oxide causes malaria,3733,We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.,"Is the triple ""Nitric oxide causes malaria"" supported by the sentence: ""We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.""?",False, +9795722,Nitric oxide causes neuralgia,3734,OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.,"Is the triple ""Nitric oxide causes neuralgia"" supported by the sentence: ""OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.""?",False, +9068211,Nitric oxide causes pneumonia,3735,"A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.","Is the triple ""Nitric oxide causes pneumonia"" supported by the sentence: ""A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.""?",False, +8934561,Nitric oxide causes brain injury,3736,"It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.","Is the triple ""Nitric oxide causes brain injury"" supported by the sentence: ""It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.""?",False, +8855613,Nitric oxide causes neoplasm,3737,Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.,"Is the triple ""Nitric oxide causes neoplasm"" supported by the sentence: ""Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.""?",False, +8834736,Nitric oxide causes myocardial infarction,3738,"Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.","Is the triple ""Nitric oxide causes myocardial infarction"" supported by the sentence: ""Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.""?",False, +8346309,Nitric oxide causes Premature birth,3739,The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.,"Is the triple ""Nitric oxide causes Premature birth"" supported by the sentence: ""The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.""?",False, +8185371,Nitric oxide causes Inflammation,3740,Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.,"Is the triple ""Nitric oxide causes Inflammation"" supported by the sentence: ""Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.""?",False, +8037779,Nitric oxide causes brain ischemia,3741,"Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.","Is the triple ""Nitric oxide causes brain ischemia"" supported by the sentence: ""Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.""?",False, +7409857,Nitric oxide causes Sepsis,3742,Nitric oxide in the pathogenesis of sepsis.,"Is the triple ""Nitric oxide causes Sepsis"" supported by the sentence: ""Nitric oxide in the pathogenesis of sepsis.""?",False, +7184490,Nitric oxide causes Hypoxemia,3743,These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.,"Is the triple ""Nitric oxide causes Hypoxemia"" supported by the sentence: ""These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.""?",False, +27626134,Nitric oxide affects cystic fibrosis,3744,"We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.","Is the triple ""Nitric oxide affects cystic fibrosis"" supported by the sentence: ""We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.""?",False, +27208311,Nitric oxide affects opiate dependence,3745,"NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.","Is the triple ""Nitric oxide affects opiate dependence"" supported by the sentence: ""NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.""?",False, +27058878,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3746,The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.,"Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.""?",False, +20413999,Nitric oxide affects brain injury,3747,"Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.","Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.""?",False, +19764415,Nitric oxide affects pneumonia,3748,"Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.""?",False, +18632674,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3749,"We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.","Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.""?",False, +17798838,Nitric oxide affects neuralgia,3750,"All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.","Is the triple ""Nitric oxide affects neuralgia"" supported by the sentence: ""All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.""?",False, +17030125,Nitric oxide affects bronchiolitis,3751,Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.,"Is the triple ""Nitric oxide affects bronchiolitis"" supported by the sentence: ""Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.""?",False, +12566083,Nitric oxide affects respiratory system disorder,3752,Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.,"Is the triple ""Nitric oxide affects respiratory system disorder"" supported by the sentence: ""Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.""?",False, +11778681,Nitric oxide affects stroke disorder,3753,Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.,"Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.""?",False, +11521495,Nitric oxide affects severe acute respiratory syndrome,3754,"These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.","Is the triple ""Nitric oxide affects severe acute respiratory syndrome"" supported by the sentence: ""These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.""?",False, +11353389,Nitric oxide affects myocardial infarction,3755,Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.,"Is the triple ""Nitric oxide affects myocardial infarction"" supported by the sentence: ""Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.""?",False, +10403969,Nitric oxide affects anemia,3756,"Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.""?",False, +10222313,Nitric oxide affects ischemia reperfusion injury,3757,CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.,"Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.""?",False, +10099288,Nitric oxide affects myocardial ischemia,3758,Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.""?",False, +10018002,Nitric oxide affects acute kidney failure,3759,"Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.","Is the triple ""Nitric oxide affects acute kidney failure"" supported by the sentence: ""Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.""?",False, +10008267,Nitric oxide affects lung disorder,3760,"Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.","Is the triple ""Nitric oxide affects lung disorder"" supported by the sentence: ""Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.""?",False, +9982988,Nitric oxide affects respiratory failure,3761,Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.,"Is the triple ""Nitric oxide affects respiratory failure"" supported by the sentence: ""Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.""?",False, +9910920,Nitric oxide affects brain ischemia,3762,These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.,"Is the triple ""Nitric oxide affects brain ischemia"" supported by the sentence: ""These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.""?",False, +9742582,Nitric oxide affects stroke disorder,3763,"The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.","Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.""?",False, +9649727,Nitric oxide affects neoplasm,3764,Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.""?",False, +9102608,Nitric oxide affects Hypoxemia,3765,Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.,"Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.""?",False, +9095187,Nitric oxide affects newborn respiratory distress syndrome,3766,"There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.","Is the triple ""Nitric oxide affects newborn respiratory distress syndrome"" supported by the sentence: ""There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.""?",False, +8891949,Nitric oxide affects Sepsis,3767,"Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.""?",False, +8832872,Nitric oxide affects pneumonia,3768,"The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.""?",False, +8646255,Nitric oxide affects myocardial ischemia,3769,The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.""?",False, +8473168,Nitric oxide affects neoplasm,3770,NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.""?",False, +8202584,Nitric oxide affects Sepsis,3771,"Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.""?",False, +8139693,Nitric oxide affects brain injury,3772,Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.,"Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.""?",False, +7935763,Nitric oxide affects chronic obstructive pulmonary disease,3773,The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.""?",False, +7896362,Nitric oxide affects Inflammation,3774,"Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.","Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.""?",False, +7780898,Nitric oxide affects chronic obstructive pulmonary disease,3775,Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.""?",False, +7712088,Nitric oxide affects Hypoxemia,3776,"By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.","Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.""?",False, +7542916,Nitric oxide affects anemia,3777,"Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).""?",False, +7169788,Nitric oxide affects Inflammation,3778,Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.,"Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.""?",False, +7164340,Nitric oxide affects ischemia reperfusion injury,3779,"The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.","Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.""?",False, +7094195,Nitric oxide affects malaria,3780,Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.,"Is the triple ""Nitric oxide affects malaria"" supported by the sentence: ""Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.""?",False, +20359925,Nitric oxide produces chronic obstructive pulmonary disease,3781,"However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.","Is the triple ""Nitric oxide produces chronic obstructive pulmonary disease"" supported by the sentence: ""However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.""?",False, +20299429,Nitric oxide produces pneumonia,3782,We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.,"Is the triple ""Nitric oxide produces pneumonia"" supported by the sentence: ""We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.""?",False, +17925357,Nitric oxide produces bronchopulmonary dysplasia,3783,"The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.","Is the triple ""Nitric oxide produces bronchopulmonary dysplasia"" supported by the sentence: ""The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.""?",False, +15219259,Nitric oxide produces Premature birth,3784,CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.,"Is the triple ""Nitric oxide produces Premature birth"" supported by the sentence: ""CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.""?",False, +13106727,Nitric oxide produces adult acute respiratory distress syndrome,3785,"Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.","Is the triple ""Nitric oxide produces adult acute respiratory distress syndrome"" supported by the sentence: ""Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.""?",False, +12774415,Nitric oxide produces stroke disorder,3786,The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.,"Is the triple ""Nitric oxide produces stroke disorder"" supported by the sentence: ""The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.""?",False, +12205025,Nitric oxide produces Varicose Ulcer,3787,"The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.","Is the triple ""Nitric oxide produces Varicose Ulcer"" supported by the sentence: ""The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.""?",False, +11786457,Nitric oxide produces brain ischemia,3788,"One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.","Is the triple ""Nitric oxide produces brain ischemia"" supported by the sentence: ""One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.""?",False, +9816411,Nitric oxide produces newborn respiratory distress syndrome,3789,Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.,"Is the triple ""Nitric oxide produces newborn respiratory distress syndrome"" supported by the sentence: ""Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.""?",False, +8745644,Nitric oxide produces sickle cell anemia,3790,We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.,"Is the triple ""Nitric oxide produces sickle cell anemia"" supported by the sentence: ""We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.""?",False, +8339020,Nitric oxide produces acute kidney failure,3791,"In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.","Is the triple ""Nitric oxide produces acute kidney failure"" supported by the sentence: ""In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.""?",False, +7963932,Nitric oxide produces cystic fibrosis,3792,The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.,"Is the triple ""Nitric oxide produces cystic fibrosis"" supported by the sentence: ""The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.""?",False, +7644756,Nitric oxide produces anemia,3793,"Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.","Is the triple ""Nitric oxide produces anemia"" supported by the sentence: ""Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.""?",False, +7555266,Nitric oxide produces myocardial ischemia,3794,Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.,"Is the triple ""Nitric oxide produces myocardial ischemia"" supported by the sentence: ""Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.""?",False, +7511323,Nitric oxide produces myocardial infarction,3795,"The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).","Is the triple ""Nitric oxide produces myocardial infarction"" supported by the sentence: ""The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).""?",False, +7507297,Nitric oxide produces Inflammation,3796,Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.,"Is the triple ""Nitric oxide produces Inflammation"" supported by the sentence: ""Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.""?",False, +7461061,Nitric oxide produces Hypoxemia,3797,"Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.","Is the triple ""Nitric oxide produces Hypoxemia"" supported by the sentence: ""Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.""?",False, +7435212,Nitric oxide produces neoplasm,3798,"Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.","Is the triple ""Nitric oxide produces neoplasm"" supported by the sentence: ""Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.""?",False, +7390889,Nitric oxide produces Sepsis,3799,"In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.","Is the triple ""Nitric oxide produces Sepsis"" supported by the sentence: ""In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.""?",False, +7094197,Nitric oxide produces malaria,3800,"However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.","Is the triple ""Nitric oxide produces malaria"" supported by the sentence: ""However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.""?",False, +26705109,Nitric oxide disrupts anemia,3801,"NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.","Is the triple ""Nitric oxide disrupts anemia"" supported by the sentence: ""NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.""?",False, +19923810,Nitric oxide disrupts stroke disorder,3802,"CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.","Is the triple ""Nitric oxide disrupts stroke disorder"" supported by the sentence: ""CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.""?",False, +14786185,Nitric oxide disrupts Sepsis,3803,Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.,"Is the triple ""Nitric oxide disrupts Sepsis"" supported by the sentence: ""Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.""?",False, +12247489,Nitric oxide disrupts sickle cell anemia,3804,"Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.","Is the triple ""Nitric oxide disrupts sickle cell anemia"" supported by the sentence: ""Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.""?",False, +11088644,Nitric oxide disrupts cystic fibrosis,3805,"Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.","Is the triple ""Nitric oxide disrupts cystic fibrosis"" supported by the sentence: ""Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.""?",False, +10963665,Nitric oxide disrupts neoplasm,3806,"Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.","Is the triple ""Nitric oxide disrupts neoplasm"" supported by the sentence: ""Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.""?",False, +10158293,Nitric oxide disrupts myocardial ischemia,3807,"Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.","Is the triple ""Nitric oxide disrupts myocardial ischemia"" supported by the sentence: ""Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.""?",False, +9091818,Nitric oxide disrupts respiratory failure,3808,"However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.","Is the triple ""Nitric oxide disrupts respiratory failure"" supported by the sentence: ""However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.""?",False, +8577648,Nitric oxide disrupts Inflammation,3809,In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.,"Is the triple ""Nitric oxide disrupts Inflammation"" supported by the sentence: ""In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.""?",False, +7822328,Nitric oxide disrupts adult acute respiratory distress syndrome,3810,BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).,"Is the triple ""Nitric oxide disrupts adult acute respiratory distress syndrome"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).""?",False, +7750750,Nitric oxide disrupts myocardial infarction,3811,"Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.","Is the triple ""Nitric oxide disrupts myocardial infarction"" supported by the sentence: ""Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.""?",False, +7555296,Nitric oxide disrupts ischemia reperfusion injury,3812,NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.,"Is the triple ""Nitric oxide disrupts ischemia reperfusion injury"" supported by the sentence: ""NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.""?",False, +7358959,Nitric oxide disrupts Hypoxemia,3813,CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.,"Is the triple ""Nitric oxide disrupts Hypoxemia"" supported by the sentence: ""CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.""?",False, +26913950,Nitric oxide prevents adult acute respiratory distress syndrome,3814,"Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.","Is the triple ""Nitric oxide prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.""?",False, +25277893,Nitric oxide prevents neuralgia,3815,"Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.","Is the triple ""Nitric oxide prevents neuralgia"" supported by the sentence: ""Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.""?",False, +22898445,Nitric oxide prevents Infection,3816,The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.,"Is the triple ""Nitric oxide prevents Infection"" supported by the sentence: ""The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.""?",False, +21669107,Nitric oxide prevents neoplasm,3817,"CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.","Is the triple ""Nitric oxide prevents neoplasm"" supported by the sentence: ""CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.""?",False, +21628822,Nitric oxide prevents Hypoxemia,3818,"The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.","Is the triple ""Nitric oxide prevents Hypoxemia"" supported by the sentence: ""The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.""?",False, +21494876,Nitric oxide prevents Inflammation,3819,"This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.","Is the triple ""Nitric oxide prevents Inflammation"" supported by the sentence: ""This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.""?",False, +21062009,Nitric oxide prevents pulmonary embolism,3820,"Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.","Is the triple ""Nitric oxide prevents pulmonary embolism"" supported by the sentence: ""Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.""?",False, +16675253,Nitric oxide prevents stroke disorder,3821,"Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.","Is the triple ""Nitric oxide prevents stroke disorder"" supported by the sentence: ""Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.""?",False, +13634130,Nitric oxide prevents sickle cell anemia,3822,"Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).","Is the triple ""Nitric oxide prevents sickle cell anemia"" supported by the sentence: ""Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).""?",False, +11584828,Nitric oxide prevents brain ischemia,3823,"CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.","Is the triple ""Nitric oxide prevents brain ischemia"" supported by the sentence: ""CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.""?",False, +11450951,Nitric oxide prevents myocardial infarction,3824,BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.,"Is the triple ""Nitric oxide prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.""?",False, +10887585,Nitric oxide prevents pneumonia,3825,"BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.","Is the triple ""Nitric oxide prevents pneumonia"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.""?",False, +9990816,Nitric oxide prevents acute kidney failure,3826,"Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.","Is the triple ""Nitric oxide prevents acute kidney failure"" supported by the sentence: ""Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.""?",False, +9464831,Nitric oxide prevents myocardial ischemia,3827,We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.,"Is the triple ""Nitric oxide prevents myocardial ischemia"" supported by the sentence: ""We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.""?",False, +8988568,Nitric oxide prevents chronic obstructive pulmonary disease,3828,Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).,"Is the triple ""Nitric oxide prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).""?",False, +8396830,Nitric oxide prevents cystic fibrosis,3829,"Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.","Is the triple ""Nitric oxide prevents cystic fibrosis"" supported by the sentence: ""Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.""?",False, +8224065,Nitric oxide prevents brain injury,3830,NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.,"Is the triple ""Nitric oxide prevents brain injury"" supported by the sentence: ""NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.""?",False, +8045867,Nitric oxide prevents lung disorder,3831,These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.,"Is the triple ""Nitric oxide prevents lung disorder"" supported by the sentence: ""These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.""?",False, +7996843,Nitric oxide prevents Sepsis,3832,"One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.","Is the triple ""Nitric oxide prevents Sepsis"" supported by the sentence: ""One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.""?",False, +7713281,Nitric oxide prevents respiratory failure,3833,Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.,"Is the triple ""Nitric oxide prevents respiratory failure"" supported by the sentence: ""Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.""?",False, +7103253,Nitric oxide prevents ischemia reperfusion injury,3834,It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.,"Is the triple ""Nitric oxide prevents ischemia reperfusion injury"" supported by the sentence: ""It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.""?",False, +27558971,Nitric oxide exacerbates myocardial ischemia,3835,Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.,"Is the triple ""Nitric oxide exacerbates myocardial ischemia"" supported by the sentence: ""Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.""?",False, +26883794,Nitric oxide exacerbates acute kidney failure,3836,Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.,"Is the triple ""Nitric oxide exacerbates acute kidney failure"" supported by the sentence: ""Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.""?",False, +24530593,Nitric oxide exacerbates ischemia reperfusion injury,3837,"NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.","Is the triple ""Nitric oxide exacerbates ischemia reperfusion injury"" supported by the sentence: ""NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.""?",False, +23305196,Nitric oxide predisposes cystic fibrosis,3838,"It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.","Is the triple ""Nitric oxide predisposes cystic fibrosis"" supported by the sentence: ""It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.""?",False, +18515843,Nitric oxide predisposes malaria,3839,"We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.","Is the triple ""Nitric oxide predisposes malaria"" supported by the sentence: ""We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.""?",False, +17339126,Nitric oxide predisposes stroke disorder,3840,"OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.","Is the triple ""Nitric oxide predisposes stroke disorder"" supported by the sentence: ""OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.""?",False, +17303048,Nitric oxide predisposes brain ischemia,3841,"To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.","Is the triple ""Nitric oxide predisposes brain ischemia"" supported by the sentence: ""To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.""?",False, +16438716,Nitric oxide predisposes respiratory system disorder,3842,Nitric oxide (NO) is now considered an important biomarker for respiratory disease.,"Is the triple ""Nitric oxide predisposes respiratory system disorder"" supported by the sentence: ""Nitric oxide (NO) is now considered an important biomarker for respiratory disease.""?",False, +16061041,Nitric oxide predisposes lung disorder,3843,"As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.","Is the triple ""Nitric oxide predisposes lung disorder"" supported by the sentence: ""As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.""?",False, +15696584,Nitric oxide predisposes chronic obstructive pulmonary disease,3844,"Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.","Is the triple ""Nitric oxide predisposes chronic obstructive pulmonary disease"" supported by the sentence: ""Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.""?",False, +13236015,Nitric oxide predisposes bronchopulmonary dysplasia,3845,Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.,"Is the triple ""Nitric oxide predisposes bronchopulmonary dysplasia"" supported by the sentence: ""Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.""?",False, +12163328,Nitric oxide predisposes acute kidney failure,3846,"However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).","Is the triple ""Nitric oxide predisposes acute kidney failure"" supported by the sentence: ""However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).""?",False, +12068938,Nitric oxide predisposes neuralgia,3847,"During such processes, NO contributes to the development of neuropathic pain.","Is the triple ""Nitric oxide predisposes neuralgia"" supported by the sentence: ""During such processes, NO contributes to the development of neuropathic pain.""?",False, +11569688,Nitric oxide predisposes Premature birth,3848,CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.,"Is the triple ""Nitric oxide predisposes Premature birth"" supported by the sentence: ""CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.""?",False, +9326529,Nitric oxide predisposes brain injury,3849,"Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.","Is the triple ""Nitric oxide predisposes brain injury"" supported by the sentence: ""Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.""?",False, +8098085,Nitric oxide predisposes neoplasm,3850,These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.,"Is the triple ""Nitric oxide predisposes neoplasm"" supported by the sentence: ""These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.""?",False, +7895713,Nitric oxide predisposes pneumonia,3851,"METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).","Is the triple ""Nitric oxide predisposes pneumonia"" supported by the sentence: ""METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).""?",False, +7863118,Nitric oxide predisposes Hypoxemia,3852,"CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.","Is the triple ""Nitric oxide predisposes Hypoxemia"" supported by the sentence: ""CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.""?",False, +7644760,Nitric oxide predisposes anemia,3853,"After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.","Is the triple ""Nitric oxide predisposes anemia"" supported by the sentence: ""After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.""?",False, +7373094,Nitric oxide predisposes ischemia reperfusion injury,3854,Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.,"Is the triple ""Nitric oxide predisposes ischemia reperfusion injury"" supported by the sentence: ""Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.""?",False, +7119398,Nitric oxide predisposes Inflammation,3855,Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.,"Is the triple ""Nitric oxide predisposes Inflammation"" supported by the sentence: ""Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.""?",False, +18948956,CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome,3856,"OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).","Is the triple ""CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome"" supported by the sentence: ""OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).""?",False, +10437081,CHORIONIC GONADOTROPIN related to hypogonadism,3857,[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].,"Is the triple ""CHORIONIC GONADOTROPIN related to hypogonadism"" supported by the sentence: ""[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].""?",False, +10427260,CHORIONIC GONADOTROPIN related to infertility disorder,3858,[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].,"Is the triple ""CHORIONIC GONADOTROPIN related to infertility disorder"" supported by the sentence: ""[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].""?",False, +25953720,CHORIONIC GONADOTROPIN causes infertility disorder,3859,[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].,"Is the triple ""CHORIONIC GONADOTROPIN causes infertility disorder"" supported by the sentence: ""[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].""?",False, +12680602,CHORIONIC GONADOTROPIN causes Pregnancy,3860,Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.,"Is the triple ""CHORIONIC GONADOTROPIN causes Pregnancy"" supported by the sentence: ""Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.""?",False, +19382665,CHORIONIC GONADOTROPIN affects Pregnancy,3861,"Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.","Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.""?",False, +10661395,CHORIONIC GONADOTROPIN affects Pregnancy,3862,Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.,"Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.""?",False, +11878666,CHORIONIC GONADOTROPIN produces Pregnancy,3863,Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.,"Is the triple ""CHORIONIC GONADOTROPIN produces Pregnancy"" supported by the sentence: ""Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.""?",False, +19257969,Triclosan causes allergic disease,3864,Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.,"Is the triple ""Triclosan causes allergic disease"" supported by the sentence: ""Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.""?",False, +17886883,Triclosan affects gingivitis,3865,A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.,"Is the triple ""Triclosan affects gingivitis"" supported by the sentence: ""A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.""?",False, +9651026,Triclosan disrupts gingivitis,3866,"It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.","Is the triple ""Triclosan disrupts gingivitis"" supported by the sentence: ""It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.""?",False, +16053270,Triclosan prevents allergic disease,3867,"Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.","Is the triple ""Triclosan prevents allergic disease"" supported by the sentence: ""Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.""?",False, +20585436,Povidone iodine affects stomatitis,3868,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Povidone iodine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, +22182083,Povidone iodine prevents Infection,3869,"Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.","Is the triple ""Povidone iodine prevents Infection"" supported by the sentence: ""Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.""?",False, +22061199,Povidone iodine prevents dental caries,3870,"OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.","Is the triple ""Povidone iodine prevents dental caries"" supported by the sentence: ""OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.""?",False, +20053240,Povidone iodine prevents keratitis,3871,"The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.","Is the triple ""Povidone iodine prevents keratitis"" supported by the sentence: ""The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.""?",False, +25268747,Vinblastine related to acute myeloid leukemia,3872,Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.,"Is the triple ""Vinblastine related to acute myeloid leukemia"" supported by the sentence: ""Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.""?",False, +24601120,Vinblastine related to leukemia,3873,Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.,"Is the triple ""Vinblastine related to leukemia"" supported by the sentence: ""Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.""?",False, +17518639,Vinblastine related to testicular cancer,3874,"Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.","Is the triple ""Vinblastine related to testicular cancer"" supported by the sentence: ""Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.""?",False, +11295996,Vinblastine related to melanoma,3875,"The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.","Is the triple ""Vinblastine related to melanoma"" supported by the sentence: ""The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.""?",False, +10629211,Vinblastine related to castration-resistant prostate carcinoma,3876,CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.,"Is the triple ""Vinblastine related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.""?",False, +9405598,Vinblastine related to glioma,3877,The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.,"Is the triple ""Vinblastine related to glioma"" supported by the sentence: ""The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.""?",False, +8887641,Vinblastine related to neoplasm,3878,"Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.","Is the triple ""Vinblastine related to neoplasm"" supported by the sentence: ""Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.""?",False, +8831546,Vinblastine related to renal cell carcinoma,3879,Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.,"Is the triple ""Vinblastine related to renal cell carcinoma"" supported by the sentence: ""Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.""?",False, +8248825,Vinblastine related to lymphoma,3880,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Vinblastine related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, +8201846,Vinblastine related to Langerhans cell histiocytosis,3881,[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].,"Is the triple ""Vinblastine related to Langerhans cell histiocytosis"" supported by the sentence: ""[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].""?",False, +7111310,Vinblastine related to Hodgkins lymphoma,3882,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Vinblastine related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, +22913920,Vinblastine causes neoplasm,3883,"Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.","Is the triple ""Vinblastine causes neoplasm"" supported by the sentence: ""Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.""?",False, +14498052,Vinblastine affects Langerhans cell histiocytosis,3884,"Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.","Is the triple ""Vinblastine affects Langerhans cell histiocytosis"" supported by the sentence: ""Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.""?",False, +12889760,Vinblastine affects renal cell carcinoma,3885,"In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.","Is the triple ""Vinblastine affects renal cell carcinoma"" supported by the sentence: ""In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.""?",False, +11723511,Vinblastine affects neoplasm,3886,"By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.","Is the triple ""Vinblastine affects neoplasm"" supported by the sentence: ""By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.""?",False, +19032862,Vinblastine disrupts neoplasm,3887,We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.,"Is the triple ""Vinblastine disrupts neoplasm"" supported by the sentence: ""We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.""?",False, +26195658,Desacetylvinblastine amide related to lymphoma,3888,Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.,"Is the triple ""Desacetylvinblastine amide related to lymphoma"" supported by the sentence: ""Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.""?",False, +26116904,Desacetylvinblastine amide related to acute lymphoblastic leukemia,3889,"Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.","Is the triple ""Desacetylvinblastine amide related to acute lymphoblastic leukemia"" supported by the sentence: ""Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.""?",False, +25980030,Desacetylvinblastine amide related to small cell lung carcinoma,3890,"Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.","Is the triple ""Desacetylvinblastine amide related to small cell lung carcinoma"" supported by the sentence: ""Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.""?",False, +26313629,Desacetylvinblastine amide affects neoplasm,3891,Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).,"Is the triple ""Desacetylvinblastine amide affects neoplasm"" supported by the sentence: ""Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).""?",False, +26201212,Desacetylvinblastine amide affects acute lymphoblastic leukemia,3892,A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.,"Is the triple ""Desacetylvinblastine amide affects acute lymphoblastic leukemia"" supported by the sentence: ""A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.""?",False, +26302410,Desacetylvinblastine amide prevents neoplasm,3893,"No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.","Is the triple ""Desacetylvinblastine amide prevents neoplasm"" supported by the sentence: ""No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.""?",False, +25951740,Diazoxide causes hyperinsulinism,3894,"[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].","Is the triple ""Diazoxide causes hyperinsulinism"" supported by the sentence: ""[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].""?",False, +17059197,Diazoxide causes hypoglycemia,3895,CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.,"Is the triple ""Diazoxide causes hypoglycemia"" supported by the sentence: ""CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.""?",False, +25817473,Diazoxide affects hypertensive disorder,3896,The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.,"Is the triple ""Diazoxide affects hypertensive disorder"" supported by the sentence: ""The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.""?",False, +20202762,Diazoxide affects obesity disorder,3897,"Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.","Is the triple ""Diazoxide affects obesity disorder"" supported by the sentence: ""Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.""?",False, +11393233,Diazoxide affects hyperinsulinism,3898,Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).,"Is the triple ""Diazoxide affects hyperinsulinism"" supported by the sentence: ""Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).""?",False, +8184004,Diazoxide affects hypoglycemia,3899,"An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.","Is the triple ""Diazoxide affects hypoglycemia"" supported by the sentence: ""An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.""?",False, +9572369,Diazoxide disrupts hyperinsulinism,3900,"CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.","Is the triple ""Diazoxide disrupts hyperinsulinism"" supported by the sentence: ""CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.""?",False, +26286810,Diazoxide prevents hypoglycemia,3901,Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.,"Is the triple ""Diazoxide prevents hypoglycemia"" supported by the sentence: ""Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.""?",False, +22404640,Diazoxide prevents hypertensive disorder,3902,Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.,"Is the triple ""Diazoxide prevents hypertensive disorder"" supported by the sentence: ""Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.""?",False, +19200973,Diazoxide prevents obesity disorder,3903,OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.,"Is the triple ""Diazoxide prevents obesity disorder"" supported by the sentence: ""OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.""?",False, +16737667,Diazoxide predisposes hypoglycemia,3904,Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.,"Is the triple ""Diazoxide predisposes hypoglycemia"" supported by the sentence: ""Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.""?",False, +14267417,Pantoprazole affects gastroesophageal reflux disease,3905,Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).,"Is the triple ""Pantoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).""?",False, +12160514,Pantoprazole prevents active peptic ulcer disease,3906,"Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.","Is the triple ""Pantoprazole prevents active peptic ulcer disease"" supported by the sentence: ""Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.""?",False, +8423273,Pantoprazole prevents peptic ulcer disease,3907,"Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.","Is the triple ""Pantoprazole prevents peptic ulcer disease"" supported by the sentence: ""Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.""?",False, +7509578,Pantoprazole prevents ulcer disease,3908,"In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.","Is the triple ""Pantoprazole prevents ulcer disease"" supported by the sentence: ""In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.""?",False, +21088628,Pantoprazole predisposes active peptic ulcer disease,3909,"Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.","Is the triple ""Pantoprazole predisposes active peptic ulcer disease"" supported by the sentence: ""Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.""?",False, +20047688,Lansoprazole causes gastric ulcer,3910,"AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.","Is the triple ""Lansoprazole causes gastric ulcer"" supported by the sentence: ""AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.""?",False, +26544602,Lansoprazole affects peptic ulcer disease,3911,Effect of lansoprazole on peptic ulcers.,"Is the triple ""Lansoprazole affects peptic ulcer disease"" supported by the sentence: ""Effect of lansoprazole on peptic ulcers.""?",False, +11547923,Lansoprazole affects gastroesophageal reflux disease,3912,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Lansoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, +10008124,Lansoprazole affects peptic esophagitis,3913,"When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.","Is the triple ""Lansoprazole affects peptic esophagitis"" supported by the sentence: ""When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.""?",False, +7314434,Lansoprazole affects Helicobacter pylori infectious disease,3914,"Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.","Is the triple ""Lansoprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.""?",False, +9466998,Lansoprazole disrupts gastroesophageal reflux disease,3915,"In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).","Is the triple ""Lansoprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).""?",False, +20033093,Lansoprazole prevents peptic ulcer disease,3916,"CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.","Is the triple ""Lansoprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.""?",False, +15339719,Lansoprazole prevents duodenal ulcer,3917,"The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.","Is the triple ""Lansoprazole prevents duodenal ulcer"" supported by the sentence: ""The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.""?",False, +9335785,Lansoprazole prevents gastric ulcer,3918,"CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.","Is the triple ""Lansoprazole prevents gastric ulcer"" supported by the sentence: ""CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.""?",False, +8183428,Lansoprazole prevents gastroesophageal reflux disease,3919,"In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.","Is the triple ""Lansoprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.""?",False, +27664803,Lansoprazole exacerbates gastritis,3920,RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.,"Is the triple ""Lansoprazole exacerbates gastritis"" supported by the sentence: ""RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.""?",False, +10008126,Lansoprazole predisposes gastroesophageal reflux disease,3921,AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.,"Is the triple ""Lansoprazole predisposes gastroesophageal reflux disease"" supported by the sentence: ""AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.""?",False, +10345128,Omeprazole subclass of Omeprazole sulfone,3922,"The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.","Is the triple ""Omeprazole subclass of Omeprazole sulfone"" supported by the sentence: ""The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.""?",False, +8512321,Omeprazole subclass of Hydroxyomeprazole,3923,"The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.","Is the triple ""Omeprazole subclass of Hydroxyomeprazole"" supported by the sentence: ""The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.""?",False, +27115212,Omeprazole related to Omeprazole sulfone,3924,"Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.","Is the triple ""Omeprazole related to Omeprazole sulfone"" supported by the sentence: ""Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.""?",False, +12365583,Omeprazole related to gastric ulcer,3925,Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?,"Is the triple ""Omeprazole related to gastric ulcer"" supported by the sentence: ""Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?""?",False, +7744216,Omeprazole related to Hydroxyomeprazole,3926,"Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.","Is the triple ""Omeprazole related to Hydroxyomeprazole"" supported by the sentence: ""Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.""?",False, +26722672,Omeprazole physically interacts with Omeprazole sulfone,3927,"The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.","Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.""?",False, +9932953,Omeprazole physically interacts with Hydroxyomeprazole,3928,"Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).","Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).""?",False, +22198908,Omeprazole physically interacts with Omeprazole sulfone,3929,Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.,"Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.""?",False, +13085286,Omeprazole physically interacts with Hydroxyomeprazole,3930,The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.,"Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.""?",False, +27703677,Omeprazole causes anemia,3931,"Pyrexia, anaemia and acute renal failure secondary to omeprazole.","Is the triple ""Omeprazole causes anemia"" supported by the sentence: ""Pyrexia, anaemia and acute renal failure secondary to omeprazole.""?",False, +27298440,Omeprazole causes Hemorrhage,3932,"Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.","Is the triple ""Omeprazole causes Hemorrhage"" supported by the sentence: ""Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.""?",False, +24514538,Omeprazole causes peptic ulcer disease,3933,Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.,"Is the triple ""Omeprazole causes peptic ulcer disease"" supported by the sentence: ""Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.""?",False, +19641302,Omeprazole causes gastroesophageal reflux disease,3934,"The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.","Is the triple ""Omeprazole causes gastroesophageal reflux disease"" supported by the sentence: ""The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.""?",False, +15956000,Omeprazole causes esophagitis,3935,"Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.","Is the triple ""Omeprazole causes esophagitis"" supported by the sentence: ""Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.""?",False, +12187782,Omeprazole causes ulcer disease,3936,"Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.","Is the triple ""Omeprazole causes ulcer disease"" supported by the sentence: ""Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.""?",False, +11135889,Omeprazole causes injury,3937,"DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.","Is the triple ""Omeprazole causes injury"" supported by the sentence: ""DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.""?",False, +10813876,Omeprazole causes Cough,3938,Omeprazole-induced intractable cough.,"Is the triple ""Omeprazole causes Cough"" supported by the sentence: ""Omeprazole-induced intractable cough.""?",False, +8871402,Omeprazole causes gastric ulcer,3939,"Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.","Is the triple ""Omeprazole causes gastric ulcer"" supported by the sentence: ""Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.""?",False, +7272148,Omeprazole causes duodenal ulcer,3940,"Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.","Is the triple ""Omeprazole causes duodenal ulcer"" supported by the sentence: ""Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.""?",False, +27758339,Omeprazole affects Zollinger-Ellison syndrome,3941,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects Zollinger-Ellison syndrome"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, +27758338,Omeprazole affects peptic ulcer disease,3942,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, +27758337,Omeprazole affects peptic esophagitis,3943,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, +27733079,Omeprazole affects peptic esophagitis,3944,The effect of treating reflux oesophagitis with omeprazole on quality of life.,"Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""The effect of treating reflux oesophagitis with omeprazole on quality of life.""?",False, +27346919,Omeprazole affects peptic ulcer disease,3945,[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].,"Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].""?",False, +22440533,Omeprazole affects anemia,3946,Prolonged use of omeprazole may involve in inducing anemia.,"Is the triple ""Omeprazole affects anemia"" supported by the sentence: ""Prolonged use of omeprazole may involve in inducing anemia.""?",False, +18634760,Omeprazole affects Pain,3947,"Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.","Is the triple ""Omeprazole affects Pain"" supported by the sentence: ""Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.""?",False, +17967745,Omeprazole affects injury,3948,Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.,"Is the triple ""Omeprazole affects injury"" supported by the sentence: ""Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.""?",False, +12114858,Omeprazole affects ulcer disease,3949,"Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.""?",False, +11576921,Omeprazole affects Hydroxyomeprazole,3950,CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.""?",False, +10321262,Omeprazole affects duodenal ulcer,3951,"46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.","Is the triple ""Omeprazole affects duodenal ulcer"" supported by the sentence: ""46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.""?",False, +9976497,Omeprazole affects gastric ulcer,3952,A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.,"Is the triple ""Omeprazole affects gastric ulcer"" supported by the sentence: ""A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.""?",False, +8694897,Omeprazole affects Helicobacter pylori infectious disease,3953,"The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.","Is the triple ""Omeprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.""?",False, +8349380,Omeprazole affects Hemorrhage,3954,"CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.","Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.""?",False, +8349375,Omeprazole affects Hemorrhage,3955,Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, +7653505,Omeprazole affects gastroesophageal reflux disease,3956,The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.,"Is the triple ""Omeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.""?",False, +7572363,Omeprazole affects ulcer disease,3957,"Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".""?",False, +14345083,Omeprazole affects Hydroxyomeprazole,3958,The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.""?",False, +26726289,Omeprazole disrupts gastroesophageal reflux disease,3959,"A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.","Is the triple ""Omeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.""?",False, +26000029,Omeprazole disrupts Zollinger-Ellison syndrome,3960,Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.,"Is the triple ""Omeprazole disrupts Zollinger-Ellison syndrome"" supported by the sentence: ""Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.""?",False, +20129793,Omeprazole disrupts Barrett esophagus,3961,"Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.","Is the triple ""Omeprazole disrupts Barrett esophagus"" supported by the sentence: ""Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.""?",False, +19299462,Omeprazole disrupts active peptic ulcer disease,3962,"The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.","Is the triple ""Omeprazole disrupts active peptic ulcer disease"" supported by the sentence: ""The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.""?",False, +15524012,Omeprazole disrupts peptic ulcer disease,3963,Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.,"Is the triple ""Omeprazole disrupts peptic ulcer disease"" supported by the sentence: ""Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.""?",False, +13078646,Omeprazole disrupts ulcer disease,3964,"The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.","Is the triple ""Omeprazole disrupts ulcer disease"" supported by the sentence: ""The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.""?",False, +10891179,Omeprazole disrupts gastric ulcer,3965,"POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.","Is the triple ""Omeprazole disrupts gastric ulcer"" supported by the sentence: ""POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.""?",False, +10776897,Omeprazole disrupts duodenal ulcer,3966,"(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.","Is the triple ""Omeprazole disrupts duodenal ulcer"" supported by the sentence: ""(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.""?",False, +8884340,Omeprazole disrupts esophagitis,3967,"The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).","Is the triple ""Omeprazole disrupts esophagitis"" supported by the sentence: ""The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).""?",False, +27690262,Omeprazole prevents Helicobacter pylori infectious disease,3968,"To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.","Is the triple ""Omeprazole prevents Helicobacter pylori infectious disease"" supported by the sentence: ""To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.""?",False, +27025148,Omeprazole prevents Cough,3969,"Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.","Is the triple ""Omeprazole prevents Cough"" supported by the sentence: ""Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.""?",False, +26715213,Omeprazole prevents Pain,3970,Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.,"Is the triple ""Omeprazole prevents Pain"" supported by the sentence: ""Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.""?",False, +16929638,Omeprazole prevents esophagitis,3971,"Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.","Is the triple ""Omeprazole prevents esophagitis"" supported by the sentence: ""Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.""?",False, +15601042,Omeprazole prevents active peptic ulcer disease,3972,Omeprazole even can decrease gastro-intestinal bleeding in those patients.,"Is the triple ""Omeprazole prevents active peptic ulcer disease"" supported by the sentence: ""Omeprazole even can decrease gastro-intestinal bleeding in those patients.""?",False, +9292674,Omeprazole prevents peptic ulcer disease,3973,"CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.","Is the triple ""Omeprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.""?",False, +8884338,Omeprazole prevents peptic esophagitis,3974,IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.,"Is the triple ""Omeprazole prevents peptic esophagitis"" supported by the sentence: ""IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.""?",False, +8341772,Omeprazole prevents duodenal ulcer,3975,The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].,"Is the triple ""Omeprazole prevents duodenal ulcer"" supported by the sentence: ""The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].""?",False, +8169375,Omeprazole prevents injury,3976,"The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).","Is the triple ""Omeprazole prevents injury"" supported by the sentence: ""The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).""?",False, +7646984,Omeprazole prevents gastric ulcer,3977,Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.,"Is the triple ""Omeprazole prevents gastric ulcer"" supported by the sentence: ""Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.""?",False, +7653510,Omeprazole prevents gastroesophageal reflux disease,3978,"CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.","Is the triple ""Omeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.""?",False, +7332307,Omeprazole prevents ulcer disease,3979,Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.,"Is the triple ""Omeprazole prevents ulcer disease"" supported by the sentence: ""Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.""?",False, +24752030,Omeprazole predisposes type 2 diabetes mellitus,3980,"Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.","Is the triple ""Omeprazole predisposes type 2 diabetes mellitus"" supported by the sentence: ""Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.""?",False, +21309680,Omeprazole predisposes melanoma,3981,"The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.","Is the triple ""Omeprazole predisposes melanoma"" supported by the sentence: ""The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.""?",False, +20838741,Omeprazole predisposes Barrett esophagus,3982,"Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.","Is the triple ""Omeprazole predisposes Barrett esophagus"" supported by the sentence: ""Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.""?",False, +12649375,Rabeprazole affects infectious disease,3983,"METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).","Is the triple ""Rabeprazole affects infectious disease"" supported by the sentence: ""METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).""?",False, +11547924,Rabeprazole affects gastroesophageal reflux disease,3984,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Rabeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, +15461842,Rabeprazole disrupts gastroesophageal reflux disease,3985,CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.,"Is the triple ""Rabeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.""?",False, +16244495,Rabeprazole prevents peptic ulcer disease,3986,"We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.","Is the triple ""Rabeprazole prevents peptic ulcer disease"" supported by the sentence: ""We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.""?",False, +15354267,Rabeprazole prevents active peptic ulcer disease,3987,The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.,"Is the triple ""Rabeprazole prevents active peptic ulcer disease"" supported by the sentence: ""The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.""?",False, +8397732,Rabeprazole prevents gastroesophageal reflux disease,3988,RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).,"Is the triple ""Rabeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).""?",False, +23526790,Esomeprazole causes active peptic ulcer disease,3989,"Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.","Is the triple ""Esomeprazole causes active peptic ulcer disease"" supported by the sentence: ""Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.""?",False, +20333475,Esomeprazole causes preeclampsia,3990,We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.,"Is the triple ""Esomeprazole causes preeclampsia"" supported by the sentence: ""We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.""?",False, +15271081,Esomeprazole causes gastric ulcer,3991,The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.,"Is the triple ""Esomeprazole causes gastric ulcer"" supported by the sentence: ""The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.""?",False, +22638872,Esomeprazole affects neoplasm,3992,"Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.","Is the triple ""Esomeprazole affects neoplasm"" supported by the sentence: ""Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.""?",False, +20180848,Esomeprazole affects preeclampsia,3993,Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.,"Is the triple ""Esomeprazole affects preeclampsia"" supported by the sentence: ""Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.""?",False, +19360632,Esomeprazole affects ulcer disease,3994,Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.,"Is the triple ""Esomeprazole affects ulcer disease"" supported by the sentence: ""Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.""?",False, +18357402,Esomeprazole affects dyspepsia,3995,"Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.","Is the triple ""Esomeprazole affects dyspepsia"" supported by the sentence: ""Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.""?",False, +14247859,Esomeprazole affects gastric ulcer,3996,"In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.","Is the triple ""Esomeprazole affects gastric ulcer"" supported by the sentence: ""In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.""?",False, +12902689,Esomeprazole affects Hemorrhage,3997,The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, +12902688,Esomeprazole affects Hemorrhage,3998,Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, +12527967,Esomeprazole affects gastroesophageal reflux disease,3999,CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.,"Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.""?",False, +12015567,Esomeprazole affects gastroesophageal reflux disease,4000,"This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.","Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.""?",False, +10805094,Esomeprazole disrupts gastroesophageal reflux disease,4001,"The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.","Is the triple ""Esomeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.""?",False, +15938697,Esomeprazole prevents gastric ulcer,4002,"Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.","Is the triple ""Esomeprazole prevents gastric ulcer"" supported by the sentence: ""Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.""?",False, +14015294,Esomeprazole prevents gastroesophageal reflux disease,4003,CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.,"Is the triple ""Esomeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.""?",False, +13576722,Esomeprazole prevents peptic ulcer disease,4004,Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.,"Is the triple ""Esomeprazole prevents peptic ulcer disease"" supported by the sentence: ""Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.""?",False, +12321750,Esomeprazole prevents ulcer disease,4005,"CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.","Is the triple ""Esomeprazole prevents ulcer disease"" supported by the sentence: ""CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.""?",False, +10396538,Roflumilast related to asthma,4006,Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.,"Is the triple ""Roflumilast related to asthma"" supported by the sentence: ""Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.""?",False, +21017284,Roflumilast causes chronic obstructive pulmonary disease,4007,"Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.","Is the triple ""Roflumilast causes chronic obstructive pulmonary disease"" supported by the sentence: ""Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.""?",False, +21116198,Roflumilast affects obesity disorder,4008,"Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.","Is the triple ""Roflumilast affects obesity disorder"" supported by the sentence: ""Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.""?",False, +12290110,Roflumilast affects chronic obstructive pulmonary disease,4009,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects chronic obstructive pulmonary disease"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, +12290109,Roflumilast affects asthma,4010,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects asthma"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, +22432515,Roflumilast disrupts schizophrenia,4011,"CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.","Is the triple ""Roflumilast disrupts schizophrenia"" supported by the sentence: ""CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.""?",False, +24502817,Roflumilast prevents obesity disorder,4012,"RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.","Is the triple ""Roflumilast prevents obesity disorder"" supported by the sentence: ""RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.""?",False, +17763098,Roflumilast prevents diabetic kidney disease,4013,Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.,"Is the triple ""Roflumilast prevents diabetic kidney disease"" supported by the sentence: ""Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.""?",False, +15955656,Roflumilast prevents chronic obstructive pulmonary disease,4014,"Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.","Is the triple ""Roflumilast prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.""?",False, +8310806,Meperidine causes Pain,4015,OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.,"Is the triple ""Meperidine causes Pain"" supported by the sentence: ""OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.""?",False, +26434893,Meperidine affects Pain,4016,The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.,"Is the triple ""Meperidine affects Pain"" supported by the sentence: ""The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.""?",False, +18658715,Meperidine affects Pain,4017,"Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.","Is the triple ""Meperidine affects Pain"" supported by the sentence: ""Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.""?",False, +8345324,Meperidine prevents Pain,4018,The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.,"Is the triple ""Meperidine prevents Pain"" supported by the sentence: ""The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.""?",False, +21672389,Ketobemidone affects Pain,4019,"Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.","Is the triple ""Ketobemidone affects Pain"" supported by the sentence: ""Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.""?",False, +11850764,Travoprost related to ocular hypertension,4020,"CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.","Is the triple ""Travoprost related to ocular hypertension"" supported by the sentence: ""CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.""?",False, +12116829,Travoprost physically interacts with prostanoid FP receptor,4021,"PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.","Is the triple ""Travoprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.""?",False, +18294152,Travoprost affects ocular hypertension,4022,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects ocular hypertension"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, +18294151,Travoprost affects glaucoma,4023,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects glaucoma"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, +10166996,Travoprost prevents ocular hypertension,4024,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents ocular hypertension"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, +10166995,Travoprost prevents open-angle glaucoma,4025,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents open-angle glaucoma"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, +17904574,Tafluprost related to glaucoma,4026,Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.,"Is the triple ""Tafluprost related to glaucoma"" supported by the sentence: ""Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.""?",False, +15304153,Tafluprost related to ocular hypertension,4027,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to ocular hypertension"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, +15304152,Tafluprost related to open-angle glaucoma,4028,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to open-angle glaucoma"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, +14941475,Tafluprost physically interacts with prostanoid FP receptor,4029,Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.,"Is the triple ""Tafluprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.""?",False, +14941474,Tafluprost disrupts ocular hypertension,4030,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts ocular hypertension"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, +14941473,Tafluprost disrupts open-angle glaucoma,4031,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts open-angle glaucoma"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, +14231277,Ramelteon affects insomnia,4032,"Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.","Is the triple ""Ramelteon affects insomnia"" supported by the sentence: ""Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.""?",False, +21718213,Ramelteon prevents sleep-wake disorder,4033,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Ramelteon prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, +22873470,Melatonin related to acute kidney failure,4034,"Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.","Is the triple ""Melatonin related to acute kidney failure"" supported by the sentence: ""Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.""?",False, +22002909,Melatonin related to metabolic disease,4035,"Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.","Is the triple ""Melatonin related to metabolic disease"" supported by the sentence: ""Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.""?",False, +21777340,Melatonin related to Cognitive impairment,4036,"Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.","Is the triple ""Melatonin related to Cognitive impairment"" supported by the sentence: ""Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.""?",False, +18920431,Melatonin related to burn,4037,"CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.","Is the triple ""Melatonin related to burn"" supported by the sentence: ""CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.""?",False, +18846352,Melatonin related to skin disorder,4038,And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.,"Is the triple ""Melatonin related to skin disorder"" supported by the sentence: ""And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.""?",False, +18613354,Melatonin related to Neonatal sepsis,4039,Use of melatonin as an adjuvant therapy in neonatal sepsis.,"Is the triple ""Melatonin related to Neonatal sepsis"" supported by the sentence: ""Use of melatonin as an adjuvant therapy in neonatal sepsis.""?",False, +18189253,Melatonin related to necrotizing enterocolitis,4040,"This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.","Is the triple ""Melatonin related to necrotizing enterocolitis"" supported by the sentence: ""This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.""?",False, +17471678,"Melatonin related to dermatitis, atopic",4041,"To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.","Is the triple ""Melatonin related to dermatitis, atopic"" supported by the sentence: ""To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.""?",False, +17103445,Melatonin related to obstructive sleep apnea syndrome,4042,Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?,"Is the triple ""Melatonin related to obstructive sleep apnea syndrome"" supported by the sentence: ""Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?""?",False, +16423098,Melatonin related to periodontitis,4043,Previous studies reported decreased salivary and serum melatonin levels in periodontitis.,"Is the triple ""Melatonin related to periodontitis"" supported by the sentence: ""Previous studies reported decreased salivary and serum melatonin levels in periodontitis.""?",False, +16022569,Melatonin related to metabolic syndrome X,4044,"In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.","Is the triple ""Melatonin related to metabolic syndrome X"" supported by the sentence: ""In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.""?",False, +15882605,Melatonin related to enuresis,4045,"Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.","Is the triple ""Melatonin related to enuresis"" supported by the sentence: ""Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.""?",False, +15709123,Melatonin related to fibromyalgia,4046,Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.,"Is the triple ""Melatonin related to fibromyalgia"" supported by the sentence: ""Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.""?",False, +15665905,"Melatonin related to attention deficit hyperactivity disorder, inattentive type",4047,These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.,"Is the triple ""Melatonin related to attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.""?",False, +14933527,Melatonin related to autism spectrum disorder,4048,"Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.","Is the triple ""Melatonin related to autism spectrum disorder"" supported by the sentence: ""Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.""?",False, +14875890,Melatonin related to pervasive developmental disorder,4049,"Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.","Is the triple ""Melatonin related to pervasive developmental disorder"" supported by the sentence: ""Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.""?",False, +14786958,Melatonin related to gastroesophageal reflux disease,4050,The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.,"Is the triple ""Melatonin related to gastroesophageal reflux disease"" supported by the sentence: ""The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.""?",False, +13857052,Melatonin related to ulcerative colitis,4051,In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.,"Is the triple ""Melatonin related to ulcerative colitis"" supported by the sentence: ""In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.""?",False, +13491215,Melatonin related to diabetes mellitus,4052,(v) Melatonin influences diabetes and associated metabolic disturbances.,"Is the triple ""Melatonin related to diabetes mellitus"" supported by the sentence: ""(v) Melatonin influences diabetes and associated metabolic disturbances.""?",False, +13407170,Melatonin related to periodontal disorder,4053,BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.,"Is the triple ""Melatonin related to periodontal disorder"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.""?",False, +13365823,Melatonin related to tooth disorder,4054,"Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.","Is the triple ""Melatonin related to tooth disorder"" supported by the sentence: ""Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.""?",False, +12843346,Melatonin related to melanoma,4055,"Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.","Is the triple ""Melatonin related to melanoma"" supported by the sentence: ""Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.""?",False, +12132104,Melatonin related to irritable bowel syndrome,4056,AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).,"Is the triple ""Melatonin related to irritable bowel syndrome"" supported by the sentence: ""AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).""?",False, +11584899,Melatonin related to brain ischemia,4057,"Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.","Is the triple ""Melatonin related to brain ischemia"" supported by the sentence: ""Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.""?",False, +11533403,Melatonin related to hypertensive disorder,4058,"Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.","Is the triple ""Melatonin related to hypertensive disorder"" supported by the sentence: ""Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.""?",False, +11319171,Melatonin related to Pain,4059,These results suggest a proalgesic role of endogenous melatonin in tonic pain.,"Is the triple ""Melatonin related to Pain"" supported by the sentence: ""These results suggest a proalgesic role of endogenous melatonin in tonic pain.""?",False, +11137637,Melatonin related to essential hypertension,4060,"OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.","Is the triple ""Melatonin related to essential hypertension"" supported by the sentence: ""OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.""?",False, +10685850,Melatonin related to major depressive disorder,4061,"Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.","Is the triple ""Melatonin related to major depressive disorder"" supported by the sentence: ""Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.""?",False, +10528037,Melatonin related to multiple sclerosis,4062,"Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.","Is the triple ""Melatonin related to multiple sclerosis"" supported by the sentence: ""Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.""?",False, +10477010,Melatonin related to non-small cell lung carcinoma,4063,"On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.","Is the triple ""Melatonin related to non-small cell lung carcinoma"" supported by the sentence: ""On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.""?",False, +10371972,Melatonin related to delirium,4064,"Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.","Is the triple ""Melatonin related to delirium"" supported by the sentence: ""Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.""?",False, +10204563,Melatonin related to depressive disorder,4065,"Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.","Is the triple ""Melatonin related to depressive disorder"" supported by the sentence: ""Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.""?",False, +9947492,Melatonin related to myocardial infarction,4066,Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.,"Is the triple ""Melatonin related to myocardial infarction"" supported by the sentence: ""Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.""?",False, +9516882,Melatonin related to Parkinson disease,4067,Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.,"Is the triple ""Melatonin related to Parkinson disease"" supported by the sentence: ""Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.""?",False, +9086006,Melatonin related to ischemia reperfusion injury,4068,"Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.","Is the triple ""Melatonin related to ischemia reperfusion injury"" supported by the sentence: ""Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.""?",False, +9074687,Melatonin related to Sepsis,4069,"These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.","Is the triple ""Melatonin related to Sepsis"" supported by the sentence: ""These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.""?",False, +8867365,Melatonin related to schizophrenia,4070,"CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.","Is the triple ""Melatonin related to schizophrenia"" supported by the sentence: ""CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.""?",False, +8780387,Melatonin related to insomnia,4071,"The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.","Is the triple ""Melatonin related to insomnia"" supported by the sentence: ""The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.""?",False, +8686098,Melatonin related to dementia,4072,OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.,"Is the triple ""Melatonin related to dementia"" supported by the sentence: ""OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.""?",False, +8623112,Melatonin related to migraine disorder,4073,"This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.","Is the triple ""Melatonin related to migraine disorder"" supported by the sentence: ""This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.""?",False, +7795396,Melatonin related to injury,4074,"Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.","Is the triple ""Melatonin related to injury"" supported by the sentence: ""Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.""?",False, +7482169,Melatonin related to neoplasm,4075,Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.,"Is the triple ""Melatonin related to neoplasm"" supported by the sentence: ""Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.""?",False, +7440685,Melatonin related to Fatigue,4076,"Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.","Is the triple ""Melatonin related to Fatigue"" supported by the sentence: ""Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.""?",False, +7185935,Melatonin related to epilepsy,4077,Melatonin in epilepsy: first results of replacement therapy and first clinical results.,"Is the triple ""Melatonin related to epilepsy"" supported by the sentence: ""Melatonin in epilepsy: first results of replacement therapy and first clinical results.""?",False, +7185921,Melatonin related to sleep-wake disorder,4078,Melatonin in circadian sleep disorders in the blind.,"Is the triple ""Melatonin related to sleep-wake disorder"" supported by the sentence: ""Melatonin in circadian sleep disorders in the blind.""?",False, +26987553,Melatonin causes Fatigue,4079,"Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.","Is the triple ""Melatonin causes Fatigue"" supported by the sentence: ""Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.""?",False, +24500836,Melatonin causes anxiety,4080,"Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.","Is the triple ""Melatonin causes anxiety"" supported by the sentence: ""Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.""?",False, +22662368,Melatonin causes dementia,4081,"A chronic melatonin deficiency, with loss of dreams, could cause dementia.","Is the triple ""Melatonin causes dementia"" supported by the sentence: ""A chronic melatonin deficiency, with loss of dreams, could cause dementia.""?",False, +21258564,Melatonin causes multiple sclerosis,4082,"A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.","Is the triple ""Melatonin causes multiple sclerosis"" supported by the sentence: ""A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.""?",False, +19886996,Melatonin causes Cognitive impairment,4083,"However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.","Is the triple ""Melatonin causes Cognitive impairment"" supported by the sentence: ""However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.""?",False, +19573910,Melatonin causes periodontitis,4084,Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.,"Is the triple ""Melatonin causes periodontitis"" supported by the sentence: ""Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.""?",False, +17837306,Melatonin causes metabolic disease,4085,"This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.","Is the triple ""Melatonin causes metabolic disease"" supported by the sentence: ""This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.""?",False, +17714427,Melatonin causes myocardial infarction,4086,The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.,"Is the triple ""Melatonin causes myocardial infarction"" supported by the sentence: ""The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.""?",False, +16705153,Melatonin causes Sepsis,4087,Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.,"Is the triple ""Melatonin causes Sepsis"" supported by the sentence: ""Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.""?",False, +15644359,Melatonin causes gastroesophageal reflux disease,4088,Low levels of melatonin lead to gastroesophageal reflux disease (GERD).,"Is the triple ""Melatonin causes gastroesophageal reflux disease"" supported by the sentence: ""Low levels of melatonin lead to gastroesophageal reflux disease (GERD).""?",False, +14831403,Melatonin causes periodontal disorder,4089,"BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.","Is the triple ""Melatonin causes periodontal disorder"" supported by the sentence: ""BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.""?",False, +14171289,Melatonin causes Parkinson disease,4090,"Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.","Is the triple ""Melatonin causes Parkinson disease"" supported by the sentence: ""Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.""?",False, +14078373,Melatonin causes hypertensive disorder,4091,Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.,"Is the triple ""Melatonin causes hypertensive disorder"" supported by the sentence: ""Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.""?",False, +13896033,Melatonin causes breast neoplasm,4092,"Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.","Is the triple ""Melatonin causes breast neoplasm"" supported by the sentence: ""Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.""?",False, +13361926,Melatonin causes ischemia reperfusion injury,4093,The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.,"Is the triple ""Melatonin causes ischemia reperfusion injury"" supported by the sentence: ""The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.""?",False, +13039360,Melatonin causes epilepsy,4094,"In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.","Is the triple ""Melatonin causes epilepsy"" supported by the sentence: ""In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.""?",False, +12762592,Melatonin causes enuresis,4095,"CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.","Is the triple ""Melatonin causes enuresis"" supported by the sentence: ""CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.""?",False, +12275569,Melatonin causes diabetes mellitus,4096,"Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.","Is the triple ""Melatonin causes diabetes mellitus"" supported by the sentence: ""Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.""?",False, +12071557,Melatonin causes insomnia,4097,"Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.","Is the triple ""Melatonin causes insomnia"" supported by the sentence: ""Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.""?",False, +10432083,Melatonin causes migraine disorder,4098,"The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.","Is the triple ""Melatonin causes migraine disorder"" supported by the sentence: ""The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.""?",False, +10432067,Melatonin causes schizophrenia,4099,"I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.","Is the triple ""Melatonin causes schizophrenia"" supported by the sentence: ""I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.""?",False, +9114525,Melatonin causes neoplasm,4100,"Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.","Is the triple ""Melatonin causes neoplasm"" supported by the sentence: ""Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.""?",False, +8785660,Melatonin causes depressive disorder,4101,The melatonin-induced depression was followed by a slow recovery phase.,"Is the triple ""Melatonin causes depressive disorder"" supported by the sentence: ""The melatonin-induced depression was followed by a slow recovery phase.""?",False, +8291971,Melatonin causes injury,4102,"Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.","Is the triple ""Melatonin causes injury"" supported by the sentence: ""Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.""?",False, +25620630,Melatonin affects Fatigue,4103,"Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.""?",False, +25259613,Melatonin affects atrial fibrillation,4104,"Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.","Is the triple ""Melatonin affects atrial fibrillation"" supported by the sentence: ""Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.""?",False, +24144792,Melatonin affects myocardial infarction,4105,"RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.","Is the triple ""Melatonin affects myocardial infarction"" supported by the sentence: ""RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.""?",False, +24094187,Melatonin affects major depressive disorder,4106,"A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.","Is the triple ""Melatonin affects major depressive disorder"" supported by the sentence: ""A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.""?",False, +23101890,Melatonin affects periodontitis,4107,The Effect of Melatonin on Periodontitis.,"Is the triple ""Melatonin affects periodontitis"" supported by the sentence: ""The Effect of Melatonin on Periodontitis.""?",False, +22037016,Melatonin affects diabetes mellitus,4108,Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.,"Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.""?",False, +21523229,Melatonin affects anxiety,4109,The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.,"Is the triple ""Melatonin affects anxiety"" supported by the sentence: ""The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.""?",False, +21046382,Melatonin affects non-small cell lung carcinoma,4110,"Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.","Is the triple ""Melatonin affects non-small cell lung carcinoma"" supported by the sentence: ""Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.""?",False, +20888328,Melatonin affects autism spectrum disorder,4111,"In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.","Is the triple ""Melatonin affects autism spectrum disorder"" supported by the sentence: ""In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.""?",False, +18858036,Melatonin affects Cognitive impairment,4112,Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.,"Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.""?",False, +18703578,Melatonin affects Marchiafava-Bignami disease,4113,"The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.","Is the triple ""Melatonin affects Marchiafava-Bignami disease"" supported by the sentence: ""The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.""?",False, +18605461,Melatonin affects Neonatal sepsis,4114,CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.""?",False, +18605459,Melatonin affects Neonatal sepsis,4115,Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.""?",False, +18111864,Melatonin affects Hemorrhage,4116,Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.,"Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.""?",False, +17774103,Melatonin affects fibromyalgia,4117,"Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).","Is the triple ""Melatonin affects fibromyalgia"" supported by the sentence: ""Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).""?",False, +17471677,"Melatonin affects dermatitis, atopic",4118,Alterations of melatonin secretion in atopic eczema.,"Is the triple ""Melatonin affects dermatitis, atopic"" supported by the sentence: ""Alterations of melatonin secretion in atopic eczema.""?",False, +17402992,Melatonin affects Fatigue,4119,"Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.""?",False, +17199486,Melatonin affects Sepsis,4120,Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.,"Is the triple ""Melatonin affects Sepsis"" supported by the sentence: ""Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.""?",False, +17103446,Melatonin affects obstructive sleep apnea syndrome,4121,The data on the involvement of melatonin in OSAS are rare.,"Is the triple ""Melatonin affects obstructive sleep apnea syndrome"" supported by the sentence: ""The data on the involvement of melatonin in OSAS are rare.""?",False, +17112614,Melatonin affects ulcerative colitis,4122,Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.,"Is the triple ""Melatonin affects ulcerative colitis"" supported by the sentence: ""Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.""?",False, +16898660,Melatonin affects Cognitive impairment,4123,"Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.""?",False, +16300651,Melatonin affects depressive disorder,4124,"Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.""?",False, +16293202,Melatonin affects Hemorrhage,4125,"Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.","Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.""?",False, +16189615,Melatonin affects Cognitive impairment,4126,"The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.""?",False, +15390003,Melatonin affects delirium,4127,Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.,"Is the triple ""Melatonin affects delirium"" supported by the sentence: ""Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.""?",False, +14400565,Melatonin affects burn,4128,Effect of melatonin on burn-induced gastric mucosal injury in rats.,"Is the triple ""Melatonin affects burn"" supported by the sentence: ""Effect of melatonin on burn-induced gastric mucosal injury in rats.""?",False, +14333232,Melatonin affects schizophrenia,4129,"""Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.","Is the triple ""Melatonin affects schizophrenia"" supported by the sentence: """"Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.""?",False, +13430046,Melatonin affects epilepsy,4130,"Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.","Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.""?",False, +13158859,Melatonin affects tooth disorder,4131,"RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.","Is the triple ""Melatonin affects tooth disorder"" supported by the sentence: ""RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.""?",False, +12620684,Melatonin affects melanoma,4132,Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.,"Is the triple ""Melatonin affects melanoma"" supported by the sentence: ""Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.""?",False, +12473519,Melatonin affects Parkinson disease,4133,Melatonin secretion has been found to be altered in AD and PD.,"Is the triple ""Melatonin affects Parkinson disease"" supported by the sentence: ""Melatonin secretion has been found to be altered in AD and PD.""?",False, +11739216,Melatonin affects sleep-wake disorder,4134,"To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).","Is the triple ""Melatonin affects sleep-wake disorder"" supported by the sentence: ""To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).""?",False, +11451669,Melatonin affects depressive disorder,4135,"Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.""?",False, +10979770,Melatonin affects insomnia,4136,Potential action of melatonin in insomnia.,"Is the triple ""Melatonin affects insomnia"" supported by the sentence: ""Potential action of melatonin in insomnia.""?",False, +10516034,Melatonin affects Pain,4137,"An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.","Is the triple ""Melatonin affects Pain"" supported by the sentence: ""An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.""?",False, +10432086,Melatonin affects multiple sclerosis,4138,Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.,"Is the triple ""Melatonin affects multiple sclerosis"" supported by the sentence: ""Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.""?",False, +10047665,Melatonin affects hypertensive disorder,4139,Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.,"Is the triple ""Melatonin affects hypertensive disorder"" supported by the sentence: ""Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.""?",False, +9535418,Melatonin affects injury,4140,We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.,"Is the triple ""Melatonin affects injury"" supported by the sentence: ""We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.""?",False, +9364224,Melatonin affects Pain,4141,Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.,"Is the triple ""Melatonin affects Pain"" supported by the sentence: ""Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.""?",False, +9244581,Melatonin affects migraine disorder,4142,"The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.","Is the triple ""Melatonin affects migraine disorder"" supported by the sentence: ""The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.""?",False, +9153135,Melatonin affects diabetes mellitus,4143,"Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.","Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.""?",False, +9143737,Melatonin affects epilepsy,4144,Melatonin effect on seizures in children with severe neurologic deficit disorders.,"Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Melatonin effect on seizures in children with severe neurologic deficit disorders.""?",False, +9114510,Melatonin affects ischemia reperfusion injury,4145,This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.,"Is the triple ""Melatonin affects ischemia reperfusion injury"" supported by the sentence: ""This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.""?",False, +8993003,Melatonin affects neoplasm,4146,"However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.","Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.""?",False, +8720758,Melatonin affects breast neoplasm,4147,We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.,"Is the triple ""Melatonin affects breast neoplasm"" supported by the sentence: ""We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.""?",False, +8108047,Melatonin affects depressive disorder,4148,"Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.""?",False, +7564928,Melatonin affects neoplasm,4149,Melatonin also affects tumorigenesis and tumor development.,"Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""Melatonin also affects tumorigenesis and tumor development.""?",False, +7382212,Melatonin affects brain ischemia,4150,These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.,"Is the triple ""Melatonin affects brain ischemia"" supported by the sentence: ""These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.""?",False, +26765396,Melatonin produces epilepsy,4151,Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.,"Is the triple ""Melatonin produces epilepsy"" supported by the sentence: ""Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.""?",False, +22867260,Melatonin produces diabetes mellitus,4152,"Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.","Is the triple ""Melatonin produces diabetes mellitus"" supported by the sentence: ""Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.""?",False, +18240585,Melatonin produces ulcerative colitis,4153,METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.,"Is the triple ""Melatonin produces ulcerative colitis"" supported by the sentence: ""METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.""?",False, +17207380,Melatonin produces autism spectrum disorder,4154,"Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.","Is the triple ""Melatonin produces autism spectrum disorder"" supported by the sentence: ""Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.""?",False, +17051558,Melatonin produces depressive disorder,4155,These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.,"Is the triple ""Melatonin produces depressive disorder"" supported by the sentence: ""These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.""?",False, +16192357,Melatonin produces sleep-wake disorder,4156,"The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.","Is the triple ""Melatonin produces sleep-wake disorder"" supported by the sentence: ""The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.""?",False, +13817260,Melatonin produces Parkinson disease,4157,"Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.","Is the triple ""Melatonin produces Parkinson disease"" supported by the sentence: ""Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.""?",False, +11388402,Melatonin produces neoplasm,4158,"The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.","Is the triple ""Melatonin produces neoplasm"" supported by the sentence: ""The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.""?",False, +9153153,Melatonin produces hypertensive disorder,4159,"Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.","Is the triple ""Melatonin produces hypertensive disorder"" supported by the sentence: ""Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.""?",False, +8191029,Melatonin produces breast neoplasm,4160,"The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.","Is the triple ""Melatonin produces breast neoplasm"" supported by the sentence: ""The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.""?",False, +24623673,Melatonin disrupts atrial fibrillation,4161,Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).,"Is the triple ""Melatonin disrupts atrial fibrillation"" supported by the sentence: ""Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).""?",False, +24220852,Melatonin disrupts metabolic disease,4162,"Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.","Is the triple ""Melatonin disrupts metabolic disease"" supported by the sentence: ""Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.""?",False, +22817547,Melatonin disrupts anxiety,4163,"Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.","Is the triple ""Melatonin disrupts anxiety"" supported by the sentence: ""Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.""?",False, +20966258,Melatonin disrupts Cognitive impairment,4164,"Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.","Is the triple ""Melatonin disrupts Cognitive impairment"" supported by the sentence: ""Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.""?",False, +20623050,"Melatonin disrupts attention deficit hyperactivity disorder, inattentive type",4165,Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.,"Is the triple ""Melatonin disrupts attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.""?",False, +19958338,Melatonin disrupts multiple sclerosis,4166,Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.,"Is the triple ""Melatonin disrupts multiple sclerosis"" supported by the sentence: ""Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.""?",False, +18007482,Melatonin disrupts Sepsis,4167,"Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.","Is the triple ""Melatonin disrupts Sepsis"" supported by the sentence: ""Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.""?",False, +18002672,Melatonin disrupts Pain,4168,STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.,"Is the triple ""Melatonin disrupts Pain"" supported by the sentence: ""STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.""?",False, +16753621,Melatonin disrupts sleep-wake disorder,4169,"Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.","Is the triple ""Melatonin disrupts sleep-wake disorder"" supported by the sentence: ""Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.""?",False, +14914180,Melatonin disrupts melanoma,4170,"Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.","Is the triple ""Melatonin disrupts melanoma"" supported by the sentence: ""Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.""?",False, +14617999,"Melatonin disrupts dermatitis, atopic",4171,"Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.","Is the triple ""Melatonin disrupts dermatitis, atopic"" supported by the sentence: ""Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.""?",False, +13855513,Melatonin disrupts Hemorrhage,4172,"Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.","Is the triple ""Melatonin disrupts Hemorrhage"" supported by the sentence: ""Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.""?",False, +10721769,Melatonin disrupts depressive disorder,4173,Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.,"Is the triple ""Melatonin disrupts depressive disorder"" supported by the sentence: ""Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.""?",False, +10333555,Melatonin disrupts injury,4174,"Moreover, melatonin diminished iron-induced oxidative injury.","Is the triple ""Melatonin disrupts injury"" supported by the sentence: ""Moreover, melatonin diminished iron-induced oxidative injury.""?",False, +10294227,Melatonin disrupts breast neoplasm,4175,"During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.","Is the triple ""Melatonin disrupts breast neoplasm"" supported by the sentence: ""During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.""?",False, +10070181,Melatonin disrupts brain ischemia,4176,"Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.","Is the triple ""Melatonin disrupts brain ischemia"" supported by the sentence: ""Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.""?",False, +10008170,Melatonin disrupts Marchiafava-Bignami disease,4177,"Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.","Is the triple ""Melatonin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.""?",False, +8932328,Melatonin disrupts epilepsy,4178,"Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.","Is the triple ""Melatonin disrupts epilepsy"" supported by the sentence: ""Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.""?",False, +7916082,Melatonin disrupts ischemia reperfusion injury,4179,"Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.","Is the triple ""Melatonin disrupts ischemia reperfusion injury"" supported by the sentence: ""Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.""?",False, +7545973,Melatonin disrupts neoplasm,4180,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin disrupts neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, +24902716,Melatonin prevents stomatitis,4181,"MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).","Is the triple ""Melatonin prevents stomatitis"" supported by the sentence: ""MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).""?",False, +24687342,Melatonin prevents essential hypertension,4182,The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.,"Is the triple ""Melatonin prevents essential hypertension"" supported by the sentence: ""The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.""?",False, +24623674,Melatonin prevents atrial fibrillation,4183,"Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.","Is the triple ""Melatonin prevents atrial fibrillation"" supported by the sentence: ""Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.""?",False, +24368351,Melatonin prevents acute kidney failure,4184,"Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.","Is the triple ""Melatonin prevents acute kidney failure"" supported by the sentence: ""Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.""?",False, +23824121,Melatonin prevents dementia,4185,"While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.","Is the triple ""Melatonin prevents dementia"" supported by the sentence: ""While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.""?",False, +23122960,Melatonin prevents Cognitive impairment,4186,Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.,"Is the triple ""Melatonin prevents Cognitive impairment"" supported by the sentence: ""Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.""?",False, +22817548,Melatonin prevents anxiety,4187,"Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).","Is the triple ""Melatonin prevents anxiety"" supported by the sentence: ""Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).""?",False, +21718214,Melatonin prevents sleep-wake disorder,4188,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Melatonin prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, +20260777,Melatonin prevents Pain,4189,"In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).","Is the triple ""Melatonin prevents Pain"" supported by the sentence: ""In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).""?",False, +19640170,Melatonin prevents aortic aneurysm,4190,This study examined whether melatonin has protective or therapeutic effects against AAAs.,"Is the triple ""Melatonin prevents aortic aneurysm"" supported by the sentence: ""This study examined whether melatonin has protective or therapeutic effects against AAAs.""?",False, +18396849,Melatonin prevents Sepsis,4191,Previous studies have suggested that melatonin is protective during sepsis.,"Is the triple ""Melatonin prevents Sepsis"" supported by the sentence: ""Previous studies have suggested that melatonin is protective during sepsis.""?",False, +18141997,Melatonin prevents metabolic disease,4192,Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.,"Is the triple ""Melatonin prevents metabolic disease"" supported by the sentence: ""Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.""?",False, +16995162,Melatonin prevents metabolic syndrome X,4193,Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.,"Is the triple ""Melatonin prevents metabolic syndrome X"" supported by the sentence: ""Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.""?",False, +16549748,Melatonin prevents burn,4194,Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.,"Is the triple ""Melatonin prevents burn"" supported by the sentence: ""Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.""?",False, +16245777,Melatonin prevents schizophrenia,4195,"The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.","Is the triple ""Melatonin prevents schizophrenia"" supported by the sentence: ""The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.""?",False, +16232642,Melatonin prevents Marchiafava-Bignami disease,4196,"This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.","Is the triple ""Melatonin prevents Marchiafava-Bignami disease"" supported by the sentence: ""This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.""?",False, +15150085,Melatonin prevents depressive disorder,4197,"It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.","Is the triple ""Melatonin prevents depressive disorder"" supported by the sentence: ""It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.""?",False, +14373042,Melatonin prevents Parkinson disease,4198,"We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.","Is the triple ""Melatonin prevents Parkinson disease"" supported by the sentence: ""We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.""?",False, +11616466,Melatonin prevents autism spectrum disorder,4199,CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.,"Is the triple ""Melatonin prevents autism spectrum disorder"" supported by the sentence: ""CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.""?",False, +11366467,Melatonin prevents migraine disorder,4200,"Melatonin, 3 mg, is effective for migraine prevention.","Is the triple ""Melatonin prevents migraine disorder"" supported by the sentence: ""Melatonin, 3 mg, is effective for migraine prevention.""?",False, +11108260,Melatonin prevents hypertensive disorder,4201,We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.,"Is the triple ""Melatonin prevents hypertensive disorder"" supported by the sentence: ""We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.""?",False, +11061121,Melatonin prevents insomnia,4202,Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.,"Is the triple ""Melatonin prevents insomnia"" supported by the sentence: ""Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.""?",False, +10234923,Melatonin prevents breast neoplasm,4203,Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.,"Is the triple ""Melatonin prevents breast neoplasm"" supported by the sentence: ""Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.""?",False, +10127047,Melatonin prevents myocardial infarction,4204,Protective effect of melatonin on myocardial infarction.,"Is the triple ""Melatonin prevents myocardial infarction"" supported by the sentence: ""Protective effect of melatonin on myocardial infarction.""?",False, +9561452,Melatonin prevents diabetes mellitus,4205,Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.,"Is the triple ""Melatonin prevents diabetes mellitus"" supported by the sentence: ""Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.""?",False, +9346845,Melatonin prevents delirium,4206,Two cases are presented where melatonin was used to treat and prevent postoperative delirium.,"Is the triple ""Melatonin prevents delirium"" supported by the sentence: ""Two cases are presented where melatonin was used to treat and prevent postoperative delirium.""?",False, +9336280,Melatonin prevents brain ischemia,4207,"Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.","Is the triple ""Melatonin prevents brain ischemia"" supported by the sentence: ""Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.""?",False, +8678642,Melatonin prevents epilepsy,4208,"The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.","Is the triple ""Melatonin prevents epilepsy"" supported by the sentence: ""The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.""?",False, +8166782,Melatonin prevents ischemia reperfusion injury,4209,"In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.","Is the triple ""Melatonin prevents ischemia reperfusion injury"" supported by the sentence: ""In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.""?",False, +7622774,Melatonin prevents injury,4210,CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.,"Is the triple ""Melatonin prevents injury"" supported by the sentence: ""CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.""?",False, +7545974,Melatonin prevents neoplasm,4211,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin prevents neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, +19276524,Melatonin exacerbates diabetes mellitus,4212,"However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.","Is the triple ""Melatonin exacerbates diabetes mellitus"" supported by the sentence: ""However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.""?",False, +7980097,Melatonin exacerbates brain ischemia,4213,"Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.","Is the triple ""Melatonin exacerbates brain ischemia"" supported by the sentence: ""Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.""?",False, +27283551,Melatonin predisposes hypertensive disorder,4214,"Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.","Is the triple ""Melatonin predisposes hypertensive disorder"" supported by the sentence: ""Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.""?",False, +23266236,Melatonin predisposes epilepsy,4215,"CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.","Is the triple ""Melatonin predisposes epilepsy"" supported by the sentence: ""CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.""?",False, +21026194,Melatonin predisposes migraine disorder,4216,"CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.","Is the triple ""Melatonin predisposes migraine disorder"" supported by the sentence: ""CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.""?",False, +20835242,Melatonin predisposes metabolic syndrome X,4217,"Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.","Is the triple ""Melatonin predisposes metabolic syndrome X"" supported by the sentence: ""Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.""?",False, +20419573,Melatonin predisposes major depressive disorder,4218,Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.,"Is the triple ""Melatonin predisposes major depressive disorder"" supported by the sentence: ""Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.""?",False, +19382519,Melatonin predisposes periodontal disorder,4219,"With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.","Is the triple ""Melatonin predisposes periodontal disorder"" supported by the sentence: ""With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.""?",False, +18749948,Melatonin predisposes autism spectrum disorder,4220,"This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.","Is the triple ""Melatonin predisposes autism spectrum disorder"" supported by the sentence: ""This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.""?",False, +18605458,Melatonin predisposes Neonatal sepsis,4221,OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.,"Is the triple ""Melatonin predisposes Neonatal sepsis"" supported by the sentence: ""OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.""?",False, +18359560,Melatonin predisposes depressive disorder,4222,Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).,"Is the triple ""Melatonin predisposes depressive disorder"" supported by the sentence: ""Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).""?",False, +16852096,Melatonin predisposes diabetes mellitus,4223,Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.,"Is the triple ""Melatonin predisposes diabetes mellitus"" supported by the sentence: ""Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.""?",False, +15094135,Melatonin predisposes injury,4224,"The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.","Is the triple ""Melatonin predisposes injury"" supported by the sentence: ""The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.""?",False, +14875892,Melatonin predisposes pervasive developmental disorder,4225,A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.,"Is the triple ""Melatonin predisposes pervasive developmental disorder"" supported by the sentence: ""A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.""?",False, +11794031,Melatonin predisposes neoplasm,4226,"Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.","Is the triple ""Melatonin predisposes neoplasm"" supported by the sentence: ""Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.""?",False, +11643546,Melatonin predisposes dementia,4227,Melatonin relieves the neural oxidative burden that contributes to dementias.,"Is the triple ""Melatonin predisposes dementia"" supported by the sentence: ""Melatonin relieves the neural oxidative burden that contributes to dementias.""?",False, +10915746,Melatonin predisposes sleep-wake disorder,4228,"CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.","Is the triple ""Melatonin predisposes sleep-wake disorder"" supported by the sentence: ""CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.""?",False, +10114913,Melatonin predisposes myocardial infarction,4229,These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.,"Is the triple ""Melatonin predisposes myocardial infarction"" supported by the sentence: ""These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.""?",False, +12950718,RETEPLASE related to thrombotic disease,4230,Spotlight on reteplase in thrombotic occlusive disorders.,"Is the triple ""RETEPLASE related to thrombotic disease"" supported by the sentence: ""Spotlight on reteplase in thrombotic occlusive disorders.""?",False, +7082056,RETEPLASE related to stroke disorder,4231,"Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.","Is the triple ""RETEPLASE related to stroke disorder"" supported by the sentence: ""Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.""?",False, +12026281,UROKINASE related to stroke disorder,4232,Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.,"Is the triple ""UROKINASE related to stroke disorder"" supported by the sentence: ""Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.""?",False, +11808316,UROKINASE related to empyema,4233,"Intrapleural urokinase is an effective treatment, including in empyemas without loculation.","Is the triple ""UROKINASE related to empyema"" supported by the sentence: ""Intrapleural urokinase is an effective treatment, including in empyemas without loculation.""?",False, +9909017,UROKINASE related to pleural empyema,4234,Use of urokinase in childhood pleural empyema.,"Is the triple ""UROKINASE related to pleural empyema"" supported by the sentence: ""Use of urokinase in childhood pleural empyema.""?",False, +9695495,UROKINASE related to thrombotic disease,4235,Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.,"Is the triple ""UROKINASE related to thrombotic disease"" supported by the sentence: ""Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.""?",False, +7757067,UROKINASE related to pulmonary embolism,4236,CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.,"Is the triple ""UROKINASE related to pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.""?",False, +20949144,UROKINASE causes thrombotic disease,4237,"After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.","Is the triple ""UROKINASE causes thrombotic disease"" supported by the sentence: ""After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.""?",False, +7392657,UROKINASE causes pulmonary embolism,4238,"Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.","Is the triple ""UROKINASE causes pulmonary embolism"" supported by the sentence: ""Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.""?",False, +26135964,UROKINASE affects pulmonary embolism,4239,A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.,"Is the triple ""UROKINASE affects pulmonary embolism"" supported by the sentence: ""A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.""?",False, +25781305,UROKINASE affects thrombotic disease,4240,"Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.","Is the triple ""UROKINASE affects thrombotic disease"" supported by the sentence: ""Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.""?",False, +26885635,UROKINASE disrupts thrombotic disease,4241,"In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.","Is the triple ""UROKINASE disrupts thrombotic disease"" supported by the sentence: ""In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.""?",False, +11607211,UROKINASE prevents thrombotic disease,4242,"To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.","Is the triple ""UROKINASE prevents thrombotic disease"" supported by the sentence: ""To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.""?",False, +8505599,UROKINASE prevents pulmonary embolism,4243,"CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.","Is the triple ""UROKINASE prevents pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.""?",False, +26334889,UROKINASE predisposes pulmonary embolism,4244,"Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.","Is the triple ""UROKINASE predisposes pulmonary embolism"" supported by the sentence: ""Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.""?",False, +13797160,UROKINASE predisposes thrombotic disease,4245,"Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.","Is the triple ""UROKINASE predisposes thrombotic disease"" supported by the sentence: ""Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.""?",False, +13590349,Buspirone causes depressive disorder,4246,"Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.","Is the triple ""Buspirone causes depressive disorder"" supported by the sentence: ""Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.""?",False, +7712722,Buspirone affects depressive disorder,4247,"The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.","Is the triple ""Buspirone affects depressive disorder"" supported by the sentence: ""The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.""?",False, +7425584,Buspirone affects physiological sexual disorder,4248,It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.,"Is the triple ""Buspirone affects physiological sexual disorder"" supported by the sentence: ""It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.""?",False, +19950288,Buspirone disrupts schizophrenia,4249,Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.,"Is the triple ""Buspirone disrupts schizophrenia"" supported by the sentence: ""Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.""?",False, +10992881,Buspirone disrupts anxiety,4250,"CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.","Is the triple ""Buspirone disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.""?",False, +19904227,Iodine related to thyroid tumor,4251,Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.,"Is the triple ""Iodine related to thyroid tumor"" supported by the sentence: ""Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.""?",False, +10048388,Iodine related to breast neoplasm,4252,"Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.","Is the triple ""Iodine related to breast neoplasm"" supported by the sentence: ""Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.""?",False, +10651106,Iodine causes thyroid tumor,4253,Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.,"Is the triple ""Iodine causes thyroid tumor"" supported by the sentence: ""Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.""?",False, +10745802,Iodine affects thyroid tumor,4254,Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.,"Is the triple ""Iodine affects thyroid tumor"" supported by the sentence: ""Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.""?",False, +24773674,Iodine prevents thyroid tumor,4255,These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.,"Is the triple ""Iodine prevents thyroid tumor"" supported by the sentence: ""These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.""?",False, +27167996,Iodine predisposes thyroid tumor,4256,Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.,"Is the triple ""Iodine predisposes thyroid tumor"" supported by the sentence: ""Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.""?",False, +7362584,Acetaminophen subclass of Acetaminophen sulfate,4257,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen sulfate"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, +7362582,Acetaminophen subclass of Acetaminophen glucuronide,4258,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen glucuronide"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, +26133523,Acetaminophen related to neoplasm,4259,"None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.","Is the triple ""Acetaminophen related to neoplasm"" supported by the sentence: ""None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.""?",False, +25084939,Acetaminophen related to Acetimidoquinone,4260,"Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.","Is the triple ""Acetaminophen related to Acetimidoquinone"" supported by the sentence: ""Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.""?",False, +24055705,Acetaminophen related to osteoarthritis,4261,"As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.","Is the triple ""Acetaminophen related to osteoarthritis"" supported by the sentence: ""As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.""?",False, +20371329,Acetaminophen related to digestive system disorder,4262,Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.,"Is the triple ""Acetaminophen related to digestive system disorder"" supported by the sentence: ""Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.""?",False, +19637295,Acetaminophen related to Renal Colic,4263,"METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.","Is the triple ""Acetaminophen related to Renal Colic"" supported by the sentence: ""METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.""?",False, +16009572,Acetaminophen related to rheumatoid arthritis,4264,"The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).","Is the triple ""Acetaminophen related to rheumatoid arthritis"" supported by the sentence: ""The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).""?",False, +12233599,Acetaminophen related to Acetaminophen glucuronide,4265,The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.,"Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.""?",False, +12541409,Acetaminophen related to Acetaminophen glucuronide,4266,"The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).","Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).""?",False, +15777318,Acetaminophen coexists with Acetimidoquinone,4267,"In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.","Is the triple ""Acetaminophen coexists with Acetimidoquinone"" supported by the sentence: ""In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.""?",False, +18513016,Acetaminophen derives from Acetimidoquinone,4268,"Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.","Is the triple ""Acetaminophen derives from Acetimidoquinone"" supported by the sentence: ""Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.""?",False, +16596646,Acetaminophen derives from Acetaminophen glucuronide,4269,Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.,"Is the triple ""Acetaminophen derives from Acetaminophen glucuronide"" supported by the sentence: ""Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.""?",False, +7891577,Acetaminophen physically interacts with Acetimidoquinone,4270,"Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.""?",False, +11100770,Acetaminophen physically interacts with Acetimidoquinone,4271,"All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).""?",False, +8441876,Acetaminophen physically interacts with Acetaminophen glucuronide,4272,"Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.","Is the triple ""Acetaminophen physically interacts with Acetaminophen glucuronide"" supported by the sentence: ""Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.""?",False, +25685005,Acetaminophen causes neoplasm,4273,No pathologic or statistical evidence of induction of tumors by AAP was found.,"Is the triple ""Acetaminophen causes neoplasm"" supported by the sentence: ""No pathologic or statistical evidence of induction of tumors by AAP was found.""?",False, +24327037,Acetaminophen causes anxiety,4274,"In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.","Is the triple ""Acetaminophen causes anxiety"" supported by the sentence: ""In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.""?",False, +23482103,Acetaminophen causes nervous system disorder,4275,"Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.","Is the triple ""Acetaminophen causes nervous system disorder"" supported by the sentence: ""Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.""?",False, +21920646,Acetaminophen causes type 1 diabetes mellitus,4276,"A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.","Is the triple ""Acetaminophen causes type 1 diabetes mellitus"" supported by the sentence: ""A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.""?",False, +21160030,Acetaminophen causes Postoperative Nausea and Vomiting,4277,Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.,"Is the triple ""Acetaminophen causes Postoperative Nausea and Vomiting"" supported by the sentence: ""Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.""?",False, +19409287,Acetaminophen causes myopia,4278,ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.,"Is the triple ""Acetaminophen causes myopia"" supported by the sentence: ""ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.""?",False, +17485084,Acetaminophen causes obesity disorder,4279,Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.,"Is the triple ""Acetaminophen causes obesity disorder"" supported by the sentence: ""Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.""?",False, +17093716,Acetaminophen causes kidney disorder,4280,"PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.","Is the triple ""Acetaminophen causes kidney disorder"" supported by the sentence: ""PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.""?",False, +16903597,Acetaminophen causes hypertensive disorder,4281,"Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.","Is the triple ""Acetaminophen causes hypertensive disorder"" supported by the sentence: ""Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.""?",False, +16867510,Acetaminophen causes delirium,4282,Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.,"Is the triple ""Acetaminophen causes delirium"" supported by the sentence: ""Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.""?",False, +16756158,Acetaminophen causes osteoarthritis,4283,"Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.","Is the triple ""Acetaminophen causes osteoarthritis"" supported by the sentence: ""Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.""?",False, +16155885,Acetaminophen causes Hemorrhage,4284,"CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.","Is the triple ""Acetaminophen causes Hemorrhage"" supported by the sentence: ""CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.""?",False, +15922778,Acetaminophen causes Pruritus,4285,"Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.","Is the triple ""Acetaminophen causes Pruritus"" supported by the sentence: ""Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.""?",False, +14972793,Acetaminophen causes brain injury,4286,High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.,"Is the triple ""Acetaminophen causes brain injury"" supported by the sentence: ""High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.""?",False, +12302511,Acetaminophen causes Headache,4287,"Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.","Is the triple ""Acetaminophen causes Headache"" supported by the sentence: ""Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.""?",False, +9507087,Acetaminophen causes Vomiting,4288,A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.,"Is the triple ""Acetaminophen causes Vomiting"" supported by the sentence: ""A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.""?",False, +8697178,Acetaminophen causes Pain,4289,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Pain"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, +8697177,Acetaminophen causes Fever,4290,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Fever"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, +7330301,Acetaminophen causes injury,4291,"Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.","Is the triple ""Acetaminophen causes injury"" supported by the sentence: ""Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.""?",False, +24793249,Acetaminophen affects hypertensive disorder,4292,Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.,"Is the triple ""Acetaminophen affects hypertensive disorder"" supported by the sentence: ""Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.""?",False, +23912807,Acetaminophen affects Vomiting,4293,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, +23912806,Acetaminophen affects Nausea,4294,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, +23442508,Acetaminophen affects pharyngitis,4295,"The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.","Is the triple ""Acetaminophen affects pharyngitis"" supported by the sentence: ""The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.""?",False, +23226380,Acetaminophen affects anxiety,4296,"Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.","Is the triple ""Acetaminophen affects anxiety"" supported by the sentence: ""Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.""?",False, +22849168,Acetaminophen affects neoplasm,4297,The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.,"Is the triple ""Acetaminophen affects neoplasm"" supported by the sentence: ""The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.""?",False, +22389406,Acetaminophen affects Low back pain,4298,"This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.","Is the triple ""Acetaminophen affects Low back pain"" supported by the sentence: ""This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.""?",False, +22267005,Acetaminophen affects Acute Pain,4299,"Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.","Is the triple ""Acetaminophen affects Acute Pain"" supported by the sentence: ""Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.""?",False, +21609859,Acetaminophen affects migraine disorder,4300,The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.,"Is the triple ""Acetaminophen affects migraine disorder"" supported by the sentence: ""The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.""?",False, +21375424,Acetaminophen affects preeclampsia,4301,"Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.","Is the triple ""Acetaminophen affects preeclampsia"" supported by the sentence: ""Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.""?",False, +21166764,Acetaminophen affects Parkinson disease,4302,"Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.","Is the triple ""Acetaminophen affects Parkinson disease"" supported by the sentence: ""Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.""?",False, +20477729,Acetaminophen affects Hemorrhage,4303,"RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).","Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).""?",False, +20447454,Acetaminophen affects rheumatoid arthritis,4304,"Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.","Is the triple ""Acetaminophen affects rheumatoid arthritis"" supported by the sentence: ""Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.""?",False, +19937801,Acetaminophen affects Pain,4305,Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.,"Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.""?",False, +19285056,Acetaminophen affects Renal Colic,4306,"BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.","Is the triple ""Acetaminophen affects Renal Colic"" supported by the sentence: ""BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.""?",False, +18899993,Acetaminophen affects Abdominal pain,4307,Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).,"Is the triple ""Acetaminophen affects Abdominal pain"" supported by the sentence: ""Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).""?",False, +18709599,Acetaminophen affects Acetimidoquinone,4308,The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.,"Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.""?",False, +18394888,Acetaminophen affects Headache,4309,"She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.","Is the triple ""Acetaminophen affects Headache"" supported by the sentence: ""She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.""?",False, +18298999,Acetaminophen affects patent ductus arteriosus,4310,Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.,"Is the triple ""Acetaminophen affects patent ductus arteriosus"" supported by the sentence: ""Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.""?",False, +16707575,Acetaminophen affects obesity disorder,4311,"The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.","Is the triple ""Acetaminophen affects obesity disorder"" supported by the sentence: ""The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.""?",False, +16662805,Acetaminophen affects Vomiting,4312,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, +16662804,Acetaminophen affects Nausea,4313,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, +15922777,Acetaminophen affects Pruritus,4314,Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.,"Is the triple ""Acetaminophen affects Pruritus"" supported by the sentence: ""Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.""?",False, +15909356,Acetaminophen affects Postoperative Nausea and Vomiting,4315,OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.,"Is the triple ""Acetaminophen affects Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.""?",False, +12673406,Acetaminophen affects bone fracture,4316,"For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).","Is the triple ""Acetaminophen affects bone fracture"" supported by the sentence: ""For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).""?",False, +12488756,Acetaminophen affects Acetaminophen glucuronide,4317,"The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.""?",False, +11625632,Acetaminophen affects Chronic pain,4318,The role of paracetamol in chronic pain: an evidence-based approach.,"Is the triple ""Acetaminophen affects Chronic pain"" supported by the sentence: ""The role of paracetamol in chronic pain: an evidence-based approach.""?",False, +11439823,Acetaminophen affects type 1 diabetes mellitus,4319,"The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.","Is the triple ""Acetaminophen affects type 1 diabetes mellitus"" supported by the sentence: ""The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.""?",False, +11319146,Acetaminophen affects neuralgia,4320,The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.,"Is the triple ""Acetaminophen affects neuralgia"" supported by the sentence: ""The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.""?",False, +11289717,Acetaminophen affects osteoarthritis,4321,"Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.","Is the triple ""Acetaminophen affects osteoarthritis"" supported by the sentence: ""Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.""?",False, +11227783,Acetaminophen affects Fever,4322,Young age and high fever were associated with significantly higher acetaminophen levels.,"Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Young age and high fever were associated with significantly higher acetaminophen levels.""?",False, +11159989,Acetaminophen affects Hemorrhage,4323,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?",False, +10410536,Acetaminophen affects injury,4324,Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).,"Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).""?",False, +10195419,Acetaminophen affects Pain,4325,"The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.","Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.""?",False, +9259287,Acetaminophen affects Fever,4326,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, +8642669,Acetaminophen affects Hemorrhage,4327,CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.""?",False, +8097597,Acetaminophen affects injury,4328,"These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.","Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.""?",False, +25639149,Acetaminophen affects Acetaminophen glucuronide,4329,"Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.""?",False, +20782169,Acetaminophen affects Acetimidoquinone,4330,"Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.","Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.""?",False, +25481457,Acetaminophen disrupts patent ductus arteriosus,4331,"Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.","Is the triple ""Acetaminophen disrupts patent ductus arteriosus"" supported by the sentence: ""Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.""?",False, +25355292,Acetaminophen disrupts delirium,4332,"Individually, acetaminophen was associated with reduced delirium.","Is the triple ""Acetaminophen disrupts delirium"" supported by the sentence: ""Individually, acetaminophen was associated with reduced delirium.""?",False, +19614622,Acetaminophen disrupts Headache,4333,The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.,"Is the triple ""Acetaminophen disrupts Headache"" supported by the sentence: ""The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.""?",False, +16273113,Acetaminophen disrupts Fever,4334,"Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.","Is the triple ""Acetaminophen disrupts Fever"" supported by the sentence: ""Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.""?",False, +12102031,Acetaminophen disrupts Pain,4335,Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.,"Is the triple ""Acetaminophen disrupts Pain"" supported by the sentence: ""Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.""?",False, +7794905,Acetaminophen disrupts influenza,4336,"Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.","Is the triple ""Acetaminophen disrupts influenza"" supported by the sentence: ""Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.""?",False, +7640332,Acetaminophen disrupts injury,4337,"RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).","Is the triple ""Acetaminophen disrupts injury"" supported by the sentence: ""RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).""?",False, +26559635,Acetaminophen prevents malaria,4338,Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.,"Is the triple ""Acetaminophen prevents malaria"" supported by the sentence: ""Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.""?",False, +22159381,Acetaminophen prevents Hemorrhage,4339,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.","Is the triple ""Acetaminophen prevents Hemorrhage"" supported by the sentence: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?",False, +22123298,Acetaminophen prevents Fever,4340,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,"Is the triple ""Acetaminophen prevents Fever"" supported by the sentence: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?",False, +20154151,Acetaminophen prevents neuralgia,4341,"Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.","Is the triple ""Acetaminophen prevents neuralgia"" supported by the sentence: ""Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.""?",False, +20107193,Acetaminophen prevents delirium,4342,The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.,"Is the triple ""Acetaminophen prevents delirium"" supported by the sentence: ""The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.""?",False, +19168014,Acetaminophen prevents obesity disorder,4343,AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.,"Is the triple ""Acetaminophen prevents obesity disorder"" supported by the sentence: ""AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.""?",False, +19006111,Acetaminophen prevents patent ductus arteriosus,4344,Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.,"Is the triple ""Acetaminophen prevents patent ductus arteriosus"" supported by the sentence: ""Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.""?",False, +18131378,Acetaminophen prevents Low back pain,4345,CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.,"Is the triple ""Acetaminophen prevents Low back pain"" supported by the sentence: ""CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.""?",False, +18033682,Acetaminophen prevents Vomiting,4346,"Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).","Is the triple ""Acetaminophen prevents Vomiting"" supported by the sentence: ""Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).""?",False, +16975983,Acetaminophen prevents neoplasm,4347,Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.,"Is the triple ""Acetaminophen prevents neoplasm"" supported by the sentence: ""Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.""?",False, +16828191,Acetaminophen prevents rheumatoid arthritis,4348,"RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.","Is the triple ""Acetaminophen prevents rheumatoid arthritis"" supported by the sentence: ""RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.""?",False, +16784082,Acetaminophen prevents injury,4349,Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.,"Is the triple ""Acetaminophen prevents injury"" supported by the sentence: ""Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.""?",False, +16782348,Acetaminophen prevents Nausea,4350,"When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).","Is the triple ""Acetaminophen prevents Nausea"" supported by the sentence: ""When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).""?",False, +15909357,Acetaminophen prevents Postoperative Nausea and Vomiting,4351,CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.,"Is the triple ""Acetaminophen prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.""?",False, +15525446,Acetaminophen prevents Acute Pain,4352,Review: acetaminophen reduces acute migraine pain in adults.,"Is the triple ""Acetaminophen prevents Acute Pain"" supported by the sentence: ""Review: acetaminophen reduces acute migraine pain in adults.""?",False, +15467414,Acetaminophen prevents influenza,4353,METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.,"Is the triple ""Acetaminophen prevents influenza"" supported by the sentence: ""METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.""?",False, +14660734,Acetaminophen prevents cardiac rhythm disease,4354,"This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.","Is the triple ""Acetaminophen prevents cardiac rhythm disease"" supported by the sentence: ""This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.""?",False, +14372292,Acetaminophen prevents Headache,4355,"Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.","Is the triple ""Acetaminophen prevents Headache"" supported by the sentence: ""Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.""?",False, +13804263,Acetaminophen prevents type 2 diabetes mellitus,4356,"We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.","Is the triple ""Acetaminophen prevents type 2 diabetes mellitus"" supported by the sentence: ""We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.""?",False, +8695490,Acetaminophen prevents Pain,4357,"Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.","Is the triple ""Acetaminophen prevents Pain"" supported by the sentence: ""Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.""?",False, +25567880,Acetaminophen predisposes Sepsis,4358,Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?,"Is the triple ""Acetaminophen predisposes Sepsis"" supported by the sentence: ""Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?""?",False, +24917204,Acetaminophen predisposes type 2 diabetes mellitus,4359,"CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.","Is the triple ""Acetaminophen predisposes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.""?",False, +22230555,Acetaminophen predisposes delirium,4360,"Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.","Is the triple ""Acetaminophen predisposes delirium"" supported by the sentence: ""Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.""?",False, +21723139,Acetaminophen predisposes Hemorrhage,4361,"Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.","Is the triple ""Acetaminophen predisposes Hemorrhage"" supported by the sentence: ""Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.""?",False, +20594449,Acetaminophen predisposes neoplasm,4362,"The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Acetaminophen predisposes neoplasm"" supported by the sentence: ""The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).""?",False, +19914508,Acetaminophen predisposes Pain,4363,"Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.","Is the triple ""Acetaminophen predisposes Pain"" supported by the sentence: ""Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.""?",False, +16209480,Acetaminophen predisposes kidney disorder,4364,Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).,"Is the triple ""Acetaminophen predisposes kidney disorder"" supported by the sentence: ""Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).""?",False, +13597848,Acetaminophen predisposes injury,4365,"After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.","Is the triple ""Acetaminophen predisposes injury"" supported by the sentence: ""After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.""?",False, +13536066,Acetaminophen predisposes non-small cell lung carcinoma,4366,"METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.","Is the triple ""Acetaminophen predisposes non-small cell lung carcinoma"" supported by the sentence: ""METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.""?",False, +12673403,Acetaminophen predisposes bone fracture,4367,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Acetaminophen predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, +12109634,Acetaminophen predisposes Parkinson disease,4368,"No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.","Is the triple ""Acetaminophen predisposes Parkinson disease"" supported by the sentence: ""No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.""?",False, +11873681,Acetaminophen predisposes non-Hodgkin lymphoma,4369,"Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.","Is the triple ""Acetaminophen predisposes non-Hodgkin lymphoma"" supported by the sentence: ""Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.""?",False, +9834508,Acetaminophen predisposes hypertensive disorder,4370,"CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.","Is the triple ""Acetaminophen predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.""?",False, +8862839,Acetaminophen predisposes streptococcal infection,4371,Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.,"Is the triple ""Acetaminophen predisposes streptococcal infection"" supported by the sentence: ""Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.""?",False, +10289439,Chlorthalidone related to hypertensive disorder,4372,Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.,"Is the triple ""Chlorthalidone related to hypertensive disorder"" supported by the sentence: ""Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.""?",False, +10185607,Chlorthalidone related to coronary artery disorder,4373,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to coronary artery disorder"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, +10185606,Chlorthalidone related to myocardial infarction,4374,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to myocardial infarction"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, +7839079,Chlorthalidone related to essential hypertension,4375,Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.,"Is the triple ""Chlorthalidone related to essential hypertension"" supported by the sentence: ""Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.""?",False, +21616164,Chlorthalidone affects myocardial infarction,4376,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects myocardial infarction"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, +21616163,Chlorthalidone affects coronary artery disorder,4377,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects coronary artery disorder"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, +16399514,Chlorthalidone affects essential hypertension,4378,"In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.","Is the triple ""Chlorthalidone affects essential hypertension"" supported by the sentence: ""In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.""?",False, +16281975,Chlorthalidone affects hypertensive disorder,4379,"In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.","Is the triple ""Chlorthalidone affects hypertensive disorder"" supported by the sentence: ""In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.""?",False, +11587035,Chlorthalidone affects diabetes mellitus,4380,Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.,"Is the triple ""Chlorthalidone affects diabetes mellitus"" supported by the sentence: ""Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.""?",False, +11095498,Chlorthalidone prevents myocardial infarction,4381,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents myocardial infarction"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, +11095497,Chlorthalidone prevents coronary artery disorder,4382,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents coronary artery disorder"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, +8853238,Chlorthalidone prevents myocardial ischemia,4383,"CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.","Is the triple ""Chlorthalidone prevents myocardial ischemia"" supported by the sentence: ""CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.""?",False, +8036244,Chlorthalidone prevents hypertensive disorder,4384,"Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.","Is the triple ""Chlorthalidone prevents hypertensive disorder"" supported by the sentence: ""Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.""?",False, +11078982,Chlorthalidone predisposes coronary artery disorder,4385,"The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.","Is the triple ""Chlorthalidone predisposes coronary artery disorder"" supported by the sentence: ""The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.""?",False, +19123757,Propacetamol causes Pain,4386,"In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.","Is the triple ""Propacetamol causes Pain"" supported by the sentence: ""In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.""?",False, +11402898,Propacetamol prevents Pain,4387,BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.,"Is the triple ""Propacetamol prevents Pain"" supported by the sentence: ""BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.""?",False, +25540651,Isopropyl Alcohol affects Nausea,4388,"CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.","Is the triple ""Isopropyl Alcohol affects Nausea"" supported by the sentence: ""CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.""?",False, +18311094,Isopropyl Alcohol affects infectious disease,4389,CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.,"Is the triple ""Isopropyl Alcohol affects infectious disease"" supported by the sentence: ""CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.""?",False, +10697335,Isopropyl Alcohol affects burn,4390,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Isopropyl Alcohol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, +9427033,Isopropyl Alcohol prevents infectious disease,4391,"The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.","Is the triple ""Isopropyl Alcohol prevents infectious disease"" supported by the sentence: ""The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.""?",False, +21320482,Ethanol related to substance-related disorder,4392,"METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).","Is the triple ""Ethanol related to substance-related disorder"" supported by the sentence: ""METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).""?",False, +15908919,Ethanol related to hypertensive disorder,4393,"Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.","Is the triple ""Ethanol related to hypertensive disorder"" supported by the sentence: ""Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.""?",False, +14538852,Ethanol related to atrial fibrillation,4394,CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.,"Is the triple ""Ethanol related to atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.""?",False, +13852361,Ethanol related to obesity disorder,4395,"Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.","Is the triple ""Ethanol related to obesity disorder"" supported by the sentence: ""Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.""?",False, +27116018,Ethanol causes neutropenia,4396,"EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.","Is the triple ""Ethanol causes neutropenia"" supported by the sentence: ""EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.""?",False, +26520376,Ethanol causes essential hypertension,4397,"Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.","Is the triple ""Ethanol causes essential hypertension"" supported by the sentence: ""Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.""?",False, +17336935,Ethanol causes Tremor,4398,"We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.","Is the triple ""Ethanol causes Tremor"" supported by the sentence: ""We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.""?",False, +15073107,Ethanol causes alcohol-related disorders,4399,"CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.","Is the triple ""Ethanol causes alcohol-related disorders"" supported by the sentence: ""CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.""?",False, +14779551,Ethanol causes burn,4400,CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.,"Is the triple ""Ethanol causes burn"" supported by the sentence: ""CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.""?",False, +12227250,Ethanol causes bacterial infectious disease with sepsis,4401,Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.,"Is the triple ""Ethanol causes bacterial infectious disease with sepsis"" supported by the sentence: ""Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.""?",False, +11665347,Ethanol causes erectile dysfunction,4402,"Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.","Is the triple ""Ethanol causes erectile dysfunction"" supported by the sentence: ""Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.""?",False, +11096896,Ethanol causes type 2 diabetes mellitus,4403,"Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.","Is the triple ""Ethanol causes type 2 diabetes mellitus"" supported by the sentence: ""Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.""?",False, +10962858,Ethanol causes atrial fibrillation,4404,This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.,"Is the triple ""Ethanol causes atrial fibrillation"" supported by the sentence: ""This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.""?",False, +9159992,Ethanol causes obesity disorder,4405,"In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.","Is the triple ""Ethanol causes obesity disorder"" supported by the sentence: ""In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.""?",False, +8743651,Ethanol causes alcohol abuse,4406,"Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.","Is the triple ""Ethanol causes alcohol abuse"" supported by the sentence: ""Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.""?",False, +8636726,Ethanol causes major depressive disorder,4407,"For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.","Is the triple ""Ethanol causes major depressive disorder"" supported by the sentence: ""For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.""?",False, +8268450,Ethanol causes atopic eczema,4408,Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.,"Is the triple ""Ethanol causes atopic eczema"" supported by the sentence: ""Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.""?",False, +7771647,Ethanol causes hypertensive disorder,4409,High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.,"Is the triple ""Ethanol causes hypertensive disorder"" supported by the sentence: ""High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.""?",False, +7460012,Ethanol causes cirrhosis of liver,4410,[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].,"Is the triple ""Ethanol causes cirrhosis of liver"" supported by the sentence: ""[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].""?",False, +27580478,Ethanol affects cirrhosis of liver,4411,CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.,"Is the triple ""Ethanol affects cirrhosis of liver"" supported by the sentence: ""CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.""?",False, +27514790,Ethanol affects Thyroid nodule,4412,"In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.","Is the triple ""Ethanol affects Thyroid nodule"" supported by the sentence: ""In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.""?",False, +26762447,Ethanol affects neutropenia,4413,"To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).","Is the triple ""Ethanol affects neutropenia"" supported by the sentence: ""To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).""?",False, +23912654,Ethanol affects atrial fibrillation,4414,"Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.""?",False, +23763968,Ethanol affects substance-related disorder,4415,"CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.","Is the triple ""Ethanol affects substance-related disorder"" supported by the sentence: ""CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.""?",False, +19533165,Ethanol affects hypertensive disorder,4416,"As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.","Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.""?",False, +19155713,Ethanol affects cannabis dependence,4417,"Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.","Is the triple ""Ethanol affects cannabis dependence"" supported by the sentence: ""Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.""?",False, +16819917,Ethanol affects Chronic pain,4418,"INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.""?",False, +15671844,Ethanol affects obesity disorder,4419,"The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.""?",False, +14737169,Ethanol affects Chronic pain,4420,"Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.""?",False, +14527564,Ethanol affects benign prostatic hyperplasia,4421,Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.,"Is the triple ""Ethanol affects benign prostatic hyperplasia"" supported by the sentence: ""Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.""?",False, +13226372,Ethanol affects atrial fibrillation,4422,"BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.""?",False, +12698965,Ethanol affects major depressive disorder,4423,"An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.""?",False, +12166837,Ethanol affects type 2 diabetes mellitus,4424,Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.""?",False, +10697334,Ethanol affects burn,4425,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, +9822489,Ethanol affects Tremor,4426,"Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.""?",False, +9174558,Ethanol affects Tremor,4427,"The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.""?",False, +9116052,Ethanol affects major depressive disorder,4428,"RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.""?",False, +8931619,Ethanol affects hypertensive disorder,4429,The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.,"Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.""?",False, +8730041,Ethanol affects burn,4430,"Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.""?",False, +8616967,Ethanol affects type 2 diabetes mellitus,4431,CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.""?",False, +8569555,Ethanol affects alcohol abuse,4432,"This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.""?",False, +8363507,Ethanol affects obesity disorder,4433,"Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.""?",False, +7210977,Ethanol affects alcohol abuse,4434,"CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.""?",False, +25366419,Ethanol disrupts ventricular tachycardia,4435,"However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.","Is the triple ""Ethanol disrupts ventricular tachycardia"" supported by the sentence: ""However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.""?",False, +24747388,Ethanol disrupts obesity disorder,4436,"In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.","Is the triple ""Ethanol disrupts obesity disorder"" supported by the sentence: ""In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.""?",False, +22793590,Ethanol disrupts Infection,4437,"In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.","Is the triple ""Ethanol disrupts Infection"" supported by the sentence: ""In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.""?",False, +20664067,Ethanol disrupts Chronic pain,4438,"Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).","Is the triple ""Ethanol disrupts Chronic pain"" supported by the sentence: ""Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).""?",False, +19084276,Ethanol disrupts hypertensive disorder,4439,"Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.","Is the triple ""Ethanol disrupts hypertensive disorder"" supported by the sentence: ""Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.""?",False, +15586620,Ethanol disrupts Tremor,4440,Temporary suppression of the tremor by alcohol is seen in about one-third of cases.,"Is the triple ""Ethanol disrupts Tremor"" supported by the sentence: ""Temporary suppression of the tremor by alcohol is seen in about one-third of cases.""?",False, +15580442,Ethanol disrupts atrial fibrillation,4441,"In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).","Is the triple ""Ethanol disrupts atrial fibrillation"" supported by the sentence: ""In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).""?",False, +12535146,Ethanol disrupts type 2 diabetes mellitus,4442,Alcohol from wine was associated with reduced risk of Type 2 diabetes.,"Is the triple ""Ethanol disrupts type 2 diabetes mellitus"" supported by the sentence: ""Alcohol from wine was associated with reduced risk of Type 2 diabetes.""?",False, +9920913,Ethanol disrupts constipation disorder,4443,"Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).","Is the triple ""Ethanol disrupts constipation disorder"" supported by the sentence: ""Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).""?",False, +27717904,Ethanol prevents cirrhosis of liver,4444,HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.,"Is the triple ""Ethanol prevents cirrhosis of liver"" supported by the sentence: ""HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.""?",False, +22976273,Ethanol prevents Infection,4445,Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.,"Is the triple ""Ethanol prevents Infection"" supported by the sentence: ""Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.""?",False, +21338360,Ethanol prevents atrial fibrillation,4446,Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.,"Is the triple ""Ethanol prevents atrial fibrillation"" supported by the sentence: ""Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.""?",False, +20664068,Ethanol prevents Chronic pain,4447,An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.,"Is the triple ""Ethanol prevents Chronic pain"" supported by the sentence: ""An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.""?",False, +14465260,Ethanol prevents bacterial infectious disease with sepsis,4448,Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.,"Is the triple ""Ethanol prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.""?",False, +13158318,Ethanol prevents erectile dysfunction,4449,More research is needed to confirm whether alcohol is protective or is unrelated to ED development.,"Is the triple ""Ethanol prevents erectile dysfunction"" supported by the sentence: ""More research is needed to confirm whether alcohol is protective or is unrelated to ED development.""?",False, +12078103,Ethanol prevents alcohol abuse,4450,"Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.","Is the triple ""Ethanol prevents alcohol abuse"" supported by the sentence: ""Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.""?",False, +11890775,Ethanol prevents type 2 diabetes mellitus,4451,Alcohol for the prevention of type 2 diabetes mellitus?,"Is the triple ""Ethanol prevents type 2 diabetes mellitus"" supported by the sentence: ""Alcohol for the prevention of type 2 diabetes mellitus?""?",False, +11547578,Ethanol prevents Tremor,4452,"Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.","Is the triple ""Ethanol prevents Tremor"" supported by the sentence: ""Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.""?",False, +10032139,Ethanol prevents obesity disorder,4453,"During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.","Is the triple ""Ethanol prevents obesity disorder"" supported by the sentence: ""During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.""?",False, +8207881,Ethanol prevents hypertensive disorder,4454,Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.,"Is the triple ""Ethanol prevents hypertensive disorder"" supported by the sentence: ""Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.""?",False, +26228661,Ethanol predisposes essential hypertension,4455,"Alcohol, personality and predisposition to essential hypertension.","Is the triple ""Ethanol predisposes essential hypertension"" supported by the sentence: ""Alcohol, personality and predisposition to essential hypertension.""?",False, +23006394,Ethanol predisposes constipation disorder,4456,"The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.","Is the triple ""Ethanol predisposes constipation disorder"" supported by the sentence: ""The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.""?",False, +21458894,Ethanol predisposes burn,4457,The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.,"Is the triple ""Ethanol predisposes burn"" supported by the sentence: ""The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.""?",False, +21015200,Ethanol predisposes benign prostatic hyperplasia,4458,The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.,"Is the triple ""Ethanol predisposes benign prostatic hyperplasia"" supported by the sentence: ""The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.""?",False, +20014749,Ethanol predisposes neuroblastoma,4459,"STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.","Is the triple ""Ethanol predisposes neuroblastoma"" supported by the sentence: ""STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.""?",False, +19550164,Ethanol predisposes endometriosis,4460,"Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.","Is the triple ""Ethanol predisposes endometriosis"" supported by the sentence: ""Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.""?",False, +15239058,Ethanol predisposes cannabis dependence,4461,"Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.","Is the triple ""Ethanol predisposes cannabis dependence"" supported by the sentence: ""Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.""?",False, +13742110,Ethanol predisposes cirrhosis of liver,4462,"It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.","Is the triple ""Ethanol predisposes cirrhosis of liver"" supported by the sentence: ""It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.""?",False, +13158317,Ethanol predisposes erectile dysfunction,4463,"Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.","Is the triple ""Ethanol predisposes erectile dysfunction"" supported by the sentence: ""Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.""?",False, +11801709,Ethanol predisposes type 2 diabetes mellitus,4464,No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.,"Is the triple ""Ethanol predisposes type 2 diabetes mellitus"" supported by the sentence: ""No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.""?",False, +11652545,Ethanol predisposes obesity disorder,4465,Alcohol could contribute to obesity.,"Is the triple ""Ethanol predisposes obesity disorder"" supported by the sentence: ""Alcohol could contribute to obesity.""?",False, +11461204,Ethanol predisposes atrial fibrillation,4466,"In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.","Is the triple ""Ethanol predisposes atrial fibrillation"" supported by the sentence: ""In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.""?",False, +9864711,Ethanol predisposes major depressive disorder,4467,"Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.","Is the triple ""Ethanol predisposes major depressive disorder"" supported by the sentence: ""Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.""?",False, +9226083,Ethanol predisposes alcohol abuse,4468,BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.,"Is the triple ""Ethanol predisposes alcohol abuse"" supported by the sentence: ""BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.""?",False, +8895200,Ethanol predisposes hypertensive disorder,4469,The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.,"Is the triple ""Ethanol predisposes hypertensive disorder"" supported by the sentence: ""The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.""?",False, +22402878,Sodium Hypochlorite related to Infection,4470,Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.,"Is the triple ""Sodium Hypochlorite related to Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.""?",False, +22402879,Sodium Hypochlorite prevents Infection,4471,"Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.","Is the triple ""Sodium Hypochlorite prevents Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.""?",False, +22325598,Sodium Hypochlorite prevents Pain,4472,"Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.","Is the triple ""Sodium Hypochlorite prevents Pain"" supported by the sentence: ""Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.""?",False, +23522159,Hydrogen Peroxide related to gingivitis,4473,"Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.","Is the triple ""Hydrogen Peroxide related to gingivitis"" supported by the sentence: ""Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.""?",False, +10185817,Hydrogen Peroxide related to acne,4474,STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.,"Is the triple ""Hydrogen Peroxide related to acne"" supported by the sentence: ""STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.""?",False, +9091124,Hydrogen Peroxide related to injury,4475,Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.,"Is the triple ""Hydrogen Peroxide related to injury"" supported by the sentence: ""Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.""?",False, +21979927,Hydrogen Peroxide causes seborrheic keratosis,4476,Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.,"Is the triple ""Hydrogen Peroxide causes seborrheic keratosis"" supported by the sentence: ""Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.""?",False, +7121153,Hydrogen Peroxide causes injury,4477,Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.,"Is the triple ""Hydrogen Peroxide causes injury"" supported by the sentence: ""Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.""?",False, +18988282,Hydrogen Peroxide affects severe acute respiratory syndrome,4478,"Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.","Is the triple ""Hydrogen Peroxide affects severe acute respiratory syndrome"" supported by the sentence: ""Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.""?",False, +15261236,Hydrogen Peroxide affects gingivitis,4479,"Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.","Is the triple ""Hydrogen Peroxide affects gingivitis"" supported by the sentence: ""Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.""?",False, +9489971,Hydrogen Peroxide affects injury,4480,Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.""?",False, +7188934,Hydrogen Peroxide affects injury,4481,These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.""?",False, +20490056,Hydrogen Peroxide disrupts dental caries,4482,"Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.","Is the triple ""Hydrogen Peroxide disrupts dental caries"" supported by the sentence: ""Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.""?",False, +17081431,Hydrogen Peroxide disrupts injury,4483,Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.,"Is the triple ""Hydrogen Peroxide disrupts injury"" supported by the sentence: ""Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.""?",False, +8804977,Hydrogen Peroxide disrupts gingivitis,4484,CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.,"Is the triple ""Hydrogen Peroxide disrupts gingivitis"" supported by the sentence: ""CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.""?",False, +21124110,Hydrogen Peroxide prevents acne,4485,"Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.","Is the triple ""Hydrogen Peroxide prevents acne"" supported by the sentence: ""Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.""?",False, +11091070,Hydrogen Peroxide prevents gingivitis,4486,CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.,"Is the triple ""Hydrogen Peroxide prevents gingivitis"" supported by the sentence: ""CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.""?",False, +7482647,Hydrogen Peroxide prevents injury,4487,"Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.","Is the triple ""Hydrogen Peroxide prevents injury"" supported by the sentence: ""Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.""?",False, +19925807,Hydrogen Peroxide predisposes dental caries,4488,"Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.","Is the triple ""Hydrogen Peroxide predisposes dental caries"" supported by the sentence: ""Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.""?",False, +10852631,Hydrogen Peroxide predisposes injury,4489,Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.,"Is the triple ""Hydrogen Peroxide predisposes injury"" supported by the sentence: ""Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.""?",False, +23181733,Vitamin K1 related to Hemorrhage,4490,"Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).","Is the triple ""Vitamin K1 related to Hemorrhage"" supported by the sentence: ""Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).""?",False, +20221966,Vitamin K1 related to postmenopausal osteoporosis,4491,Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.,"Is the triple ""Vitamin K1 related to postmenopausal osteoporosis"" supported by the sentence: ""Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.""?",False, +19764095,Vitamin K1 related to osteoporosis,4492,Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.,"Is the triple ""Vitamin K1 related to osteoporosis"" supported by the sentence: ""Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.""?",False, +17682094,Vitamin K1 related to atrial fibrillation,4493,We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.,"Is the triple ""Vitamin K1 related to atrial fibrillation"" supported by the sentence: ""We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.""?",False, +13777524,Vitamin K1 related to cystic fibrosis,4494,Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.,"Is the triple ""Vitamin K1 related to cystic fibrosis"" supported by the sentence: ""Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.""?",False, +11304774,Vitamin K1 affects Hemorrhage,4495,"RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.","Is the triple ""Vitamin K1 affects Hemorrhage"" supported by the sentence: ""RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.""?",False, +24408540,Vitamin K1 prevents Hemorrhage,4496,OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.,"Is the triple ""Vitamin K1 prevents Hemorrhage"" supported by the sentence: ""OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.""?",False, +13476259,Vitamin K1 prevents vitamin K deficiency hemorrhagic disease,4497,OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.,"Is the triple ""Vitamin K1 prevents vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.""?",False, +10772424,Vitamin K1 predisposes postmenopausal osteoporosis,4498,"If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.","Is the triple ""Vitamin K1 predisposes postmenopausal osteoporosis"" supported by the sentence: ""If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.""?",False, +9319754,Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease,4499,"Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.","Is the triple ""Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.""?",False, +24430542,Indapamide causes type 2 diabetes mellitus,4500,The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).,"Is the triple ""Indapamide causes type 2 diabetes mellitus"" supported by the sentence: ""The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).""?",False, +24430545,Indapamide affects type 2 diabetes mellitus,4501,"INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.","Is the triple ""Indapamide affects type 2 diabetes mellitus"" supported by the sentence: ""INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.""?",False, +10214767,Indapamide affects hypertensive disorder,4502,This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.,"Is the triple ""Indapamide affects hypertensive disorder"" supported by the sentence: ""This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.""?",False, +13327254,Indapamide prevents hypertensive disorder,4503,During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.,"Is the triple ""Indapamide prevents hypertensive disorder"" supported by the sentence: ""During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.""?",False, +18173402,Perphenazine related to schizophrenia,4504,Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.,"Is the triple ""Perphenazine related to schizophrenia"" supported by the sentence: ""Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.""?",False, +11307427,Perphenazine related to Postoperative Nausea and Vomiting,4505,"CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.","Is the triple ""Perphenazine related to Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.""?",False, +19924977,Perphenazine disrupts cocaine dependence,4506,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts cocaine dependence"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, +19924976,Perphenazine disrupts schizophrenia,4507,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts schizophrenia"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, +15171439,Perphenazine prevents Postoperative Nausea and Vomiting,4508,CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.,"Is the triple ""Perphenazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.""?",False, +27208453,Perphenazine exacerbates dementia,4509,We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.,"Is the triple ""Perphenazine exacerbates dementia"" supported by the sentence: ""We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.""?",False, +26847530,Fluphenazine affects psychotic disorder,4510,BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.,"Is the triple ""Fluphenazine affects psychotic disorder"" supported by the sentence: ""BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.""?",False, +11127872,Fluphenazine prevents psychotic disorder,4511,"Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.","Is the triple ""Fluphenazine prevents psychotic disorder"" supported by the sentence: ""Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.""?",False, +10396371,Prochlorperazine disrupts Nausea,4512,"A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.","Is the triple ""Prochlorperazine disrupts Nausea"" supported by the sentence: ""A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.""?",False, +11808182,Prochlorperazine prevents Postoperative Nausea and Vomiting,4513,"OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.","Is the triple ""Prochlorperazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.""?",False, +10634177,Prochlorperazine prevents migraine disorder,4514,Prevention of migraine in children by prochlorperazine.,"Is the triple ""Prochlorperazine prevents migraine disorder"" supported by the sentence: ""Prevention of migraine in children by prochlorperazine.""?",False, +7427448,Prochlorperazine prevents Nausea,4515,Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.,"Is the triple ""Prochlorperazine prevents Nausea"" supported by the sentence: ""Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.""?",False, +11272109,ELOSULFASE ALFA related to mucopolysaccharidosis type 4,4516,N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.,"Is the triple ""ELOSULFASE ALFA related to mucopolysaccharidosis type 4"" supported by the sentence: ""N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.""?",False, +26291786,ELOSULFASE ALFA derives from Keratan,4517,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, +26291786,ELOSULFASE ALFA derives from Keratan,4518,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, +16241796,ELOSULFASE ALFA physically interacts with Keratan,4519,"The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA physically interacts with Keratan"" supported by the sentence: ""The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, +16652816,ELOSULFASE ALFA causes mucopolysaccharidosis type 4,4520,PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.,"Is the triple ""ELOSULFASE ALFA causes mucopolysaccharidosis type 4"" supported by the sentence: ""PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.""?",False, +13130107,ELOSULFASE ALFA affects Keratan,4521,"Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA affects Keratan"" supported by the sentence: ""Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, +21593588,Pegvaliase related to phenylketonuria,4522,Case-control study about the acceptance of Pegvaliase in Phenylketonuria.,"Is the triple ""Pegvaliase related to phenylketonuria"" supported by the sentence: ""Case-control study about the acceptance of Pegvaliase in Phenylketonuria.""?",False, +23111774,Labetalol related to preeclampsia,4523,"To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.","Is the triple ""Labetalol related to preeclampsia"" supported by the sentence: ""To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.""?",False, +19865755,Labetalol related to hypertensive disorder,4524,"Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.","Is the triple ""Labetalol related to hypertensive disorder"" supported by the sentence: ""Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.""?",False, +19886747,Labetalol causes hypertensive disorder,4525,Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.,"Is the triple ""Labetalol causes hypertensive disorder"" supported by the sentence: ""Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.""?",False, +7968423,Labetalol causes hypotensive disorder,4526,"For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.","Is the triple ""Labetalol causes hypotensive disorder"" supported by the sentence: ""For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.""?",False, +26371124,Labetalol affects hypertensive disorder,4527,The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.""?",False, +16245918,Labetalol affects stroke disorder,4528,"BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.","Is the triple ""Labetalol affects stroke disorder"" supported by the sentence: ""BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.""?",False, +15472186,Labetalol affects hypertensive disorder,4529,The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.""?",False, +11424839,Labetalol affects hypotensive disorder,4530,The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.,"Is the triple ""Labetalol affects hypotensive disorder"" supported by the sentence: ""The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.""?",False, +24194004,Labetalol prevents preeclampsia,4531,"CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.","Is the triple ""Labetalol prevents preeclampsia"" supported by the sentence: ""CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.""?",False, +16282554,Labetalol prevents hypertensive disorder,4532,"Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.","Is the triple ""Labetalol prevents hypertensive disorder"" supported by the sentence: ""Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.""?",False, +16892434,Labetalol predisposes stroke disorder,4533,"Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.","Is the triple ""Labetalol predisposes stroke disorder"" supported by the sentence: ""Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.""?",False, +15232781,Carvedilol related to hypertensive disorder,4534,Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.,"Is the triple ""Carvedilol related to hypertensive disorder"" supported by the sentence: ""Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.""?",False, +15407113,Carvedilol causes Left ventricular hypertrophy,4535,Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.,"Is the triple ""Carvedilol causes Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.""?",False, +14049404,Carvedilol causes epilepsy,4536,Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.,"Is the triple ""Carvedilol causes epilepsy"" supported by the sentence: ""Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.""?",False, +19046224,Carvedilol affects esophageal varices,4537,Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.,"Is the triple ""Carvedilol affects esophageal varices"" supported by the sentence: ""Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.""?",False, +17542363,Carvedilol affects Left ventricular hypertrophy,4538,"Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.""?",False, +11530189,Carvedilol affects essential hypertension,4539,Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.,"Is the triple ""Carvedilol affects essential hypertension"" supported by the sentence: ""Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.""?",False, +11200172,Carvedilol affects atrial fibrillation,4540,Role of carvedilol in atrial fibrillation: insights from clinical trials.,"Is the triple ""Carvedilol affects atrial fibrillation"" supported by the sentence: ""Role of carvedilol in atrial fibrillation: insights from clinical trials.""?",False, +10614289,Carvedilol affects Stable angina,4541,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects Stable angina"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, +10614288,Carvedilol affects hypertensive disorder,4542,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, +10402879,Carvedilol affects hypertensive disorder,4543,"In addition, carvedilol reduced elevated blood pressure in allografted rats.","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""In addition, carvedilol reduced elevated blood pressure in allografted rats.""?",False, +9269217,Carvedilol affects Left ventricular hypertrophy,4544,"Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.""?",False, +9116913,Carvedilol affects cardiovascular disorder,4545,All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.,"Is the triple ""Carvedilol affects cardiovascular disorder"" supported by the sentence: ""All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.""?",False, +7256243,Carvedilol affects portal hypertension,4546,BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.,"Is the triple ""Carvedilol affects portal hypertension"" supported by the sentence: ""BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.""?",False, +24587957,Carvedilol disrupts portal hypertension,4547,"Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.","Is the triple ""Carvedilol disrupts portal hypertension"" supported by the sentence: ""Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.""?",False, +21108262,Carvedilol disrupts myocardial infarction,4548,"The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.","Is the triple ""Carvedilol disrupts myocardial infarction"" supported by the sentence: ""The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.""?",False, +13210472,Carvedilol disrupts atrial fibrillation,4549,"The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.","Is the triple ""Carvedilol disrupts atrial fibrillation"" supported by the sentence: ""The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.""?",False, +23631897,Carvedilol prevents neoplasm,4550,Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.,"Is the triple ""Carvedilol prevents neoplasm"" supported by the sentence: ""Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.""?",False, +23413400,Carvedilol prevents myocardial infarction,4551,Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.,"Is the triple ""Carvedilol prevents myocardial infarction"" supported by the sentence: ""Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.""?",False, +20796578,Carvedilol prevents hypoglycemia,4552,"To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.","Is the triple ""Carvedilol prevents hypoglycemia"" supported by the sentence: ""To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.""?",False, +17416516,Carvedilol prevents portal hypertension,4553,CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.,"Is the triple ""Carvedilol prevents portal hypertension"" supported by the sentence: ""CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.""?",False, +15996194,Carvedilol prevents hypertensive disorder,4554,Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.,"Is the triple ""Carvedilol prevents hypertensive disorder"" supported by the sentence: ""Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.""?",False, +15794060,Carvedilol prevents Abnormal left ventricular function,4555,Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.,"Is the triple ""Carvedilol prevents Abnormal left ventricular function"" supported by the sentence: ""Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.""?",False, +15707001,Carvedilol prevents kidney disorder,4556,"Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.","Is the triple ""Carvedilol prevents kidney disorder"" supported by the sentence: ""Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.""?",False, +12564717,Carvedilol prevents atrial fibrillation,4557,Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).,"Is the triple ""Carvedilol prevents atrial fibrillation"" supported by the sentence: ""Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).""?",False, +8686828,Carvedilol prevents Left ventricular hypertrophy,4558,Carvedilol reduced LVH by 20%.,"Is the triple ""Carvedilol prevents Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol reduced LVH by 20%.""?",False, +23747042,Carvedilol predisposes type 2 diabetes mellitus,4559,"However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.","Is the triple ""Carvedilol predisposes type 2 diabetes mellitus"" supported by the sentence: ""However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.""?",False, +22663350,Carvedilol predisposes atrial fibrillation,4560,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Carvedilol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, +21640789,Carvedilol predisposes hypoglycemia,4561,"This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.","Is the triple ""Carvedilol predisposes hypoglycemia"" supported by the sentence: ""This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.""?",False, +21331523,Carvedilol predisposes myocardial infarction,4562,The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).,"Is the triple ""Carvedilol predisposes myocardial infarction"" supported by the sentence: ""The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).""?",False, +20291576,Raloxifene related to schizophrenia,4563,A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.,"Is the triple ""Raloxifene related to schizophrenia"" supported by the sentence: ""A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.""?",False, +13558027,Raloxifene related to postmenopausal osteoporosis,4564,Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.,"Is the triple ""Raloxifene related to postmenopausal osteoporosis"" supported by the sentence: ""Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.""?",False, +27583128,Raloxifene causes breast neoplasm,4565,Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.,"Is the triple ""Raloxifene causes breast neoplasm"" supported by the sentence: ""Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.""?",False, +20242808,Raloxifene affects psychotic disorder,4566,"In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.","Is the triple ""Raloxifene affects psychotic disorder"" supported by the sentence: ""In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.""?",False, +16098538,Raloxifene affects schizophrenia,4567,Beneficial effects of add-on raloxifene in schizophrenia.,"Is the triple ""Raloxifene affects schizophrenia"" supported by the sentence: ""Beneficial effects of add-on raloxifene in schizophrenia.""?",False, +15267794,Raloxifene affects Marchiafava-Bignami disease,4568,"To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.","Is the triple ""Raloxifene affects Marchiafava-Bignami disease"" supported by the sentence: ""To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.""?",False, +11233936,Raloxifene affects breast neoplasm,4569,"OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.","Is the triple ""Raloxifene affects breast neoplasm"" supported by the sentence: ""OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.""?",False, +10869334,Raloxifene affects osteoporosis,4570,"While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.","Is the triple ""Raloxifene affects osteoporosis"" supported by the sentence: ""While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.""?",False, +9569313,Raloxifene affects postmenopausal osteoporosis,4571,"Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.","Is the triple ""Raloxifene affects postmenopausal osteoporosis"" supported by the sentence: ""Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.""?",False, +15267792,Raloxifene disrupts Marchiafava-Bignami disease,4572,Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.,"Is the triple ""Raloxifene disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.""?",False, +13369623,Raloxifene disrupts osteoporosis,4573,Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.,"Is the triple ""Raloxifene disrupts osteoporosis"" supported by the sentence: ""Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.""?",False, +7874352,Raloxifene disrupts postmenopausal osteoporosis,4574,The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.,"Is the triple ""Raloxifene disrupts postmenopausal osteoporosis"" supported by the sentence: ""The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.""?",False, +16984197,Raloxifene prevents Alzheimer disease,4575,"We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.","Is the triple ""Raloxifene prevents Alzheimer disease"" supported by the sentence: ""We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.""?",False, +12036378,Raloxifene prevents breast neoplasm,4576,"We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.","Is the triple ""Raloxifene prevents breast neoplasm"" supported by the sentence: ""We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.""?",False, +7813032,Raloxifene prevents postmenopausal osteoporosis,4577,Raloxifene to prevent postmenopausal osteoporosis.,"Is the triple ""Raloxifene prevents postmenopausal osteoporosis"" supported by the sentence: ""Raloxifene to prevent postmenopausal osteoporosis.""?",False, +7578651,Raloxifene prevents osteoporosis,4578,"Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.","Is the triple ""Raloxifene prevents osteoporosis"" supported by the sentence: ""Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.""?",False, +7570810,Raloxifene prevents Marchiafava-Bignami disease,4579,RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.,"Is the triple ""Raloxifene prevents Marchiafava-Bignami disease"" supported by the sentence: ""RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.""?",False, +11746046,Raloxifene predisposes Alzheimer disease,4580,"OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.","Is the triple ""Raloxifene predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.""?",False, +11350173,Raloxifene predisposes osteoporosis,4581,"Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.","Is the triple ""Raloxifene predisposes osteoporosis"" supported by the sentence: ""Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.""?",False, +23481448,Bazedoxifene acetate prevents osteoporosis,4582,"These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.","Is the triple ""Bazedoxifene acetate prevents osteoporosis"" supported by the sentence: ""These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.""?",False, +19905553,Ospemifene disrupts psychologic dyspareunia,4583,"In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.","Is the triple ""Ospemifene disrupts psychologic dyspareunia"" supported by the sentence: ""In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.""?",False, +15516940,Sufentanil affects Pain,4584,The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.,"Is the triple ""Sufentanil affects Pain"" supported by the sentence: ""The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.""?",False, +20743116,Sufentanil prevents delirium,4585,"CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.","Is the triple ""Sufentanil prevents delirium"" supported by the sentence: ""CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.""?",False, +8151024,Sufentanil prevents Pain,4586,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Sufentanil prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, +12819365,Streptomycin related to Buruli ulcer disease,4587,The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.,"Is the triple ""Streptomycin related to Buruli ulcer disease"" supported by the sentence: ""The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.""?",False, +11425591,Streptomycin related to osteomyelitis,4588,Streptomycin in chronic traumatic osteomyelitis.,"Is the triple ""Streptomycin related to osteomyelitis"" supported by the sentence: ""Streptomycin in chronic traumatic osteomyelitis.""?",False, +10417352,Streptomycin related to plague,4589,Role of streptomycin in plague.,"Is the triple ""Streptomycin related to plague"" supported by the sentence: ""Role of streptomycin in plague.""?",False, +10748245,Streptomycin causes plague,4590,[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].,"Is the triple ""Streptomycin causes plague"" supported by the sentence: ""[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].""?",False, +26655494,Streptomycin prevents mycobacterium avium complex disease,4591,"Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.","Is the triple ""Streptomycin prevents mycobacterium avium complex disease"" supported by the sentence: ""Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.""?",False, +14226518,Paromomycin related to cutaneous leishmaniasis,4592,"In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).","Is the triple ""Paromomycin related to cutaneous leishmaniasis"" supported by the sentence: ""In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).""?",False, +12550860,Paromomycin related to visceral leishmaniasis,4593,"Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.","Is the triple ""Paromomycin related to visceral leishmaniasis"" supported by the sentence: ""Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.""?",False, +24692385,Paromomycin affects leishmaniasis,4594,"Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.","Is the triple ""Paromomycin affects leishmaniasis"" supported by the sentence: ""Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.""?",False, +23700620,Paromomycin affects visceral leishmaniasis,4595,The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.,"Is the triple ""Paromomycin affects visceral leishmaniasis"" supported by the sentence: ""The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.""?",False, +22567030,Paromomycin affects cutaneous leishmaniasis,4596,"Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.","Is the triple ""Paromomycin affects cutaneous leishmaniasis"" supported by the sentence: ""Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.""?",False, +27729096,Kanamycin related to bacterial infectious disease,4597,The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.,"Is the triple ""Kanamycin related to bacterial infectious disease"" supported by the sentence: ""The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.""?",False, +10553348,Kanamycin related to tuberculosis,4598,Kanamycin in experimental guinea pig tuberculosis.,"Is the triple ""Kanamycin related to tuberculosis"" supported by the sentence: ""Kanamycin in experimental guinea pig tuberculosis.""?",False, +10567002,Kanamycin affects tuberculosis,4599,Effects of kanamycin in experimental tuberculosis of guinea pigs.,"Is the triple ""Kanamycin affects tuberculosis"" supported by the sentence: ""Effects of kanamycin in experimental tuberculosis of guinea pigs.""?",False, +25418796,Vancomycin related to ulcerative colitis,4600,Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.,"Is the triple ""Vancomycin related to ulcerative colitis"" supported by the sentence: ""Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.""?",False, +24528866,Vancomycin related to bacterial infectious disease,4601,"Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.","Is the triple ""Vancomycin related to bacterial infectious disease"" supported by the sentence: ""Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.""?",False, +23989025,Vancomycin related to Inflammation,4602,"The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.""?",False, +22667296,Vancomycin related to arthropathy,4603,"Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).","Is the triple ""Vancomycin related to arthropathy"" supported by the sentence: ""Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).""?",False, +21740759,Vancomycin related to Infection,4604,"Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.""?",False, +20543239,Vancomycin related to hematopoietic and lymphoid system neoplasm,4605,"Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.","Is the triple ""Vancomycin related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.""?",False, +20099844,Vancomycin related to cystic fibrosis,4606,Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.,"Is the triple ""Vancomycin related to cystic fibrosis"" supported by the sentence: ""Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.""?",False, +18717834,Vancomycin related to eye infectious disorder,4607,"MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.","Is the triple ""Vancomycin related to eye infectious disorder"" supported by the sentence: ""MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.""?",False, +18563763,Vancomycin related to staphylococcal pneumonia,4608,No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.,"Is the triple ""Vancomycin related to staphylococcal pneumonia"" supported by the sentence: ""No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.""?",False, +17578296,Vancomycin related to Peptidoglycan,4609,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, +17578296,Vancomycin related to Peptidoglycan,4610,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, +15843803,Vancomycin related to Diabetic Foot,4611,"With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.","Is the triple ""Vancomycin related to Diabetic Foot"" supported by the sentence: ""With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.""?",False, +15502624,Vancomycin related to abscess,4612,Vancomycin and ciprofloxacin levels were inadequate in most abscesses.,"Is the triple ""Vancomycin related to abscess"" supported by the sentence: ""Vancomycin and ciprofloxacin levels were inadequate in most abscesses.""?",False, +15448370,Vancomycin related to obesity disorder,4613,There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).,"Is the triple ""Vancomycin related to obesity disorder"" supported by the sentence: ""There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).""?",False, +15389679,Vancomycin related to osteomyelitis,4614,Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.,"Is the triple ""Vancomycin related to osteomyelitis"" supported by the sentence: ""Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.""?",False, +15008716,Vancomycin related to peritonitis,4615,CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.""?",False, +14607992,Vancomycin related to pneumonia,4616,"Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.","Is the triple ""Vancomycin related to pneumonia"" supported by the sentence: ""Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.""?",False, +14564943,Vancomycin related to gram-positive bacterial infections,4617,"Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.","Is the triple ""Vancomycin related to gram-positive bacterial infections"" supported by the sentence: ""Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.""?",False, +11348824,Vancomycin related to kidney failure,4618,"The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.","Is the triple ""Vancomycin related to kidney failure"" supported by the sentence: ""The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.""?",False, +11195361,Vancomycin related to Neonatal sepsis,4619,"Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.","Is the triple ""Vancomycin related to Neonatal sepsis"" supported by the sentence: ""Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.""?",False, +10946982,Vancomycin related to respiratory tract infectious disorder,4620,This may give linezolid an advantage over vancomycin in certain respiratory infections.,"Is the triple ""Vancomycin related to respiratory tract infectious disorder"" supported by the sentence: ""This may give linezolid an advantage over vancomycin in certain respiratory infections.""?",False, +10225522,Vancomycin related to bacterial infectious disease with sepsis,4621,These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.,"Is the triple ""Vancomycin related to bacterial infectious disease with sepsis"" supported by the sentence: ""These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.""?",False, +9057886,Vancomycin related to nosocomial infection,4622,A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.,"Is the triple ""Vancomycin related to nosocomial infection"" supported by the sentence: ""A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.""?",False, +9057885,Vancomycin related to staphylococcal infection,4623,Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.,"Is the triple ""Vancomycin related to staphylococcal infection"" supported by the sentence: ""Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.""?",False, +8859000,Vancomycin related to endocarditis,4624,"Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.","Is the triple ""Vancomycin related to endocarditis"" supported by the sentence: ""Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.""?",False, +8170422,Vancomycin related to Sepsis,4625,"DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.","Is the triple ""Vancomycin related to Sepsis"" supported by the sentence: ""DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.""?",False, +23445509,Vancomycin related to peritonitis,4626,Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.""?",False, +22719539,Vancomycin related to Infection,4627,"For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).""?",False, +11098147,Vancomycin related to Inflammation,4628,"Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.""?",False, +14094746,Vancomycin coexists with Peptidoglycan,4629,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, +14094746,Vancomycin coexists with Peptidoglycan,4630,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, +7840667,Vancomycin physically interacts with Peptidoglycan,4631,Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.,"Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.""?",False, +7710804,Vancomycin physically interacts with Peptidoglycan,4632,"The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.","Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.""?",False, +26896148,Vancomycin causes endocarditis,4633,Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.,"Is the triple ""Vancomycin causes endocarditis"" supported by the sentence: ""Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.""?",False, +26320414,Vancomycin causes enterocolitis,4634,"Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.","Is the triple ""Vancomycin causes enterocolitis"" supported by the sentence: ""Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.""?",False, +22849619,Vancomycin causes Infection,4635,"Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).","Is the triple ""Vancomycin causes Infection"" supported by the sentence: ""Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).""?",False, +22231760,Vancomycin causes Inflammation,4636,"Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.","Is the triple ""Vancomycin causes Inflammation"" supported by the sentence: ""Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.""?",False, +21632936,Vancomycin causes bacterial infectious disease with sepsis,4637,"Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.","Is the triple ""Vancomycin causes bacterial infectious disease with sepsis"" supported by the sentence: ""Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.""?",False, +18945219,Vancomycin causes peritonitis,4638,A literature search identified one other published report of vancomycin-induced EP.,"Is the triple ""Vancomycin causes peritonitis"" supported by the sentence: ""A literature search identified one other published report of vancomycin-induced EP.""?",False, +15481792,Vancomycin causes skin disorder,4639,We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.,"Is the triple ""Vancomycin causes skin disorder"" supported by the sentence: ""We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.""?",False, +12001625,Vancomycin causes kidney failure,4640,"The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.","Is the triple ""Vancomycin causes kidney failure"" supported by the sentence: ""The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.""?",False, +9570250,Vancomycin causes nosocomial infection,4641,Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.,"Is the triple ""Vancomycin causes nosocomial infection"" supported by the sentence: ""Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.""?",False, +23893373,Vancomycin affects Infection,4642,"CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.""?",False, +21581118,Vancomycin affects Infection,4643,"As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.""?",False, +21291384,Vancomycin affects hematopoietic and lymphoid system neoplasm,4644,"In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.","Is the triple ""Vancomycin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.""?",False, +20283933,Vancomycin affects enterocolitis,4645,"Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.","Is the triple ""Vancomycin affects enterocolitis"" supported by the sentence: ""Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.""?",False, +19879029,Vancomycin affects cystic fibrosis,4646,"Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.","Is the triple ""Vancomycin affects cystic fibrosis"" supported by the sentence: ""Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.""?",False, +16899271,Vancomycin affects Sepsis,4647,"CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.""?",False, +15270589,Vancomycin affects peritonitis,4648,Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.,"Is the triple ""Vancomycin affects peritonitis"" supported by the sentence: ""Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.""?",False, +13735180,Vancomycin affects pneumonia,4649,"Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.","Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.""?",False, +12348278,Vancomycin affects Sepsis,4650,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, +12348277,Vancomycin affects osteomyelitis,4651,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects osteomyelitis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, +12348276,Vancomycin affects endocarditis,4652,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects endocarditis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, +7991855,Vancomycin affects Peptidoglycan,4653,These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.,"Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.""?",False, +7527991,Vancomycin affects pneumonia,4654,The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.,"Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.""?",False, +17707788,Vancomycin affects Peptidoglycan,4655,"In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.","Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.""?",False, +22719533,Vancomycin disrupts Infection,4656,We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.,"Is the triple ""Vancomycin disrupts Infection"" supported by the sentence: ""We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.""?",False, +21036263,Vancomycin disrupts osteomyelitis,4657,"More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.","Is the triple ""Vancomycin disrupts osteomyelitis"" supported by the sentence: ""More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.""?",False, +19924841,Vancomycin disrupts Inflammation,4658,"More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.","Is the triple ""Vancomycin disrupts Inflammation"" supported by the sentence: ""More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.""?",False, +14538194,Vancomycin disrupts enterocolitis,4659,"Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.","Is the triple ""Vancomycin disrupts enterocolitis"" supported by the sentence: ""Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.""?",False, +21888394,Vancomycin prevents bacterial infectious disease,4660,"Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.","Is the triple ""Vancomycin prevents bacterial infectious disease"" supported by the sentence: ""Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.""?",False, +21518539,Vancomycin prevents Infection,4661,Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .,"Is the triple ""Vancomycin prevents Infection"" supported by the sentence: ""Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .""?",False, +21292683,Vancomycin prevents osteomyelitis,4662,"CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.","Is the triple ""Vancomycin prevents osteomyelitis"" supported by the sentence: ""CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.""?",False, +20759704,Vancomycin prevents kidney failure,4663,Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.,"Is the triple ""Vancomycin prevents kidney failure"" supported by the sentence: ""Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.""?",False, +20759520,Vancomycin prevents arthropathy,4664,"Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.","Is the triple ""Vancomycin prevents arthropathy"" supported by the sentence: ""Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.""?",False, +16424860,Vancomycin prevents pneumonia,4665,"Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.","Is the triple ""Vancomycin prevents pneumonia"" supported by the sentence: ""Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.""?",False, +11136130,Vancomycin prevents nosocomial infection,4666,"Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.","Is the triple ""Vancomycin prevents nosocomial infection"" supported by the sentence: ""Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.""?",False, +8520533,Vancomycin prevents peritonitis,4667,The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.,"Is the triple ""Vancomycin prevents peritonitis"" supported by the sentence: ""The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.""?",False, +8203212,Vancomycin prevents endocarditis,4668,"Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.","Is the triple ""Vancomycin prevents endocarditis"" supported by the sentence: ""Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.""?",False, +8170423,Vancomycin prevents Neonatal sepsis,4669,MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.,"Is the triple ""Vancomycin prevents Neonatal sepsis"" supported by the sentence: ""MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.""?",False, +8170420,Vancomycin prevents Sepsis,4670,REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.,"Is the triple ""Vancomycin prevents Sepsis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.""?",False, +7111089,Vancomycin prevents Inflammation,4671,We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.,"Is the triple ""Vancomycin prevents Inflammation"" supported by the sentence: ""We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.""?",False, +25178384,Vancomycin exacerbates Inflammation,4672,"Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.","Is the triple ""Vancomycin exacerbates Inflammation"" supported by the sentence: ""Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.""?",False, +21622859,Vancomycin exacerbates pneumonia,4673,The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.,"Is the triple ""Vancomycin exacerbates pneumonia"" supported by the sentence: ""The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.""?",False, +21314122,Vancomycin predisposes Sepsis,4674,"OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.","Is the triple ""Vancomycin predisposes Sepsis"" supported by the sentence: ""OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.""?",False, +19879549,Vancomycin predisposes kidney failure,4675,"Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.","Is the triple ""Vancomycin predisposes kidney failure"" supported by the sentence: ""Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.""?",False, +18555479,Vancomycin predisposes pneumonia,4676,"Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.","Is the triple ""Vancomycin predisposes pneumonia"" supported by the sentence: ""Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.""?",False, +18327103,Vancomycin predisposes nosocomial infection,4677,"CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.","Is the triple ""Vancomycin predisposes nosocomial infection"" supported by the sentence: ""CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.""?",False, +12689487,Vancomycin predisposes bacterial infectious disease with sepsis,4678,"CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.","Is the triple ""Vancomycin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.""?",False, +12018679,LENOGRASTIM related to plasma cell myeloma,4679,We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.,"Is the triple ""LENOGRASTIM related to plasma cell myeloma"" supported by the sentence: ""We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.""?",False, +24207855,SARGRAMOSTIM related to pulmonary alveolar proteinosis,4680,NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.,"Is the triple ""SARGRAMOSTIM related to pulmonary alveolar proteinosis"" supported by the sentence: ""NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.""?",False, +23712911,SARGRAMOSTIM related to Sepsis,4681,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to Sepsis"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, +23712910,SARGRAMOSTIM related to adult acute respiratory distress syndrome,4682,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to adult acute respiratory distress syndrome"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, +23177848,SARGRAMOSTIM related to Alzheimer disease,4683,An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.,"Is the triple ""SARGRAMOSTIM related to Alzheimer disease"" supported by the sentence: ""An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.""?",False, +16827749,SARGRAMOSTIM related to prostate cancer,4684,Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.,"Is the triple ""SARGRAMOSTIM related to prostate cancer"" supported by the sentence: ""Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.""?",False, +11846978,SARGRAMOSTIM related to Crohn disease,4685,Preliminary studies suggest sargramostim may have activity in Crohn's disease.,"Is the triple ""SARGRAMOSTIM related to Crohn disease"" supported by the sentence: ""Preliminary studies suggest sargramostim may have activity in Crohn's disease.""?",False, +7671811,SARGRAMOSTIM related to HIV infectious disease,4686,"Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.","Is the triple ""SARGRAMOSTIM related to HIV infectious disease"" supported by the sentence: ""Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.""?",False, +7896656,SARGRAMOSTIM prevents neutropenia,4687,Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.,"Is the triple ""SARGRAMOSTIM prevents neutropenia"" supported by the sentence: ""Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.""?",False, +27611311,Filgrastim related to sarcoma,4688,Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.,"Is the triple ""Filgrastim related to sarcoma"" supported by the sentence: ""Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.""?",False, +26602673,Filgrastim related to acute lymphoblastic leukemia,4689,Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.,"Is the triple ""Filgrastim related to acute lymphoblastic leukemia"" supported by the sentence: ""Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.""?",False, +26505391,Filgrastim related to Hodgkins lymphoma,4690,"CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.","Is the triple ""Filgrastim related to Hodgkins lymphoma"" supported by the sentence: ""CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.""?",False, +23038064,Filgrastim related to Infection,4691,"RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.","Is the triple ""Filgrastim related to Infection"" supported by the sentence: ""RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.""?",False, +22749433,Filgrastim related to neoplasm,4692,"Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.","Is the triple ""Filgrastim related to neoplasm"" supported by the sentence: ""Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.""?",False, +19713781,Filgrastim related to lymphoma,4693,A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.,"Is the triple ""Filgrastim related to lymphoma"" supported by the sentence: ""A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.""?",False, +18903615,Filgrastim related to HIV infectious disease,4694,"Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.","Is the triple ""Filgrastim related to HIV infectious disease"" supported by the sentence: ""Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.""?",False, +17402873,Filgrastim related to acute myeloid leukemia,4695,"Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.","Is the triple ""Filgrastim related to acute myeloid leukemia"" supported by the sentence: ""Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.""?",False, +16080456,Filgrastim related to plasma cell myeloma,4696,"Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).","Is the triple ""Filgrastim related to plasma cell myeloma"" supported by the sentence: ""Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).""?",False, +14467347,Filgrastim related to myocardial infarction,4697,"Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.","Is the triple ""Filgrastim related to myocardial infarction"" supported by the sentence: ""Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.""?",False, +13860825,Filgrastim related to small cell lung carcinoma,4698,Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.,"Is the triple ""Filgrastim related to small cell lung carcinoma"" supported by the sentence: ""Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.""?",False, +10253688,Filgrastim related to ovarian cancer,4699,"Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.","Is the triple ""Filgrastim related to ovarian cancer"" supported by the sentence: ""Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.""?",False, +9334871,Filgrastim related to non-small cell lung carcinoma,4700,"A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.","Is the triple ""Filgrastim related to non-small cell lung carcinoma"" supported by the sentence: ""A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.""?",False, +7868897,Filgrastim related to neutropenia,4701,"Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.","Is the triple ""Filgrastim related to neutropenia"" supported by the sentence: ""Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.""?",False, +7775323,Filgrastim related to non-Hodgkin lymphoma,4702,Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.,"Is the triple ""Filgrastim related to non-Hodgkin lymphoma"" supported by the sentence: ""Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.""?",False, +13176527,Filgrastim has part non-Hodgkin lymphoma,4703,Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.,"Is the triple ""Filgrastim has part non-Hodgkin lymphoma"" supported by the sentence: ""Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.""?",False, +27488127,Filgrastim causes acute myeloid leukemia,4704,"The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.","Is the triple ""Filgrastim causes acute myeloid leukemia"" supported by the sentence: ""The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.""?",False, +26596932,Filgrastim causes acute lymphoblastic leukemia,4705,Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.,"Is the triple ""Filgrastim causes acute lymphoblastic leukemia"" supported by the sentence: ""Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.""?",False, +19245347,Filgrastim causes myeloproliferative neoplasm,4706,Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.,"Is the triple ""Filgrastim causes myeloproliferative neoplasm"" supported by the sentence: ""Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.""?",False, +8419399,Filgrastim causes neutropenia,4707,Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.,"Is the triple ""Filgrastim causes neutropenia"" supported by the sentence: ""Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.""?",False, +26496059,Filgrastim affects neutropenia,4708,"The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.","Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.""?",False, +15351355,Filgrastim affects Fever,4709,"Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.","Is the triple ""Filgrastim affects Fever"" supported by the sentence: ""Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.""?",False, +7868413,Filgrastim affects neutropenia,4710,Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.,"Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.""?",False, +9501874,Filgrastim disrupts neutropenia,4711,Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.,"Is the triple ""Filgrastim disrupts neutropenia"" supported by the sentence: ""Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.""?",False, +14309803,Filgrastim prevents non-Hodgkin lymphoma,4712,"The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).","Is the triple ""Filgrastim prevents non-Hodgkin lymphoma"" supported by the sentence: ""The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).""?",False, +7265196,Filgrastim prevents neutropenia,4713,We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.,"Is the triple ""Filgrastim prevents neutropenia"" supported by the sentence: ""We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.""?",False, +16134815,Filgrastim predisposes hematopoietic and lymphoid system neoplasm,4714,BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.,"Is the triple ""Filgrastim predisposes hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.""?",False, +14495646,Filgrastim predisposes neutropenia,4715,"Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.","Is the triple ""Filgrastim predisposes neutropenia"" supported by the sentence: ""Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.""?",False, +12306052,Tibolone affects physiological sexual disorder,4716,"Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.","Is the triple ""Tibolone affects physiological sexual disorder"" supported by the sentence: ""Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.""?",False, +7873396,Tibolone prevents osteoporosis,4717,"In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.","Is the triple ""Tibolone prevents osteoporosis"" supported by the sentence: ""In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.""?",False, +17565484,Cosyntropin affects West syndrome,4718,"TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.","Is the triple ""Cosyntropin affects West syndrome"" supported by the sentence: ""TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.""?",False, +11757081,Cosyntropin disrupts hypertensive disorder,4719,In one child synthetic ACTH was stopped because of arterial hypertension.,"Is the triple ""Cosyntropin disrupts hypertensive disorder"" supported by the sentence: ""In one child synthetic ACTH was stopped because of arterial hypertension.""?",False, +19585114,Corticotropin related to chronic progressive multiple sclerosis,4720,Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.,"Is the triple ""Corticotropin related to chronic progressive multiple sclerosis"" supported by the sentence: ""Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.""?",False, +15839924,Corticotropin related to membranous glomerulonephritis,4721,The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.,"Is the triple ""Corticotropin related to membranous glomerulonephritis"" supported by the sentence: ""The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.""?",False, +10947313,Corticotropin related to polycystic ovary syndrome,4722,"CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.","Is the triple ""Corticotropin related to polycystic ovary syndrome"" supported by the sentence: ""CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.""?",False, +10518316,Corticotropin related to dermatomyositis,4723,Corticotrophin and cortisone therapy in dermatomyositis.,"Is the triple ""Corticotropin related to dermatomyositis"" supported by the sentence: ""Corticotrophin and cortisone therapy in dermatomyositis.""?",False, +10489579,Corticotropin related to epilepsy,4724,[Observations on several cases of epilepsy in children with ACTH and cortisone].,"Is the triple ""Corticotropin related to epilepsy"" supported by the sentence: ""[Observations on several cases of epilepsy in children with ACTH and cortisone].""?",False, +10438408,Corticotropin related to nephrotic syndrome,4725,Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.,"Is the triple ""Corticotropin related to nephrotic syndrome"" supported by the sentence: ""Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.""?",False, +10431205,Corticotropin related to sarcoidosis,4726,[ACTH and cortisone in sarcoidosis; preliminary report].,"Is the triple ""Corticotropin related to sarcoidosis"" supported by the sentence: ""[ACTH and cortisone in sarcoidosis; preliminary report].""?",False, +10427009,Corticotropin related to optic neuritis,4727,Intravenous use of corticotropin in optic neuritis.,"Is the triple ""Corticotropin related to optic neuritis"" supported by the sentence: ""Intravenous use of corticotropin in optic neuritis.""?",False, +9718321,Corticotropin related to rheumatoid arthritis,4728,"ACTH, cortisol and prolactin in active rheumatoid arthritis.","Is the triple ""Corticotropin related to rheumatoid arthritis"" supported by the sentence: ""ACTH, cortisol and prolactin in active rheumatoid arthritis.""?",False, +8496620,Corticotropin related to multiple sclerosis,4729,Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.,"Is the triple ""Corticotropin related to multiple sclerosis"" supported by the sentence: ""Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.""?",False, +7394246,Corticotropin related to West syndrome,4730,ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.,"Is the triple ""Corticotropin related to West syndrome"" supported by the sentence: ""ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.""?",False, +22849896,Corticotropin causes West syndrome,4731,Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.,"Is the triple ""Corticotropin causes West syndrome"" supported by the sentence: ""Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.""?",False, +12436107,Corticotropin causes epilepsy,4732,"The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.","Is the triple ""Corticotropin causes epilepsy"" supported by the sentence: ""The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.""?",False, +11010111,Corticotropin causes rheumatoid arthritis,4733,The natural course of rheumatoid arthritis and the changes induced by ACTH.,"Is the triple ""Corticotropin causes rheumatoid arthritis"" supported by the sentence: ""The natural course of rheumatoid arthritis and the changes induced by ACTH.""?",False, +17565428,Corticotropin affects West syndrome,4734,Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.,"Is the triple ""Corticotropin affects West syndrome"" supported by the sentence: ""Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.""?",False, +15783986,Corticotropin affects multiple sclerosis,4735,"At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.","Is the triple ""Corticotropin affects multiple sclerosis"" supported by the sentence: ""At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.""?",False, +15695412,Corticotropin affects polycystic ovary syndrome,4736,Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.,"Is the triple ""Corticotropin affects polycystic ovary syndrome"" supported by the sentence: ""Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.""?",False, +11427275,Corticotropin affects dermatomyositis,4737,The effect of pituitary adrenocorticotropin in dermatomyositis.,"Is the triple ""Corticotropin affects dermatomyositis"" supported by the sentence: ""The effect of pituitary adrenocorticotropin in dermatomyositis.""?",False, +10737513,Corticotropin affects sarcoidosis,4738,The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).,"Is the triple ""Corticotropin affects sarcoidosis"" supported by the sentence: ""The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).""?",False, +10422766,Corticotropin affects rheumatoid arthritis,4739,On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.,"Is the triple ""Corticotropin affects rheumatoid arthritis"" supported by the sentence: ""On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.""?",False, +9312832,Corticotropin affects epilepsy,4740,"The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).","Is the triple ""Corticotropin affects epilepsy"" supported by the sentence: ""The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).""?",False, +15159690,Corticotropin disrupts epilepsy,4741,AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.,"Is the triple ""Corticotropin disrupts epilepsy"" supported by the sentence: ""AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.""?",False, +27033387,Corticotropin prevents West syndrome,4742,Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.,"Is the triple ""Corticotropin prevents West syndrome"" supported by the sentence: ""Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.""?",False, +10517176,Corticotropin prevents epilepsy,4743,"Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.","Is the triple ""Corticotropin prevents epilepsy"" supported by the sentence: ""Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.""?",False, +23224982,Corticotropin predisposes epilepsy,4744,"The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.","Is the triple ""Corticotropin predisposes epilepsy"" supported by the sentence: ""The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.""?",False, +15800284,Dabigatran etexilate related to atrial fibrillation,4745,"In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.","Is the triple ""Dabigatran etexilate related to atrial fibrillation"" supported by the sentence: ""In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.""?",False, +16972150,Dabigatran etexilate affects stroke disorder,4746,This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.,"Is the triple ""Dabigatran etexilate affects stroke disorder"" supported by the sentence: ""This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.""?",False, +21262475,Dabigatran etexilate prevents thrombophilia due to thrombin defect,4747,Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.,"Is the triple ""Dabigatran etexilate prevents thrombophilia due to thrombin defect"" supported by the sentence: ""Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.""?",False, +19084221,Dabigatran etexilate prevents thrombotic disease,4748,"A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.","Is the triple ""Dabigatran etexilate prevents thrombotic disease"" supported by the sentence: ""A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.""?",False, +14524874,Dabigatran etexilate prevents stroke disorder,4749,"Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.","Is the triple ""Dabigatran etexilate prevents stroke disorder"" supported by the sentence: ""Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.""?",False, +11599698,Dabigatran etexilate prevents Thromboembolism,4750,"A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.","Is the triple ""Dabigatran etexilate prevents Thromboembolism"" supported by the sentence: ""A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.""?",False, +15929248,Dabigatran etexilate predisposes stroke disorder,4751,"Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.","Is the triple ""Dabigatran etexilate predisposes stroke disorder"" supported by the sentence: ""Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.""?",False, +13343476,Dabigatran etexilate predisposes Thromboembolism,4752,"INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.","Is the triple ""Dabigatran etexilate predisposes Thromboembolism"" supported by the sentence: ""INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.""?",False, +10867084,Ximelagatran related to atrial fibrillation,4753,Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.,"Is the triple ""Ximelagatran related to atrial fibrillation"" supported by the sentence: ""Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.""?",False, +12162541,Ximelagatran prevents thrombotic disease,4754,A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.,"Is the triple ""Ximelagatran prevents thrombotic disease"" supported by the sentence: ""A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.""?",False, +9396435,Ximelagatran prevents Thromboembolism,4755,"In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.","Is the triple ""Ximelagatran prevents Thromboembolism"" supported by the sentence: ""In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.""?",False, +13148663,Ximelagatran predisposes Thromboembolism,4756,"OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.","Is the triple ""Ximelagatran predisposes Thromboembolism"" supported by the sentence: ""OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.""?",False, +24220155,Bivalirudin related to Hemorrhage,4757,"CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.""?",False, +23845334,Bivalirudin related to thrombocytopenia,4758,"Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).","Is the triple ""Bivalirudin related to thrombocytopenia"" supported by the sentence: ""Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).""?",False, +21128552,Bivalirudin related to heart disorder,4759,"AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.","Is the triple ""Bivalirudin related to heart disorder"" supported by the sentence: ""AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.""?",False, +16166302,Bivalirudin related to coronary artery disorder,4760,Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.,"Is the triple ""Bivalirudin related to coronary artery disorder"" supported by the sentence: ""Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.""?",False, +9469606,Bivalirudin related to myocardial infarction,4761,"Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.","Is the triple ""Bivalirudin related to myocardial infarction"" supported by the sentence: ""Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.""?",False, +9060136,Bivalirudin related to acute coronary syndrome,4762,Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.,"Is the triple ""Bivalirudin related to acute coronary syndrome"" supported by the sentence: ""Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.""?",False, +21743704,Bivalirudin related to Hemorrhage,4763,"On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.""?",False, +18003165,Bivalirudin related to thrombotic disease,4764,"CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.","Is the triple ""Bivalirudin related to thrombotic disease"" supported by the sentence: ""CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.""?",False, +15575490,Bivalirudin causes myocardial infarction,4765,These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.,"Is the triple ""Bivalirudin causes myocardial infarction"" supported by the sentence: ""These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.""?",False, +10298579,Bivalirudin causes Hemorrhage,4766,"However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).","Is the triple ""Bivalirudin causes Hemorrhage"" supported by the sentence: ""However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).""?",False, +19056194,Bivalirudin affects thrombotic disease,4767,Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.""?",False, +15575489,Bivalirudin affects thrombotic disease,4768,DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).""?",False, +14748514,Bivalirudin affects myocardial infarction,4769,"Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.","Is the triple ""Bivalirudin affects myocardial infarction"" supported by the sentence: ""Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.""?",False, +14318099,Bivalirudin affects Hemorrhage,4770,Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.,"Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.""?",False, +9597163,Bivalirudin affects Hemorrhage,4771,"In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.","Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.""?",False, +19316921,Bivalirudin disrupts myocardial infarction,4772,"CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.","Is the triple ""Bivalirudin disrupts myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.""?",False, +19056195,Bivalirudin disrupts thrombotic disease,4773,"BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.","Is the triple ""Bivalirudin disrupts thrombotic disease"" supported by the sentence: ""BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.""?",False, +13525067,Bivalirudin disrupts acute coronary syndrome,4774,Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.,"Is the triple ""Bivalirudin disrupts acute coronary syndrome"" supported by the sentence: ""Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.""?",False, +13434992,Bivalirudin disrupts Hemorrhage,4775,"Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.","Is the triple ""Bivalirudin disrupts Hemorrhage"" supported by the sentence: ""Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.""?",False, +21793150,Bivalirudin prevents Hemorrhage,4776,Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.,"Is the triple ""Bivalirudin prevents Hemorrhage"" supported by the sentence: ""Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.""?",False, +20637086,Bivalirudin prevents syndromic disease,4777,Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.,"Is the triple ""Bivalirudin prevents syndromic disease"" supported by the sentence: ""Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.""?",False, +17823880,Bivalirudin prevents myocardial infarction,4778,"This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).","Is the triple ""Bivalirudin prevents myocardial infarction"" supported by the sentence: ""This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).""?",False, +10215156,Bivalirudin prevents thrombotic disease,4779,Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.,"Is the triple ""Bivalirudin prevents thrombotic disease"" supported by the sentence: ""Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.""?",False, +22425248,Bivalirudin predisposes Hemorrhage,4780,"Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.","Is the triple ""Bivalirudin predisposes Hemorrhage"" supported by the sentence: ""Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.""?",False, +16276306,Bivalirudin predisposes thrombotic disease,4781,"Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.","Is the triple ""Bivalirudin predisposes thrombotic disease"" supported by the sentence: ""Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.""?",False, +14172527,Bivalirudin predisposes myocardial infarction,4782,A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).,"Is the triple ""Bivalirudin predisposes myocardial infarction"" supported by the sentence: ""A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).""?",False, +17086386,Melagatran disrupts thrombotic disease,4783,"The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.","Is the triple ""Melagatran disrupts thrombotic disease"" supported by the sentence: ""The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.""?",False, +9182682,Lepirudin related to thrombotic disease,4784,"Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.","Is the triple ""Lepirudin related to thrombotic disease"" supported by the sentence: ""Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.""?",False, +27183131,Lepirudin affects thrombotic disease,4785,Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.,"Is the triple ""Lepirudin affects thrombotic disease"" supported by the sentence: ""Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.""?",False, +26612130,Lepirudin disrupts thrombotic disease,4786,Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.,"Is the triple ""Lepirudin disrupts thrombotic disease"" supported by the sentence: ""Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.""?",False, +9038512,Lepirudin prevents thrombotic disease,4787,"Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.","Is the triple ""Lepirudin prevents thrombotic disease"" supported by the sentence: ""Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.""?",False, +24074121,Ripasudil affects Fuchs' endothelial dystrophy,4788,"Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).","Is the triple ""Ripasudil affects Fuchs' endothelial dystrophy"" supported by the sentence: ""Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).""?",False, +23144840,Netarsudil prevents corneal edema,4789,CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.,"Is the triple ""Netarsudil prevents corneal edema"" supported by the sentence: ""CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.""?",False, +21457868,Netarsudil prevents open-angle glaucoma,4790,Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.,"Is the triple ""Netarsudil prevents open-angle glaucoma"" supported by the sentence: ""Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.""?",False, +25249408,Calcitriol related to Hypocalcemia,4791,We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.,"Is the triple ""Calcitriol related to Hypocalcemia"" supported by the sentence: ""We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.""?",False, +24424216,Calcitriol related to Crohn disease,4792,"From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].","Is the triple ""Calcitriol related to Crohn disease"" supported by the sentence: ""From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].""?",False, +23057137,Calcitriol related to acute kidney failure,4793,Production and metabolic clearance of calcitriol in acute renal failure.,"Is the triple ""Calcitriol related to acute kidney failure"" supported by the sentence: ""Production and metabolic clearance of calcitriol in acute renal failure.""?",False, +21048179,Calcitriol related to breast neoplasm,4794,"In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.","Is the triple ""Calcitriol related to breast neoplasm"" supported by the sentence: ""In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.""?",False, +18873537,Calcitriol related to diabetic kidney disease,4795,"The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.","Is the triple ""Calcitriol related to diabetic kidney disease"" supported by the sentence: ""The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.""?",False, +17759117,Calcitriol related to Sepsis,4796,Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.,"Is the triple ""Calcitriol related to Sepsis"" supported by the sentence: ""Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.""?",False, +17014883,Calcitriol related to hypoparathyroidism,4797,We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.,"Is the triple ""Calcitriol related to hypoparathyroidism"" supported by the sentence: ""We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.""?",False, +16783681,Calcitriol related to non-small cell lung carcinoma,4798,A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.,"Is the triple ""Calcitriol related to non-small cell lung carcinoma"" supported by the sentence: ""A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.""?",False, +16670490,Calcitriol related to postmenopausal osteoporosis,4799,Long-term treatment with calcitriol in postmenopausal osteoporosis.,"Is the triple ""Calcitriol related to postmenopausal osteoporosis"" supported by the sentence: ""Long-term treatment with calcitriol in postmenopausal osteoporosis.""?",False, +16084679,Calcitriol related to hypertensive disorder,4800,"AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.","Is the triple ""Calcitriol related to hypertensive disorder"" supported by the sentence: ""AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.""?",False, +15183062,Calcitriol related to type 1 diabetes mellitus,4801,OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.,"Is the triple ""Calcitriol related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.""?",False, +13574949,Calcitriol related to neoplasm,4802,"We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.","Is the triple ""Calcitriol related to neoplasm"" supported by the sentence: ""We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.""?",False, +13228040,Calcitriol related to castration-resistant prostate carcinoma,4803,"Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.","Is the triple ""Calcitriol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.""?",False, +11632117,Calcitriol related to prostate cancer,4804,Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.,"Is the triple ""Calcitriol related to prostate cancer"" supported by the sentence: ""Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.""?",False, +11549262,Calcitriol related to renal osteodystrophy,4805,"In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.","Is the triple ""Calcitriol related to renal osteodystrophy"" supported by the sentence: ""In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.""?",False, +11138207,Calcitriol related to skin basal cell carcinoma,4806,"RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.","Is the triple ""Calcitriol related to skin basal cell carcinoma"" supported by the sentence: ""RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.""?",False, +9056874,Calcitriol related to psoriasis,4807,"Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.","Is the triple ""Calcitriol related to psoriasis"" supported by the sentence: ""Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.""?",False, +8335532,Calcitriol related to chronic kidney disease,4808,This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.,"Is the triple ""Calcitriol related to chronic kidney disease"" supported by the sentence: ""This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.""?",False, +7638906,Calcitriol related to myelodysplastic syndrome,4809,Calcitriol in myelodysplastic syndromes.,"Is the triple ""Calcitriol related to myelodysplastic syndrome"" supported by the sentence: ""Calcitriol in myelodysplastic syndromes.""?",False, +7210521,Calcitriol related to osteoporosis,4810,"To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.","Is the triple ""Calcitriol related to osteoporosis"" supported by the sentence: ""To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.""?",False, +23300761,Calcitriol causes hypoparathyroidism,4811,Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.,"Is the triple ""Calcitriol causes hypoparathyroidism"" supported by the sentence: ""Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.""?",False, +22190855,Calcitriol causes Hypocalcemia,4812,"At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.","Is the triple ""Calcitriol causes Hypocalcemia"" supported by the sentence: ""At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.""?",False, +13672029,Calcitriol causes renal osteodystrophy,4813,"Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.","Is the triple ""Calcitriol causes renal osteodystrophy"" supported by the sentence: ""Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.""?",False, +8610431,Calcitriol causes neoplasm,4814,In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.,"Is the triple ""Calcitriol causes neoplasm"" supported by the sentence: ""In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.""?",False, +26699785,Calcitriol affects myelodysplastic syndrome,4815,"Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.","Is the triple ""Calcitriol affects myelodysplastic syndrome"" supported by the sentence: ""Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.""?",False, +26649101,Calcitriol affects psoriasis,4816,Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.,"Is the triple ""Calcitriol affects psoriasis"" supported by the sentence: ""Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.""?",False, +20118335,Calcitriol affects chronic kidney disease,4817,"A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.","Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.""?",False, +18144364,Calcitriol affects diabetic kidney disease,4818,CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.,"Is the triple ""Calcitriol affects diabetic kidney disease"" supported by the sentence: ""CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.""?",False, +17907580,Calcitriol affects breast neoplasm,4819,In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.,"Is the triple ""Calcitriol affects breast neoplasm"" supported by the sentence: ""In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.""?",False, +15840384,Calcitriol affects skin basal cell carcinoma,4820,Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.,"Is the triple ""Calcitriol affects skin basal cell carcinoma"" supported by the sentence: ""Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.""?",False, +15206874,Calcitriol affects neoplasm,4821,Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.""?",False, +15145405,Calcitriol affects neoplasm,4822,Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.""?",False, +10932246,Calcitriol affects chronic kidney disease,4823,Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.,"Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.""?",False, +9912093,Calcitriol affects prostate cancer,4824,Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.,"Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.""?",False, +9912091,Calcitriol affects prostate cancer,4825,"As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.","Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.""?",False, +26695789,Calcitriol produces renal osteodystrophy,4826,Renal osteodystrophy may be modulated by extrarenal production of calcitriol.,"Is the triple ""Calcitriol produces renal osteodystrophy"" supported by the sentence: ""Renal osteodystrophy may be modulated by extrarenal production of calcitriol.""?",False, +14288417,Calcitriol produces Crohn disease,4827,"Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).","Is the triple ""Calcitriol produces Crohn disease"" supported by the sentence: ""Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).""?",False, +19013737,Calcitriol disrupts chronic kidney disease,4828,"Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.","Is the triple ""Calcitriol disrupts chronic kidney disease"" supported by the sentence: ""Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.""?",False, +17492128,Calcitriol disrupts prostate cancer,4829,"Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).","Is the triple ""Calcitriol disrupts prostate cancer"" supported by the sentence: ""Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).""?",False, +15711853,Calcitriol disrupts neoplasm,4830,"Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.","Is the triple ""Calcitriol disrupts neoplasm"" supported by the sentence: ""Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.""?",False, +23005720,Calcitriol prevents neoplasm,4831,"We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.","Is the triple ""Calcitriol prevents neoplasm"" supported by the sentence: ""We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.""?",False, +22688863,Calcitriol prevents Hypocalcemia,4832,"Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.","Is the triple ""Calcitriol prevents Hypocalcemia"" supported by the sentence: ""Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.""?",False, +18398383,Calcitriol prevents diabetic kidney disease,4833,OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).,"Is the triple ""Calcitriol prevents diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).""?",False, +17492127,Calcitriol prevents prostate cancer,4834,"To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)","Is the triple ""Calcitriol prevents prostate cancer"" supported by the sentence: ""To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)""?",False, +8346486,Calcitriol prevents osteoporosis,4835,Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.,"Is the triple ""Calcitriol prevents osteoporosis"" supported by the sentence: ""Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.""?",False, +8053720,Calcitriol prevents postmenopausal osteoporosis,4836,CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.,"Is the triple ""Calcitriol prevents postmenopausal osteoporosis"" supported by the sentence: ""CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.""?",False, +24886178,Calcitriol exacerbates Sepsis,4837,"Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.","Is the triple ""Calcitriol exacerbates Sepsis"" supported by the sentence: ""Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.""?",False, +18653087,Calcitriol exacerbates hypertensive disorder,4838,"Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.","Is the triple ""Calcitriol exacerbates hypertensive disorder"" supported by the sentence: ""Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.""?",False, +21373396,Calcitriol predisposes chronic kidney disease,4839,"Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.","Is the triple ""Calcitriol predisposes chronic kidney disease"" supported by the sentence: ""Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.""?",False, +17377804,Calcitriol predisposes hypertensive disorder,4840,Calcitriol deficiency is a risk factor for DM and hypertension.,"Is the triple ""Calcitriol predisposes hypertensive disorder"" supported by the sentence: ""Calcitriol deficiency is a risk factor for DM and hypertension.""?",False, +16828204,Calcitriol predisposes osteoporosis,4841,OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.,"Is the triple ""Calcitriol predisposes osteoporosis"" supported by the sentence: ""OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.""?",False, +9760670,Calcitriol predisposes prostate cancer,4842,"Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.","Is the triple ""Calcitriol predisposes prostate cancer"" supported by the sentence: ""Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.""?",False, +26462827,Alfacalcidol related to kidney failure,4843,The use of alfacalcidol in the prevention of bone disease in early renal failure.,"Is the triple ""Alfacalcidol related to kidney failure"" supported by the sentence: ""The use of alfacalcidol in the prevention of bone disease in early renal failure.""?",False, +9037270,Alfacalcidol related to postmenopausal osteoporosis,4844,"We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.","Is the triple ""Alfacalcidol related to postmenopausal osteoporosis"" supported by the sentence: ""We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.""?",False, +7210524,Alfacalcidol related to osteoporosis,4845,"These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.","Is the triple ""Alfacalcidol related to osteoporosis"" supported by the sentence: ""These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.""?",False, +22711685,Alfacalcidol causes osteoporosis,4846,"Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.","Is the triple ""Alfacalcidol causes osteoporosis"" supported by the sentence: ""Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.""?",False, +26635675,Alfacalcidol affects kidney failure,4847,"Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.","Is the triple ""Alfacalcidol affects kidney failure"" supported by the sentence: ""Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.""?",False, +21927698,Alfacalcidol affects myopathy,4848,This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.,"Is the triple ""Alfacalcidol affects myopathy"" supported by the sentence: ""This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.""?",False, +11900508,Alfacalcidol affects postmenopausal osteoporosis,4849,"The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.","Is the triple ""Alfacalcidol affects postmenopausal osteoporosis"" supported by the sentence: ""The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.""?",False, +8505855,Alfacalcidol affects osteoporosis,4850,Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.,"Is the triple ""Alfacalcidol affects osteoporosis"" supported by the sentence: ""Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.""?",False, +20641062,Alfacalcidol disrupts osteoporosis,4851,The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.,"Is the triple ""Alfacalcidol disrupts osteoporosis"" supported by the sentence: ""The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.""?",False, +21927699,Alfacalcidol prevents myopathy,4852,Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.,"Is the triple ""Alfacalcidol prevents myopathy"" supported by the sentence: ""Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.""?",False, +7684744,Alfacalcidol prevents osteoporosis,4853,"There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.","Is the triple ""Alfacalcidol prevents osteoporosis"" supported by the sentence: ""There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.""?",False, +7684734,Alfacalcidol prevents postmenopausal osteoporosis,4854,Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.,"Is the triple ""Alfacalcidol prevents postmenopausal osteoporosis"" supported by the sentence: ""Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.""?",False, +24020567,Cholecalciferol related to male infertility,4855,Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.,"Is the triple ""Cholecalciferol related to male infertility"" supported by the sentence: ""Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.""?",False, +23185349,Cholecalciferol related to ulcerative colitis,4856,Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.,"Is the triple ""Cholecalciferol related to ulcerative colitis"" supported by the sentence: ""Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.""?",False, +22584995,Cholecalciferol related to acute myeloid leukemia,4857,"CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.","Is the triple ""Cholecalciferol related to acute myeloid leukemia"" supported by the sentence: ""CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.""?",False, +21514930,Cholecalciferol related to Infection,4858,"Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.","Is the triple ""Cholecalciferol related to Infection"" supported by the sentence: ""Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.""?",False, +21254434,Cholecalciferol related to depressive disorder,4859,"Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.","Is the triple ""Cholecalciferol related to depressive disorder"" supported by the sentence: ""Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.""?",False, +20389616,Cholecalciferol related to anemia,4860,Proportion of anemia increased by trimester among women with colecalciferol deficiency.,"Is the triple ""Cholecalciferol related to anemia"" supported by the sentence: ""Proportion of anemia increased by trimester among women with colecalciferol deficiency.""?",False, +20190699,Cholecalciferol related to autism spectrum disorder,4861,Untangling the most probable role for vitamin D3 in autism.,"Is the triple ""Cholecalciferol related to autism spectrum disorder"" supported by the sentence: ""Untangling the most probable role for vitamin D3 in autism.""?",False, +19639056,Cholecalciferol related to pulmonary tuberculosis,4862,Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.,"Is the triple ""Cholecalciferol related to pulmonary tuberculosis"" supported by the sentence: ""Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.""?",False, +18980881,Cholecalciferol related to chronic obstructive pulmonary disease,4863,"These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.","Is the triple ""Cholecalciferol related to chronic obstructive pulmonary disease"" supported by the sentence: ""These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.""?",False, +18889413,Cholecalciferol related to polycystic ovary syndrome,4864,Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?,"Is the triple ""Cholecalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?""?",False, +18830431,Cholecalciferol related to prostate cancer,4865,"Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.","Is the triple ""Cholecalciferol related to prostate cancer"" supported by the sentence: ""Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.""?",False, +18776998,Cholecalciferol related to epilepsy,4866,"These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.","Is the triple ""Cholecalciferol related to epilepsy"" supported by the sentence: ""These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.""?",False, +18009382,Cholecalciferol related to type 1 diabetes mellitus,4867,Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.,"Is the triple ""Cholecalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.""?",False, +17581366,Cholecalciferol related to vitamin D deficiency,4868,The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.,"Is the triple ""Cholecalciferol related to vitamin D deficiency"" supported by the sentence: ""The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.""?",False, +17374616,Cholecalciferol related to type 2 diabetes mellitus,4869,METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.,"Is the triple ""Cholecalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.""?",False, +17169513,Cholecalciferol related to Parkinson disease,4870,CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.,"Is the triple ""Cholecalciferol related to Parkinson disease"" supported by the sentence: ""CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.""?",False, +17054911,Cholecalciferol related to tuberculosis,4871,Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.,"Is the triple ""Cholecalciferol related to tuberculosis"" supported by the sentence: ""Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.""?",False, +16909919,Cholecalciferol related to inflammatory bowel disease,4872,Vitamin D3 has been considered a viable adjunctive therapy in IBD.,"Is the triple ""Cholecalciferol related to inflammatory bowel disease"" supported by the sentence: ""Vitamin D3 has been considered a viable adjunctive therapy in IBD.""?",False, +16219443,"Cholecalciferol related to dermatitis, atopic",4873,Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.,"Is the triple ""Cholecalciferol related to dermatitis, atopic"" supported by the sentence: ""Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.""?",False, +16115730,Cholecalciferol related to cardiovascular disorder,4874,Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.,"Is the triple ""Cholecalciferol related to cardiovascular disorder"" supported by the sentence: ""Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.""?",False, +15133291,Cholecalciferol related to Marchiafava-Bignami disease,4875,"Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.","Is the triple ""Cholecalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.""?",False, +14512631,Cholecalciferol related to hyperparathyroidism,4876,Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.,"Is the triple ""Cholecalciferol related to hyperparathyroidism"" supported by the sentence: ""Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.""?",False, +13680137,Cholecalciferol related to multiple sclerosis,4877,"Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.","Is the triple ""Cholecalciferol related to multiple sclerosis"" supported by the sentence: ""Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.""?",False, +13562951,Cholecalciferol related to metabolic syndrome X,4878,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to metabolic syndrome X"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, +13562949,Cholecalciferol related to obesity disorder,4879,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to obesity disorder"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, +13035326,Cholecalciferol related to bone fracture,4880,Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.,"Is the triple ""Cholecalciferol related to bone fracture"" supported by the sentence: ""Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.""?",False, +11935565,Cholecalciferol related to osteoporosis,4881,"The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.","Is the triple ""Cholecalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.""?",False, +11152529,Cholecalciferol related to diabetes mellitus,4882,"Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.","Is the triple ""Cholecalciferol related to diabetes mellitus"" supported by the sentence: ""Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.""?",False, +10386853,Cholecalciferol related to Crohn disease,4883,OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.,"Is the triple ""Cholecalciferol related to Crohn disease"" supported by the sentence: ""OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.""?",False, +9703967,Cholecalciferol related to melanoma,4884,"As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.","Is the triple ""Cholecalciferol related to melanoma"" supported by the sentence: ""As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.""?",False, +9414232,Cholecalciferol related to psoriasis,4885,Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.,"Is the triple ""Cholecalciferol related to psoriasis"" supported by the sentence: ""Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.""?",False, +8798994,Cholecalciferol related to hip fracture,4886,"Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.","Is the triple ""Cholecalciferol related to hip fracture"" supported by the sentence: ""Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.""?",False, +20878953,Cholecalciferol causes polycystic ovary syndrome,4887,"Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.","Is the triple ""Cholecalciferol causes polycystic ovary syndrome"" supported by the sentence: ""Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.""?",False, +20469671,Cholecalciferol causes tuberculosis,4888,Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.,"Is the triple ""Cholecalciferol causes tuberculosis"" supported by the sentence: ""Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.""?",False, +20417553,Cholecalciferol causes psoriasis,4889,There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.,"Is the triple ""Cholecalciferol causes psoriasis"" supported by the sentence: ""There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.""?",False, +19411734,"Cholecalciferol causes dermatitis, atopic",4890,"In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.","Is the triple ""Cholecalciferol causes dermatitis, atopic"" supported by the sentence: ""In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.""?",False, +17854537,Cholecalciferol causes neoplasm,4891,"Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.","Is the triple ""Cholecalciferol causes neoplasm"" supported by the sentence: ""Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.""?",False, +15944158,Cholecalciferol causes vitamin D deficiency,4892,"Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.","Is the triple ""Cholecalciferol causes vitamin D deficiency"" supported by the sentence: ""Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.""?",False, +13998286,Cholecalciferol causes depressive disorder,4893,"Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.","Is the triple ""Cholecalciferol causes depressive disorder"" supported by the sentence: ""Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.""?",False, +27560876,Cholecalciferol affects prostate cancer,4894,Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.,"Is the triple ""Cholecalciferol affects prostate cancer"" supported by the sentence: ""Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.""?",False, +22640117,Cholecalciferol affects severe acute respiratory syndrome,4895,Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?,"Is the triple ""Cholecalciferol affects severe acute respiratory syndrome"" supported by the sentence: ""Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?""?",False, +21843529,Cholecalciferol affects Pregnancy,4896,"Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.""?",False, +21703950,Cholecalciferol affects Marchiafava-Bignami disease,4897,"VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.","Is the triple ""Cholecalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.""?",False, +20945952,Cholecalciferol affects type 2 diabetes mellitus,4898,Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.,"Is the triple ""Cholecalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.""?",False, +20733345,Cholecalciferol affects epilepsy,4899,"Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.","Is the triple ""Cholecalciferol affects epilepsy"" supported by the sentence: ""Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.""?",False, +20612106,Cholecalciferol affects Cognitive impairment,4900,Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.,"Is the triple ""Cholecalciferol affects Cognitive impairment"" supported by the sentence: ""Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.""?",False, +19925618,Cholecalciferol affects asthma,4901,"METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.","Is the triple ""Cholecalciferol affects asthma"" supported by the sentence: ""METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.""?",False, +19815601,Cholecalciferol affects ulcerative colitis,4902,The effect of vitamin D3 on UC disease activity is still unclear.,"Is the triple ""Cholecalciferol affects ulcerative colitis"" supported by the sentence: ""The effect of vitamin D3 on UC disease activity is still unclear.""?",False, +19556148,Cholecalciferol affects neoplasm,4903,"In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.""?",False, +19132727,Cholecalciferol affects obesity disorder,4904,Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.,"Is the triple ""Cholecalciferol affects obesity disorder"" supported by the sentence: ""Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.""?",False, +18122364,Cholecalciferol affects metabolic syndrome X,4905,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects metabolic syndrome X"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, +18122363,Cholecalciferol affects cardiovascular disorder,4906,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects cardiovascular disorder"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, +17715748,Cholecalciferol affects hip fracture,4907,"Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.","Is the triple ""Cholecalciferol affects hip fracture"" supported by the sentence: ""Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.""?",False, +17674517,Cholecalciferol affects Pregnancy,4908,"OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.""?",False, +17585577,Cholecalciferol affects depressive disorder,4909,"It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.","Is the triple ""Cholecalciferol affects depressive disorder"" supported by the sentence: ""It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.""?",False, +17451551,Cholecalciferol affects neoplasm,4910,"Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.""?",False, +16299943,Cholecalciferol affects polycystic ovary syndrome,4911,"The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).","Is the triple ""Cholecalciferol affects polycystic ovary syndrome"" supported by the sentence: ""The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).""?",False, +16007821,Cholecalciferol affects psoriasis,4912,Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.,"Is the triple ""Cholecalciferol affects psoriasis"" supported by the sentence: ""Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.""?",False, +15977971,Cholecalciferol affects melanoma,4913,"CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.","Is the triple ""Cholecalciferol affects melanoma"" supported by the sentence: ""CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.""?",False, +15944152,Cholecalciferol affects osteoporosis,4914,[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].,"Is the triple ""Cholecalciferol affects osteoporosis"" supported by the sentence: ""[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].""?",False, +15393278,Cholecalciferol affects chronic obstructive pulmonary disease,4915,"Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.","Is the triple ""Cholecalciferol affects chronic obstructive pulmonary disease"" supported by the sentence: ""Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.""?",False, +15170889,Cholecalciferol affects multiple sclerosis,4916,The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.,"Is the triple ""Cholecalciferol affects multiple sclerosis"" supported by the sentence: ""The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.""?",False, +13518388,Cholecalciferol affects bone fracture,4917,[Latest evidence on the suppressive effect of active vitamin D3 on fractures].,"Is the triple ""Cholecalciferol affects bone fracture"" supported by the sentence: ""[Latest evidence on the suppressive effect of active vitamin D3 on fractures].""?",False, +21045274,Cholecalciferol produces Marchiafava-Bignami disease,4918,"CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.","Is the triple ""Cholecalciferol produces Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.""?",False, +17840044,Cholecalciferol produces inflammatory bowel disease,4919,"The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.","Is the triple ""Cholecalciferol produces inflammatory bowel disease"" supported by the sentence: ""The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.""?",False, +20733344,Cholecalciferol disrupts epilepsy,4920,Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.,"Is the triple ""Cholecalciferol disrupts epilepsy"" supported by the sentence: ""Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.""?",False, +19044664,Cholecalciferol disrupts AIDS,4921,Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.,"Is the triple ""Cholecalciferol disrupts AIDS"" supported by the sentence: ""Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.""?",False, +15558469,Cholecalciferol disrupts HIV infectious disease,4922,"Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.","Is the triple ""Cholecalciferol disrupts HIV infectious disease"" supported by the sentence: ""Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.""?",False, +14834931,Cholecalciferol disrupts neoplasm,4923,"Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.","Is the triple ""Cholecalciferol disrupts neoplasm"" supported by the sentence: ""Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.""?",False, +14617748,Cholecalciferol disrupts multiple sclerosis,4924,"Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.","Is the triple ""Cholecalciferol disrupts multiple sclerosis"" supported by the sentence: ""Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.""?",False, +14491908,Cholecalciferol disrupts vitamin D deficiency,4925,"Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.","Is the triple ""Cholecalciferol disrupts vitamin D deficiency"" supported by the sentence: ""Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.""?",False, +11194374,Cholecalciferol disrupts Marchiafava-Bignami disease,4926,Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.,"Is the triple ""Cholecalciferol disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.""?",False, +25419746,Cholecalciferol prevents Infection,4927,This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.,"Is the triple ""Cholecalciferol prevents Infection"" supported by the sentence: ""This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.""?",False, +23552226,Cholecalciferol prevents type 1 diabetes mellitus,4928,Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?,"Is the triple ""Cholecalciferol prevents type 1 diabetes mellitus"" supported by the sentence: ""Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?""?",False, +23324302,Cholecalciferol prevents ulcerative colitis,4929,CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.,"Is the triple ""Cholecalciferol prevents ulcerative colitis"" supported by the sentence: ""CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.""?",False, +22418643,Cholecalciferol prevents chronic obstructive pulmonary disease,4930,"MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).","Is the triple ""Cholecalciferol prevents chronic obstructive pulmonary disease"" supported by the sentence: ""MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).""?",False, +22340834,Cholecalciferol prevents depressive disorder,4931,These findings do not support the use of vitamin D3 in adults to prevent depression.,"Is the triple ""Cholecalciferol prevents depressive disorder"" supported by the sentence: ""These findings do not support the use of vitamin D3 in adults to prevent depression.""?",False, +20959064,Cholecalciferol prevents postmenopausal osteoporosis,4932,"Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?","Is the triple ""Cholecalciferol prevents postmenopausal osteoporosis"" supported by the sentence: ""Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?""?",False, +20699168,Cholecalciferol prevents cardiovascular disorder,4933,"Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.","Is the triple ""Cholecalciferol prevents cardiovascular disorder"" supported by the sentence: ""Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.""?",False, +19389521,Cholecalciferol prevents epilepsy,4934,"Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.","Is the triple ""Cholecalciferol prevents epilepsy"" supported by the sentence: ""Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.""?",False, +18282049,Cholecalciferol prevents inherited lipid metabolism disorder,4935,"Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.","Is the triple ""Cholecalciferol prevents inherited lipid metabolism disorder"" supported by the sentence: ""Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.""?",False, +17951280,Cholecalciferol prevents anemia,4936,VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.,"Is the triple ""Cholecalciferol prevents anemia"" supported by the sentence: ""VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.""?",False, +17701830,Cholecalciferol prevents influenza,4937,[Does vitamin D3 fail to protect against influenza after all?].,"Is the triple ""Cholecalciferol prevents influenza"" supported by the sentence: ""[Does vitamin D3 fail to protect against influenza after all?].""?",False, +15773595,Cholecalciferol prevents neoplasm,4938,[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].,"Is the triple ""Cholecalciferol prevents neoplasm"" supported by the sentence: ""[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].""?",False, +15663430,Cholecalciferol prevents diabetes mellitus,4939,"There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.","Is the triple ""Cholecalciferol prevents diabetes mellitus"" supported by the sentence: ""There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.""?",False, +12943427,Cholecalciferol prevents vitamin D deficiency,4940,"The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.","Is the triple ""Cholecalciferol prevents vitamin D deficiency"" supported by the sentence: ""The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.""?",False, +11194373,Cholecalciferol prevents osteoporosis,4941,"The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.","Is the triple ""Cholecalciferol prevents osteoporosis"" supported by the sentence: ""The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.""?",False, +11017561,Cholecalciferol prevents Marchiafava-Bignami disease,4942,Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.,"Is the triple ""Cholecalciferol prevents Marchiafava-Bignami disease"" supported by the sentence: ""Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.""?",False, +10503621,Cholecalciferol prevents bone fracture,4943,CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.,"Is the triple ""Cholecalciferol prevents bone fracture"" supported by the sentence: ""CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.""?",False, +9458588,Cholecalciferol prevents hip fracture,4944,We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.,"Is the triple ""Cholecalciferol prevents hip fracture"" supported by the sentence: ""We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.""?",False, +21072124,Cholecalciferol predisposes metabolic syndrome X,4945,"Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.","Is the triple ""Cholecalciferol predisposes metabolic syndrome X"" supported by the sentence: ""Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.""?",False, +18104348,Cholecalciferol predisposes colorectal neoplasm,4946,These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.,"Is the triple ""Cholecalciferol predisposes colorectal neoplasm"" supported by the sentence: ""These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.""?",False, +17901013,Cholecalciferol predisposes bone fracture,4947,"Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.","Is the triple ""Cholecalciferol predisposes bone fracture"" supported by the sentence: ""Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.""?",False, +17714481,Cholecalciferol predisposes asthma,4948,"Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.","Is the triple ""Cholecalciferol predisposes asthma"" supported by the sentence: ""Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.""?",False, +17184810,Cholecalciferol predisposes multiple sclerosis,4949,"There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.","Is the triple ""Cholecalciferol predisposes multiple sclerosis"" supported by the sentence: ""There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.""?",False, +15110409,Cholecalciferol predisposes vitamin D deficiency,4950,Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.,"Is the triple ""Cholecalciferol predisposes vitamin D deficiency"" supported by the sentence: ""Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.""?",False, +13562954,Cholecalciferol predisposes type 2 diabetes mellitus,4951,"In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.","Is the triple ""Cholecalciferol predisposes type 2 diabetes mellitus"" supported by the sentence: ""In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.""?",False, +9524358,Cholecalciferol predisposes hip fracture,4952,"Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.","Is the triple ""Cholecalciferol predisposes hip fracture"" supported by the sentence: ""Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.""?",False, +9314384,Cholecalciferol predisposes Marchiafava-Bignami disease,4953,"Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.","Is the triple ""Cholecalciferol predisposes Marchiafava-Bignami disease"" supported by the sentence: ""Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.""?",False, +27330803,Ergocalciferol related to Familial hypophosphatemia,4954,Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.,"Is the triple ""Ergocalciferol related to Familial hypophosphatemia"" supported by the sentence: ""Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.""?",False, +26089502,Ergocalciferol related to osteogenesis imperfecta,4955,Vitamin D and related research in osteogenesis imperfecta.,"Is the triple ""Ergocalciferol related to osteogenesis imperfecta"" supported by the sentence: ""Vitamin D and related research in osteogenesis imperfecta.""?",False, +22199149,Ergocalciferol related to Hypocalcemia,4956,Hypocalcemia may be associated with imbalanced VD and PTH levels.,"Is the triple ""Ergocalciferol related to Hypocalcemia"" supported by the sentence: ""Hypocalcemia may be associated with imbalanced VD and PTH levels.""?",False, +22194600,Ergocalciferol related to severe acute respiratory syndrome,4957,"Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.","Is the triple ""Ergocalciferol related to severe acute respiratory syndrome"" supported by the sentence: ""Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.""?",False, +21840711,Ergocalciferol related to castration-resistant prostate carcinoma,4958,"Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.","Is the triple ""Ergocalciferol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.""?",False, +21543726,Ergocalciferol related to sarcopenia,4959,"Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.","Is the triple ""Ergocalciferol related to sarcopenia"" supported by the sentence: ""Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.""?",False, +21516783,Ergocalciferol related to non-alcoholic fatty liver disease,4960,"Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.","Is the triple ""Ergocalciferol related to non-alcoholic fatty liver disease"" supported by the sentence: ""Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.""?",False, +21478252,Ergocalciferol related to bone fracture,4961,"Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.","Is the triple ""Ergocalciferol related to bone fracture"" supported by the sentence: ""Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.""?",False, +21128214,Ergocalciferol related to bone Paget disease,4962,Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.,"Is the triple ""Ergocalciferol related to bone Paget disease"" supported by the sentence: ""Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.""?",False, +20256197,Ergocalciferol related to restless legs syndrome,4963,"After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).","Is the triple ""Ergocalciferol related to restless legs syndrome"" supported by the sentence: ""After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).""?",False, +19853448,Ergocalciferol related to neuralgia,4964,This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.,"Is the triple ""Ergocalciferol related to neuralgia"" supported by the sentence: ""This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.""?",False, +19595978,Ergocalciferol related to hepatitis C virus infection,4965,BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.,"Is the triple ""Ergocalciferol related to hepatitis C virus infection"" supported by the sentence: ""BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.""?",False, +19221334,Ergocalciferol related to spinal cord injury,4966,"Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.","Is the triple ""Ergocalciferol related to spinal cord injury"" supported by the sentence: ""Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.""?",False, +18303138,Ergocalciferol related to optic neuritis,4967,"The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.","Is the triple ""Ergocalciferol related to optic neuritis"" supported by the sentence: ""The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.""?",False, +17457750,Ergocalciferol related to migraine disorder,4968,"CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.","Is the triple ""Ergocalciferol related to migraine disorder"" supported by the sentence: ""CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.""?",False, +17248671,Ergocalciferol related to diffuse alopecia areata,4969,"There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.","Is the triple ""Ergocalciferol related to diffuse alopecia areata"" supported by the sentence: ""There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.""?",False, +16231683,Ergocalciferol related to chronic hepatitis C virus infection,4970,Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.,"Is the triple ""Ergocalciferol related to chronic hepatitis C virus infection"" supported by the sentence: ""Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.""?",False, +16050991,Ergocalciferol related to lung neoplasm,4971,"In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.","Is the triple ""Ergocalciferol related to lung neoplasm"" supported by the sentence: ""In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.""?",False, +15954794,Ergocalciferol related to femoral neck fracture,4972,Spontaneous femoral neck fracture associated with a low serum level of vitamin D.,"Is the triple ""Ergocalciferol related to femoral neck fracture"" supported by the sentence: ""Spontaneous femoral neck fracture associated with a low serum level of vitamin D.""?",False, +15739454,Ergocalciferol related to diabetic neuropathy,4973,Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.,"Is the triple ""Ergocalciferol related to diabetic neuropathy"" supported by the sentence: ""Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.""?",False, +15603622,Ergocalciferol related to HIV infectious disease,4974,Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.,"Is the triple ""Ergocalciferol related to HIV infectious disease"" supported by the sentence: ""Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.""?",False, +15306422,Ergocalciferol related to blood coagulation disease,4975,"Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.","Is the triple ""Ergocalciferol related to blood coagulation disease"" supported by the sentence: ""Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.""?",False, +15165807,Ergocalciferol related to postmenopausal osteoporosis,4976,Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.,"Is the triple ""Ergocalciferol related to postmenopausal osteoporosis"" supported by the sentence: ""Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.""?",False, +14949967,Ergocalciferol related to Premature birth,4977,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to Premature birth"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, +14949966,Ergocalciferol related to gestational diabetes,4978,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to gestational diabetes"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, +14870236,Ergocalciferol related to chronic renal failure syndrome,4979,[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].,"Is the triple ""Ergocalciferol related to chronic renal failure syndrome"" supported by the sentence: ""[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].""?",False, +14594285,Ergocalciferol related to colorectal neoplasm,4980,"Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.","Is the triple ""Ergocalciferol related to colorectal neoplasm"" supported by the sentence: ""Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.""?",False, +14321159,Ergocalciferol related to asthma,4981,"Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.","Is the triple ""Ergocalciferol related to asthma"" supported by the sentence: ""Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.""?",False, +13975664,Ergocalciferol related to cutaneous lupus erythematosus,4982,Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.,"Is the triple ""Ergocalciferol related to cutaneous lupus erythematosus"" supported by the sentence: ""Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.""?",False, +13939480,Ergocalciferol related to mood disorder,4983,This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.,"Is the triple ""Ergocalciferol related to mood disorder"" supported by the sentence: ""This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.""?",False, +13895667,Ergocalciferol related to sudden cardiac arrest,4984,OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).,"Is the triple ""Ergocalciferol related to sudden cardiac arrest"" supported by the sentence: ""OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).""?",False, +13383363,Ergocalciferol related to sickle cell anemia,4985,The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.,"Is the triple ""Ergocalciferol related to sickle cell anemia"" supported by the sentence: ""The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.""?",False, +13199782,Ergocalciferol related to Alzheimer disease,4986,"Consequently, this study provides evidence for a possible link between AD and vitamin D.","Is the triple ""Ergocalciferol related to Alzheimer disease"" supported by the sentence: ""Consequently, this study provides evidence for a possible link between AD and vitamin D.""?",False, +12834035,Ergocalciferol related to inflammatory bowel disease,4987,Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.,"Is the triple ""Ergocalciferol related to inflammatory bowel disease"" supported by the sentence: ""Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.""?",False, +12803681,Ergocalciferol related to Insulin resistance,4988,We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.,"Is the triple ""Ergocalciferol related to Insulin resistance"" supported by the sentence: ""We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.""?",False, +12377378,Ergocalciferol related to non-Hodgkin lymphoma,4989,CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.,"Is the triple ""Ergocalciferol related to non-Hodgkin lymphoma"" supported by the sentence: ""CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.""?",False, +12131992,Ergocalciferol related to primary hyperparathyroidism,4990,"Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.","Is the triple ""Ergocalciferol related to primary hyperparathyroidism"" supported by the sentence: ""Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.""?",False, +11979233,Ergocalciferol related to leukemia,4991,Vitamin D compounds in leukemia.,"Is the triple ""Ergocalciferol related to leukemia"" supported by the sentence: ""Vitamin D compounds in leukemia.""?",False, +11933002,Ergocalciferol related to Pain,4992,"CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.","Is the triple ""Ergocalciferol related to Pain"" supported by the sentence: ""CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.""?",False, +11653558,Ergocalciferol related to melanoma,4993,The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.,"Is the triple ""Ergocalciferol related to melanoma"" supported by the sentence: ""The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.""?",False, +11434397,Ergocalciferol related to type 1 diabetes mellitus,4994,"Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.","Is the triple ""Ergocalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.""?",False, +11002964,Ergocalciferol related to pulmonary tuberculosis,4995,[Effect of vitamin D2 in pulmonary tuberculosis].,"Is the triple ""Ergocalciferol related to pulmonary tuberculosis"" supported by the sentence: ""[Effect of vitamin D2 in pulmonary tuberculosis].""?",False, +10894479,Ergocalciferol related to Crohn disease,4996,"A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.","Is the triple ""Ergocalciferol related to Crohn disease"" supported by the sentence: ""A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.""?",False, +10768947,Ergocalciferol related to hip fracture,4997,BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.,"Is the triple ""Ergocalciferol related to hip fracture"" supported by the sentence: ""BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.""?",False, +10183383,Ergocalciferol related to Marchiafava-Bignami disease,4998,"Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.","Is the triple ""Ergocalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.""?",False, +10168534,Ergocalciferol related to tuberculosis,4999,"Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.","Is the triple ""Ergocalciferol related to tuberculosis"" supported by the sentence: ""Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.""?",False, +10066878,Ergocalciferol related to lymphoma,5000,"However, the cellular source of the vitamin D hormone in lymphomas remains unclear.","Is the triple ""Ergocalciferol related to lymphoma"" supported by the sentence: ""However, the cellular source of the vitamin D hormone in lymphomas remains unclear.""?",False, +9770434,Ergocalciferol related to neoplasm,1,"On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.","Is the triple ""Ergocalciferol related to neoplasm"" supported by the sentence: ""On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.""?",False, +9499640,Ergocalciferol related to hypoparathyroidism,2,The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.,"Is the triple ""Ergocalciferol related to hypoparathyroidism"" supported by the sentence: ""The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.""?",False, +9487308,Ergocalciferol related to myocardial ischemia,3,Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).,"Is the triple ""Ergocalciferol related to myocardial ischemia"" supported by the sentence: ""Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).""?",False, +9462983,Ergocalciferol related to ulcerative colitis,4,Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.,"Is the triple ""Ergocalciferol related to ulcerative colitis"" supported by the sentence: ""Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.""?",False, +9176947,Ergocalciferol related to psoriasis,5,[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].,"Is the triple ""Ergocalciferol related to psoriasis"" supported by the sentence: ""[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].""?",False, +9137351,Ergocalciferol related to nutritional disorder,6,"RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.","Is the triple ""Ergocalciferol related to nutritional disorder"" supported by the sentence: ""RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.""?",False, +8792180,Ergocalciferol related to type 2 diabetes mellitus,7,Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.,"Is the triple ""Ergocalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.""?",False, +8116213,Ergocalciferol related to obesity disorder,8,These data suggest that low vitamin D may be associated with obesity per se.,"Is the triple ""Ergocalciferol related to obesity disorder"" supported by the sentence: ""These data suggest that low vitamin D may be associated with obesity per se.""?",False, +8093753,Ergocalciferol related to vitamin D deficiency,9,The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.,"Is the triple ""Ergocalciferol related to vitamin D deficiency"" supported by the sentence: ""The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.""?",False, +8061037,Ergocalciferol related to multiple sclerosis,10,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to multiple sclerosis"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, +8061036,Ergocalciferol related to diabetes mellitus,11,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to diabetes mellitus"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, +7613246,Ergocalciferol related to osteoporosis,12,The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.,"Is the triple ""Ergocalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.""?",False, +7587226,Ergocalciferol related to polycystic ovary syndrome,13,Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.,"Is the triple ""Ergocalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.""?",False, +7252642,Ergocalciferol related to prostate cancer,14,"Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.","Is the triple ""Ergocalciferol related to prostate cancer"" supported by the sentence: ""Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.""?",False, +26403196,Ergocalciferol causes primary hyperparathyroidism,15,Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.,"Is the triple ""Ergocalciferol causes primary hyperparathyroidism"" supported by the sentence: ""Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.""?",False, +25624374,Ergocalciferol causes leukemia,16,Reversibility of vitamin D-induced human leukemia cell-line maturation.,"Is the triple ""Ergocalciferol causes leukemia"" supported by the sentence: ""Reversibility of vitamin D-induced human leukemia cell-line maturation.""?",False, +25513025,Ergocalciferol causes restless legs syndrome,17,We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.,"Is the triple ""Ergocalciferol causes restless legs syndrome"" supported by the sentence: ""We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.""?",False, +25147512,Ergocalciferol causes sarcopenia,18,"To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.","Is the triple ""Ergocalciferol causes sarcopenia"" supported by the sentence: ""To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.""?",False, +21420546,Ergocalciferol causes diabetic neuropathy,19,"Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).","Is the triple ""Ergocalciferol causes diabetic neuropathy"" supported by the sentence: ""Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).""?",False, +21344725,Ergocalciferol causes diffuse alopecia areata,20,"This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.","Is the triple ""Ergocalciferol causes diffuse alopecia areata"" supported by the sentence: ""This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.""?",False, +19221130,Ergocalciferol causes non-alcoholic fatty liver disease,21,"Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.","Is the triple ""Ergocalciferol causes non-alcoholic fatty liver disease"" supported by the sentence: ""Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.""?",False, +19022139,Ergocalciferol causes gestational diabetes,22,BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).,"Is the triple ""Ergocalciferol causes gestational diabetes"" supported by the sentence: ""BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).""?",False, +18967408,Ergocalciferol causes polycystic ovary syndrome,23,"BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.","Is the triple ""Ergocalciferol causes polycystic ovary syndrome"" supported by the sentence: ""BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.""?",False, +18875338,Ergocalciferol causes psoriasis,24,"The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.","Is the triple ""Ergocalciferol causes psoriasis"" supported by the sentence: ""The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.""?",False, +18041148,Ergocalciferol causes Crohn disease,25,"Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.","Is the triple ""Ergocalciferol causes Crohn disease"" supported by the sentence: ""Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.""?",False, +16369420,Ergocalciferol causes neoplasm,26,"Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.","Is the triple ""Ergocalciferol causes neoplasm"" supported by the sentence: ""Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.""?",False, +16017645,Ergocalciferol causes obesity disorder,27,This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.,"Is the triple ""Ergocalciferol causes obesity disorder"" supported by the sentence: ""This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.""?",False, +15862130,Ergocalciferol causes type 2 diabetes mellitus,28,"CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.","Is the triple ""Ergocalciferol causes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.""?",False, +15179909,Ergocalciferol causes asthma,29,"OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.","Is the triple ""Ergocalciferol causes asthma"" supported by the sentence: ""OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.""?",False, +14594790,Ergocalciferol causes Insulin resistance,30,"In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.","Is the triple ""Ergocalciferol causes Insulin resistance"" supported by the sentence: ""In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.""?",False, +14004176,Ergocalciferol causes Pain,31,The independent role of vitamin D in the etiology of pain remains controversial.,"Is the triple ""Ergocalciferol causes Pain"" supported by the sentence: ""The independent role of vitamin D in the etiology of pain remains controversial.""?",False, +12191251,Ergocalciferol causes osteoporosis,32,"We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.","Is the triple ""Ergocalciferol causes osteoporosis"" supported by the sentence: ""We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.""?",False, +11612180,Ergocalciferol causes colorectal neoplasm,33,There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.,"Is the triple ""Ergocalciferol causes colorectal neoplasm"" supported by the sentence: ""There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.""?",False, +11557471,Ergocalciferol causes vitamin D deficiency,34,"Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).","Is the triple ""Ergocalciferol causes vitamin D deficiency"" supported by the sentence: ""Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).""?",False, +11557464,Ergocalciferol causes inflammatory bowel disease,35,Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.,"Is the triple ""Ergocalciferol causes inflammatory bowel disease"" supported by the sentence: ""Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.""?",False, +11275618,Ergocalciferol causes type 1 diabetes mellitus,36,These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol causes type 1 diabetes mellitus"" supported by the sentence: ""These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.""?",False, +10362733,Ergocalciferol causes multiple sclerosis,37,Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.,"Is the triple ""Ergocalciferol causes multiple sclerosis"" supported by the sentence: ""Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.""?",False, +8719466,Ergocalciferol causes diabetes mellitus,38,"In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).","Is the triple ""Ergocalciferol causes diabetes mellitus"" supported by the sentence: ""In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).""?",False, +8407906,Ergocalciferol causes Marchiafava-Bignami disease,39,Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.,"Is the triple ""Ergocalciferol causes Marchiafava-Bignami disease"" supported by the sentence: ""Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.""?",False, +7553325,Ergocalciferol causes prostate cancer,40,"OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).","Is the triple ""Ergocalciferol causes prostate cancer"" supported by the sentence: ""OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).""?",False, +7357695,Ergocalciferol causes bone fracture,41,Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.,"Is the triple ""Ergocalciferol causes bone fracture"" supported by the sentence: ""Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.""?",False, +25936029,Ergocalciferol affects nutritional disorder,42,"Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.","Is the triple ""Ergocalciferol affects nutritional disorder"" supported by the sentence: ""Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.""?",False, +25430100,Ergocalciferol affects primary hyperparathyroidism,43,Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.""?",False, +24682916,Ergocalciferol affects bone fracture,44,"Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.""?",False, +24133915,Ergocalciferol affects HIV infectious disease,45,Potential immune modulatory effect of vitamin D in HIV infection: A review.,"Is the triple ""Ergocalciferol affects HIV infectious disease"" supported by the sentence: ""Potential immune modulatory effect of vitamin D in HIV infection: A review.""?",False, +23716846,Ergocalciferol affects Premature birth,46,Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.""?",False, +22436428,Ergocalciferol affects obesity disorder,47,Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).,"Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).""?",False, +22382447,Ergocalciferol affects Pregnancy,48,Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.""?",False, +21132793,Ergocalciferol affects breast neoplasm,49,"As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.","Is the triple ""Ergocalciferol affects breast neoplasm"" supported by the sentence: ""As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.""?",False, +20959246,Ergocalciferol affects diabetes mellitus,50,These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.,"Is the triple ""Ergocalciferol affects diabetes mellitus"" supported by the sentence: ""These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.""?",False, +20298561,Ergocalciferol affects inflammatory bowel disease,51,"We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.","Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.""?",False, +20058982,Ergocalciferol affects gestational diabetes,52,TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.""?",False, +19907316,Ergocalciferol affects gestational diabetes,53,This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.""?",False, +19815602,Ergocalciferol affects ulcerative colitis,54,Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.,"Is the triple ""Ergocalciferol affects ulcerative colitis"" supported by the sentence: ""Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.""?",False, +19320344,Ergocalciferol affects Premature birth,55,We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.""?",False, +19221129,Ergocalciferol affects non-alcoholic fatty liver disease,56,"Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.","Is the triple ""Ergocalciferol affects non-alcoholic fatty liver disease"" supported by the sentence: ""Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.""?",False, +18424308,Ergocalciferol affects vitamin D deficiency,57,Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.,"Is the triple ""Ergocalciferol affects vitamin D deficiency"" supported by the sentence: ""Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.""?",False, +18115621,Ergocalciferol affects asthma,58,"BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.""?",False, +17654393,Ergocalciferol affects optic neuritis,59,"CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.","Is the triple ""Ergocalciferol affects optic neuritis"" supported by the sentence: ""CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.""?",False, +17646826,Ergocalciferol affects migraine disorder,60,"However, the data examining the relation of vitamin D with migraine are limited.","Is the triple ""Ergocalciferol affects migraine disorder"" supported by the sentence: ""However, the data examining the relation of vitamin D with migraine are limited.""?",False, +17581908,Ergocalciferol affects Pain,61,Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.,"Is the triple ""Ergocalciferol affects Pain"" supported by the sentence: ""Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.""?",False, +17056932,Ergocalciferol affects sarcopenia,62,"Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.""?",False, +16630786,Ergocalciferol affects sarcopenia,63,"Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.""?",False, +16542255,Ergocalciferol affects melanoma,64,"Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.","Is the triple ""Ergocalciferol affects melanoma"" supported by the sentence: ""Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.""?",False, +16343274,Ergocalciferol affects restless legs syndrome,65,"Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.","Is the triple ""Ergocalciferol affects restless legs syndrome"" supported by the sentence: ""Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.""?",False, +16273798,Ergocalciferol affects Insulin resistance,66,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, +16273796,Ergocalciferol affects type 2 diabetes mellitus,67,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, +15812657,Ergocalciferol affects prostate cancer,68,Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.""?",False, +15750325,Ergocalciferol affects polycystic ovary syndrome,69,"Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.","Is the triple ""Ergocalciferol affects polycystic ovary syndrome"" supported by the sentence: ""Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.""?",False, +15694248,Ergocalciferol affects mood disorder,70,"BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.","Is the triple ""Ergocalciferol affects mood disorder"" supported by the sentence: ""BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.""?",False, +15543952,Ergocalciferol affects osteoporosis,71,"Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.","Is the triple ""Ergocalciferol affects osteoporosis"" supported by the sentence: ""Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.""?",False, +15528071,Ergocalciferol affects Alzheimer disease,72,These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.,"Is the triple ""Ergocalciferol affects Alzheimer disease"" supported by the sentence: ""These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.""?",False, +15258155,Ergocalciferol affects obesity disorder,73,"Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.","Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.""?",False, +14609756,Ergocalciferol affects tuberculosis,74,Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.,"Is the triple ""Ergocalciferol affects tuberculosis"" supported by the sentence: ""Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.""?",False, +14384550,Ergocalciferol affects psoriasis,75,"CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.","Is the triple ""Ergocalciferol affects psoriasis"" supported by the sentence: ""CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.""?",False, +14233188,Ergocalciferol affects Insulin resistance,76,The possible correlations of the calciotropic hormones with insulin resistance were also examined.,"Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""The possible correlations of the calciotropic hormones with insulin resistance were also examined.""?",False, +13916047,Ergocalciferol affects hip fracture,77,"RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).""?",False, +13794313,Ergocalciferol affects multiple sclerosis,78,"Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.""?",False, +13764162,Ergocalciferol affects type 2 diabetes mellitus,79,The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.,"Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.""?",False, +13437693,Ergocalciferol affects Crohn disease,80,These findings suggest that vitD may play a therapeutic role in CD.,"Is the triple ""Ergocalciferol affects Crohn disease"" supported by the sentence: ""These findings suggest that vitD may play a therapeutic role in CD.""?",False, +13211992,Ergocalciferol affects type 1 diabetes mellitus,81,BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.""?",False, +13015298,Ergocalciferol affects asthma,82,"Although vitamin D has important immunologic effects, its relation with asthma is unknown.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""Although vitamin D has important immunologic effects, its relation with asthma is unknown.""?",False, +12698804,Ergocalciferol affects chronic renal failure syndrome,83,[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].,"Is the triple ""Ergocalciferol affects chronic renal failure syndrome"" supported by the sentence: ""[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].""?",False, +12502345,Ergocalciferol affects inflammatory bowel disease,84,This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.,"Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.""?",False, +12032067,Ergocalciferol affects multiple sclerosis,85,"If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.""?",False, +11831475,Ergocalciferol affects bone fracture,86,"BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.""?",False, +10991167,Ergocalciferol affects type 1 diabetes mellitus,87,CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.""?",False, +10917919,Ergocalciferol affects primary hyperparathyroidism,88,Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.""?",False, +10608353,Ergocalciferol affects Pregnancy,89,Effect of overdose of vitamin D2 on pregnancy in the rat.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Effect of overdose of vitamin D2 on pregnancy in the rat.""?",False, +8987937,Ergocalciferol affects hip fracture,90,"To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.""?",False, +8925552,Ergocalciferol affects prostate cancer,91,Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.""?",False, +8894668,Ergocalciferol affects Marchiafava-Bignami disease,92,"However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.","Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.""?",False, +8321224,Ergocalciferol affects neoplasm,93,Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.,"Is the triple ""Ergocalciferol affects neoplasm"" supported by the sentence: ""Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.""?",False, +7878820,Ergocalciferol affects Marchiafava-Bignami disease,94,High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.,"Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.""?",False, +21952380,Ergocalciferol produces obesity disorder,95,"Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.","Is the triple ""Ergocalciferol produces obesity disorder"" supported by the sentence: ""Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.""?",False, +21636964,Ergocalciferol produces asthma,96,"Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.","Is the triple ""Ergocalciferol produces asthma"" supported by the sentence: ""Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.""?",False, +20636497,Ergocalciferol produces Pregnancy,97,"Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.","Is the triple ""Ergocalciferol produces Pregnancy"" supported by the sentence: ""Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.""?",False, +20444810,Ergocalciferol produces Alzheimer disease,98,"Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.","Is the triple ""Ergocalciferol produces Alzheimer disease"" supported by the sentence: ""Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.""?",False, +15318015,Ergocalciferol produces melanoma,99,"Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.","Is the triple ""Ergocalciferol produces melanoma"" supported by the sentence: ""Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.""?",False, +14384547,Ergocalciferol produces psoriasis,100,"Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.","Is the triple ""Ergocalciferol produces psoriasis"" supported by the sentence: ""Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.""?",False, \ No newline at end of file diff --git a/data/true_false_chembl_labeled_triple.csv b/data/true_false_chembl_labeled_triple.csv index 52ea879..64fc74f 100644 --- a/data/true_false_chembl_labeled_triple.csv +++ b/data/true_false_chembl_labeled_triple.csv @@ -5398,4603 +5398,4603 @@ 24691450,498,,related to,,Methylprednisolone,,,,plantar fasciitis,,,,, 24586108,499,,related to,,Methylprednisolone,,,,alcoholic hepatitis,,,,, 24559507,500,,related to,,Methylprednisolone,,,,respiratory system disorder,,,,, -23573980,1,,related to,,Methylprednisolone,,,,pneumonia,,,,, -23514846,2,,related to,,Methylprednisolone,,,,carpal tunnel syndrome,,,,, -23364897,3,,related to,,Methylprednisolone,,,,West syndrome,,,,, -22495910,4,,related to,,Methylprednisolone,,,,myocarditis,,,,, -22175056,5,,related to,,Methylprednisolone,,,,myopathy,,,,, -20879022,6,,related to,,Methylprednisolone,,,,Pain,,,,, -20342058,7,,related to,,Methylprednisolone,,,,chronic progressive multiple sclerosis,,,,, -20290784,8,,related to,,Methylprednisolone,,,,membranous glomerulonephritis,,,,, -20286711,9,,related to,,Methylprednisolone,,,,neuromyelitis optica,,,,, -19340184,10,,related to,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, -18938435,11,,related to,,Methylprednisolone,,,,graft versus host disease,,,,, -17333962,12,,related to,,Methylprednisolone,,,,Inflammation,,,,, -17288506,13,,related to,,Methylprednisolone,,,,autoimmune thrombocytopenic purpura,,,,, -15936572,14,,related to,,Methylprednisolone,,,,endocrine exophthalmos,,,,, -15072844,15,,related to,,Methylprednisolone,,,,Edema,,,,, -14876749,16,,related to,,Methylprednisolone,,,,osteoarthritis,,,,, -14399082,17,,related to,,Methylprednisolone,,,,aplastic anemia,,,,, -14398237,18,,related to,,Methylprednisolone,,,,IgA glomerulonephritis,,,,, -14278238,19,,related to,,Methylprednisolone,,,,"dermatitis, atopic",,,,, -14166179,20,,related to,,Methylprednisolone,,,,cardiac arrest,,,,, -12755316,21,,related to,,Methylprednisolone,,,,plasma cell myeloma,,,,, -12183687,22,,related to,,Methylprednisolone,,,,acute lymphoblastic leukemia,,,,, -11720471,23,,related to,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, -10812685,24,,related to,,Methylprednisolone,,,,immunoglobulin a vasculitis,,,,, -10763477,25,,related to,,Methylprednisolone,,,,ulcerative colitis,,,,, -10558884,26,,related to,,Methylprednisolone,,,,lupus nephritis,,,,, -10130342,27,,related to,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, -9229208,28,,related to,,Methylprednisolone,,,,vestibular neuronitis,,,,, -9003326,29,,related to,,Methylprednisolone,,,,systemic sclerosis,,,,, -8447481,30,,related to,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -8282330,31,,related to,,Methylprednisolone,,,,spinal cord injury,,,,, -7944646,32,,related to,,Methylprednisolone,,,,myasthenia gravis,,,,, -7668599,33,,related to,,Methylprednisolone,,,,multiple sclerosis,,,,, -7443745,34,,related to,,Methylprednisolone,,,,asthma,,,,, -24973247,35,,causes,,Methylprednisolone,,,,lupus nephritis,,,,, -24161886,36,,causes,,Methylprednisolone,,,,Edema,,,,, -18534953,37,,causes,,Methylprednisolone,,,,Inflammation,,,,, -18260665,38,,causes,,Methylprednisolone,,,,neoplasm,,,,, -17307095,39,,causes,,Methylprednisolone,,,,pneumonia,,,,, -15906641,40,,causes,,Methylprednisolone,,,,Pain,,,,, -13166073,41,,causes,,Methylprednisolone,,,,thrombocytopenia,,,,, -12672767,42,,causes,,Methylprednisolone,,,,drug-induced liver injury,,,,, -8525599,43,,causes,,Methylprednisolone,,,,myopathy,,,,, -27357949,44,,affects,,Methylprednisolone,,,,neoplasm,,,,, -24420470,45,,affects,,Methylprednisolone,,,,Inflammation,,,,, -23472756,46,,affects,,Methylprednisolone,,,,Inflammation,,,,, -20530617,47,,affects,,Methylprednisolone,,,,systemic sclerosis,,,,, -20254789,48,,affects,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, -17649050,49,,affects,,Methylprednisolone,,,,optic nerve disorder,,,,, -16634377,50,,affects,,Methylprednisolone,,,,myasthenia gravis,,,,, -16277488,51,,affects,,Methylprednisolone,,,,neuromyelitis optica,,,,, -15906642,52,,affects,,Methylprednisolone,,,,Pain,,,,, -15610554,53,,affects,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -15186368,54,,affects,,Methylprednisolone,,,,graft versus host disease,,,,, -14891106,55,,affects,,Methylprednisolone,,,,kidney disorder,,,,, -11819955,56,,affects,,Methylprednisolone,,,,spinal cord injury,,,,, -10845505,57,,affects,,Methylprednisolone,,,,Pain,,,,, -10048898,58,,affects,,Methylprednisolone,,,,ulcerative colitis,,,,, -9646753,59,,affects,,Methylprednisolone,,,,multiple sclerosis,,,,, -9346353,60,,affects,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, -9107378,61,,affects,,Methylprednisolone,,,,Edema,,,,, -8596544,62,,affects,,Methylprednisolone,,,,asthma,,,,, -8330909,63,,affects,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, -19744632,64,,disrupts,,Methylprednisolone,,,,Edema,,,,, -18407557,65,,disrupts,,Methylprednisolone,,,,thrombocytopenia,,,,, -11106658,66,,disrupts,,Methylprednisolone,,,,Pain,,,,, -8640603,67,,disrupts,,Methylprednisolone,,,,Inflammation,,,,, -23934495,68,,prevents,,Methylprednisolone,,,,Cognitive impairment,,,,, -20014108,69,,prevents,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -18266414,70,,prevents,,Methylprednisolone,,,,Abdominal pain,,,,, -14967074,71,,prevents,,Methylprednisolone,,,,asthma,,,,, -9744990,72,,prevents,,Methylprednisolone,,,,ovarian hyperstimulation syndrome,,,,, -8345063,73,,prevents,,Methylprednisolone,,,,Pain,,,,, -8291272,74,,prevents,,Methylprednisolone,,,,graft versus host disease,,,,, -7980138,75,,prevents,,Methylprednisolone,,,,spinal cord injury,,,,, -7414405,76,,prevents,,Methylprednisolone,,,,Edema,,,,, -18106042,77,,predisposes,,Methylprednisolone,,,,pneumonia,,,,, -9645180,78,,predisposes,,Methylprednisolone,,,,Inflammation,,,,, -12905337,79,,related to,,Cefotaxime,,,,Sepsis,,,,, -24475300,80,,affects,,Cefotaxime,,,,bacterial infectious disease,,,,, -23922029,81,,affects,,Cefotaxime,,,,Sepsis,,,,, -18672205,82,,affects,,Cefotaxime,,,,peritonitis,,,,, -15853591,83,,prevents,,Cefotaxime,,,,Sepsis,,,,, -19081412,84,,prevents,,Ceftriaxone,,,,bacterial infectious disease,,,,, -25827448,85,,related to,,Gefarnate,,,,gastric ulcer,,,,, -24296137,86,,related to,,Gefarnate,,,,duodenal ulcer,,,,, -25993651,87,,disrupts,,Gefarnate,,,,gastric ulcer,,,,, -17758516,88,,related to,,Neobiotic,,,,Inflammation,,,,, -10690423,89,,related to,,Neobiotic,,,,burn,,,,, -20263460,90,,affects,,Neobiotic,,,,neoplasm,,,,, -19744068,91,,affects,,Neobiotic,,,,Inflammation,,,,, -24669492,92,,disrupts,,Neobiotic,,,,bacterial infectious disease,,,,, -17119153,93,,disrupts,,Neobiotic,,,,neoplasm,,,,, -26428369,94,,prevents,,Neobiotic,,,,bacterial infectious disease,,,,, -25579460,95,,related to,,BLINATUMOMAB,,,,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,,,,, -22474123,96,,related to,,BLINATUMOMAB,,,,hematopoietic and lymphoid system neoplasm,,,,, -21947892,97,,related to,,BLINATUMOMAB,,,,acute lymphoblastic leukemia,,,,, -27155094,98,,related to,,Ciprofloxacin,,,,endophthalmitis,,,,, -16836665,99,,related to,,Ciprofloxacin,,,,Crohn disease,,,,, -19572117,100,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, -19572117,101,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, -12385742,102,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -12385742,103,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -17007621,104,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -17007621,105,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -9387116,106,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -8212496,107,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -25648466,108,,causes,,Ciprofloxacin,,,,abscess,,,,, -24716241,109,,causes,,Ciprofloxacin,,,,peritonitis,,,,, -17154464,110,,causes,,Ciprofloxacin,,,,prostatitis,,,,, -14369807,111,,causes,,Ciprofloxacin,,,,neutropenia,,,,, -13950319,112,,causes,,Ciprofloxacin,,,,pneumonia,,,,, -10209213,113,,causes,,Ciprofloxacin,,,,infectious disease,,,,, -7113733,114,,causes,,Ciprofloxacin,,,,osteomyelitis,,,,, -21996198,115,,affects,,Ciprofloxacin,,,,infectious disease,,,,, -16563368,116,,affects,,Ciprofloxacin,,,,Fever,,,,, -16125923,117,,affects,,Ciprofloxacin,,,,osteomyelitis,,,,, -12942741,118,,affects,,Ciprofloxacin,,,,Crohn disease,,,,, -11440816,119,,affects,,Ciprofloxacin,,,,typhoid fever,,,,, -11267024,120,,affects,,Ciprofloxacin,,,,eye infectious disorder,,,,, -10672042,121,,affects,,Ciprofloxacin,,,,Abdominal Infection,,,,, -9891814,122,,affects,,Ciprofloxacin,,,,pneumonia,,,,, -9122989,123,,affects,,Ciprofloxacin,,,,infectious disease,,,,, -8956826,124,,affects,,Ciprofloxacin,,,,Pseudomonas infection,,,,, -8956825,125,,affects,,Ciprofloxacin,,,,cystic fibrosis,,,,, -8669720,126,,affects,,Ciprofloxacin,,,,Fever,,,,, -7886704,127,,affects,,Ciprofloxacin,,,,bronchiectasis,,,,, -7886701,128,,affects,,Ciprofloxacin,,,,chronic bronchitis,,,,, -7781719,129,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, -7592205,130,,affects,,Ciprofloxacin,,,,chronic obstructive pulmonary disease,,,,, -18400322,131,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, -26984478,132,,disrupts,,Ciprofloxacin,,,,Fever,,,,, -26466958,133,,disrupts,,Ciprofloxacin,,,,pneumonia,,,,, -18480207,134,,disrupts,,Ciprofloxacin,,,,infectious disease,,,,, -10323767,135,,disrupts,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, -27242944,136,,prevents,,Ciprofloxacin,,,,pyelonephritis,,,,, -21807033,137,,prevents,,Ciprofloxacin,,,,Infection,,,,, -16138544,138,,prevents,,Ciprofloxacin,,,,diarrheal disease,,,,, -15438014,139,,prevents,,Ciprofloxacin,,,,Sepsis,,,,, -14202377,140,,prevents,,Ciprofloxacin,,,,plague,,,,, -12292532,141,,prevents,,Ciprofloxacin,,,,endophthalmitis,,,,, -10767980,142,,prevents,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, -9947057,143,,prevents,,Ciprofloxacin,,,,bacterial infectious disease,,,,, -8364719,144,,prevents,,Ciprofloxacin,,,,pneumonia,,,,, -8054296,145,,prevents,,Ciprofloxacin,,,,infectious disease,,,,, -18366035,146,,predisposes,,Ciprofloxacin,,,,infectious disease,,,,, -15459841,147,,predisposes,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, -8758764,148,,predisposes,,Ciprofloxacin,,,,gonorrhea,,,,, -15493028,149,,disrupts,,Chloramphenicol,,,,acne,,,,, -21241586,150,,prevents,,Chloramphenicol,,,,eye infectious disorder,,,,, -16722213,151,,causes,,Rebamipide,,,,osteoarthritis,,,,, -27679650,152,,affects,,Rebamipide,,,,peptic ulcer disease,,,,, -10125846,153,,affects,,Rebamipide,,,,gastric ulcer,,,,, -16923576,154,,disrupts,,Rebamipide,,,,gastritis,,,,, -20953135,155,,prevents,,Rebamipide,,,,peptic ulcer disease,,,,, -13727344,156,,prevents,,Rebamipide,,,,gastritis,,,,, -10452606,157,,prevents,,Rebamipide,,,,gastric ulcer,,,,, -23020953,158,,related to,,DINUTUXIMAB,,,,neoplasm,,,,, -12385638,159,,related to,,DINUTUXIMAB,,,,neuroblastoma,,,,, -21974466,160,,causes,,DINUTUXIMAB,,,,neuroblastoma,,,,, -23929422,161,,related to,,BRENTUXIMAB VEDOTIN,,,,anaplastic large cell lymphoma,,,,, -23730531,162,,related to,,BRENTUXIMAB VEDOTIN,,,,mycosis fungoides,,,,, -23653011,163,,related to,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, -23065539,164,,related to,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, -21812241,165,,related to,,BRENTUXIMAB VEDOTIN,,,,Hodgkins lymphoma,,,,, -21657994,166,,related to,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -21657993,167,,related to,,BRENTUXIMAB VEDOTIN,,,,primary cutaneous T-cell non-Hodgkin lymphoma,,,,, -22071488,168,,has part,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -21553377,169,,has part,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, -23435913,170,,affects,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, -20170701,171,,causes,,Tetracycline,,,,periodontitis,,,,, -19472933,172,,causes,,Tetracycline,,,,Helicobacter pylori infectious disease,,,,, -18080767,173,,affects,,Tetracycline,,,,periodontitis,,,,, -17969405,174,,affects,,Tetracycline,,,,bacterial infectious disease,,,,, -24565223,175,,prevents,,Tetracycline,,,,bacterial infectious disease,,,,, -10847016,176,,prevents,,Tetracycline,,,,inclusion conjunctivitis,,,,, -12376615,177,,related to,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -11754791,178,,related to,,(Alginate)n,,,,cystic fibrosis,,,,, -10599430,179,,related to,,(Alginate)n,,,,obesity disorder,,,,, -27435796,180,,affects,,(Alginate)n,,,,cystic fibrosis,,,,, -27132270,181,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -23415127,182,,affects,,(Alginate)n,,,,obesity disorder,,,,, -19854419,183,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -8246131,184,,disrupts,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -11492096,185,,prevents,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -23508922,186,,predisposes,,(Alginate)n,,,,obesity disorder,,,,, -11597598,187,,related to,,Zolimidine,,,,peptic ulcer disease,,,,, -20742970,188,,causes,,Chlorhexidine,,,,infectious disease,,,,, -16147932,189,,causes,,Chlorhexidine,,,,gingivitis,,,,, -15413413,190,,causes,,Chlorhexidine,,,,stomatitis,,,,, -13735208,191,,causes,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, -23793676,192,,affects,,Chlorhexidine,,,,Infection,,,,, -21319017,193,,affects,,Chlorhexidine,,,,pneumonia,,,,, -20585434,194,,affects,,Chlorhexidine,,,,stomatitis,,,,, -13503760,195,,affects,,Chlorhexidine,,,,periodontal disorder,,,,, -8506996,196,,affects,,Chlorhexidine,,,,gingivitis,,,,, -25489531,197,,disrupts,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, -22304373,198,,disrupts,,Chlorhexidine,,,,dental caries,,,,, -21939464,199,,disrupts,,Chlorhexidine,,,,Infection,,,,, -19793680,200,,disrupts,,Chlorhexidine,,,,bacterial infectious disease,,,,, -18040358,201,,disrupts,,Chlorhexidine,,,,infectious disease,,,,, -11272633,202,,disrupts,,Chlorhexidine,,,,gingivitis,,,,, -26042520,203,,prevents,,Chlorhexidine,,,,staphylococcal infection,,,,, -22617089,204,,prevents,,Chlorhexidine,,,,periodontitis,,,,, -22038778,205,,prevents,,Chlorhexidine,,,,bacterial infectious disease,,,,, -22000060,206,,prevents,,Chlorhexidine,,,,Infection,,,,, -21737487,207,,prevents,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, -19905103,208,,prevents,,Chlorhexidine,,,,periodontal disorder,,,,, -16765643,209,,prevents,,Chlorhexidine,,,,Neonatal sepsis,,,,, -14052320,210,,prevents,,Chlorhexidine,,,,pneumonia,,,,, -11830955,211,,prevents,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, -11145796,212,,prevents,,Chlorhexidine,,,,infectious disease,,,,, -10739867,213,,prevents,,Chlorhexidine,,,,stomatitis,,,,, -10141569,214,,prevents,,Chlorhexidine,,,,dental caries,,,,, -7990742,215,,prevents,,Chlorhexidine,,,,gingivitis,,,,, -23454202,216,,predisposes,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, -19942414,217,,predisposes,,Chlorhexidine,,,,periodontal disorder,,,,, -18735040,218,,predisposes,,Chlorhexidine,,,,dental caries,,,,, -16765642,219,,predisposes,,Chlorhexidine,,,,Neonatal sepsis,,,,, -24905090,220,,causes,,Nicergoline,,,,depressive disorder,,,,, -25103280,221,,related to,,RAMUCIRUMAB,,,,hepatocellular carcinoma,,,,, -22612331,222,,related to,,RAMUCIRUMAB,,,,neoplasm,,,,, -21600131,223,,related to,,RAMUCIRUMAB,,,,non-small cell lung carcinoma,,,,, -22008312,224,,affects,,RAMUCIRUMAB,,,,neoplasm,,,,, -23569571,225,,related to,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, -24533103,226,,disrupts,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, -21884997,227,,related to,,Thioctic acid,,,,cystinuria,,,,, -20207321,228,,related to,,Thioctic acid,,,,chronic progressive multiple sclerosis,,,,, -18115881,229,,related to,,Thioctic acid,,,,hypertensive disorder,,,,, -15406106,230,,related to,,Thioctic acid,,,,optic neuritis,,,,, -12204809,231,,related to,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, -11741203,232,,related to,,Thioctic acid,,,,multiple sclerosis,,,,, -11010945,233,,related to,,Thioctic acid,,,,AIDS,,,,, -10648973,234,,related to,,Thioctic acid,,,,skin disorder,,,,, -7603472,235,,related to,,Thioctic acid,,,,diabetic neuropathy,,,,, -16842192,236,,causes,,Thioctic acid,,,,hypertensive disorder,,,,, -21111426,237,,affects,,Thioctic acid,,,,optic neuritis,,,,, -18505755,238,,affects,,Thioctic acid,,,,diabetic neuropathy,,,,, -17198477,239,,affects,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, -12393284,240,,affects,,Thioctic acid,,,,Alzheimer disease,,,,, -9028391,241,,affects,,Thioctic acid,,,,hypertensive disorder,,,,, -21111429,242,,prevents,,Thioctic acid,,,,optic neuritis,,,,, -18775341,243,,prevents,,Thioctic acid,,,,skin disorder,,,,, -18076378,244,,prevents,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, -15377554,245,,prevents,,Thioctic acid,,,,stroke disorder,,,,, -13878249,246,,prevents,,Thioctic acid,,,,Alzheimer disease,,,,, -8826102,247,,prevents,,Thioctic acid,,,,hypertensive disorder,,,,, -8682086,248,,prevents,,Thioctic acid,,,,diabetic neuropathy,,,,, -15385084,249,,predisposes,,Thioctic acid,,,,Alzheimer disease,,,,, -26276598,250,,related to,,Ampicillin,,,,Sepsis,,,,, -19644222,251,,related to,,Ampicillin,,,,pneumonia,,,,, -27702232,252,,causes,,Ampicillin,,,,Sepsis,,,,, -15854005,253,,causes,,Ampicillin,,,,pneumonia,,,,, -14938843,254,,affects,,Ampicillin,,,,Sepsis,,,,, -8930713,255,,affects,,Ampicillin,,,,gonorrhea,,,,, -21012437,256,,disrupts,,Ampicillin,,,,gonorrhea,,,,, -24823382,257,,prevents,,Ampicillin,,,,Infection,,,,, -22838487,258,,prevents,,Ampicillin,,,,chorioamnionitis,,,,, -18801502,259,,prevents,,Ampicillin,,,,Sepsis,,,,, -17465667,260,,prevents,,Ampicillin,,,,pneumonia,,,,, -13675414,261,,predisposes,,Ampicillin,,,,Sepsis,,,,, -26048573,262,,causes,,Carbenicillin,,,,bacterial infectious disease,,,,, -19319362,263,,related to,,Benzoyl Peroxide,,,,acne,,,,, -10427135,264,,affects,,Benzoyl Peroxide,,,,acne,,,,, -7769964,265,,disrupts,,Benzoyl Peroxide,,,,acne,,,,, -12531968,266,,prevents,,Benzoyl Peroxide,,,,acne,,,,, -11597597,267,,related to,,Proglumide,,,,peptic ulcer disease,,,,, -18195146,268,,causes,,Pirenzepine,,,,peptic ulcer disease,,,,, -13022427,269,,affects,,Pirenzepine,,,,gastroesophageal reflux disease,,,,, -18547780,270,,prevents,,Pirenzepine,,,,peptic ulcer disease,,,,, -9345084,271,,related to,,Magnesium Oxide,,,,constipation disorder,,,,, -19628284,272,,disrupts,,Magnesium Oxide,,,,constipation disorder,,,,, -25714783,273,,prevents,,Ticarcillin,,,,Sepsis,,,,, -24735602,274,,related to,,Urea,,,,hepatocellular carcinoma,,,,, -18901918,275,,related to,,Urea,,,,radiodermatitis,,,,, -16423422,276,,related to,,Urea,,,,skin disorder,,,,, -16423421,277,,related to,,Urea,,,,psoriasis,,,,, -10983160,278,,related to,,Urea,,,,"dermatitis, atopic",,,,, -9883467,279,,related to,,Urea,,,,diabetes mellitus,,,,, -9435238,280,,related to,,Urea,,,,type 2 diabetes mellitus,,,,, -7778173,281,,related to,,Urea,,,,ornithine carbamoyltransferase deficiency,,,,, -17162115,282,,causes,,Urea,,,,diabetes mellitus,,,,, -16469778,283,,causes,,Urea,,,,type 2 diabetes mellitus,,,,, -18510405,284,,affects,,Urea,,,,hepatocellular carcinoma,,,,, -10531949,285,,affects,,Urea,,,,diabetes mellitus,,,,, -8735554,286,,affects,,Urea,,,,type 2 diabetes mellitus,,,,, -25972859,287,,produces,,Urea,,,,citrullinemia,,,,, -18901919,288,,prevents,,Urea,,,,radiodermatitis,,,,, -15303897,289,,prevents,,Urea,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -19154964,290,,predisposes,,Urea,,,,type 2 diabetes mellitus,,,,, -21175471,291,,related to,,Mannitol,,,,intracranial hypertension,,,,, -17706176,292,,related to,,Mannitol,,,,acute kidney failure,,,,, -17429747,293,,related to,,Mannitol,,,,stroke disorder,,,,, -15130853,294,,related to,,Mannitol,,,,brain cancer,,,,, -13201402,295,,related to,,Mannitol,,,,cystic fibrosis,,,,, -12470912,296,,related to,,Mannitol,,,,brain edema,,,,, -11875924,297,,related to,,Mannitol,,,,ciguatera fish poisoning,,,,, -10780851,298,,related to,,Mannitol,,,,brain injury,,,,, -8946483,299,,related to,,Mannitol,,,,bronchiectasis,,,,, -7891128,300,,related to,,Mannitol,,,,injury,,,,, -26278567,301,,causes,,Mannitol,,,,brain cancer,,,,, -25099324,302,,causes,,Mannitol,,,,hearing loss disorder,,,,, -21259902,303,,causes,,Mannitol,,,,brain injury,,,,, -18351985,304,,causes,,Mannitol,,,,hypotensive disorder,,,,, -15545947,305,,causes,,Mannitol,,,,brain edema,,,,, -12105301,306,,causes,,Mannitol,,,,intracranial hypertension,,,,, -11383337,307,,causes,,Mannitol,,,,injury,,,,, -9825580,308,,causes,,Mannitol,,,,acute kidney failure,,,,, -22439282,309,,affects,,Mannitol,,,,acute kidney failure,,,,, -18431992,310,,affects,,Mannitol,,,,hypotensive disorder,,,,, -10780860,311,,affects,,Mannitol,,,,brain injury,,,,, -10701562,312,,affects,,Mannitol,,,,injury,,,,, -10686125,313,,affects,,Mannitol,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -9315186,314,,affects,,Mannitol,,,,intracranial hypertension,,,,, -7084537,315,,affects,,Mannitol,,,,brain edema,,,,, -27493988,316,,disrupts,,Mannitol,,,,injury,,,,, -26052295,317,,disrupts,,Mannitol,,,,brain edema,,,,, -18331127,318,,prevents,,Mannitol,,,,Pain,,,,, -17838550,319,,prevents,,Mannitol,,,,brain injury,,,,, -9550870,320,,prevents,,Mannitol,,,,acute kidney failure,,,,, -8530867,321,,prevents,,Mannitol,,,,brain edema,,,,, -7816754,322,,prevents,,Mannitol,,,,intracranial hypertension,,,,, -21038220,323,,exacerbates,,Mannitol,,,,intracranial hypertension,,,,, -23554906,324,,predisposes,,Mannitol,,,,brain injury,,,,, -23171283,325,,predisposes,,Mannitol,,,,acute kidney failure,,,,, -15337034,326,,predisposes,,Mannitol,,,,brain edema,,,,, -9368450,327,,predisposes,,Mannitol,,,,injury,,,,, -25560945,328,,affects,,Artesunic acid,,,,neoplasm,,,,, -20380317,329,,affects,,Artesunic acid,,,,neoplasm,,,,, -17022154,330,,affects,,Artesunic acid,,,,cytomegalovirus infection,,,,, -15447136,331,,affects,,Artesunic acid,,,,malaria,,,,, -14695052,332,,affects,,Artesunic acid,,,,Fever,,,,, -9350747,333,,affects,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, -19053159,334,,disrupts,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, -17269195,335,,disrupts,,Artesunic acid,,,,neoplasm,,,,, -16806460,336,,disrupts,,Artesunic acid,,,,malaria,,,,, -10013375,337,,prevents,,Artesunic acid,,,,schistosomiasis,,,,, -8540473,338,,prevents,,Artesunic acid,,,,malaria,,,,, -16567243,339,,predisposes,,Artesunic acid,,,,malaria,,,,, -27639365,340,,affects,,Artemether,,,,Fever,,,,, -25565511,341,,affects,,Artemether,,,,malaria,,,,, -19253720,342,,prevents,,Artemether,,,,malaria,,,,, -10002115,343,,prevents,,Artemether,,,,urinary schistosomiasis,,,,, -8716445,344,,causes,,Isoproterenol,,,,atrial fibrillation,,,,, -25912644,345,,affects,,Isoproterenol,,,,obstructive lung disease,,,,, -24900253,346,,affects,,Isoproterenol,,,,obesity disorder,,,,, -9298156,347,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, -7542857,348,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, -26721271,349,,disrupts,,Isoproterenol,,,,obesity disorder,,,,, -7635739,350,,predisposes,,Isoproterenol,,,,atrial fibrillation,,,,, -23874783,351,,related to,,Bacitracin A,,,,pneumonia,,,,, -26428368,352,,prevents,,Bacitracin A,,,,bacterial infectious disease,,,,, -18829774,353,,prevents,,Bacitracin A,,,,cardiac rhythm disease,,,,, -16650012,354,,subclass of,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, -26133976,355,,causes,,Diflunisal,,,,Pain,,,,, -26132411,356,,affects,,Diflunisal,,,,Pain,,,,, -26009871,357,,affects,,Diflunisal,,,,Fever,,,,, -26009870,358,,affects,,Diflunisal,,,,Fever,,,,, -13234484,359,,affects,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, -14757294,360,,prevents,,Diflunisal,,,,Pain,,,,, -17020332,361,,causes,,Salsalate,,,,Insulin resistance,,,,, -21902985,362,,affects,,Salsalate,,,,diabetes mellitus,,,,, -25541729,363,,disrupts,,Salsalate,,,,Insulin resistance,,,,, -19533984,364,,prevents,,Salsalate,,,,diabetes mellitus,,,,, -26431050,365,,causes,,Sodium salicylate,,,,Fever,,,,, -11882723,366,,affects,,Sodium salicylate,,,,Fever,,,,, -9968696,367,,affects,,Sodium salicylate,,,,Fever,,,,, -15893532,368,,predisposes,,Sodium salicylate,,,,Pain,,,,, -7201382,369,,subclass of,,Aspirin,,,,Salicylic Acid,,,,, -26818861,370,,related to,,Aspirin,,,,myocardial infarction,,,,, -26532873,371,,related to,,Aspirin,,,,classic familial adenomatous polyposis,,,,, -26329928,372,,related to,,Aspirin,,,,type 2 diabetes mellitus,,,,, -26168722,373,,related to,,Aspirin,,,,Inflammation,,,,, -24076103,374,,related to,,Aspirin,,,,Hemorrhage,,,,, -20241570,375,,related to,,Aspirin,,,,Pain,,,,, -18524506,376,,related to,,Aspirin,,,,cataract,,,,, -18008074,377,,related to,,Aspirin,,,,diabetes mellitus,,,,, -17483160,378,,related to,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, -16078277,379,,related to,,Aspirin,,,,preeclampsia,,,,, -15283505,380,,related to,,Aspirin,,,,thrombotic disease,,,,, -13829413,381,,related to,,Aspirin,,,,retinal vein occlusion,,,,, -13174915,382,,related to,,Aspirin,,,,ST-elevation myocardial infarction,,,,, -12865539,383,,related to,,Aspirin,,,,cardiovascular disorder,,,,, -12749655,384,,related to,,Aspirin,,,,Salicylic Acid,,,,, -12502970,385,,related to,,Aspirin,,,,coronary artery disorder,,,,, -10635434,386,,related to,,Aspirin,,,,rheumatic heart disease,,,,, -10534181,387,,related to,,Aspirin,,,,osteoarthritis,,,,, -10473195,388,,related to,,Aspirin,,,,asthma,,,,, -9315521,389,,related to,,Aspirin,,,,atrial fibrillation,,,,, -8718389,390,,related to,,Aspirin,,,,stroke disorder,,,,, -8430499,391,,related to,,Aspirin,,,,Ischemic stroke,,,,, -7718877,392,,related to,,Aspirin,,,,acute coronary syndrome,,,,, -8745735,393,,related to,,Aspirin,,,,Salicylic Acid,,,,, -12749656,394,,close match,,Aspirin,,,,Salicylic Acid,,,,, -8745736,395,,close match,,Aspirin,,,,Salicylic Acid,,,,, -10716638,396,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, -10182446,397,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, -8959647,398,,derives from,,Aspirin,,,,Salicylic Acid,,,,, -7421635,399,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, -9047883,400,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, -27550629,401,,causes,,Aspirin,,,,transient ischemic attack,,,,, -27093984,402,,causes,,Aspirin,,,,Sepsis,,,,, -26941889,403,,causes,,Aspirin,,,,colonic neoplasm,,,,, -26621273,404,,causes,,Aspirin,,,,diabetic retinopathy,,,,, -25682183,405,,causes,,Aspirin,,,,Toothache,,,,, -24276147,406,,causes,,Aspirin,,,,osteoarthritis,,,,, -23603605,407,,causes,,Aspirin,,,,infertility disorder,,,,, -22149437,408,,causes,,Aspirin,,,,myocardial infarction,,,,, -21269587,409,,causes,,Aspirin,,,,preeclampsia,,,,, -21190178,410,,causes,,Aspirin,,,,Varicose Ulcer,,,,, -20967677,411,,causes,,Aspirin,,,,cerebral infarction,,,,, -20453125,412,,causes,,Aspirin,,,,squamous cell carcinoma,,,,, -20257764,413,,causes,,Aspirin,,,,vascular disorder,,,,, -18467493,414,,causes,,Aspirin,,,,periodontitis,,,,, -18133593,415,,causes,,Aspirin,,,,acute lung injury,,,,, -17905974,416,,causes,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, -16266546,417,,causes,,Aspirin,,,,cardiovascular disorder,,,,, -15908394,418,,causes,,Aspirin,,,,arthritic joint disease,,,,, -15782733,419,,causes,,Aspirin,,,,ulcerative colitis,,,,, -15251529,420,,causes,,Aspirin,,,,myocardial ischemia,,,,, -15022291,421,,causes,,Aspirin,,,,pneumonia,,,,, -14953515,422,,causes,,Aspirin,,,,diabetes mellitus,,,,, -14693157,423,,causes,,Aspirin,,,,atrial fibrillation,,,,, -14660024,424,,causes,,Aspirin,,,,ischemic disease,,,,, -14296178,425,,causes,,Aspirin,,,,type 2 diabetes mellitus,,,,, -13914591,426,,causes,,Aspirin,,,,digestive system disorder,,,,, -13814866,427,,causes,,Aspirin,,,,Fever,,,,, -13639281,428,,causes,,Aspirin,,,,acute coronary syndrome,,,,, -13639280,429,,causes,,Aspirin,,,,Ischemic stroke,,,,, -13405854,430,,causes,,Aspirin,,,,hypertensive disorder,,,,, -13278968,431,,causes,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, -11251562,432,,causes,,Aspirin,,,,Pain,,,,, -10850020,433,,causes,,Aspirin,,,,migraine disorder,,,,, -10555051,434,,causes,,Aspirin,,,,duodenal ulcer,,,,, -9350599,435,,causes,,Aspirin,,,,active peptic ulcer disease,,,,, -9238263,436,,causes,,Aspirin,,,,blood coagulation disease,,,,, -8683872,437,,causes,,Aspirin,,,,stroke disorder,,,,, -8518235,438,,causes,,Aspirin,,,,peptic ulcer disease,,,,, -8466167,439,,causes,,Aspirin,,,,Headache,,,,, -8232293,440,,causes,,Aspirin,,,,Hemorrhage,,,,, -7594346,441,,causes,,Aspirin,,,,asthma,,,,, -7353622,442,,causes,,Aspirin,,,,gastric ulcer,,,,, -7227553,443,,causes,,Aspirin,,,,injury,,,,, -26773149,444,,affects,,Aspirin,,,,atrial fibrillation,,,,, -26425353,445,,affects,,Aspirin,,,,atherosclerosis,,,,, -26396469,446,,affects,,Aspirin,,,,Dysmenorrhea,,,,, -25760183,447,,affects,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -24559876,448,,affects,,Aspirin,,,,coronary artery disorder,,,,, -23119254,449,,affects,,Aspirin,,,,brain aneurysm,,,,, -21758599,450,,affects,,Aspirin,,,,brain aneurysm,,,,, -21116359,451,,affects,,Aspirin,,,,major depressive disorder,,,,, -21116358,452,,affects,,Aspirin,,,,schizophrenia,,,,, -21031382,453,,affects,,Aspirin,,,,neoplasm,,,,, -20857373,454,,affects,,Aspirin,,,,melanoma,,,,, -20741170,455,,affects,,Aspirin,,,,fetal growth restriction,,,,, -20453126,456,,affects,,Aspirin,,,,squamous cell carcinoma,,,,, -19190473,457,,affects,,Aspirin,,,,acute lung injury,,,,, -18874269,458,,affects,,Aspirin,,,,preeclampsia,,,,, -18830463,459,,affects,,Aspirin,,,,Varicose Ulcer,,,,, -18706529,460,,affects,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, -18617993,461,,affects,,Aspirin,,,,Sepsis,,,,, -18348076,462,,affects,,Aspirin,,,,Headache,,,,, -18344374,463,,affects,,Aspirin,,,,bone fracture,,,,, -18277701,464,,affects,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, -18092588,465,,affects,,Aspirin,,,,Fever,,,,, -17810437,466,,affects,,Aspirin,,,,migraine disorder,,,,, -16655533,467,,affects,,Aspirin,,,,stroke disorder,,,,, -16466986,468,,affects,,Aspirin,,,,myocardial ischemia,,,,, -16123563,469,,affects,,Aspirin,,,,digestive system disorder,,,,, -15829936,470,,affects,,Aspirin,,,,hypertriglyceridemia,,,,, -15667690,471,,affects,,Aspirin,,,,hepatocellular carcinoma,,,,, -15311732,472,,affects,,Aspirin,,,,periodontitis,,,,, -15094783,473,,affects,,Aspirin,,,,diabetic retinopathy,,,,, -13831910,474,,affects,,Aspirin,,,,gastric ulcer,,,,, -13734334,475,,affects,,Aspirin,,,,Pregnancy,,,,, -13647977,476,,affects,,Aspirin,,,,neoplasm,,,,, -13624111,477,,affects,,Aspirin,,,,pneumonia,,,,, -13559011,478,,affects,,Aspirin,,,,type 2 diabetes mellitus,,,,, -13493823,479,,affects,,Aspirin,,,,thrombotic disease,,,,, -12884495,480,,affects,,Aspirin,,,,duodenal ulcer,,,,, -12815469,481,,affects,,Aspirin,,,,atherosclerosis,,,,, -12769418,482,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, -12607959,483,,affects,,Aspirin,,,,plasma cell myeloma,,,,, -12446363,484,,affects,,Aspirin,,,,hypertensive disorder,,,,, -12124867,485,,affects,,Aspirin,,,,heart disorder,,,,, -11661767,486,,affects,,Aspirin,,,,peptic ulcer disease,,,,, -11474111,487,,affects,,Aspirin,,,,diabetes mellitus,,,,, -11357781,488,,affects,,Aspirin,,,,ischemic disease,,,,, -11341534,489,,affects,,Aspirin,,,,ulcer disease,,,,, -11135514,490,,affects,,Aspirin,,,,cerebrovascular disorder,,,,, -10875862,491,,affects,,Aspirin,,,,acquired polycythemia vera,,,,, -10830878,492,,affects,,Aspirin,,,,Inflammation,,,,, -10337669,493,,affects,,Aspirin,,,,colorectal neoplasm,,,,, -10331252,494,,affects,,Aspirin,,,,peptic ulcer disease,,,,, -10226347,495,,affects,,Aspirin,,,,thrombophilia,,,,, -10082315,496,,affects,,Aspirin,,,,Pain,,,,, -10068618,497,,affects,,Aspirin,,,,adenoma,,,,, -9766251,498,,affects,,Aspirin,,,,injury,,,,, -9581221,499,,affects,,Aspirin,,,,cataract,,,,, -9528323,500,,affects,,Aspirin,,,,asthma,,,,, -9510044,501,,affects,,Aspirin,,,,transient ischemic attack,,,,, -9342553,502,,affects,,Aspirin,,,,Salicylic Acid,,,,, -9259288,503,,affects,,Aspirin,,,,Fever,,,,, -9203900,504,,affects,,Aspirin,,,,Hypercholesterolemia,,,,, -9160463,505,,affects,,Aspirin,,,,gastric ulcer,,,,, -9084341,506,,affects,,Aspirin,,,,Ischemic stroke,,,,, -8650258,507,,affects,,Aspirin,,,,Hemorrhage,,,,, -8543326,508,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, -8290962,509,,affects,,Aspirin,,,,ulcer disease,,,,, -8187935,510,,affects,,Aspirin,,,,injury,,,,, -8173134,511,,affects,,Aspirin,,,,thrombotic disease,,,,, -8169760,512,,affects,,Aspirin,,,,preeclampsia,,,,, -7935107,513,,affects,,Aspirin,,,,prostate cancer,,,,, -7920712,514,,affects,,Aspirin,,,,Hemorrhage,,,,, -7876600,515,,affects,,Aspirin,,,,Hemorrhage,,,,, -7820545,516,,affects,,Aspirin,,,,vascular disorder,,,,, -7816175,517,,affects,,Aspirin,,,,Pregnancy,,,,, -7635677,518,,affects,,Aspirin,,,,myocardial ischemia,,,,, -7478885,519,,affects,,Aspirin,,,,coronary artery disorder,,,,, -7468514,520,,affects,,Aspirin,,,,stroke disorder,,,,, -7251569,521,,affects,,Aspirin,,,,myocardial infarction,,,,, -7213554,522,,affects,,Aspirin,,,,cardiovascular disorder,,,,, -7156429,523,,affects,,Aspirin,,,,Inflammation,,,,, -14159165,524,,affects,,Aspirin,,,,Salicylic Acid,,,,, -27335099,525,,disrupts,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -24958273,526,,disrupts,,Aspirin,,,,Fever,,,,, -24520178,527,,disrupts,,Aspirin,,,,melanoma,,,,, -24047967,528,,disrupts,,Aspirin,,,,cardiovascular disorder,,,,, -22107293,529,,disrupts,,Aspirin,,,,atrial fibrillation,,,,, -22100738,530,,disrupts,,Aspirin,,,,fetal growth restriction,,,,, -22027792,531,,disrupts,,Aspirin,,,,venous thromboembolism,,,,, -21434441,532,,disrupts,,Aspirin,,,,thrombophilia,,,,, -20385507,533,,disrupts,,Aspirin,,,,essential thrombocythemia,,,,, -19437129,534,,disrupts,,Aspirin,,,,Sepsis,,,,, -19421638,535,,disrupts,,Aspirin,,,,pneumonia,,,,, -19318532,536,,disrupts,,Aspirin,,,,vascular disorder,,,,, -18604728,537,,disrupts,,Aspirin,,,,type 2 diabetes mellitus,,,,, -18599969,538,,disrupts,,Aspirin,,,,arthritic joint disease,,,,, -18445880,539,,disrupts,,Aspirin,,,,ovarian cancer,,,,, -18225861,540,,disrupts,,Aspirin,,,,Hemorrhage,,,,, -18203584,541,,disrupts,,Aspirin,,,,brain aneurysm,,,,, -17476286,542,,disrupts,,Aspirin,,,,Fatigue,,,,, -17225706,543,,disrupts,,Aspirin,,,,transient ischemic attack,,,,, -16676314,544,,disrupts,,Aspirin,,,,ulcer disease,,,,, -16484307,545,,disrupts,,Aspirin,,,,acute lung injury,,,,, -14296080,546,,disrupts,,Aspirin,,,,Pregnancy,,,,, -14068900,547,,disrupts,,Aspirin,,,,active peptic ulcer disease,,,,, -13892678,548,,disrupts,,Aspirin,,,,breast neoplasm,,,,, -13449558,549,,disrupts,,Aspirin,,,,colorectal neoplasm,,,,, -12947740,550,,disrupts,,Aspirin,,,,diabetic retinopathy,,,,, -12815470,551,,disrupts,,Aspirin,,,,atherosclerosis,,,,, -12714476,552,,disrupts,,Aspirin,,,,cataract,,,,, -12478523,553,,disrupts,,Aspirin,,,,preeclampsia,,,,, -12450426,554,,disrupts,,Aspirin,,,,Barrett esophagus,,,,, -12023670,555,,disrupts,,Aspirin,,,,hypertensive disorder,,,,, -11827133,556,,disrupts,,Aspirin,,,,diabetes mellitus,,,,, -10318928,557,,disrupts,,Aspirin,,,,Myalgia,,,,, -9742254,558,,disrupts,,Aspirin,,,,adenoma,,,,, -9148614,559,,disrupts,,Aspirin,,,,neoplasm,,,,, -8526818,560,,disrupts,,Aspirin,,,,myocardial infarction,,,,, -7995298,561,,disrupts,,Aspirin,,,,Inflammation,,,,, -7878103,562,,disrupts,,Aspirin,,,,prostate cancer,,,,, -7775480,563,,disrupts,,Aspirin,,,,Pain,,,,, -7723340,564,,disrupts,,Aspirin,,,,stroke disorder,,,,, -7712646,565,,disrupts,,Aspirin,,,,coronary artery disorder,,,,, -7261879,566,,disrupts,,Aspirin,,,,thrombotic disease,,,,, -24597938,567,,prevents,,Aspirin,,,,thrombophilia,,,,, -24091248,568,,prevents,,Aspirin,,,,disseminated intravascular coagulation,,,,, -24015329,569,,prevents,,Aspirin,,,,neoplasm of esophagus,,,,, -23042755,570,,prevents,,Aspirin,,,,brain aneurysm,,,,, -22291835,571,,prevents,,Aspirin,,,,Hemorrhage,,,,, -21962376,572,,prevents,,Aspirin,,,,venous thromboembolism,,,,, -21587985,573,,prevents,,Aspirin,,,,blood coagulation disease,,,,, -21116357,574,,prevents,,Aspirin,,,,schizophrenia,,,,, -20356983,575,,prevents,,Aspirin,,,,acute lung injury,,,,, -20189716,576,,prevents,,Aspirin,,,,brain infarction,,,,, -18414184,577,,prevents,,Aspirin,,,,multiple sclerosis,,,,, -18344373,578,,prevents,,Aspirin,,,,bone fracture,,,,, -17911903,579,,prevents,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, -17240995,580,,prevents,,Aspirin,,,,hepatocellular carcinoma,,,,, -16163718,581,,prevents,,Aspirin,,,,Sepsis,,,,, -15608454,582,,prevents,,Aspirin,,,,squamous cell carcinoma,,,,, -14796348,583,,prevents,,Aspirin,,,,arthritic joint disease,,,,, -14183452,584,,prevents,,Aspirin,,,,pneumonia,,,,, -13992680,585,,prevents,,Aspirin,,,,diabetes mellitus,,,,, -13992679,586,,prevents,,Aspirin,,,,type 2 diabetes mellitus,,,,, -13770407,587,,prevents,,Aspirin,,,,diabetic retinopathy,,,,, -13624060,588,,prevents,,Aspirin,,,,injury,,,,, -13536062,589,,prevents,,Aspirin,,,,non-small cell lung carcinoma,,,,, -13041448,590,,prevents,,Aspirin,,,,atrial fibrillation,,,,, -12791249,591,,prevents,,Aspirin,,,,asthma,,,,, -12594676,592,,prevents,,Aspirin,,,,Fatigue,,,,, -12361944,593,,prevents,,Aspirin,,,,active peptic ulcer disease,,,,, -12273189,594,,prevents,,Aspirin,,,,Myalgia,,,,, -11593026,595,,prevents,,Aspirin,,,,colorectal neoplasm,,,,, -11289178,596,,prevents,,Aspirin,,,,migraine disorder,,,,, -11042545,597,,prevents,,Aspirin,,,,Barrett esophagus,,,,, -10366572,598,,prevents,,Aspirin,,,,cerebrovascular disorder,,,,, -10293726,599,,prevents,,Aspirin,,,,prostate cancer,,,,, -10185706,600,,prevents,,Aspirin,,,,colonic neoplasm,,,,, -10099399,601,,prevents,,Aspirin,,,,atherosclerosis,,,,, -10096705,602,,prevents,,Aspirin,,,,cerebral infarction,,,,, -10004143,603,,prevents,,Aspirin,,,,blindness (disorder),,,,, -9665356,604,,prevents,,Aspirin,,,,hypertensive disorder,,,,, -9388878,605,,prevents,,Aspirin,,,,coronary artery disorder,,,,, -9150304,606,,prevents,,Aspirin,,,,habitual spontaneous abortion,,,,, -8853513,607,,prevents,,Aspirin,,,,gastric ulcer,,,,, -8755758,608,,prevents,,Aspirin,,,,vascular disorder,,,,, -8494726,609,,prevents,,Aspirin,,,,ulcer disease,,,,, -8347839,610,,prevents,,Aspirin,,,,peptic ulcer disease,,,,, -8325441,611,,prevents,,Aspirin,,,,ischemic disease,,,,, -7877588,612,,prevents,,Aspirin,,,,cardiovascular disorder,,,,, -7852267,613,,prevents,,Aspirin,,,,Headache,,,,, -7716613,614,,prevents,,Aspirin,,,,neoplasm,,,,, -7603499,615,,prevents,,Aspirin,,,,myocardial ischemia,,,,, -7487700,616,,prevents,,Aspirin,,,,Inflammation,,,,, -7457050,617,,prevents,,Aspirin,,,,peripheral vascular disease,,,,, -7455467,618,,prevents,,Aspirin,,,,Ischemic stroke,,,,, -7455466,619,,prevents,,Aspirin,,,,stroke disorder,,,,, -7455465,620,,prevents,,Aspirin,,,,transient ischemic attack,,,,, -7419265,621,,prevents,,Aspirin,,,,heart disorder,,,,, -7368248,622,,prevents,,Aspirin,,,,thrombotic disease,,,,, -7317027,623,,prevents,,Aspirin,,,,preeclampsia,,,,, -7275741,624,,prevents,,Aspirin,,,,acute coronary syndrome,,,,, -7264064,625,,prevents,,Aspirin,,,,Pain,,,,, -7196018,626,,prevents,,Aspirin,,,,myocardial infarction,,,,, -7159192,627,,prevents,,Aspirin,,,,fetal growth restriction,,,,, -7110859,628,,prevents,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -22126985,629,,exacerbates,,Aspirin,,,,gastric ulcer,,,,, -21411566,630,,exacerbates,,Aspirin,,,,macular degeneration,,,,, -21359197,631,,exacerbates,,Aspirin,,,,acute coronary syndrome,,,,, -26115547,632,,predisposes,,Aspirin,,,,cerebral infarction,,,,, -25254777,633,,predisposes,,Aspirin,,,,essential thrombocythemia,,,,, -23315977,634,,predisposes,,Aspirin,,,,brain aneurysm,,,,, -21525767,635,,predisposes,,Aspirin,,,,Fever,,,,, -21487721,636,,predisposes,,Aspirin,,,,Hemorrhage,,,,, -20679052,637,,predisposes,,Aspirin,,,,blood coagulation disease,,,,, -20234206,638,,predisposes,,Aspirin,,,,hepatocellular carcinoma,,,,, -20155873,639,,predisposes,,Aspirin,,,,placental insufficiency,,,,, -19346376,640,,predisposes,,Aspirin,,,,chronic renal failure syndrome,,,,, -18235965,641,,predisposes,,Aspirin,,,,macular degeneration,,,,, -17872103,642,,predisposes,,Aspirin,,,,atrial fibrillation,,,,, -17123250,643,,predisposes,,Aspirin,,,,acute coronary syndrome,,,,, -16813141,644,,predisposes,,Aspirin,,,,melanoma,,,,, -16162173,645,,predisposes,,Aspirin,,,,ulcerative colitis,,,,, -15461534,646,,predisposes,,Aspirin,,,,gastric ulcer,,,,, -14856258,647,,predisposes,,Aspirin,,,,neoplasm of esophagus,,,,, -14426809,648,,predisposes,,Aspirin,,,,neoplasm,,,,, -14234947,649,,predisposes,,Aspirin,,,,diabetes mellitus,,,,, -14126301,650,,predisposes,,Aspirin,,,,cerebrovascular disorder,,,,, -14052964,651,,predisposes,,Aspirin,,,,Inflammation,,,,, -14015029,652,,predisposes,,Aspirin,,,,transient ischemic attack,,,,, -13644771,653,,predisposes,,Aspirin,,,,asthma,,,,, -13536064,654,,predisposes,,Aspirin,,,,non-small cell lung carcinoma,,,,, -13299957,655,,predisposes,,Aspirin,,,,ovarian cancer,,,,, -12673405,656,,predisposes,,Aspirin,,,,bone fracture,,,,, -12382415,657,,predisposes,,Aspirin,,,,colorectal neoplasm,,,,, -11071059,658,,predisposes,,Aspirin,,,,injury,,,,, -10962122,659,,predisposes,,Aspirin,,,,ischemic disease,,,,, -10547299,660,,predisposes,,Aspirin,,,,coronary artery disorder,,,,, -10337650,661,,predisposes,,Aspirin,,,,adenoma,,,,, -9857077,662,,predisposes,,Aspirin,,,,vascular disorder,,,,, -9535755,663,,predisposes,,Aspirin,,,,thrombotic disease,,,,, -9535754,664,,predisposes,,Aspirin,,,,hypertensive disorder,,,,, -9491661,665,,predisposes,,Aspirin,,,,cardiovascular disorder,,,,, -9477464,666,,predisposes,,Aspirin,,,,prostate cancer,,,,, -9404829,667,,predisposes,,Aspirin,,,,ulcer disease,,,,, -8850172,668,,predisposes,,Aspirin,,,,myocardial ischemia,,,,, -8763743,669,,predisposes,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -8545255,670,,predisposes,,Aspirin,,,,Ischemic stroke,,,,, -7865543,671,,predisposes,,Aspirin,,,,Headache,,,,, -7858710,672,,predisposes,,Aspirin,,,,myocardial infarction,,,,, -7667039,673,,predisposes,,Aspirin,,,,preeclampsia,,,,, -7659453,674,,predisposes,,Aspirin,,,,stroke disorder,,,,, -7653535,675,,predisposes,,Aspirin,,,,peptic ulcer disease,,,,, -7596288,676,,predisposes,,Aspirin,,,,atherosclerosis,,,,, -7078619,677,,predisposes,,Aspirin,,,,active peptic ulcer disease,,,,, -23297288,678,,prevents,,Vemurafenib,,,,neoplasm,,,,, -22851133,679,,related to,,Dabrafenib,,,,melanoma,,,,, -18622575,680,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -18622575,681,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -26359747,682,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -26359747,683,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -24697302,684,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -24697302,685,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -10513644,686,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -10513644,687,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -15306394,688,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -15306394,689,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -10518221,690,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -9906740,691,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -8278260,692,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -9085295,693,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -25915149,694,,related to,,Sodium monofluorophosphate,,,,dental caries,,,,, -25861359,695,,disrupts,,Sodium monofluorophosphate,,,,allergic disease,,,,, -19241020,696,,related to,,Sodium Fluoride,,,,gingivitis,,,,, -17448182,697,,related to,,Sodium Fluoride,,,,aortic valve stenosis,,,,, -9111981,698,,related to,,Sodium Fluoride,,,,dental caries,,,,, -25583763,699,,causes,,Sodium Fluoride,,,,dental fluorosis,,,,, -23780312,700,,affects,,Sodium Fluoride,,,,dental caries,,,,, -18846793,701,,affects,,Sodium Fluoride,,,,allergic disease,,,,, -25986070,702,,disrupts,,Sodium Fluoride,,,,allergic disease,,,,, -14286543,703,,prevents,,Sodium Fluoride,,,,gingivitis,,,,, -10538561,704,,prevents,,Sodium Fluoride,,,,periodontal disorder,,,,, -10425615,705,,prevents,,Sodium Fluoride,,,,dental caries,,,,, -19971424,706,,related to,,Rifaximin,,,,irritable bowel syndrome,,,,, -17053293,707,,related to,,Rifaximin,,,,hepatic encephalopathy,,,,, -18714048,708,,causes,,Rifaximin,,,,irritable bowel syndrome,,,,, -8925773,709,,causes,,Rifaximin,,,,diarrheal disease,,,,, -25434952,710,,affects,,Rifaximin,,,,alcoholic hepatitis,,,,, -24257624,711,,affects,,Rifaximin,,,,Infection,,,,, -20149851,712,,affects,,Rifaximin,,,,Crohn disease,,,,, -19665399,713,,affects,,Rifaximin,,,,diverticulitis,,,,, -18685028,714,,affects,,Rifaximin,,,,irritable bowel syndrome,,,,, -16575444,715,,affects,,Rifaximin,,,,hepatic encephalopathy,,,,, -21278571,716,,prevents,,Rifaximin,,,,alcoholic hepatitis,,,,, -16143515,717,,prevents,,Rifaximin,,,,diverticulitis,,,,, -15134586,718,,prevents,,Rifaximin,,,,hepatic encephalopathy,,,,, -11830138,719,,prevents,,Rifaximin,,,,irritable bowel syndrome,,,,, -11830137,720,,prevents,,Rifaximin,,,,diarrheal disease,,,,, -15717459,721,,predisposes,,Rifaximin,,,,hepatic encephalopathy,,,,, -25706307,722,,related to,,Glycine,,,,cystic fibrosis,,,,, -20102524,723,,related to,,Glycine,,,,psychotic disorder,,,,, -17514096,724,,related to,,Glycine,,,,hypertensive disorder,,,,, -13080824,725,,related to,,Glycine,,,,Alzheimer disease,,,,, -12589996,726,,related to,,Glycine,,,,nutritional disorder,,,,, -7298031,727,,related to,,Glycine,,,,schizophrenia,,,,, -17397486,728,,causes,,Glycine,,,,Cognitive impairment,,,,, -17125423,729,,affects,,Glycine,,,,asthma,,,,, -7530162,730,,affects,,Glycine,,,,schizophrenia,,,,, -12589998,731,,produces,,Glycine,,,,nutritional disorder,,,,, -16845009,732,,disrupts,,Glycine,,,,Alzheimer disease,,,,, -12278394,733,,prevents,,Glycine,,,,hypertensive disorder,,,,, -15546112,734,,predisposes,,Glycine,,,,asthma,,,,, -16711324,735,,related to,,Sorbitol,,,,injury,,,,, -10684679,736,,related to,,Sorbitol,,,,constipation disorder,,,,, -20821510,737,,causes,,Sorbitol,,,,constipation disorder,,,,, -15564538,738,,causes,,Sorbitol,,,,injury,,,,, -17658899,739,,affects,,Sorbitol,,,,osteoarthritis,,,,, -26106951,740,,prevents,,Sorbitol,,,,injury,,,,, -10478248,741,,affects,,Foscarnet,,,,cytomegalovirus infection,,,,, -10481132,742,,prevents,,Foscarnet,,,,cytomegalovirus infection,,,,, -22857734,743,,prevents,,Atogepant,,,,migraine disorder,,,,, -25325960,744,,prevents,,Rimegepant,,,,migraine disorder,,,,, -21939131,745,,prevents,,Rimegepant,,,,Pain,,,,, -10553741,746,,related to,,ATROPINE,,,,poisoning,,,,, -19468294,747,,causes,,ATROPINE,,,,Pain,,,,, -18989245,748,,causes,,ATROPINE,,,,digestive system disorder,,,,, -14576640,749,,causes,,ATROPINE,,,,myopia,,,,, -10716177,750,,causes,,ATROPINE,,,,Mydriasis,,,,, -10361041,751,,causes,,ATROPINE,,,,amblyopia,,,,, -9746341,752,,causes,,ATROPINE,,,,poisoning,,,,, -9301311,753,,causes,,ATROPINE,,,,cardiac arrest,,,,, -8524259,754,,causes,,ATROPINE,,,,Insulin resistance,,,,, -8480152,755,,causes,,ATROPINE,,,,Bradycardia,,,,, -26343406,756,,affects,,ATROPINE,,,,hypoglycemia,,,,, -23118209,757,,affects,,ATROPINE,,,,Mydriasis,,,,, -19520979,758,,affects,,ATROPINE,,,,hypoglycemia,,,,, -12406813,759,,affects,,ATROPINE,,,,cardiac arrest,,,,, -11741867,760,,affects,,ATROPINE,,,,Bradycardia,,,,, -10264479,761,,affects,,ATROPINE,,,,Hemorrhage,,,,, -9293832,762,,affects,,ATROPINE,,,,poisoning,,,,, -9041302,763,,affects,,ATROPINE,,,,Bradycardia,,,,, -7845760,764,,affects,,ATROPINE,,,,Bradycardia,,,,, -7111083,765,,affects,,ATROPINE,,,,myopia,,,,, -26141463,766,,disrupts,,ATROPINE,,,,hypoglycemia,,,,, -23143978,767,,disrupts,,ATROPINE,,,,poisoning,,,,, -20133204,768,,disrupts,,ATROPINE,,,,Pain,,,,, -18168420,769,,disrupts,,ATROPINE,,,,Bradycardia,,,,, -7111084,770,,disrupts,,ATROPINE,,,,myopia,,,,, -9676858,771,,prevents,,ATROPINE,,,,poisoning,,,,, -9198373,772,,prevents,,ATROPINE,,,,myopia,,,,, -8451883,773,,prevents,,ATROPINE,,,,cardiac arrest,,,,, -23699298,774,,predisposes,,ATROPINE,,,,myopia,,,,, -14640163,775,,predisposes,,ATROPINE,,,,poisoning,,,,, -7953996,776,,affects,,Tolcapone,,,,Parkinson disease,,,,, -15643297,777,,related to,,Entacapone,,,,Parkinson disease,,,,, -10033650,778,,causes,,Entacapone,,,,Parkinson disease,,,,, -15952178,779,,affects,,Entacapone,,,,Parkinson disease,,,,, -20308336,780,,disrupts,,Entacapone,,,,Parkinson disease,,,,, -25394620,781,,affects,,Veliparib,,,,neoplasm,,,,, -21697473,782,,affects,,Veliparib,,,,triple-negative breast carcinoma,,,,, -21882624,783,,causes,,Talazoparib,,,,neoplasm,,,,, -22572154,784,,affects,,Talazoparib,,,,neoplasm,,,,, -21697476,785,,affects,,Talazoparib,,,,triple-negative breast carcinoma,,,,, -22916819,786,,prevents,,Talazoparib,,,,neoplasm,,,,, -24451977,787,,related to,,Olaparib,,,,triple-negative breast carcinoma,,,,, -25473017,788,,causes,,Olaparib,,,,pancreatic ductal adenocarcinoma,,,,, -25473016,789,,causes,,Olaparib,,,,non-small cell lung carcinoma,,,,, -22160122,790,,causes,,Olaparib,,,,head and neck neoplasm,,,,, -24770500,791,,affects,,Olaparib,,,,castration-resistant prostate carcinoma,,,,, -24672020,792,,affects,,Olaparib,,,,prostate cancer,,,,, -22977330,793,,affects,,Olaparib,,,,neoplasm,,,,, -21697474,794,,affects,,Olaparib,,,,triple-negative breast carcinoma,,,,, -24201965,795,,prevents,,Olaparib,,,,Neoplasm Metastasis,,,,, -27698235,796,,related to,,Capsaicin,,,,arthritic joint disease,,,,, -22276323,797,,related to,,Capsaicin,,,,herpes zoster,,,,, -13200623,798,,related to,,Capsaicin,,,,migraine disorder,,,,, -11537529,799,,related to,,Capsaicin,,,,Cough,,,,, -10028696,800,,related to,,Capsaicin,,,,diabetic neuropathy,,,,, -8608120,801,,related to,,Capsaicin,,,,osteoarthritis,,,,, -8470968,802,,related to,,Capsaicin,,,,postherpetic neuralgia,,,,, -8246278,803,,related to,,Capsaicin,,,,neuralgia,,,,, -7965643,804,,related to,,Capsaicin,,,,Pruritus,,,,, -7239245,805,,related to,,Capsaicin,,,,Pain,,,,, -26554289,806,,causes,,Capsaicin,,,,stroke disorder,,,,, -24505933,807,,causes,,Capsaicin,,,,Muscle spasm,,,,, -18391785,808,,causes,,Capsaicin,,,,neuralgia,,,,, -16420383,809,,causes,,Capsaicin,,,,migraine disorder,,,,, -11163813,810,,causes,,Capsaicin,,,,arthritic joint disease,,,,, -9650510,811,,causes,,Capsaicin,,,,Myalgia,,,,, -8975038,812,,causes,,Capsaicin,,,,Vomiting,,,,, -8261437,813,,causes,,Capsaicin,,,,Cough,,,,, -7430731,814,,causes,,Capsaicin,,,,Pruritus,,,,, -7414435,815,,causes,,Capsaicin,,,,Pain,,,,, -27524804,816,,affects,,Capsaicin,,,,arthritic joint disease,,,,, -25438971,817,,affects,,Capsaicin,,,,brain injury,,,,, -19404541,818,,affects,,Capsaicin,,,,neuroma,,,,, -15791019,819,,affects,,Capsaicin,,,,Pruritus,,,,, -10951234,820,,affects,,Capsaicin,,,,stroke disorder,,,,, -10764355,821,,affects,,Capsaicin,,,,Pain,,,,, -10290167,822,,affects,,Capsaicin,,,,Pruritus,,,,, -10171204,823,,affects,,Capsaicin,,,,neuralgia,,,,, -8975035,824,,affects,,Capsaicin,,,,Vomiting,,,,, -8515286,825,,affects,,Capsaicin,,,,Pain,,,,, -8515285,826,,affects,,Capsaicin,,,,postherpetic neuralgia,,,,, -8441743,827,,affects,,Capsaicin,,,,Cough,,,,, -7281158,828,,affects,,Capsaicin,,,,Cough,,,,, -18283970,829,,disrupts,,Capsaicin,,,,Pain,,,,, -17652809,830,,disrupts,,Capsaicin,,,,arthritic joint disease,,,,, -14643733,831,,disrupts,,Capsaicin,,,,breast neoplasm,,,,, -9869751,832,,disrupts,,Capsaicin,,,,Cough,,,,, -8160008,833,,disrupts,,Capsaicin,,,,Pruritus,,,,, -25438980,834,,prevents,,Capsaicin,,,,brain injury,,,,, -20404597,835,,prevents,,Capsaicin,,,,postherpetic neuralgia,,,,, -17168513,836,,prevents,,Capsaicin,,,,migraine disorder,,,,, -16978917,837,,prevents,,Capsaicin,,,,neuralgia,,,,, -15822967,838,,prevents,,Capsaicin,,,,stroke disorder,,,,, -10290168,839,,prevents,,Capsaicin,,,,Pruritus,,,,, -8608117,840,,prevents,,Capsaicin,,,,osteoarthritis,,,,, -8246280,841,,prevents,,Capsaicin,,,,Pain,,,,, -14706687,842,,predisposes,,Capsaicin,,,,Pain,,,,, -24021484,843,,causes,,Nusinersen,,,,spinal muscular atrophy,,,,, -22907909,844,,affects,,Nusinersen,,,,spinal muscular atrophy,,,,, -27681284,845,,related to,,Hyaluronic acid sodium salt,,,,alcoholic hepatitis,,,,, -26794689,846,,related to,,Hyaluronic acid sodium salt,,,,carpal tunnel syndrome,,,,, -20903427,847,,related to,,Hyaluronic acid sodium salt,,,,Skin ulcer,,,,, -18915649,848,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -18915649,849,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -15362486,850,,related to,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, -14268478,851,,related to,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, -9147590,852,,related to,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, -7458117,853,,related to,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -17074499,854,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -17074499,855,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -12401778,856,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -12401778,857,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -11319224,858,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -11319224,859,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -7287149,860,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -7699622,861,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -12146167,862,,causes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -8938037,863,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -8541022,864,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -7683831,865,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -7895314,866,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -18839068,867,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -18839068,868,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -9813251,869,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -9813251,870,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -17165364,871,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -17165364,872,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -23839601,873,,disrupts,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, -22764727,874,,disrupts,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, -7155073,875,,disrupts,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -18262848,876,,prevents,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, -11511344,877,,prevents,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -21264578,878,,predisposes,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, -11605823,879,,predisposes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -24659748,880,,related to,,Zoledronic acid,,,,osteoporosis,,,,, -18902207,881,,causes,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, -18856931,882,,causes,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, -13083414,883,,causes,,Zoledronic acid,,,,bone fracture,,,,, -21044659,884,,affects,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, -19059032,885,,affects,,Zoledronic acid,,,,bone osteosarcoma,,,,, -13892047,886,,affects,,Zoledronic acid,,,,bone fracture,,,,, -13448998,887,,affects,,Zoledronic acid,,,,osteonecrosis,,,,, -9617769,888,,affects,,Zoledronic acid,,,,osteoporosis,,,,, -24472422,889,,disrupts,,Zoledronic acid,,,,sarcoma,,,,, -20879055,890,,disrupts,,Zoledronic acid,,,,Neoplasm Metastasis,,,,, -20879053,891,,disrupts,,Zoledronic acid,,,,Pain,,,,, -13311906,892,,disrupts,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, -9617771,893,,disrupts,,Zoledronic acid,,,,bone fracture,,,,, -22662537,894,,prevents,,Zoledronic acid,,,,osteoporosis,,,,, -20148397,895,,prevents,,Zoledronic acid,,,,osteonecrosis,,,,, -13621414,896,,prevents,,Zoledronic acid,,,,bone fracture,,,,, -12127006,897,,prevents,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, -20851623,898,,predisposes,,Zoledronic acid,,,,bone fracture,,,,, -15272127,899,,predisposes,,Zoledronic acid,,,,osteonecrosis,,,,, -14006582,900,,prevents,,Risedronic acid,,,,osteoporosis,,,,, -17290459,901,,affects,,IBANDRONIC ACID,,,,osteonecrosis,,,,, -9797983,902,,affects,,IBANDRONIC ACID,,,,Neoplasm Metastasis,,,,, -15290649,903,,prevents,,IBANDRONIC ACID,,,,bone disorder,,,,, -13697992,904,,prevents,,IBANDRONIC ACID,,,,Pain,,,,, -10307139,905,,prevents,,IBANDRONIC ACID,,,,postmenopausal osteoporosis,,,,, -10028971,906,,prevents,,IBANDRONIC ACID,,,,osteoporosis,,,,, -18363632,907,,predisposes,,IBANDRONIC ACID,,,,Abdominal pain,,,,, -9434475,908,,predisposes,,IBANDRONIC ACID,,,,osteoporosis,,,,, -17514758,909,,related to,,Alendronic acid,,,,osteoarthritis,,,,, -14283477,910,,related to,,Alendronic acid,,,,osteoporosis,,,,, -11575454,911,,related to,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -14254304,912,,causes,,Alendronic acid,,,,asthma,,,,, -14049757,913,,causes,,Alendronic acid,,,,osteoporosis,,,,, -11710947,914,,causes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -25124892,915,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -24296937,916,,affects,,Alendronic acid,,,,bone disorder,,,,, -17701514,917,,affects,,Alendronic acid,,,,osteoarthritis,,,,, -14769549,918,,affects,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -12316243,919,,affects,,Alendronic acid,,,,osteoporosis,,,,, -12136907,920,,affects,,Alendronic acid,,,,periodontitis,,,,, -8809813,921,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -22627610,922,,disrupts,,Alendronic acid,,,,aortic valve stenosis,,,,, -17047070,923,,disrupts,,Alendronic acid,,,,prostate cancer,,,,, -9109277,924,,disrupts,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -8466156,925,,disrupts,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -24628288,926,,prevents,,Alendronic acid,,,,osteoarthritis,,,,, -15290647,927,,prevents,,Alendronic acid,,,,bone disorder,,,,, -7495571,928,,prevents,,Alendronic acid,,,,osteoporosis,,,,, -7314446,929,,prevents,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -7150371,930,,prevents,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -25381093,931,,predisposes,,Alendronic acid,,,,osteoporosis,,,,, -22975353,932,,predisposes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -12652815,933,,related to,,Pamidronic acid,,,,osteoporosis,,,,, -7541169,934,,related to,,Pamidronic acid,,,,plasma cell myeloma,,,,, -12040766,935,,affects,,Pamidronic acid,,,,plasma cell myeloma,,,,, -10860757,936,,affects,,Pamidronic acid,,,,osteoporosis,,,,, -9170219,937,,prevents,,Pamidronic acid,,,,osteoporosis,,,,, -9315699,938,,prevents,,Octyl methoxycinnamate,,,,sunburn,,,,, -10529058,939,,coexists with,,4-Aminobenzoic acid,,,,Procaine,,,,, -25771688,940,,causes,,Nitrazepam,,,,epilepsy,,,,, -19206956,941,,affects,,Nitrazepam,,,,depressive disorder,,,,, -25737609,942,,disrupts,,Nitrazepam,,,,epilepsy,,,,, -7322742,943,,prevents,,Nitrazepam,,,,epilepsy,,,,, -25779340,944,,causes,,Flurazepam,,,,depressive disorder,,,,, -19092155,945,,causes,,Triazolam,,,,depressive disorder,,,,, -16852864,946,,causes,,Triazolam,,,,insomnia,,,,, -27224077,947,,affects,,Triazolam,,,,insomnia,,,,, -15159227,948,,disrupts,,Triazolam,,,,anxiety,,,,, -24702695,949,,related to,,Midazolam,,,,delirium,,,,, -16327495,950,,related to,,Midazolam,,,,obesity disorder,,,,, -17503618,951,,causes,,Midazolam,,,,Nausea,,,,, -13087342,952,,causes,,Midazolam,,,,status epilepticus,,,,, -12880145,953,,causes,,Midazolam,,,,delirium,,,,, -12134398,954,,causes,,Midazolam,,,,brain injury,,,,, -11162624,955,,causes,,Midazolam,,,,Pain,,,,, -10221339,956,,causes,,Midazolam,,,,injury,,,,, -10197463,957,,causes,,Midazolam,,,,epilepsy,,,,, -7739374,958,,causes,,Midazolam,,,,hypotensive disorder,,,,, -7211473,959,,causes,,Midazolam,,,,depressive disorder,,,,, -7104276,960,,causes,,Midazolam,,,,dissociative amnesia,,,,, -27271852,961,,affects,,Midazolam,,,,Pruritus,,,,, -26121850,962,,affects,,Midazolam,,,,Pain,,,,, -25522494,963,,affects,,Midazolam,,,,anxiety,,,,, -22514965,964,,affects,,Midazolam,,,,anxiety,,,,, -22203290,965,,affects,,Midazolam,,,,post-traumatic stress disorder,,,,, -21411467,966,,affects,,Midazolam,,,,Suicidal ideation,,,,, -20820424,967,,affects,,Midazolam,,,,injury,,,,, -20230773,968,,affects,,Midazolam,,,,hypotensive disorder,,,,, -19683992,969,,affects,,Midazolam,,,,injury,,,,, -18986257,970,,affects,,Midazolam,,,,neoplasm,,,,, -18893940,971,,affects,,Midazolam,,,,hypertensive disorder,,,,, -18670184,972,,affects,,Midazolam,,,,hypotensive disorder,,,,, -18644607,973,,affects,,Midazolam,,,,neuralgia,,,,, -18331473,974,,affects,,Midazolam,,,,status epilepticus,,,,, -17655582,975,,affects,,Midazolam,,,,Cough,,,,, -12605496,976,,affects,,Midazolam,,,,dissociative amnesia,,,,, -12154940,977,,affects,,Midazolam,,,,Nausea,,,,, -11981571,978,,affects,,Midazolam,,,,delirium,,,,, -8867560,979,,affects,,Midazolam,,,,Pain,,,,, -8871799,980,,affects,,Midazolam,,,,hypotensive disorder,,,,, -8701804,981,,affects,,Midazolam,,,,epilepsy,,,,, -8569605,982,,affects,,Midazolam,,,,brain injury,,,,, -7116661,983,,affects,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, -20025306,984,,disrupts,,Midazolam,,,,Pruritus,,,,, -18424847,985,,disrupts,,Midazolam,,,,status epilepticus,,,,, -16150704,986,,disrupts,,Midazolam,,,,Cough,,,,, -14733481,987,,disrupts,,Midazolam,,,,neuralgia,,,,, -13861580,988,,disrupts,,Midazolam,,,,Pain,,,,, -9443524,989,,disrupts,,Midazolam,,,,epilepsy,,,,, -7819099,990,,disrupts,,Midazolam,,,,anxiety,,,,, -21663738,991,,prevents,,Midazolam,,,,anxiety,,,,, -20820423,992,,prevents,,Midazolam,,,,injury,,,,, -17322994,993,,prevents,,Midazolam,,,,Aggressive behavior,,,,, -16397367,994,,prevents,,Midazolam,,,,status epilepticus,,,,, -13467675,995,,prevents,,Midazolam,,,,Nausea,,,,, -11373548,996,,prevents,,Midazolam,,,,Cough,,,,, -11041799,997,,prevents,,Midazolam,,,,bone fracture,,,,, -9493413,998,,prevents,,Midazolam,,,,epilepsy,,,,, -8653279,999,,prevents,,Midazolam,,,,Sepsis,,,,, -8569600,1000,,prevents,,Midazolam,,,,brain injury,,,,, -8151023,1001,,prevents,,Midazolam,,,,Pain,,,,, -7116663,1002,,prevents,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, -16657523,1003,,exacerbates,,Midazolam,,,,Sepsis,,,,, -19191198,1004,,predisposes,,Midazolam,,,,dissociative amnesia,,,,, -18422952,1005,,predisposes,,Midazolam,,,,status epilepticus,,,,, -11981572,1006,,predisposes,,Midazolam,,,,delirium,,,,, -22402246,1007,,disrupts,,Brotizolam,,,,anxiety,,,,, -12312025,1008,,related to,,Ganirelix,,,,polycystic ovary syndrome,,,,, -14831488,1009,,disrupts,,Cetrorelix,,,,benign prostatic hyperplasia,,,,, -18703871,1010,,prevents,,Cetrorelix,,,,endometriosis,,,,, -18874469,1011,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -18874469,1012,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -12069194,1013,,related to,,Methoxsalen,,,,mycosis fungoides,,,,, -8610329,1014,,related to,,Methoxsalen,,,,psoriasis,,,,, -26218137,1015,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -26218137,1016,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -7172075,1017,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -7172075,1018,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -26761340,1019,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -26761340,1020,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -7782040,1021,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -12022213,1022,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -9512596,1023,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -19709381,1024,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -8674128,1025,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -8674128,1026,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -8674127,1027,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -25732039,1028,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -16826513,1029,,affects,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -9717834,1030,,related to,,Bisoprolol,,,,hypertensive disorder,,,,, -17484309,1031,,affects,,Bisoprolol,,,,Hemorrhage,,,,, -14633716,1032,,affects,,Bisoprolol,,,,hypertensive disorder,,,,, -13150765,1033,,affects,,Bisoprolol,,,,pulmonary arterial hypertension,,,,, -24626572,1034,,disrupts,,Bisoprolol,,,,Hemorrhage,,,,, -23315135,1035,,prevents,,Bisoprolol,,,,Hemorrhage,,,,, -26817035,1036,,related to,,Esmolol,,,,atrial fibrillation,,,,, -13689489,1037,,causes,,Esmolol,,,,atrial fibrillation,,,,, -20072391,1038,,affects,,Esmolol,,,,toxic shock syndrome,,,,, -19519833,1039,,affects,,Esmolol,,,,Pain,,,,, -16877299,1040,,prevents,,Esmolol,,,,Pain,,,,, -10180097,1041,,prevents,,Esmolol,,,,ischemia reperfusion injury,,,,, -9581320,1042,,prevents,,Esmolol,,,,atrial fibrillation,,,,, -18235527,1043,,related to,,Oxygen,,,,pulmonary fibrosis,,,,, -18193743,1044,,related to,,Oxygen,,,,neoplasm,,,,, -17303485,1045,,related to,,Oxygen,,,,Hypoxemia,,,,, -14116536,1046,,related to,,Oxygen,,,,Shock,,,,, -13587155,1047,,related to,,Oxygen,,,,injury,,,,, -8813011,1048,,related to,,Oxygen,,,,ischemia reperfusion injury,,,,, -21893162,1049,,causes,,Oxygen,,,,neoplasm,,,,, -19992109,1050,,causes,,Oxygen,,,,ischemia reperfusion injury,,,,, -8243272,1051,,causes,,Oxygen,,,,vascular disorder,,,,, -8114891,1052,,causes,,Oxygen,,,,injury,,,,, -7992845,1053,,causes,,Oxygen,,,,Hypoxemia,,,,, -7752235,1054,,causes,,Oxygen,,,,stroke disorder,,,,, -23272853,1055,,affects,,Oxygen,,,,neoplasm,,,,, -22206348,1056,,affects,,Oxygen,,,,neoplasm,,,,, -19397332,1057,,affects,,Oxygen,,,,Hypoxemia,,,,, -13060611,1058,,affects,,Oxygen,,,,Shock,,,,, -13638133,1059,,produces,,Oxygen,,,,Hypoxemia,,,,, -13264427,1060,,produces,,Oxygen,,,,neoplasm,,,,, -12483211,1061,,disrupts,,Oxygen,,,,Hypoxemia,,,,, -11682185,1062,,disrupts,,Oxygen,,,,neoplasm,,,,, -16806319,1063,,prevents,,Oxygen,,,,injury,,,,, -17280500,1064,,predisposes,,Oxygen,,,,injury,,,,, -7575686,1065,,subclass of,,Metoprolol,,,,O-Demethylmetoprolol,,,,, -7575685,1066,,subclass of,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -27359356,1067,,related to,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -27639377,1068,,derives from,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -26548288,1069,,physically interacts with,,Metoprolol,,,,O-Demethylmetoprolol,,,,, -21656554,1070,,physically interacts with,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -27101524,1071,,causes,,Metoprolol,,,,ventricular tachycardia,,,,, -27101519,1072,,causes,,Metoprolol,,,,ventricular fibrillation,,,,, -20648435,1073,,causes,,Metoprolol,,,,cardiac rhythm disease,,,,, -14625318,1074,,causes,,Metoprolol,,,,hypertensive disorder,,,,, -19013861,1075,,affects,,Metoprolol,,,,obesity disorder,,,,, -17630974,1076,,affects,,Metoprolol,,,,coronary artery disorder,,,,, -17630973,1077,,affects,,Metoprolol,,,,atherosclerosis,,,,, -16547648,1078,,affects,,Metoprolol,,,,myocardial infarction,,,,, -12751741,1079,,affects,,Metoprolol,,,,cardiac rhythm disease,,,,, -11341339,1080,,affects,,Metoprolol,,,,hypertensive disorder,,,,, -16802112,1081,,disrupts,,Metoprolol,,,,atrial fibrillation,,,,, -14314818,1082,,disrupts,,Metoprolol,,,,atherosclerosis,,,,, -13648308,1083,,disrupts,,Metoprolol,,,,ventricular tachycardia,,,,, -12510783,1084,,disrupts,,Metoprolol,,,,cardiac rhythm disease,,,,, -16624344,1085,,prevents,,Metoprolol,,,,cardiac rhythm disease,,,,, -13530896,1086,,prevents,,Metoprolol,,,,myocardial infarction,,,,, -13366014,1087,,prevents,,Metoprolol,,,,hypertensive disorder,,,,, -13268090,1088,,prevents,,Metoprolol,,,,ventricular fibrillation,,,,, -9428080,1089,,prevents,,Metoprolol,,,,atrial fibrillation,,,,, -7236533,1090,,prevents,,Metoprolol,,,,atherosclerosis,,,,, -22663349,1091,,predisposes,,Metoprolol,,,,atrial fibrillation,,,,, -25990864,1092,,affects,,Acebutolol,,,,hypertensive disorder,,,,, -25995365,1093,,prevents,,Acebutolol,,,,hypertensive disorder,,,,, -24856753,1094,,affects,,Pretomanid,,,,multidrug-resistant tuberculosis,,,,, -17848125,1095,,related to,,Nitrogen,,,,chronic obstructive pulmonary disease,,,,, -15192685,1096,,related to,,Nitrogen,,,,ischemia reperfusion injury,,,,, -10505101,1097,,related to,,Nitrogen,,,,burn,,,,, -10425490,1098,,related to,,Nitrogen,,,,cystic fibrosis,,,,, -16934805,1099,,causes,,Nitrogen,,,,ischemia reperfusion injury,,,,, -13030867,1100,,affects,,Nitrogen,,,,ischemia reperfusion injury,,,,, -9020164,1101,,affects,,Nitrogen,,,,severe acute respiratory syndrome,,,,, -17493096,1102,,predisposes,,Nitrogen,,,,ischemia reperfusion injury,,,,, -25313239,1103,,related to,,Helium,,,,status asthmaticus,,,,, -12274245,1104,,related to,,Helium,,,,chronic obstructive pulmonary disease,,,,, -15248421,1105,,related to,,Carbon Dioxide,,,,Pain,,,,, -11844945,1106,,related to,,Carbon Dioxide,,,,sleep apnea syndrome,,,,, -10575797,1107,,related to,,Carbon Dioxide,,,,respiratory failure,,,,, -7620110,1108,,related to,,Carbon Dioxide,,,,panic disorder,,,,, -16671036,1109,,causes,,Carbon Dioxide,,,,panic disorder,,,,, -11038318,1110,,causes,,Carbon Dioxide,,,,respiratory failure,,,,, -20071308,1111,,affects,,Carbon Dioxide,,,,Pain,,,,, -15771768,1112,,affects,,Carbon Dioxide,,,,Pain,,,,, -15385933,1113,,affects,,Carbon Dioxide,,,,panic disorder,,,,, -14460813,1114,,affects,,Carbon Dioxide,,,,respiratory failure,,,,, -15294247,1115,,produces,,Carbon Dioxide,,,,respiratory failure,,,,, -11946282,1116,,disrupts,,Carbon Dioxide,,,,Pain,,,,, -17126447,1117,,predisposes,,Carbon Dioxide,,,,Pain,,,,, -11404382,1118,,predisposes,,Carbon Dioxide,,,,panic disorder,,,,, -7432027,1119,,predisposes,,Carbon Dioxide,,,,respiratory failure,,,,, -24776228,1120,,causes,,Ethambutol,,,,tuberculosis,,,,, -25946331,1121,,affects,,Ethambutol,,,,tuberculosis,,,,, -24875144,1122,,affects,,Ethambutol,,,,pulmonary tuberculosis,,,,, -25597027,1123,,disrupts,,Ethambutol,,,,tuberculosis,,,,, -18704735,1124,,prevents,,Ethambutol,,,,tuberculosis,,,,, -14472959,1125,,affects,,Pyrazinamide,,,,pulmonary tuberculosis,,,,, -10149898,1126,,affects,,Pyrazinamide,,,,tuberculosis,,,,, -8080030,1127,,prevents,,Pyrazinamide,,,,tuberculosis,,,,, -27556045,1128,,predisposes,,Pyrazinamide,,,,tuberculosis,,,,, -26376727,1129,,related to,,Androstanolone,,,,hypogonadism,,,,, -22807780,1130,,affects,,Androstanolone,,,,hypogonadism,,,,, -7261548,1131,,related to,,Nebivolol,,,,essential hypertension,,,,, -10251853,1132,,affects,,Nebivolol,,,,hypertensive disorder,,,,, -20026875,1133,,prevents,,Nebivolol,,,,cardiovascular disorder,,,,, -10251855,1134,,prevents,,Nebivolol,,,,hypertensive disorder,,,,, -11558481,1135,,exacerbates,,Nebivolol,,,,hypertensive disorder,,,,, -17527026,1136,,related to,,Landiolol,,,,atrial fibrillation,,,,, -14267268,1137,,affects,,Landiolol,,,,atrial fibrillation,,,,, -16074351,1138,,disrupts,,Landiolol,,,,atrial fibrillation,,,,, -21882778,1139,,prevents,,Landiolol,,,,cardiac rhythm disease,,,,, -14873276,1140,,prevents,,Landiolol,,,,atrial fibrillation,,,,, -20190145,1141,,predisposes,,Landiolol,,,,atrial fibrillation,,,,, -26530979,1142,,related to,,Oxandrolone,,,,nutritional disorder,,,,, -17138340,1143,,related to,,Oxandrolone,,,,Fanconi anemia,,,,, -12117784,1144,,related to,,Oxandrolone,,,,Turner syndrome,,,,, -11269262,1145,,related to,,Oxandrolone,,,,burn,,,,, -7561027,1146,,causes,,Cefepime,,,,toxic shock syndrome,,,,, -19437692,1147,,affects,,Cefepime,,,,bacterial infectious disease,,,,, -17947468,1148,,affects,,Cefepime,,,,infectious disease,,,,, -19800344,1149,,disrupts,,Cefepime,,,,infectious disease,,,,, -26336145,1150,,related to,,Hydrocortisone butyrate,,,,"dermatitis, atopic",,,,, -26243703,1151,,related to,,Hydrocortisone butyrate,,,,skin disorder,,,,, -25968096,1152,,related to,,Hydrocortisone butyrate,,,,psoriasis,,,,, -17603464,1153,,disrupts,,Hydrocortisone butyrate,,,,psoriasis,,,,, -9729745,1154,,related to,,Adapalene,,,,acne,,,,, -8571018,1155,,physically interacts with,,Adapalene,,,,Retinoic Acid Receptor,,,,, -13523825,1156,,related to,,Retinol,,,,eye disorder,,,,, -11015290,1157,,related to,,Retinol,,,,tuberculosis,,,,, -10457909,1158,,related to,,Retinol,,,,acne,,,,, -8518043,1159,,related to,,Retinol,,,,malaria,,,,, -8137103,1160,,related to,,Retinol,,,,vitamin A deficiency,,,,, -7807614,1161,,related to,,Retinol,,,,retinitis pigmentosa,,,,, -9304322,1162,,causes,,Retinol,,,,malaria,,,,, -27090494,1163,,affects,,Retinol,,,,diarrheal disease,,,,, -21959378,1164,,affects,,Retinol,,,,nutritional disorder,,,,, -17401879,1165,,affects,,Retinol,,,,tuberculosis,,,,, -17082512,1166,,affects,,Retinol,,,,acne,,,,, -12962972,1167,,affects,,Retinol,,,,eye disorder,,,,, -12534891,1168,,affects,,Retinol,,,,vitamin A deficiency,,,,, -11508263,1169,,affects,,Retinol,,,,diarrheal disease,,,,, -10941106,1170,,affects,,Retinol,,,,vitamin A deficiency,,,,, -22325993,1171,,produces,,Retinol,,,,Infection,,,,, -23772860,1172,,disrupts,,Retinol,,,,vitamin A deficiency,,,,, -12105339,1173,,disrupts,,Retinol,,,,diarrheal disease,,,,, -24823924,1174,,prevents,,Retinol,,,,Infection,,,,, -17332605,1175,,prevents,,Retinol,,,,malaria,,,,, -11445573,1176,,prevents,,Retinol,,,,nutritional disorder,,,,, -8153477,1177,,prevents,,Retinol,,,,diarrheal disease,,,,, -23860384,1178,,predisposes,,Retinol,,,,nutritional disorder,,,,, -19923430,1179,,predisposes,,Retinol,,,,malaria,,,,, -16391363,1180,,predisposes,,Retinol,,,,tuberculosis,,,,, -15050082,1181,,predisposes,,Retinol,,,,diarrheal disease,,,,, -9744244,1182,,predisposes,,Retinol,,,,vitamin A deficiency,,,,, -18962170,1183,,related to,,Isotretinoin,,,,neuroblastoma,,,,, -16229483,1184,,related to,,Isotretinoin,,,,brain cancer,,,,, -15225681,1185,,related to,,Isotretinoin,,,,acne,,,,, -14091563,1186,,related to,,Isotretinoin,,,,myelodysplastic syndrome,,,,, -9061344,1187,,related to,,Isotretinoin,,,,renal cell carcinoma,,,,, -11768316,1188,,physically interacts with,,Isotretinoin,,,,Retinoic Acid Receptor,,,,, -21199868,1189,,causes,,Isotretinoin,,,,neuroblastoma,,,,, -19803622,1190,,causes,,Isotretinoin,,,,acne,,,,, -19310397,1191,,causes,,Isotretinoin,,,,breast neoplasm,,,,, -13522698,1192,,causes,,Isotretinoin,,,,neoplasm,,,,, -23934527,1193,,affects,,Isotretinoin,,,,neoplasm,,,,, -20382078,1194,,affects,,Isotretinoin,,,,neuroblastoma,,,,, -15927367,1195,,affects,,Isotretinoin,,,,rosacea,,,,, -15330626,1196,,affects,,Isotretinoin,,,,acne,,,,, -11212975,1197,,affects,,Isotretinoin,,,,neoplasm,,,,, -9764204,1198,,affects,,Isotretinoin,,,,acne,,,,, -21476432,1199,,disrupts,,Isotretinoin,,,,neuroblastoma,,,,, -14724193,1200,,disrupts,,Isotretinoin,,,,neoplasm,,,,, -14863864,1201,,prevents,,Isotretinoin,,,,acne,,,,, -8312321,1202,,prevents,,Isotretinoin,,,,neoplasm,,,,, -15444114,1203,,exacerbates,,Isotretinoin,,,,ichthyosis,,,,, -15310461,1204,,predisposes,,Isotretinoin,,,,acne,,,,, -24593446,1205,,affects,,Trifarotene,,,,acne,,,,, -21448312,1206,,affects,,Atazanavir,,,,AIDS,,,,, -24947472,1207,,disrupts,,Atazanavir,,,,HIV infectious disease,,,,, -13198660,1208,,disrupts,,Atazanavir,,,,AIDS,,,,, -20253995,1209,,prevents,,Atazanavir,,,,AIDS,,,,, -8134603,1210,,affects,,Saquinavir,,,,HIV infectious disease,,,,, -16320598,1211,,disrupts,,Saquinavir,,,,viral infectious disease,,,,, -13198658,1212,,disrupts,,Saquinavir,,,,AIDS,,,,, -17107608,1213,,prevents,,Saquinavir,,,,HIV infectious disease,,,,, -12560548,1214,,prevents,,Indinavir,,,,viral infectious disease,,,,, -15113750,1215,,related to,,Ritonavir,,,,AIDS,,,,, -7566746,1216,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -7566746,1217,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -15583404,1218,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -15583404,1219,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -11500913,1220,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -8329957,1221,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -8452370,1222,,causes,,Ritonavir,,,,AIDS,,,,, -21492333,1223,,affects,,Ritonavir,,,,neoplasm,,,,, -12140603,1224,,affects,,Ritonavir,,,,Insulin resistance,,,,, -9520105,1225,,affects,,Ritonavir,,,,HIV infectious disease,,,,, -7566745,1226,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -15873481,1227,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -21820102,1228,,disrupts,,Ritonavir,,,,Coronavinae infectious disease,,,,, -15656958,1229,,disrupts,,Ritonavir,,,,HIV infectious disease,,,,, -9520113,1230,,disrupts,,Ritonavir,,,,neoplasm,,,,, -22737012,1231,,prevents,,Ritonavir,,,,neoplasm,,,,, -10934319,1232,,prevents,,Ritonavir,,,,Kaposi's sarcoma,,,,, -12915909,1233,,causes,,Nelfinavir,,,,diarrheal disease,,,,, -19184628,1234,,affects,,Nelfinavir,,,,neoplasm,,,,, -16087478,1235,,affects,,Nelfinavir,,,,plasma cell myeloma,,,,, -11272488,1236,,affects,,Nelfinavir,,,,diarrheal disease,,,,, -10940786,1237,,affects,,Thiopental,,,,brain injury,,,,, -7790675,1238,,prevents,,Thiopental,,,,brain injury,,,,, -26262897,1239,,causes,,Pentobarbital,,,,insomnia,,,,, -25778415,1240,,affects,,Pentobarbital,,,,insomnia,,,,, -13642757,1241,,disrupts,,Pentobarbital,,,,status epilepticus,,,,, -23761012,1242,,prevents,,Amobarbital,,,,osteoarthritis,,,,, -26983984,1243,,causes,,Moxisylyte,,,,erectile dysfunction,,,,, -26385811,1244,,prevents,,Mepyramine,,,,allergic disease,,,,, -27140633,1245,,subclass of,,Promethazine,,,,Promethazine sulfoxide,,,,, -19124534,1246,,related to,,Promethazine,,,,Vomiting,,,,, -26252918,1247,,causes,,Promethazine,,,,Vomiting,,,,, -8157500,1248,,causes,,Promethazine,,,,depressive disorder,,,,, -19547748,1249,,affects,,Promethazine,,,,Vomiting,,,,, -12404928,1250,,affects,,Promethazine,,,,Pruritus,,,,, -10742218,1251,,affects,,Promethazine,,,,Nausea,,,,, -10228295,1252,,affects,,Promethazine,,,,central nervous system origin vertigo,,,,, -7912966,1253,,affects,,Promethazine,,,,Vomiting,,,,, -13616931,1254,,disrupts,,Promethazine,,,,Nausea,,,,, -17497020,1255,,prevents,,Promethazine,,,,central nervous system origin vertigo,,,,, -11541778,1256,,prevents,,Promethazine,,,,Pruritus,,,,, -7912965,1257,,prevents,,Promethazine,,,,Vomiting,,,,, -7912964,1258,,prevents,,Promethazine,,,,Nausea,,,,, -25750000,1259,,causes,,Clemastine,,,,urticaria,,,,, -25747466,1260,,affects,,Clemastine,,,,urticaria,,,,, -19433677,1261,,affects,,Clemastine,,,,Pruritus,,,,, -25634655,1262,,disrupts,,Clemastine,,,,urticaria,,,,, -24612586,1263,,prevents,,Clemastine,,,,urticaria,,,,, -17916924,1264,,prevents,,Clemastine,,,,dermatitis,,,,, -24699384,1265,,predisposes,,Clemastine,,,,allergic disease,,,,, -25081855,1266,,affects,,Tiapride,,,,Dopamine D2 Receptor,,,,, -19553406,1267,,causes,,Amisulpride,,,,schizophrenia,,,,, -9337142,1268,,causes,,Amisulpride,,,,psychotic disorder,,,,, -24415555,1269,,affects,,Amisulpride,,,,depressive disorder,,,,, -8493076,1270,,affects,,Amisulpride,,,,schizophrenia,,,,, -20532376,1271,,prevents,,Amisulpride,,,,Postoperative Nausea and Vomiting,,,,, -19821343,1272,,prevents,,Amisulpride,,,,Nausea,,,,, -11149280,1273,,physically interacts with,,Remoxipride,,,,Dopamine D2 Receptor,,,,, -9174370,1274,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, -24158881,1275,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, -20394421,1276,,affects,,Levosulpiride,,,,Dopamine D2 Receptor,,,,, -26880772,1277,,related to,,Nitroglycerin,,,,coronary artery disorder,,,,, -26139329,1278,,related to,,Nitroglycerin,,,,hypertensive disorder,,,,, -21173297,1279,,related to,,Nitroglycerin,,,,injury,,,,, -26585664,1280,,causes,,Nitroglycerin,,,,Raynaud disease,,,,, -26278376,1281,,causes,,Nitroglycerin,,,,Angina pectoris,,,,, -26148974,1282,,causes,,Nitroglycerin,,,,myocardial infarction,,,,, -15949436,1283,,causes,,Nitroglycerin,,,,injury,,,,, -15624022,1284,,causes,,Nitroglycerin,,,,Inflammation,,,,, -14985558,1285,,causes,,Nitroglycerin,,,,hypertensive disorder,,,,, -8402702,1286,,causes,,Nitroglycerin,,,,Pain,,,,, -7629693,1287,,causes,,Nitroglycerin,,,,hypotensive disorder,,,,, -26786108,1288,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, -26278652,1289,,affects,,Nitroglycerin,,,,hypotensive disorder,,,,, -25994904,1290,,affects,,Nitroglycerin,,,,Raynaud disease,,,,, -25747829,1291,,affects,,Nitroglycerin,,,,erectile dysfunction,,,,, -25260538,1292,,affects,,Nitroglycerin,,,,Muscle spasm,,,,, -23178151,1293,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, -20885558,1294,,affects,,Nitroglycerin,,,,injury,,,,, -18491008,1295,,affects,,Nitroglycerin,,,,Hot flashes,,,,, -14421188,1296,,affects,,Nitroglycerin,,,,Angina pectoris,,,,, -13478654,1297,,affects,,Nitroglycerin,,,,osteoporosis,,,,, -11707783,1298,,affects,,Nitroglycerin,,,,Pain,,,,, -11174035,1299,,affects,,Nitroglycerin,,,,hypertensive disorder,,,,, -10595566,1300,,affects,,Nitroglycerin,,,,stroke disorder,,,,, -8601510,1301,,affects,,Nitroglycerin,,,,myocardial ischemia,,,,, -8521770,1302,,affects,,Nitroglycerin,,,,phlebitis,,,,, -8049127,1303,,affects,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, -26813951,1304,,disrupts,,Nitroglycerin,,,,myocardial ischemia,,,,, -26590847,1305,,disrupts,,Nitroglycerin,,,,hypertensive disorder,,,,, -24386334,1306,,disrupts,,Nitroglycerin,,,,phlebitis,,,,, -19274234,1307,,disrupts,,Nitroglycerin,,,,injury,,,,, -10081147,1308,,disrupts,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, -9796564,1309,,disrupts,,Nitroglycerin,,,,Pain,,,,, -25569906,1310,,prevents,,Nitroglycerin,,,,phlebitis,,,,, -21983895,1311,,prevents,,Nitroglycerin,,,,Muscle spasm,,,,, -20473117,1312,,prevents,,Nitroglycerin,,,,Inflammation,,,,, -18491009,1313,,prevents,,Nitroglycerin,,,,Hot flashes,,,,, -17804368,1314,,prevents,,Nitroglycerin,,,,hypertensive disorder,,,,, -11496690,1315,,prevents,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, -10695579,1316,,prevents,,Nitroglycerin,,,,Angina pectoris,,,,, -10573276,1317,,prevents,,Nitroglycerin,,,,myocardial infarction,,,,, -9096899,1318,,prevents,,Nitroglycerin,,,,Pain,,,,, -9057729,1319,,prevents,,Nitroglycerin,,,,Shock,,,,, -8235862,1320,,prevents,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, -7713034,1321,,prevents,,Nitroglycerin,,,,injury,,,,, -13750741,1322,,exacerbates,,Nitroglycerin,,,,myocardial ischemia,,,,, -20483551,1323,,predisposes,,Nitroglycerin,,,,myocardial ischemia,,,,, -9897513,1324,,predisposes,,Nitroglycerin,,,,Angina pectoris,,,,, -20924645,1325,,related to,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, -10616906,1326,,related to,,Isosorbide dinitrate,,,,Angina pectoris,,,,, -9112334,1327,,related to,,Isosorbide dinitrate,,,,coronary artery disorder,,,,, -26334868,1328,,affects,,Isosorbide dinitrate,,,,Angina pectoris,,,,, -10884689,1329,,affects,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, -9112335,1330,,prevents,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, -17782283,1331,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, -7084056,1332,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, -25690684,1333,,causes,,Sulpiride,,,,depressive disorder,,,,, -26343015,1334,,affects,,Sulpiride,,,,schizophrenia,,,,, -23882267,1335,,affects,,Sulpiride,,,,anxiety,,,,, -8960439,1336,,affects,,Sulpiride,,,,depressive disorder,,,,, -8364166,1337,,affects,,Sulpiride,,,,Dopamine D2 Receptor,,,,, -7538297,1338,,affects,,Sulpiride,,,,depressive disorder,,,,, -25756981,1339,,disrupts,,Sulpiride,,,,depressive disorder,,,,, -8859505,1340,,disrupts,,Sulpiride,,,,anxiety,,,,, -26753868,1341,,causes,,Isosorbide mononitrate,,,,Angina pectoris,,,,, -15856723,1342,,affects,,Isosorbide mononitrate,,,,Angina pectoris,,,,, -24979081,1343,,prevents,,Isosorbide mononitrate,,,,vascular disorder,,,,, -22319748,1344,,prevents,,Isosorbide mononitrate,,,,Angina pectoris,,,,, -23203614,1345,,related to,,Ribociclib,,,,squamous cell carcinoma,,,,, -23890460,1346,,related to,,Abemaciclib,,,,non-small cell lung carcinoma,,,,, -24133672,1347,,affects,,Abemaciclib,,,,neoplasm,,,,, -23820208,1348,,disrupts,,Abemaciclib,,,,neoplasm,,,,, -7114439,1349,,subclass of,,Sodium Chloride,,,,Electrolytes,,,,, -27178225,1350,,related to,,Sodium Chloride,,,,hypoglycemia,,,,, -26906663,1351,,related to,,Sodium Chloride,,,,ventricular septal defect,,,,, -26538206,1352,,related to,,Sodium Chloride,,,,papilloma,,,,, -26529472,1353,,related to,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, -26267091,1354,,related to,,Sodium Chloride,,,,Sepsis,,,,, -26209731,1355,,related to,,Sodium Chloride,,,,cataract,,,,, -25917183,1356,,related to,,Sodium Chloride,,,,Hypoxemia,,,,, -20673450,1357,,related to,,Sodium Chloride,,,,Alzheimer disease,,,,, -20617514,1358,,related to,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, -20321366,1359,,related to,,Sodium Chloride,,,,type 1 diabetes mellitus,,,,, -19962817,1360,,related to,,Sodium Chloride,,,,Inflammation,,,,, -19891172,1361,,related to,,Sodium Chloride,,,,acute lung injury,,,,, -19636264,1362,,related to,,Sodium Chloride,,,,ischemic disease,,,,, -19577743,1363,,related to,,Sodium Chloride,,,,spinal cord injury,,,,, -19497082,1364,,related to,,Sodium Chloride,,,,primary ciliary dyskinesia,,,,, -18975700,1365,,related to,,Sodium Chloride,,,,bacterial infectious disease,,,,, -18966398,1366,,related to,,Sodium Chloride,,,,osteoarthritis,,,,, -18860303,1367,,related to,,Sodium Chloride,,,,bone fracture,,,,, -18738706,1368,,related to,,Sodium Chloride,,,,toxic shock syndrome,,,,, -18679247,1369,,related to,,Sodium Chloride,,,,Electrolytes,,,,, -18617363,1370,,related to,,Sodium Chloride,,,,iron deficiency anemia,,,,, -18287282,1371,,related to,,Sodium Chloride,,,,Pruritus,,,,, -17603340,1372,,related to,,Sodium Chloride,,,,brain injury,,,,, -17533385,1373,,related to,,Sodium Chloride,,,,myocardial infarction,,,,, -17525035,1374,,related to,,Sodium Chloride,,,,coronary artery disorder,,,,, -17213013,1375,,related to,,Sodium Chloride,,,,hepatocellular carcinoma,,,,, -17202845,1376,,related to,,Sodium Chloride,,,,Parkinson disease,,,,, -16886803,1377,,related to,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -16594665,1378,,related to,,Sodium Chloride,,,,Pain,,,,, -16433967,1379,,related to,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, -15412515,1380,,related to,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, -14710472,1381,,related to,,Sodium Chloride,,,,bronchiolitis,,,,, -14037713,1382,,related to,,Sodium Chloride,,,,ventricular tachycardia,,,,, -13928740,1383,,related to,,Sodium Chloride,,,,pulmonary edema,,,,, -13375642,1384,,related to,,Sodium Chloride,,,,Insulin resistance,,,,, -13343201,1385,,related to,,Sodium Chloride,,,,Hypernatremia,,,,, -13277977,1386,,related to,,Sodium Chloride,,,,diabetic ketoacidosis,,,,, -11905993,1387,,related to,,Sodium Chloride,,,,depressive disorder,,,,, -11014479,1388,,related to,,Sodium Chloride,,,,glaucoma,,,,, -10966302,1389,,related to,,Sodium Chloride,,,,malaria,,,,, -10739226,1390,,related to,,Sodium Chloride,,,,heart disorder,,,,, -10689901,1391,,related to,,Sodium Chloride,,,,diabetes mellitus,,,,, -10566407,1392,,related to,,Sodium Chloride,,,,brain cancer,,,,, -10531148,1393,,related to,,Sodium Chloride,,,,kidney failure,,,,, -10510273,1394,,related to,,Sodium Chloride,,,,Shock,,,,, -10504585,1395,,related to,,Sodium Chloride,,,,tuberculosis,,,,, -10502982,1396,,related to,,Sodium Chloride,,,,nutritional disorder,,,,, -10502981,1397,,related to,,Sodium Chloride,,,,cirrhosis of liver,,,,, -10487095,1398,,related to,,Sodium Chloride,,,,pneumonia,,,,, -10439781,1399,,related to,,Sodium Chloride,,,,acute kidney failure,,,,, -10433628,1400,,related to,,Sodium Chloride,,,,psoriasis,,,,, -10370762,1401,,related to,,Sodium Chloride,,,,Hypothermia,,,,, -10318383,1402,,related to,,Sodium Chloride,,,,cardiovascular disorder,,,,, -10300324,1403,,related to,,Sodium Chloride,,,,stroke disorder,,,,, -10268953,1404,,related to,,Sodium Chloride,,,,brain edema,,,,, -9985623,1405,,related to,,Sodium Chloride,,,,Nausea,,,,, -9642141,1406,,related to,,Sodium Chloride,,,,obesity disorder,,,,, -9504754,1407,,related to,,Sodium Chloride,,,,asthma,,,,, -9350794,1408,,related to,,Sodium Chloride,,,,essential hypertension,,,,, -9217528,1409,,related to,,Sodium Chloride,,,,dry eye syndrome,,,,, -8489872,1410,,related to,,Sodium Chloride,,,,injury,,,,, -8486278,1411,,related to,,Sodium Chloride,,,,cystic fibrosis,,,,, -7822303,1412,,related to,,Sodium Chloride,,,,neoplasm,,,,, -7455347,1413,,related to,,Sodium Chloride,,,,Hypovolemia,,,,, -7397406,1414,,related to,,Sodium Chloride,,,,kidney disorder,,,,, -7259411,1415,,related to,,Sodium Chloride,,,,hypertensive disorder,,,,, -19769676,1416,,related to,,Sodium Chloride,,,,Electrolytes,,,,, -18679248,1417,,close match,,Sodium Chloride,,,,Electrolytes,,,,, -7792933,1418,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, -9181325,1419,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, -27223278,1420,,derives from,,Sodium Chloride,,,,Electrolytes,,,,, -9585905,1421,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, -9585904,1422,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, -26947391,1423,,causes,,Sodium Chloride,,,,acute kidney tubular necrosis,,,,, -26813055,1424,,causes,,Sodium Chloride,,,,Dyspnea,,,,, -26651944,1425,,causes,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, -26200221,1426,,causes,,Sodium Chloride,,,,melanoma,,,,, -25963723,1427,,causes,,Sodium Chloride,,,,cardiac arrest,,,,, -24999522,1428,,causes,,Sodium Chloride,,,,Nausea,,,,, -23507574,1429,,causes,,Sodium Chloride,,,,burn,,,,, -21365055,1430,,causes,,Sodium Chloride,,,,respiratory failure,,,,, -20716492,1431,,causes,,Sodium Chloride,,,,multiple organ dysfunction syndrome,,,,, -20666627,1432,,causes,,Sodium Chloride,,,,malaria,,,,, -20168868,1433,,causes,,Sodium Chloride,,,,fibromyalgia,,,,, -19652731,1434,,causes,,Sodium Chloride,,,,Chronic pain,,,,, -19581650,1435,,causes,,Sodium Chloride,,,,neoplasm,,,,, -19527177,1436,,causes,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, -19434783,1437,,causes,,Sodium Chloride,,,,Low back pain,,,,, -19352698,1438,,causes,,Sodium Chloride,,,,bone fracture,,,,, -19268574,1439,,causes,,Sodium Chloride,,,,ulcerative colitis,,,,, -18873789,1440,,causes,,Sodium Chloride,,,,preeclampsia,,,,, -18760766,1441,,causes,,Sodium Chloride,,,,heart disorder,,,,, -18419412,1442,,causes,,Sodium Chloride,,,,infertility disorder,,,,, -18184755,1443,,causes,,Sodium Chloride,,,,intervertebral disc degenerative disorder,,,,, -18174270,1444,,causes,,Sodium Chloride,,,,asthma,,,,, -17957169,1445,,causes,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, -17846702,1446,,causes,,Sodium Chloride,,,,cardiovascular disorder,,,,, -17472790,1447,,causes,,Sodium Chloride,,,,Postoperative Complications,,,,, -17050802,1448,,causes,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, -16922792,1449,,causes,,Sodium Chloride,,,,aortic aneurysm,,,,, -16902385,1450,,causes,,Sodium Chloride,,,,Hypoxemia,,,,, -16884655,1451,,causes,,Sodium Chloride,,,,obesity disorder,,,,, -15862216,1452,,causes,,Sodium Chloride,,,,Sepsis,,,,, -15183436,1453,,causes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -14507617,1454,,causes,,Sodium Chloride,,,,brain edema,,,,, -14335740,1455,,causes,,Sodium Chloride,,,,essential hypertension,,,,, -14100671,1456,,causes,,Sodium Chloride,,,,Cough,,,,, -13899816,1457,,causes,,Sodium Chloride,,,,brain injury,,,,, -13415978,1458,,causes,,Sodium Chloride,,,,rhinitis,,,,, -13156241,1459,,causes,,Sodium Chloride,,,,allergic disease,,,,, -12922926,1460,,causes,,Sodium Chloride,,,,periodontitis,,,,, -12796728,1461,,causes,,Sodium Chloride,,,,myocardial infarction,,,,, -12757253,1462,,causes,,Sodium Chloride,,,,urticaria,,,,, -12052924,1463,,causes,,Sodium Chloride,,,,Fever,,,,, -11367442,1464,,causes,,Sodium Chloride,,,,Hypothermia,,,,, -10844905,1465,,causes,,Sodium Chloride,,,,kidney disorder,,,,, -10703852,1466,,causes,,Sodium Chloride,,,,Ascites,,,,, -10680402,1467,,causes,,Sodium Chloride,,,,kidney failure,,,,, -10468869,1468,,causes,,Sodium Chloride,,,,Hyperhidrosis,,,,, -10303736,1469,,causes,,Sodium Chloride,,,,Hemorrhage,,,,, -10216492,1470,,causes,,Sodium Chloride,,,,Insulin resistance,,,,, -9649854,1471,,causes,,Sodium Chloride,,,,Inflammation,,,,, -9417058,1472,,causes,,Sodium Chloride,,,,stroke disorder,,,,, -9370401,1473,,causes,,Sodium Chloride,,,,acute kidney failure,,,,, -9311776,1474,,causes,,Sodium Chloride,,,,hypotensive disorder,,,,, -8912328,1475,,causes,,Sodium Chloride,,,,injury,,,,, -8760965,1476,,causes,,Sodium Chloride,,,,hyperinsulinism,,,,, -8723767,1477,,causes,,Sodium Chloride,,,,Hyponatremia,,,,, -8658207,1478,,causes,,Sodium Chloride,,,,ischemic disease,,,,, -8215909,1479,,causes,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, -7966995,1480,,causes,,Sodium Chloride,,,,Shock,,,,, -7871886,1481,,causes,,Sodium Chloride,,,,Hypernatremia,,,,, -7769838,1482,,causes,,Sodium Chloride,,,,Pain,,,,, -7535626,1483,,causes,,Sodium Chloride,,,,pulmonary edema,,,,, -7170398,1484,,causes,,Sodium Chloride,,,,cataract,,,,, -7067270,1485,,causes,,Sodium Chloride,,,,hypertensive disorder,,,,, -27640062,1486,,affects,,Sodium Chloride,,,,hyperinsulinism,,,,, -27459630,1487,,affects,,Sodium Chloride,,,,ischemic disease,,,,, -26883243,1488,,affects,,Sodium Chloride,,,,pulmonary edema,,,,, -25873721,1489,,affects,,Sodium Chloride,,,,stroke disorder,,,,, -25698961,1490,,affects,,Sodium Chloride,,,,Hypovolemia,,,,, -23350231,1491,,affects,,Sodium Chloride,,,,allergic disease,,,,, -21279163,1492,,affects,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, -19916489,1493,,affects,,Sodium Chloride,,,,malaria,,,,, -19654566,1494,,affects,,Sodium Chloride,,,,Fever,,,,, -19387644,1495,,affects,,Sodium Chloride,,,,Dyspnea,,,,, -19198162,1496,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, -19068195,1497,,affects,,Sodium Chloride,,,,Pain,,,,, -18857149,1498,,affects,,Sodium Chloride,,,,injury,,,,, -18063112,1499,,affects,,Sodium Chloride,,,,myocardial infarction,,,,, -17981225,1500,,affects,,Sodium Chloride,,,,Fever,,,,, -17956116,1501,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, -17749046,1502,,affects,,Sodium Chloride,,,,asthma,,,,, -17453252,1503,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, -17320603,1504,,affects,,Sodium Chloride,,,,brain injury,,,,, -17252322,1505,,affects,,Sodium Chloride,,,,iron deficiency anemia,,,,, -17081119,1506,,affects,,Sodium Chloride,,,,cataract,,,,, -17021361,1507,,affects,,Sodium Chloride,,,,urticaria,,,,, -16829226,1508,,affects,,Sodium Chloride,,,,osteoarthritis,,,,, -16392979,1509,,affects,,Sodium Chloride,,,,Sepsis,,,,, -16339812,1510,,affects,,Sodium Chloride,,,,Inflammation,,,,, -16191401,1511,,affects,,Sodium Chloride,,,,Shock,,,,, -16150899,1512,,affects,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, -15784044,1513,,affects,,Sodium Chloride,,,,Electrolytes,,,,, -15684126,1514,,affects,,Sodium Chloride,,,,malaria,,,,, -15518572,1515,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -15358630,1516,,affects,,Sodium Chloride,,,,brain injury,,,,, -14974493,1517,,affects,,Sodium Chloride,,,,cardiovascular disorder,,,,, -14875621,1518,,affects,,Sodium Chloride,,,,Hypoxemia,,,,, -14652078,1519,,affects,,Sodium Chloride,,,,preeclampsia,,,,, -14650670,1520,,affects,,Sodium Chloride,,,,Ascites,,,,, -14454543,1521,,affects,,Sodium Chloride,,,,Inflammation,,,,, -14269847,1522,,affects,,Sodium Chloride,,,,kidney disorder,,,,, -13713189,1523,,affects,,Sodium Chloride,,,,acute lung injury,,,,, -13361928,1524,,affects,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -13091031,1525,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -12113298,1526,,affects,,Sodium Chloride,,,,diabetes mellitus,,,,, -11936868,1527,,affects,,Sodium Chloride,,,,allergic disease,,,,, -11761266,1528,,affects,,Sodium Chloride,,,,stroke disorder,,,,, -11373059,1529,,affects,,Sodium Chloride,,,,Pain,,,,, -11352407,1530,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, -10762234,1531,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, -10689150,1532,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, -10555492,1533,,affects,,Sodium Chloride,,,,nutritional disorder,,,,, -10543207,1534,,affects,,Sodium Chloride,,,,myocarditis,,,,, -10409590,1535,,affects,,Sodium Chloride,,,,essential hypertension,,,,, -10373089,1536,,affects,,Sodium Chloride,,,,Hypernatremia,,,,, -10347664,1537,,affects,,Sodium Chloride,,,,neoplasm,,,,, -10303742,1538,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, -10216887,1539,,affects,,Sodium Chloride,,,,Shock,,,,, -10038950,1540,,affects,,Sodium Chloride,,,,injury,,,,, -9833746,1541,,affects,,Sodium Chloride,,,,obesity disorder,,,,, -9701968,1542,,affects,,Sodium Chloride,,,,brain edema,,,,, -9235049,1543,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, -9211629,1544,,affects,,Sodium Chloride,,,,asthma,,,,, -8885675,1545,,affects,,Sodium Chloride,,,,Ascites,,,,, -8142503,1546,,affects,,Sodium Chloride,,,,Insulin resistance,,,,, -7538296,1547,,affects,,Sodium Chloride,,,,depressive disorder,,,,, -7487288,1548,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, -7249676,1549,,affects,,Sodium Chloride,,,,Fever,,,,, -7189372,1550,,affects,,Sodium Chloride,,,,depressive disorder,,,,, -7186849,1551,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, -7146026,1552,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, -10370500,1553,,affects,,Sodium Chloride,,,,Electrolytes,,,,, -14010559,1554,,produces,,Sodium Chloride,,,,hypertensive disorder,,,,, -25864505,1555,,disrupts,,Sodium Chloride,,,,malaria,,,,, -19817939,1556,,disrupts,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, -19569177,1557,,disrupts,,Sodium Chloride,,,,anxiety,,,,, -19347835,1558,,disrupts,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -19339201,1559,,disrupts,,Sodium Chloride,,,,Cough,,,,, -18711875,1560,,disrupts,,Sodium Chloride,,,,pulmonary edema,,,,, -18638520,1561,,disrupts,,Sodium Chloride,,,,brain edema,,,,, -18394970,1562,,disrupts,,Sodium Chloride,,,,Inflammation,,,,, -17319016,1563,,disrupts,,Sodium Chloride,,,,dental caries,,,,, -17223012,1564,,disrupts,,Sodium Chloride,,,,hypertensive disorder,,,,, -17223011,1565,,disrupts,,Sodium Chloride,,,,cardiovascular disorder,,,,, -17009512,1566,,disrupts,,Sodium Chloride,,,,allergic disease,,,,, -13585452,1567,,disrupts,,Sodium Chloride,,,,neoplasm,,,,, -12586414,1568,,disrupts,,Sodium Chloride,,,,Hypoxemia,,,,, -12214170,1569,,disrupts,,Sodium Chloride,,,,injury,,,,, -10927798,1570,,disrupts,,Sodium Chloride,,,,stroke disorder,,,,, -8273399,1571,,disrupts,,Sodium Chloride,,,,Pain,,,,, -27207716,1572,,prevents,,Sodium Chloride,,,,periodontal disorder,,,,, -27075073,1573,,prevents,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, -23771600,1574,,prevents,,Sodium Chloride,,,,sinusitis,,,,, -21279166,1575,,prevents,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, -20586429,1576,,prevents,,Sodium Chloride,,,,stroke disorder,,,,, -20472317,1577,,prevents,,Sodium Chloride,,,,myocardial infarction,,,,, -20150308,1578,,prevents,,Sodium Chloride,,,,Chronic pain,,,,, -20050861,1579,,prevents,,Sodium Chloride,,,,Dyspnea,,,,, -19622277,1580,,prevents,,Sodium Chloride,,,,Pruritus,,,,, -19347836,1581,,prevents,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -18643598,1582,,prevents,,Sodium Chloride,,,,ventricular tachycardia,,,,, -18145237,1583,,prevents,,Sodium Chloride,,,,Nausea,,,,, -17285701,1584,,prevents,,Sodium Chloride,,,,neuralgia,,,,, -17081118,1585,,prevents,,Sodium Chloride,,,,cataract,,,,, -16603496,1586,,prevents,,Sodium Chloride,,,,brain injury,,,,, -16427621,1587,,prevents,,Sodium Chloride,,,,diabetes mellitus,,,,, -16310359,1588,,prevents,,Sodium Chloride,,,,burn,,,,, -16010295,1589,,prevents,,Sodium Chloride,,,,ischemic disease,,,,, -15507954,1590,,prevents,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, -15307837,1591,,prevents,,Sodium Chloride,,,,acute lung injury,,,,, -15219283,1592,,prevents,,Sodium Chloride,,,,allergic disease,,,,, -14919203,1593,,prevents,,Sodium Chloride,,,,spinal cord injury,,,,, -14359710,1594,,prevents,,Sodium Chloride,,,,obesity disorder,,,,, -14313516,1595,,prevents,,Sodium Chloride,,,,Inflammation,,,,, -14313515,1596,,prevents,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -13297854,1597,,prevents,,Sodium Chloride,,,,kidney disorder,,,,, -12464836,1598,,prevents,,Sodium Chloride,,,,malaria,,,,, -12453134,1599,,prevents,,Sodium Chloride,,,,iron deficiency anemia,,,,, -12276610,1600,,prevents,,Sodium Chloride,,,,essential hypertension,,,,, -12092501,1601,,prevents,,Sodium Chloride,,,,hypertensive disorder,,,,, -11205687,1602,,prevents,,Sodium Chloride,,,,acute kidney failure,,,,, -10429352,1603,,prevents,,Sodium Chloride,,,,injury,,,,, -10205494,1604,,prevents,,Sodium Chloride,,,,Hypovolemia,,,,, -9628485,1605,,prevents,,Sodium Chloride,,,,anemia,,,,, -8227059,1606,,prevents,,Sodium Chloride,,,,Shock,,,,, -8196581,1607,,prevents,,Sodium Chloride,,,,dental caries,,,,, -8059428,1608,,prevents,,Sodium Chloride,,,,Pain,,,,, -22103068,1609,,exacerbates,,Sodium Chloride,,,,hypertensive disorder,,,,, -20308305,1610,,exacerbates,,Sodium Chloride,,,,Inflammation,,,,, -21816011,1611,,predisposes,,Sodium Chloride,,,,essential hypertension,,,,, -19774957,1612,,predisposes,,Sodium Chloride,,,,pulmonary edema,,,,, -18380691,1613,,predisposes,,Sodium Chloride,,,,myocardial infarction,,,,, -18041213,1614,,predisposes,,Sodium Chloride,,,,Inflammation,,,,, -16033022,1615,,predisposes,,Sodium Chloride,,,,injury,,,,, -13840593,1616,,predisposes,,Sodium Chloride,,,,allergic disease,,,,, -13808663,1617,,predisposes,,Sodium Chloride,,,,diabetes mellitus,,,,, -13731023,1618,,predisposes,,Sodium Chloride,,,,cardiovascular disorder,,,,, -12280034,1619,,predisposes,,Sodium Chloride,,,,neoplasm,,,,, -12079247,1620,,predisposes,,Sodium Chloride,,,,hypertensive disorder,,,,, -11776631,1621,,predisposes,,Sodium Chloride,,,,stroke disorder,,,,, -11266800,1622,,predisposes,,Sodium Chloride,,,,kidney disorder,,,,, -10118531,1623,,predisposes,,Sodium Chloride,,,,obesity disorder,,,,, -9111875,1624,,predisposes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -9647073,1625,,related to,,Dexpanthenol,,,,skin disorder,,,,, -26305399,1626,,affects,,Dexpanthenol,,,,Erythema,,,,, -25421467,1627,,prevents,,Dexpanthenol,,,,cheilitis,,,,, -24024712,1628,,related to,,ELTROMBOPAG,,,,autoimmune thrombocytopenic purpura,,,,, -22097814,1629,,related to,,ELTROMBOPAG,,,,acute myeloid leukemia,,,,, -22063304,1630,,related to,,ELTROMBOPAG,,,,aplastic anemia,,,,, -22063303,1631,,related to,,ELTROMBOPAG,,,,myelodysplastic syndrome,,,,, -22049758,1632,,related to,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -23835836,1633,,causes,,ELTROMBOPAG,,,,anemia,,,,, -22601227,1634,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -21709185,1635,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -22821304,1636,,prevents,,ELTROMBOPAG,,,,Hemorrhage,,,,, -22169266,1637,,prevents,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -12546229,1638,,affects,,Etamsylate,,,,Hemorrhage,,,,, -9791897,1639,,affects,,Etamsylate,,,,Hemorrhage,,,,, -22608563,1640,,prevents,,Etamsylate,,,,Hemorrhage,,,,, -26536250,1641,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -26536250,1642,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -26158944,1643,,related to,,mitomycin C,,,,adenocarcinoma,,,,, -26111339,1644,,related to,,mitomycin C,,,,squamous cell carcinoma,,,,, -26043076,1645,,related to,,mitomycin C,,,,neoplasm,,,,, -25722815,1646,,related to,,mitomycin C,,,,leukemia,,,,, -12722759,1647,,related to,,mitomycin C,,,,carcinoma,,,,, -10467532,1648,,related to,,mitomycin C,,,,non-small cell lung carcinoma,,,,, -7255625,1649,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -7255625,1650,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8689799,1651,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8689799,1652,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8030161,1653,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8030161,1654,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -7255626,1655,,physically interacts with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -25769130,1656,,causes,,mitomycin C,,,,sarcoma,,,,, -25692678,1657,,causes,,mitomycin C,,,,hepatocellular carcinoma,,,,, -20975852,1658,,causes,,mitomycin C,,,,carcinoma,,,,, -12184177,1659,,causes,,mitomycin C,,,,Corneal opacity,,,,, -11626710,1660,,causes,,mitomycin C,,,,urethral stricture,,,,, -9485346,1661,,causes,,mitomycin C,,,,neoplasm,,,,, -26017044,1662,,affects,,mitomycin C,,,,squamous cell carcinoma,,,,, -25924198,1663,,affects,,mitomycin C,,,,adenocarcinoma,,,,, -24961205,1664,,affects,,mitomycin C,,,,neoplasm,,,,, -21183193,1665,,affects,,mitomycin C,,,,transitional cell carcinoma,,,,, -20995393,1666,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, -20865956,1667,,affects,,mitomycin C,,,,pterygium,,,,, -17166086,1668,,affects,,mitomycin C,,,,mesothelioma,,,,, -15342296,1669,,affects,,mitomycin C,,,,sclerosing cholangitis,,,,, -14897135,1670,,affects,,mitomycin C,,,,Corneal opacity,,,,, -14480408,1671,,affects,,mitomycin C,,,,liver and intrahepatic bile duct neoplasm,,,,, -14435862,1672,,affects,,mitomycin C,,,,Corneal opacity,,,,, -10146530,1673,,affects,,mitomycin C,,,,open-angle glaucoma,,,,, -8885108,1674,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, -8612675,1675,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8242643,1676,,affects,,mitomycin C,,,,neoplasm,,,,, -8428809,1677,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -26926271,1678,,disrupts,,mitomycin C,,,,Neoplasm Metastasis,,,,, -21172443,1679,,disrupts,,mitomycin C,,,,urinary bladder neoplasm,,,,, -16608751,1680,,disrupts,,mitomycin C,,,,carcinoma,,,,, -12093037,1681,,disrupts,,mitomycin C,,,,neoplasm,,,,, -8920186,1682,,disrupts,,mitomycin C,,,,Corneal opacity,,,,, -22973529,1683,,prevents,,mitomycin C,,,,glaucoma,,,,, -19902018,1684,,prevents,,mitomycin C,,,,keratoconus,,,,, -19673685,1685,,prevents,,mitomycin C,,,,urethral stricture,,,,, -12959208,1686,,prevents,,mitomycin C,,,,Neoplasm Metastasis,,,,, -11642092,1687,,prevents,,mitomycin C,,,,Esophageal stenosis,,,,, -9925117,1688,,prevents,,mitomycin C,,,,neoplasm,,,,, -8410588,1689,,prevents,,mitomycin C,,,,pterygium,,,,, -7308263,1690,,prevents,,mitomycin C,,,,urinary bladder neoplasm,,,,, -20886584,1691,,predisposes,,mitomycin C,,,,neoplasm,,,,, -17638153,1692,,related to,,Cefazolin,,,,bone fracture,,,,, -20958121,1693,,causes,,Cefazolin,,,,bacterial infectious disease with sepsis,,,,, -25339548,1694,,affects,,Cefazolin,,,,obesity disorder,,,,, -27670629,1695,,prevents,,Cefazolin,,,,staphylococcal infection,,,,, -10537097,1696,,prevents,,Cefazolin,,,,bacterial infectious disease,,,,, -7415834,1697,,affects,,Famciclovir,,,,herpes zoster,,,,, -27310156,1698,,disrupts,,Famciclovir,,,,viral infectious disease,,,,, -11859744,1699,,disrupts,,Famciclovir,,,,herpes simplex infectious disease,,,,, -11859743,1700,,disrupts,,Famciclovir,,,,genital herpes,,,,, -7415831,1701,,prevents,,Famciclovir,,,,herpes zoster,,,,, -27248580,1702,,related to,,Acyclovir,,,,herpes zoster,,,,, -20916830,1703,,causes,,Acyclovir,,,,viral infectious disease,,,,, -21459205,1704,,affects,,Acyclovir,,,,herpes zoster,,,,, -17108497,1705,,affects,,Acyclovir,,,,genital herpes,,,,, -15677184,1706,,affects,,Acyclovir,,,,viral infectious disease,,,,, -9966648,1707,,affects,,Acyclovir,,,,chickenpox,,,,, -8137898,1708,,affects,,Acyclovir,,,,cytomegalovirus infection,,,,, -26100053,1709,,disrupts,,Acyclovir,,,,herpes zoster,,,,, -21196251,1710,,disrupts,,Acyclovir,,,,cytomegalovirus infection,,,,, -21045605,1711,,disrupts,,Acyclovir,,,,herpes simplex infectious disease,,,,, -13979845,1712,,disrupts,,Acyclovir,,,,HIV infectious disease,,,,, -11163493,1713,,disrupts,,Acyclovir,,,,chickenpox,,,,, -10081763,1714,,disrupts,,Acyclovir,,,,viral infectious disease,,,,, -8112053,1715,,disrupts,,Acyclovir,,,,genital herpes,,,,, -22220716,1716,,prevents,,Acyclovir,,,,chickenpox,,,,, -14453930,1717,,prevents,,Acyclovir,,,,herpes zoster,,,,, -11048138,1718,,prevents,,Acyclovir,,,,herpes labialis,,,,, -10652424,1719,,prevents,,Acyclovir,,,,viral infectious disease,,,,, -9977810,1720,,prevents,,Acyclovir,,,,genital herpes,,,,, -8973083,1721,,prevents,,Acyclovir,,,,cytomegalovirus infection,,,,, -8455850,1722,,prevents,,Acyclovir,,,,herpes simplex infectious disease,,,,, -16777411,1723,,predisposes,,Acyclovir,,,,herpes simplex infectious disease,,,,, -14602481,1724,,predisposes,,Acyclovir,,,,HIV infectious disease,,,,, -7066348,1725,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -7066348,1726,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -10786366,1727,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -10786366,1728,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -15969143,1729,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -15969143,1730,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -10765452,1731,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -8193345,1732,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -13332148,1733,,causes,,Idoxuridine,,,,viral infectious disease,,,,, -25762983,1734,,affects,,Idoxuridine,,,,viral infectious disease,,,,, -25024576,1735,,affects,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -25798138,1736,,affects,,Vidarabine,,,,herpes simplex infectious disease,,,,, -18005400,1737,,related to,,Ganciclovir,,,,AIDS,,,,, -11769089,1738,,related to,,Ganciclovir,,,,lymphoma,,,,, -7813894,1739,,causes,,Ganciclovir,,,,hepatocellular carcinoma,,,,, -21315977,1740,,affects,,Ganciclovir,,,,melanoma,,,,, -18696617,1741,,affects,,Ganciclovir,,,,viral infectious disease,,,,, -14018850,1742,,affects,,Ganciclovir,,,,graft versus host disease,,,,, -7745805,1743,,affects,,Ganciclovir,,,,hepatocellular carcinoma,,,,, -7264703,1744,,affects,,Ganciclovir,,,,retinitis,,,,, -7193112,1745,,affects,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, -27515973,1746,,disrupts,,Ganciclovir,,,,viral infectious disease,,,,, -20042666,1747,,disrupts,,Ganciclovir,,,,glioblastoma,,,,, -11829393,1748,,disrupts,,Ganciclovir,,,,cytomegalovirus infection,,,,, -9242712,1749,,disrupts,,Ganciclovir,,,,hepatocellular carcinoma,,,,, -27273103,1750,,prevents,,Ganciclovir,,,,retinitis,,,,, -14947813,1751,,prevents,,Ganciclovir,,,,viral infectious disease,,,,, -8898867,1752,,prevents,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, -7606615,1753,,prevents,,Ganciclovir,,,,cytomegalovirus infection,,,,, -26756507,1754,,affects,,Nedocromil,,,,asthma,,,,, -12807968,1755,,affects,,Nedocromil,,,,asthma,,,,, -15773495,1756,,disrupts,,Nedocromil,,,,asthma,,,,, -26602335,1757,,prevents,,Nedocromil,,,,asthma,,,,, -25857910,1758,,related to,,Flumedroxone,,,,migraine disorder,,,,, -26456255,1759,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, -26456255,1760,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, -26331358,1761,,affects,,Valrubicin,,,,Deoxyribonucleic acid,,,,, -9013591,1762,,affects,,Valrubicin,,,,neoplasm,,,,, -15048973,1763,,disrupts,,Valrubicin,,,,neoplasm,,,,, -19780799,1764,,related to,,Idarubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -19123529,1765,,related to,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, -17160344,1766,,related to,,Idarubicin,,,,myelodysplastic syndrome,,,,, -13481436,1767,,related to,,Idarubicin,,,,acute myeloid leukemia,,,,, -12261572,1768,,related to,,Idarubicin,,,,plasma cell myeloma,,,,, -10347974,1769,,related to,,Idarubicin,,,,non-Hodgkin lymphoma,,,,, -8798925,1770,,related to,,Idarubicin,,,,acute promyelocytic leukemia,,,,, -17955637,1771,,causes,,Idarubicin,,,,acute myeloid leukemia,,,,, -10037923,1772,,causes,,Idarubicin,,,,neutropenia,,,,, -27637811,1773,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, -27582612,1774,,affects,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, -27363552,1775,,affects,,Idarubicin,,,,neoplasm,,,,, -10133635,1776,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, -9755321,1777,,affects,,Idarubicin,,,,leukemia,,,,, -9560678,1778,,affects,,Idarubicin,,,,neoplasm,,,,, -9242996,1779,,affects,,Idarubicin,,,,neutropenia,,,,, -18342294,1780,,causes,,Pirarubicin,,,,neoplasm,,,,, -16182034,1781,,affects,,Pirarubicin,,,,neoplasm,,,,, -19153993,1782,,disrupts,,Pirarubicin,,,,neoplasm,,,,, -14778803,1783,,prevents,,Pirarubicin,,,,neoplasm,,,,, -20218174,1784,,subclass of,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, -25737166,1785,,related to,,Mitoxantrone,,,,lymphoma,,,,, -19961419,1786,,related to,,Mitoxantrone,,,,breast neoplasm,,,,, -14217137,1787,,related to,,Mitoxantrone,,,,mantle cell lymphoma,,,,, -13051364,1788,,related to,,Mitoxantrone,,,,multiple sclerosis,,,,, -8903075,1789,,related to,,Mitoxantrone,,,,acute myeloid leukemia,,,,, -8584278,1790,,causes,,Mitoxantrone,,,,acute myeloid leukemia,,,,, -26143277,1791,,affects,,Mitoxantrone,,,,lymphoma,,,,, -20218175,1792,,affects,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, -11986455,1793,,affects,,Mitoxantrone,,,,multiple sclerosis,,,,, -9134230,1794,,prevents,,Mitoxantrone,,,,neoplasm,,,,, -11307631,1795,,exacerbates,,Mitoxantrone,,,,multiple sclerosis,,,,, -26844498,1796,,related to,,Doxorubicin,,,,renal cell carcinoma,,,,, -26506763,1797,,related to,,Doxorubicin,,,,Kaposi's sarcoma,,,,, -26097255,1798,,related to,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -25468576,1799,,related to,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, -21586070,1800,,related to,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, -17293414,1801,,related to,,Doxorubicin,,,,neoplasm,,,,, -14824461,1802,,related to,,Doxorubicin,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -12975330,1803,,related to,,Doxorubicin,,,,"Lymphoma, AIDS-Related",,,,, -12635005,1804,,related to,,Doxorubicin,,,,neuroendocrine neoplasm,,,,, -11664648,1805,,related to,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, -8248824,1806,,related to,,Doxorubicin,,,,lymphoma,,,,, -7897058,1807,,related to,,Doxorubicin,,,,leukemia,,,,, -7111309,1808,,related to,,Doxorubicin,,,,Hodgkins lymphoma,,,,, -26198671,1809,,causes,,Doxorubicin,,,,acute myeloid leukemia,,,,, -20905498,1810,,causes,,Doxorubicin,,,,prostate cancer,,,,, -19998968,1811,,causes,,Doxorubicin,,,,Hodgkins lymphoma,,,,, -17176693,1812,,causes,,Doxorubicin,,,,B-cell neoplasm,,,,, -16306119,1813,,causes,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -14936910,1814,,causes,,Doxorubicin,,,,plasma cell myeloma,,,,, -13613509,1815,,causes,,Doxorubicin,,,,sarcoma,,,,, -12176485,1816,,causes,,Doxorubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -12086573,1817,,causes,,Doxorubicin,,,,leukemia,,,,, -11480674,1818,,causes,,Doxorubicin,,,,Neoplasm Metastasis,,,,, -11088747,1819,,causes,,Doxorubicin,,,,neoplasm,,,,, -7374660,1820,,causes,,Doxorubicin,,,,neutropenia,,,,, -25410483,1821,,affects,,Doxorubicin,,,,glioma,,,,, -25202161,1822,,affects,,Doxorubicin,,,,glioblastoma,,,,, -24066270,1823,,affects,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, -23980169,1824,,affects,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, -20976248,1825,,affects,,Doxorubicin,,,,neuroblastoma,,,,, -20526631,1826,,affects,,Doxorubicin,,,,gastric neoplasm,,,,, -20464122,1827,,affects,,Doxorubicin,,,,T-cell non-Hodgkin lymphoma,,,,, -19907850,1828,,affects,,Doxorubicin,,,,renal cell carcinoma,,,,, -18966824,1829,,affects,,Doxorubicin,,,,leiomyosarcoma,,,,, -18841320,1830,,affects,,Doxorubicin,,,,B-cell chronic lymphocytic leukemia,,,,, -17410518,1831,,affects,,Doxorubicin,,,,rhabdomyosarcoma,,,,, -17166104,1832,,affects,,Doxorubicin,,,,mesothelioma,,,,, -17156749,1833,,affects,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, -17092174,1834,,affects,,Doxorubicin,,,,glioma,,,,, -16319458,1835,,affects,,Doxorubicin,,,,sarcoma,,,,, -15641121,1836,,affects,,Doxorubicin,,,,liver and intrahepatic bile duct neoplasm,,,,, -15592048,1837,,affects,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, -15335028,1838,,affects,,Doxorubicin,,,,pancreatic ductal adenocarcinoma,,,,, -15288278,1839,,affects,,Doxorubicin,,,,mantle cell lymphoma,,,,, -15233880,1840,,affects,,Doxorubicin,,,,prostate cancer,,,,, -14862593,1841,,affects,,Doxorubicin,,,,liposarcoma,,,,, -13717435,1842,,affects,,Doxorubicin,,,,prostate cancer,,,,, -13641465,1843,,affects,,Doxorubicin,,,,Ewing sarcoma,,,,, -13641464,1844,,affects,,Doxorubicin,,,,bone osteosarcoma,,,,, -13477582,1845,,affects,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -12593977,1846,,affects,,Doxorubicin,,,,Kaposi's sarcoma,,,,, -12038917,1847,,affects,,Doxorubicin,,,,acute lymphoblastic leukemia,,,,, -11963770,1848,,affects,,Doxorubicin,,,,angiosarcoma,,,,, -11068243,1849,,affects,,Doxorubicin,,,,neutropenia,,,,, -9029101,1850,,affects,,Doxorubicin,,,,neoplasm,,,,, -7957058,1851,,affects,,Doxorubicin,,,,neoplasm,,,,, -7468708,1852,,affects,,Doxorubicin,,,,carcinoma,,,,, -7221748,1853,,affects,,Doxorubicin,,,,small cell lung carcinoma,,,,, -22415368,1854,,disrupts,,Doxorubicin,,,,glioma,,,,, -21775806,1855,,disrupts,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, -19908932,1856,,disrupts,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, -19216444,1857,,disrupts,,Doxorubicin,,,,lymphoma,,,,, -18593046,1858,,disrupts,,Doxorubicin,,,,bone osteosarcoma,,,,, -17338969,1859,,disrupts,,Doxorubicin,,,,melanoma,,,,, -15233882,1860,,disrupts,,Doxorubicin,,,,prostate cancer,,,,, -15026936,1861,,disrupts,,Doxorubicin,,,,B-cell neoplasm,,,,, -14123664,1862,,disrupts,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -11529496,1863,,disrupts,,Doxorubicin,,,,neuroblastoma,,,,, -8800155,1864,,disrupts,,Doxorubicin,,,,neoplasm,,,,, -8316270,1865,,disrupts,,Doxorubicin,,,,Neoplasm Metastasis,,,,, -24403937,1866,,prevents,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, -23195923,1867,,prevents,,Doxorubicin,,,,lung neoplasm,,,,, -22365593,1868,,prevents,,Doxorubicin,,,,leukemia,,,,, -15227703,1869,,prevents,,Doxorubicin,,,,sarcoma,,,,, -10708896,1870,,prevents,,Doxorubicin,,,,urinary bladder neoplasm,,,,, -8872024,1871,,prevents,,Doxorubicin,,,,Neoplasm Metastasis,,,,, -8737011,1872,,prevents,,Doxorubicin,,,,neutropenia,,,,, -7721507,1873,,prevents,,Doxorubicin,,,,neoplasm,,,,, -18908502,1874,,exacerbates,,Doxorubicin,,,,neoplasm,,,,, -25000938,1875,,predisposes,,Doxorubicin,,,,bone osteosarcoma,,,,, -20426915,1876,,predisposes,,Doxorubicin,,,,neoplasm,,,,, -19669792,1877,,predisposes,,Doxorubicin,,,,sarcoma,,,,, -18137816,1878,,predisposes,,Doxorubicin,,,,lymphoma,,,,, -12722667,1879,,predisposes,,Doxorubicin,,,,acute myeloid leukemia,,,,, -8803332,1880,,predisposes,,Doxorubicin,,,,kidney Wilms tumor,,,,, -7173827,1881,,predisposes,,Doxorubicin,,,,leukemia,,,,, -26966260,1882,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, -26966260,1883,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, -10565399,1884,,physically interacts with,,Iproniazid,,,,Monoamine Oxidase,,,,, -12902070,1885,,affects,,Iproniazid,,,,depressive disorder,,,,, -9833655,1886,,affects,,Iproniazid,,,,Monoamine Oxidase,,,,, -10498318,1887,,related to,,Epirubicin,,,,non-small cell lung carcinoma,,,,, -10228088,1888,,related to,,Epirubicin,,,,ovarian cancer,,,,, -10182077,1889,,related to,,Epirubicin,,,,non-Hodgkin lymphoma,,,,, -10182076,1890,,related to,,Epirubicin,,,,Hodgkins lymphoma,,,,, -8413603,1891,,related to,,Epirubicin,,,,small cell lung carcinoma,,,,, -7746533,1892,,related to,,Epirubicin,,,,castration-resistant prostate carcinoma,,,,, -26737878,1893,,physically interacts with,,Epirubicin,,,,7-Deoxydoxorubicinone,,,,, -18781215,1894,,causes,,Epirubicin,,,,neoplasm,,,,, -26736958,1895,,affects,,Epirubicin,,,,hepatocellular carcinoma,,,,, -12104701,1896,,affects,,Epirubicin,,,,neoplasm,,,,, -14784473,1897,,prevents,,Epirubicin,,,,neoplasm,,,,, -10544897,1898,,physically interacts with,,Nialamide,,,,Monoamine Oxidase,,,,, -9388429,1899,,affects,,Nialamide,,,,Monoamine Oxidase,,,,, -10646811,1900,,affects,,Isocarboxazid,,,,Monoamine Oxidase,,,,, -14451724,1901,,causes,,Valacyclovir,,,,psychotic disorder,,,,, -27205274,1902,,affects,,Valacyclovir,,,,postherpetic neuralgia,,,,, -25557382,1903,,affects,,Valacyclovir,,,,Pregnancy,,,,, -19384061,1904,,disrupts,,Valacyclovir,,,,herpes simplex infectious disease,,,,, -14963245,1905,,disrupts,,Valacyclovir,,,,herpes zoster,,,,, -10778326,1906,,disrupts,,Valacyclovir,,,,viral infectious disease,,,,, -10108851,1907,,disrupts,,Valacyclovir,,,,herpes labialis,,,,, -8112054,1908,,disrupts,,Valacyclovir,,,,genital herpes,,,,, -19368060,1909,,prevents,,Valacyclovir,,,,postherpetic neuralgia,,,,, -12346968,1910,,prevents,,Valacyclovir,,,,genital herpes,,,,, -10108849,1911,,prevents,,Valacyclovir,,,,herpes labialis,,,,, -9970234,1912,,prevents,,Valacyclovir,,,,herpes simplex infectious disease,,,,, -8018684,1913,,prevents,,Valacyclovir,,,,cytomegalovirus infection,,,,, -8899981,1914,,affects,,Cidofovir,,,,cytomegalovirus retinitis,,,,, -7346321,1915,,affects,,Cidofovir,,,,viral infectious disease,,,,, -11567412,1916,,disrupts,,Cidofovir,,,,cytomegalovirus infection,,,,, -27502123,1917,,prevents,,Cidofovir,,,,herpes simplex infectious disease,,,,, -16212718,1918,,prevents,,Cidofovir,,,,cytomegalovirus infection,,,,, -11248462,1919,,prevents,,Cidofovir,,,,viral infectious disease,,,,, -26922185,1920,,affects,,Penciclovir,,,,viral infectious disease,,,,, -22087736,1921,,affects,,Valganciclovir,,,,cytomegalovirus infection,,,,, -18756429,1922,,affects,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, -20121657,1923,,disrupts,,Valganciclovir,,,,cytomegalovirus infection,,,,, -12085189,1924,,prevents,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, -11282399,1925,,prevents,,Valganciclovir,,,,cytomegalovirus infection,,,,, -23156448,1926,,predisposes,,Valganciclovir,,,,kidney disorder,,,,, -20121656,1927,,predisposes,,Valganciclovir,,,,cytomegalovirus infection,,,,, -24607675,1928,,prevents,,Remdesivir,,,,adult acute respiratory distress syndrome,,,,, -18302878,1929,,related to,,Pixantrone,,,,Deoxyribonucleic acid,,,,, -19964229,1930,,affects,,Amrubicin,,,,small cell lung carcinoma,,,,, -15413207,1931,,disrupts,,Amrubicin,,,,neoplasm,,,,, -16523835,1932,,related to,,Sevoflurane,,,,delirium,,,,, -24969850,1933,,causes,,Sevoflurane,,,,adult acute respiratory distress syndrome,,,,, -24682900,1934,,causes,,Sevoflurane,,,,acute kidney failure,,,,, -18232524,1935,,causes,,Sevoflurane,,,,Inflammation,,,,, -17508909,1936,,causes,,Sevoflurane,,,,brain injury,,,,, -17459839,1937,,causes,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -11419059,1938,,causes,,Sevoflurane,,,,delirium,,,,, -7326848,1939,,causes,,Sevoflurane,,,,Pain,,,,, -25308865,1940,,affects,,Sevoflurane,,,,neoplasm,,,,, -25006055,1941,,affects,,Sevoflurane,,,,Pain,,,,, -21710900,1942,,affects,,Sevoflurane,,,,obesity disorder,,,,, -18602416,1943,,affects,,Sevoflurane,,,,delirium,,,,, -17685948,1944,,affects,,Sevoflurane,,,,Pain,,,,, -17508906,1945,,affects,,Sevoflurane,,,,brain injury,,,,, -13563816,1946,,affects,,Sevoflurane,,,,Inflammation,,,,, -7303814,1947,,affects,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -22571416,1948,,disrupts,,Sevoflurane,,,,myocardial infarction,,,,, -22138617,1949,,disrupts,,Sevoflurane,,,,brain injury,,,,, -19949689,1950,,disrupts,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -17977822,1951,,disrupts,,Sevoflurane,,,,Inflammation,,,,, -24348187,1952,,prevents,,Sevoflurane,,,,acute kidney failure,,,,, -24204877,1953,,prevents,,Sevoflurane,,,,neoplasm,,,,, -20028749,1954,,prevents,,Sevoflurane,,,,delirium,,,,, -19290567,1955,,prevents,,Sevoflurane,,,,Pain,,,,, -16830216,1956,,prevents,,Sevoflurane,,,,Inflammation,,,,, -11671117,1957,,prevents,,Sevoflurane,,,,brain injury,,,,, -9664903,1958,,prevents,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -18320093,1959,,predisposes,,Sevoflurane,,,,delirium,,,,, -18121347,1960,,predisposes,,Sevoflurane,,,,Inflammation,,,,, -24455592,1961,,causes,,Desflurane,,,,Postoperative Complications,,,,, -16095968,1962,,related to,,Heroin,,,,heroin dependence,,,,, -9440915,1963,,related to,,Heroin,,,,opiate dependence,,,,, -18531996,1964,,causes,,Heroin,,,,heroin dependence,,,,, -14784390,1965,,causes,,Heroin,,,,opiate dependence,,,,, -19449218,1966,,related to,,Aluminum hydroxide,,,,type 1 diabetes mellitus,,,,, -19135529,1967,,related to,,Aluminum hydroxide,,,,malaria,,,,, -18758930,1968,,related to,,Aluminum hydroxide,,,,influenza,,,,, -15398111,1969,,prevents,,Aluminum hydroxide,,,,stomatitis,,,,, -15812884,1970,,related to,,Methadone,,,,heroin dependence,,,,, -19260564,1971,,causes,,Methadone,,,,neonatal abstinence syndrome,,,,, -18130331,1972,,causes,,Methadone,,,,neuralgia,,,,, -18100345,1973,,causes,,Methadone,,,,Pain,,,,, -21405277,1974,,affects,,Methadone,,,,opiate dependence,,,,, -21075382,1975,,affects,,Methadone,,,,neoplasm,,,,, -20010980,1976,,affects,,Methadone,,,,Premature birth,,,,, -18302283,1977,,affects,,Methadone,,,,Pain,,,,, -18207522,1978,,affects,,Methadone,,,,neonatal abstinence syndrome,,,,, -18078354,1979,,affects,,Methadone,,,,cocaine dependence,,,,, -11558529,1980,,affects,,Methadone,,,,HIV infectious disease,,,,, -9289228,1981,,affects,,Methadone,,,,HIV infectious disease,,,,, -8979183,1982,,affects,,Methadone,,,,neuralgia,,,,, -16059875,1983,,disrupts,,Methadone,,,,neonatal abstinence syndrome,,,,, -10769844,1984,,disrupts,,Methadone,,,,Pain,,,,, -17766557,1985,,prevents,,Methadone,,,,hepatitis C virus infection,,,,, -15264750,1986,,prevents,,Methadone,,,,opiate dependence,,,,, -8905283,1987,,prevents,,Methadone,,,,Pain,,,,, -8022918,1988,,prevents,,Methadone,,,,neonatal abstinence syndrome,,,,, -26487110,1989,,predisposes,,Methadone,,,,HIV infectious disease,,,,, -15424591,1990,,predisposes,,Methadone,,,,neonatal abstinence syndrome,,,,, -14491460,1991,,predisposes,,Methadone,,,,Premature birth,,,,, -26386166,1992,,causes,,Levomethadyl acetate,,,,opiate dependence,,,,, -26901861,1993,,prevents,,Halofantrine,,,,malaria,,,,, -27668107,1994,,related to,,Erythropoietin,,,,HIV infectious disease,,,,, -24695634,1995,,related to,,Erythropoietin,,,,optic nerve disorder,,,,, -21186290,1996,,related to,,Erythropoietin,,,,Premature birth,,,,, -20871066,1997,,related to,,Erythropoietin,,,,necrotizing enterocolitis,,,,, -18130124,1998,,related to,,Erythropoietin,,,,mood disorder,,,,, -17186873,1999,,related to,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, -16980950,2000,,related to,,Erythropoietin,,,,acute myeloid leukemia,,,,, -16468663,2001,,related to,,Erythropoietin,,,,optic neuritis,,,,, -16173384,2002,,related to,,Erythropoietin,,,,Friedreich ataxia,,,,, -15054484,2003,,related to,,Erythropoietin,,,,breast neoplasm,,,,, -14004775,2004,,related to,,Erythropoietin,,,,malaria,,,,, -13955435,2005,,related to,,Erythropoietin,,,,chronic renal failure syndrome,,,,, -13624052,2006,,related to,,Erythropoietin,,,,stroke disorder,,,,, -13580694,2007,,related to,,Erythropoietin,,,,Fatigue,,,,, -13206114,2008,,related to,,Erythropoietin,,,,sickle cell anemia,,,,, -12496787,2009,,related to,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, -12188394,2010,,related to,,Erythropoietin,,,,Parkinson disease,,,,, -12126135,2011,,related to,,Erythropoietin,,,,spinal cord injury,,,,, -11923140,2012,,related to,,Erythropoietin,,,,acute kidney failure,,,,, -11799479,2013,,related to,,Erythropoietin,,,,myocardial infarction,,,,, -11734187,2014,,related to,,Erythropoietin,,,,multiple sclerosis,,,,, -11580074,2015,,related to,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -11529882,2016,,related to,,Erythropoietin,,,,myocardial ischemia,,,,, -11452051,2017,,related to,,Erythropoietin,,,,prostate cancer,,,,, -11316441,2018,,related to,,Erythropoietin,,,,Ischemic stroke,,,,, -11293850,2019,,related to,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, -10879812,2020,,related to,,Erythropoietin,,,,hepatitis C virus infection,,,,, -10348029,2021,,related to,,Erythropoietin,,,,neoplasm,,,,, -9392178,2022,,related to,,Erythropoietin,,,,injury,,,,, -9089666,2023,,related to,,Erythropoietin,,,,chronic myelomonocytic leukemia,,,,, -8164061,2024,,related to,,Erythropoietin,,,,myelodysplastic syndrome,,,,, -7458321,2025,,related to,,Erythropoietin,,,,brain ischemia,,,,, -7310369,2026,,related to,,Erythropoietin,,,,anemia,,,,, -7231907,2027,,related to,,Erythropoietin,,,,chronic kidney disease,,,,, -7137476,2028,,related to,,Erythropoietin,,,,kidney failure,,,,, -12479345,2029,,has part,,Erythropoietin,,,,myelodysplastic syndrome,,,,, -9398172,2030,,has part,,Erythropoietin,,,,neoplasm,,,,, -27259307,2031,,causes,,Erythropoietin,,,,acute kidney failure,,,,, -20985522,2032,,causes,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -19282478,2033,,causes,,Erythropoietin,,,,neoplasm,,,,, -19178150,2034,,causes,,Erythropoietin,,,,spinal cord injury,,,,, -18508111,2035,,causes,,Erythropoietin,,,,Parkinson disease,,,,, -16355442,2036,,causes,,Erythropoietin,,,,brain ischemia,,,,, -15387266,2037,,causes,,Erythropoietin,,,,stroke disorder,,,,, -13935957,2038,,causes,,Erythropoietin,,,,injury,,,,, -12824447,2039,,causes,,Erythropoietin,,,,chronic kidney disease,,,,, -11912976,2040,,causes,,Erythropoietin,,,,myocardial infarction,,,,, -11763164,2041,,causes,,Erythropoietin,,,,Fatigue,,,,, -9672360,2042,,causes,,Erythropoietin,,,,kidney failure,,,,, -9370139,2043,,causes,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, -8009177,2044,,causes,,Erythropoietin,,,,anemia,,,,, -26962810,2045,,affects,,Erythropoietin,,,,HIV infectious disease,,,,, -26278974,2046,,affects,,Erythropoietin,,,,sickle cell anemia,,,,, -24983690,2047,,affects,,Erythropoietin,,,,acute myeloid leukemia,,,,, -20885392,2048,,affects,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, -20610677,2049,,affects,,Erythropoietin,,,,stroke disorder,,,,, -18390137,2050,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, -18352546,2051,,affects,,Erythropoietin,,,,injury,,,,, -17607901,2052,,affects,,Erythropoietin,,,,necrotizing enterocolitis,,,,, -15862945,2053,,affects,,Erythropoietin,,,,Ischemic stroke,,,,, -15862785,2054,,affects,,Erythropoietin,,,,malaria,,,,, -15728394,2055,,affects,,Erythropoietin,,,,myocardial infarction,,,,, -15532613,2056,,affects,,Erythropoietin,,,,myocardial infarction,,,,, -12937865,2057,,affects,,Erythropoietin,,,,anemia,,,,, -12867407,2058,,affects,,Erythropoietin,,,,myocardial ischemia,,,,, -11701568,2059,,affects,,Erythropoietin,,,,Fatigue,,,,, -11563361,2060,,affects,,Erythropoietin,,,,neoplasm,,,,, -10970912,2061,,affects,,Erythropoietin,,,,brain injury,,,,, -10068762,2062,,affects,,Erythropoietin,,,,injury,,,,, -9989127,2063,,affects,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -9392180,2064,,affects,,Erythropoietin,,,,spinal cord injury,,,,, -8981317,2065,,affects,,Erythropoietin,,,,brain ischemia,,,,, -7400221,2066,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, -7278560,2067,,affects,,Erythropoietin,,,,anemia,,,,, -27259305,2068,,produces,,Erythropoietin,,,,acute kidney failure,,,,, -26811591,2069,,produces,,Erythropoietin,,,,HIV infectious disease,,,,, -26231858,2070,,produces,,Erythropoietin,,,,lymphoma,,,,, -14673419,2071,,produces,,Erythropoietin,,,,myocardial infarction,,,,, -11452049,2072,,produces,,Erythropoietin,,,,prostate cancer,,,,, -8829207,2073,,produces,,Erythropoietin,,,,neoplasm,,,,, -8032421,2074,,produces,,Erythropoietin,,,,chronic renal failure syndrome,,,,, -8032418,2075,,produces,,Erythropoietin,,,,chronic kidney disease,,,,, -7919214,2076,,produces,,Erythropoietin,,,,anemia,,,,, -7844664,2077,,produces,,Erythropoietin,,,,kidney failure,,,,, -17835656,2078,,disrupts,,Erythropoietin,,,,brain injury,,,,, -17602040,2079,,disrupts,,Erythropoietin,,,,Hemorrhage,,,,, -17384804,2080,,disrupts,,Erythropoietin,,,,Ischemic stroke,,,,, -15027834,2081,,disrupts,,Erythropoietin,,,,Fatigue,,,,, -13243471,2082,,disrupts,,Erythropoietin,,,,chronic kidney disease,,,,, -13033535,2083,,disrupts,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, -11253087,2084,,disrupts,,Erythropoietin,,,,injury,,,,, -8818732,2085,,disrupts,,Erythropoietin,,,,anemia,,,,, -22124183,2086,,prevents,,Erythropoietin,,,,Premature birth,,,,, -19522952,2087,,prevents,,Erythropoietin,,,,Asphyxia,,,,, -17246645,2088,,prevents,,Erythropoietin,,,,cerebral palsy,,,,, -16915551,2089,,prevents,,Erythropoietin,,,,coronary artery disorder,,,,, -16468664,2090,,prevents,,Erythropoietin,,,,optic neuritis,,,,, -16040441,2091,,prevents,,Erythropoietin,,,,spinal cord injury,,,,, -15444373,2092,,prevents,,Erythropoietin,,,,Parkinson disease,,,,, -14252439,2093,,prevents,,Erythropoietin,,,,kidney failure,,,,, -13347324,2094,,prevents,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, -13017739,2095,,prevents,,Erythropoietin,,,,chronic kidney disease,,,,, -11480928,2096,,prevents,,Erythropoietin,,,,Ischemic stroke,,,,, -11148609,2097,,prevents,,Erythropoietin,,,,myocardial ischemia,,,,, -11115141,2098,,prevents,,Erythropoietin,,,,stroke disorder,,,,, -10838253,2099,,prevents,,Erythropoietin,,,,necrotizing enterocolitis,,,,, -10766440,2100,,prevents,,Erythropoietin,,,,myocardial infarction,,,,, -10125087,2101,,prevents,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -8434315,2102,,prevents,,Erythropoietin,,,,injury,,,,, -8405867,2103,,prevents,,Erythropoietin,,,,brain ischemia,,,,, -8369017,2104,,prevents,,Erythropoietin,,,,brain injury,,,,, -7400218,2105,,prevents,,Erythropoietin,,,,Fatigue,,,,, -7236347,2106,,prevents,,Erythropoietin,,,,anemia,,,,, -18610239,2107,,exacerbates,,Erythropoietin,,,,injury,,,,, -14126866,2108,,exacerbates,,Erythropoietin,,,,anemia,,,,, -25818939,2109,,predisposes,,Erythropoietin,,,,neoplasm,,,,, -19869298,2110,,predisposes,,Erythropoietin,,,,coronary artery disorder,,,,, -19564296,2111,,predisposes,,Erythropoietin,,,,Asphyxia,,,,, -19270398,2112,,predisposes,,Erythropoietin,,,,brain injury,,,,, -18282528,2113,,predisposes,,Erythropoietin,,,,chronic kidney disease,,,,, -16056103,2114,,predisposes,,Erythropoietin,,,,Ischemic stroke,,,,, -14483144,2115,,predisposes,,Erythropoietin,,,,injury,,,,, -12166360,2116,,predisposes,,Erythropoietin,,,,kidney failure,,,,, -8361116,2117,,predisposes,,Erythropoietin,,,,anemia,,,,, -24327196,2118,,affects,,Daprodustat,,,,anemia,,,,, -24574810,2119,,prevents,,Daprodustat,,,,anemia,,,,, -19595886,2120,,related to,,mecobalamin,,,,vitamin B12 deficiency,,,,, -13417310,2121,,related to,,mecobalamin,,,,amyotrophic lateral sclerosis,,,,, -26391120,2122,,related to,,vitamin B12,,,,myocardial infarction,,,,, -21860699,2123,,related to,,vitamin B12,,,,type 2 diabetes mellitus,,,,, -20662929,2124,,related to,,vitamin B12,,,,non-small cell lung carcinoma,,,,, -19346996,2125,,related to,,vitamin B12,,,,myocardial ischemia,,,,, -12974621,2126,,related to,,vitamin B12,,,,osteoporosis,,,,, -10934739,2127,,related to,,vitamin B12,,,,chronic kidney disease,,,,, -10883089,2128,,related to,,vitamin B12,,,,depressive disorder,,,,, -10658870,2129,,related to,,vitamin B12,,,,psoriasis,,,,, -10535786,2130,,related to,,vitamin B12,,,,atherosclerosis,,,,, -10535188,2131,,related to,,vitamin B12,,,,lymphoma,,,,, -10508686,2132,,related to,,vitamin B12,,,,vitamin B12 deficiency,,,,, -10438501,2133,,related to,,vitamin B12,,,,iron deficiency anemia,,,,, -9977774,2134,,related to,,vitamin B12,,,,psychotic disorder,,,,, -9644935,2135,,related to,,vitamin B12,,,,anemia,,,,, -9118739,2136,,related to,,vitamin B12,,,,Low back pain,,,,, -8678107,2137,,related to,,vitamin B12,,,,Alzheimer disease,,,,, -27330642,2138,,causes,,vitamin B12,,,,depressive disorder,,,,, -26003936,2139,,causes,,vitamin B12,,,,diabetic neuropathy,,,,, -17687811,2140,,causes,,vitamin B12,,,,osteoporosis,,,,, -11993792,2141,,causes,,vitamin B12,,,,Reduced blood folate concentration,,,,, -10806959,2142,,causes,,vitamin B12,,,,psychotic disorder,,,,, -10716413,2143,,causes,,vitamin B12,,,,vitamin B12 deficiency,,,,, -9828196,2144,,causes,,vitamin B12,,,,anemia,,,,, -7900732,2145,,causes,,vitamin B12,,,,atherosclerosis,,,,, -25091008,2146,,affects,,vitamin B12,,,,HIV infectious disease,,,,, -20098295,2147,,affects,,vitamin B12,,,,depressive disorder,,,,, -19763864,2148,,affects,,vitamin B12,,,,Alzheimer disease,,,,, -18490813,2149,,affects,,vitamin B12,,,,depressive disorder,,,,, -17348852,2150,,affects,,vitamin B12,,,,vitamin B12 deficiency,,,,, -16930257,2151,,affects,,vitamin B12,,,,amyotrophic lateral sclerosis,,,,, -13607058,2152,,affects,,vitamin B12,,,,depressive disorder,,,,, -12773836,2153,,affects,,vitamin B12,,,,atherosclerosis,,,,, -11945900,2154,,affects,,vitamin B12,,,,Pregnancy,,,,, -11927611,2155,,affects,,vitamin B12,,,,diabetic neuropathy,,,,, -10798681,2156,,affects,,vitamin B12,,,,type 2 diabetes mellitus,,,,, -10424959,2157,,affects,,vitamin B12,,,,anemia,,,,, -8733280,2158,,affects,,vitamin B12,,,,Pregnancy,,,,, -8015838,2159,,affects,,vitamin B12,,,,chronic kidney disease,,,,, -23636866,2160,,produces,,vitamin B12,,,,vitamin B12 deficiency,,,,, -11124683,2161,,disrupts,,vitamin B12,,,,chronic kidney disease,,,,, -20603701,2162,,prevents,,vitamin B12,,,,Alzheimer disease,,,,, -14586818,2163,,prevents,,vitamin B12,,,,anemia,,,,, -10782972,2164,,prevents,,vitamin B12,,,,atherosclerosis,,,,, -9545669,2165,,prevents,,vitamin B12,,,,vitamin B12 deficiency,,,,, -27415421,2166,,predisposes,,vitamin B12,,,,myocardial infarction,,,,, -21063265,2167,,predisposes,,vitamin B12,,,,depressive disorder,,,,, -20875915,2168,,predisposes,,vitamin B12,,,,chronic kidney disease,,,,, -15081186,2169,,predisposes,,vitamin B12,,,,osteoporosis,,,,, -12678935,2170,,predisposes,,vitamin B12,,,,atherosclerosis,,,,, -12664527,2171,,predisposes,,vitamin B12,,,,Alzheimer disease,,,,, -8590188,2172,,predisposes,,vitamin B12,,,,anemia,,,,, -22149451,2173,,affects,,Ipragliflozin,,,,type 2 diabetes mellitus,,,,, -24120079,2174,,disrupts,,Ertugliflozin,,,,diabetes mellitus,,,,, -23006843,2175,,related to,,Empagliflozin,,,,diabetes mellitus,,,,, -22183651,2176,,related to,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, -24924157,2177,,causes,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, -23515975,2178,,causes,,Empagliflozin,,,,myocardial infarction,,,,, -23240834,2179,,causes,,Empagliflozin,,,,acute kidney failure,,,,, -25094844,2180,,affects,,Empagliflozin,,,,diabetes mellitus,,,,, -24520517,2181,,affects,,Empagliflozin,,,,Insulin resistance,,,,, -24184835,2182,,affects,,Empagliflozin,,,,diabetic kidney disease,,,,, -24091231,2183,,affects,,Empagliflozin,,,,kidney disorder,,,,, -22935616,2184,,affects,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, -22175650,2185,,affects,,Empagliflozin,,,,acute kidney failure,,,,, -22027265,2186,,affects,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, -21867589,2187,,affects,,Empagliflozin,,,,myocardial infarction,,,,, -21618629,2188,,affects,,Empagliflozin,,,,pulmonary arterial hypertension,,,,, -22842915,2189,,disrupts,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, -23528682,2190,,prevents,,Empagliflozin,,,,myocardial infarction,,,,, -23286446,2191,,prevents,,Empagliflozin,,,,acute kidney failure,,,,, -24551007,2192,,predisposes,,Empagliflozin,,,,acute kidney failure,,,,, -24497752,2193,,predisposes,,Empagliflozin,,,,hypoglycemia,,,,, -23163444,2194,,predisposes,,Empagliflozin,,,,diabetic kidney disease,,,,, -21786786,2195,,related to,,Dapagliflozin,,,,Alzheimer disease,,,,, -23582915,2196,,causes,,Dapagliflozin,,,,Weight loss,,,,, -25156234,2197,,affects,,Dapagliflozin,,,,non-alcoholic fatty liver disease,,,,, -23530734,2198,,affects,,Dapagliflozin,,,,Albuminuria,,,,, -23107287,2199,,affects,,Dapagliflozin,,,,type 1 diabetes mellitus,,,,, -23072376,2200,,affects,,Dapagliflozin,,,,ischemia reperfusion injury,,,,, -22916804,2201,,affects,,Dapagliflozin,,,,diabetic kidney disease,,,,, -22845588,2202,,affects,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, -22578057,2203,,affects,,Dapagliflozin,,,,Albuminuria,,,,, -22163310,2204,,affects,,Dapagliflozin,,,,Weight loss,,,,, -21622453,2205,,affects,,Dapagliflozin,,,,atrial fibrillation,,,,, -25362847,2206,,disrupts,,Dapagliflozin,,,,acute kidney failure,,,,, -23258105,2207,,disrupts,,Dapagliflozin,,,,kidney failure,,,,, -22845589,2208,,disrupts,,Dapagliflozin,,,,diabetes mellitus,,,,, -23973238,2209,,prevents,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, -23528684,2210,,prevents,,Dapagliflozin,,,,myocardial infarction,,,,, -23138841,2211,,prevents,,Dapagliflozin,,,,diabetic kidney disease,,,,, -22845590,2212,,prevents,,Dapagliflozin,,,,diabetes mellitus,,,,, -22832530,2213,,prevents,,Dapagliflozin,,,,kidney failure,,,,, -21513723,2214,,prevents,,Dapagliflozin,,,,obesity disorder,,,,, -25236689,2215,,predisposes,,Dapagliflozin,,,,kidney failure,,,,, -23072379,2216,,predisposes,,Dapagliflozin,,,,myocardial infarction,,,,, -20833370,2217,,related to,,Methyldopa,,,,type 1 diabetes mellitus,,,,, -15433400,2218,,related to,,Methyldopa,,,,preeclampsia,,,,, -7364754,2219,,related to,,Methyldopa,,,,hypertensive disorder,,,,, -25805913,2220,,causes,,Methyldopa,,,,hypertensive disorder,,,,, -23430063,2221,,causes,,Methyldopa,,,,preeclampsia,,,,, -26257846,2222,,affects,,Methyldopa,,,,hypertensive disorder,,,,, -10671192,2223,,affects,,Methyldopa,,,,hypertensive disorder,,,,, -26170425,2224,,prevents,,Methyldopa,,,,hypertensive disorder,,,,, -8219214,2225,,exacerbates,,Methyldopa,,,,hypertensive disorder,,,,, -20611289,2226,,predisposes,,Methyldopa,,,,preeclampsia,,,,, -19343164,2227,,related to,,Exemestane,,,,male breast carcinoma,,,,, -14849934,2228,,related to,,Exemestane,,,,ductal breast carcinoma in situ,,,,, -14694867,2229,,related to,,Exemestane,,,,non-small cell lung carcinoma,,,,, -11511167,2230,,related to,,Exemestane,,,,neoplasm,,,,, -18732584,2231,,affects,,Exemestane,,,,neoplasm,,,,, -14063167,2232,,affects,,Exemestane,,,,neoplasm,,,,, -16053578,2233,,prevents,,Exemestane,,,,breast neoplasm,,,,, -20235097,2234,,disrupts,,Rivizor,,,,neoplasm,,,,, -24226617,2235,,related to,,Letrozole,,,,polycystic ovary syndrome,,,,, -19925368,2236,,related to,,Letrozole,,,,infertility disorder,,,,, -13004646,2237,,related to,,Letrozole,,,,endometriosis,,,,, -11511165,2238,,related to,,Letrozole,,,,neoplasm,,,,, -22485512,2239,,causes,,Letrozole,,,,infertility disorder,,,,, -17708157,2240,,causes,,Letrozole,,,,neoplasm,,,,, -14659251,2241,,causes,,Letrozole,,,,endometriosis,,,,, -11078418,2242,,causes,,Letrozole,,,,polycystic ovary syndrome,,,,, -10282160,2243,,causes,,Letrozole,,,,hypogonadism,,,,, -25205942,2244,,affects,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, -18870552,2245,,affects,,Letrozole,,,,Pregnancy,,,,, -18835925,2246,,affects,,Letrozole,,,,inflammatory breast carcinoma,,,,, -10866444,2247,,affects,,Letrozole,,,,Pregnancy,,,,, -7871182,2248,,affects,,Letrozole,,,,neoplasm,,,,, -21352213,2249,,disrupts,,Letrozole,,,,Pregnancy,,,,, -25448977,2250,,prevents,,Letrozole,,,,prostate cancer,,,,, -19305611,2251,,prevents,,Letrozole,,,,Spontaneous abortion,,,,, -17892609,2252,,prevents,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, -13373696,2253,,prevents,,Letrozole,,,,neoplasm,,,,, -20363763,2254,,predisposes,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, -19305612,2255,,predisposes,,Letrozole,,,,Spontaneous abortion,,,,, -26765214,2256,,affects,,Formestane,,,,neoplasm,,,,, -25526748,2257,,disrupts,,Formestane,,,,neoplasm,,,,, -13022860,2258,,prevents,,Formestane,,,,neoplasm,,,,, -26325498,2259,,affects,,Aminoglutethimide,,,,neoplasm,,,,, -12185634,2260,,affects,,Aminoglutethimide,,,,neoplasm,,,,, -22275813,2261,,related to,,Relugolix,,,,prostate cancer,,,,, -23469407,2262,,prevents,,Relugolix,,,,Pain,,,,, -25422975,2263,,related to,,Abiraterone,,,,castration-resistant prostate carcinoma,,,,, -20717678,2264,,related to,,Abiraterone,,,,prostate cancer,,,,, -16721978,2265,,affects,,Abiraterone,,,,prostate cancer,,,,, -15794241,2266,,prevents,,Abiraterone,,,,neoplasm,,,,, -19010753,2267,,predisposes,,Abiraterone,,,,prostate cancer,,,,, -11344546,2268,,related to,,Finasteride,,,,acne,,,,, -11344545,2269,,related to,,Finasteride,,,,alopecia,,,,, -9840638,2270,,related to,,Finasteride,,,,prostate cancer,,,,, -7359591,2271,,related to,,Finasteride,,,,benign prostatic hyperplasia,,,,, -21759063,2272,,causes,,Finasteride,,,,benign prostatic hyperplasia,,,,, -11694493,2273,,causes,,Finasteride,,,,prostate cancer,,,,, -11326933,2274,,affects,,Finasteride,,,,prostate cancer,,,,, -9873046,2275,,affects,,Finasteride,,,,benign prostatic hyperplasia,,,,, -9845785,2276,,affects,,Finasteride,,,,alopecia,,,,, -7857572,2277,,affects,,Finasteride,,,,prostate cancer,,,,, -21155186,2278,,disrupts,,Finasteride,,,,benign prostatic hyperplasia,,,,, -10949204,2279,,disrupts,,Finasteride,,,,prostate cancer,,,,, -7931250,2280,,disrupts,,Finasteride,,,,alopecia,,,,, -11279550,2281,,prevents,,Finasteride,,,,benign prostatic hyperplasia,,,,, -8938663,2282,,prevents,,Finasteride,,,,alopecia,,,,, -7857569,2283,,prevents,,Finasteride,,,,prostate cancer,,,,, -9840634,2284,,predisposes,,Finasteride,,,,prostate cancer,,,,, -8913536,2285,,predisposes,,Finasteride,,,,benign prostatic hyperplasia,,,,, -15677403,2286,,related to,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -14665250,2287,,related to,,Dutasteride,,,,prostate cancer,,,,, -22506276,2288,,causes,,Dutasteride,,,,prostatitis,,,,, -14995448,2289,,affects,,Dutasteride,,,,prostate cancer,,,,, -11407079,2290,,affects,,Dutasteride,,,,prostatitis,,,,, -10333399,2291,,affects,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -15838005,2292,,disrupts,,Dutasteride,,,,prostate cancer,,,,, -16876475,2293,,prevents,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -13018366,2294,,prevents,,Dutasteride,,,,alopecia,,,,, -12506526,2295,,prevents,,Dutasteride,,,,prostate cancer,,,,, -13749427,2296,,predisposes,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -13628345,2297,,predisposes,,Dutasteride,,,,prostate cancer,,,,, -23122900,2298,,related to,,Celecoxib,,,,Pain,,,,, -20821764,2299,,related to,,Celecoxib,,,,prostate cancer,,,,, -14485082,2300,,related to,,Celecoxib,,,,castration-resistant prostate carcinoma,,,,, -14288130,2301,,related to,,Celecoxib,,,,neoplasm,,,,, -15210658,2302,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, -15210658,2303,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11056859,2304,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11056859,2305,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -19664582,2306,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -19664582,2307,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -8460221,2308,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -9140190,2309,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -22101111,2310,,causes,,Celecoxib,,,,Alzheimer disease,,,,, -21110777,2311,,causes,,Celecoxib,,,,schizophrenia,,,,, -20555672,2312,,causes,,Celecoxib,,,,hepatocellular carcinoma,,,,, -14478589,2313,,causes,,Celecoxib,,,,Inflammation,,,,, -14396158,2314,,causes,,Celecoxib,,,,neoplasm,,,,, -13894212,2315,,causes,,Celecoxib,,,,peptic ulcer disease,,,,, -13829410,2316,,causes,,Celecoxib,,,,Pain,,,,, -12882318,2317,,causes,,Celecoxib,,,,colorectal neoplasm,,,,, -12147702,2318,,causes,,Celecoxib,,,,osteoarthritis,,,,, -12029200,2319,,causes,,Celecoxib,,,,Hemorrhage,,,,, -10018014,2320,,causes,,Celecoxib,,,,hypertensive disorder,,,,, -25555760,2321,,affects,,Celecoxib,,,,postpartum depression,,,,, -21116356,2322,,affects,,Celecoxib,,,,major depressive disorder,,,,, -19634803,2323,,affects,,Celecoxib,,,,Hemorrhage,,,,, -18087191,2324,,affects,,Celecoxib,,,,breast neoplasm,,,,, -17669654,2325,,affects,,Celecoxib,,,,glioma,,,,, -17634409,2326,,affects,,Celecoxib,,,,depressive disorder,,,,, -16787676,2327,,affects,,Celecoxib,,,,hypertensive disorder,,,,, -15889622,2328,,affects,,Celecoxib,,,,osteoarthritis,,,,, -13667242,2329,,affects,,Celecoxib,,,,obesity disorder,,,,, -13414910,2330,,affects,,Celecoxib,,,,Hemorrhage,,,,, -13122831,2331,,affects,,Celecoxib,,,,hypertensive disorder,,,,, -12419082,2332,,affects,,Celecoxib,,,,neoplasm,,,,, -11947530,2333,,affects,,Celecoxib,,,,hepatocellular carcinoma,,,,, -11444192,2334,,affects,,Celecoxib,,,,neoplasm,,,,, -11303331,2335,,affects,,Celecoxib,,,,non-small cell lung carcinoma,,,,, -10337670,2336,,affects,,Celecoxib,,,,colorectal neoplasm,,,,, -10157341,2337,,affects,,Celecoxib,,,,injury,,,,, -9967873,2338,,affects,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -9574485,2339,,affects,,Celecoxib,,,,schizophrenia,,,,, -9038473,2340,,affects,,Celecoxib,,,,peptic ulcer disease,,,,, -7841958,2341,,affects,,Celecoxib,,,,rheumatoid arthritis,,,,, -7726669,2342,,affects,,Celecoxib,,,,Pain,,,,, -7726668,2343,,affects,,Celecoxib,,,,Inflammation,,,,, -7264055,2344,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11464194,2345,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11846592,2346,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11846592,2347,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, -14865798,2348,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, -14865798,2349,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, -22029254,2350,,disrupts,,Celecoxib,,,,major depressive disorder,,,,, -16862201,2351,,disrupts,,Celecoxib,,,,hepatocellular carcinoma,,,,, -15337601,2352,,disrupts,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -15029907,2353,,disrupts,,Celecoxib,,,,Pain,,,,, -14234726,2354,,disrupts,,Celecoxib,,,,adenoma,,,,, -12025752,2355,,disrupts,,Celecoxib,,,,colonic neoplasm,,,,, -9589598,2356,,disrupts,,Celecoxib,,,,neoplasm,,,,, -9384934,2357,,disrupts,,Celecoxib,,,,breast neoplasm,,,,, -8528907,2358,,disrupts,,Celecoxib,,,,Inflammation,,,,, -19393781,2359,,prevents,,Celecoxib,,,,stroke disorder,,,,, -18309561,2360,,prevents,,Celecoxib,,,,hepatocellular carcinoma,,,,, -17468664,2361,,prevents,,Celecoxib,,,,non-small cell lung carcinoma,,,,, -16386169,2362,,prevents,,Celecoxib,,,,actinic keratosis,,,,, -16323754,2363,,prevents,,Celecoxib,,,,hypertensive disorder,,,,, -15947575,2364,,prevents,,Celecoxib,,,,osteoarthritis,,,,, -15337603,2365,,prevents,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -14688780,2366,,prevents,,Celecoxib,,,,Low back pain,,,,, -13346756,2367,,prevents,,Celecoxib,,,,prostate cancer,,,,, -12969778,2368,,prevents,,Celecoxib,,,,neuroblastoma,,,,, -12687466,2369,,prevents,,Celecoxib,,,,adenoma,,,,, -11060421,2370,,prevents,,Celecoxib,,,,classic familial adenomatous polyposis,,,,, -10931690,2371,,prevents,,Celecoxib,,,,breast neoplasm,,,,, -10337661,2372,,prevents,,Celecoxib,,,,colorectal neoplasm,,,,, -9969498,2373,,prevents,,Celecoxib,,,,Acute Pain,,,,, -9525867,2374,,prevents,,Celecoxib,,,,injury,,,,, -9508533,2375,,prevents,,Celecoxib,,,,Pain,,,,, -8844228,2376,,prevents,,Celecoxib,,,,Inflammation,,,,, -7720173,2377,,prevents,,Celecoxib,,,,neoplasm,,,,, -14426267,2378,,predisposes,,Celecoxib,,,,Inflammation,,,,, -12799788,2379,,predisposes,,Celecoxib,,,,hypertensive disorder,,,,, -11130431,2380,,predisposes,,Celecoxib,,,,injury,,,,, -12352394,2381,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -12352394,2382,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -14685035,2383,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -14685035,2384,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -8460222,2385,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -9140191,2386,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -10265772,2387,,causes,,Rofecoxib,,,,Pain,,,,, -13140649,2388,,affects,,Rofecoxib,,,,Pain,,,,, -13143485,2389,,affects,,Rofecoxib,,,,osteoarthritis,,,,, -12129893,2390,,affects,,Rofecoxib,,,,adenoma,,,,, -11539323,2391,,affects,,Rofecoxib,,,,Pain,,,,, -10337671,2392,,affects,,Rofecoxib,,,,colorectal neoplasm,,,,, -8436303,2393,,affects,,Rofecoxib,,,,osteoarthritis,,,,, -7546790,2394,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -11143316,2395,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -11899486,2396,,disrupts,,Rofecoxib,,,,Pain,,,,, -12422414,2397,,prevents,,Rofecoxib,,,,adenoma,,,,, -10337662,2398,,prevents,,Rofecoxib,,,,colorectal neoplasm,,,,, -9488144,2399,,prevents,,Rofecoxib,,,,Pain,,,,, -12808149,2400,,predisposes,,Rofecoxib,,,,adenoma,,,,, -21440548,2401,,affects,,Etoricoxib,,,,osteoarthritis,,,,, -17783506,2402,,affects,,Etoricoxib,,,,injury,,,,, -15015650,2403,,affects,,Etoricoxib,,,,Pain,,,,, -13276651,2404,,affects,,Etoricoxib,,,,rheumatic disorder,,,,, -8656381,2405,,affects,,Etoricoxib,,,,Cyclooxygenase 2,,,,, -21271381,2406,,prevents,,Etoricoxib,,,,osteoarthritis,,,,, -17783508,2407,,prevents,,Etoricoxib,,,,injury,,,,, -13679347,2408,,prevents,,Etoricoxib,,,,Pain,,,,, -11619190,2409,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -11619190,2410,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -17164065,2411,,physically interacts with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -13276652,2412,,affects,,Lumiracoxib,,,,rheumatic disorder,,,,, -10245332,2413,,affects,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -13077914,2414,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, -11476053,2415,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, -9552647,2416,,affects,,Valdecoxib,,,,Cyclooxygenase 2,,,,, -11215677,2417,,disrupts,,Valdecoxib,,,,Pain,,,,, -15156435,2418,,prevents,,Valdecoxib,,,,pancreatitis,,,,, -10035578,2419,,prevents,,Valdecoxib,,,,Pain,,,,, -17909160,2420,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, -17909160,2421,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, -16597136,2422,,affects,,Parecoxib,,,,Shoulder pain,,,,, -13492238,2423,,affects,,Parecoxib,,,,Pain,,,,, -12600950,2424,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, -18579418,2425,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, -18207264,2426,,disrupts,,Parecoxib,,,,Pain,,,,, -16597135,2427,,prevents,,Parecoxib,,,,Shoulder pain,,,,, -14081775,2428,,prevents,,Parecoxib,,,,Pain,,,,, -22281663,2429,,related to,,Drospirenone,,,,polycystic ovary syndrome,,,,, -21546756,2430,,related to,,Drospirenone,,,,acne,,,,, -20964606,2431,,predisposes,,Drospirenone,,,,polycystic ovary syndrome,,,,, -8455182,2432,,related to,,Ropinirole,,,,Parkinson disease,,,,, -17774585,2433,,causes,,Ropinirole,,,,Parkinson disease,,,,, -14587825,2434,,affects,,Ropinirole,,,,Parkinson disease,,,,, -11791368,2435,,affects,,Ropinirole,,,,restless legs syndrome,,,,, -9334943,2436,,disrupts,,Ropinirole,,,,Parkinson disease,,,,, -10286489,2437,,prevents,,Ropinirole,,,,Parkinson disease,,,,, -27727471,2438,,related to,,Pergolide,,,,Parkinson disease,,,,, -11914502,2439,,causes,,Pergolide,,,,Parkinson disease,,,,, -10881399,2440,,affects,,Pergolide,,,,Parkinson disease,,,,, -16163315,2441,,related to,,Bromocriptine,,,,Parkinson disease,,,,, -15233295,2442,,related to,,Bromocriptine,,,,type 1 diabetes mellitus,,,,, -17352665,2443,,causes,,Bromocriptine,,,,obesity disorder,,,,, -12630193,2444,,causes,,Bromocriptine,,,,Parkinson disease,,,,, -22488533,2445,,affects,,Bromocriptine,,,,adenomyosis,,,,, -20888778,2446,,affects,,Bromocriptine,,,,Parkinson disease,,,,, -27647530,2447,,prevents,,Bromocriptine,,,,obesity disorder,,,,, -15529387,2448,,prevents,,Bromocriptine,,,,ovarian hyperstimulation syndrome,,,,, -18216941,2449,,causes,,Piribedil,,,,Parkinson disease,,,,, -8408670,2450,,affects,,Piribedil,,,,Parkinson disease,,,,, -8818724,2451,,related to,,Apomorphine,,,,Parkinson disease,,,,, -23018637,2452,,causes,,Apomorphine,,,,erectile dysfunction,,,,, -11364291,2453,,causes,,Apomorphine,,,,Parkinson disease,,,,, -8320181,2454,,affects,,Apomorphine,,,,Parkinson disease,,,,, -16869339,2455,,related to,,Cabergoline,,,,Parkinson disease,,,,, -19536611,2456,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, -15320456,2457,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, -20751353,2458,,causes,,Cabergoline,,,,endometriosis,,,,, -26585560,2459,,affects,,Cabergoline,,,,pituitary tumor,,,,, -19237315,2460,,affects,,Cabergoline,,,,endometriosis,,,,, -17463083,2461,,affects,,Cabergoline,,,,Dopamine D2 Receptor,,,,, -12695381,2462,,affects,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, -13380476,2463,,prevents,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, -9194241,2464,,predisposes,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, -15982499,2465,,related to,,Pramipexole,,,,restless legs syndrome,,,,, -9735890,2466,,related to,,Pramipexole,,,,Parkinson disease,,,,, -21401262,2467,,causes,,Pramipexole,,,,restless legs syndrome,,,,, -15033700,2468,,causes,,Pramipexole,,,,obsessive-compulsive disorder,,,,, -13328857,2469,,causes,,Pramipexole,,,,Parkinson disease,,,,, -18143671,2470,,affects,,Pramipexole,,,,depressive disorder,,,,, -12990655,2471,,affects,,Pramipexole,,,,restless legs syndrome,,,,, -12579916,2472,,affects,,Pramipexole,,,,depressive disorder,,,,, -10881401,2473,,affects,,Pramipexole,,,,Parkinson disease,,,,, -11457313,2474,,prevents,,Pramipexole,,,,Parkinson disease,,,,, -24610805,2475,,affects,,Rotigotine,,,,Parkinson disease,,,,, -10840977,2476,,subclass of,,Norethindrone,,,,Norethindrone acetate,,,,, -8232443,2477,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, -11686400,2478,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, -9474851,2479,,coexists with,,Norethindrone,,,,Norethindrone acetate,,,,, -9781055,2480,,physically interacts with,,Norethindrone,,,,Norethindrone acetate,,,,, -21462883,2481,,causes,,Norethindrone,,,,neoplasm,,,,, -27429354,2482,,affects,,Pramocaine,,,,Pruritus,,,,, -19275366,2483,,disrupts,,Miconazole,,,,fungal infectious disease,,,,, -26511975,2484,,prevents,,Miconazole,,,,fungal infectious disease,,,,, -26530559,2485,,affects,,Benzocaine,,,,Pain,,,,, -8870493,2486,,disrupts,,Benzocaine,,,,Pain,,,,, -8870496,2487,,prevents,,Benzocaine,,,,Pain,,,,, -25561815,2488,,related to,,Folic Acid,,,,systemic lupus erythematosus,,,,, -23703706,2489,,related to,,Folic Acid,,,,neoplasm of esophagus,,,,, -23248765,2490,,related to,,Folic Acid,,,,chronic renal failure syndrome,,,,, -20038856,2491,,related to,,Folic Acid,,,,psychotic disorder,,,,, -19346997,2492,,related to,,Folic Acid,,,,myocardial ischemia,,,,, -19301020,2493,,related to,,Folic Acid,,,,type 2 diabetes mellitus,,,,, -19114314,2494,,related to,,Folic Acid,,,,tuberculosis,,,,, -18323097,2495,,related to,,Folic Acid,,,,HIV infectious disease,,,,, -17591518,2496,,related to,,Folic Acid,,,,infertility disorder,,,,, -15826430,2497,,related to,,Folic Acid,,,,male infertility,,,,, -14280104,2498,,related to,,Folic Acid,,,,myocardial infarction,,,,, -12974622,2499,,related to,,Folic Acid,,,,osteoporosis,,,,, -12112288,2500,,related to,,Folic Acid,,,,autism spectrum disorder,,,,, -11305980,2501,,related to,,Folic Acid,,,,cleft palate,,,,, -10745702,2502,,related to,,Folic Acid,,,,malaria,,,,, -10717915,2503,,related to,,Folic Acid,,,,habitual spontaneous abortion,,,,, -10644755,2504,,related to,,Folic Acid,,,,atherosclerosis,,,,, -10226420,2505,,related to,,Folic Acid,,,,cervical polyp,,,,, -10177078,2506,,related to,,Folic Acid,,,,colorectal neoplasm,,,,, -10046990,2507,,related to,,Folic Acid,,,,depressive disorder,,,,, -9815747,2508,,related to,,Folic Acid,,,,hypertensive disorder,,,,, -9628243,2509,,related to,,Folic Acid,,,,mesothelioma,,,,, -9628242,2510,,related to,,Folic Acid,,,,non-small cell lung carcinoma,,,,, -9060030,2511,,related to,,Folic Acid,,,,neoplasm,,,,, -8875457,2512,,related to,,Folic Acid,,,,lymphoma,,,,, -8584638,2513,,related to,,Folic Acid,,,,sickle cell anemia,,,,, -8274471,2514,,related to,,Folic Acid,,,,chronic kidney disease,,,,, -8259960,2515,,related to,,Folic Acid,,,,type 1 diabetes mellitus,,,,, -8078141,2516,,related to,,Folic Acid,,,,Alzheimer disease,,,,, -7868306,2517,,related to,,Folic Acid,,,,coronary artery disorder,,,,, -7765942,2518,,related to,,Folic Acid,,,,anemia,,,,, -7303518,2519,,related to,,Folic Acid,,,,epilepsy,,,,, -7234301,2520,,related to,,Folic Acid,,,,Reduced blood folate concentration,,,,, -7229825,2521,,related to,,Folic Acid,,,,iron deficiency anemia,,,,, -7175279,2522,,related to,,Folic Acid,,,,rheumatoid arthritis,,,,, -25522909,2523,,causes,,Folic Acid,,,,diabetic kidney disease,,,,, -18689556,2524,,causes,,Folic Acid,,,,Alzheimer disease,,,,, -17559847,2525,,causes,,Folic Acid,,,,iron deficiency anemia,,,,, -17044072,2526,,causes,,Folic Acid,,,,depressive disorder,,,,, -15826434,2527,,causes,,Folic Acid,,,,male infertility,,,,, -15057448,2528,,causes,,Folic Acid,,,,chronic kidney disease,,,,, -14954987,2529,,causes,,Folic Acid,,,,autism spectrum disorder,,,,, -13825749,2530,,causes,,Folic Acid,,,,cleft lip,,,,, -13656973,2531,,causes,,Folic Acid,,,,neoplasm,,,,, -12212539,2532,,causes,,Folic Acid,,,,lymphoma,,,,, -11472417,2533,,causes,,Folic Acid,,,,gingival overgrowth,,,,, -11073752,2534,,causes,,Folic Acid,,,,myocardial ischemia,,,,, -10016854,2535,,causes,,Folic Acid,,,,hypertensive disorder,,,,, -8671948,2536,,causes,,Folic Acid,,,,cleft palate,,,,, -8640403,2537,,causes,,Folic Acid,,,,epilepsy,,,,, -7900734,2538,,causes,,Folic Acid,,,,coronary artery disorder,,,,, -7900729,2539,,causes,,Folic Acid,,,,atherosclerosis,,,,, -7637475,2540,,causes,,Folic Acid,,,,Reduced blood folate concentration,,,,, -7460069,2541,,causes,,Folic Acid,,,,anemia,,,,, -7392389,2542,,causes,,Folic Acid,,,,neural tube defect,,,,, -27400709,2543,,affects,,Folic Acid,,,,coronary artery disorder,,,,, -27350602,2544,,affects,,Folic Acid,,,,cleft palate,,,,, -26684582,2545,,affects,,Folic Acid,,,,colorectal neoplasm,,,,, -26504524,2546,,affects,,Folic Acid,,,,neoplasm,,,,, -26433324,2547,,affects,,Folic Acid,,,,psychotic disorder,,,,, -25046427,2548,,affects,,Folic Acid,,,,malaria,,,,, -24121807,2549,,affects,,Folic Acid,,,,osteoporosis,,,,, -23769753,2550,,affects,,Folic Acid,,,,anemia,,,,, -22602503,2551,,affects,,Folic Acid,,,,gingival overgrowth,,,,, -21177262,2552,,affects,,Folic Acid,,,,autism spectrum disorder,,,,, -20060781,2553,,affects,,Folic Acid,,,,Hemorrhage,,,,, -19336710,2554,,affects,,Folic Acid,,,,polycystic ovary syndrome,,,,, -19172236,2555,,affects,,Folic Acid,,,,chronic kidney disease,,,,, -19066599,2556,,affects,,Folic Acid,,,,Alzheimer disease,,,,, -15798837,2557,,affects,,Folic Acid,,,,hypertensive disorder,,,,, -15143772,2558,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, -14869410,2559,,affects,,Folic Acid,,,,epilepsy,,,,, -14664528,2560,,affects,,Folic Acid,,,,depressive disorder,,,,, -14002988,2561,,affects,,Folic Acid,,,,depressive disorder,,,,, -13092563,2562,,affects,,Folic Acid,,,,depressive disorder,,,,, -12773835,2563,,affects,,Folic Acid,,,,atherosclerosis,,,,, -11897009,2564,,affects,,Folic Acid,,,,Alzheimer disease,,,,, -10798682,2565,,affects,,Folic Acid,,,,type 2 diabetes mellitus,,,,, -10733114,2566,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, -10375553,2567,,affects,,Folic Acid,,,,neoplasm,,,,, -10355008,2568,,affects,,Folic Acid,,,,anemia,,,,, -8962241,2569,,affects,,Folic Acid,,,,cleft palate,,,,, -8101952,2570,,affects,,Folic Acid,,,,neural tube defect,,,,, -7127212,2571,,affects,,Folic Acid,,,,neural tube defect,,,,, -19290979,2572,,produces,,Folic Acid,,,,neoplasm,,,,, -26301481,2573,,disrupts,,Folic Acid,,,,epilepsy,,,,, -22602502,2574,,disrupts,,Folic Acid,,,,gingival overgrowth,,,,, -21452213,2575,,disrupts,,Folic Acid,,,,cleft palate,,,,, -20711939,2576,,disrupts,,Folic Acid,,,,autism spectrum disorder,,,,, -20091947,2577,,disrupts,,Folic Acid,,,,atherosclerosis,,,,, -18758283,2578,,disrupts,,Folic Acid,,,,malaria,,,,, -18711179,2579,,disrupts,,Folic Acid,,,,hypertensive disorder,,,,, -16597425,2580,,disrupts,,Folic Acid,,,,neoplasm,,,,, -13887579,2581,,disrupts,,Folic Acid,,,,anemia,,,,, -13415357,2582,,disrupts,,Folic Acid,,,,cleft lip,,,,, -12569851,2583,,disrupts,,Folic Acid,,,,HIV infectious disease,,,,, -11807458,2584,,disrupts,,Folic Acid,,,,colorectal neoplasm,,,,, -10170875,2585,,disrupts,,Folic Acid,,,,depressive disorder,,,,, -8333532,2586,,disrupts,,Folic Acid,,,,neural tube defect,,,,, -8088152,2587,,disrupts,,Folic Acid,,,,Reduced blood folate concentration,,,,, -7255352,2588,,disrupts,,Folic Acid,,,,coronary artery disorder,,,,, -24827653,2589,,prevents,,Folic Acid,,,,Hemorrhage,,,,, -19249670,2590,,prevents,,Folic Acid,,,,epilepsy,,,,, -18676969,2591,,prevents,,Folic Acid,,,,neoplasm,,,,, -17577921,2592,,prevents,,Folic Acid,,,,diabetic kidney disease,,,,, -16233198,2593,,prevents,,Folic Acid,,,,iron deficiency anemia,,,,, -15458838,2594,,prevents,,Folic Acid,,,,myocardial ischemia,,,,, -15385859,2595,,prevents,,Folic Acid,,,,depressive disorder,,,,, -13602735,2596,,prevents,,Folic Acid,,,,gingival overgrowth,,,,, -12999215,2597,,prevents,,Folic Acid,,,,hypertensive disorder,,,,, -12947495,2598,,prevents,,Folic Acid,,,,cleft lip,,,,, -12911127,2599,,prevents,,Folic Acid,,,,Alzheimer disease,,,,, -11842763,2600,,prevents,,Folic Acid,,,,cervical polyp,,,,, -10283354,2601,,prevents,,Folic Acid,,,,heart disorder,,,,, -10242010,2602,,prevents,,Folic Acid,,,,cleft palate,,,,, -9547944,2603,,prevents,,Folic Acid,,,,atherosclerosis,,,,, -9000016,2604,,prevents,,Folic Acid,,,,anemia,,,,, -8746975,2605,,prevents,,Folic Acid,,,,Reduced blood folate concentration,,,,, -8675157,2606,,prevents,,Folic Acid,,,,coronary artery disorder,,,,, -8467407,2607,,prevents,,Folic Acid,,,,myocardial infarction,,,,, -7303516,2608,,prevents,,Folic Acid,,,,neural tube defect,,,,, -23795062,2609,,predisposes,,Folic Acid,,,,depressive disorder,,,,, -20875914,2610,,predisposes,,Folic Acid,,,,chronic kidney disease,,,,, -20436878,2611,,predisposes,,Folic Acid,,,,psychotic disorder,,,,, -19071958,2612,,predisposes,,Folic Acid,,,,type 1 diabetes mellitus,,,,, -18723777,2613,,predisposes,,Folic Acid,,,,systemic lupus erythematosus,,,,, -16571781,2614,,predisposes,,Folic Acid,,,,habitual spontaneous abortion,,,,, -16186991,2615,,predisposes,,Folic Acid,,,,Reduced blood folate concentration,,,,, -15780148,2616,,predisposes,,Folic Acid,,,,epilepsy,,,,, -15351663,2617,,predisposes,,Folic Acid,,,,breast neoplasm,,,,, -14681570,2618,,predisposes,,Folic Acid,,,,malaria,,,,, -13204073,2619,,predisposes,,Folic Acid,,,,autism spectrum disorder,,,,, -12966788,2620,,predisposes,,Folic Acid,,,,cleft palate,,,,, -12851634,2621,,predisposes,,Folic Acid,,,,osteoporosis,,,,, -12628867,2622,,predisposes,,Folic Acid,,,,neoplasm,,,,, -11373442,2623,,predisposes,,Folic Acid,,,,colorectal neoplasm,,,,, -11241979,2624,,predisposes,,Folic Acid,,,,hypertensive disorder,,,,, -9419598,2625,,predisposes,,Folic Acid,,,,Alzheimer disease,,,,, -9024956,2626,,predisposes,,Folic Acid,,,,non-small cell lung carcinoma,,,,, -8876702,2627,,predisposes,,Folic Acid,,,,atherosclerosis,,,,, -8590186,2628,,predisposes,,Folic Acid,,,,anemia,,,,, -8210149,2629,,predisposes,,Folic Acid,,,,myocardial ischemia,,,,, -8202566,2630,,predisposes,,Folic Acid,,,,coronary artery disorder,,,,, -7807562,2631,,predisposes,,Folic Acid,,,,myocardial infarction,,,,, -7720012,2632,,subclass of,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -26246718,2633,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -25613560,2634,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -20340997,2635,,physically interacts with,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -26417219,2636,,physically interacts with,,Phenylbutazone,,,,"1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",,,,, -17467114,2637,,affects,,Phenylbutazone,,,,rheumatic disorder,,,,, -8146434,2638,,affects,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -7720012,2639,,subclass of,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -25613560,2640,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -26246718,2641,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -20340997,2642,,physically interacts with,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -8146434,2643,,affects,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -19336632,2644,,prevents,,Etofenamate,,,,Arthralgia,,,,, -11418550,2645,,subclass of,,Piroxicam,,,,5'-Hydroxypiroxicam,,,,, -27695181,2646,,affects,,Piroxicam,,,,osteoarthritis,,,,, -24435495,2647,,affects,,Piroxicam,,,,Pain,,,,, -18791248,2648,,disrupts,,Piroxicam,,,,Pain,,,,, -13746683,2649,,prevents,,Piroxicam,,,,Myalgia,,,,, -13092622,2650,,prevents,,Piroxicam,,,,Pain,,,,, -9050885,2651,,related to,,Bufexamac,,,,rheumatic disorder,,,,, -27600921,2652,,related to,,Mometasone furoate,,,,psoriasis,,,,, -26936147,2653,,related to,,Mometasone furoate,,,,skin disorder,,,,, -20328277,2654,,related to,,Mometasone furoate,,,,obstructive sleep apnea syndrome,,,,, -20031657,2655,,related to,,Mometasone furoate,,,,diffuse alopecia areata,,,,, -18451558,2656,,related to,,Mometasone furoate,,,,spinal cord injury,,,,, -15193244,2657,,related to,,Mometasone furoate,,,,severe acute respiratory syndrome,,,,, -12129006,2658,,related to,,Mometasone furoate,,,,asthma,,,,, -12122099,2659,,related to,,Mometasone furoate,,,,allergic rhinitis,,,,, -11696210,2660,,related to,,Mometasone furoate,,,,chronic obstructive pulmonary disease,,,,, -10078337,2661,,related to,,Mometasone furoate,,,,perennial allergic rhinitis,,,,, -8366912,2662,,related to,,Mometasone furoate,,,,seasonal allergic rhinitis,,,,, -15620377,2663,,affects,,Mometasone furoate,,,,asthma,,,,, -14474022,2664,,affects,,Mometasone furoate,,,,Nasal congestion,,,,, -8375063,2665,,affects,,Mometasone furoate,,,,allergic rhinitis,,,,, -17026384,2666,,prevents,,Mometasone furoate,,,,Nasal congestion,,,,, -15945486,2667,,prevents,,Mometasone furoate,,,,nasal cavity polyp,,,,, -10581126,2668,,related to,,Methimazole,,,,hyperthyroidism,,,,, -8213703,2669,,causes,,Methimazole,,,,hyperthyroidism,,,,, -10543639,2670,,affects,,Methimazole,,,,hyperthyroidism,,,,, -25010771,2671,,prevents,,Methimazole,,,,hyperthyroidism,,,,, -24946616,2672,,physically interacts with,,Safinamide,,,,Monoamine Oxidase B,,,,, -19231919,2673,,affects,,Safinamide,,,,Parkinson disease,,,,, -13464423,2674,,affects,,Safinamide,,,,Monoamine Oxidase B,,,,, -25942595,2675,,related to,,Furosemide,,,,nephrotic syndrome,,,,, -25824332,2676,,related to,,Furosemide,,,,Fibrosis,,,,, -25791999,2677,,related to,,Furosemide,,,,cirrhosis of liver,,,,, -25414865,2678,,related to,,Furosemide,,,,syndromic disease,,,,, -24461287,2679,,related to,,Furosemide,,,,essential hypertension,,,,, -22834232,2680,,related to,,Furosemide,,,,type 2 diabetes mellitus,,,,, -19148228,2681,,related to,,Furosemide,,,,hypertensive disorder,,,,, -13031496,2682,,related to,,Furosemide,,,,acute kidney failure,,,,, -8084093,2683,,related to,,Furosemide,,,,kidney failure,,,,, -27482853,2684,,causes,,Furosemide,,,,Edema,,,,, -27015887,2685,,causes,,Furosemide,,,,diabetes mellitus,,,,, -25990601,2686,,causes,,Furosemide,,,,hypertensive disorder,,,,, -25918508,2687,,causes,,Furosemide,,,,kidney disorder,,,,, -20167150,2688,,causes,,Furosemide,,,,syndromic disease,,,,, -19659078,2689,,causes,,Furosemide,,,,kidney failure,,,,, -11605290,2690,,causes,,Furosemide,,,,nephrotic syndrome,,,,, -9601857,2691,,causes,,Furosemide,,,,acute kidney failure,,,,, -8252635,2692,,causes,,Furosemide,,,,Dyspnea,,,,, -26185017,2693,,affects,,Furosemide,,,,myocardial infarction,,,,, -25909260,2694,,affects,,Furosemide,,,,nephrotic syndrome,,,,, -22504977,2695,,affects,,Furosemide,,,,cirrhosis of liver,,,,, -17729926,2696,,affects,,Furosemide,,,,Edema,,,,, -16155102,2697,,affects,,Furosemide,,,,kidney disorder,,,,, -15732141,2698,,affects,,Furosemide,,,,hypertensive disorder,,,,, -14935630,2699,,affects,,Furosemide,,,,kidney failure,,,,, -14887041,2700,,affects,,Furosemide,,,,acute kidney failure,,,,, -14148250,2701,,affects,,Furosemide,,,,kidney failure,,,,, -13740455,2702,,affects,,Furosemide,,,,Dyspnea,,,,, -12836864,2703,,affects,,Furosemide,,,,Edema,,,,, -10718312,2704,,affects,,Furosemide,,,,diabetes mellitus,,,,, -8299615,2705,,affects,,Furosemide,,,,acute kidney failure,,,,, -27482854,2706,,disrupts,,Furosemide,,,,Edema,,,,, -19844878,2707,,disrupts,,Furosemide,,,,Dyspnea,,,,, -24717003,2708,,prevents,,Furosemide,,,,pulmonary edema,,,,, -22953098,2709,,prevents,,Furosemide,,,,Dyspnea,,,,, -21527038,2710,,prevents,,Furosemide,,,,schizophrenia,,,,, -20769925,2711,,prevents,,Furosemide,,,,bronchopulmonary dysplasia,,,,, -12415888,2712,,prevents,,Furosemide,,,,kidney disorder,,,,, -11075685,2713,,prevents,,Furosemide,,,,hypertensive disorder,,,,, -9165205,2714,,prevents,,Furosemide,,,,Edema,,,,, -8733555,2715,,prevents,,Furosemide,,,,syndromic disease,,,,, -7901682,2716,,prevents,,Furosemide,,,,kidney failure,,,,, -24388792,2717,,predisposes,,Furosemide,,,,acute kidney failure,,,,, -23800241,2718,,predisposes,,Furosemide,,,,myocardial infarction,,,,, -21525697,2719,,predisposes,,Furosemide,,,,atherosclerosis,,,,, -16660855,2720,,predisposes,,Furosemide,,,,kidney disorder,,,,, -19565633,2721,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, -14176438,2722,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, -15189827,2723,,affects,,Nabumetone,,,,osteoarthritis,,,,, -9219116,2724,,affects,,Nabumetone,,,,Cyclooxygenase 2,,,,, -11784119,2725,,related to,,Selegiline,,,,Parkinson disease,,,,, -7091710,2726,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, -7091710,2727,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, -26670675,2728,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, -26670675,2729,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, -13016594,2730,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, -26762387,2731,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, -27251718,2732,,causes,,Selegiline,,,,depressive disorder,,,,, -18216942,2733,,causes,,Selegiline,,,,Parkinson disease,,,,, -8842901,2734,,affects,,Selegiline,,,,Parkinson disease,,,,, -7091708,2735,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, -8615177,2736,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, -11022843,2737,,disrupts,,Selegiline,,,,Parkinson disease,,,,, -8202759,2738,,prevents,,Selegiline,,,,depressive disorder,,,,, -7205408,2739,,prevents,,Selegiline,,,,Parkinson disease,,,,, -21543223,2740,,causes,,Bumetanide,,,,pervasive developmental disorder,,,,, -22325231,2741,,affects,,Bumetanide,,,,pervasive developmental disorder,,,,, -20190253,2742,,affects,,Bumetanide,,,,autism spectrum disorder,,,,, -16914848,2743,,prevents,,Bumetanide,,,,autism spectrum disorder,,,,, -11943751,2744,,related to,,D-Glucosamine,,,,breast neoplasm,,,,, -7809202,2745,,related to,,D-Glucosamine,,,,osteoarthritis,,,,, -27619077,2746,,causes,,D-Glucosamine,,,,obesity disorder,,,,, -18633463,2747,,causes,,D-Glucosamine,,,,osteoarthritis,,,,, -9909825,2748,,affects,,D-Glucosamine,,,,osteoarthritis,,,,, -8968754,2749,,affects,,D-Glucosamine,,,,obesity disorder,,,,, -13460623,2750,,disrupts,,D-Glucosamine,,,,osteoarthritis,,,,, -11817662,2751,,prevents,,D-Glucosamine,,,,osteoarthritis,,,,, -25749858,2752,,causes,,Torsemide,,,,hypertensive disorder,,,,, -26478746,2753,,affects,,Torsemide,,,,hypertensive disorder,,,,, -13754465,2754,,affects,,Torsemide,,,,hypertensive disorder,,,,, -24478260,2755,,related to,,Leuprorelin,,,,infertility disorder,,,,, -22375547,2756,,related to,,Leuprorelin,,,,neoplasm,,,,, -17696905,2757,,related to,,Leuprorelin,,,,leiomyoma,,,,, -16368292,2758,,related to,,Leuprorelin,,,,prostate cancer,,,,, -15413679,2759,,related to,,Leuprorelin,,,,endometriosis,,,,, -9878755,2760,,causes,,Leuprorelin,,,,hypogonadism,,,,, -7418968,2761,,causes,,Leuprorelin,,,,neoplasm,,,,, -27571709,2762,,affects,,Leuprorelin,,,,prostate cancer,,,,, -27571708,2763,,affects,,Leuprorelin,,,,endometriosis,,,,, -26547561,2764,,affects,,Leuprorelin,,,,endometriosis,,,,, -26152029,2765,,affects,,Leuprorelin,,,,prostate cancer,,,,, -27542556,2766,,prevents,,Leuprorelin,,,,neoplasm,,,,, -12402472,2767,,prevents,,Leuprorelin,,,,Pain,,,,, -7814590,2768,,subclass of,,Sodium Bicarbonate,,,,Electrolytes,,,,, -26447678,2769,,related to,,Sodium Bicarbonate,,,,cystic fibrosis,,,,, -26270339,2770,,related to,,Sodium Bicarbonate,,,,kidney failure,,,,, -20718850,2771,,related to,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -15047625,2772,,related to,,Sodium Bicarbonate,,,,Pain,,,,, -14688492,2773,,related to,,Sodium Bicarbonate,,,,chronic renal failure syndrome,,,,, -13166244,2774,,related to,,Sodium Bicarbonate,,,,kidney disorder,,,,, -12100581,2775,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, -13772853,2776,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, -27495118,2777,,causes,,Sodium Bicarbonate,,,,kidney failure,,,,, -18327883,2778,,causes,,Sodium Bicarbonate,,,,kidney disorder,,,,, -14549296,2779,,causes,,Sodium Bicarbonate,,,,injury,,,,, -8914995,2780,,causes,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -25712033,2781,,affects,,Sodium Bicarbonate,,,,Abnormality of acid-base homeostasis,,,,, -18411502,2782,,affects,,Sodium Bicarbonate,,,,injury,,,,, -17654743,2783,,affects,,Sodium Bicarbonate,,,,kidney disorder,,,,, -12960490,2784,,affects,,Sodium Bicarbonate,,,,Pain,,,,, -8914994,2785,,affects,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -14651482,2786,,disrupts,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -21103228,2787,,prevents,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -13938650,2788,,prevents,,Sodium Bicarbonate,,,,injury,,,,, -11746267,2789,,prevents,,Sodium Bicarbonate,,,,kidney failure,,,,, -11205688,2790,,prevents,,Sodium Bicarbonate,,,,acute kidney failure,,,,, -11205686,2791,,prevents,,Sodium Bicarbonate,,,,kidney disorder,,,,, -14663272,2792,,predisposes,,Sodium Bicarbonate,,,,kidney disorder,,,,, -14542214,2793,,predisposes,,Sodium Bicarbonate,,,,injury,,,,, -17530350,2794,,affects,,Olmesartan medoxomil,,,,diabetic kidney disease,,,,, -12894557,2795,,affects,,Olmesartan medoxomil,,,,atherosclerosis,,,,, -12254737,2796,,affects,,Olmesartan medoxomil,,,,diabetes mellitus,,,,, -15583038,2797,,disrupts,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, -12254736,2798,,disrupts,,Olmesartan medoxomil,,,,proteinuria,,,,, -12254735,2799,,prevents,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, -9359700,2800,,prevents,,Olmesartan medoxomil,,,,atherosclerosis,,,,, -8752749,2801,,related to,,Candesartan,,,,essential hypertension,,,,, -20752265,2802,,causes,,Candesartan,,,,Cognitive impairment,,,,, -14838058,2803,,causes,,Candesartan,,,,hypertensive disorder,,,,, -20512666,2804,,affects,,Candesartan,,,,Cognitive impairment,,,,, -20051167,2805,,affects,,Candesartan,,,,hypertensive disorder,,,,, -19501045,2806,,affects,,Candesartan,,,,Cognitive impairment,,,,, -14118850,2807,,affects,,Candesartan,,,,Left ventricular hypertrophy,,,,, -9919312,2808,,affects,,Candesartan,,,,hypertensive disorder,,,,, -14542524,2809,,disrupts,,Candesartan,,,,Left ventricular hypertrophy,,,,, -9479295,2810,,disrupts,,Candesartan,,,,hypertensive disorder,,,,, -24756017,2811,,prevents,,Candesartan,,,,Cognitive impairment,,,,, -15502429,2812,,prevents,,Candesartan,,,,cardiovascular disorder,,,,, -12994289,2813,,prevents,,Candesartan,,,,Left ventricular hypertrophy,,,,, -12444324,2814,,prevents,,Candesartan,,,,atrial fibrillation,,,,, -12421723,2815,,prevents,,Candesartan,,,,migraine disorder,,,,, -8787605,2816,,prevents,,Candesartan,,,,hypertensive disorder,,,,, -9420113,2817,,related to,,Telmisartan,,,,diabetes mellitus,,,,, -9420112,2818,,related to,,Telmisartan,,,,hypertensive disorder,,,,, -16669618,2819,,causes,,Telmisartan,,,,cardiovascular disorder,,,,, -16637024,2820,,causes,,Telmisartan,,,,hypertensive disorder,,,,, -16559226,2821,,causes,,Telmisartan,,,,myocardial infarction,,,,, -14418892,2822,,causes,,Telmisartan,,,,Albuminuria,,,,, -13301662,2823,,causes,,Telmisartan,,,,diabetes mellitus,,,,, -20835589,2824,,affects,,Telmisartan,,,,diabetic kidney disease,,,,, -17882285,2825,,affects,,Telmisartan,,,,Albuminuria,,,,, -16266744,2826,,affects,,Telmisartan,,,,Albuminuria,,,,, -15802746,2827,,affects,,Telmisartan,,,,diabetes mellitus,,,,, -13992848,2828,,affects,,Telmisartan,,,,diabetes mellitus,,,,, -13861721,2829,,affects,,Telmisartan,,,,type 2 diabetes mellitus,,,,, -13824093,2830,,affects,,Telmisartan,,,,Albuminuria,,,,, -13501012,2831,,affects,,Telmisartan,,,,essential hypertension,,,,, -13178302,2832,,affects,,Telmisartan,,,,hypertensive disorder,,,,, -25051574,2833,,disrupts,,Telmisartan,,,,Alzheimer disease,,,,, -14418891,2834,,disrupts,,Telmisartan,,,,Albuminuria,,,,, -13325686,2835,,disrupts,,Telmisartan,,,,hypertensive disorder,,,,, -21182197,2836,,prevents,,Telmisartan,,,,Alzheimer disease,,,,, -17513403,2837,,prevents,,Telmisartan,,,,myocardial infarction,,,,, -17170882,2838,,prevents,,Telmisartan,,,,type 2 diabetes mellitus,,,,, -13010398,2839,,prevents,,Telmisartan,,,,stroke disorder,,,,, -12278433,2840,,prevents,,Telmisartan,,,,diabetic kidney disease,,,,, -11585228,2841,,prevents,,Telmisartan,,,,diabetes mellitus,,,,, -11585227,2842,,prevents,,Telmisartan,,,,cardiovascular disorder,,,,, -11473935,2843,,prevents,,Telmisartan,,,,hypertensive disorder,,,,, -17028323,2844,,predisposes,,Telmisartan,,,,stroke disorder,,,,, -17028322,2845,,predisposes,,Telmisartan,,,,myocardial infarction,,,,, -21651336,2846,,causes,,Irbesartan,,,,hypertensive disorder,,,,, -19454247,2847,,affects,,Irbesartan,,,,Sepsis,,,,, -13143483,2848,,affects,,Irbesartan,,,,type 2 diabetes mellitus,,,,, -9015828,2849,,affects,,Irbesartan,,,,chronic kidney disease,,,,, -9015827,2850,,affects,,Irbesartan,,,,diabetic kidney disease,,,,, -7812861,2851,,affects,,Irbesartan,,,,acute kidney failure,,,,, -19016605,2852,,disrupts,,Irbesartan,,,,atrial fibrillation,,,,, -11936096,2853,,disrupts,,Irbesartan,,,,hypertensive disorder,,,,, -9297339,2854,,disrupts,,Irbesartan,,,,diabetic kidney disease,,,,, -11467158,2855,,prevents,,Irbesartan,,,,chronic kidney disease,,,,, -9856662,2856,,prevents,,Irbesartan,,,,diabetic kidney disease,,,,, -8753962,2857,,prevents,,Irbesartan,,,,hypertensive disorder,,,,, -15497727,2858,,predisposes,,Irbesartan,,,,cardiovascular disorder,,,,, -12041301,2859,,predisposes,,Irbesartan,,,,IgA glomerulonephritis,,,,, -9459261,2860,,related to,,Eprosartan,,,,essential hypertension,,,,, -8111433,2861,,related to,,Valsartan,,,,essential hypertension,,,,, -18505936,2862,,causes,,Valsartan,,,,myocardial infarction,,,,, -13301661,2863,,causes,,Valsartan,,,,diabetes mellitus,,,,, -18533693,2864,,affects,,Valsartan,,,,hypertensive disorder,,,,, -18130226,2865,,affects,,Valsartan,,,,stroke disorder,,,,, -16609149,2866,,affects,,Valsartan,,,,kidney disorder,,,,, -9837968,2867,,affects,,Valsartan,,,,Abnormal left ventricular function,,,,, -15479686,2868,,disrupts,,Valsartan,,,,type 2 diabetes mellitus,,,,, -11438135,2869,,disrupts,,Valsartan,,,,atherosclerosis,,,,, -20671333,2870,,prevents,,Valsartan,,,,Abnormal left ventricular function,,,,, -15012324,2871,,prevents,,Valsartan,,,,type 2 diabetes mellitus,,,,, -13899819,2872,,prevents,,Valsartan,,,,stroke disorder,,,,, -12374506,2873,,prevents,,Valsartan,,,,diabetes mellitus,,,,, -12038680,2874,,prevents,,Valsartan,,,,myocardial infarction,,,,, -11801448,2875,,prevents,,Valsartan,,,,atrial fibrillation,,,,, -8617185,2876,,prevents,,Valsartan,,,,coronary artery disorder,,,,, -7691192,2877,,prevents,,Valsartan,,,,hypertensive disorder,,,,, -7604460,2878,,prevents,,Valsartan,,,,atherosclerosis,,,,, -21524148,2879,,predisposes,,Valsartan,,,,myocardial infarction,,,,, -11133518,2880,,predisposes,,Valsartan,,,,cardiovascular disorder,,,,, -13065808,2881,,related to,,Losartan,,,,non-alcoholic fatty liver disease,,,,, -12094342,2882,,related to,,Losartan,,,,proteinuria,,,,, -11472713,2883,,related to,,Losartan,,,,kidney disorder,,,,, -10013644,2884,,related to,,Losartan,,,,hypertensive disorder,,,,, -8975375,2885,,related to,,Losartan,,,,IgA glomerulonephritis,,,,, -16215194,2886,,causes,,Losartan,,,,injury,,,,, -15690681,2887,,causes,,Losartan,,,,kidney disorder,,,,, -9749061,2888,,causes,,Losartan,,,,hypertensive disorder,,,,, -7310301,2889,,causes,,Losartan,,,,proteinuria,,,,, -7204638,2890,,causes,,Losartan,,,,Left ventricular hypertrophy,,,,, -26608778,2891,,affects,,Losartan,,,,essential hypertension,,,,, -24425437,2892,,affects,,Losartan,,,,cystic fibrosis,,,,, -21888728,2893,,affects,,Losartan,,,,proteinuria,,,,, -20488125,2894,,affects,,Losartan,,,,hypertensive disorder,,,,, -19990804,2895,,affects,,Losartan,,,,aortic valve insufficiency,,,,, -18707849,2896,,affects,,Losartan,,,,hypertrophic cardiomyopathy,,,,, -16976701,2897,,affects,,Losartan,,,,IgA glomerulonephritis,,,,, -13986638,2898,,affects,,Losartan,,,,adult acute respiratory distress syndrome,,,,, -13539739,2899,,affects,,Losartan,,,,proteinuria,,,,, -13498248,2900,,affects,,Losartan,,,,Inflammation,,,,, -12531070,2901,,affects,,Losartan,,,,Left ventricular hypertrophy,,,,, -10809955,2902,,affects,,Losartan,,,,hypertensive disorder,,,,, -9615315,2903,,affects,,Losartan,,,,diabetic kidney disease,,,,, -9459571,2904,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, -9229634,2905,,affects,,Losartan,,,,kidney disorder,,,,, -8678480,2906,,affects,,Losartan,,,,injury,,,,, -8551167,2907,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, -18715311,2908,,disrupts,,Losartan,,,,breast neoplasm,,,,, -14458903,2909,,disrupts,,Losartan,,,,pancreatic neoplasm,,,,, -13976332,2910,,disrupts,,Losartan,,,,diabetic kidney disease,,,,, -12949848,2911,,disrupts,,Losartan,,,,Inflammation,,,,, -9870082,2912,,disrupts,,Losartan,,,,hypertensive disorder,,,,, -9655766,2913,,disrupts,,Losartan,,,,type 2 diabetes mellitus,,,,, -8325352,2914,,disrupts,,Losartan,,,,Left ventricular hypertrophy,,,,, -7975855,2915,,disrupts,,Losartan,,,,injury,,,,, -7310299,2916,,disrupts,,Losartan,,,,proteinuria,,,,, -21356716,2917,,prevents,,Losartan,,,,post-traumatic stress disorder,,,,, -14540327,2918,,prevents,,Losartan,,,,kidney disorder,,,,, -12407992,2919,,prevents,,Losartan,,,,Inflammation,,,,, -10030687,2920,,prevents,,Losartan,,,,cardiovascular disorder,,,,, -9856661,2921,,prevents,,Losartan,,,,diabetic kidney disease,,,,, -9773800,2922,,prevents,,Losartan,,,,Left ventricular hypertrophy,,,,, -9766007,2923,,prevents,,Losartan,,,,adult acute respiratory distress syndrome,,,,, -9420091,2924,,prevents,,Losartan,,,,Stenosis,,,,, -9077908,2925,,prevents,,Losartan,,,,proteinuria,,,,, -8542944,2926,,prevents,,Losartan,,,,injury,,,,, -7768196,2927,,prevents,,Losartan,,,,hypertensive disorder,,,,, -14272023,2928,,predisposes,,Losartan,,,,kidney disorder,,,,, -12616336,2929,,predisposes,,Losartan,,,,cardiovascular disorder,,,,, -9964252,2930,,predisposes,,Losartan,,,,Left ventricular hypertrophy,,,,, -20586471,2931,,related to,,Dronabinol,,,,multiple sclerosis,,,,, -25459397,2932,,causes,,Dronabinol,,,,cannabis dependence,,,,, -22027243,2933,,causes,,Dronabinol,,,,Nausea,,,,, -17252204,2934,,causes,,Dronabinol,,,,schizophrenia,,,,, -12205989,2935,,causes,,Dronabinol,,,,Cognitive impairment,,,,, -27448088,2936,,affects,,Dronabinol,,,,Anorexia,,,,, -25890458,2937,,affects,,Dronabinol,,,,Nausea,,,,, -21879717,2938,,affects,,Dronabinol,,,,anorexia nervosa,,,,, -20855895,2939,,affects,,Dronabinol,,,,neoplasm,,,,, -19991701,2940,,affects,,Dronabinol,,,,obstructive sleep apnea syndrome,,,,, -19474044,2941,,affects,,Dronabinol,,,,multiple sclerosis,,,,, -16547908,2942,,affects,,Dronabinol,,,,schizophrenia,,,,, -14443952,2943,,affects,,Dronabinol,,,,opiate dependence,,,,, -13958866,2944,,affects,,Dronabinol,,,,Cognitive impairment,,,,, -13933776,2945,,affects,,Dronabinol,,,,schizophrenia,,,,, -11304843,2946,,affects,,Dronabinol,,,,neuralgia,,,,, -11058493,2947,,affects,,Dronabinol,,,,Pain,,,,, -24013541,2948,,disrupts,,Dronabinol,,,,Pain,,,,, -17477155,2949,,disrupts,,Dronabinol,,,,HIV infectious disease,,,,, -11615857,2950,,disrupts,,Dronabinol,,,,Nausea,,,,, -25196408,2951,,prevents,,Dronabinol,,,,dementia,,,,, -25026370,2952,,prevents,,Dronabinol,,,,neuralgia,,,,, -18579580,2953,,prevents,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, -18554637,2954,,prevents,,Dronabinol,,,,Nausea,,,,, -17477149,2955,,prevents,,Dronabinol,,,,HIV infectious disease,,,,, -9671016,2956,,prevents,,Dronabinol,,,,Pain,,,,, -22976957,2957,,predisposes,,Dronabinol,,,,Cognitive impairment,,,,, -18579581,2958,,predisposes,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, -26722658,2959,,affects,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, -26699974,2960,,affects,,Cesamet,,,,Nausea,,,,, -19460580,2961,,prevents,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, -25552574,2962,,related to,,Aprepitant,,,,glioblastoma,,,,, -18054447,2963,,related to,,Aprepitant,,,,Vomiting,,,,, -18054446,2964,,related to,,Aprepitant,,,,Nausea,,,,, -11788538,2965,,causes,,Aprepitant,,,,Vomiting,,,,, -11788537,2966,,causes,,Aprepitant,,,,Nausea,,,,, -23692862,2967,,affects,,Aprepitant,,,,Nausea,,,,, -19750085,2968,,affects,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, -17874842,2969,,affects,,Aprepitant,,,,Vomiting,,,,, -12562288,2970,,affects,,Aprepitant,,,,Nausea,,,,, -11119543,2971,,affects,,Aprepitant,,,,Vomiting,,,,, -19013645,2972,,disrupts,,Aprepitant,,,,HIV infectious disease,,,,, -16125731,2973,,disrupts,,Aprepitant,,,,Vomiting,,,,, -16125730,2974,,disrupts,,Aprepitant,,,,Nausea,,,,, -16513148,2975,,prevents,,Aprepitant,,,,Pruritus,,,,, -15868137,2976,,prevents,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, -10160541,2977,,prevents,,Aprepitant,,,,Vomiting,,,,, -10160540,2978,,prevents,,Aprepitant,,,,Nausea,,,,, -20804596,2979,,predisposes,,Aprepitant,,,,Nausea,,,,, -22122089,2980,,affects,,Neratinib,,,,neoplasm,,,,, -21597229,2981,,related to,,Lapatinib,,,,neoplasm,,,,, -13650844,2982,,related to,,Lapatinib,,,,non-small cell lung carcinoma,,,,, -18268107,2983,,affects,,Lapatinib,,,,neoplasm,,,,, -15442238,2984,,affects,,Lapatinib,,,,breast neoplasm,,,,, -14691634,2985,,affects,,Lapatinib,,,,neoplasm,,,,, -17546445,2986,,disrupts,,Lapatinib,,,,neoplasm,,,,, -19410918,2987,,prevents,,Lapatinib,,,,breast neoplasm,,,,, -19317295,2988,,prevents,,Lapatinib,,,,neoplasm,,,,, -16643911,2989,,predisposes,,Lapatinib,,,,neoplasm,,,,, -24360220,2990,,related to,,Nifurtimox,,,,human African trypanosomiasis,,,,, -25977066,2991,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, -25977066,2992,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, -25822629,2993,,causes,,Nifurtimox,,,,Chagas disease,,,,, -21140520,2994,,affects,,Nifurtimox,,,,neuroblastoma,,,,, -19390598,2995,,affects,,Nifurtimox,,,,trypanosomiasis,,,,, -18236131,2996,,affects,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, -21140519,2997,,disrupts,,Nifurtimox,,,,neuroblastoma,,,,, -16729888,2998,,prevents,,Nifurtimox,,,,Chagas disease,,,,, -8359719,2999,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -8359719,3000,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -21506050,3001,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -16350865,3002,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -26982963,3003,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, -14891197,3004,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, -13216168,3005,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, -9844335,3006,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, -11447618,3007,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, -11253841,3008,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, -8806634,3009,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, -26997768,3010,,affects,,Metopimazine,,,,Nausea,,,,, -12265728,3011,,prevents,,Metopimazine,,,,Nausea,,,,, -27200379,3012,,related to,,Lincomycin,,,,osteomyelitis,,,,, -9905527,3013,,causes,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -9905522,3014,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -8547552,3015,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -11060423,3016,,prevents,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -20876966,3017,,related to,,Ketorolac,,,,migraine disorder,,,,, -27688883,3018,,causes,,Ketorolac,,,,Inflammation,,,,, -21368479,3019,,causes,,Ketorolac,,,,pancreatitis,,,,, -19597016,3020,,causes,,Ketorolac,,,,Miosis,,,,, -12090892,3021,,causes,,Ketorolac,,,,Pain,,,,, -20018980,3022,,affects,,Ketorolac,,,,breast neoplasm,,,,, -19245410,3023,,affects,,Ketorolac,,,,Miosis,,,,, -9719257,3024,,affects,,Ketorolac,,,,Pain,,,,, -24071071,3025,,disrupts,,Ketorolac,,,,Headache,,,,, -24029444,3026,,disrupts,,Ketorolac,,,,Inflammation,,,,, -11549492,3027,,disrupts,,Ketorolac,,,,Pain,,,,, -11362008,3028,,disrupts,,Ketorolac,,,,Back pain,,,,, -24306825,3029,,prevents,,Ketorolac,,,,Renal Colic,,,,, -23612322,3030,,prevents,,Ketorolac,,,,Chronic pain,,,,, -20717559,3031,,prevents,,Ketorolac,,,,injury,,,,, -11362007,3032,,prevents,,Ketorolac,,,,Back pain,,,,, -11361661,3033,,prevents,,Ketorolac,,,,Inflammation,,,,, -11043378,3034,,prevents,,Ketorolac,,,,Headache,,,,, -7985904,3035,,prevents,,Ketorolac,,,,Pain,,,,, -20028754,3036,,predisposes,,Ketorolac,,,,injury,,,,, -25929768,3037,,related to,,Sulfadiazine,,,,congenital toxoplasmosis,,,,, -16546748,3038,,related to,,Sulfadiazine,,,,chorioretinitis,,,,, -27660461,3039,,causes,,Sulfamethoxazole,,,,pneumonia,,,,, -24328685,3040,,causes,,Sulfamethoxazole,,,,kidney disorder,,,,, -14835537,3041,,affects,,Sulfamethoxazole,,,,cystic fibrosis,,,,, -12226918,3042,,affects,,Sulfamethoxazole,,,,ocular toxoplasmosis,,,,, -26634163,3043,,prevents,,Sulfamethoxazole,,,,bacterial infectious disease,,,,, -23781290,3044,,prevents,,Sulfamethoxazole,,,,Infection,,,,, -22185408,3045,,prevents,,Sulfamethoxazole,,,,pneumocystosis,,,,, -21716989,3046,,affects,,Glycyrrhizic acid,,,,osteoarthritis,,,,, -21716987,3047,,disrupts,,Glycyrrhizic acid,,,,osteoarthritis,,,,, -13246285,3048,,related to,,Ciclesonide,,,,perennial allergic rhinitis,,,,, -13246284,3049,,related to,,Ciclesonide,,,,seasonal allergic rhinitis,,,,, -10789097,3050,,related to,,Ciclesonide,,,,asthma,,,,, -13334776,3051,,causes,,Ciclesonide,,,,asthma,,,,, -13603690,3052,,affects,,Ciclesonide,,,,asthma,,,,, -26135729,3053,,related to,,Flunisolide,,,,perennial allergic rhinitis,,,,, -16438918,3054,,related to,,Flunisolide,,,,rhinitis,,,,, -7778368,3055,,related to,,Flunisolide,,,,asthma,,,,, -12189287,3056,,prevents,,Flunisolide,,,,Nasal congestion,,,,, -27725383,3057,,related to,,Etoposide,,,,hepatoblastoma,,,,, -27360363,3058,,related to,,Etoposide,,,,ependymoma,,,,, -27062931,3059,,related to,,Etoposide,,,,supratentorial primitive neuroectodermal tumor,,,,, -26965210,3060,,related to,,Etoposide,,,,kidney Wilms tumor,,,,, -26632944,3061,,related to,,Etoposide,,,,HIV infectious disease,,,,, -22727077,3062,,related to,,Etoposide,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -21142004,3063,,related to,,Etoposide,,,,AIDS,,,,, -20988037,3064,,related to,,Etoposide,,,,retinoblastoma,,,,, -20394132,3065,,related to,,Etoposide,,,,B-cell neoplasm,,,,, -19900770,3066,,related to,,Etoposide,,,,myelodysplastic syndrome,,,,, -18768176,3067,,related to,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, -17380085,3068,,related to,,Etoposide,,,,Kaposi's sarcoma,,,,, -17284305,3069,,related to,,Etoposide,,,,bone osteosarcoma,,,,, -17191209,3070,,related to,,Etoposide,,,,hepatocellular carcinoma,,,,, -17136035,3071,,related to,,Etoposide,,,,diffuse large B-cell lymphoma,,,,, -16406847,3072,,related to,,Etoposide,,,,neuroendocrine carcinoma,,,,, -16067960,3073,,related to,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, -15501025,3074,,related to,,Etoposide,,,,brain cancer,,,,, -15141728,3075,,related to,,Etoposide,,,,testicular cancer,,,,, -15031494,3076,,related to,,Etoposide,,,,lymphoid leukemia,,,,, -14511230,3077,,related to,,Etoposide,,,,glioblastoma,,,,, -14453465,3078,,related to,,Etoposide,,,,T-cell non-Hodgkin lymphoma,,,,, -13764189,3079,,related to,,Etoposide,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -12298091,3080,,related to,,Etoposide,,,,breast neoplasm,,,,, -11028194,3081,,related to,,Etoposide,,,,acute lymphoblastic leukemia,,,,, -10672040,3082,,related to,,Etoposide,,,,Ewing sarcoma,,,,, -10503115,3083,,related to,,Etoposide,,,,kidney cancer,,,,, -10441577,3084,,related to,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, -10410657,3085,,related to,,Etoposide,,,,neutropenia,,,,, -10182075,3086,,related to,,Etoposide,,,,non-Hodgkin lymphoma,,,,, -10161953,3087,,related to,,Etoposide,,,,squamous cell carcinoma,,,,, -9231982,3088,,related to,,Etoposide,,,,carcinoma,,,,, -9157972,3089,,related to,,Etoposide,,,,thymoma,,,,, -9138703,3090,,related to,,Etoposide,,,,ovarian cancer,,,,, -9115115,3091,,related to,,Etoposide,,,,sarcoma,,,,, -9024985,3092,,related to,,Etoposide,,,,leukemia,,,,, -9008448,3093,,related to,,Etoposide,,,,Hodgkins lymphoma,,,,, -9006645,3094,,related to,,Etoposide,,,,neuroblastoma,,,,, -8074798,3095,,related to,,Etoposide,,,,medulloblastoma,,,,, -8048523,3096,,related to,,Etoposide,,,,lymphoma,,,,, -7998504,3097,,related to,,Etoposide,,,,plasma cell myeloma,,,,, -7989979,3098,,related to,,Etoposide,,,,neoplasm,,,,, -7896801,3099,,related to,,Etoposide,,,,adult T-cell leukemia/lymphoma,,,,, -7845509,3100,,related to,,Etoposide,,,,glioma,,,,, -7810052,3101,,related to,,Etoposide,,,,castration-resistant prostate carcinoma,,,,, -7711547,3102,,related to,,Etoposide,,,,acute myeloid leukemia,,,,, -7319060,3103,,related to,,Etoposide,,,,small cell lung carcinoma,,,,, -7200681,3104,,related to,,Etoposide,,,,non-small cell lung carcinoma,,,,, -23328204,3105,,causes,,Etoposide,,,,small cell lung carcinoma,,,,, -12215704,3106,,causes,,Etoposide,,,,neoplasm,,,,, -8706370,3107,,causes,,Etoposide,,,,neutropenia,,,,, -7869845,3108,,causes,,Etoposide,,,,leukemia,,,,, -7642766,3109,,causes,,Etoposide,,,,acute myeloid leukemia,,,,, -27374335,3110,,affects,,Etoposide,,,,retinoblastoma,,,,, -26960810,3111,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, -25269562,3112,,affects,,Etoposide,,,,hemophagocytic syndrome,,,,, -23238600,3113,,affects,,Etoposide,,,,choriocarcinoma,,,,, -18166706,3114,,affects,,Etoposide,,,,neuroblastoma,,,,, -17967080,3115,,affects,,Etoposide,,,,leukemia,,,,, -17160632,3116,,affects,,Etoposide,,,,carcinoma,,,,, -16724406,3117,,affects,,Etoposide,,,,neoplasm,,,,, -16425822,3118,,affects,,Etoposide,,,,leukemia,,,,, -15965763,3119,,affects,,Etoposide,,,,testicular cancer,,,,, -12798395,3120,,affects,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, -11699750,3121,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, -11396769,3122,,affects,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, -9913818,3123,,affects,,Etoposide,,,,acute erythroid leukemia,,,,, -9397866,3124,,affects,,Etoposide,,,,fallopian tube neoplasm,,,,, -9293530,3125,,affects,,Etoposide,,,,carcinoid tumor,,,,, -8200378,3126,,affects,,Etoposide,,,,neoplasm,,,,, -8003315,3127,,affects,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, -7908520,3128,,affects,,Etoposide,,,,B-cell neoplasm,,,,, -24115005,3129,,disrupts,,Etoposide,,,,small cell lung carcinoma,,,,, -17149618,3130,,disrupts,,Etoposide,,,,hemophagocytic syndrome,,,,, -16511954,3131,,disrupts,,Etoposide,,,,glioblastoma,,,,, -16039903,3132,,disrupts,,Etoposide,,,,neoplasm,,,,, -14383828,3133,,disrupts,,Etoposide,,,,bone osteosarcoma,,,,, -9134229,3134,,prevents,,Etoposide,,,,neoplasm,,,,, -22634859,3135,,predisposes,,Etoposide,,,,neoplasm,,,,, -18673787,3136,,predisposes,,Etoposide,,,,brain cancer,,,,, -16345738,3137,,predisposes,,Etoposide,,,,myelodysplastic syndrome,,,,, -16345737,3138,,predisposes,,Etoposide,,,,acute myeloid leukemia,,,,, -10333072,3139,,predisposes,,Etoposide,,,,leukemia,,,,, -16677028,3140,,related to,,Teniposide,,,,neoplasm,,,,, -10688707,3141,,related to,,Teniposide,,,,lymphoma,,,,, -10688706,3142,,related to,,Teniposide,,,,leukemia,,,,, -27095076,3143,,affects,,Teniposide,,,,leukemia,,,,, -26849066,3144,,predisposes,,Teniposide,,,,leukemia,,,,, -18768362,3145,,related to,,Urofollitropin,,,,hypogonadism,,,,, -18095820,3146,,related to,,Urofollitropin,,,,primary ovarian failure,,,,, -9960851,3147,,related to,,Urofollitropin,,,,anovulation,,,,, -9716197,3148,,related to,,Urofollitropin,,,,female infertility,,,,, -8496709,3149,,related to,,Urofollitropin,,,,infertility disorder,,,,, -8454088,3150,,related to,,Urofollitropin,,,,male infertility,,,,, -8378642,3151,,related to,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -8205307,3152,,related to,,Urofollitropin,,,,azoospermia,,,,, -14878529,3153,,related to,,Urofollitropin,,,,female infertility,,,,, -9422493,3154,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -9422493,3155,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -10444908,3156,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -10444908,3157,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7103614,3158,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7103614,3159,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7302412,3160,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7606444,3161,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -21372974,3162,,causes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -16723493,3163,,causes,,Urofollitropin,,,,hypogonadism,,,,, -16322495,3164,,causes,,Urofollitropin,,,,azoospermia,,,,, -9453052,3165,,causes,,Urofollitropin,,,,primary ovarian failure,,,,, -8923757,3166,,causes,,Urofollitropin,,,,Pregnancy,,,,, -8815215,3167,,causes,,Urofollitropin,,,,anovulation,,,,, -8590972,3168,,causes,,Urofollitropin,,,,male infertility,,,,, -8270576,3169,,causes,,Urofollitropin,,,,infertility disorder,,,,, -19357829,3170,,affects,,Urofollitropin,,,,gonadal disorder,,,,, -15865492,3171,,affects,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -14984090,3172,,affects,,Urofollitropin,,,,male infertility,,,,, -13249247,3173,,affects,,Urofollitropin,,,,Pregnancy,,,,, -10980447,3174,,affects,,Urofollitropin,,,,Pregnancy,,,,, -8590971,3175,,affects,,Urofollitropin,,,,male infertility,,,,, -7302415,3176,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -9844029,3177,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -27587327,3178,,produces,,Urofollitropin,,,,primary ovarian failure,,,,, -20465917,3179,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -20465917,3180,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -8502213,3181,,produces,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -20569186,3182,,disrupts,,Urofollitropin,,,,Pregnancy,,,,, -11195885,3183,,prevents,,Urofollitropin,,,,azoospermia,,,,, -17502146,3184,,predisposes,,Urofollitropin,,,,azoospermia,,,,, -16417247,3185,,predisposes,,Urofollitropin,,,,anovulation,,,,, -16278695,3186,,predisposes,,Urofollitropin,,,,infertility disorder,,,,, -15110465,3187,,predisposes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -7379891,3188,,predisposes,,Urofollitropin,,,,primary ovarian failure,,,,, -23895216,3189,,affects,,Ivacaftor,,,,cystic fibrosis,,,,, -20354463,3190,,related to,,Nitric oxide,,,,ST-elevation myocardial infarction,,,,, -17273075,3191,,related to,,Nitric oxide,,,,bronchiolitis,,,,, -15880296,3192,,related to,,Nitric oxide,,,,Diabetic Foot,,,,, -14910010,3193,,related to,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, -14573099,3194,,related to,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, -11752178,3195,,related to,,Nitric oxide,,,,cutaneous leishmaniasis,,,,, -9816415,3196,,related to,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, -9774015,3197,,related to,,Nitric oxide,,,,respiratory system disorder,,,,, -8707490,3198,,related to,,Nitric oxide,,,,myocardial infarction,,,,, -8593326,3199,,related to,,Nitric oxide,,,,neuralgia,,,,, -8476870,3200,,related to,,Nitric oxide,,,,lung disorder,,,,, -8350800,3201,,related to,,Nitric oxide,,,,opiate dependence,,,,, -8343542,3202,,related to,,Nitric oxide,,,,Varicose Ulcer,,,,, -8057943,3203,,related to,,Nitric oxide,,,,malaria,,,,, -8040944,3204,,related to,,Nitric oxide,,,,sickle cell anemia,,,,, -7963930,3205,,related to,,Nitric oxide,,,,cystic fibrosis,,,,, -7923041,3206,,related to,,Nitric oxide,,,,brain injury,,,,, -7788094,3207,,related to,,Nitric oxide,,,,myocardial ischemia,,,,, -7738003,3208,,related to,,Nitric oxide,,,,Hypoxemia,,,,, -7725812,3209,,related to,,Nitric oxide,,,,Premature birth,,,,, -7657450,3210,,related to,,Nitric oxide,,,,pulmonary embolism,,,,, -7539810,3211,,related to,,Nitric oxide,,,,stroke disorder,,,,, -7481315,3212,,related to,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -7449413,3213,,related to,,Nitric oxide,,,,respiratory failure,,,,, -7439172,3214,,related to,,Nitric oxide,,,,neoplasm,,,,, -7418030,3215,,related to,,Nitric oxide,,,,acute kidney failure,,,,, -7373096,3216,,related to,,Nitric oxide,,,,brain ischemia,,,,, -7345317,3217,,related to,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, -7242606,3218,,related to,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -7159413,3219,,related to,,Nitric oxide,,,,Sepsis,,,,, -7145311,3220,,related to,,Nitric oxide,,,,Inflammation,,,,, -7091337,3221,,related to,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -14184908,3222,,related to,,Nitric oxide,,,,Inflammation,,,,, -27698007,3223,,causes,,Nitric oxide,,,,lung disorder,,,,, -23636922,3224,,causes,,Nitric oxide,,,,Infection,,,,, -22013082,3225,,causes,,Nitric oxide,,,,sickle cell anemia,,,,, -21447838,3226,,causes,,Nitric oxide,,,,respiratory system disorder,,,,, -14028136,3227,,causes,,Nitric oxide,,,,stroke disorder,,,,, -12046903,3228,,causes,,Nitric oxide,,,,cystic fibrosis,,,,, -11887505,3229,,causes,,Nitric oxide,,,,myocardial ischemia,,,,, -11842330,3230,,causes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -11556568,3231,,causes,,Nitric oxide,,,,acute kidney failure,,,,, -11353052,3232,,causes,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -9962165,3233,,causes,,Nitric oxide,,,,malaria,,,,, -9795722,3234,,causes,,Nitric oxide,,,,neuralgia,,,,, -9068211,3235,,causes,,Nitric oxide,,,,pneumonia,,,,, -8934561,3236,,causes,,Nitric oxide,,,,brain injury,,,,, -8855613,3237,,causes,,Nitric oxide,,,,neoplasm,,,,, -8834736,3238,,causes,,Nitric oxide,,,,myocardial infarction,,,,, -8346309,3239,,causes,,Nitric oxide,,,,Premature birth,,,,, -8185371,3240,,causes,,Nitric oxide,,,,Inflammation,,,,, -8037779,3241,,causes,,Nitric oxide,,,,brain ischemia,,,,, -7409857,3242,,causes,,Nitric oxide,,,,Sepsis,,,,, -7184490,3243,,causes,,Nitric oxide,,,,Hypoxemia,,,,, -27626134,3244,,affects,,Nitric oxide,,,,cystic fibrosis,,,,, -27208311,3245,,affects,,Nitric oxide,,,,opiate dependence,,,,, -27058878,3246,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, -20413999,3247,,affects,,Nitric oxide,,,,brain injury,,,,, -19764415,3248,,affects,,Nitric oxide,,,,pneumonia,,,,, -18632674,3249,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, -17798838,3250,,affects,,Nitric oxide,,,,neuralgia,,,,, -17030125,3251,,affects,,Nitric oxide,,,,bronchiolitis,,,,, -12566083,3252,,affects,,Nitric oxide,,,,respiratory system disorder,,,,, -11778681,3253,,affects,,Nitric oxide,,,,stroke disorder,,,,, -11521495,3254,,affects,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, -11353389,3255,,affects,,Nitric oxide,,,,myocardial infarction,,,,, -10403969,3256,,affects,,Nitric oxide,,,,anemia,,,,, -10222313,3257,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -10099288,3258,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, -10018002,3259,,affects,,Nitric oxide,,,,acute kidney failure,,,,, -10008267,3260,,affects,,Nitric oxide,,,,lung disorder,,,,, -9982988,3261,,affects,,Nitric oxide,,,,respiratory failure,,,,, -9910920,3262,,affects,,Nitric oxide,,,,brain ischemia,,,,, -9742582,3263,,affects,,Nitric oxide,,,,stroke disorder,,,,, -9649727,3264,,affects,,Nitric oxide,,,,neoplasm,,,,, -9102608,3265,,affects,,Nitric oxide,,,,Hypoxemia,,,,, -9095187,3266,,affects,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, -8891949,3267,,affects,,Nitric oxide,,,,Sepsis,,,,, -8832872,3268,,affects,,Nitric oxide,,,,pneumonia,,,,, -8646255,3269,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, -8473168,3270,,affects,,Nitric oxide,,,,neoplasm,,,,, -8202584,3271,,affects,,Nitric oxide,,,,Sepsis,,,,, -8139693,3272,,affects,,Nitric oxide,,,,brain injury,,,,, -7935763,3273,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -7896362,3274,,affects,,Nitric oxide,,,,Inflammation,,,,, -7780898,3275,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -7712088,3276,,affects,,Nitric oxide,,,,Hypoxemia,,,,, -7542916,3277,,affects,,Nitric oxide,,,,anemia,,,,, -7169788,3278,,affects,,Nitric oxide,,,,Inflammation,,,,, -7164340,3279,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -7094195,3280,,affects,,Nitric oxide,,,,malaria,,,,, -20359925,3281,,produces,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -20299429,3282,,produces,,Nitric oxide,,,,pneumonia,,,,, -17925357,3283,,produces,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, -15219259,3284,,produces,,Nitric oxide,,,,Premature birth,,,,, -13106727,3285,,produces,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -12774415,3286,,produces,,Nitric oxide,,,,stroke disorder,,,,, -12205025,3287,,produces,,Nitric oxide,,,,Varicose Ulcer,,,,, -11786457,3288,,produces,,Nitric oxide,,,,brain ischemia,,,,, -9816411,3289,,produces,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, -8745644,3290,,produces,,Nitric oxide,,,,sickle cell anemia,,,,, -8339020,3291,,produces,,Nitric oxide,,,,acute kidney failure,,,,, -7963932,3292,,produces,,Nitric oxide,,,,cystic fibrosis,,,,, -7644756,3293,,produces,,Nitric oxide,,,,anemia,,,,, -7555266,3294,,produces,,Nitric oxide,,,,myocardial ischemia,,,,, -7511323,3295,,produces,,Nitric oxide,,,,myocardial infarction,,,,, -7507297,3296,,produces,,Nitric oxide,,,,Inflammation,,,,, -7461061,3297,,produces,,Nitric oxide,,,,Hypoxemia,,,,, -7435212,3298,,produces,,Nitric oxide,,,,neoplasm,,,,, -7390889,3299,,produces,,Nitric oxide,,,,Sepsis,,,,, -7094197,3300,,produces,,Nitric oxide,,,,malaria,,,,, -26705109,3301,,disrupts,,Nitric oxide,,,,anemia,,,,, -19923810,3302,,disrupts,,Nitric oxide,,,,stroke disorder,,,,, -14786185,3303,,disrupts,,Nitric oxide,,,,Sepsis,,,,, -12247489,3304,,disrupts,,Nitric oxide,,,,sickle cell anemia,,,,, -11088644,3305,,disrupts,,Nitric oxide,,,,cystic fibrosis,,,,, -10963665,3306,,disrupts,,Nitric oxide,,,,neoplasm,,,,, -10158293,3307,,disrupts,,Nitric oxide,,,,myocardial ischemia,,,,, -9091818,3308,,disrupts,,Nitric oxide,,,,respiratory failure,,,,, -8577648,3309,,disrupts,,Nitric oxide,,,,Inflammation,,,,, -7822328,3310,,disrupts,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -7750750,3311,,disrupts,,Nitric oxide,,,,myocardial infarction,,,,, -7555296,3312,,disrupts,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -7358959,3313,,disrupts,,Nitric oxide,,,,Hypoxemia,,,,, -26913950,3314,,prevents,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -25277893,3315,,prevents,,Nitric oxide,,,,neuralgia,,,,, -22898445,3316,,prevents,,Nitric oxide,,,,Infection,,,,, -21669107,3317,,prevents,,Nitric oxide,,,,neoplasm,,,,, -21628822,3318,,prevents,,Nitric oxide,,,,Hypoxemia,,,,, -21494876,3319,,prevents,,Nitric oxide,,,,Inflammation,,,,, -21062009,3320,,prevents,,Nitric oxide,,,,pulmonary embolism,,,,, -16675253,3321,,prevents,,Nitric oxide,,,,stroke disorder,,,,, -13634130,3322,,prevents,,Nitric oxide,,,,sickle cell anemia,,,,, -11584828,3323,,prevents,,Nitric oxide,,,,brain ischemia,,,,, -11450951,3324,,prevents,,Nitric oxide,,,,myocardial infarction,,,,, -10887585,3325,,prevents,,Nitric oxide,,,,pneumonia,,,,, -9990816,3326,,prevents,,Nitric oxide,,,,acute kidney failure,,,,, -9464831,3327,,prevents,,Nitric oxide,,,,myocardial ischemia,,,,, -8988568,3328,,prevents,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -8396830,3329,,prevents,,Nitric oxide,,,,cystic fibrosis,,,,, -8224065,3330,,prevents,,Nitric oxide,,,,brain injury,,,,, -8045867,3331,,prevents,,Nitric oxide,,,,lung disorder,,,,, -7996843,3332,,prevents,,Nitric oxide,,,,Sepsis,,,,, -7713281,3333,,prevents,,Nitric oxide,,,,respiratory failure,,,,, -7103253,3334,,prevents,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -27558971,3335,,exacerbates,,Nitric oxide,,,,myocardial ischemia,,,,, -26883794,3336,,exacerbates,,Nitric oxide,,,,acute kidney failure,,,,, -24530593,3337,,exacerbates,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -23305196,3338,,predisposes,,Nitric oxide,,,,cystic fibrosis,,,,, -18515843,3339,,predisposes,,Nitric oxide,,,,malaria,,,,, -17339126,3340,,predisposes,,Nitric oxide,,,,stroke disorder,,,,, -17303048,3341,,predisposes,,Nitric oxide,,,,brain ischemia,,,,, -16438716,3342,,predisposes,,Nitric oxide,,,,respiratory system disorder,,,,, -16061041,3343,,predisposes,,Nitric oxide,,,,lung disorder,,,,, -15696584,3344,,predisposes,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -13236015,3345,,predisposes,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, -12163328,3346,,predisposes,,Nitric oxide,,,,acute kidney failure,,,,, -12068938,3347,,predisposes,,Nitric oxide,,,,neuralgia,,,,, -11569688,3348,,predisposes,,Nitric oxide,,,,Premature birth,,,,, -9326529,3349,,predisposes,,Nitric oxide,,,,brain injury,,,,, -8098085,3350,,predisposes,,Nitric oxide,,,,neoplasm,,,,, -7895713,3351,,predisposes,,Nitric oxide,,,,pneumonia,,,,, -7863118,3352,,predisposes,,Nitric oxide,,,,Hypoxemia,,,,, -7644760,3353,,predisposes,,Nitric oxide,,,,anemia,,,,, -7373094,3354,,predisposes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -7119398,3355,,predisposes,,Nitric oxide,,,,Inflammation,,,,, -18948956,3356,,related to,,CHORIOGONADOTROPIN ALFA,,,,ovarian hyperstimulation syndrome,,,,, -10437081,3357,,related to,,CHORIONIC GONADOTROPIN,,,,hypogonadism,,,,, -10427260,3358,,related to,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, -25953720,3359,,causes,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, -12680602,3360,,causes,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -19382665,3361,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -10661395,3362,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -11878666,3363,,produces,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -19257969,3364,,causes,,Triclosan,,,,allergic disease,,,,, -17886883,3365,,affects,,Triclosan,,,,gingivitis,,,,, -9651026,3366,,disrupts,,Triclosan,,,,gingivitis,,,,, -16053270,3367,,prevents,,Triclosan,,,,allergic disease,,,,, -20585436,3368,,affects,,Povidone iodine,,,,stomatitis,,,,, -22182083,3369,,prevents,,Povidone iodine,,,,Infection,,,,, -22061199,3370,,prevents,,Povidone iodine,,,,dental caries,,,,, -20053240,3371,,prevents,,Povidone iodine,,,,keratitis,,,,, -25268747,3372,,related to,,Vinblastine,,,,acute myeloid leukemia,,,,, -24601120,3373,,related to,,Vinblastine,,,,leukemia,,,,, -17518639,3374,,related to,,Vinblastine,,,,testicular cancer,,,,, -11295996,3375,,related to,,Vinblastine,,,,melanoma,,,,, -10629211,3376,,related to,,Vinblastine,,,,castration-resistant prostate carcinoma,,,,, -9405598,3377,,related to,,Vinblastine,,,,glioma,,,,, -8887641,3378,,related to,,Vinblastine,,,,neoplasm,,,,, -8831546,3379,,related to,,Vinblastine,,,,renal cell carcinoma,,,,, -8248825,3380,,related to,,Vinblastine,,,,lymphoma,,,,, -8201846,3381,,related to,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, -7111310,3382,,related to,,Vinblastine,,,,Hodgkins lymphoma,,,,, -22913920,3383,,causes,,Vinblastine,,,,neoplasm,,,,, -14498052,3384,,affects,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, -12889760,3385,,affects,,Vinblastine,,,,renal cell carcinoma,,,,, -11723511,3386,,affects,,Vinblastine,,,,neoplasm,,,,, -19032862,3387,,disrupts,,Vinblastine,,,,neoplasm,,,,, -26195658,3388,,related to,,Desacetylvinblastine amide,,,,lymphoma,,,,, -26116904,3389,,related to,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, -25980030,3390,,related to,,Desacetylvinblastine amide,,,,small cell lung carcinoma,,,,, -26313629,3391,,affects,,Desacetylvinblastine amide,,,,neoplasm,,,,, -26201212,3392,,affects,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, -26302410,3393,,prevents,,Desacetylvinblastine amide,,,,neoplasm,,,,, -25951740,3394,,causes,,Diazoxide,,,,hyperinsulinism,,,,, -17059197,3395,,causes,,Diazoxide,,,,hypoglycemia,,,,, -25817473,3396,,affects,,Diazoxide,,,,hypertensive disorder,,,,, -20202762,3397,,affects,,Diazoxide,,,,obesity disorder,,,,, -11393233,3398,,affects,,Diazoxide,,,,hyperinsulinism,,,,, -8184004,3399,,affects,,Diazoxide,,,,hypoglycemia,,,,, -9572369,3400,,disrupts,,Diazoxide,,,,hyperinsulinism,,,,, -26286810,3401,,prevents,,Diazoxide,,,,hypoglycemia,,,,, -22404640,3402,,prevents,,Diazoxide,,,,hypertensive disorder,,,,, -19200973,3403,,prevents,,Diazoxide,,,,obesity disorder,,,,, -16737667,3404,,predisposes,,Diazoxide,,,,hypoglycemia,,,,, -14267417,3405,,affects,,Pantoprazole,,,,gastroesophageal reflux disease,,,,, -12160514,3406,,prevents,,Pantoprazole,,,,active peptic ulcer disease,,,,, -8423273,3407,,prevents,,Pantoprazole,,,,peptic ulcer disease,,,,, -7509578,3408,,prevents,,Pantoprazole,,,,ulcer disease,,,,, -21088628,3409,,predisposes,,Pantoprazole,,,,active peptic ulcer disease,,,,, -20047688,3410,,causes,,Lansoprazole,,,,gastric ulcer,,,,, -26544602,3411,,affects,,Lansoprazole,,,,peptic ulcer disease,,,,, -11547923,3412,,affects,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -10008124,3413,,affects,,Lansoprazole,,,,peptic esophagitis,,,,, -7314434,3414,,affects,,Lansoprazole,,,,Helicobacter pylori infectious disease,,,,, -9466998,3415,,disrupts,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -20033093,3416,,prevents,,Lansoprazole,,,,peptic ulcer disease,,,,, -15339719,3417,,prevents,,Lansoprazole,,,,duodenal ulcer,,,,, -9335785,3418,,prevents,,Lansoprazole,,,,gastric ulcer,,,,, -8183428,3419,,prevents,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -27664803,3420,,exacerbates,,Lansoprazole,,,,gastritis,,,,, -10008126,3421,,predisposes,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -10345128,3422,,subclass of,,Omeprazole,,,,Omeprazole sulfone,,,,, -8512321,3423,,subclass of,,Omeprazole,,,,Hydroxyomeprazole,,,,, -27115212,3424,,related to,,Omeprazole,,,,Omeprazole sulfone,,,,, -12365583,3425,,related to,,Omeprazole,,,,gastric ulcer,,,,, -7744216,3426,,related to,,Omeprazole,,,,Hydroxyomeprazole,,,,, -26722672,3427,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, -9932953,3428,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, -22198908,3429,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, -13085286,3430,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, -27703677,3431,,causes,,Omeprazole,,,,anemia,,,,, -27298440,3432,,causes,,Omeprazole,,,,Hemorrhage,,,,, -24514538,3433,,causes,,Omeprazole,,,,peptic ulcer disease,,,,, -19641302,3434,,causes,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -15956000,3435,,causes,,Omeprazole,,,,esophagitis,,,,, -12187782,3436,,causes,,Omeprazole,,,,ulcer disease,,,,, -11135889,3437,,causes,,Omeprazole,,,,injury,,,,, -10813876,3438,,causes,,Omeprazole,,,,Cough,,,,, -8871402,3439,,causes,,Omeprazole,,,,gastric ulcer,,,,, -7272148,3440,,causes,,Omeprazole,,,,duodenal ulcer,,,,, -27758339,3441,,affects,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, -27758338,3442,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, -27758337,3443,,affects,,Omeprazole,,,,peptic esophagitis,,,,, -27733079,3444,,affects,,Omeprazole,,,,peptic esophagitis,,,,, -27346919,3445,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, -22440533,3446,,affects,,Omeprazole,,,,anemia,,,,, -18634760,3447,,affects,,Omeprazole,,,,Pain,,,,, -17967745,3448,,affects,,Omeprazole,,,,injury,,,,, -12114858,3449,,affects,,Omeprazole,,,,ulcer disease,,,,, -11576921,3450,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, -10321262,3451,,affects,,Omeprazole,,,,duodenal ulcer,,,,, -9976497,3452,,affects,,Omeprazole,,,,gastric ulcer,,,,, -8694897,3453,,affects,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, -8349380,3454,,affects,,Omeprazole,,,,Hemorrhage,,,,, -8349375,3455,,affects,,Omeprazole,,,,Hemorrhage,,,,, -7653505,3456,,affects,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -7572363,3457,,affects,,Omeprazole,,,,ulcer disease,,,,, -14345083,3458,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, -26726289,3459,,disrupts,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -26000029,3460,,disrupts,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, -20129793,3461,,disrupts,,Omeprazole,,,,Barrett esophagus,,,,, -19299462,3462,,disrupts,,Omeprazole,,,,active peptic ulcer disease,,,,, -15524012,3463,,disrupts,,Omeprazole,,,,peptic ulcer disease,,,,, -13078646,3464,,disrupts,,Omeprazole,,,,ulcer disease,,,,, -10891179,3465,,disrupts,,Omeprazole,,,,gastric ulcer,,,,, -10776897,3466,,disrupts,,Omeprazole,,,,duodenal ulcer,,,,, -8884340,3467,,disrupts,,Omeprazole,,,,esophagitis,,,,, -27690262,3468,,prevents,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, -27025148,3469,,prevents,,Omeprazole,,,,Cough,,,,, -26715213,3470,,prevents,,Omeprazole,,,,Pain,,,,, -16929638,3471,,prevents,,Omeprazole,,,,esophagitis,,,,, -15601042,3472,,prevents,,Omeprazole,,,,active peptic ulcer disease,,,,, -9292674,3473,,prevents,,Omeprazole,,,,peptic ulcer disease,,,,, -8884338,3474,,prevents,,Omeprazole,,,,peptic esophagitis,,,,, -8341772,3475,,prevents,,Omeprazole,,,,duodenal ulcer,,,,, -8169375,3476,,prevents,,Omeprazole,,,,injury,,,,, -7646984,3477,,prevents,,Omeprazole,,,,gastric ulcer,,,,, -7653510,3478,,prevents,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -7332307,3479,,prevents,,Omeprazole,,,,ulcer disease,,,,, -24752030,3480,,predisposes,,Omeprazole,,,,type 2 diabetes mellitus,,,,, -21309680,3481,,predisposes,,Omeprazole,,,,melanoma,,,,, -20838741,3482,,predisposes,,Omeprazole,,,,Barrett esophagus,,,,, -12649375,3483,,affects,,Rabeprazole,,,,infectious disease,,,,, -11547924,3484,,affects,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, -15461842,3485,,disrupts,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, -16244495,3486,,prevents,,Rabeprazole,,,,peptic ulcer disease,,,,, -15354267,3487,,prevents,,Rabeprazole,,,,active peptic ulcer disease,,,,, -8397732,3488,,prevents,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, -23526790,3489,,causes,,Esomeprazole,,,,active peptic ulcer disease,,,,, -20333475,3490,,causes,,Esomeprazole,,,,preeclampsia,,,,, -15271081,3491,,causes,,Esomeprazole,,,,gastric ulcer,,,,, -22638872,3492,,affects,,Esomeprazole,,,,neoplasm,,,,, -20180848,3493,,affects,,Esomeprazole,,,,preeclampsia,,,,, -19360632,3494,,affects,,Esomeprazole,,,,ulcer disease,,,,, -18357402,3495,,affects,,Esomeprazole,,,,dyspepsia,,,,, -14247859,3496,,affects,,Esomeprazole,,,,gastric ulcer,,,,, -12902689,3497,,affects,,Esomeprazole,,,,Hemorrhage,,,,, -12902688,3498,,affects,,Esomeprazole,,,,Hemorrhage,,,,, -12527967,3499,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -12015567,3500,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -10805094,3501,,disrupts,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -15938697,3502,,prevents,,Esomeprazole,,,,gastric ulcer,,,,, -14015294,3503,,prevents,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -13576722,3504,,prevents,,Esomeprazole,,,,peptic ulcer disease,,,,, -12321750,3505,,prevents,,Esomeprazole,,,,ulcer disease,,,,, -10396538,3506,,related to,,Roflumilast,,,,asthma,,,,, -21017284,3507,,causes,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, -21116198,3508,,affects,,Roflumilast,,,,obesity disorder,,,,, -12290110,3509,,affects,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, -12290109,3510,,affects,,Roflumilast,,,,asthma,,,,, -22432515,3511,,disrupts,,Roflumilast,,,,schizophrenia,,,,, -24502817,3512,,prevents,,Roflumilast,,,,obesity disorder,,,,, -17763098,3513,,prevents,,Roflumilast,,,,diabetic kidney disease,,,,, -15955656,3514,,prevents,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, -8310806,3515,,causes,,Meperidine,,,,Pain,,,,, -26434893,3516,,affects,,Meperidine,,,,Pain,,,,, -18658715,3517,,affects,,Meperidine,,,,Pain,,,,, -8345324,3518,,prevents,,Meperidine,,,,Pain,,,,, -21672389,3519,,affects,,Ketobemidone,,,,Pain,,,,, -11850764,3520,,related to,,Travoprost,,,,ocular hypertension,,,,, -12116829,3521,,physically interacts with,,Travoprost,,,,prostanoid FP receptor,,,,, -18294152,3522,,affects,,Travoprost,,,,ocular hypertension,,,,, -18294151,3523,,affects,,Travoprost,,,,glaucoma,,,,, -10166996,3524,,prevents,,Travoprost,,,,ocular hypertension,,,,, -10166995,3525,,prevents,,Travoprost,,,,open-angle glaucoma,,,,, -17904574,3526,,related to,,Tafluprost,,,,glaucoma,,,,, -15304153,3527,,related to,,Tafluprost,,,,ocular hypertension,,,,, -15304152,3528,,related to,,Tafluprost,,,,open-angle glaucoma,,,,, -14941475,3529,,physically interacts with,,Tafluprost,,,,prostanoid FP receptor,,,,, -14941474,3530,,disrupts,,Tafluprost,,,,ocular hypertension,,,,, -14941473,3531,,disrupts,,Tafluprost,,,,open-angle glaucoma,,,,, -14231277,3532,,affects,,Ramelteon,,,,insomnia,,,,, -21718213,3533,,prevents,,Ramelteon,,,,sleep-wake disorder,,,,, -22873470,3534,,related to,,Melatonin,,,,acute kidney failure,,,,, -22002909,3535,,related to,,Melatonin,,,,metabolic disease,,,,, -21777340,3536,,related to,,Melatonin,,,,Cognitive impairment,,,,, -18920431,3537,,related to,,Melatonin,,,,burn,,,,, -18846352,3538,,related to,,Melatonin,,,,skin disorder,,,,, -18613354,3539,,related to,,Melatonin,,,,Neonatal sepsis,,,,, -18189253,3540,,related to,,Melatonin,,,,necrotizing enterocolitis,,,,, -17471678,3541,,related to,,Melatonin,,,,"dermatitis, atopic",,,,, -17103445,3542,,related to,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, -16423098,3543,,related to,,Melatonin,,,,periodontitis,,,,, -16022569,3544,,related to,,Melatonin,,,,metabolic syndrome X,,,,, -15882605,3545,,related to,,Melatonin,,,,enuresis,,,,, -15709123,3546,,related to,,Melatonin,,,,fibromyalgia,,,,, -15665905,3547,,related to,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, -14933527,3548,,related to,,Melatonin,,,,autism spectrum disorder,,,,, -14875890,3549,,related to,,Melatonin,,,,pervasive developmental disorder,,,,, -14786958,3550,,related to,,Melatonin,,,,gastroesophageal reflux disease,,,,, -13857052,3551,,related to,,Melatonin,,,,ulcerative colitis,,,,, -13491215,3552,,related to,,Melatonin,,,,diabetes mellitus,,,,, -13407170,3553,,related to,,Melatonin,,,,periodontal disorder,,,,, -13365823,3554,,related to,,Melatonin,,,,tooth disorder,,,,, -12843346,3555,,related to,,Melatonin,,,,melanoma,,,,, -12132104,3556,,related to,,Melatonin,,,,irritable bowel syndrome,,,,, -11584899,3557,,related to,,Melatonin,,,,brain ischemia,,,,, -11533403,3558,,related to,,Melatonin,,,,hypertensive disorder,,,,, -11319171,3559,,related to,,Melatonin,,,,Pain,,,,, -11137637,3560,,related to,,Melatonin,,,,essential hypertension,,,,, -10685850,3561,,related to,,Melatonin,,,,major depressive disorder,,,,, -10528037,3562,,related to,,Melatonin,,,,multiple sclerosis,,,,, -10477010,3563,,related to,,Melatonin,,,,non-small cell lung carcinoma,,,,, -10371972,3564,,related to,,Melatonin,,,,delirium,,,,, -10204563,3565,,related to,,Melatonin,,,,depressive disorder,,,,, -9947492,3566,,related to,,Melatonin,,,,myocardial infarction,,,,, -9516882,3567,,related to,,Melatonin,,,,Parkinson disease,,,,, -9086006,3568,,related to,,Melatonin,,,,ischemia reperfusion injury,,,,, -9074687,3569,,related to,,Melatonin,,,,Sepsis,,,,, -8867365,3570,,related to,,Melatonin,,,,schizophrenia,,,,, -8780387,3571,,related to,,Melatonin,,,,insomnia,,,,, -8686098,3572,,related to,,Melatonin,,,,dementia,,,,, -8623112,3573,,related to,,Melatonin,,,,migraine disorder,,,,, -7795396,3574,,related to,,Melatonin,,,,injury,,,,, -7482169,3575,,related to,,Melatonin,,,,neoplasm,,,,, -7440685,3576,,related to,,Melatonin,,,,Fatigue,,,,, -7185935,3577,,related to,,Melatonin,,,,epilepsy,,,,, -7185921,3578,,related to,,Melatonin,,,,sleep-wake disorder,,,,, -26987553,3579,,causes,,Melatonin,,,,Fatigue,,,,, -24500836,3580,,causes,,Melatonin,,,,anxiety,,,,, -22662368,3581,,causes,,Melatonin,,,,dementia,,,,, -21258564,3582,,causes,,Melatonin,,,,multiple sclerosis,,,,, -19886996,3583,,causes,,Melatonin,,,,Cognitive impairment,,,,, -19573910,3584,,causes,,Melatonin,,,,periodontitis,,,,, -17837306,3585,,causes,,Melatonin,,,,metabolic disease,,,,, -17714427,3586,,causes,,Melatonin,,,,myocardial infarction,,,,, -16705153,3587,,causes,,Melatonin,,,,Sepsis,,,,, -15644359,3588,,causes,,Melatonin,,,,gastroesophageal reflux disease,,,,, -14831403,3589,,causes,,Melatonin,,,,periodontal disorder,,,,, -14171289,3590,,causes,,Melatonin,,,,Parkinson disease,,,,, -14078373,3591,,causes,,Melatonin,,,,hypertensive disorder,,,,, -13896033,3592,,causes,,Melatonin,,,,breast neoplasm,,,,, -13361926,3593,,causes,,Melatonin,,,,ischemia reperfusion injury,,,,, -13039360,3594,,causes,,Melatonin,,,,epilepsy,,,,, -12762592,3595,,causes,,Melatonin,,,,enuresis,,,,, -12275569,3596,,causes,,Melatonin,,,,diabetes mellitus,,,,, -12071557,3597,,causes,,Melatonin,,,,insomnia,,,,, -10432083,3598,,causes,,Melatonin,,,,migraine disorder,,,,, -10432067,3599,,causes,,Melatonin,,,,schizophrenia,,,,, -9114525,3600,,causes,,Melatonin,,,,neoplasm,,,,, -8785660,3601,,causes,,Melatonin,,,,depressive disorder,,,,, -8291971,3602,,causes,,Melatonin,,,,injury,,,,, -25620630,3603,,affects,,Melatonin,,,,Fatigue,,,,, -25259613,3604,,affects,,Melatonin,,,,atrial fibrillation,,,,, -24144792,3605,,affects,,Melatonin,,,,myocardial infarction,,,,, -24094187,3606,,affects,,Melatonin,,,,major depressive disorder,,,,, -23101890,3607,,affects,,Melatonin,,,,periodontitis,,,,, -22037016,3608,,affects,,Melatonin,,,,diabetes mellitus,,,,, -21523229,3609,,affects,,Melatonin,,,,anxiety,,,,, -21046382,3610,,affects,,Melatonin,,,,non-small cell lung carcinoma,,,,, -20888328,3611,,affects,,Melatonin,,,,autism spectrum disorder,,,,, -18858036,3612,,affects,,Melatonin,,,,Cognitive impairment,,,,, -18703578,3613,,affects,,Melatonin,,,,Marchiafava-Bignami disease,,,,, -18605461,3614,,affects,,Melatonin,,,,Neonatal sepsis,,,,, -18605459,3615,,affects,,Melatonin,,,,Neonatal sepsis,,,,, -18111864,3616,,affects,,Melatonin,,,,Hemorrhage,,,,, -17774103,3617,,affects,,Melatonin,,,,fibromyalgia,,,,, -17471677,3618,,affects,,Melatonin,,,,"dermatitis, atopic",,,,, -17402992,3619,,affects,,Melatonin,,,,Fatigue,,,,, -17199486,3620,,affects,,Melatonin,,,,Sepsis,,,,, -17103446,3621,,affects,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, -17112614,3622,,affects,,Melatonin,,,,ulcerative colitis,,,,, -16898660,3623,,affects,,Melatonin,,,,Cognitive impairment,,,,, -16300651,3624,,affects,,Melatonin,,,,depressive disorder,,,,, -16293202,3625,,affects,,Melatonin,,,,Hemorrhage,,,,, -16189615,3626,,affects,,Melatonin,,,,Cognitive impairment,,,,, -15390003,3627,,affects,,Melatonin,,,,delirium,,,,, -14400565,3628,,affects,,Melatonin,,,,burn,,,,, -14333232,3629,,affects,,Melatonin,,,,schizophrenia,,,,, -13430046,3630,,affects,,Melatonin,,,,epilepsy,,,,, -13158859,3631,,affects,,Melatonin,,,,tooth disorder,,,,, -12620684,3632,,affects,,Melatonin,,,,melanoma,,,,, -12473519,3633,,affects,,Melatonin,,,,Parkinson disease,,,,, -11739216,3634,,affects,,Melatonin,,,,sleep-wake disorder,,,,, -11451669,3635,,affects,,Melatonin,,,,depressive disorder,,,,, -10979770,3636,,affects,,Melatonin,,,,insomnia,,,,, -10516034,3637,,affects,,Melatonin,,,,Pain,,,,, -10432086,3638,,affects,,Melatonin,,,,multiple sclerosis,,,,, -10047665,3639,,affects,,Melatonin,,,,hypertensive disorder,,,,, -9535418,3640,,affects,,Melatonin,,,,injury,,,,, -9364224,3641,,affects,,Melatonin,,,,Pain,,,,, -9244581,3642,,affects,,Melatonin,,,,migraine disorder,,,,, -9153135,3643,,affects,,Melatonin,,,,diabetes mellitus,,,,, -9143737,3644,,affects,,Melatonin,,,,epilepsy,,,,, -9114510,3645,,affects,,Melatonin,,,,ischemia reperfusion injury,,,,, -8993003,3646,,affects,,Melatonin,,,,neoplasm,,,,, -8720758,3647,,affects,,Melatonin,,,,breast neoplasm,,,,, -8108047,3648,,affects,,Melatonin,,,,depressive disorder,,,,, -7564928,3649,,affects,,Melatonin,,,,neoplasm,,,,, -7382212,3650,,affects,,Melatonin,,,,brain ischemia,,,,, -26765396,3651,,produces,,Melatonin,,,,epilepsy,,,,, -22867260,3652,,produces,,Melatonin,,,,diabetes mellitus,,,,, -18240585,3653,,produces,,Melatonin,,,,ulcerative colitis,,,,, -17207380,3654,,produces,,Melatonin,,,,autism spectrum disorder,,,,, -17051558,3655,,produces,,Melatonin,,,,depressive disorder,,,,, -16192357,3656,,produces,,Melatonin,,,,sleep-wake disorder,,,,, -13817260,3657,,produces,,Melatonin,,,,Parkinson disease,,,,, -11388402,3658,,produces,,Melatonin,,,,neoplasm,,,,, -9153153,3659,,produces,,Melatonin,,,,hypertensive disorder,,,,, -8191029,3660,,produces,,Melatonin,,,,breast neoplasm,,,,, -24623673,3661,,disrupts,,Melatonin,,,,atrial fibrillation,,,,, -24220852,3662,,disrupts,,Melatonin,,,,metabolic disease,,,,, -22817547,3663,,disrupts,,Melatonin,,,,anxiety,,,,, -20966258,3664,,disrupts,,Melatonin,,,,Cognitive impairment,,,,, -20623050,3665,,disrupts,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, -19958338,3666,,disrupts,,Melatonin,,,,multiple sclerosis,,,,, -18007482,3667,,disrupts,,Melatonin,,,,Sepsis,,,,, -18002672,3668,,disrupts,,Melatonin,,,,Pain,,,,, -16753621,3669,,disrupts,,Melatonin,,,,sleep-wake disorder,,,,, -14914180,3670,,disrupts,,Melatonin,,,,melanoma,,,,, -14617999,3671,,disrupts,,Melatonin,,,,"dermatitis, atopic",,,,, -13855513,3672,,disrupts,,Melatonin,,,,Hemorrhage,,,,, -10721769,3673,,disrupts,,Melatonin,,,,depressive disorder,,,,, -10333555,3674,,disrupts,,Melatonin,,,,injury,,,,, -10294227,3675,,disrupts,,Melatonin,,,,breast neoplasm,,,,, -10070181,3676,,disrupts,,Melatonin,,,,brain ischemia,,,,, -10008170,3677,,disrupts,,Melatonin,,,,Marchiafava-Bignami disease,,,,, -8932328,3678,,disrupts,,Melatonin,,,,epilepsy,,,,, -7916082,3679,,disrupts,,Melatonin,,,,ischemia reperfusion injury,,,,, -7545973,3680,,disrupts,,Melatonin,,,,neoplasm,,,,, -24902716,3681,,prevents,,Melatonin,,,,stomatitis,,,,, -24687342,3682,,prevents,,Melatonin,,,,essential hypertension,,,,, -24623674,3683,,prevents,,Melatonin,,,,atrial fibrillation,,,,, -24368351,3684,,prevents,,Melatonin,,,,acute kidney failure,,,,, -23824121,3685,,prevents,,Melatonin,,,,dementia,,,,, -23122960,3686,,prevents,,Melatonin,,,,Cognitive impairment,,,,, -22817548,3687,,prevents,,Melatonin,,,,anxiety,,,,, -21718214,3688,,prevents,,Melatonin,,,,sleep-wake disorder,,,,, -20260777,3689,,prevents,,Melatonin,,,,Pain,,,,, -19640170,3690,,prevents,,Melatonin,,,,aortic aneurysm,,,,, -18396849,3691,,prevents,,Melatonin,,,,Sepsis,,,,, -18141997,3692,,prevents,,Melatonin,,,,metabolic disease,,,,, -16995162,3693,,prevents,,Melatonin,,,,metabolic syndrome X,,,,, -16549748,3694,,prevents,,Melatonin,,,,burn,,,,, -16245777,3695,,prevents,,Melatonin,,,,schizophrenia,,,,, -16232642,3696,,prevents,,Melatonin,,,,Marchiafava-Bignami disease,,,,, -15150085,3697,,prevents,,Melatonin,,,,depressive disorder,,,,, -14373042,3698,,prevents,,Melatonin,,,,Parkinson disease,,,,, -11616466,3699,,prevents,,Melatonin,,,,autism spectrum disorder,,,,, -11366467,3700,,prevents,,Melatonin,,,,migraine disorder,,,,, -11108260,3701,,prevents,,Melatonin,,,,hypertensive disorder,,,,, -11061121,3702,,prevents,,Melatonin,,,,insomnia,,,,, -10234923,3703,,prevents,,Melatonin,,,,breast neoplasm,,,,, -10127047,3704,,prevents,,Melatonin,,,,myocardial infarction,,,,, -9561452,3705,,prevents,,Melatonin,,,,diabetes mellitus,,,,, -9346845,3706,,prevents,,Melatonin,,,,delirium,,,,, -9336280,3707,,prevents,,Melatonin,,,,brain ischemia,,,,, -8678642,3708,,prevents,,Melatonin,,,,epilepsy,,,,, -8166782,3709,,prevents,,Melatonin,,,,ischemia reperfusion injury,,,,, -7622774,3710,,prevents,,Melatonin,,,,injury,,,,, -7545974,3711,,prevents,,Melatonin,,,,neoplasm,,,,, -19276524,3712,,exacerbates,,Melatonin,,,,diabetes mellitus,,,,, -7980097,3713,,exacerbates,,Melatonin,,,,brain ischemia,,,,, -27283551,3714,,predisposes,,Melatonin,,,,hypertensive disorder,,,,, -23266236,3715,,predisposes,,Melatonin,,,,epilepsy,,,,, -21026194,3716,,predisposes,,Melatonin,,,,migraine disorder,,,,, -20835242,3717,,predisposes,,Melatonin,,,,metabolic syndrome X,,,,, -20419573,3718,,predisposes,,Melatonin,,,,major depressive disorder,,,,, -19382519,3719,,predisposes,,Melatonin,,,,periodontal disorder,,,,, -18749948,3720,,predisposes,,Melatonin,,,,autism spectrum disorder,,,,, -18605458,3721,,predisposes,,Melatonin,,,,Neonatal sepsis,,,,, -18359560,3722,,predisposes,,Melatonin,,,,depressive disorder,,,,, -16852096,3723,,predisposes,,Melatonin,,,,diabetes mellitus,,,,, -15094135,3724,,predisposes,,Melatonin,,,,injury,,,,, -14875892,3725,,predisposes,,Melatonin,,,,pervasive developmental disorder,,,,, -11794031,3726,,predisposes,,Melatonin,,,,neoplasm,,,,, -11643546,3727,,predisposes,,Melatonin,,,,dementia,,,,, -10915746,3728,,predisposes,,Melatonin,,,,sleep-wake disorder,,,,, -10114913,3729,,predisposes,,Melatonin,,,,myocardial infarction,,,,, -12950718,3730,,related to,,RETEPLASE,,,,thrombotic disease,,,,, -7082056,3731,,related to,,RETEPLASE,,,,stroke disorder,,,,, -12026281,3732,,related to,,UROKINASE,,,,stroke disorder,,,,, -11808316,3733,,related to,,UROKINASE,,,,empyema,,,,, -9909017,3734,,related to,,UROKINASE,,,,pleural empyema,,,,, -9695495,3735,,related to,,UROKINASE,,,,thrombotic disease,,,,, -7757067,3736,,related to,,UROKINASE,,,,pulmonary embolism,,,,, -20949144,3737,,causes,,UROKINASE,,,,thrombotic disease,,,,, -7392657,3738,,causes,,UROKINASE,,,,pulmonary embolism,,,,, -26135964,3739,,affects,,UROKINASE,,,,pulmonary embolism,,,,, -25781305,3740,,affects,,UROKINASE,,,,thrombotic disease,,,,, -26885635,3741,,disrupts,,UROKINASE,,,,thrombotic disease,,,,, -11607211,3742,,prevents,,UROKINASE,,,,thrombotic disease,,,,, -8505599,3743,,prevents,,UROKINASE,,,,pulmonary embolism,,,,, -26334889,3744,,predisposes,,UROKINASE,,,,pulmonary embolism,,,,, -13797160,3745,,predisposes,,UROKINASE,,,,thrombotic disease,,,,, -13590349,3746,,causes,,Buspirone,,,,depressive disorder,,,,, -7712722,3747,,affects,,Buspirone,,,,depressive disorder,,,,, -7425584,3748,,affects,,Buspirone,,,,physiological sexual disorder,,,,, -19950288,3749,,disrupts,,Buspirone,,,,schizophrenia,,,,, -10992881,3750,,disrupts,,Buspirone,,,,anxiety,,,,, -19904227,3751,,related to,,Iodine,,,,thyroid tumor,,,,, -10048388,3752,,related to,,Iodine,,,,breast neoplasm,,,,, -10651106,3753,,causes,,Iodine,,,,thyroid tumor,,,,, -10745802,3754,,affects,,Iodine,,,,thyroid tumor,,,,, -24773674,3755,,prevents,,Iodine,,,,thyroid tumor,,,,, -27167996,3756,,predisposes,,Iodine,,,,thyroid tumor,,,,, -7362584,3757,,subclass of,,Acetaminophen,,,,Acetaminophen sulfate,,,,, -7362582,3758,,subclass of,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -26133523,3759,,related to,,Acetaminophen,,,,neoplasm,,,,, -25084939,3760,,related to,,Acetaminophen,,,,Acetimidoquinone,,,,, -24055705,3761,,related to,,Acetaminophen,,,,osteoarthritis,,,,, -20371329,3762,,related to,,Acetaminophen,,,,digestive system disorder,,,,, -19637295,3763,,related to,,Acetaminophen,,,,Renal Colic,,,,, -16009572,3764,,related to,,Acetaminophen,,,,rheumatoid arthritis,,,,, -12233599,3765,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -12541409,3766,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -15777318,3767,,coexists with,,Acetaminophen,,,,Acetimidoquinone,,,,, -18513016,3768,,derives from,,Acetaminophen,,,,Acetimidoquinone,,,,, -16596646,3769,,derives from,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -7891577,3770,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, -11100770,3771,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, -8441876,3772,,physically interacts with,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -25685005,3773,,causes,,Acetaminophen,,,,neoplasm,,,,, -24327037,3774,,causes,,Acetaminophen,,,,anxiety,,,,, -23482103,3775,,causes,,Acetaminophen,,,,nervous system disorder,,,,, -21920646,3776,,causes,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, -21160030,3777,,causes,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, -19409287,3778,,causes,,Acetaminophen,,,,myopia,,,,, -17485084,3779,,causes,,Acetaminophen,,,,obesity disorder,,,,, -17093716,3780,,causes,,Acetaminophen,,,,kidney disorder,,,,, -16903597,3781,,causes,,Acetaminophen,,,,hypertensive disorder,,,,, -16867510,3782,,causes,,Acetaminophen,,,,delirium,,,,, -16756158,3783,,causes,,Acetaminophen,,,,osteoarthritis,,,,, -16155885,3784,,causes,,Acetaminophen,,,,Hemorrhage,,,,, -15922778,3785,,causes,,Acetaminophen,,,,Pruritus,,,,, -14972793,3786,,causes,,Acetaminophen,,,,brain injury,,,,, -12302511,3787,,causes,,Acetaminophen,,,,Headache,,,,, -9507087,3788,,causes,,Acetaminophen,,,,Vomiting,,,,, -8697178,3789,,causes,,Acetaminophen,,,,Pain,,,,, -8697177,3790,,causes,,Acetaminophen,,,,Fever,,,,, -7330301,3791,,causes,,Acetaminophen,,,,injury,,,,, -24793249,3792,,affects,,Acetaminophen,,,,hypertensive disorder,,,,, -23912807,3793,,affects,,Acetaminophen,,,,Vomiting,,,,, -23912806,3794,,affects,,Acetaminophen,,,,Nausea,,,,, -23442508,3795,,affects,,Acetaminophen,,,,pharyngitis,,,,, -23226380,3796,,affects,,Acetaminophen,,,,anxiety,,,,, -22849168,3797,,affects,,Acetaminophen,,,,neoplasm,,,,, -22389406,3798,,affects,,Acetaminophen,,,,Low back pain,,,,, -22267005,3799,,affects,,Acetaminophen,,,,Acute Pain,,,,, -21609859,3800,,affects,,Acetaminophen,,,,migraine disorder,,,,, -21375424,3801,,affects,,Acetaminophen,,,,preeclampsia,,,,, -21166764,3802,,affects,,Acetaminophen,,,,Parkinson disease,,,,, -20477729,3803,,affects,,Acetaminophen,,,,Hemorrhage,,,,, -20447454,3804,,affects,,Acetaminophen,,,,rheumatoid arthritis,,,,, -19937801,3805,,affects,,Acetaminophen,,,,Pain,,,,, -19285056,3806,,affects,,Acetaminophen,,,,Renal Colic,,,,, -18899993,3807,,affects,,Acetaminophen,,,,Abdominal pain,,,,, -18709599,3808,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, -18394888,3809,,affects,,Acetaminophen,,,,Headache,,,,, -18298999,3810,,affects,,Acetaminophen,,,,patent ductus arteriosus,,,,, -16707575,3811,,affects,,Acetaminophen,,,,obesity disorder,,,,, -16662805,3812,,affects,,Acetaminophen,,,,Vomiting,,,,, -16662804,3813,,affects,,Acetaminophen,,,,Nausea,,,,, -15922777,3814,,affects,,Acetaminophen,,,,Pruritus,,,,, -15909356,3815,,affects,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, -12673406,3816,,affects,,Acetaminophen,,,,bone fracture,,,,, -12488756,3817,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -11625632,3818,,affects,,Acetaminophen,,,,Chronic pain,,,,, -11439823,3819,,affects,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, -11319146,3820,,affects,,Acetaminophen,,,,neuralgia,,,,, -11289717,3821,,affects,,Acetaminophen,,,,osteoarthritis,,,,, -11227783,3822,,affects,,Acetaminophen,,,,Fever,,,,, -11159989,3823,,affects,,Acetaminophen,,,,Hemorrhage,,,,, -10410536,3824,,affects,,Acetaminophen,,,,injury,,,,, -10195419,3825,,affects,,Acetaminophen,,,,Pain,,,,, -9259287,3826,,affects,,Acetaminophen,,,,Fever,,,,, -8642669,3827,,affects,,Acetaminophen,,,,Hemorrhage,,,,, -8097597,3828,,affects,,Acetaminophen,,,,injury,,,,, -25639149,3829,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -20782169,3830,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, -25481457,3831,,disrupts,,Acetaminophen,,,,patent ductus arteriosus,,,,, -25355292,3832,,disrupts,,Acetaminophen,,,,delirium,,,,, -19614622,3833,,disrupts,,Acetaminophen,,,,Headache,,,,, -16273113,3834,,disrupts,,Acetaminophen,,,,Fever,,,,, -12102031,3835,,disrupts,,Acetaminophen,,,,Pain,,,,, -7794905,3836,,disrupts,,Acetaminophen,,,,influenza,,,,, -7640332,3837,,disrupts,,Acetaminophen,,,,injury,,,,, -26559635,3838,,prevents,,Acetaminophen,,,,malaria,,,,, -22159381,3839,,prevents,,Acetaminophen,,,,Hemorrhage,,,,, -22123298,3840,,prevents,,Acetaminophen,,,,Fever,,,,, -20154151,3841,,prevents,,Acetaminophen,,,,neuralgia,,,,, -20107193,3842,,prevents,,Acetaminophen,,,,delirium,,,,, -19168014,3843,,prevents,,Acetaminophen,,,,obesity disorder,,,,, -19006111,3844,,prevents,,Acetaminophen,,,,patent ductus arteriosus,,,,, -18131378,3845,,prevents,,Acetaminophen,,,,Low back pain,,,,, -18033682,3846,,prevents,,Acetaminophen,,,,Vomiting,,,,, -16975983,3847,,prevents,,Acetaminophen,,,,neoplasm,,,,, -16828191,3848,,prevents,,Acetaminophen,,,,rheumatoid arthritis,,,,, -16784082,3849,,prevents,,Acetaminophen,,,,injury,,,,, -16782348,3850,,prevents,,Acetaminophen,,,,Nausea,,,,, -15909357,3851,,prevents,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, -15525446,3852,,prevents,,Acetaminophen,,,,Acute Pain,,,,, -15467414,3853,,prevents,,Acetaminophen,,,,influenza,,,,, -14660734,3854,,prevents,,Acetaminophen,,,,cardiac rhythm disease,,,,, -14372292,3855,,prevents,,Acetaminophen,,,,Headache,,,,, -13804263,3856,,prevents,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, -8695490,3857,,prevents,,Acetaminophen,,,,Pain,,,,, -25567880,3858,,predisposes,,Acetaminophen,,,,Sepsis,,,,, -24917204,3859,,predisposes,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, -22230555,3860,,predisposes,,Acetaminophen,,,,delirium,,,,, -21723139,3861,,predisposes,,Acetaminophen,,,,Hemorrhage,,,,, -20594449,3862,,predisposes,,Acetaminophen,,,,neoplasm,,,,, -19914508,3863,,predisposes,,Acetaminophen,,,,Pain,,,,, -16209480,3864,,predisposes,,Acetaminophen,,,,kidney disorder,,,,, -13597848,3865,,predisposes,,Acetaminophen,,,,injury,,,,, -13536066,3866,,predisposes,,Acetaminophen,,,,non-small cell lung carcinoma,,,,, -12673403,3867,,predisposes,,Acetaminophen,,,,bone fracture,,,,, -12109634,3868,,predisposes,,Acetaminophen,,,,Parkinson disease,,,,, -11873681,3869,,predisposes,,Acetaminophen,,,,non-Hodgkin lymphoma,,,,, -9834508,3870,,predisposes,,Acetaminophen,,,,hypertensive disorder,,,,, -8862839,3871,,predisposes,,Acetaminophen,,,,streptococcal infection,,,,, -10289439,3872,,related to,,Chlorthalidone,,,,hypertensive disorder,,,,, -10185607,3873,,related to,,Chlorthalidone,,,,coronary artery disorder,,,,, -10185606,3874,,related to,,Chlorthalidone,,,,myocardial infarction,,,,, -7839079,3875,,related to,,Chlorthalidone,,,,essential hypertension,,,,, -21616164,3876,,affects,,Chlorthalidone,,,,myocardial infarction,,,,, -21616163,3877,,affects,,Chlorthalidone,,,,coronary artery disorder,,,,, -16399514,3878,,affects,,Chlorthalidone,,,,essential hypertension,,,,, -16281975,3879,,affects,,Chlorthalidone,,,,hypertensive disorder,,,,, -11587035,3880,,affects,,Chlorthalidone,,,,diabetes mellitus,,,,, -11095498,3881,,prevents,,Chlorthalidone,,,,myocardial infarction,,,,, -11095497,3882,,prevents,,Chlorthalidone,,,,coronary artery disorder,,,,, -8853238,3883,,prevents,,Chlorthalidone,,,,myocardial ischemia,,,,, -8036244,3884,,prevents,,Chlorthalidone,,,,hypertensive disorder,,,,, -11078982,3885,,predisposes,,Chlorthalidone,,,,coronary artery disorder,,,,, -19123757,3886,,causes,,Propacetamol,,,,Pain,,,,, -11402898,3887,,prevents,,Propacetamol,,,,Pain,,,,, -25540651,3888,,affects,,Isopropyl Alcohol,,,,Nausea,,,,, -18311094,3889,,affects,,Isopropyl Alcohol,,,,infectious disease,,,,, -10697335,3890,,affects,,Isopropyl Alcohol,,,,burn,,,,, -9427033,3891,,prevents,,Isopropyl Alcohol,,,,infectious disease,,,,, -21320482,3892,,related to,,Ethanol,,,,substance-related disorder,,,,, -15908919,3893,,related to,,Ethanol,,,,hypertensive disorder,,,,, -14538852,3894,,related to,,Ethanol,,,,atrial fibrillation,,,,, -13852361,3895,,related to,,Ethanol,,,,obesity disorder,,,,, -27116018,3896,,causes,,Ethanol,,,,neutropenia,,,,, -26520376,3897,,causes,,Ethanol,,,,essential hypertension,,,,, -17336935,3898,,causes,,Ethanol,,,,Tremor,,,,, -15073107,3899,,causes,,Ethanol,,,,alcohol-related disorders,,,,, -14779551,3900,,causes,,Ethanol,,,,burn,,,,, -12227250,3901,,causes,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, -11665347,3902,,causes,,Ethanol,,,,erectile dysfunction,,,,, -11096896,3903,,causes,,Ethanol,,,,type 2 diabetes mellitus,,,,, -10962858,3904,,causes,,Ethanol,,,,atrial fibrillation,,,,, -9159992,3905,,causes,,Ethanol,,,,obesity disorder,,,,, -8743651,3906,,causes,,Ethanol,,,,alcohol abuse,,,,, -8636726,3907,,causes,,Ethanol,,,,major depressive disorder,,,,, -8268450,3908,,causes,,Ethanol,,,,atopic eczema,,,,, -7771647,3909,,causes,,Ethanol,,,,hypertensive disorder,,,,, -7460012,3910,,causes,,Ethanol,,,,cirrhosis of liver,,,,, -27580478,3911,,affects,,Ethanol,,,,cirrhosis of liver,,,,, -27514790,3912,,affects,,Ethanol,,,,Thyroid nodule,,,,, -26762447,3913,,affects,,Ethanol,,,,neutropenia,,,,, -23912654,3914,,affects,,Ethanol,,,,atrial fibrillation,,,,, -23763968,3915,,affects,,Ethanol,,,,substance-related disorder,,,,, -19533165,3916,,affects,,Ethanol,,,,hypertensive disorder,,,,, -19155713,3917,,affects,,Ethanol,,,,cannabis dependence,,,,, -16819917,3918,,affects,,Ethanol,,,,Chronic pain,,,,, -15671844,3919,,affects,,Ethanol,,,,obesity disorder,,,,, -14737169,3920,,affects,,Ethanol,,,,Chronic pain,,,,, -14527564,3921,,affects,,Ethanol,,,,benign prostatic hyperplasia,,,,, -13226372,3922,,affects,,Ethanol,,,,atrial fibrillation,,,,, -12698965,3923,,affects,,Ethanol,,,,major depressive disorder,,,,, -12166837,3924,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, -10697334,3925,,affects,,Ethanol,,,,burn,,,,, -9822489,3926,,affects,,Ethanol,,,,Tremor,,,,, -9174558,3927,,affects,,Ethanol,,,,Tremor,,,,, -9116052,3928,,affects,,Ethanol,,,,major depressive disorder,,,,, -8931619,3929,,affects,,Ethanol,,,,hypertensive disorder,,,,, -8730041,3930,,affects,,Ethanol,,,,burn,,,,, -8616967,3931,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, -8569555,3932,,affects,,Ethanol,,,,alcohol abuse,,,,, -8363507,3933,,affects,,Ethanol,,,,obesity disorder,,,,, -7210977,3934,,affects,,Ethanol,,,,alcohol abuse,,,,, -25366419,3935,,disrupts,,Ethanol,,,,ventricular tachycardia,,,,, -24747388,3936,,disrupts,,Ethanol,,,,obesity disorder,,,,, -22793590,3937,,disrupts,,Ethanol,,,,Infection,,,,, -20664067,3938,,disrupts,,Ethanol,,,,Chronic pain,,,,, -19084276,3939,,disrupts,,Ethanol,,,,hypertensive disorder,,,,, -15586620,3940,,disrupts,,Ethanol,,,,Tremor,,,,, -15580442,3941,,disrupts,,Ethanol,,,,atrial fibrillation,,,,, -12535146,3942,,disrupts,,Ethanol,,,,type 2 diabetes mellitus,,,,, -9920913,3943,,disrupts,,Ethanol,,,,constipation disorder,,,,, -27717904,3944,,prevents,,Ethanol,,,,cirrhosis of liver,,,,, -22976273,3945,,prevents,,Ethanol,,,,Infection,,,,, -21338360,3946,,prevents,,Ethanol,,,,atrial fibrillation,,,,, -20664068,3947,,prevents,,Ethanol,,,,Chronic pain,,,,, -14465260,3948,,prevents,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, -13158318,3949,,prevents,,Ethanol,,,,erectile dysfunction,,,,, -12078103,3950,,prevents,,Ethanol,,,,alcohol abuse,,,,, -11890775,3951,,prevents,,Ethanol,,,,type 2 diabetes mellitus,,,,, -11547578,3952,,prevents,,Ethanol,,,,Tremor,,,,, -10032139,3953,,prevents,,Ethanol,,,,obesity disorder,,,,, -8207881,3954,,prevents,,Ethanol,,,,hypertensive disorder,,,,, -26228661,3955,,predisposes,,Ethanol,,,,essential hypertension,,,,, -23006394,3956,,predisposes,,Ethanol,,,,constipation disorder,,,,, -21458894,3957,,predisposes,,Ethanol,,,,burn,,,,, -21015200,3958,,predisposes,,Ethanol,,,,benign prostatic hyperplasia,,,,, -20014749,3959,,predisposes,,Ethanol,,,,neuroblastoma,,,,, -19550164,3960,,predisposes,,Ethanol,,,,endometriosis,,,,, -15239058,3961,,predisposes,,Ethanol,,,,cannabis dependence,,,,, -13742110,3962,,predisposes,,Ethanol,,,,cirrhosis of liver,,,,, -13158317,3963,,predisposes,,Ethanol,,,,erectile dysfunction,,,,, -11801709,3964,,predisposes,,Ethanol,,,,type 2 diabetes mellitus,,,,, -11652545,3965,,predisposes,,Ethanol,,,,obesity disorder,,,,, -11461204,3966,,predisposes,,Ethanol,,,,atrial fibrillation,,,,, -9864711,3967,,predisposes,,Ethanol,,,,major depressive disorder,,,,, -9226083,3968,,predisposes,,Ethanol,,,,alcohol abuse,,,,, -8895200,3969,,predisposes,,Ethanol,,,,hypertensive disorder,,,,, -22402878,3970,,related to,,Sodium Hypochlorite,,,,Infection,,,,, -22402879,3971,,prevents,,Sodium Hypochlorite,,,,Infection,,,,, -22325598,3972,,prevents,,Sodium Hypochlorite,,,,Pain,,,,, -23522159,3973,,related to,,Hydrogen Peroxide,,,,gingivitis,,,,, -10185817,3974,,related to,,Hydrogen Peroxide,,,,acne,,,,, -9091124,3975,,related to,,Hydrogen Peroxide,,,,injury,,,,, -21979927,3976,,causes,,Hydrogen Peroxide,,,,seborrheic keratosis,,,,, -7121153,3977,,causes,,Hydrogen Peroxide,,,,injury,,,,, -18988282,3978,,affects,,Hydrogen Peroxide,,,,severe acute respiratory syndrome,,,,, -15261236,3979,,affects,,Hydrogen Peroxide,,,,gingivitis,,,,, -9489971,3980,,affects,,Hydrogen Peroxide,,,,injury,,,,, -7188934,3981,,affects,,Hydrogen Peroxide,,,,injury,,,,, -20490056,3982,,disrupts,,Hydrogen Peroxide,,,,dental caries,,,,, -17081431,3983,,disrupts,,Hydrogen Peroxide,,,,injury,,,,, -8804977,3984,,disrupts,,Hydrogen Peroxide,,,,gingivitis,,,,, -21124110,3985,,prevents,,Hydrogen Peroxide,,,,acne,,,,, -11091070,3986,,prevents,,Hydrogen Peroxide,,,,gingivitis,,,,, -7482647,3987,,prevents,,Hydrogen Peroxide,,,,injury,,,,, -19925807,3988,,predisposes,,Hydrogen Peroxide,,,,dental caries,,,,, -10852631,3989,,predisposes,,Hydrogen Peroxide,,,,injury,,,,, -23181733,3990,,related to,,Vitamin K1,,,,Hemorrhage,,,,, -20221966,3991,,related to,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, -19764095,3992,,related to,,Vitamin K1,,,,osteoporosis,,,,, -17682094,3993,,related to,,Vitamin K1,,,,atrial fibrillation,,,,, -13777524,3994,,related to,,Vitamin K1,,,,cystic fibrosis,,,,, -11304774,3995,,affects,,Vitamin K1,,,,Hemorrhage,,,,, -24408540,3996,,prevents,,Vitamin K1,,,,Hemorrhage,,,,, -13476259,3997,,prevents,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, -10772424,3998,,predisposes,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, -9319754,3999,,predisposes,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, -24430542,4000,,causes,,Indapamide,,,,type 2 diabetes mellitus,,,,, -24430545,4001,,affects,,Indapamide,,,,type 2 diabetes mellitus,,,,, -10214767,4002,,affects,,Indapamide,,,,hypertensive disorder,,,,, -13327254,4003,,prevents,,Indapamide,,,,hypertensive disorder,,,,, -18173402,4004,,related to,,Perphenazine,,,,schizophrenia,,,,, -11307427,4005,,related to,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, -19924977,4006,,disrupts,,Perphenazine,,,,cocaine dependence,,,,, -19924976,4007,,disrupts,,Perphenazine,,,,schizophrenia,,,,, -15171439,4008,,prevents,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, -27208453,4009,,exacerbates,,Perphenazine,,,,dementia,,,,, -26847530,4010,,affects,,Fluphenazine,,,,psychotic disorder,,,,, -11127872,4011,,prevents,,Fluphenazine,,,,psychotic disorder,,,,, -10396371,4012,,disrupts,,Prochlorperazine,,,,Nausea,,,,, -11808182,4013,,prevents,,Prochlorperazine,,,,Postoperative Nausea and Vomiting,,,,, -10634177,4014,,prevents,,Prochlorperazine,,,,migraine disorder,,,,, -7427448,4015,,prevents,,Prochlorperazine,,,,Nausea,,,,, -11272109,4016,,related to,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, -26291786,4017,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, -26291786,4018,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, -16241796,4019,,physically interacts with,,ELOSULFASE ALFA,,,,Keratan,,,,, -16652816,4020,,causes,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, -13130107,4021,,affects,,ELOSULFASE ALFA,,,,Keratan,,,,, -21593588,4022,,related to,,Pegvaliase,,,,phenylketonuria,,,,, -23111774,4023,,related to,,Labetalol,,,,preeclampsia,,,,, -19865755,4024,,related to,,Labetalol,,,,hypertensive disorder,,,,, -19886747,4025,,causes,,Labetalol,,,,hypertensive disorder,,,,, -7968423,4026,,causes,,Labetalol,,,,hypotensive disorder,,,,, -26371124,4027,,affects,,Labetalol,,,,hypertensive disorder,,,,, -16245918,4028,,affects,,Labetalol,,,,stroke disorder,,,,, -15472186,4029,,affects,,Labetalol,,,,hypertensive disorder,,,,, -11424839,4030,,affects,,Labetalol,,,,hypotensive disorder,,,,, -24194004,4031,,prevents,,Labetalol,,,,preeclampsia,,,,, -16282554,4032,,prevents,,Labetalol,,,,hypertensive disorder,,,,, -16892434,4033,,predisposes,,Labetalol,,,,stroke disorder,,,,, -15232781,4034,,related to,,Carvedilol,,,,hypertensive disorder,,,,, -15407113,4035,,causes,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -14049404,4036,,causes,,Carvedilol,,,,epilepsy,,,,, -19046224,4037,,affects,,Carvedilol,,,,esophageal varices,,,,, -17542363,4038,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -11530189,4039,,affects,,Carvedilol,,,,essential hypertension,,,,, -11200172,4040,,affects,,Carvedilol,,,,atrial fibrillation,,,,, -10614289,4041,,affects,,Carvedilol,,,,Stable angina,,,,, -10614288,4042,,affects,,Carvedilol,,,,hypertensive disorder,,,,, -10402879,4043,,affects,,Carvedilol,,,,hypertensive disorder,,,,, -9269217,4044,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -9116913,4045,,affects,,Carvedilol,,,,cardiovascular disorder,,,,, -7256243,4046,,affects,,Carvedilol,,,,portal hypertension,,,,, -24587957,4047,,disrupts,,Carvedilol,,,,portal hypertension,,,,, -21108262,4048,,disrupts,,Carvedilol,,,,myocardial infarction,,,,, -13210472,4049,,disrupts,,Carvedilol,,,,atrial fibrillation,,,,, -23631897,4050,,prevents,,Carvedilol,,,,neoplasm,,,,, -23413400,4051,,prevents,,Carvedilol,,,,myocardial infarction,,,,, -20796578,4052,,prevents,,Carvedilol,,,,hypoglycemia,,,,, -17416516,4053,,prevents,,Carvedilol,,,,portal hypertension,,,,, -15996194,4054,,prevents,,Carvedilol,,,,hypertensive disorder,,,,, -15794060,4055,,prevents,,Carvedilol,,,,Abnormal left ventricular function,,,,, -15707001,4056,,prevents,,Carvedilol,,,,kidney disorder,,,,, -12564717,4057,,prevents,,Carvedilol,,,,atrial fibrillation,,,,, -8686828,4058,,prevents,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -23747042,4059,,predisposes,,Carvedilol,,,,type 2 diabetes mellitus,,,,, -22663350,4060,,predisposes,,Carvedilol,,,,atrial fibrillation,,,,, -21640789,4061,,predisposes,,Carvedilol,,,,hypoglycemia,,,,, -21331523,4062,,predisposes,,Carvedilol,,,,myocardial infarction,,,,, -20291576,4063,,related to,,Raloxifene,,,,schizophrenia,,,,, -13558027,4064,,related to,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -27583128,4065,,causes,,Raloxifene,,,,breast neoplasm,,,,, -20242808,4066,,affects,,Raloxifene,,,,psychotic disorder,,,,, -16098538,4067,,affects,,Raloxifene,,,,schizophrenia,,,,, -15267794,4068,,affects,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, -11233936,4069,,affects,,Raloxifene,,,,breast neoplasm,,,,, -10869334,4070,,affects,,Raloxifene,,,,osteoporosis,,,,, -9569313,4071,,affects,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -15267792,4072,,disrupts,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, -13369623,4073,,disrupts,,Raloxifene,,,,osteoporosis,,,,, -7874352,4074,,disrupts,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -16984197,4075,,prevents,,Raloxifene,,,,Alzheimer disease,,,,, -12036378,4076,,prevents,,Raloxifene,,,,breast neoplasm,,,,, -7813032,4077,,prevents,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -7578651,4078,,prevents,,Raloxifene,,,,osteoporosis,,,,, -7570810,4079,,prevents,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, -11746046,4080,,predisposes,,Raloxifene,,,,Alzheimer disease,,,,, -11350173,4081,,predisposes,,Raloxifene,,,,osteoporosis,,,,, -23481448,4082,,prevents,,Bazedoxifene acetate,,,,osteoporosis,,,,, -19905553,4083,,disrupts,,Ospemifene,,,,psychologic dyspareunia,,,,, -15516940,4084,,affects,,Sufentanil,,,,Pain,,,,, -20743116,4085,,prevents,,Sufentanil,,,,delirium,,,,, -8151024,4086,,prevents,,Sufentanil,,,,Pain,,,,, -12819365,4087,,related to,,Streptomycin,,,,Buruli ulcer disease,,,,, -11425591,4088,,related to,,Streptomycin,,,,osteomyelitis,,,,, -10417352,4089,,related to,,Streptomycin,,,,plague,,,,, -10748245,4090,,causes,,Streptomycin,,,,plague,,,,, -26655494,4091,,prevents,,Streptomycin,,,,mycobacterium avium complex disease,,,,, -14226518,4092,,related to,,Paromomycin,,,,cutaneous leishmaniasis,,,,, -12550860,4093,,related to,,Paromomycin,,,,visceral leishmaniasis,,,,, -24692385,4094,,affects,,Paromomycin,,,,leishmaniasis,,,,, -23700620,4095,,affects,,Paromomycin,,,,visceral leishmaniasis,,,,, -22567030,4096,,affects,,Paromomycin,,,,cutaneous leishmaniasis,,,,, -27729096,4097,,related to,,Kanamycin,,,,bacterial infectious disease,,,,, -10553348,4098,,related to,,Kanamycin,,,,tuberculosis,,,,, -10567002,4099,,affects,,Kanamycin,,,,tuberculosis,,,,, -25418796,4100,,related to,,Vancomycin,,,,ulcerative colitis,,,,, -24528866,4101,,related to,,Vancomycin,,,,bacterial infectious disease,,,,, -23989025,4102,,related to,,Vancomycin,,,,Inflammation,,,,, -22667296,4103,,related to,,Vancomycin,,,,arthropathy,,,,, -21740759,4104,,related to,,Vancomycin,,,,Infection,,,,, -20543239,4105,,related to,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, -20099844,4106,,related to,,Vancomycin,,,,cystic fibrosis,,,,, -18717834,4107,,related to,,Vancomycin,,,,eye infectious disorder,,,,, -18563763,4108,,related to,,Vancomycin,,,,staphylococcal pneumonia,,,,, -17578296,4109,,related to,,Vancomycin,,,,Peptidoglycan,,,,, -17578296,4110,,related to,,Vancomycin,,,,Peptidoglycan,,,,, -15843803,4111,,related to,,Vancomycin,,,,Diabetic Foot,,,,, -15502624,4112,,related to,,Vancomycin,,,,abscess,,,,, -15448370,4113,,related to,,Vancomycin,,,,obesity disorder,,,,, -15389679,4114,,related to,,Vancomycin,,,,osteomyelitis,,,,, -15008716,4115,,related to,,Vancomycin,,,,peritonitis,,,,, -14607992,4116,,related to,,Vancomycin,,,,pneumonia,,,,, -14564943,4117,,related to,,Vancomycin,,,,gram-positive bacterial infections,,,,, -11348824,4118,,related to,,Vancomycin,,,,kidney failure,,,,, -11195361,4119,,related to,,Vancomycin,,,,Neonatal sepsis,,,,, -10946982,4120,,related to,,Vancomycin,,,,respiratory tract infectious disorder,,,,, -10225522,4121,,related to,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, -9057886,4122,,related to,,Vancomycin,,,,nosocomial infection,,,,, -9057885,4123,,related to,,Vancomycin,,,,staphylococcal infection,,,,, -8859000,4124,,related to,,Vancomycin,,,,endocarditis,,,,, -8170422,4125,,related to,,Vancomycin,,,,Sepsis,,,,, -23445509,4126,,related to,,Vancomycin,,,,peritonitis,,,,, -22719539,4127,,related to,,Vancomycin,,,,Infection,,,,, -11098147,4128,,related to,,Vancomycin,,,,Inflammation,,,,, -14094746,4129,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, -14094746,4130,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, -7840667,4131,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, -7710804,4132,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, -26896148,4133,,causes,,Vancomycin,,,,endocarditis,,,,, -26320414,4134,,causes,,Vancomycin,,,,enterocolitis,,,,, -22849619,4135,,causes,,Vancomycin,,,,Infection,,,,, -22231760,4136,,causes,,Vancomycin,,,,Inflammation,,,,, -21632936,4137,,causes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, -18945219,4138,,causes,,Vancomycin,,,,peritonitis,,,,, -15481792,4139,,causes,,Vancomycin,,,,skin disorder,,,,, -12001625,4140,,causes,,Vancomycin,,,,kidney failure,,,,, -9570250,4141,,causes,,Vancomycin,,,,nosocomial infection,,,,, -23893373,4142,,affects,,Vancomycin,,,,Infection,,,,, -21581118,4143,,affects,,Vancomycin,,,,Infection,,,,, -21291384,4144,,affects,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, -20283933,4145,,affects,,Vancomycin,,,,enterocolitis,,,,, -19879029,4146,,affects,,Vancomycin,,,,cystic fibrosis,,,,, -16899271,4147,,affects,,Vancomycin,,,,Sepsis,,,,, -15270589,4148,,affects,,Vancomycin,,,,peritonitis,,,,, -13735180,4149,,affects,,Vancomycin,,,,pneumonia,,,,, -12348278,4150,,affects,,Vancomycin,,,,Sepsis,,,,, -12348277,4151,,affects,,Vancomycin,,,,osteomyelitis,,,,, -12348276,4152,,affects,,Vancomycin,,,,endocarditis,,,,, -7991855,4153,,affects,,Vancomycin,,,,Peptidoglycan,,,,, -7527991,4154,,affects,,Vancomycin,,,,pneumonia,,,,, -17707788,4155,,affects,,Vancomycin,,,,Peptidoglycan,,,,, -22719533,4156,,disrupts,,Vancomycin,,,,Infection,,,,, -21036263,4157,,disrupts,,Vancomycin,,,,osteomyelitis,,,,, -19924841,4158,,disrupts,,Vancomycin,,,,Inflammation,,,,, -14538194,4159,,disrupts,,Vancomycin,,,,enterocolitis,,,,, -21888394,4160,,prevents,,Vancomycin,,,,bacterial infectious disease,,,,, -21518539,4161,,prevents,,Vancomycin,,,,Infection,,,,, -21292683,4162,,prevents,,Vancomycin,,,,osteomyelitis,,,,, -20759704,4163,,prevents,,Vancomycin,,,,kidney failure,,,,, -20759520,4164,,prevents,,Vancomycin,,,,arthropathy,,,,, -16424860,4165,,prevents,,Vancomycin,,,,pneumonia,,,,, -11136130,4166,,prevents,,Vancomycin,,,,nosocomial infection,,,,, -8520533,4167,,prevents,,Vancomycin,,,,peritonitis,,,,, -8203212,4168,,prevents,,Vancomycin,,,,endocarditis,,,,, -8170423,4169,,prevents,,Vancomycin,,,,Neonatal sepsis,,,,, -8170420,4170,,prevents,,Vancomycin,,,,Sepsis,,,,, -7111089,4171,,prevents,,Vancomycin,,,,Inflammation,,,,, -25178384,4172,,exacerbates,,Vancomycin,,,,Inflammation,,,,, -21622859,4173,,exacerbates,,Vancomycin,,,,pneumonia,,,,, -21314122,4174,,predisposes,,Vancomycin,,,,Sepsis,,,,, -19879549,4175,,predisposes,,Vancomycin,,,,kidney failure,,,,, -18555479,4176,,predisposes,,Vancomycin,,,,pneumonia,,,,, -18327103,4177,,predisposes,,Vancomycin,,,,nosocomial infection,,,,, -12689487,4178,,predisposes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, -12018679,4179,,related to,,LENOGRASTIM,,,,plasma cell myeloma,,,,, -24207855,4180,,related to,,SARGRAMOSTIM,,,,pulmonary alveolar proteinosis,,,,, -23712911,4181,,related to,,SARGRAMOSTIM,,,,Sepsis,,,,, -23712910,4182,,related to,,SARGRAMOSTIM,,,,adult acute respiratory distress syndrome,,,,, -23177848,4183,,related to,,SARGRAMOSTIM,,,,Alzheimer disease,,,,, -16827749,4184,,related to,,SARGRAMOSTIM,,,,prostate cancer,,,,, -11846978,4185,,related to,,SARGRAMOSTIM,,,,Crohn disease,,,,, -7671811,4186,,related to,,SARGRAMOSTIM,,,,HIV infectious disease,,,,, -7896656,4187,,prevents,,SARGRAMOSTIM,,,,neutropenia,,,,, -27611311,4188,,related to,,Filgrastim,,,,sarcoma,,,,, -26602673,4189,,related to,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, -26505391,4190,,related to,,Filgrastim,,,,Hodgkins lymphoma,,,,, -23038064,4191,,related to,,Filgrastim,,,,Infection,,,,, -22749433,4192,,related to,,Filgrastim,,,,neoplasm,,,,, -19713781,4193,,related to,,Filgrastim,,,,lymphoma,,,,, -18903615,4194,,related to,,Filgrastim,,,,HIV infectious disease,,,,, -17402873,4195,,related to,,Filgrastim,,,,acute myeloid leukemia,,,,, -16080456,4196,,related to,,Filgrastim,,,,plasma cell myeloma,,,,, -14467347,4197,,related to,,Filgrastim,,,,myocardial infarction,,,,, -13860825,4198,,related to,,Filgrastim,,,,small cell lung carcinoma,,,,, -10253688,4199,,related to,,Filgrastim,,,,ovarian cancer,,,,, -9334871,4200,,related to,,Filgrastim,,,,non-small cell lung carcinoma,,,,, -7868897,4201,,related to,,Filgrastim,,,,neutropenia,,,,, -7775323,4202,,related to,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, -13176527,4203,,has part,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, -27488127,4204,,causes,,Filgrastim,,,,acute myeloid leukemia,,,,, -26596932,4205,,causes,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, -19245347,4206,,causes,,Filgrastim,,,,myeloproliferative neoplasm,,,,, -8419399,4207,,causes,,Filgrastim,,,,neutropenia,,,,, -26496059,4208,,affects,,Filgrastim,,,,neutropenia,,,,, -15351355,4209,,affects,,Filgrastim,,,,Fever,,,,, -7868413,4210,,affects,,Filgrastim,,,,neutropenia,,,,, -9501874,4211,,disrupts,,Filgrastim,,,,neutropenia,,,,, -14309803,4212,,prevents,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, -7265196,4213,,prevents,,Filgrastim,,,,neutropenia,,,,, -16134815,4214,,predisposes,,Filgrastim,,,,hematopoietic and lymphoid system neoplasm,,,,, -14495646,4215,,predisposes,,Filgrastim,,,,neutropenia,,,,, -12306052,4216,,affects,,Tibolone,,,,physiological sexual disorder,,,,, -7873396,4217,,prevents,,Tibolone,,,,osteoporosis,,,,, -17565484,4218,,affects,,Cosyntropin,,,,West syndrome,,,,, -11757081,4219,,disrupts,,Cosyntropin,,,,hypertensive disorder,,,,, -19585114,4220,,related to,,Corticotropin,,,,chronic progressive multiple sclerosis,,,,, -15839924,4221,,related to,,Corticotropin,,,,membranous glomerulonephritis,,,,, -10947313,4222,,related to,,Corticotropin,,,,polycystic ovary syndrome,,,,, -10518316,4223,,related to,,Corticotropin,,,,dermatomyositis,,,,, -10489579,4224,,related to,,Corticotropin,,,,epilepsy,,,,, -10438408,4225,,related to,,Corticotropin,,,,nephrotic syndrome,,,,, -10431205,4226,,related to,,Corticotropin,,,,sarcoidosis,,,,, -10427009,4227,,related to,,Corticotropin,,,,optic neuritis,,,,, -9718321,4228,,related to,,Corticotropin,,,,rheumatoid arthritis,,,,, -8496620,4229,,related to,,Corticotropin,,,,multiple sclerosis,,,,, -7394246,4230,,related to,,Corticotropin,,,,West syndrome,,,,, -22849896,4231,,causes,,Corticotropin,,,,West syndrome,,,,, -12436107,4232,,causes,,Corticotropin,,,,epilepsy,,,,, -11010111,4233,,causes,,Corticotropin,,,,rheumatoid arthritis,,,,, -17565428,4234,,affects,,Corticotropin,,,,West syndrome,,,,, -15783986,4235,,affects,,Corticotropin,,,,multiple sclerosis,,,,, -15695412,4236,,affects,,Corticotropin,,,,polycystic ovary syndrome,,,,, -11427275,4237,,affects,,Corticotropin,,,,dermatomyositis,,,,, -10737513,4238,,affects,,Corticotropin,,,,sarcoidosis,,,,, -10422766,4239,,affects,,Corticotropin,,,,rheumatoid arthritis,,,,, -9312832,4240,,affects,,Corticotropin,,,,epilepsy,,,,, -15159690,4241,,disrupts,,Corticotropin,,,,epilepsy,,,,, -27033387,4242,,prevents,,Corticotropin,,,,West syndrome,,,,, -10517176,4243,,prevents,,Corticotropin,,,,epilepsy,,,,, -23224982,4244,,predisposes,,Corticotropin,,,,epilepsy,,,,, -15800284,4245,,related to,,Dabigatran etexilate,,,,atrial fibrillation,,,,, -16972150,4246,,affects,,Dabigatran etexilate,,,,stroke disorder,,,,, -21262475,4247,,prevents,,Dabigatran etexilate,,,,thrombophilia due to thrombin defect,,,,, -19084221,4248,,prevents,,Dabigatran etexilate,,,,thrombotic disease,,,,, -14524874,4249,,prevents,,Dabigatran etexilate,,,,stroke disorder,,,,, -11599698,4250,,prevents,,Dabigatran etexilate,,,,Thromboembolism,,,,, -15929248,4251,,predisposes,,Dabigatran etexilate,,,,stroke disorder,,,,, -13343476,4252,,predisposes,,Dabigatran etexilate,,,,Thromboembolism,,,,, -10867084,4253,,related to,,Ximelagatran,,,,atrial fibrillation,,,,, -12162541,4254,,prevents,,Ximelagatran,,,,thrombotic disease,,,,, -9396435,4255,,prevents,,Ximelagatran,,,,Thromboembolism,,,,, -13148663,4256,,predisposes,,Ximelagatran,,,,Thromboembolism,,,,, -24220155,4257,,related to,,Bivalirudin,,,,Hemorrhage,,,,, -23845334,4258,,related to,,Bivalirudin,,,,thrombocytopenia,,,,, -21128552,4259,,related to,,Bivalirudin,,,,heart disorder,,,,, -16166302,4260,,related to,,Bivalirudin,,,,coronary artery disorder,,,,, -9469606,4261,,related to,,Bivalirudin,,,,myocardial infarction,,,,, -9060136,4262,,related to,,Bivalirudin,,,,acute coronary syndrome,,,,, -21743704,4263,,related to,,Bivalirudin,,,,Hemorrhage,,,,, -18003165,4264,,related to,,Bivalirudin,,,,thrombotic disease,,,,, -15575490,4265,,causes,,Bivalirudin,,,,myocardial infarction,,,,, -10298579,4266,,causes,,Bivalirudin,,,,Hemorrhage,,,,, -19056194,4267,,affects,,Bivalirudin,,,,thrombotic disease,,,,, -15575489,4268,,affects,,Bivalirudin,,,,thrombotic disease,,,,, -14748514,4269,,affects,,Bivalirudin,,,,myocardial infarction,,,,, -14318099,4270,,affects,,Bivalirudin,,,,Hemorrhage,,,,, -9597163,4271,,affects,,Bivalirudin,,,,Hemorrhage,,,,, -19316921,4272,,disrupts,,Bivalirudin,,,,myocardial infarction,,,,, -19056195,4273,,disrupts,,Bivalirudin,,,,thrombotic disease,,,,, -13525067,4274,,disrupts,,Bivalirudin,,,,acute coronary syndrome,,,,, -13434992,4275,,disrupts,,Bivalirudin,,,,Hemorrhage,,,,, -21793150,4276,,prevents,,Bivalirudin,,,,Hemorrhage,,,,, -20637086,4277,,prevents,,Bivalirudin,,,,syndromic disease,,,,, -17823880,4278,,prevents,,Bivalirudin,,,,myocardial infarction,,,,, -10215156,4279,,prevents,,Bivalirudin,,,,thrombotic disease,,,,, -22425248,4280,,predisposes,,Bivalirudin,,,,Hemorrhage,,,,, -16276306,4281,,predisposes,,Bivalirudin,,,,thrombotic disease,,,,, -14172527,4282,,predisposes,,Bivalirudin,,,,myocardial infarction,,,,, -17086386,4283,,disrupts,,Melagatran,,,,thrombotic disease,,,,, -9182682,4284,,related to,,Lepirudin,,,,thrombotic disease,,,,, -27183131,4285,,affects,,Lepirudin,,,,thrombotic disease,,,,, -26612130,4286,,disrupts,,Lepirudin,,,,thrombotic disease,,,,, -9038512,4287,,prevents,,Lepirudin,,,,thrombotic disease,,,,, -24074121,4288,,affects,,Ripasudil,,,,Fuchs' endothelial dystrophy,,,,, -23144840,4289,,prevents,,Netarsudil,,,,corneal edema,,,,, -21457868,4290,,prevents,,Netarsudil,,,,open-angle glaucoma,,,,, -25249408,4291,,related to,,Calcitriol,,,,Hypocalcemia,,,,, -24424216,4292,,related to,,Calcitriol,,,,Crohn disease,,,,, -23057137,4293,,related to,,Calcitriol,,,,acute kidney failure,,,,, -21048179,4294,,related to,,Calcitriol,,,,breast neoplasm,,,,, -18873537,4295,,related to,,Calcitriol,,,,diabetic kidney disease,,,,, -17759117,4296,,related to,,Calcitriol,,,,Sepsis,,,,, -17014883,4297,,related to,,Calcitriol,,,,hypoparathyroidism,,,,, -16783681,4298,,related to,,Calcitriol,,,,non-small cell lung carcinoma,,,,, -16670490,4299,,related to,,Calcitriol,,,,postmenopausal osteoporosis,,,,, -16084679,4300,,related to,,Calcitriol,,,,hypertensive disorder,,,,, -15183062,4301,,related to,,Calcitriol,,,,type 1 diabetes mellitus,,,,, -13574949,4302,,related to,,Calcitriol,,,,neoplasm,,,,, -13228040,4303,,related to,,Calcitriol,,,,castration-resistant prostate carcinoma,,,,, -11632117,4304,,related to,,Calcitriol,,,,prostate cancer,,,,, -11549262,4305,,related to,,Calcitriol,,,,renal osteodystrophy,,,,, -11138207,4306,,related to,,Calcitriol,,,,skin basal cell carcinoma,,,,, -9056874,4307,,related to,,Calcitriol,,,,psoriasis,,,,, -8335532,4308,,related to,,Calcitriol,,,,chronic kidney disease,,,,, -7638906,4309,,related to,,Calcitriol,,,,myelodysplastic syndrome,,,,, -7210521,4310,,related to,,Calcitriol,,,,osteoporosis,,,,, -23300761,4311,,causes,,Calcitriol,,,,hypoparathyroidism,,,,, -22190855,4312,,causes,,Calcitriol,,,,Hypocalcemia,,,,, -13672029,4313,,causes,,Calcitriol,,,,renal osteodystrophy,,,,, -8610431,4314,,causes,,Calcitriol,,,,neoplasm,,,,, -26699785,4315,,affects,,Calcitriol,,,,myelodysplastic syndrome,,,,, -26649101,4316,,affects,,Calcitriol,,,,psoriasis,,,,, -20118335,4317,,affects,,Calcitriol,,,,chronic kidney disease,,,,, -18144364,4318,,affects,,Calcitriol,,,,diabetic kidney disease,,,,, -17907580,4319,,affects,,Calcitriol,,,,breast neoplasm,,,,, -15840384,4320,,affects,,Calcitriol,,,,skin basal cell carcinoma,,,,, -15206874,4321,,affects,,Calcitriol,,,,neoplasm,,,,, -15145405,4322,,affects,,Calcitriol,,,,neoplasm,,,,, -10932246,4323,,affects,,Calcitriol,,,,chronic kidney disease,,,,, -9912093,4324,,affects,,Calcitriol,,,,prostate cancer,,,,, -9912091,4325,,affects,,Calcitriol,,,,prostate cancer,,,,, -26695789,4326,,produces,,Calcitriol,,,,renal osteodystrophy,,,,, -14288417,4327,,produces,,Calcitriol,,,,Crohn disease,,,,, -19013737,4328,,disrupts,,Calcitriol,,,,chronic kidney disease,,,,, -17492128,4329,,disrupts,,Calcitriol,,,,prostate cancer,,,,, -15711853,4330,,disrupts,,Calcitriol,,,,neoplasm,,,,, -23005720,4331,,prevents,,Calcitriol,,,,neoplasm,,,,, -22688863,4332,,prevents,,Calcitriol,,,,Hypocalcemia,,,,, -18398383,4333,,prevents,,Calcitriol,,,,diabetic kidney disease,,,,, -17492127,4334,,prevents,,Calcitriol,,,,prostate cancer,,,,, -8346486,4335,,prevents,,Calcitriol,,,,osteoporosis,,,,, -8053720,4336,,prevents,,Calcitriol,,,,postmenopausal osteoporosis,,,,, -24886178,4337,,exacerbates,,Calcitriol,,,,Sepsis,,,,, -18653087,4338,,exacerbates,,Calcitriol,,,,hypertensive disorder,,,,, -21373396,4339,,predisposes,,Calcitriol,,,,chronic kidney disease,,,,, -17377804,4340,,predisposes,,Calcitriol,,,,hypertensive disorder,,,,, -16828204,4341,,predisposes,,Calcitriol,,,,osteoporosis,,,,, -9760670,4342,,predisposes,,Calcitriol,,,,prostate cancer,,,,, -26462827,4343,,related to,,Alfacalcidol,,,,kidney failure,,,,, -9037270,4344,,related to,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, -7210524,4345,,related to,,Alfacalcidol,,,,osteoporosis,,,,, -22711685,4346,,causes,,Alfacalcidol,,,,osteoporosis,,,,, -26635675,4347,,affects,,Alfacalcidol,,,,kidney failure,,,,, -21927698,4348,,affects,,Alfacalcidol,,,,myopathy,,,,, -11900508,4349,,affects,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, -8505855,4350,,affects,,Alfacalcidol,,,,osteoporosis,,,,, -20641062,4351,,disrupts,,Alfacalcidol,,,,osteoporosis,,,,, -21927699,4352,,prevents,,Alfacalcidol,,,,myopathy,,,,, -7684744,4353,,prevents,,Alfacalcidol,,,,osteoporosis,,,,, -7684734,4354,,prevents,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, -24020567,4355,,related to,,Cholecalciferol,,,,male infertility,,,,, -23185349,4356,,related to,,Cholecalciferol,,,,ulcerative colitis,,,,, -22584995,4357,,related to,,Cholecalciferol,,,,acute myeloid leukemia,,,,, -21514930,4358,,related to,,Cholecalciferol,,,,Infection,,,,, -21254434,4359,,related to,,Cholecalciferol,,,,depressive disorder,,,,, -20389616,4360,,related to,,Cholecalciferol,,,,anemia,,,,, -20190699,4361,,related to,,Cholecalciferol,,,,autism spectrum disorder,,,,, -19639056,4362,,related to,,Cholecalciferol,,,,pulmonary tuberculosis,,,,, -18980881,4363,,related to,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, -18889413,4364,,related to,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, -18830431,4365,,related to,,Cholecalciferol,,,,prostate cancer,,,,, -18776998,4366,,related to,,Cholecalciferol,,,,epilepsy,,,,, -18009382,4367,,related to,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, -17581366,4368,,related to,,Cholecalciferol,,,,vitamin D deficiency,,,,, -17374616,4369,,related to,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, -17169513,4370,,related to,,Cholecalciferol,,,,Parkinson disease,,,,, -17054911,4371,,related to,,Cholecalciferol,,,,tuberculosis,,,,, -16909919,4372,,related to,,Cholecalciferol,,,,inflammatory bowel disease,,,,, -16219443,4373,,related to,,Cholecalciferol,,,,"dermatitis, atopic",,,,, -16115730,4374,,related to,,Cholecalciferol,,,,cardiovascular disorder,,,,, -15133291,4375,,related to,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -14512631,4376,,related to,,Cholecalciferol,,,,hyperparathyroidism,,,,, -13680137,4377,,related to,,Cholecalciferol,,,,multiple sclerosis,,,,, -13562951,4378,,related to,,Cholecalciferol,,,,metabolic syndrome X,,,,, -13562949,4379,,related to,,Cholecalciferol,,,,obesity disorder,,,,, -13035326,4380,,related to,,Cholecalciferol,,,,bone fracture,,,,, -11935565,4381,,related to,,Cholecalciferol,,,,osteoporosis,,,,, -11152529,4382,,related to,,Cholecalciferol,,,,diabetes mellitus,,,,, -10386853,4383,,related to,,Cholecalciferol,,,,Crohn disease,,,,, -9703967,4384,,related to,,Cholecalciferol,,,,melanoma,,,,, -9414232,4385,,related to,,Cholecalciferol,,,,psoriasis,,,,, -8798994,4386,,related to,,Cholecalciferol,,,,hip fracture,,,,, -20878953,4387,,causes,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, -20469671,4388,,causes,,Cholecalciferol,,,,tuberculosis,,,,, -20417553,4389,,causes,,Cholecalciferol,,,,psoriasis,,,,, -19411734,4390,,causes,,Cholecalciferol,,,,"dermatitis, atopic",,,,, -17854537,4391,,causes,,Cholecalciferol,,,,neoplasm,,,,, -15944158,4392,,causes,,Cholecalciferol,,,,vitamin D deficiency,,,,, -13998286,4393,,causes,,Cholecalciferol,,,,depressive disorder,,,,, -27560876,4394,,affects,,Cholecalciferol,,,,prostate cancer,,,,, -22640117,4395,,affects,,Cholecalciferol,,,,severe acute respiratory syndrome,,,,, -21843529,4396,,affects,,Cholecalciferol,,,,Pregnancy,,,,, -21703950,4397,,affects,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -20945952,4398,,affects,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, -20733345,4399,,affects,,Cholecalciferol,,,,epilepsy,,,,, -20612106,4400,,affects,,Cholecalciferol,,,,Cognitive impairment,,,,, -19925618,4401,,affects,,Cholecalciferol,,,,asthma,,,,, -19815601,4402,,affects,,Cholecalciferol,,,,ulcerative colitis,,,,, -19556148,4403,,affects,,Cholecalciferol,,,,neoplasm,,,,, -19132727,4404,,affects,,Cholecalciferol,,,,obesity disorder,,,,, -18122364,4405,,affects,,Cholecalciferol,,,,metabolic syndrome X,,,,, -18122363,4406,,affects,,Cholecalciferol,,,,cardiovascular disorder,,,,, -17715748,4407,,affects,,Cholecalciferol,,,,hip fracture,,,,, -17674517,4408,,affects,,Cholecalciferol,,,,Pregnancy,,,,, -17585577,4409,,affects,,Cholecalciferol,,,,depressive disorder,,,,, -17451551,4410,,affects,,Cholecalciferol,,,,neoplasm,,,,, -16299943,4411,,affects,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, -16007821,4412,,affects,,Cholecalciferol,,,,psoriasis,,,,, -15977971,4413,,affects,,Cholecalciferol,,,,melanoma,,,,, -15944152,4414,,affects,,Cholecalciferol,,,,osteoporosis,,,,, -15393278,4415,,affects,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, -15170889,4416,,affects,,Cholecalciferol,,,,multiple sclerosis,,,,, -13518388,4417,,affects,,Cholecalciferol,,,,bone fracture,,,,, -21045274,4418,,produces,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -17840044,4419,,produces,,Cholecalciferol,,,,inflammatory bowel disease,,,,, -20733344,4420,,disrupts,,Cholecalciferol,,,,epilepsy,,,,, -19044664,4421,,disrupts,,Cholecalciferol,,,,AIDS,,,,, -15558469,4422,,disrupts,,Cholecalciferol,,,,HIV infectious disease,,,,, -14834931,4423,,disrupts,,Cholecalciferol,,,,neoplasm,,,,, -14617748,4424,,disrupts,,Cholecalciferol,,,,multiple sclerosis,,,,, -14491908,4425,,disrupts,,Cholecalciferol,,,,vitamin D deficiency,,,,, -11194374,4426,,disrupts,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -25419746,4427,,prevents,,Cholecalciferol,,,,Infection,,,,, -23552226,4428,,prevents,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, -23324302,4429,,prevents,,Cholecalciferol,,,,ulcerative colitis,,,,, -22418643,4430,,prevents,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, -22340834,4431,,prevents,,Cholecalciferol,,,,depressive disorder,,,,, -20959064,4432,,prevents,,Cholecalciferol,,,,postmenopausal osteoporosis,,,,, -20699168,4433,,prevents,,Cholecalciferol,,,,cardiovascular disorder,,,,, -19389521,4434,,prevents,,Cholecalciferol,,,,epilepsy,,,,, -18282049,4435,,prevents,,Cholecalciferol,,,,inherited lipid metabolism disorder,,,,, -17951280,4436,,prevents,,Cholecalciferol,,,,anemia,,,,, -17701830,4437,,prevents,,Cholecalciferol,,,,influenza,,,,, -15773595,4438,,prevents,,Cholecalciferol,,,,neoplasm,,,,, -15663430,4439,,prevents,,Cholecalciferol,,,,diabetes mellitus,,,,, -12943427,4440,,prevents,,Cholecalciferol,,,,vitamin D deficiency,,,,, -11194373,4441,,prevents,,Cholecalciferol,,,,osteoporosis,,,,, -11017561,4442,,prevents,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -10503621,4443,,prevents,,Cholecalciferol,,,,bone fracture,,,,, -9458588,4444,,prevents,,Cholecalciferol,,,,hip fracture,,,,, -21072124,4445,,predisposes,,Cholecalciferol,,,,metabolic syndrome X,,,,, -18104348,4446,,predisposes,,Cholecalciferol,,,,colorectal neoplasm,,,,, -17901013,4447,,predisposes,,Cholecalciferol,,,,bone fracture,,,,, -17714481,4448,,predisposes,,Cholecalciferol,,,,asthma,,,,, -17184810,4449,,predisposes,,Cholecalciferol,,,,multiple sclerosis,,,,, -15110409,4450,,predisposes,,Cholecalciferol,,,,vitamin D deficiency,,,,, -13562954,4451,,predisposes,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, -9524358,4452,,predisposes,,Cholecalciferol,,,,hip fracture,,,,, -9314384,4453,,predisposes,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -27330803,4454,,related to,,Ergocalciferol,,,,Familial hypophosphatemia,,,,, -26089502,4455,,related to,,Ergocalciferol,,,,osteogenesis imperfecta,,,,, -22199149,4456,,related to,,Ergocalciferol,,,,Hypocalcemia,,,,, -22194600,4457,,related to,,Ergocalciferol,,,,severe acute respiratory syndrome,,,,, -21840711,4458,,related to,,Ergocalciferol,,,,castration-resistant prostate carcinoma,,,,, -21543726,4459,,related to,,Ergocalciferol,,,,sarcopenia,,,,, -21516783,4460,,related to,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, -21478252,4461,,related to,,Ergocalciferol,,,,bone fracture,,,,, -21128214,4462,,related to,,Ergocalciferol,,,,bone Paget disease,,,,, -20256197,4463,,related to,,Ergocalciferol,,,,restless legs syndrome,,,,, -19853448,4464,,related to,,Ergocalciferol,,,,neuralgia,,,,, -19595978,4465,,related to,,Ergocalciferol,,,,hepatitis C virus infection,,,,, -19221334,4466,,related to,,Ergocalciferol,,,,spinal cord injury,,,,, -18303138,4467,,related to,,Ergocalciferol,,,,optic neuritis,,,,, -17457750,4468,,related to,,Ergocalciferol,,,,migraine disorder,,,,, -17248671,4469,,related to,,Ergocalciferol,,,,diffuse alopecia areata,,,,, -16231683,4470,,related to,,Ergocalciferol,,,,chronic hepatitis C virus infection,,,,, -16050991,4471,,related to,,Ergocalciferol,,,,lung neoplasm,,,,, -15954794,4472,,related to,,Ergocalciferol,,,,femoral neck fracture,,,,, -15739454,4473,,related to,,Ergocalciferol,,,,diabetic neuropathy,,,,, -15603622,4474,,related to,,Ergocalciferol,,,,HIV infectious disease,,,,, -15306422,4475,,related to,,Ergocalciferol,,,,blood coagulation disease,,,,, -15165807,4476,,related to,,Ergocalciferol,,,,postmenopausal osteoporosis,,,,, -14949967,4477,,related to,,Ergocalciferol,,,,Premature birth,,,,, -14949966,4478,,related to,,Ergocalciferol,,,,gestational diabetes,,,,, -14870236,4479,,related to,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, -14594285,4480,,related to,,Ergocalciferol,,,,colorectal neoplasm,,,,, -14321159,4481,,related to,,Ergocalciferol,,,,asthma,,,,, -13975664,4482,,related to,,Ergocalciferol,,,,cutaneous lupus erythematosus,,,,, -13939480,4483,,related to,,Ergocalciferol,,,,mood disorder,,,,, -13895667,4484,,related to,,Ergocalciferol,,,,sudden cardiac arrest,,,,, -13383363,4485,,related to,,Ergocalciferol,,,,sickle cell anemia,,,,, -13199782,4486,,related to,,Ergocalciferol,,,,Alzheimer disease,,,,, -12834035,4487,,related to,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -12803681,4488,,related to,,Ergocalciferol,,,,Insulin resistance,,,,, -12377378,4489,,related to,,Ergocalciferol,,,,non-Hodgkin lymphoma,,,,, -12131992,4490,,related to,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -11979233,4491,,related to,,Ergocalciferol,,,,leukemia,,,,, -11933002,4492,,related to,,Ergocalciferol,,,,Pain,,,,, -11653558,4493,,related to,,Ergocalciferol,,,,melanoma,,,,, -11434397,4494,,related to,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -11002964,4495,,related to,,Ergocalciferol,,,,pulmonary tuberculosis,,,,, -10894479,4496,,related to,,Ergocalciferol,,,,Crohn disease,,,,, -10768947,4497,,related to,,Ergocalciferol,,,,hip fracture,,,,, -10183383,4498,,related to,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -10168534,4499,,related to,,Ergocalciferol,,,,tuberculosis,,,,, -10066878,4500,,related to,,Ergocalciferol,,,,lymphoma,,,,, -9770434,4501,,related to,,Ergocalciferol,,,,neoplasm,,,,, -9499640,4502,,related to,,Ergocalciferol,,,,hypoparathyroidism,,,,, -9487308,4503,,related to,,Ergocalciferol,,,,myocardial ischemia,,,,, -9462983,4504,,related to,,Ergocalciferol,,,,ulcerative colitis,,,,, -9176947,4505,,related to,,Ergocalciferol,,,,psoriasis,,,,, -9137351,4506,,related to,,Ergocalciferol,,,,nutritional disorder,,,,, -8792180,4507,,related to,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -8116213,4508,,related to,,Ergocalciferol,,,,obesity disorder,,,,, -8093753,4509,,related to,,Ergocalciferol,,,,vitamin D deficiency,,,,, -8061037,4510,,related to,,Ergocalciferol,,,,multiple sclerosis,,,,, -8061036,4511,,related to,,Ergocalciferol,,,,diabetes mellitus,,,,, -7613246,4512,,related to,,Ergocalciferol,,,,osteoporosis,,,,, -7587226,4513,,related to,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, -7252642,4514,,related to,,Ergocalciferol,,,,prostate cancer,,,,, -26403196,4515,,causes,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -25624374,4516,,causes,,Ergocalciferol,,,,leukemia,,,,, -25513025,4517,,causes,,Ergocalciferol,,,,restless legs syndrome,,,,, -25147512,4518,,causes,,Ergocalciferol,,,,sarcopenia,,,,, -21420546,4519,,causes,,Ergocalciferol,,,,diabetic neuropathy,,,,, -21344725,4520,,causes,,Ergocalciferol,,,,diffuse alopecia areata,,,,, -19221130,4521,,causes,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, -19022139,4522,,causes,,Ergocalciferol,,,,gestational diabetes,,,,, -18967408,4523,,causes,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, -18875338,4524,,causes,,Ergocalciferol,,,,psoriasis,,,,, -18041148,4525,,causes,,Ergocalciferol,,,,Crohn disease,,,,, -16369420,4526,,causes,,Ergocalciferol,,,,neoplasm,,,,, -16017645,4527,,causes,,Ergocalciferol,,,,obesity disorder,,,,, -15862130,4528,,causes,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -15179909,4529,,causes,,Ergocalciferol,,,,asthma,,,,, -14594790,4530,,causes,,Ergocalciferol,,,,Insulin resistance,,,,, -14004176,4531,,causes,,Ergocalciferol,,,,Pain,,,,, -12191251,4532,,causes,,Ergocalciferol,,,,osteoporosis,,,,, -11612180,4533,,causes,,Ergocalciferol,,,,colorectal neoplasm,,,,, -11557471,4534,,causes,,Ergocalciferol,,,,vitamin D deficiency,,,,, -11557464,4535,,causes,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -11275618,4536,,causes,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -10362733,4537,,causes,,Ergocalciferol,,,,multiple sclerosis,,,,, -8719466,4538,,causes,,Ergocalciferol,,,,diabetes mellitus,,,,, -8407906,4539,,causes,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -7553325,4540,,causes,,Ergocalciferol,,,,prostate cancer,,,,, -7357695,4541,,causes,,Ergocalciferol,,,,bone fracture,,,,, -25936029,4542,,affects,,Ergocalciferol,,,,nutritional disorder,,,,, -25430100,4543,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -24682916,4544,,affects,,Ergocalciferol,,,,bone fracture,,,,, -24133915,4545,,affects,,Ergocalciferol,,,,HIV infectious disease,,,,, -23716846,4546,,affects,,Ergocalciferol,,,,Premature birth,,,,, -22436428,4547,,affects,,Ergocalciferol,,,,obesity disorder,,,,, -22382447,4548,,affects,,Ergocalciferol,,,,Pregnancy,,,,, -21132793,4549,,affects,,Ergocalciferol,,,,breast neoplasm,,,,, -20959246,4550,,affects,,Ergocalciferol,,,,diabetes mellitus,,,,, -20298561,4551,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -20058982,4552,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, -19907316,4553,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, -19815602,4554,,affects,,Ergocalciferol,,,,ulcerative colitis,,,,, -19320344,4555,,affects,,Ergocalciferol,,,,Premature birth,,,,, -19221129,4556,,affects,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, -18424308,4557,,affects,,Ergocalciferol,,,,vitamin D deficiency,,,,, -18115621,4558,,affects,,Ergocalciferol,,,,asthma,,,,, -17654393,4559,,affects,,Ergocalciferol,,,,optic neuritis,,,,, -17646826,4560,,affects,,Ergocalciferol,,,,migraine disorder,,,,, -17581908,4561,,affects,,Ergocalciferol,,,,Pain,,,,, -17056932,4562,,affects,,Ergocalciferol,,,,sarcopenia,,,,, -16630786,4563,,affects,,Ergocalciferol,,,,sarcopenia,,,,, -16542255,4564,,affects,,Ergocalciferol,,,,melanoma,,,,, -16343274,4565,,affects,,Ergocalciferol,,,,restless legs syndrome,,,,, -16273798,4566,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, -16273796,4567,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -15812657,4568,,affects,,Ergocalciferol,,,,prostate cancer,,,,, -15750325,4569,,affects,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, -15694248,4570,,affects,,Ergocalciferol,,,,mood disorder,,,,, -15543952,4571,,affects,,Ergocalciferol,,,,osteoporosis,,,,, -15528071,4572,,affects,,Ergocalciferol,,,,Alzheimer disease,,,,, -15258155,4573,,affects,,Ergocalciferol,,,,obesity disorder,,,,, -14609756,4574,,affects,,Ergocalciferol,,,,tuberculosis,,,,, -14384550,4575,,affects,,Ergocalciferol,,,,psoriasis,,,,, -14233188,4576,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, -13916047,4577,,affects,,Ergocalciferol,,,,hip fracture,,,,, -13794313,4578,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, -13764162,4579,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -13437693,4580,,affects,,Ergocalciferol,,,,Crohn disease,,,,, -13211992,4581,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -13015298,4582,,affects,,Ergocalciferol,,,,asthma,,,,, -12698804,4583,,affects,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, -12502345,4584,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -12032067,4585,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, -11831475,4586,,affects,,Ergocalciferol,,,,bone fracture,,,,, -10991167,4587,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -10917919,4588,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -10608353,4589,,affects,,Ergocalciferol,,,,Pregnancy,,,,, -8987937,4590,,affects,,Ergocalciferol,,,,hip fracture,,,,, -8925552,4591,,affects,,Ergocalciferol,,,,prostate cancer,,,,, -8894668,4592,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -8321224,4593,,affects,,Ergocalciferol,,,,neoplasm,,,,, -7878820,4594,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -21952380,4595,,produces,,Ergocalciferol,,,,obesity disorder,,,,, -21636964,4596,,produces,,Ergocalciferol,,,,asthma,,,,, -20636497,4597,,produces,,Ergocalciferol,,,,Pregnancy,,,,, -20444810,4598,,produces,,Ergocalciferol,,,,Alzheimer disease,,,,, -15318015,4599,,produces,,Ergocalciferol,,,,melanoma,,,,, -14384547,4600,,produces,,Ergocalciferol,,,,psoriasis,,,,, \ No newline at end of file +23573980,501,,related to,,Methylprednisolone,,,,pneumonia,,,,, +23514846,502,,related to,,Methylprednisolone,,,,carpal tunnel syndrome,,,,, +23364897,503,,related to,,Methylprednisolone,,,,West syndrome,,,,, +22495910,504,,related to,,Methylprednisolone,,,,myocarditis,,,,, +22175056,505,,related to,,Methylprednisolone,,,,myopathy,,,,, +20879022,506,,related to,,Methylprednisolone,,,,Pain,,,,, +20342058,507,,related to,,Methylprednisolone,,,,chronic progressive multiple sclerosis,,,,, +20290784,508,,related to,,Methylprednisolone,,,,membranous glomerulonephritis,,,,, +20286711,509,,related to,,Methylprednisolone,,,,neuromyelitis optica,,,,, +19340184,510,,related to,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, +18938435,511,,related to,,Methylprednisolone,,,,graft versus host disease,,,,, +17333962,512,,related to,,Methylprednisolone,,,,Inflammation,,,,, +17288506,513,,related to,,Methylprednisolone,,,,autoimmune thrombocytopenic purpura,,,,, +15936572,514,,related to,,Methylprednisolone,,,,endocrine exophthalmos,,,,, +15072844,515,,related to,,Methylprednisolone,,,,Edema,,,,, +14876749,516,,related to,,Methylprednisolone,,,,osteoarthritis,,,,, +14399082,517,,related to,,Methylprednisolone,,,,aplastic anemia,,,,, +14398237,518,,related to,,Methylprednisolone,,,,IgA glomerulonephritis,,,,, +14278238,519,,related to,,Methylprednisolone,,,,"dermatitis, atopic",,,,, +14166179,520,,related to,,Methylprednisolone,,,,cardiac arrest,,,,, +12755316,521,,related to,,Methylprednisolone,,,,plasma cell myeloma,,,,, +12183687,522,,related to,,Methylprednisolone,,,,acute lymphoblastic leukemia,,,,, +11720471,523,,related to,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, +10812685,524,,related to,,Methylprednisolone,,,,immunoglobulin a vasculitis,,,,, +10763477,525,,related to,,Methylprednisolone,,,,ulcerative colitis,,,,, +10558884,526,,related to,,Methylprednisolone,,,,lupus nephritis,,,,, +10130342,527,,related to,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, +9229208,528,,related to,,Methylprednisolone,,,,vestibular neuronitis,,,,, +9003326,529,,related to,,Methylprednisolone,,,,systemic sclerosis,,,,, +8447481,530,,related to,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +8282330,531,,related to,,Methylprednisolone,,,,spinal cord injury,,,,, +7944646,532,,related to,,Methylprednisolone,,,,myasthenia gravis,,,,, +7668599,533,,related to,,Methylprednisolone,,,,multiple sclerosis,,,,, +7443745,534,,related to,,Methylprednisolone,,,,asthma,,,,, +24973247,535,,causes,,Methylprednisolone,,,,lupus nephritis,,,,, +24161886,536,,causes,,Methylprednisolone,,,,Edema,,,,, +18534953,537,,causes,,Methylprednisolone,,,,Inflammation,,,,, +18260665,538,,causes,,Methylprednisolone,,,,neoplasm,,,,, +17307095,539,,causes,,Methylprednisolone,,,,pneumonia,,,,, +15906641,540,,causes,,Methylprednisolone,,,,Pain,,,,, +13166073,541,,causes,,Methylprednisolone,,,,thrombocytopenia,,,,, +12672767,542,,causes,,Methylprednisolone,,,,drug-induced liver injury,,,,, +8525599,543,,causes,,Methylprednisolone,,,,myopathy,,,,, +27357949,544,,affects,,Methylprednisolone,,,,neoplasm,,,,, +24420470,545,,affects,,Methylprednisolone,,,,Inflammation,,,,, +23472756,546,,affects,,Methylprednisolone,,,,Inflammation,,,,, +20530617,547,,affects,,Methylprednisolone,,,,systemic sclerosis,,,,, +20254789,548,,affects,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, +17649050,549,,affects,,Methylprednisolone,,,,optic nerve disorder,,,,, +16634377,550,,affects,,Methylprednisolone,,,,myasthenia gravis,,,,, +16277488,551,,affects,,Methylprednisolone,,,,neuromyelitis optica,,,,, +15906642,552,,affects,,Methylprednisolone,,,,Pain,,,,, +15610554,553,,affects,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +15186368,554,,affects,,Methylprednisolone,,,,graft versus host disease,,,,, +14891106,555,,affects,,Methylprednisolone,,,,kidney disorder,,,,, +11819955,556,,affects,,Methylprednisolone,,,,spinal cord injury,,,,, +10845505,557,,affects,,Methylprednisolone,,,,Pain,,,,, +10048898,558,,affects,,Methylprednisolone,,,,ulcerative colitis,,,,, +9646753,559,,affects,,Methylprednisolone,,,,multiple sclerosis,,,,, +9346353,560,,affects,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, +9107378,561,,affects,,Methylprednisolone,,,,Edema,,,,, +8596544,562,,affects,,Methylprednisolone,,,,asthma,,,,, +8330909,563,,affects,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, +19744632,564,,disrupts,,Methylprednisolone,,,,Edema,,,,, +18407557,565,,disrupts,,Methylprednisolone,,,,thrombocytopenia,,,,, +11106658,566,,disrupts,,Methylprednisolone,,,,Pain,,,,, +8640603,567,,disrupts,,Methylprednisolone,,,,Inflammation,,,,, +23934495,568,,prevents,,Methylprednisolone,,,,Cognitive impairment,,,,, +20014108,569,,prevents,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +18266414,570,,prevents,,Methylprednisolone,,,,Abdominal pain,,,,, +14967074,571,,prevents,,Methylprednisolone,,,,asthma,,,,, +9744990,572,,prevents,,Methylprednisolone,,,,ovarian hyperstimulation syndrome,,,,, +8345063,573,,prevents,,Methylprednisolone,,,,Pain,,,,, +8291272,574,,prevents,,Methylprednisolone,,,,graft versus host disease,,,,, +7980138,575,,prevents,,Methylprednisolone,,,,spinal cord injury,,,,, +7414405,576,,prevents,,Methylprednisolone,,,,Edema,,,,, +18106042,577,,predisposes,,Methylprednisolone,,,,pneumonia,,,,, +9645180,578,,predisposes,,Methylprednisolone,,,,Inflammation,,,,, +12905337,579,,related to,,Cefotaxime,,,,Sepsis,,,,, +24475300,580,,affects,,Cefotaxime,,,,bacterial infectious disease,,,,, +23922029,581,,affects,,Cefotaxime,,,,Sepsis,,,,, +18672205,582,,affects,,Cefotaxime,,,,peritonitis,,,,, +15853591,583,,prevents,,Cefotaxime,,,,Sepsis,,,,, +19081412,584,,prevents,,Ceftriaxone,,,,bacterial infectious disease,,,,, +25827448,585,,related to,,Gefarnate,,,,gastric ulcer,,,,, +24296137,586,,related to,,Gefarnate,,,,duodenal ulcer,,,,, +25993651,587,,disrupts,,Gefarnate,,,,gastric ulcer,,,,, +17758516,588,,related to,,Neobiotic,,,,Inflammation,,,,, +10690423,589,,related to,,Neobiotic,,,,burn,,,,, +20263460,590,,affects,,Neobiotic,,,,neoplasm,,,,, +19744068,591,,affects,,Neobiotic,,,,Inflammation,,,,, +24669492,592,,disrupts,,Neobiotic,,,,bacterial infectious disease,,,,, +17119153,593,,disrupts,,Neobiotic,,,,neoplasm,,,,, +26428369,594,,prevents,,Neobiotic,,,,bacterial infectious disease,,,,, +25579460,595,,related to,,BLINATUMOMAB,,,,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,,,,, +22474123,596,,related to,,BLINATUMOMAB,,,,hematopoietic and lymphoid system neoplasm,,,,, +21947892,597,,related to,,BLINATUMOMAB,,,,acute lymphoblastic leukemia,,,,, +27155094,598,,related to,,Ciprofloxacin,,,,endophthalmitis,,,,, +16836665,599,,related to,,Ciprofloxacin,,,,Crohn disease,,,,, +19572117,600,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, +19572117,601,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, +12385742,602,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +12385742,603,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +17007621,604,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +17007621,605,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +9387116,606,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +8212496,607,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +25648466,608,,causes,,Ciprofloxacin,,,,abscess,,,,, +24716241,609,,causes,,Ciprofloxacin,,,,peritonitis,,,,, +17154464,610,,causes,,Ciprofloxacin,,,,prostatitis,,,,, +14369807,611,,causes,,Ciprofloxacin,,,,neutropenia,,,,, +13950319,612,,causes,,Ciprofloxacin,,,,pneumonia,,,,, +10209213,613,,causes,,Ciprofloxacin,,,,infectious disease,,,,, +7113733,614,,causes,,Ciprofloxacin,,,,osteomyelitis,,,,, +21996198,615,,affects,,Ciprofloxacin,,,,infectious disease,,,,, +16563368,616,,affects,,Ciprofloxacin,,,,Fever,,,,, +16125923,617,,affects,,Ciprofloxacin,,,,osteomyelitis,,,,, +12942741,618,,affects,,Ciprofloxacin,,,,Crohn disease,,,,, +11440816,619,,affects,,Ciprofloxacin,,,,typhoid fever,,,,, +11267024,620,,affects,,Ciprofloxacin,,,,eye infectious disorder,,,,, +10672042,621,,affects,,Ciprofloxacin,,,,Abdominal Infection,,,,, +9891814,622,,affects,,Ciprofloxacin,,,,pneumonia,,,,, +9122989,623,,affects,,Ciprofloxacin,,,,infectious disease,,,,, +8956826,624,,affects,,Ciprofloxacin,,,,Pseudomonas infection,,,,, +8956825,625,,affects,,Ciprofloxacin,,,,cystic fibrosis,,,,, +8669720,626,,affects,,Ciprofloxacin,,,,Fever,,,,, +7886704,627,,affects,,Ciprofloxacin,,,,bronchiectasis,,,,, +7886701,628,,affects,,Ciprofloxacin,,,,chronic bronchitis,,,,, +7781719,629,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, +7592205,630,,affects,,Ciprofloxacin,,,,chronic obstructive pulmonary disease,,,,, +18400322,631,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, +26984478,632,,disrupts,,Ciprofloxacin,,,,Fever,,,,, +26466958,633,,disrupts,,Ciprofloxacin,,,,pneumonia,,,,, +18480207,634,,disrupts,,Ciprofloxacin,,,,infectious disease,,,,, +10323767,635,,disrupts,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, +27242944,636,,prevents,,Ciprofloxacin,,,,pyelonephritis,,,,, +21807033,637,,prevents,,Ciprofloxacin,,,,Infection,,,,, +16138544,638,,prevents,,Ciprofloxacin,,,,diarrheal disease,,,,, +15438014,639,,prevents,,Ciprofloxacin,,,,Sepsis,,,,, +14202377,640,,prevents,,Ciprofloxacin,,,,plague,,,,, +12292532,641,,prevents,,Ciprofloxacin,,,,endophthalmitis,,,,, +10767980,642,,prevents,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, +9947057,643,,prevents,,Ciprofloxacin,,,,bacterial infectious disease,,,,, +8364719,644,,prevents,,Ciprofloxacin,,,,pneumonia,,,,, +8054296,645,,prevents,,Ciprofloxacin,,,,infectious disease,,,,, +18366035,646,,predisposes,,Ciprofloxacin,,,,infectious disease,,,,, +15459841,647,,predisposes,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, +8758764,648,,predisposes,,Ciprofloxacin,,,,gonorrhea,,,,, +15493028,649,,disrupts,,Chloramphenicol,,,,acne,,,,, +21241586,650,,prevents,,Chloramphenicol,,,,eye infectious disorder,,,,, +16722213,651,,causes,,Rebamipide,,,,osteoarthritis,,,,, +27679650,652,,affects,,Rebamipide,,,,peptic ulcer disease,,,,, +10125846,653,,affects,,Rebamipide,,,,gastric ulcer,,,,, +16923576,654,,disrupts,,Rebamipide,,,,gastritis,,,,, +20953135,655,,prevents,,Rebamipide,,,,peptic ulcer disease,,,,, +13727344,656,,prevents,,Rebamipide,,,,gastritis,,,,, +10452606,657,,prevents,,Rebamipide,,,,gastric ulcer,,,,, +23020953,658,,related to,,DINUTUXIMAB,,,,neoplasm,,,,, +12385638,659,,related to,,DINUTUXIMAB,,,,neuroblastoma,,,,, +21974466,660,,causes,,DINUTUXIMAB,,,,neuroblastoma,,,,, +23929422,661,,related to,,BRENTUXIMAB VEDOTIN,,,,anaplastic large cell lymphoma,,,,, +23730531,662,,related to,,BRENTUXIMAB VEDOTIN,,,,mycosis fungoides,,,,, +23653011,663,,related to,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, +23065539,664,,related to,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, +21812241,665,,related to,,BRENTUXIMAB VEDOTIN,,,,Hodgkins lymphoma,,,,, +21657994,666,,related to,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +21657993,667,,related to,,BRENTUXIMAB VEDOTIN,,,,primary cutaneous T-cell non-Hodgkin lymphoma,,,,, +22071488,668,,has part,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +21553377,669,,has part,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, +23435913,670,,affects,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, +20170701,671,,causes,,Tetracycline,,,,periodontitis,,,,, +19472933,672,,causes,,Tetracycline,,,,Helicobacter pylori infectious disease,,,,, +18080767,673,,affects,,Tetracycline,,,,periodontitis,,,,, +17969405,674,,affects,,Tetracycline,,,,bacterial infectious disease,,,,, +24565223,675,,prevents,,Tetracycline,,,,bacterial infectious disease,,,,, +10847016,676,,prevents,,Tetracycline,,,,inclusion conjunctivitis,,,,, +12376615,677,,related to,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +11754791,678,,related to,,(Alginate)n,,,,cystic fibrosis,,,,, +10599430,679,,related to,,(Alginate)n,,,,obesity disorder,,,,, +27435796,680,,affects,,(Alginate)n,,,,cystic fibrosis,,,,, +27132270,681,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +23415127,682,,affects,,(Alginate)n,,,,obesity disorder,,,,, +19854419,683,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +8246131,684,,disrupts,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +11492096,685,,prevents,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +23508922,686,,predisposes,,(Alginate)n,,,,obesity disorder,,,,, +11597598,687,,related to,,Zolimidine,,,,peptic ulcer disease,,,,, +20742970,688,,causes,,Chlorhexidine,,,,infectious disease,,,,, +16147932,689,,causes,,Chlorhexidine,,,,gingivitis,,,,, +15413413,690,,causes,,Chlorhexidine,,,,stomatitis,,,,, +13735208,691,,causes,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, +23793676,692,,affects,,Chlorhexidine,,,,Infection,,,,, +21319017,693,,affects,,Chlorhexidine,,,,pneumonia,,,,, +20585434,694,,affects,,Chlorhexidine,,,,stomatitis,,,,, +13503760,695,,affects,,Chlorhexidine,,,,periodontal disorder,,,,, +8506996,696,,affects,,Chlorhexidine,,,,gingivitis,,,,, +25489531,697,,disrupts,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, +22304373,698,,disrupts,,Chlorhexidine,,,,dental caries,,,,, +21939464,699,,disrupts,,Chlorhexidine,,,,Infection,,,,, +19793680,700,,disrupts,,Chlorhexidine,,,,bacterial infectious disease,,,,, +18040358,701,,disrupts,,Chlorhexidine,,,,infectious disease,,,,, +11272633,702,,disrupts,,Chlorhexidine,,,,gingivitis,,,,, +26042520,703,,prevents,,Chlorhexidine,,,,staphylococcal infection,,,,, +22617089,704,,prevents,,Chlorhexidine,,,,periodontitis,,,,, +22038778,705,,prevents,,Chlorhexidine,,,,bacterial infectious disease,,,,, +22000060,706,,prevents,,Chlorhexidine,,,,Infection,,,,, +21737487,707,,prevents,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, +19905103,708,,prevents,,Chlorhexidine,,,,periodontal disorder,,,,, +16765643,709,,prevents,,Chlorhexidine,,,,Neonatal sepsis,,,,, +14052320,710,,prevents,,Chlorhexidine,,,,pneumonia,,,,, +11830955,711,,prevents,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, +11145796,712,,prevents,,Chlorhexidine,,,,infectious disease,,,,, +10739867,713,,prevents,,Chlorhexidine,,,,stomatitis,,,,, +10141569,714,,prevents,,Chlorhexidine,,,,dental caries,,,,, +7990742,715,,prevents,,Chlorhexidine,,,,gingivitis,,,,, +23454202,716,,predisposes,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, +19942414,717,,predisposes,,Chlorhexidine,,,,periodontal disorder,,,,, +18735040,718,,predisposes,,Chlorhexidine,,,,dental caries,,,,, +16765642,719,,predisposes,,Chlorhexidine,,,,Neonatal sepsis,,,,, +24905090,720,,causes,,Nicergoline,,,,depressive disorder,,,,, +25103280,721,,related to,,RAMUCIRUMAB,,,,hepatocellular carcinoma,,,,, +22612331,722,,related to,,RAMUCIRUMAB,,,,neoplasm,,,,, +21600131,723,,related to,,RAMUCIRUMAB,,,,non-small cell lung carcinoma,,,,, +22008312,724,,affects,,RAMUCIRUMAB,,,,neoplasm,,,,, +23569571,725,,related to,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, +24533103,726,,disrupts,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, +21884997,727,,related to,,Thioctic acid,,,,cystinuria,,,,, +20207321,728,,related to,,Thioctic acid,,,,chronic progressive multiple sclerosis,,,,, +18115881,729,,related to,,Thioctic acid,,,,hypertensive disorder,,,,, +15406106,730,,related to,,Thioctic acid,,,,optic neuritis,,,,, +12204809,731,,related to,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, +11741203,732,,related to,,Thioctic acid,,,,multiple sclerosis,,,,, +11010945,733,,related to,,Thioctic acid,,,,AIDS,,,,, +10648973,734,,related to,,Thioctic acid,,,,skin disorder,,,,, +7603472,735,,related to,,Thioctic acid,,,,diabetic neuropathy,,,,, +16842192,736,,causes,,Thioctic acid,,,,hypertensive disorder,,,,, +21111426,737,,affects,,Thioctic acid,,,,optic neuritis,,,,, +18505755,738,,affects,,Thioctic acid,,,,diabetic neuropathy,,,,, +17198477,739,,affects,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, +12393284,740,,affects,,Thioctic acid,,,,Alzheimer disease,,,,, +9028391,741,,affects,,Thioctic acid,,,,hypertensive disorder,,,,, +21111429,742,,prevents,,Thioctic acid,,,,optic neuritis,,,,, +18775341,743,,prevents,,Thioctic acid,,,,skin disorder,,,,, +18076378,744,,prevents,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, +15377554,745,,prevents,,Thioctic acid,,,,stroke disorder,,,,, +13878249,746,,prevents,,Thioctic acid,,,,Alzheimer disease,,,,, +8826102,747,,prevents,,Thioctic acid,,,,hypertensive disorder,,,,, +8682086,748,,prevents,,Thioctic acid,,,,diabetic neuropathy,,,,, +15385084,749,,predisposes,,Thioctic acid,,,,Alzheimer disease,,,,, +26276598,750,,related to,,Ampicillin,,,,Sepsis,,,,, +19644222,751,,related to,,Ampicillin,,,,pneumonia,,,,, +27702232,752,,causes,,Ampicillin,,,,Sepsis,,,,, +15854005,753,,causes,,Ampicillin,,,,pneumonia,,,,, +14938843,754,,affects,,Ampicillin,,,,Sepsis,,,,, +8930713,755,,affects,,Ampicillin,,,,gonorrhea,,,,, +21012437,756,,disrupts,,Ampicillin,,,,gonorrhea,,,,, +24823382,757,,prevents,,Ampicillin,,,,Infection,,,,, +22838487,758,,prevents,,Ampicillin,,,,chorioamnionitis,,,,, +18801502,759,,prevents,,Ampicillin,,,,Sepsis,,,,, +17465667,760,,prevents,,Ampicillin,,,,pneumonia,,,,, +13675414,761,,predisposes,,Ampicillin,,,,Sepsis,,,,, +26048573,762,,causes,,Carbenicillin,,,,bacterial infectious disease,,,,, +19319362,763,,related to,,Benzoyl Peroxide,,,,acne,,,,, +10427135,764,,affects,,Benzoyl Peroxide,,,,acne,,,,, +7769964,765,,disrupts,,Benzoyl Peroxide,,,,acne,,,,, +12531968,766,,prevents,,Benzoyl Peroxide,,,,acne,,,,, +11597597,767,,related to,,Proglumide,,,,peptic ulcer disease,,,,, +18195146,768,,causes,,Pirenzepine,,,,peptic ulcer disease,,,,, +13022427,769,,affects,,Pirenzepine,,,,gastroesophageal reflux disease,,,,, +18547780,770,,prevents,,Pirenzepine,,,,peptic ulcer disease,,,,, +9345084,771,,related to,,Magnesium Oxide,,,,constipation disorder,,,,, +19628284,772,,disrupts,,Magnesium Oxide,,,,constipation disorder,,,,, +25714783,773,,prevents,,Ticarcillin,,,,Sepsis,,,,, +24735602,774,,related to,,Urea,,,,hepatocellular carcinoma,,,,, +18901918,775,,related to,,Urea,,,,radiodermatitis,,,,, +16423422,776,,related to,,Urea,,,,skin disorder,,,,, +16423421,777,,related to,,Urea,,,,psoriasis,,,,, +10983160,778,,related to,,Urea,,,,"dermatitis, atopic",,,,, +9883467,779,,related to,,Urea,,,,diabetes mellitus,,,,, +9435238,780,,related to,,Urea,,,,type 2 diabetes mellitus,,,,, +7778173,781,,related to,,Urea,,,,ornithine carbamoyltransferase deficiency,,,,, +17162115,782,,causes,,Urea,,,,diabetes mellitus,,,,, +16469778,783,,causes,,Urea,,,,type 2 diabetes mellitus,,,,, +18510405,784,,affects,,Urea,,,,hepatocellular carcinoma,,,,, +10531949,785,,affects,,Urea,,,,diabetes mellitus,,,,, +8735554,786,,affects,,Urea,,,,type 2 diabetes mellitus,,,,, +25972859,787,,produces,,Urea,,,,citrullinemia,,,,, +18901919,788,,prevents,,Urea,,,,radiodermatitis,,,,, +15303897,789,,prevents,,Urea,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +19154964,790,,predisposes,,Urea,,,,type 2 diabetes mellitus,,,,, +21175471,791,,related to,,Mannitol,,,,intracranial hypertension,,,,, +17706176,792,,related to,,Mannitol,,,,acute kidney failure,,,,, +17429747,793,,related to,,Mannitol,,,,stroke disorder,,,,, +15130853,794,,related to,,Mannitol,,,,brain cancer,,,,, +13201402,795,,related to,,Mannitol,,,,cystic fibrosis,,,,, +12470912,796,,related to,,Mannitol,,,,brain edema,,,,, +11875924,797,,related to,,Mannitol,,,,ciguatera fish poisoning,,,,, +10780851,798,,related to,,Mannitol,,,,brain injury,,,,, +8946483,799,,related to,,Mannitol,,,,bronchiectasis,,,,, +7891128,800,,related to,,Mannitol,,,,injury,,,,, +26278567,801,,causes,,Mannitol,,,,brain cancer,,,,, +25099324,802,,causes,,Mannitol,,,,hearing loss disorder,,,,, +21259902,803,,causes,,Mannitol,,,,brain injury,,,,, +18351985,804,,causes,,Mannitol,,,,hypotensive disorder,,,,, +15545947,805,,causes,,Mannitol,,,,brain edema,,,,, +12105301,806,,causes,,Mannitol,,,,intracranial hypertension,,,,, +11383337,807,,causes,,Mannitol,,,,injury,,,,, +9825580,808,,causes,,Mannitol,,,,acute kidney failure,,,,, +22439282,809,,affects,,Mannitol,,,,acute kidney failure,,,,, +18431992,810,,affects,,Mannitol,,,,hypotensive disorder,,,,, +10780860,811,,affects,,Mannitol,,,,brain injury,,,,, +10701562,812,,affects,,Mannitol,,,,injury,,,,, +10686125,813,,affects,,Mannitol,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +9315186,814,,affects,,Mannitol,,,,intracranial hypertension,,,,, +7084537,815,,affects,,Mannitol,,,,brain edema,,,,, +27493988,816,,disrupts,,Mannitol,,,,injury,,,,, +26052295,817,,disrupts,,Mannitol,,,,brain edema,,,,, +18331127,818,,prevents,,Mannitol,,,,Pain,,,,, +17838550,819,,prevents,,Mannitol,,,,brain injury,,,,, +9550870,820,,prevents,,Mannitol,,,,acute kidney failure,,,,, +8530867,821,,prevents,,Mannitol,,,,brain edema,,,,, +7816754,822,,prevents,,Mannitol,,,,intracranial hypertension,,,,, +21038220,823,,exacerbates,,Mannitol,,,,intracranial hypertension,,,,, +23554906,824,,predisposes,,Mannitol,,,,brain injury,,,,, +23171283,825,,predisposes,,Mannitol,,,,acute kidney failure,,,,, +15337034,826,,predisposes,,Mannitol,,,,brain edema,,,,, +9368450,827,,predisposes,,Mannitol,,,,injury,,,,, +25560945,828,,affects,,Artesunic acid,,,,neoplasm,,,,, +20380317,829,,affects,,Artesunic acid,,,,neoplasm,,,,, +17022154,830,,affects,,Artesunic acid,,,,cytomegalovirus infection,,,,, +15447136,831,,affects,,Artesunic acid,,,,malaria,,,,, +14695052,832,,affects,,Artesunic acid,,,,Fever,,,,, +9350747,833,,affects,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, +19053159,834,,disrupts,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, +17269195,835,,disrupts,,Artesunic acid,,,,neoplasm,,,,, +16806460,836,,disrupts,,Artesunic acid,,,,malaria,,,,, +10013375,837,,prevents,,Artesunic acid,,,,schistosomiasis,,,,, +8540473,838,,prevents,,Artesunic acid,,,,malaria,,,,, +16567243,839,,predisposes,,Artesunic acid,,,,malaria,,,,, +27639365,840,,affects,,Artemether,,,,Fever,,,,, +25565511,841,,affects,,Artemether,,,,malaria,,,,, +19253720,842,,prevents,,Artemether,,,,malaria,,,,, +10002115,843,,prevents,,Artemether,,,,urinary schistosomiasis,,,,, +8716445,844,,causes,,Isoproterenol,,,,atrial fibrillation,,,,, +25912644,845,,affects,,Isoproterenol,,,,obstructive lung disease,,,,, +24900253,846,,affects,,Isoproterenol,,,,obesity disorder,,,,, +9298156,847,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, +7542857,848,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, +26721271,849,,disrupts,,Isoproterenol,,,,obesity disorder,,,,, +7635739,850,,predisposes,,Isoproterenol,,,,atrial fibrillation,,,,, +23874783,851,,related to,,Bacitracin A,,,,pneumonia,,,,, +26428368,852,,prevents,,Bacitracin A,,,,bacterial infectious disease,,,,, +18829774,853,,prevents,,Bacitracin A,,,,cardiac rhythm disease,,,,, +16650012,854,,subclass of,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, +26133976,855,,causes,,Diflunisal,,,,Pain,,,,, +26132411,856,,affects,,Diflunisal,,,,Pain,,,,, +26009871,857,,affects,,Diflunisal,,,,Fever,,,,, +26009870,858,,affects,,Diflunisal,,,,Fever,,,,, +13234484,859,,affects,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, +14757294,860,,prevents,,Diflunisal,,,,Pain,,,,, +17020332,861,,causes,,Salsalate,,,,Insulin resistance,,,,, +21902985,862,,affects,,Salsalate,,,,diabetes mellitus,,,,, +25541729,863,,disrupts,,Salsalate,,,,Insulin resistance,,,,, +19533984,864,,prevents,,Salsalate,,,,diabetes mellitus,,,,, +26431050,865,,causes,,Sodium salicylate,,,,Fever,,,,, +11882723,866,,affects,,Sodium salicylate,,,,Fever,,,,, +9968696,867,,affects,,Sodium salicylate,,,,Fever,,,,, +15893532,868,,predisposes,,Sodium salicylate,,,,Pain,,,,, +7201382,869,,subclass of,,Aspirin,,,,Salicylic Acid,,,,, +26818861,870,,related to,,Aspirin,,,,myocardial infarction,,,,, +26532873,871,,related to,,Aspirin,,,,classic familial adenomatous polyposis,,,,, +26329928,872,,related to,,Aspirin,,,,type 2 diabetes mellitus,,,,, +26168722,873,,related to,,Aspirin,,,,Inflammation,,,,, +24076103,874,,related to,,Aspirin,,,,Hemorrhage,,,,, +20241570,875,,related to,,Aspirin,,,,Pain,,,,, +18524506,876,,related to,,Aspirin,,,,cataract,,,,, +18008074,877,,related to,,Aspirin,,,,diabetes mellitus,,,,, +17483160,878,,related to,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, +16078277,879,,related to,,Aspirin,,,,preeclampsia,,,,, +15283505,880,,related to,,Aspirin,,,,thrombotic disease,,,,, +13829413,881,,related to,,Aspirin,,,,retinal vein occlusion,,,,, +13174915,882,,related to,,Aspirin,,,,ST-elevation myocardial infarction,,,,, +12865539,883,,related to,,Aspirin,,,,cardiovascular disorder,,,,, +12749655,884,,related to,,Aspirin,,,,Salicylic Acid,,,,, +12502970,885,,related to,,Aspirin,,,,coronary artery disorder,,,,, +10635434,886,,related to,,Aspirin,,,,rheumatic heart disease,,,,, +10534181,887,,related to,,Aspirin,,,,osteoarthritis,,,,, +10473195,888,,related to,,Aspirin,,,,asthma,,,,, +9315521,889,,related to,,Aspirin,,,,atrial fibrillation,,,,, +8718389,890,,related to,,Aspirin,,,,stroke disorder,,,,, +8430499,891,,related to,,Aspirin,,,,Ischemic stroke,,,,, +7718877,892,,related to,,Aspirin,,,,acute coronary syndrome,,,,, +8745735,893,,related to,,Aspirin,,,,Salicylic Acid,,,,, +12749656,894,,close match,,Aspirin,,,,Salicylic Acid,,,,, +8745736,895,,close match,,Aspirin,,,,Salicylic Acid,,,,, +10716638,896,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, +10182446,897,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, +8959647,898,,derives from,,Aspirin,,,,Salicylic Acid,,,,, +7421635,899,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, +9047883,900,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, +27550629,901,,causes,,Aspirin,,,,transient ischemic attack,,,,, +27093984,902,,causes,,Aspirin,,,,Sepsis,,,,, +26941889,903,,causes,,Aspirin,,,,colonic neoplasm,,,,, +26621273,904,,causes,,Aspirin,,,,diabetic retinopathy,,,,, +25682183,905,,causes,,Aspirin,,,,Toothache,,,,, +24276147,906,,causes,,Aspirin,,,,osteoarthritis,,,,, +23603605,907,,causes,,Aspirin,,,,infertility disorder,,,,, +22149437,908,,causes,,Aspirin,,,,myocardial infarction,,,,, +21269587,909,,causes,,Aspirin,,,,preeclampsia,,,,, +21190178,910,,causes,,Aspirin,,,,Varicose Ulcer,,,,, +20967677,911,,causes,,Aspirin,,,,cerebral infarction,,,,, +20453125,912,,causes,,Aspirin,,,,squamous cell carcinoma,,,,, +20257764,913,,causes,,Aspirin,,,,vascular disorder,,,,, +18467493,914,,causes,,Aspirin,,,,periodontitis,,,,, +18133593,915,,causes,,Aspirin,,,,acute lung injury,,,,, +17905974,916,,causes,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, +16266546,917,,causes,,Aspirin,,,,cardiovascular disorder,,,,, +15908394,918,,causes,,Aspirin,,,,arthritic joint disease,,,,, +15782733,919,,causes,,Aspirin,,,,ulcerative colitis,,,,, +15251529,920,,causes,,Aspirin,,,,myocardial ischemia,,,,, +15022291,921,,causes,,Aspirin,,,,pneumonia,,,,, +14953515,922,,causes,,Aspirin,,,,diabetes mellitus,,,,, +14693157,923,,causes,,Aspirin,,,,atrial fibrillation,,,,, +14660024,924,,causes,,Aspirin,,,,ischemic disease,,,,, +14296178,925,,causes,,Aspirin,,,,type 2 diabetes mellitus,,,,, +13914591,926,,causes,,Aspirin,,,,digestive system disorder,,,,, +13814866,927,,causes,,Aspirin,,,,Fever,,,,, +13639281,928,,causes,,Aspirin,,,,acute coronary syndrome,,,,, +13639280,929,,causes,,Aspirin,,,,Ischemic stroke,,,,, +13405854,930,,causes,,Aspirin,,,,hypertensive disorder,,,,, +13278968,931,,causes,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, +11251562,932,,causes,,Aspirin,,,,Pain,,,,, +10850020,933,,causes,,Aspirin,,,,migraine disorder,,,,, +10555051,934,,causes,,Aspirin,,,,duodenal ulcer,,,,, +9350599,935,,causes,,Aspirin,,,,active peptic ulcer disease,,,,, +9238263,936,,causes,,Aspirin,,,,blood coagulation disease,,,,, +8683872,937,,causes,,Aspirin,,,,stroke disorder,,,,, +8518235,938,,causes,,Aspirin,,,,peptic ulcer disease,,,,, +8466167,939,,causes,,Aspirin,,,,Headache,,,,, +8232293,940,,causes,,Aspirin,,,,Hemorrhage,,,,, +7594346,941,,causes,,Aspirin,,,,asthma,,,,, +7353622,942,,causes,,Aspirin,,,,gastric ulcer,,,,, +7227553,943,,causes,,Aspirin,,,,injury,,,,, +26773149,944,,affects,,Aspirin,,,,atrial fibrillation,,,,, +26425353,945,,affects,,Aspirin,,,,atherosclerosis,,,,, +26396469,946,,affects,,Aspirin,,,,Dysmenorrhea,,,,, +25760183,947,,affects,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +24559876,948,,affects,,Aspirin,,,,coronary artery disorder,,,,, +23119254,949,,affects,,Aspirin,,,,brain aneurysm,,,,, +21758599,950,,affects,,Aspirin,,,,brain aneurysm,,,,, +21116359,951,,affects,,Aspirin,,,,major depressive disorder,,,,, +21116358,952,,affects,,Aspirin,,,,schizophrenia,,,,, +21031382,953,,affects,,Aspirin,,,,neoplasm,,,,, +20857373,954,,affects,,Aspirin,,,,melanoma,,,,, +20741170,955,,affects,,Aspirin,,,,fetal growth restriction,,,,, +20453126,956,,affects,,Aspirin,,,,squamous cell carcinoma,,,,, +19190473,957,,affects,,Aspirin,,,,acute lung injury,,,,, +18874269,958,,affects,,Aspirin,,,,preeclampsia,,,,, +18830463,959,,affects,,Aspirin,,,,Varicose Ulcer,,,,, +18706529,960,,affects,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, +18617993,961,,affects,,Aspirin,,,,Sepsis,,,,, +18348076,962,,affects,,Aspirin,,,,Headache,,,,, +18344374,963,,affects,,Aspirin,,,,bone fracture,,,,, +18277701,964,,affects,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, +18092588,965,,affects,,Aspirin,,,,Fever,,,,, +17810437,966,,affects,,Aspirin,,,,migraine disorder,,,,, +16655533,967,,affects,,Aspirin,,,,stroke disorder,,,,, +16466986,968,,affects,,Aspirin,,,,myocardial ischemia,,,,, +16123563,969,,affects,,Aspirin,,,,digestive system disorder,,,,, +15829936,970,,affects,,Aspirin,,,,hypertriglyceridemia,,,,, +15667690,971,,affects,,Aspirin,,,,hepatocellular carcinoma,,,,, +15311732,972,,affects,,Aspirin,,,,periodontitis,,,,, +15094783,973,,affects,,Aspirin,,,,diabetic retinopathy,,,,, +13831910,974,,affects,,Aspirin,,,,gastric ulcer,,,,, +13734334,975,,affects,,Aspirin,,,,Pregnancy,,,,, +13647977,976,,affects,,Aspirin,,,,neoplasm,,,,, +13624111,977,,affects,,Aspirin,,,,pneumonia,,,,, +13559011,978,,affects,,Aspirin,,,,type 2 diabetes mellitus,,,,, +13493823,979,,affects,,Aspirin,,,,thrombotic disease,,,,, +12884495,980,,affects,,Aspirin,,,,duodenal ulcer,,,,, +12815469,981,,affects,,Aspirin,,,,atherosclerosis,,,,, +12769418,982,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, +12607959,983,,affects,,Aspirin,,,,plasma cell myeloma,,,,, +12446363,984,,affects,,Aspirin,,,,hypertensive disorder,,,,, +12124867,985,,affects,,Aspirin,,,,heart disorder,,,,, +11661767,986,,affects,,Aspirin,,,,peptic ulcer disease,,,,, +11474111,987,,affects,,Aspirin,,,,diabetes mellitus,,,,, +11357781,988,,affects,,Aspirin,,,,ischemic disease,,,,, +11341534,989,,affects,,Aspirin,,,,ulcer disease,,,,, +11135514,990,,affects,,Aspirin,,,,cerebrovascular disorder,,,,, +10875862,991,,affects,,Aspirin,,,,acquired polycythemia vera,,,,, +10830878,992,,affects,,Aspirin,,,,Inflammation,,,,, +10337669,993,,affects,,Aspirin,,,,colorectal neoplasm,,,,, +10331252,994,,affects,,Aspirin,,,,peptic ulcer disease,,,,, +10226347,995,,affects,,Aspirin,,,,thrombophilia,,,,, +10082315,996,,affects,,Aspirin,,,,Pain,,,,, +10068618,997,,affects,,Aspirin,,,,adenoma,,,,, +9766251,998,,affects,,Aspirin,,,,injury,,,,, +9581221,999,,affects,,Aspirin,,,,cataract,,,,, +9528323,1000,,affects,,Aspirin,,,,asthma,,,,, +9510044,1001,,affects,,Aspirin,,,,transient ischemic attack,,,,, +9342553,1002,,affects,,Aspirin,,,,Salicylic Acid,,,,, +9259288,1003,,affects,,Aspirin,,,,Fever,,,,, +9203900,1004,,affects,,Aspirin,,,,Hypercholesterolemia,,,,, +9160463,1005,,affects,,Aspirin,,,,gastric ulcer,,,,, +9084341,1006,,affects,,Aspirin,,,,Ischemic stroke,,,,, +8650258,1007,,affects,,Aspirin,,,,Hemorrhage,,,,, +8543326,1008,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, +8290962,1009,,affects,,Aspirin,,,,ulcer disease,,,,, +8187935,1010,,affects,,Aspirin,,,,injury,,,,, +8173134,1011,,affects,,Aspirin,,,,thrombotic disease,,,,, +8169760,1012,,affects,,Aspirin,,,,preeclampsia,,,,, +7935107,1013,,affects,,Aspirin,,,,prostate cancer,,,,, +7920712,1014,,affects,,Aspirin,,,,Hemorrhage,,,,, +7876600,1015,,affects,,Aspirin,,,,Hemorrhage,,,,, +7820545,1016,,affects,,Aspirin,,,,vascular disorder,,,,, +7816175,1017,,affects,,Aspirin,,,,Pregnancy,,,,, +7635677,1018,,affects,,Aspirin,,,,myocardial ischemia,,,,, +7478885,1019,,affects,,Aspirin,,,,coronary artery disorder,,,,, +7468514,1020,,affects,,Aspirin,,,,stroke disorder,,,,, +7251569,1021,,affects,,Aspirin,,,,myocardial infarction,,,,, +7213554,1022,,affects,,Aspirin,,,,cardiovascular disorder,,,,, +7156429,1023,,affects,,Aspirin,,,,Inflammation,,,,, +14159165,1024,,affects,,Aspirin,,,,Salicylic Acid,,,,, +27335099,1025,,disrupts,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +24958273,1026,,disrupts,,Aspirin,,,,Fever,,,,, +24520178,1027,,disrupts,,Aspirin,,,,melanoma,,,,, +24047967,1028,,disrupts,,Aspirin,,,,cardiovascular disorder,,,,, +22107293,1029,,disrupts,,Aspirin,,,,atrial fibrillation,,,,, +22100738,1030,,disrupts,,Aspirin,,,,fetal growth restriction,,,,, +22027792,1031,,disrupts,,Aspirin,,,,venous thromboembolism,,,,, +21434441,1032,,disrupts,,Aspirin,,,,thrombophilia,,,,, +20385507,1033,,disrupts,,Aspirin,,,,essential thrombocythemia,,,,, +19437129,1034,,disrupts,,Aspirin,,,,Sepsis,,,,, +19421638,1035,,disrupts,,Aspirin,,,,pneumonia,,,,, +19318532,1036,,disrupts,,Aspirin,,,,vascular disorder,,,,, +18604728,1037,,disrupts,,Aspirin,,,,type 2 diabetes mellitus,,,,, +18599969,1038,,disrupts,,Aspirin,,,,arthritic joint disease,,,,, +18445880,1039,,disrupts,,Aspirin,,,,ovarian cancer,,,,, +18225861,1040,,disrupts,,Aspirin,,,,Hemorrhage,,,,, +18203584,1041,,disrupts,,Aspirin,,,,brain aneurysm,,,,, +17476286,1042,,disrupts,,Aspirin,,,,Fatigue,,,,, +17225706,1043,,disrupts,,Aspirin,,,,transient ischemic attack,,,,, +16676314,1044,,disrupts,,Aspirin,,,,ulcer disease,,,,, +16484307,1045,,disrupts,,Aspirin,,,,acute lung injury,,,,, +14296080,1046,,disrupts,,Aspirin,,,,Pregnancy,,,,, +14068900,1047,,disrupts,,Aspirin,,,,active peptic ulcer disease,,,,, +13892678,1048,,disrupts,,Aspirin,,,,breast neoplasm,,,,, +13449558,1049,,disrupts,,Aspirin,,,,colorectal neoplasm,,,,, +12947740,1050,,disrupts,,Aspirin,,,,diabetic retinopathy,,,,, +12815470,1051,,disrupts,,Aspirin,,,,atherosclerosis,,,,, +12714476,1052,,disrupts,,Aspirin,,,,cataract,,,,, +12478523,1053,,disrupts,,Aspirin,,,,preeclampsia,,,,, +12450426,1054,,disrupts,,Aspirin,,,,Barrett esophagus,,,,, +12023670,1055,,disrupts,,Aspirin,,,,hypertensive disorder,,,,, +11827133,1056,,disrupts,,Aspirin,,,,diabetes mellitus,,,,, +10318928,1057,,disrupts,,Aspirin,,,,Myalgia,,,,, +9742254,1058,,disrupts,,Aspirin,,,,adenoma,,,,, +9148614,1059,,disrupts,,Aspirin,,,,neoplasm,,,,, +8526818,1060,,disrupts,,Aspirin,,,,myocardial infarction,,,,, +7995298,1061,,disrupts,,Aspirin,,,,Inflammation,,,,, +7878103,1062,,disrupts,,Aspirin,,,,prostate cancer,,,,, +7775480,1063,,disrupts,,Aspirin,,,,Pain,,,,, +7723340,1064,,disrupts,,Aspirin,,,,stroke disorder,,,,, +7712646,1065,,disrupts,,Aspirin,,,,coronary artery disorder,,,,, +7261879,1066,,disrupts,,Aspirin,,,,thrombotic disease,,,,, +24597938,1067,,prevents,,Aspirin,,,,thrombophilia,,,,, +24091248,1068,,prevents,,Aspirin,,,,disseminated intravascular coagulation,,,,, +24015329,1069,,prevents,,Aspirin,,,,neoplasm of esophagus,,,,, +23042755,1070,,prevents,,Aspirin,,,,brain aneurysm,,,,, +22291835,1071,,prevents,,Aspirin,,,,Hemorrhage,,,,, +21962376,1072,,prevents,,Aspirin,,,,venous thromboembolism,,,,, +21587985,1073,,prevents,,Aspirin,,,,blood coagulation disease,,,,, +21116357,1074,,prevents,,Aspirin,,,,schizophrenia,,,,, +20356983,1075,,prevents,,Aspirin,,,,acute lung injury,,,,, +20189716,1076,,prevents,,Aspirin,,,,brain infarction,,,,, +18414184,1077,,prevents,,Aspirin,,,,multiple sclerosis,,,,, +18344373,1078,,prevents,,Aspirin,,,,bone fracture,,,,, +17911903,1079,,prevents,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, +17240995,1080,,prevents,,Aspirin,,,,hepatocellular carcinoma,,,,, +16163718,1081,,prevents,,Aspirin,,,,Sepsis,,,,, +15608454,1082,,prevents,,Aspirin,,,,squamous cell carcinoma,,,,, +14796348,1083,,prevents,,Aspirin,,,,arthritic joint disease,,,,, +14183452,1084,,prevents,,Aspirin,,,,pneumonia,,,,, +13992680,1085,,prevents,,Aspirin,,,,diabetes mellitus,,,,, +13992679,1086,,prevents,,Aspirin,,,,type 2 diabetes mellitus,,,,, +13770407,1087,,prevents,,Aspirin,,,,diabetic retinopathy,,,,, +13624060,1088,,prevents,,Aspirin,,,,injury,,,,, +13536062,1089,,prevents,,Aspirin,,,,non-small cell lung carcinoma,,,,, +13041448,1090,,prevents,,Aspirin,,,,atrial fibrillation,,,,, +12791249,1091,,prevents,,Aspirin,,,,asthma,,,,, +12594676,1092,,prevents,,Aspirin,,,,Fatigue,,,,, +12361944,1093,,prevents,,Aspirin,,,,active peptic ulcer disease,,,,, +12273189,1094,,prevents,,Aspirin,,,,Myalgia,,,,, +11593026,1095,,prevents,,Aspirin,,,,colorectal neoplasm,,,,, +11289178,1096,,prevents,,Aspirin,,,,migraine disorder,,,,, +11042545,1097,,prevents,,Aspirin,,,,Barrett esophagus,,,,, +10366572,1098,,prevents,,Aspirin,,,,cerebrovascular disorder,,,,, +10293726,1099,,prevents,,Aspirin,,,,prostate cancer,,,,, +10185706,1100,,prevents,,Aspirin,,,,colonic neoplasm,,,,, +10099399,1101,,prevents,,Aspirin,,,,atherosclerosis,,,,, +10096705,1102,,prevents,,Aspirin,,,,cerebral infarction,,,,, +10004143,1103,,prevents,,Aspirin,,,,blindness (disorder),,,,, +9665356,1104,,prevents,,Aspirin,,,,hypertensive disorder,,,,, +9388878,1105,,prevents,,Aspirin,,,,coronary artery disorder,,,,, +9150304,1106,,prevents,,Aspirin,,,,habitual spontaneous abortion,,,,, +8853513,1107,,prevents,,Aspirin,,,,gastric ulcer,,,,, +8755758,1108,,prevents,,Aspirin,,,,vascular disorder,,,,, +8494726,1109,,prevents,,Aspirin,,,,ulcer disease,,,,, +8347839,1110,,prevents,,Aspirin,,,,peptic ulcer disease,,,,, +8325441,1111,,prevents,,Aspirin,,,,ischemic disease,,,,, +7877588,1112,,prevents,,Aspirin,,,,cardiovascular disorder,,,,, +7852267,1113,,prevents,,Aspirin,,,,Headache,,,,, +7716613,1114,,prevents,,Aspirin,,,,neoplasm,,,,, +7603499,1115,,prevents,,Aspirin,,,,myocardial ischemia,,,,, +7487700,1116,,prevents,,Aspirin,,,,Inflammation,,,,, +7457050,1117,,prevents,,Aspirin,,,,peripheral vascular disease,,,,, +7455467,1118,,prevents,,Aspirin,,,,Ischemic stroke,,,,, +7455466,1119,,prevents,,Aspirin,,,,stroke disorder,,,,, +7455465,1120,,prevents,,Aspirin,,,,transient ischemic attack,,,,, +7419265,1121,,prevents,,Aspirin,,,,heart disorder,,,,, +7368248,1122,,prevents,,Aspirin,,,,thrombotic disease,,,,, +7317027,1123,,prevents,,Aspirin,,,,preeclampsia,,,,, +7275741,1124,,prevents,,Aspirin,,,,acute coronary syndrome,,,,, +7264064,1125,,prevents,,Aspirin,,,,Pain,,,,, +7196018,1126,,prevents,,Aspirin,,,,myocardial infarction,,,,, +7159192,1127,,prevents,,Aspirin,,,,fetal growth restriction,,,,, +7110859,1128,,prevents,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +22126985,1129,,exacerbates,,Aspirin,,,,gastric ulcer,,,,, +21411566,1130,,exacerbates,,Aspirin,,,,macular degeneration,,,,, +21359197,1131,,exacerbates,,Aspirin,,,,acute coronary syndrome,,,,, +26115547,1132,,predisposes,,Aspirin,,,,cerebral infarction,,,,, +25254777,1133,,predisposes,,Aspirin,,,,essential thrombocythemia,,,,, +23315977,1134,,predisposes,,Aspirin,,,,brain aneurysm,,,,, +21525767,1135,,predisposes,,Aspirin,,,,Fever,,,,, +21487721,1136,,predisposes,,Aspirin,,,,Hemorrhage,,,,, +20679052,1137,,predisposes,,Aspirin,,,,blood coagulation disease,,,,, +20234206,1138,,predisposes,,Aspirin,,,,hepatocellular carcinoma,,,,, +20155873,1139,,predisposes,,Aspirin,,,,placental insufficiency,,,,, +19346376,1140,,predisposes,,Aspirin,,,,chronic renal failure syndrome,,,,, +18235965,1141,,predisposes,,Aspirin,,,,macular degeneration,,,,, +17872103,1142,,predisposes,,Aspirin,,,,atrial fibrillation,,,,, +17123250,1143,,predisposes,,Aspirin,,,,acute coronary syndrome,,,,, +16813141,1144,,predisposes,,Aspirin,,,,melanoma,,,,, +16162173,1145,,predisposes,,Aspirin,,,,ulcerative colitis,,,,, +15461534,1146,,predisposes,,Aspirin,,,,gastric ulcer,,,,, +14856258,1147,,predisposes,,Aspirin,,,,neoplasm of esophagus,,,,, +14426809,1148,,predisposes,,Aspirin,,,,neoplasm,,,,, +14234947,1149,,predisposes,,Aspirin,,,,diabetes mellitus,,,,, +14126301,1150,,predisposes,,Aspirin,,,,cerebrovascular disorder,,,,, +14052964,1151,,predisposes,,Aspirin,,,,Inflammation,,,,, +14015029,1152,,predisposes,,Aspirin,,,,transient ischemic attack,,,,, +13644771,1153,,predisposes,,Aspirin,,,,asthma,,,,, +13536064,1154,,predisposes,,Aspirin,,,,non-small cell lung carcinoma,,,,, +13299957,1155,,predisposes,,Aspirin,,,,ovarian cancer,,,,, +12673405,1156,,predisposes,,Aspirin,,,,bone fracture,,,,, +12382415,1157,,predisposes,,Aspirin,,,,colorectal neoplasm,,,,, +11071059,1158,,predisposes,,Aspirin,,,,injury,,,,, +10962122,1159,,predisposes,,Aspirin,,,,ischemic disease,,,,, +10547299,1160,,predisposes,,Aspirin,,,,coronary artery disorder,,,,, +10337650,1161,,predisposes,,Aspirin,,,,adenoma,,,,, +9857077,1162,,predisposes,,Aspirin,,,,vascular disorder,,,,, +9535755,1163,,predisposes,,Aspirin,,,,thrombotic disease,,,,, +9535754,1164,,predisposes,,Aspirin,,,,hypertensive disorder,,,,, +9491661,1165,,predisposes,,Aspirin,,,,cardiovascular disorder,,,,, +9477464,1166,,predisposes,,Aspirin,,,,prostate cancer,,,,, +9404829,1167,,predisposes,,Aspirin,,,,ulcer disease,,,,, +8850172,1168,,predisposes,,Aspirin,,,,myocardial ischemia,,,,, +8763743,1169,,predisposes,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +8545255,1170,,predisposes,,Aspirin,,,,Ischemic stroke,,,,, +7865543,1171,,predisposes,,Aspirin,,,,Headache,,,,, +7858710,1172,,predisposes,,Aspirin,,,,myocardial infarction,,,,, +7667039,1173,,predisposes,,Aspirin,,,,preeclampsia,,,,, +7659453,1174,,predisposes,,Aspirin,,,,stroke disorder,,,,, +7653535,1175,,predisposes,,Aspirin,,,,peptic ulcer disease,,,,, +7596288,1176,,predisposes,,Aspirin,,,,atherosclerosis,,,,, +7078619,1177,,predisposes,,Aspirin,,,,active peptic ulcer disease,,,,, +23297288,1178,,prevents,,Vemurafenib,,,,neoplasm,,,,, +22851133,1179,,related to,,Dabrafenib,,,,melanoma,,,,, +18622575,1180,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +18622575,1181,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +26359747,1182,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +26359747,1183,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +24697302,1184,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +24697302,1185,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +10513644,1186,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +10513644,1187,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +15306394,1188,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +15306394,1189,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +10518221,1190,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +9906740,1191,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +8278260,1192,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +9085295,1193,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +25915149,1194,,related to,,Sodium monofluorophosphate,,,,dental caries,,,,, +25861359,1195,,disrupts,,Sodium monofluorophosphate,,,,allergic disease,,,,, +19241020,1196,,related to,,Sodium Fluoride,,,,gingivitis,,,,, +17448182,1197,,related to,,Sodium Fluoride,,,,aortic valve stenosis,,,,, +9111981,1198,,related to,,Sodium Fluoride,,,,dental caries,,,,, +25583763,1199,,causes,,Sodium Fluoride,,,,dental fluorosis,,,,, +23780312,1200,,affects,,Sodium Fluoride,,,,dental caries,,,,, +18846793,1201,,affects,,Sodium Fluoride,,,,allergic disease,,,,, +25986070,1202,,disrupts,,Sodium Fluoride,,,,allergic disease,,,,, +14286543,1203,,prevents,,Sodium Fluoride,,,,gingivitis,,,,, +10538561,1204,,prevents,,Sodium Fluoride,,,,periodontal disorder,,,,, +10425615,1205,,prevents,,Sodium Fluoride,,,,dental caries,,,,, +19971424,1206,,related to,,Rifaximin,,,,irritable bowel syndrome,,,,, +17053293,1207,,related to,,Rifaximin,,,,hepatic encephalopathy,,,,, +18714048,1208,,causes,,Rifaximin,,,,irritable bowel syndrome,,,,, +8925773,1209,,causes,,Rifaximin,,,,diarrheal disease,,,,, +25434952,1210,,affects,,Rifaximin,,,,alcoholic hepatitis,,,,, +24257624,1211,,affects,,Rifaximin,,,,Infection,,,,, +20149851,1212,,affects,,Rifaximin,,,,Crohn disease,,,,, +19665399,1213,,affects,,Rifaximin,,,,diverticulitis,,,,, +18685028,1214,,affects,,Rifaximin,,,,irritable bowel syndrome,,,,, +16575444,1215,,affects,,Rifaximin,,,,hepatic encephalopathy,,,,, +21278571,1216,,prevents,,Rifaximin,,,,alcoholic hepatitis,,,,, +16143515,1217,,prevents,,Rifaximin,,,,diverticulitis,,,,, +15134586,1218,,prevents,,Rifaximin,,,,hepatic encephalopathy,,,,, +11830138,1219,,prevents,,Rifaximin,,,,irritable bowel syndrome,,,,, +11830137,1220,,prevents,,Rifaximin,,,,diarrheal disease,,,,, +15717459,1221,,predisposes,,Rifaximin,,,,hepatic encephalopathy,,,,, +25706307,1222,,related to,,Glycine,,,,cystic fibrosis,,,,, +20102524,1223,,related to,,Glycine,,,,psychotic disorder,,,,, +17514096,1224,,related to,,Glycine,,,,hypertensive disorder,,,,, +13080824,1225,,related to,,Glycine,,,,Alzheimer disease,,,,, +12589996,1226,,related to,,Glycine,,,,nutritional disorder,,,,, +7298031,1227,,related to,,Glycine,,,,schizophrenia,,,,, +17397486,1228,,causes,,Glycine,,,,Cognitive impairment,,,,, +17125423,1229,,affects,,Glycine,,,,asthma,,,,, +7530162,1230,,affects,,Glycine,,,,schizophrenia,,,,, +12589998,1231,,produces,,Glycine,,,,nutritional disorder,,,,, +16845009,1232,,disrupts,,Glycine,,,,Alzheimer disease,,,,, +12278394,1233,,prevents,,Glycine,,,,hypertensive disorder,,,,, +15546112,1234,,predisposes,,Glycine,,,,asthma,,,,, +16711324,1235,,related to,,Sorbitol,,,,injury,,,,, +10684679,1236,,related to,,Sorbitol,,,,constipation disorder,,,,, +20821510,1237,,causes,,Sorbitol,,,,constipation disorder,,,,, +15564538,1238,,causes,,Sorbitol,,,,injury,,,,, +17658899,1239,,affects,,Sorbitol,,,,osteoarthritis,,,,, +26106951,1240,,prevents,,Sorbitol,,,,injury,,,,, +10478248,1241,,affects,,Foscarnet,,,,cytomegalovirus infection,,,,, +10481132,1242,,prevents,,Foscarnet,,,,cytomegalovirus infection,,,,, +22857734,1243,,prevents,,Atogepant,,,,migraine disorder,,,,, +25325960,1244,,prevents,,Rimegepant,,,,migraine disorder,,,,, +21939131,1245,,prevents,,Rimegepant,,,,Pain,,,,, +10553741,1246,,related to,,ATROPINE,,,,poisoning,,,,, +19468294,1247,,causes,,ATROPINE,,,,Pain,,,,, +18989245,1248,,causes,,ATROPINE,,,,digestive system disorder,,,,, +14576640,1249,,causes,,ATROPINE,,,,myopia,,,,, +10716177,1250,,causes,,ATROPINE,,,,Mydriasis,,,,, +10361041,1251,,causes,,ATROPINE,,,,amblyopia,,,,, +9746341,1252,,causes,,ATROPINE,,,,poisoning,,,,, +9301311,1253,,causes,,ATROPINE,,,,cardiac arrest,,,,, +8524259,1254,,causes,,ATROPINE,,,,Insulin resistance,,,,, +8480152,1255,,causes,,ATROPINE,,,,Bradycardia,,,,, +26343406,1256,,affects,,ATROPINE,,,,hypoglycemia,,,,, +23118209,1257,,affects,,ATROPINE,,,,Mydriasis,,,,, +19520979,1258,,affects,,ATROPINE,,,,hypoglycemia,,,,, +12406813,1259,,affects,,ATROPINE,,,,cardiac arrest,,,,, +11741867,1260,,affects,,ATROPINE,,,,Bradycardia,,,,, +10264479,1261,,affects,,ATROPINE,,,,Hemorrhage,,,,, +9293832,1262,,affects,,ATROPINE,,,,poisoning,,,,, +9041302,1263,,affects,,ATROPINE,,,,Bradycardia,,,,, +7845760,1264,,affects,,ATROPINE,,,,Bradycardia,,,,, +7111083,1265,,affects,,ATROPINE,,,,myopia,,,,, +26141463,1266,,disrupts,,ATROPINE,,,,hypoglycemia,,,,, +23143978,1267,,disrupts,,ATROPINE,,,,poisoning,,,,, +20133204,1268,,disrupts,,ATROPINE,,,,Pain,,,,, +18168420,1269,,disrupts,,ATROPINE,,,,Bradycardia,,,,, +7111084,1270,,disrupts,,ATROPINE,,,,myopia,,,,, +9676858,1271,,prevents,,ATROPINE,,,,poisoning,,,,, +9198373,1272,,prevents,,ATROPINE,,,,myopia,,,,, +8451883,1273,,prevents,,ATROPINE,,,,cardiac arrest,,,,, +23699298,1274,,predisposes,,ATROPINE,,,,myopia,,,,, +14640163,1275,,predisposes,,ATROPINE,,,,poisoning,,,,, +7953996,1276,,affects,,Tolcapone,,,,Parkinson disease,,,,, +15643297,1277,,related to,,Entacapone,,,,Parkinson disease,,,,, +10033650,1278,,causes,,Entacapone,,,,Parkinson disease,,,,, +15952178,1279,,affects,,Entacapone,,,,Parkinson disease,,,,, +20308336,1280,,disrupts,,Entacapone,,,,Parkinson disease,,,,, +25394620,1281,,affects,,Veliparib,,,,neoplasm,,,,, +21697473,1282,,affects,,Veliparib,,,,triple-negative breast carcinoma,,,,, +21882624,1283,,causes,,Talazoparib,,,,neoplasm,,,,, +22572154,1284,,affects,,Talazoparib,,,,neoplasm,,,,, +21697476,1285,,affects,,Talazoparib,,,,triple-negative breast carcinoma,,,,, +22916819,1286,,prevents,,Talazoparib,,,,neoplasm,,,,, +24451977,1287,,related to,,Olaparib,,,,triple-negative breast carcinoma,,,,, +25473017,1288,,causes,,Olaparib,,,,pancreatic ductal adenocarcinoma,,,,, +25473016,1289,,causes,,Olaparib,,,,non-small cell lung carcinoma,,,,, +22160122,1290,,causes,,Olaparib,,,,head and neck neoplasm,,,,, +24770500,1291,,affects,,Olaparib,,,,castration-resistant prostate carcinoma,,,,, +24672020,1292,,affects,,Olaparib,,,,prostate cancer,,,,, +22977330,1293,,affects,,Olaparib,,,,neoplasm,,,,, +21697474,1294,,affects,,Olaparib,,,,triple-negative breast carcinoma,,,,, +24201965,1295,,prevents,,Olaparib,,,,Neoplasm Metastasis,,,,, +27698235,1296,,related to,,Capsaicin,,,,arthritic joint disease,,,,, +22276323,1297,,related to,,Capsaicin,,,,herpes zoster,,,,, +13200623,1298,,related to,,Capsaicin,,,,migraine disorder,,,,, +11537529,1299,,related to,,Capsaicin,,,,Cough,,,,, +10028696,1300,,related to,,Capsaicin,,,,diabetic neuropathy,,,,, +8608120,1301,,related to,,Capsaicin,,,,osteoarthritis,,,,, +8470968,1302,,related to,,Capsaicin,,,,postherpetic neuralgia,,,,, +8246278,1303,,related to,,Capsaicin,,,,neuralgia,,,,, +7965643,1304,,related to,,Capsaicin,,,,Pruritus,,,,, +7239245,1305,,related to,,Capsaicin,,,,Pain,,,,, +26554289,1306,,causes,,Capsaicin,,,,stroke disorder,,,,, +24505933,1307,,causes,,Capsaicin,,,,Muscle spasm,,,,, +18391785,1308,,causes,,Capsaicin,,,,neuralgia,,,,, +16420383,1309,,causes,,Capsaicin,,,,migraine disorder,,,,, +11163813,1310,,causes,,Capsaicin,,,,arthritic joint disease,,,,, +9650510,1311,,causes,,Capsaicin,,,,Myalgia,,,,, +8975038,1312,,causes,,Capsaicin,,,,Vomiting,,,,, +8261437,1313,,causes,,Capsaicin,,,,Cough,,,,, +7430731,1314,,causes,,Capsaicin,,,,Pruritus,,,,, +7414435,1315,,causes,,Capsaicin,,,,Pain,,,,, +27524804,1316,,affects,,Capsaicin,,,,arthritic joint disease,,,,, +25438971,1317,,affects,,Capsaicin,,,,brain injury,,,,, +19404541,1318,,affects,,Capsaicin,,,,neuroma,,,,, +15791019,1319,,affects,,Capsaicin,,,,Pruritus,,,,, +10951234,1320,,affects,,Capsaicin,,,,stroke disorder,,,,, +10764355,1321,,affects,,Capsaicin,,,,Pain,,,,, +10290167,1322,,affects,,Capsaicin,,,,Pruritus,,,,, +10171204,1323,,affects,,Capsaicin,,,,neuralgia,,,,, +8975035,1324,,affects,,Capsaicin,,,,Vomiting,,,,, +8515286,1325,,affects,,Capsaicin,,,,Pain,,,,, +8515285,1326,,affects,,Capsaicin,,,,postherpetic neuralgia,,,,, +8441743,1327,,affects,,Capsaicin,,,,Cough,,,,, +7281158,1328,,affects,,Capsaicin,,,,Cough,,,,, +18283970,1329,,disrupts,,Capsaicin,,,,Pain,,,,, +17652809,1330,,disrupts,,Capsaicin,,,,arthritic joint disease,,,,, +14643733,1331,,disrupts,,Capsaicin,,,,breast neoplasm,,,,, +9869751,1332,,disrupts,,Capsaicin,,,,Cough,,,,, +8160008,1333,,disrupts,,Capsaicin,,,,Pruritus,,,,, +25438980,1334,,prevents,,Capsaicin,,,,brain injury,,,,, +20404597,1335,,prevents,,Capsaicin,,,,postherpetic neuralgia,,,,, +17168513,1336,,prevents,,Capsaicin,,,,migraine disorder,,,,, +16978917,1337,,prevents,,Capsaicin,,,,neuralgia,,,,, +15822967,1338,,prevents,,Capsaicin,,,,stroke disorder,,,,, +10290168,1339,,prevents,,Capsaicin,,,,Pruritus,,,,, +8608117,1340,,prevents,,Capsaicin,,,,osteoarthritis,,,,, +8246280,1341,,prevents,,Capsaicin,,,,Pain,,,,, +14706687,1342,,predisposes,,Capsaicin,,,,Pain,,,,, +24021484,1343,,causes,,Nusinersen,,,,spinal muscular atrophy,,,,, +22907909,1344,,affects,,Nusinersen,,,,spinal muscular atrophy,,,,, +27681284,1345,,related to,,Hyaluronic acid sodium salt,,,,alcoholic hepatitis,,,,, +26794689,1346,,related to,,Hyaluronic acid sodium salt,,,,carpal tunnel syndrome,,,,, +20903427,1347,,related to,,Hyaluronic acid sodium salt,,,,Skin ulcer,,,,, +18915649,1348,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +18915649,1349,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +15362486,1350,,related to,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, +14268478,1351,,related to,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, +9147590,1352,,related to,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, +7458117,1353,,related to,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +17074499,1354,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +17074499,1355,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +12401778,1356,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +12401778,1357,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +11319224,1358,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +11319224,1359,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +7287149,1360,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +7699622,1361,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +12146167,1362,,causes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +8938037,1363,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +8541022,1364,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +7683831,1365,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +7895314,1366,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +18839068,1367,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +18839068,1368,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +9813251,1369,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +9813251,1370,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +17165364,1371,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +17165364,1372,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +23839601,1373,,disrupts,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, +22764727,1374,,disrupts,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, +7155073,1375,,disrupts,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +18262848,1376,,prevents,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, +11511344,1377,,prevents,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +21264578,1378,,predisposes,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, +11605823,1379,,predisposes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +24659748,1380,,related to,,Zoledronic acid,,,,osteoporosis,,,,, +18902207,1381,,causes,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, +18856931,1382,,causes,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, +13083414,1383,,causes,,Zoledronic acid,,,,bone fracture,,,,, +21044659,1384,,affects,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, +19059032,1385,,affects,,Zoledronic acid,,,,bone osteosarcoma,,,,, +13892047,1386,,affects,,Zoledronic acid,,,,bone fracture,,,,, +13448998,1387,,affects,,Zoledronic acid,,,,osteonecrosis,,,,, +9617769,1388,,affects,,Zoledronic acid,,,,osteoporosis,,,,, +24472422,1389,,disrupts,,Zoledronic acid,,,,sarcoma,,,,, +20879055,1390,,disrupts,,Zoledronic acid,,,,Neoplasm Metastasis,,,,, +20879053,1391,,disrupts,,Zoledronic acid,,,,Pain,,,,, +13311906,1392,,disrupts,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, +9617771,1393,,disrupts,,Zoledronic acid,,,,bone fracture,,,,, +22662537,1394,,prevents,,Zoledronic acid,,,,osteoporosis,,,,, +20148397,1395,,prevents,,Zoledronic acid,,,,osteonecrosis,,,,, +13621414,1396,,prevents,,Zoledronic acid,,,,bone fracture,,,,, +12127006,1397,,prevents,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, +20851623,1398,,predisposes,,Zoledronic acid,,,,bone fracture,,,,, +15272127,1399,,predisposes,,Zoledronic acid,,,,osteonecrosis,,,,, +14006582,1400,,prevents,,Risedronic acid,,,,osteoporosis,,,,, +17290459,1401,,affects,,IBANDRONIC ACID,,,,osteonecrosis,,,,, +9797983,1402,,affects,,IBANDRONIC ACID,,,,Neoplasm Metastasis,,,,, +15290649,1403,,prevents,,IBANDRONIC ACID,,,,bone disorder,,,,, +13697992,1404,,prevents,,IBANDRONIC ACID,,,,Pain,,,,, +10307139,1405,,prevents,,IBANDRONIC ACID,,,,postmenopausal osteoporosis,,,,, +10028971,1406,,prevents,,IBANDRONIC ACID,,,,osteoporosis,,,,, +18363632,1407,,predisposes,,IBANDRONIC ACID,,,,Abdominal pain,,,,, +9434475,1408,,predisposes,,IBANDRONIC ACID,,,,osteoporosis,,,,, +17514758,1409,,related to,,Alendronic acid,,,,osteoarthritis,,,,, +14283477,1410,,related to,,Alendronic acid,,,,osteoporosis,,,,, +11575454,1411,,related to,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +14254304,1412,,causes,,Alendronic acid,,,,asthma,,,,, +14049757,1413,,causes,,Alendronic acid,,,,osteoporosis,,,,, +11710947,1414,,causes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +25124892,1415,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +24296937,1416,,affects,,Alendronic acid,,,,bone disorder,,,,, +17701514,1417,,affects,,Alendronic acid,,,,osteoarthritis,,,,, +14769549,1418,,affects,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +12316243,1419,,affects,,Alendronic acid,,,,osteoporosis,,,,, +12136907,1420,,affects,,Alendronic acid,,,,periodontitis,,,,, +8809813,1421,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +22627610,1422,,disrupts,,Alendronic acid,,,,aortic valve stenosis,,,,, +17047070,1423,,disrupts,,Alendronic acid,,,,prostate cancer,,,,, +9109277,1424,,disrupts,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +8466156,1425,,disrupts,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +24628288,1426,,prevents,,Alendronic acid,,,,osteoarthritis,,,,, +15290647,1427,,prevents,,Alendronic acid,,,,bone disorder,,,,, +7495571,1428,,prevents,,Alendronic acid,,,,osteoporosis,,,,, +7314446,1429,,prevents,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +7150371,1430,,prevents,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +25381093,1431,,predisposes,,Alendronic acid,,,,osteoporosis,,,,, +22975353,1432,,predisposes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +12652815,1433,,related to,,Pamidronic acid,,,,osteoporosis,,,,, +7541169,1434,,related to,,Pamidronic acid,,,,plasma cell myeloma,,,,, +12040766,1435,,affects,,Pamidronic acid,,,,plasma cell myeloma,,,,, +10860757,1436,,affects,,Pamidronic acid,,,,osteoporosis,,,,, +9170219,1437,,prevents,,Pamidronic acid,,,,osteoporosis,,,,, +9315699,1438,,prevents,,Octyl methoxycinnamate,,,,sunburn,,,,, +10529058,1439,,coexists with,,4-Aminobenzoic acid,,,,Procaine,,,,, +25771688,1440,,causes,,Nitrazepam,,,,epilepsy,,,,, +19206956,1441,,affects,,Nitrazepam,,,,depressive disorder,,,,, +25737609,1442,,disrupts,,Nitrazepam,,,,epilepsy,,,,, +7322742,1443,,prevents,,Nitrazepam,,,,epilepsy,,,,, +25779340,1444,,causes,,Flurazepam,,,,depressive disorder,,,,, +19092155,1445,,causes,,Triazolam,,,,depressive disorder,,,,, +16852864,1446,,causes,,Triazolam,,,,insomnia,,,,, +27224077,1447,,affects,,Triazolam,,,,insomnia,,,,, +15159227,1448,,disrupts,,Triazolam,,,,anxiety,,,,, +24702695,1449,,related to,,Midazolam,,,,delirium,,,,, +16327495,1450,,related to,,Midazolam,,,,obesity disorder,,,,, +17503618,1451,,causes,,Midazolam,,,,Nausea,,,,, +13087342,1452,,causes,,Midazolam,,,,status epilepticus,,,,, +12880145,1453,,causes,,Midazolam,,,,delirium,,,,, +12134398,1454,,causes,,Midazolam,,,,brain injury,,,,, +11162624,1455,,causes,,Midazolam,,,,Pain,,,,, +10221339,1456,,causes,,Midazolam,,,,injury,,,,, +10197463,1457,,causes,,Midazolam,,,,epilepsy,,,,, +7739374,1458,,causes,,Midazolam,,,,hypotensive disorder,,,,, +7211473,1459,,causes,,Midazolam,,,,depressive disorder,,,,, +7104276,1460,,causes,,Midazolam,,,,dissociative amnesia,,,,, +27271852,1461,,affects,,Midazolam,,,,Pruritus,,,,, +26121850,1462,,affects,,Midazolam,,,,Pain,,,,, +25522494,1463,,affects,,Midazolam,,,,anxiety,,,,, +22514965,1464,,affects,,Midazolam,,,,anxiety,,,,, +22203290,1465,,affects,,Midazolam,,,,post-traumatic stress disorder,,,,, +21411467,1466,,affects,,Midazolam,,,,Suicidal ideation,,,,, +20820424,1467,,affects,,Midazolam,,,,injury,,,,, +20230773,1468,,affects,,Midazolam,,,,hypotensive disorder,,,,, +19683992,1469,,affects,,Midazolam,,,,injury,,,,, +18986257,1470,,affects,,Midazolam,,,,neoplasm,,,,, +18893940,1471,,affects,,Midazolam,,,,hypertensive disorder,,,,, +18670184,1472,,affects,,Midazolam,,,,hypotensive disorder,,,,, +18644607,1473,,affects,,Midazolam,,,,neuralgia,,,,, +18331473,1474,,affects,,Midazolam,,,,status epilepticus,,,,, +17655582,1475,,affects,,Midazolam,,,,Cough,,,,, +12605496,1476,,affects,,Midazolam,,,,dissociative amnesia,,,,, +12154940,1477,,affects,,Midazolam,,,,Nausea,,,,, +11981571,1478,,affects,,Midazolam,,,,delirium,,,,, +8867560,1479,,affects,,Midazolam,,,,Pain,,,,, +8871799,1480,,affects,,Midazolam,,,,hypotensive disorder,,,,, +8701804,1481,,affects,,Midazolam,,,,epilepsy,,,,, +8569605,1482,,affects,,Midazolam,,,,brain injury,,,,, +7116661,1483,,affects,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, +20025306,1484,,disrupts,,Midazolam,,,,Pruritus,,,,, +18424847,1485,,disrupts,,Midazolam,,,,status epilepticus,,,,, +16150704,1486,,disrupts,,Midazolam,,,,Cough,,,,, +14733481,1487,,disrupts,,Midazolam,,,,neuralgia,,,,, +13861580,1488,,disrupts,,Midazolam,,,,Pain,,,,, +9443524,1489,,disrupts,,Midazolam,,,,epilepsy,,,,, +7819099,1490,,disrupts,,Midazolam,,,,anxiety,,,,, +21663738,1491,,prevents,,Midazolam,,,,anxiety,,,,, +20820423,1492,,prevents,,Midazolam,,,,injury,,,,, +17322994,1493,,prevents,,Midazolam,,,,Aggressive behavior,,,,, +16397367,1494,,prevents,,Midazolam,,,,status epilepticus,,,,, +13467675,1495,,prevents,,Midazolam,,,,Nausea,,,,, +11373548,1496,,prevents,,Midazolam,,,,Cough,,,,, +11041799,1497,,prevents,,Midazolam,,,,bone fracture,,,,, +9493413,1498,,prevents,,Midazolam,,,,epilepsy,,,,, +8653279,1499,,prevents,,Midazolam,,,,Sepsis,,,,, +8569600,1500,,prevents,,Midazolam,,,,brain injury,,,,, +8151023,1501,,prevents,,Midazolam,,,,Pain,,,,, +7116663,1502,,prevents,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, +16657523,1503,,exacerbates,,Midazolam,,,,Sepsis,,,,, +19191198,1504,,predisposes,,Midazolam,,,,dissociative amnesia,,,,, +18422952,1505,,predisposes,,Midazolam,,,,status epilepticus,,,,, +11981572,1506,,predisposes,,Midazolam,,,,delirium,,,,, +22402246,1507,,disrupts,,Brotizolam,,,,anxiety,,,,, +12312025,1508,,related to,,Ganirelix,,,,polycystic ovary syndrome,,,,, +14831488,1509,,disrupts,,Cetrorelix,,,,benign prostatic hyperplasia,,,,, +18703871,1510,,prevents,,Cetrorelix,,,,endometriosis,,,,, +18874469,1511,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +18874469,1512,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +12069194,1513,,related to,,Methoxsalen,,,,mycosis fungoides,,,,, +8610329,1514,,related to,,Methoxsalen,,,,psoriasis,,,,, +26218137,1515,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +26218137,1516,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +7172075,1517,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +7172075,1518,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +26761340,1519,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +26761340,1520,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +7782040,1521,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +12022213,1522,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +9512596,1523,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +19709381,1524,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +8674128,1525,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +8674128,1526,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +8674127,1527,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +25732039,1528,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +16826513,1529,,affects,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +9717834,1530,,related to,,Bisoprolol,,,,hypertensive disorder,,,,, +17484309,1531,,affects,,Bisoprolol,,,,Hemorrhage,,,,, +14633716,1532,,affects,,Bisoprolol,,,,hypertensive disorder,,,,, +13150765,1533,,affects,,Bisoprolol,,,,pulmonary arterial hypertension,,,,, +24626572,1534,,disrupts,,Bisoprolol,,,,Hemorrhage,,,,, +23315135,1535,,prevents,,Bisoprolol,,,,Hemorrhage,,,,, +26817035,1536,,related to,,Esmolol,,,,atrial fibrillation,,,,, +13689489,1537,,causes,,Esmolol,,,,atrial fibrillation,,,,, +20072391,1538,,affects,,Esmolol,,,,toxic shock syndrome,,,,, +19519833,1539,,affects,,Esmolol,,,,Pain,,,,, +16877299,1540,,prevents,,Esmolol,,,,Pain,,,,, +10180097,1541,,prevents,,Esmolol,,,,ischemia reperfusion injury,,,,, +9581320,1542,,prevents,,Esmolol,,,,atrial fibrillation,,,,, +18235527,1543,,related to,,Oxygen,,,,pulmonary fibrosis,,,,, +18193743,1544,,related to,,Oxygen,,,,neoplasm,,,,, +17303485,1545,,related to,,Oxygen,,,,Hypoxemia,,,,, +14116536,1546,,related to,,Oxygen,,,,Shock,,,,, +13587155,1547,,related to,,Oxygen,,,,injury,,,,, +8813011,1548,,related to,,Oxygen,,,,ischemia reperfusion injury,,,,, +21893162,1549,,causes,,Oxygen,,,,neoplasm,,,,, +19992109,1550,,causes,,Oxygen,,,,ischemia reperfusion injury,,,,, +8243272,1551,,causes,,Oxygen,,,,vascular disorder,,,,, +8114891,1552,,causes,,Oxygen,,,,injury,,,,, +7992845,1553,,causes,,Oxygen,,,,Hypoxemia,,,,, +7752235,1554,,causes,,Oxygen,,,,stroke disorder,,,,, +23272853,1555,,affects,,Oxygen,,,,neoplasm,,,,, +22206348,1556,,affects,,Oxygen,,,,neoplasm,,,,, +19397332,1557,,affects,,Oxygen,,,,Hypoxemia,,,,, +13060611,1558,,affects,,Oxygen,,,,Shock,,,,, +13638133,1559,,produces,,Oxygen,,,,Hypoxemia,,,,, +13264427,1560,,produces,,Oxygen,,,,neoplasm,,,,, +12483211,1561,,disrupts,,Oxygen,,,,Hypoxemia,,,,, +11682185,1562,,disrupts,,Oxygen,,,,neoplasm,,,,, +16806319,1563,,prevents,,Oxygen,,,,injury,,,,, +17280500,1564,,predisposes,,Oxygen,,,,injury,,,,, +7575686,1565,,subclass of,,Metoprolol,,,,O-Demethylmetoprolol,,,,, +7575685,1566,,subclass of,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +27359356,1567,,related to,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +27639377,1568,,derives from,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +26548288,1569,,physically interacts with,,Metoprolol,,,,O-Demethylmetoprolol,,,,, +21656554,1570,,physically interacts with,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +27101524,1571,,causes,,Metoprolol,,,,ventricular tachycardia,,,,, +27101519,1572,,causes,,Metoprolol,,,,ventricular fibrillation,,,,, +20648435,1573,,causes,,Metoprolol,,,,cardiac rhythm disease,,,,, +14625318,1574,,causes,,Metoprolol,,,,hypertensive disorder,,,,, +19013861,1575,,affects,,Metoprolol,,,,obesity disorder,,,,, +17630974,1576,,affects,,Metoprolol,,,,coronary artery disorder,,,,, +17630973,1577,,affects,,Metoprolol,,,,atherosclerosis,,,,, +16547648,1578,,affects,,Metoprolol,,,,myocardial infarction,,,,, +12751741,1579,,affects,,Metoprolol,,,,cardiac rhythm disease,,,,, +11341339,1580,,affects,,Metoprolol,,,,hypertensive disorder,,,,, +16802112,1581,,disrupts,,Metoprolol,,,,atrial fibrillation,,,,, +14314818,1582,,disrupts,,Metoprolol,,,,atherosclerosis,,,,, +13648308,1583,,disrupts,,Metoprolol,,,,ventricular tachycardia,,,,, +12510783,1584,,disrupts,,Metoprolol,,,,cardiac rhythm disease,,,,, +16624344,1585,,prevents,,Metoprolol,,,,cardiac rhythm disease,,,,, +13530896,1586,,prevents,,Metoprolol,,,,myocardial infarction,,,,, +13366014,1587,,prevents,,Metoprolol,,,,hypertensive disorder,,,,, +13268090,1588,,prevents,,Metoprolol,,,,ventricular fibrillation,,,,, +9428080,1589,,prevents,,Metoprolol,,,,atrial fibrillation,,,,, +7236533,1590,,prevents,,Metoprolol,,,,atherosclerosis,,,,, +22663349,1591,,predisposes,,Metoprolol,,,,atrial fibrillation,,,,, +25990864,1592,,affects,,Acebutolol,,,,hypertensive disorder,,,,, +25995365,1593,,prevents,,Acebutolol,,,,hypertensive disorder,,,,, +24856753,1594,,affects,,Pretomanid,,,,multidrug-resistant tuberculosis,,,,, +17848125,1595,,related to,,Nitrogen,,,,chronic obstructive pulmonary disease,,,,, +15192685,1596,,related to,,Nitrogen,,,,ischemia reperfusion injury,,,,, +10505101,1597,,related to,,Nitrogen,,,,burn,,,,, +10425490,1598,,related to,,Nitrogen,,,,cystic fibrosis,,,,, +16934805,1599,,causes,,Nitrogen,,,,ischemia reperfusion injury,,,,, +13030867,1600,,affects,,Nitrogen,,,,ischemia reperfusion injury,,,,, +9020164,1601,,affects,,Nitrogen,,,,severe acute respiratory syndrome,,,,, +17493096,1602,,predisposes,,Nitrogen,,,,ischemia reperfusion injury,,,,, +25313239,1603,,related to,,Helium,,,,status asthmaticus,,,,, +12274245,1604,,related to,,Helium,,,,chronic obstructive pulmonary disease,,,,, +15248421,1605,,related to,,Carbon Dioxide,,,,Pain,,,,, +11844945,1606,,related to,,Carbon Dioxide,,,,sleep apnea syndrome,,,,, +10575797,1607,,related to,,Carbon Dioxide,,,,respiratory failure,,,,, +7620110,1608,,related to,,Carbon Dioxide,,,,panic disorder,,,,, +16671036,1609,,causes,,Carbon Dioxide,,,,panic disorder,,,,, +11038318,1610,,causes,,Carbon Dioxide,,,,respiratory failure,,,,, +20071308,1611,,affects,,Carbon Dioxide,,,,Pain,,,,, +15771768,1612,,affects,,Carbon Dioxide,,,,Pain,,,,, +15385933,1613,,affects,,Carbon Dioxide,,,,panic disorder,,,,, +14460813,1614,,affects,,Carbon Dioxide,,,,respiratory failure,,,,, +15294247,1615,,produces,,Carbon Dioxide,,,,respiratory failure,,,,, +11946282,1616,,disrupts,,Carbon Dioxide,,,,Pain,,,,, +17126447,1617,,predisposes,,Carbon Dioxide,,,,Pain,,,,, +11404382,1618,,predisposes,,Carbon Dioxide,,,,panic disorder,,,,, +7432027,1619,,predisposes,,Carbon Dioxide,,,,respiratory failure,,,,, +24776228,1620,,causes,,Ethambutol,,,,tuberculosis,,,,, +25946331,1621,,affects,,Ethambutol,,,,tuberculosis,,,,, +24875144,1622,,affects,,Ethambutol,,,,pulmonary tuberculosis,,,,, +25597027,1623,,disrupts,,Ethambutol,,,,tuberculosis,,,,, +18704735,1624,,prevents,,Ethambutol,,,,tuberculosis,,,,, +14472959,1625,,affects,,Pyrazinamide,,,,pulmonary tuberculosis,,,,, +10149898,1626,,affects,,Pyrazinamide,,,,tuberculosis,,,,, +8080030,1627,,prevents,,Pyrazinamide,,,,tuberculosis,,,,, +27556045,1628,,predisposes,,Pyrazinamide,,,,tuberculosis,,,,, +26376727,1629,,related to,,Androstanolone,,,,hypogonadism,,,,, +22807780,1630,,affects,,Androstanolone,,,,hypogonadism,,,,, +7261548,1631,,related to,,Nebivolol,,,,essential hypertension,,,,, +10251853,1632,,affects,,Nebivolol,,,,hypertensive disorder,,,,, +20026875,1633,,prevents,,Nebivolol,,,,cardiovascular disorder,,,,, +10251855,1634,,prevents,,Nebivolol,,,,hypertensive disorder,,,,, +11558481,1635,,exacerbates,,Nebivolol,,,,hypertensive disorder,,,,, +17527026,1636,,related to,,Landiolol,,,,atrial fibrillation,,,,, +14267268,1637,,affects,,Landiolol,,,,atrial fibrillation,,,,, +16074351,1638,,disrupts,,Landiolol,,,,atrial fibrillation,,,,, +21882778,1639,,prevents,,Landiolol,,,,cardiac rhythm disease,,,,, +14873276,1640,,prevents,,Landiolol,,,,atrial fibrillation,,,,, +20190145,1641,,predisposes,,Landiolol,,,,atrial fibrillation,,,,, +26530979,1642,,related to,,Oxandrolone,,,,nutritional disorder,,,,, +17138340,1643,,related to,,Oxandrolone,,,,Fanconi anemia,,,,, +12117784,1644,,related to,,Oxandrolone,,,,Turner syndrome,,,,, +11269262,1645,,related to,,Oxandrolone,,,,burn,,,,, +7561027,1646,,causes,,Cefepime,,,,toxic shock syndrome,,,,, +19437692,1647,,affects,,Cefepime,,,,bacterial infectious disease,,,,, +17947468,1648,,affects,,Cefepime,,,,infectious disease,,,,, +19800344,1649,,disrupts,,Cefepime,,,,infectious disease,,,,, +26336145,1650,,related to,,Hydrocortisone butyrate,,,,"dermatitis, atopic",,,,, +26243703,1651,,related to,,Hydrocortisone butyrate,,,,skin disorder,,,,, +25968096,1652,,related to,,Hydrocortisone butyrate,,,,psoriasis,,,,, +17603464,1653,,disrupts,,Hydrocortisone butyrate,,,,psoriasis,,,,, +9729745,1654,,related to,,Adapalene,,,,acne,,,,, +8571018,1655,,physically interacts with,,Adapalene,,,,Retinoic Acid Receptor,,,,, +13523825,1656,,related to,,Retinol,,,,eye disorder,,,,, +11015290,1657,,related to,,Retinol,,,,tuberculosis,,,,, +10457909,1658,,related to,,Retinol,,,,acne,,,,, +8518043,1659,,related to,,Retinol,,,,malaria,,,,, +8137103,1660,,related to,,Retinol,,,,vitamin A deficiency,,,,, +7807614,1661,,related to,,Retinol,,,,retinitis pigmentosa,,,,, +9304322,1662,,causes,,Retinol,,,,malaria,,,,, +27090494,1663,,affects,,Retinol,,,,diarrheal disease,,,,, +21959378,1664,,affects,,Retinol,,,,nutritional disorder,,,,, +17401879,1665,,affects,,Retinol,,,,tuberculosis,,,,, +17082512,1666,,affects,,Retinol,,,,acne,,,,, +12962972,1667,,affects,,Retinol,,,,eye disorder,,,,, +12534891,1668,,affects,,Retinol,,,,vitamin A deficiency,,,,, +11508263,1669,,affects,,Retinol,,,,diarrheal disease,,,,, +10941106,1670,,affects,,Retinol,,,,vitamin A deficiency,,,,, +22325993,1671,,produces,,Retinol,,,,Infection,,,,, +23772860,1672,,disrupts,,Retinol,,,,vitamin A deficiency,,,,, +12105339,1673,,disrupts,,Retinol,,,,diarrheal disease,,,,, +24823924,1674,,prevents,,Retinol,,,,Infection,,,,, +17332605,1675,,prevents,,Retinol,,,,malaria,,,,, +11445573,1676,,prevents,,Retinol,,,,nutritional disorder,,,,, +8153477,1677,,prevents,,Retinol,,,,diarrheal disease,,,,, +23860384,1678,,predisposes,,Retinol,,,,nutritional disorder,,,,, +19923430,1679,,predisposes,,Retinol,,,,malaria,,,,, +16391363,1680,,predisposes,,Retinol,,,,tuberculosis,,,,, +15050082,1681,,predisposes,,Retinol,,,,diarrheal disease,,,,, +9744244,1682,,predisposes,,Retinol,,,,vitamin A deficiency,,,,, +18962170,1683,,related to,,Isotretinoin,,,,neuroblastoma,,,,, +16229483,1684,,related to,,Isotretinoin,,,,brain cancer,,,,, +15225681,1685,,related to,,Isotretinoin,,,,acne,,,,, +14091563,1686,,related to,,Isotretinoin,,,,myelodysplastic syndrome,,,,, +9061344,1687,,related to,,Isotretinoin,,,,renal cell carcinoma,,,,, +11768316,1688,,physically interacts with,,Isotretinoin,,,,Retinoic Acid Receptor,,,,, +21199868,1689,,causes,,Isotretinoin,,,,neuroblastoma,,,,, +19803622,1690,,causes,,Isotretinoin,,,,acne,,,,, +19310397,1691,,causes,,Isotretinoin,,,,breast neoplasm,,,,, +13522698,1692,,causes,,Isotretinoin,,,,neoplasm,,,,, +23934527,1693,,affects,,Isotretinoin,,,,neoplasm,,,,, +20382078,1694,,affects,,Isotretinoin,,,,neuroblastoma,,,,, +15927367,1695,,affects,,Isotretinoin,,,,rosacea,,,,, +15330626,1696,,affects,,Isotretinoin,,,,acne,,,,, +11212975,1697,,affects,,Isotretinoin,,,,neoplasm,,,,, +9764204,1698,,affects,,Isotretinoin,,,,acne,,,,, +21476432,1699,,disrupts,,Isotretinoin,,,,neuroblastoma,,,,, +14724193,1700,,disrupts,,Isotretinoin,,,,neoplasm,,,,, +14863864,1701,,prevents,,Isotretinoin,,,,acne,,,,, +8312321,1702,,prevents,,Isotretinoin,,,,neoplasm,,,,, +15444114,1703,,exacerbates,,Isotretinoin,,,,ichthyosis,,,,, +15310461,1704,,predisposes,,Isotretinoin,,,,acne,,,,, +24593446,1705,,affects,,Trifarotene,,,,acne,,,,, +21448312,1706,,affects,,Atazanavir,,,,AIDS,,,,, +24947472,1707,,disrupts,,Atazanavir,,,,HIV infectious disease,,,,, +13198660,1708,,disrupts,,Atazanavir,,,,AIDS,,,,, +20253995,1709,,prevents,,Atazanavir,,,,AIDS,,,,, +8134603,1710,,affects,,Saquinavir,,,,HIV infectious disease,,,,, +16320598,1711,,disrupts,,Saquinavir,,,,viral infectious disease,,,,, +13198658,1712,,disrupts,,Saquinavir,,,,AIDS,,,,, +17107608,1713,,prevents,,Saquinavir,,,,HIV infectious disease,,,,, +12560548,1714,,prevents,,Indinavir,,,,viral infectious disease,,,,, +15113750,1715,,related to,,Ritonavir,,,,AIDS,,,,, +7566746,1716,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +7566746,1717,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +15583404,1718,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +15583404,1719,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +11500913,1720,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +8329957,1721,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +8452370,1722,,causes,,Ritonavir,,,,AIDS,,,,, +21492333,1723,,affects,,Ritonavir,,,,neoplasm,,,,, +12140603,1724,,affects,,Ritonavir,,,,Insulin resistance,,,,, +9520105,1725,,affects,,Ritonavir,,,,HIV infectious disease,,,,, +7566745,1726,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +15873481,1727,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +21820102,1728,,disrupts,,Ritonavir,,,,Coronavinae infectious disease,,,,, +15656958,1729,,disrupts,,Ritonavir,,,,HIV infectious disease,,,,, +9520113,1730,,disrupts,,Ritonavir,,,,neoplasm,,,,, +22737012,1731,,prevents,,Ritonavir,,,,neoplasm,,,,, +10934319,1732,,prevents,,Ritonavir,,,,Kaposi's sarcoma,,,,, +12915909,1733,,causes,,Nelfinavir,,,,diarrheal disease,,,,, +19184628,1734,,affects,,Nelfinavir,,,,neoplasm,,,,, +16087478,1735,,affects,,Nelfinavir,,,,plasma cell myeloma,,,,, +11272488,1736,,affects,,Nelfinavir,,,,diarrheal disease,,,,, +10940786,1737,,affects,,Thiopental,,,,brain injury,,,,, +7790675,1738,,prevents,,Thiopental,,,,brain injury,,,,, +26262897,1739,,causes,,Pentobarbital,,,,insomnia,,,,, +25778415,1740,,affects,,Pentobarbital,,,,insomnia,,,,, +13642757,1741,,disrupts,,Pentobarbital,,,,status epilepticus,,,,, +23761012,1742,,prevents,,Amobarbital,,,,osteoarthritis,,,,, +26983984,1743,,causes,,Moxisylyte,,,,erectile dysfunction,,,,, +26385811,1744,,prevents,,Mepyramine,,,,allergic disease,,,,, +27140633,1745,,subclass of,,Promethazine,,,,Promethazine sulfoxide,,,,, +19124534,1746,,related to,,Promethazine,,,,Vomiting,,,,, +26252918,1747,,causes,,Promethazine,,,,Vomiting,,,,, +8157500,1748,,causes,,Promethazine,,,,depressive disorder,,,,, +19547748,1749,,affects,,Promethazine,,,,Vomiting,,,,, +12404928,1750,,affects,,Promethazine,,,,Pruritus,,,,, +10742218,1751,,affects,,Promethazine,,,,Nausea,,,,, +10228295,1752,,affects,,Promethazine,,,,central nervous system origin vertigo,,,,, +7912966,1753,,affects,,Promethazine,,,,Vomiting,,,,, +13616931,1754,,disrupts,,Promethazine,,,,Nausea,,,,, +17497020,1755,,prevents,,Promethazine,,,,central nervous system origin vertigo,,,,, +11541778,1756,,prevents,,Promethazine,,,,Pruritus,,,,, +7912965,1757,,prevents,,Promethazine,,,,Vomiting,,,,, +7912964,1758,,prevents,,Promethazine,,,,Nausea,,,,, +25750000,1759,,causes,,Clemastine,,,,urticaria,,,,, +25747466,1760,,affects,,Clemastine,,,,urticaria,,,,, +19433677,1761,,affects,,Clemastine,,,,Pruritus,,,,, +25634655,1762,,disrupts,,Clemastine,,,,urticaria,,,,, +24612586,1763,,prevents,,Clemastine,,,,urticaria,,,,, +17916924,1764,,prevents,,Clemastine,,,,dermatitis,,,,, +24699384,1765,,predisposes,,Clemastine,,,,allergic disease,,,,, +25081855,1766,,affects,,Tiapride,,,,Dopamine D2 Receptor,,,,, +19553406,1767,,causes,,Amisulpride,,,,schizophrenia,,,,, +9337142,1768,,causes,,Amisulpride,,,,psychotic disorder,,,,, +24415555,1769,,affects,,Amisulpride,,,,depressive disorder,,,,, +8493076,1770,,affects,,Amisulpride,,,,schizophrenia,,,,, +20532376,1771,,prevents,,Amisulpride,,,,Postoperative Nausea and Vomiting,,,,, +19821343,1772,,prevents,,Amisulpride,,,,Nausea,,,,, +11149280,1773,,physically interacts with,,Remoxipride,,,,Dopamine D2 Receptor,,,,, +9174370,1774,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, +24158881,1775,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, +20394421,1776,,affects,,Levosulpiride,,,,Dopamine D2 Receptor,,,,, +26880772,1777,,related to,,Nitroglycerin,,,,coronary artery disorder,,,,, +26139329,1778,,related to,,Nitroglycerin,,,,hypertensive disorder,,,,, +21173297,1779,,related to,,Nitroglycerin,,,,injury,,,,, +26585664,1780,,causes,,Nitroglycerin,,,,Raynaud disease,,,,, +26278376,1781,,causes,,Nitroglycerin,,,,Angina pectoris,,,,, +26148974,1782,,causes,,Nitroglycerin,,,,myocardial infarction,,,,, +15949436,1783,,causes,,Nitroglycerin,,,,injury,,,,, +15624022,1784,,causes,,Nitroglycerin,,,,Inflammation,,,,, +14985558,1785,,causes,,Nitroglycerin,,,,hypertensive disorder,,,,, +8402702,1786,,causes,,Nitroglycerin,,,,Pain,,,,, +7629693,1787,,causes,,Nitroglycerin,,,,hypotensive disorder,,,,, +26786108,1788,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, +26278652,1789,,affects,,Nitroglycerin,,,,hypotensive disorder,,,,, +25994904,1790,,affects,,Nitroglycerin,,,,Raynaud disease,,,,, +25747829,1791,,affects,,Nitroglycerin,,,,erectile dysfunction,,,,, +25260538,1792,,affects,,Nitroglycerin,,,,Muscle spasm,,,,, +23178151,1793,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, +20885558,1794,,affects,,Nitroglycerin,,,,injury,,,,, +18491008,1795,,affects,,Nitroglycerin,,,,Hot flashes,,,,, +14421188,1796,,affects,,Nitroglycerin,,,,Angina pectoris,,,,, +13478654,1797,,affects,,Nitroglycerin,,,,osteoporosis,,,,, +11707783,1798,,affects,,Nitroglycerin,,,,Pain,,,,, +11174035,1799,,affects,,Nitroglycerin,,,,hypertensive disorder,,,,, +10595566,1800,,affects,,Nitroglycerin,,,,stroke disorder,,,,, +8601510,1801,,affects,,Nitroglycerin,,,,myocardial ischemia,,,,, +8521770,1802,,affects,,Nitroglycerin,,,,phlebitis,,,,, +8049127,1803,,affects,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, +26813951,1804,,disrupts,,Nitroglycerin,,,,myocardial ischemia,,,,, +26590847,1805,,disrupts,,Nitroglycerin,,,,hypertensive disorder,,,,, +24386334,1806,,disrupts,,Nitroglycerin,,,,phlebitis,,,,, +19274234,1807,,disrupts,,Nitroglycerin,,,,injury,,,,, +10081147,1808,,disrupts,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, +9796564,1809,,disrupts,,Nitroglycerin,,,,Pain,,,,, +25569906,1810,,prevents,,Nitroglycerin,,,,phlebitis,,,,, +21983895,1811,,prevents,,Nitroglycerin,,,,Muscle spasm,,,,, +20473117,1812,,prevents,,Nitroglycerin,,,,Inflammation,,,,, +18491009,1813,,prevents,,Nitroglycerin,,,,Hot flashes,,,,, +17804368,1814,,prevents,,Nitroglycerin,,,,hypertensive disorder,,,,, +11496690,1815,,prevents,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, +10695579,1816,,prevents,,Nitroglycerin,,,,Angina pectoris,,,,, +10573276,1817,,prevents,,Nitroglycerin,,,,myocardial infarction,,,,, +9096899,1818,,prevents,,Nitroglycerin,,,,Pain,,,,, +9057729,1819,,prevents,,Nitroglycerin,,,,Shock,,,,, +8235862,1820,,prevents,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, +7713034,1821,,prevents,,Nitroglycerin,,,,injury,,,,, +13750741,1822,,exacerbates,,Nitroglycerin,,,,myocardial ischemia,,,,, +20483551,1823,,predisposes,,Nitroglycerin,,,,myocardial ischemia,,,,, +9897513,1824,,predisposes,,Nitroglycerin,,,,Angina pectoris,,,,, +20924645,1825,,related to,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, +10616906,1826,,related to,,Isosorbide dinitrate,,,,Angina pectoris,,,,, +9112334,1827,,related to,,Isosorbide dinitrate,,,,coronary artery disorder,,,,, +26334868,1828,,affects,,Isosorbide dinitrate,,,,Angina pectoris,,,,, +10884689,1829,,affects,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, +9112335,1830,,prevents,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, +17782283,1831,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, +7084056,1832,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, +25690684,1833,,causes,,Sulpiride,,,,depressive disorder,,,,, +26343015,1834,,affects,,Sulpiride,,,,schizophrenia,,,,, +23882267,1835,,affects,,Sulpiride,,,,anxiety,,,,, +8960439,1836,,affects,,Sulpiride,,,,depressive disorder,,,,, +8364166,1837,,affects,,Sulpiride,,,,Dopamine D2 Receptor,,,,, +7538297,1838,,affects,,Sulpiride,,,,depressive disorder,,,,, +25756981,1839,,disrupts,,Sulpiride,,,,depressive disorder,,,,, +8859505,1840,,disrupts,,Sulpiride,,,,anxiety,,,,, +26753868,1841,,causes,,Isosorbide mononitrate,,,,Angina pectoris,,,,, +15856723,1842,,affects,,Isosorbide mononitrate,,,,Angina pectoris,,,,, +24979081,1843,,prevents,,Isosorbide mononitrate,,,,vascular disorder,,,,, +22319748,1844,,prevents,,Isosorbide mononitrate,,,,Angina pectoris,,,,, +23203614,1845,,related to,,Ribociclib,,,,squamous cell carcinoma,,,,, +23890460,1846,,related to,,Abemaciclib,,,,non-small cell lung carcinoma,,,,, +24133672,1847,,affects,,Abemaciclib,,,,neoplasm,,,,, +23820208,1848,,disrupts,,Abemaciclib,,,,neoplasm,,,,, +7114439,1849,,subclass of,,Sodium Chloride,,,,Electrolytes,,,,, +27178225,1850,,related to,,Sodium Chloride,,,,hypoglycemia,,,,, +26906663,1851,,related to,,Sodium Chloride,,,,ventricular septal defect,,,,, +26538206,1852,,related to,,Sodium Chloride,,,,papilloma,,,,, +26529472,1853,,related to,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, +26267091,1854,,related to,,Sodium Chloride,,,,Sepsis,,,,, +26209731,1855,,related to,,Sodium Chloride,,,,cataract,,,,, +25917183,1856,,related to,,Sodium Chloride,,,,Hypoxemia,,,,, +20673450,1857,,related to,,Sodium Chloride,,,,Alzheimer disease,,,,, +20617514,1858,,related to,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, +20321366,1859,,related to,,Sodium Chloride,,,,type 1 diabetes mellitus,,,,, +19962817,1860,,related to,,Sodium Chloride,,,,Inflammation,,,,, +19891172,1861,,related to,,Sodium Chloride,,,,acute lung injury,,,,, +19636264,1862,,related to,,Sodium Chloride,,,,ischemic disease,,,,, +19577743,1863,,related to,,Sodium Chloride,,,,spinal cord injury,,,,, +19497082,1864,,related to,,Sodium Chloride,,,,primary ciliary dyskinesia,,,,, +18975700,1865,,related to,,Sodium Chloride,,,,bacterial infectious disease,,,,, +18966398,1866,,related to,,Sodium Chloride,,,,osteoarthritis,,,,, +18860303,1867,,related to,,Sodium Chloride,,,,bone fracture,,,,, +18738706,1868,,related to,,Sodium Chloride,,,,toxic shock syndrome,,,,, +18679247,1869,,related to,,Sodium Chloride,,,,Electrolytes,,,,, +18617363,1870,,related to,,Sodium Chloride,,,,iron deficiency anemia,,,,, +18287282,1871,,related to,,Sodium Chloride,,,,Pruritus,,,,, +17603340,1872,,related to,,Sodium Chloride,,,,brain injury,,,,, +17533385,1873,,related to,,Sodium Chloride,,,,myocardial infarction,,,,, +17525035,1874,,related to,,Sodium Chloride,,,,coronary artery disorder,,,,, +17213013,1875,,related to,,Sodium Chloride,,,,hepatocellular carcinoma,,,,, +17202845,1876,,related to,,Sodium Chloride,,,,Parkinson disease,,,,, +16886803,1877,,related to,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +16594665,1878,,related to,,Sodium Chloride,,,,Pain,,,,, +16433967,1879,,related to,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, +15412515,1880,,related to,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, +14710472,1881,,related to,,Sodium Chloride,,,,bronchiolitis,,,,, +14037713,1882,,related to,,Sodium Chloride,,,,ventricular tachycardia,,,,, +13928740,1883,,related to,,Sodium Chloride,,,,pulmonary edema,,,,, +13375642,1884,,related to,,Sodium Chloride,,,,Insulin resistance,,,,, +13343201,1885,,related to,,Sodium Chloride,,,,Hypernatremia,,,,, +13277977,1886,,related to,,Sodium Chloride,,,,diabetic ketoacidosis,,,,, +11905993,1887,,related to,,Sodium Chloride,,,,depressive disorder,,,,, +11014479,1888,,related to,,Sodium Chloride,,,,glaucoma,,,,, +10966302,1889,,related to,,Sodium Chloride,,,,malaria,,,,, +10739226,1890,,related to,,Sodium Chloride,,,,heart disorder,,,,, +10689901,1891,,related to,,Sodium Chloride,,,,diabetes mellitus,,,,, +10566407,1892,,related to,,Sodium Chloride,,,,brain cancer,,,,, +10531148,1893,,related to,,Sodium Chloride,,,,kidney failure,,,,, +10510273,1894,,related to,,Sodium Chloride,,,,Shock,,,,, +10504585,1895,,related to,,Sodium Chloride,,,,tuberculosis,,,,, +10502982,1896,,related to,,Sodium Chloride,,,,nutritional disorder,,,,, +10502981,1897,,related to,,Sodium Chloride,,,,cirrhosis of liver,,,,, +10487095,1898,,related to,,Sodium Chloride,,,,pneumonia,,,,, +10439781,1899,,related to,,Sodium Chloride,,,,acute kidney failure,,,,, +10433628,1900,,related to,,Sodium Chloride,,,,psoriasis,,,,, +10370762,1901,,related to,,Sodium Chloride,,,,Hypothermia,,,,, +10318383,1902,,related to,,Sodium Chloride,,,,cardiovascular disorder,,,,, +10300324,1903,,related to,,Sodium Chloride,,,,stroke disorder,,,,, +10268953,1904,,related to,,Sodium Chloride,,,,brain edema,,,,, +9985623,1905,,related to,,Sodium Chloride,,,,Nausea,,,,, +9642141,1906,,related to,,Sodium Chloride,,,,obesity disorder,,,,, +9504754,1907,,related to,,Sodium Chloride,,,,asthma,,,,, +9350794,1908,,related to,,Sodium Chloride,,,,essential hypertension,,,,, +9217528,1909,,related to,,Sodium Chloride,,,,dry eye syndrome,,,,, +8489872,1910,,related to,,Sodium Chloride,,,,injury,,,,, +8486278,1911,,related to,,Sodium Chloride,,,,cystic fibrosis,,,,, +7822303,1912,,related to,,Sodium Chloride,,,,neoplasm,,,,, +7455347,1913,,related to,,Sodium Chloride,,,,Hypovolemia,,,,, +7397406,1914,,related to,,Sodium Chloride,,,,kidney disorder,,,,, +7259411,1915,,related to,,Sodium Chloride,,,,hypertensive disorder,,,,, +19769676,1916,,related to,,Sodium Chloride,,,,Electrolytes,,,,, +18679248,1917,,close match,,Sodium Chloride,,,,Electrolytes,,,,, +7792933,1918,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, +9181325,1919,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, +27223278,1920,,derives from,,Sodium Chloride,,,,Electrolytes,,,,, +9585905,1921,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, +9585904,1922,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, +26947391,1923,,causes,,Sodium Chloride,,,,acute kidney tubular necrosis,,,,, +26813055,1924,,causes,,Sodium Chloride,,,,Dyspnea,,,,, +26651944,1925,,causes,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, +26200221,1926,,causes,,Sodium Chloride,,,,melanoma,,,,, +25963723,1927,,causes,,Sodium Chloride,,,,cardiac arrest,,,,, +24999522,1928,,causes,,Sodium Chloride,,,,Nausea,,,,, +23507574,1929,,causes,,Sodium Chloride,,,,burn,,,,, +21365055,1930,,causes,,Sodium Chloride,,,,respiratory failure,,,,, +20716492,1931,,causes,,Sodium Chloride,,,,multiple organ dysfunction syndrome,,,,, +20666627,1932,,causes,,Sodium Chloride,,,,malaria,,,,, +20168868,1933,,causes,,Sodium Chloride,,,,fibromyalgia,,,,, +19652731,1934,,causes,,Sodium Chloride,,,,Chronic pain,,,,, +19581650,1935,,causes,,Sodium Chloride,,,,neoplasm,,,,, +19527177,1936,,causes,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, +19434783,1937,,causes,,Sodium Chloride,,,,Low back pain,,,,, +19352698,1938,,causes,,Sodium Chloride,,,,bone fracture,,,,, +19268574,1939,,causes,,Sodium Chloride,,,,ulcerative colitis,,,,, +18873789,1940,,causes,,Sodium Chloride,,,,preeclampsia,,,,, +18760766,1941,,causes,,Sodium Chloride,,,,heart disorder,,,,, +18419412,1942,,causes,,Sodium Chloride,,,,infertility disorder,,,,, +18184755,1943,,causes,,Sodium Chloride,,,,intervertebral disc degenerative disorder,,,,, +18174270,1944,,causes,,Sodium Chloride,,,,asthma,,,,, +17957169,1945,,causes,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, +17846702,1946,,causes,,Sodium Chloride,,,,cardiovascular disorder,,,,, +17472790,1947,,causes,,Sodium Chloride,,,,Postoperative Complications,,,,, +17050802,1948,,causes,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, +16922792,1949,,causes,,Sodium Chloride,,,,aortic aneurysm,,,,, +16902385,1950,,causes,,Sodium Chloride,,,,Hypoxemia,,,,, +16884655,1951,,causes,,Sodium Chloride,,,,obesity disorder,,,,, +15862216,1952,,causes,,Sodium Chloride,,,,Sepsis,,,,, +15183436,1953,,causes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +14507617,1954,,causes,,Sodium Chloride,,,,brain edema,,,,, +14335740,1955,,causes,,Sodium Chloride,,,,essential hypertension,,,,, +14100671,1956,,causes,,Sodium Chloride,,,,Cough,,,,, +13899816,1957,,causes,,Sodium Chloride,,,,brain injury,,,,, +13415978,1958,,causes,,Sodium Chloride,,,,rhinitis,,,,, +13156241,1959,,causes,,Sodium Chloride,,,,allergic disease,,,,, +12922926,1960,,causes,,Sodium Chloride,,,,periodontitis,,,,, +12796728,1961,,causes,,Sodium Chloride,,,,myocardial infarction,,,,, +12757253,1962,,causes,,Sodium Chloride,,,,urticaria,,,,, +12052924,1963,,causes,,Sodium Chloride,,,,Fever,,,,, +11367442,1964,,causes,,Sodium Chloride,,,,Hypothermia,,,,, +10844905,1965,,causes,,Sodium Chloride,,,,kidney disorder,,,,, +10703852,1966,,causes,,Sodium Chloride,,,,Ascites,,,,, +10680402,1967,,causes,,Sodium Chloride,,,,kidney failure,,,,, +10468869,1968,,causes,,Sodium Chloride,,,,Hyperhidrosis,,,,, +10303736,1969,,causes,,Sodium Chloride,,,,Hemorrhage,,,,, +10216492,1970,,causes,,Sodium Chloride,,,,Insulin resistance,,,,, +9649854,1971,,causes,,Sodium Chloride,,,,Inflammation,,,,, +9417058,1972,,causes,,Sodium Chloride,,,,stroke disorder,,,,, +9370401,1973,,causes,,Sodium Chloride,,,,acute kidney failure,,,,, +9311776,1974,,causes,,Sodium Chloride,,,,hypotensive disorder,,,,, +8912328,1975,,causes,,Sodium Chloride,,,,injury,,,,, +8760965,1976,,causes,,Sodium Chloride,,,,hyperinsulinism,,,,, +8723767,1977,,causes,,Sodium Chloride,,,,Hyponatremia,,,,, +8658207,1978,,causes,,Sodium Chloride,,,,ischemic disease,,,,, +8215909,1979,,causes,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, +7966995,1980,,causes,,Sodium Chloride,,,,Shock,,,,, +7871886,1981,,causes,,Sodium Chloride,,,,Hypernatremia,,,,, +7769838,1982,,causes,,Sodium Chloride,,,,Pain,,,,, +7535626,1983,,causes,,Sodium Chloride,,,,pulmonary edema,,,,, +7170398,1984,,causes,,Sodium Chloride,,,,cataract,,,,, +7067270,1985,,causes,,Sodium Chloride,,,,hypertensive disorder,,,,, +27640062,1986,,affects,,Sodium Chloride,,,,hyperinsulinism,,,,, +27459630,1987,,affects,,Sodium Chloride,,,,ischemic disease,,,,, +26883243,1988,,affects,,Sodium Chloride,,,,pulmonary edema,,,,, +25873721,1989,,affects,,Sodium Chloride,,,,stroke disorder,,,,, +25698961,1990,,affects,,Sodium Chloride,,,,Hypovolemia,,,,, +23350231,1991,,affects,,Sodium Chloride,,,,allergic disease,,,,, +21279163,1992,,affects,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, +19916489,1993,,affects,,Sodium Chloride,,,,malaria,,,,, +19654566,1994,,affects,,Sodium Chloride,,,,Fever,,,,, +19387644,1995,,affects,,Sodium Chloride,,,,Dyspnea,,,,, +19198162,1996,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, +19068195,1997,,affects,,Sodium Chloride,,,,Pain,,,,, +18857149,1998,,affects,,Sodium Chloride,,,,injury,,,,, +18063112,1999,,affects,,Sodium Chloride,,,,myocardial infarction,,,,, +17981225,2000,,affects,,Sodium Chloride,,,,Fever,,,,, +17956116,2001,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, +17749046,2002,,affects,,Sodium Chloride,,,,asthma,,,,, +17453252,2003,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, +17320603,2004,,affects,,Sodium Chloride,,,,brain injury,,,,, +17252322,2005,,affects,,Sodium Chloride,,,,iron deficiency anemia,,,,, +17081119,2006,,affects,,Sodium Chloride,,,,cataract,,,,, +17021361,2007,,affects,,Sodium Chloride,,,,urticaria,,,,, +16829226,2008,,affects,,Sodium Chloride,,,,osteoarthritis,,,,, +16392979,2009,,affects,,Sodium Chloride,,,,Sepsis,,,,, +16339812,2010,,affects,,Sodium Chloride,,,,Inflammation,,,,, +16191401,2011,,affects,,Sodium Chloride,,,,Shock,,,,, +16150899,2012,,affects,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, +15784044,2013,,affects,,Sodium Chloride,,,,Electrolytes,,,,, +15684126,2014,,affects,,Sodium Chloride,,,,malaria,,,,, +15518572,2015,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +15358630,2016,,affects,,Sodium Chloride,,,,brain injury,,,,, +14974493,2017,,affects,,Sodium Chloride,,,,cardiovascular disorder,,,,, +14875621,2018,,affects,,Sodium Chloride,,,,Hypoxemia,,,,, +14652078,2019,,affects,,Sodium Chloride,,,,preeclampsia,,,,, +14650670,2020,,affects,,Sodium Chloride,,,,Ascites,,,,, +14454543,2021,,affects,,Sodium Chloride,,,,Inflammation,,,,, +14269847,2022,,affects,,Sodium Chloride,,,,kidney disorder,,,,, +13713189,2023,,affects,,Sodium Chloride,,,,acute lung injury,,,,, +13361928,2024,,affects,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +13091031,2025,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +12113298,2026,,affects,,Sodium Chloride,,,,diabetes mellitus,,,,, +11936868,2027,,affects,,Sodium Chloride,,,,allergic disease,,,,, +11761266,2028,,affects,,Sodium Chloride,,,,stroke disorder,,,,, +11373059,2029,,affects,,Sodium Chloride,,,,Pain,,,,, +11352407,2030,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, +10762234,2031,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, +10689150,2032,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, +10555492,2033,,affects,,Sodium Chloride,,,,nutritional disorder,,,,, +10543207,2034,,affects,,Sodium Chloride,,,,myocarditis,,,,, +10409590,2035,,affects,,Sodium Chloride,,,,essential hypertension,,,,, +10373089,2036,,affects,,Sodium Chloride,,,,Hypernatremia,,,,, +10347664,2037,,affects,,Sodium Chloride,,,,neoplasm,,,,, +10303742,2038,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, +10216887,2039,,affects,,Sodium Chloride,,,,Shock,,,,, +10038950,2040,,affects,,Sodium Chloride,,,,injury,,,,, +9833746,2041,,affects,,Sodium Chloride,,,,obesity disorder,,,,, +9701968,2042,,affects,,Sodium Chloride,,,,brain edema,,,,, +9235049,2043,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, +9211629,2044,,affects,,Sodium Chloride,,,,asthma,,,,, +8885675,2045,,affects,,Sodium Chloride,,,,Ascites,,,,, +8142503,2046,,affects,,Sodium Chloride,,,,Insulin resistance,,,,, +7538296,2047,,affects,,Sodium Chloride,,,,depressive disorder,,,,, +7487288,2048,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, +7249676,2049,,affects,,Sodium Chloride,,,,Fever,,,,, +7189372,2050,,affects,,Sodium Chloride,,,,depressive disorder,,,,, +7186849,2051,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, +7146026,2052,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, +10370500,2053,,affects,,Sodium Chloride,,,,Electrolytes,,,,, +14010559,2054,,produces,,Sodium Chloride,,,,hypertensive disorder,,,,, +25864505,2055,,disrupts,,Sodium Chloride,,,,malaria,,,,, +19817939,2056,,disrupts,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, +19569177,2057,,disrupts,,Sodium Chloride,,,,anxiety,,,,, +19347835,2058,,disrupts,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +19339201,2059,,disrupts,,Sodium Chloride,,,,Cough,,,,, +18711875,2060,,disrupts,,Sodium Chloride,,,,pulmonary edema,,,,, +18638520,2061,,disrupts,,Sodium Chloride,,,,brain edema,,,,, +18394970,2062,,disrupts,,Sodium Chloride,,,,Inflammation,,,,, +17319016,2063,,disrupts,,Sodium Chloride,,,,dental caries,,,,, +17223012,2064,,disrupts,,Sodium Chloride,,,,hypertensive disorder,,,,, +17223011,2065,,disrupts,,Sodium Chloride,,,,cardiovascular disorder,,,,, +17009512,2066,,disrupts,,Sodium Chloride,,,,allergic disease,,,,, +13585452,2067,,disrupts,,Sodium Chloride,,,,neoplasm,,,,, +12586414,2068,,disrupts,,Sodium Chloride,,,,Hypoxemia,,,,, +12214170,2069,,disrupts,,Sodium Chloride,,,,injury,,,,, +10927798,2070,,disrupts,,Sodium Chloride,,,,stroke disorder,,,,, +8273399,2071,,disrupts,,Sodium Chloride,,,,Pain,,,,, +27207716,2072,,prevents,,Sodium Chloride,,,,periodontal disorder,,,,, +27075073,2073,,prevents,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, +23771600,2074,,prevents,,Sodium Chloride,,,,sinusitis,,,,, +21279166,2075,,prevents,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, +20586429,2076,,prevents,,Sodium Chloride,,,,stroke disorder,,,,, +20472317,2077,,prevents,,Sodium Chloride,,,,myocardial infarction,,,,, +20150308,2078,,prevents,,Sodium Chloride,,,,Chronic pain,,,,, +20050861,2079,,prevents,,Sodium Chloride,,,,Dyspnea,,,,, +19622277,2080,,prevents,,Sodium Chloride,,,,Pruritus,,,,, +19347836,2081,,prevents,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +18643598,2082,,prevents,,Sodium Chloride,,,,ventricular tachycardia,,,,, +18145237,2083,,prevents,,Sodium Chloride,,,,Nausea,,,,, +17285701,2084,,prevents,,Sodium Chloride,,,,neuralgia,,,,, +17081118,2085,,prevents,,Sodium Chloride,,,,cataract,,,,, +16603496,2086,,prevents,,Sodium Chloride,,,,brain injury,,,,, +16427621,2087,,prevents,,Sodium Chloride,,,,diabetes mellitus,,,,, +16310359,2088,,prevents,,Sodium Chloride,,,,burn,,,,, +16010295,2089,,prevents,,Sodium Chloride,,,,ischemic disease,,,,, +15507954,2090,,prevents,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, +15307837,2091,,prevents,,Sodium Chloride,,,,acute lung injury,,,,, +15219283,2092,,prevents,,Sodium Chloride,,,,allergic disease,,,,, +14919203,2093,,prevents,,Sodium Chloride,,,,spinal cord injury,,,,, +14359710,2094,,prevents,,Sodium Chloride,,,,obesity disorder,,,,, +14313516,2095,,prevents,,Sodium Chloride,,,,Inflammation,,,,, +14313515,2096,,prevents,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +13297854,2097,,prevents,,Sodium Chloride,,,,kidney disorder,,,,, +12464836,2098,,prevents,,Sodium Chloride,,,,malaria,,,,, +12453134,2099,,prevents,,Sodium Chloride,,,,iron deficiency anemia,,,,, +12276610,2100,,prevents,,Sodium Chloride,,,,essential hypertension,,,,, +12092501,2101,,prevents,,Sodium Chloride,,,,hypertensive disorder,,,,, +11205687,2102,,prevents,,Sodium Chloride,,,,acute kidney failure,,,,, +10429352,2103,,prevents,,Sodium Chloride,,,,injury,,,,, +10205494,2104,,prevents,,Sodium Chloride,,,,Hypovolemia,,,,, +9628485,2105,,prevents,,Sodium Chloride,,,,anemia,,,,, +8227059,2106,,prevents,,Sodium Chloride,,,,Shock,,,,, +8196581,2107,,prevents,,Sodium Chloride,,,,dental caries,,,,, +8059428,2108,,prevents,,Sodium Chloride,,,,Pain,,,,, +22103068,2109,,exacerbates,,Sodium Chloride,,,,hypertensive disorder,,,,, +20308305,2110,,exacerbates,,Sodium Chloride,,,,Inflammation,,,,, +21816011,2111,,predisposes,,Sodium Chloride,,,,essential hypertension,,,,, +19774957,2112,,predisposes,,Sodium Chloride,,,,pulmonary edema,,,,, +18380691,2113,,predisposes,,Sodium Chloride,,,,myocardial infarction,,,,, +18041213,2114,,predisposes,,Sodium Chloride,,,,Inflammation,,,,, +16033022,2115,,predisposes,,Sodium Chloride,,,,injury,,,,, +13840593,2116,,predisposes,,Sodium Chloride,,,,allergic disease,,,,, +13808663,2117,,predisposes,,Sodium Chloride,,,,diabetes mellitus,,,,, +13731023,2118,,predisposes,,Sodium Chloride,,,,cardiovascular disorder,,,,, +12280034,2119,,predisposes,,Sodium Chloride,,,,neoplasm,,,,, +12079247,2120,,predisposes,,Sodium Chloride,,,,hypertensive disorder,,,,, +11776631,2121,,predisposes,,Sodium Chloride,,,,stroke disorder,,,,, +11266800,2122,,predisposes,,Sodium Chloride,,,,kidney disorder,,,,, +10118531,2123,,predisposes,,Sodium Chloride,,,,obesity disorder,,,,, +9111875,2124,,predisposes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +9647073,2125,,related to,,Dexpanthenol,,,,skin disorder,,,,, +26305399,2126,,affects,,Dexpanthenol,,,,Erythema,,,,, +25421467,2127,,prevents,,Dexpanthenol,,,,cheilitis,,,,, +24024712,2128,,related to,,ELTROMBOPAG,,,,autoimmune thrombocytopenic purpura,,,,, +22097814,2129,,related to,,ELTROMBOPAG,,,,acute myeloid leukemia,,,,, +22063304,2130,,related to,,ELTROMBOPAG,,,,aplastic anemia,,,,, +22063303,2131,,related to,,ELTROMBOPAG,,,,myelodysplastic syndrome,,,,, +22049758,2132,,related to,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +23835836,2133,,causes,,ELTROMBOPAG,,,,anemia,,,,, +22601227,2134,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +21709185,2135,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +22821304,2136,,prevents,,ELTROMBOPAG,,,,Hemorrhage,,,,, +22169266,2137,,prevents,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +12546229,2138,,affects,,Etamsylate,,,,Hemorrhage,,,,, +9791897,2139,,affects,,Etamsylate,,,,Hemorrhage,,,,, +22608563,2140,,prevents,,Etamsylate,,,,Hemorrhage,,,,, +26536250,2141,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +26536250,2142,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +26158944,2143,,related to,,mitomycin C,,,,adenocarcinoma,,,,, +26111339,2144,,related to,,mitomycin C,,,,squamous cell carcinoma,,,,, +26043076,2145,,related to,,mitomycin C,,,,neoplasm,,,,, +25722815,2146,,related to,,mitomycin C,,,,leukemia,,,,, +12722759,2147,,related to,,mitomycin C,,,,carcinoma,,,,, +10467532,2148,,related to,,mitomycin C,,,,non-small cell lung carcinoma,,,,, +7255625,2149,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +7255625,2150,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8689799,2151,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8689799,2152,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8030161,2153,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8030161,2154,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +7255626,2155,,physically interacts with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +25769130,2156,,causes,,mitomycin C,,,,sarcoma,,,,, +25692678,2157,,causes,,mitomycin C,,,,hepatocellular carcinoma,,,,, +20975852,2158,,causes,,mitomycin C,,,,carcinoma,,,,, +12184177,2159,,causes,,mitomycin C,,,,Corneal opacity,,,,, +11626710,2160,,causes,,mitomycin C,,,,urethral stricture,,,,, +9485346,2161,,causes,,mitomycin C,,,,neoplasm,,,,, +26017044,2162,,affects,,mitomycin C,,,,squamous cell carcinoma,,,,, +25924198,2163,,affects,,mitomycin C,,,,adenocarcinoma,,,,, +24961205,2164,,affects,,mitomycin C,,,,neoplasm,,,,, +21183193,2165,,affects,,mitomycin C,,,,transitional cell carcinoma,,,,, +20995393,2166,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, +20865956,2167,,affects,,mitomycin C,,,,pterygium,,,,, +17166086,2168,,affects,,mitomycin C,,,,mesothelioma,,,,, +15342296,2169,,affects,,mitomycin C,,,,sclerosing cholangitis,,,,, +14897135,2170,,affects,,mitomycin C,,,,Corneal opacity,,,,, +14480408,2171,,affects,,mitomycin C,,,,liver and intrahepatic bile duct neoplasm,,,,, +14435862,2172,,affects,,mitomycin C,,,,Corneal opacity,,,,, +10146530,2173,,affects,,mitomycin C,,,,open-angle glaucoma,,,,, +8885108,2174,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, +8612675,2175,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8242643,2176,,affects,,mitomycin C,,,,neoplasm,,,,, +8428809,2177,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +26926271,2178,,disrupts,,mitomycin C,,,,Neoplasm Metastasis,,,,, +21172443,2179,,disrupts,,mitomycin C,,,,urinary bladder neoplasm,,,,, +16608751,2180,,disrupts,,mitomycin C,,,,carcinoma,,,,, +12093037,2181,,disrupts,,mitomycin C,,,,neoplasm,,,,, +8920186,2182,,disrupts,,mitomycin C,,,,Corneal opacity,,,,, +22973529,2183,,prevents,,mitomycin C,,,,glaucoma,,,,, +19902018,2184,,prevents,,mitomycin C,,,,keratoconus,,,,, +19673685,2185,,prevents,,mitomycin C,,,,urethral stricture,,,,, +12959208,2186,,prevents,,mitomycin C,,,,Neoplasm Metastasis,,,,, +11642092,2187,,prevents,,mitomycin C,,,,Esophageal stenosis,,,,, +9925117,2188,,prevents,,mitomycin C,,,,neoplasm,,,,, +8410588,2189,,prevents,,mitomycin C,,,,pterygium,,,,, +7308263,2190,,prevents,,mitomycin C,,,,urinary bladder neoplasm,,,,, +20886584,2191,,predisposes,,mitomycin C,,,,neoplasm,,,,, +17638153,2192,,related to,,Cefazolin,,,,bone fracture,,,,, +20958121,2193,,causes,,Cefazolin,,,,bacterial infectious disease with sepsis,,,,, +25339548,2194,,affects,,Cefazolin,,,,obesity disorder,,,,, +27670629,2195,,prevents,,Cefazolin,,,,staphylococcal infection,,,,, +10537097,2196,,prevents,,Cefazolin,,,,bacterial infectious disease,,,,, +7415834,2197,,affects,,Famciclovir,,,,herpes zoster,,,,, +27310156,2198,,disrupts,,Famciclovir,,,,viral infectious disease,,,,, +11859744,2199,,disrupts,,Famciclovir,,,,herpes simplex infectious disease,,,,, +11859743,2200,,disrupts,,Famciclovir,,,,genital herpes,,,,, +7415831,2201,,prevents,,Famciclovir,,,,herpes zoster,,,,, +27248580,2202,,related to,,Acyclovir,,,,herpes zoster,,,,, +20916830,2203,,causes,,Acyclovir,,,,viral infectious disease,,,,, +21459205,2204,,affects,,Acyclovir,,,,herpes zoster,,,,, +17108497,2205,,affects,,Acyclovir,,,,genital herpes,,,,, +15677184,2206,,affects,,Acyclovir,,,,viral infectious disease,,,,, +9966648,2207,,affects,,Acyclovir,,,,chickenpox,,,,, +8137898,2208,,affects,,Acyclovir,,,,cytomegalovirus infection,,,,, +26100053,2209,,disrupts,,Acyclovir,,,,herpes zoster,,,,, +21196251,2210,,disrupts,,Acyclovir,,,,cytomegalovirus infection,,,,, +21045605,2211,,disrupts,,Acyclovir,,,,herpes simplex infectious disease,,,,, +13979845,2212,,disrupts,,Acyclovir,,,,HIV infectious disease,,,,, +11163493,2213,,disrupts,,Acyclovir,,,,chickenpox,,,,, +10081763,2214,,disrupts,,Acyclovir,,,,viral infectious disease,,,,, +8112053,2215,,disrupts,,Acyclovir,,,,genital herpes,,,,, +22220716,2216,,prevents,,Acyclovir,,,,chickenpox,,,,, +14453930,2217,,prevents,,Acyclovir,,,,herpes zoster,,,,, +11048138,2218,,prevents,,Acyclovir,,,,herpes labialis,,,,, +10652424,2219,,prevents,,Acyclovir,,,,viral infectious disease,,,,, +9977810,2220,,prevents,,Acyclovir,,,,genital herpes,,,,, +8973083,2221,,prevents,,Acyclovir,,,,cytomegalovirus infection,,,,, +8455850,2222,,prevents,,Acyclovir,,,,herpes simplex infectious disease,,,,, +16777411,2223,,predisposes,,Acyclovir,,,,herpes simplex infectious disease,,,,, +14602481,2224,,predisposes,,Acyclovir,,,,HIV infectious disease,,,,, +7066348,2225,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +7066348,2226,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +10786366,2227,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +10786366,2228,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +15969143,2229,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +15969143,2230,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +10765452,2231,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +8193345,2232,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +13332148,2233,,causes,,Idoxuridine,,,,viral infectious disease,,,,, +25762983,2234,,affects,,Idoxuridine,,,,viral infectious disease,,,,, +25024576,2235,,affects,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +25798138,2236,,affects,,Vidarabine,,,,herpes simplex infectious disease,,,,, +18005400,2237,,related to,,Ganciclovir,,,,AIDS,,,,, +11769089,2238,,related to,,Ganciclovir,,,,lymphoma,,,,, +7813894,2239,,causes,,Ganciclovir,,,,hepatocellular carcinoma,,,,, +21315977,2240,,affects,,Ganciclovir,,,,melanoma,,,,, +18696617,2241,,affects,,Ganciclovir,,,,viral infectious disease,,,,, +14018850,2242,,affects,,Ganciclovir,,,,graft versus host disease,,,,, +7745805,2243,,affects,,Ganciclovir,,,,hepatocellular carcinoma,,,,, +7264703,2244,,affects,,Ganciclovir,,,,retinitis,,,,, +7193112,2245,,affects,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, +27515973,2246,,disrupts,,Ganciclovir,,,,viral infectious disease,,,,, +20042666,2247,,disrupts,,Ganciclovir,,,,glioblastoma,,,,, +11829393,2248,,disrupts,,Ganciclovir,,,,cytomegalovirus infection,,,,, +9242712,2249,,disrupts,,Ganciclovir,,,,hepatocellular carcinoma,,,,, +27273103,2250,,prevents,,Ganciclovir,,,,retinitis,,,,, +14947813,2251,,prevents,,Ganciclovir,,,,viral infectious disease,,,,, +8898867,2252,,prevents,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, +7606615,2253,,prevents,,Ganciclovir,,,,cytomegalovirus infection,,,,, +26756507,2254,,affects,,Nedocromil,,,,asthma,,,,, +12807968,2255,,affects,,Nedocromil,,,,asthma,,,,, +15773495,2256,,disrupts,,Nedocromil,,,,asthma,,,,, +26602335,2257,,prevents,,Nedocromil,,,,asthma,,,,, +25857910,2258,,related to,,Flumedroxone,,,,migraine disorder,,,,, +26456255,2259,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, +26456255,2260,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, +26331358,2261,,affects,,Valrubicin,,,,Deoxyribonucleic acid,,,,, +9013591,2262,,affects,,Valrubicin,,,,neoplasm,,,,, +15048973,2263,,disrupts,,Valrubicin,,,,neoplasm,,,,, +19780799,2264,,related to,,Idarubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +19123529,2265,,related to,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, +17160344,2266,,related to,,Idarubicin,,,,myelodysplastic syndrome,,,,, +13481436,2267,,related to,,Idarubicin,,,,acute myeloid leukemia,,,,, +12261572,2268,,related to,,Idarubicin,,,,plasma cell myeloma,,,,, +10347974,2269,,related to,,Idarubicin,,,,non-Hodgkin lymphoma,,,,, +8798925,2270,,related to,,Idarubicin,,,,acute promyelocytic leukemia,,,,, +17955637,2271,,causes,,Idarubicin,,,,acute myeloid leukemia,,,,, +10037923,2272,,causes,,Idarubicin,,,,neutropenia,,,,, +27637811,2273,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, +27582612,2274,,affects,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, +27363552,2275,,affects,,Idarubicin,,,,neoplasm,,,,, +10133635,2276,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, +9755321,2277,,affects,,Idarubicin,,,,leukemia,,,,, +9560678,2278,,affects,,Idarubicin,,,,neoplasm,,,,, +9242996,2279,,affects,,Idarubicin,,,,neutropenia,,,,, +18342294,2280,,causes,,Pirarubicin,,,,neoplasm,,,,, +16182034,2281,,affects,,Pirarubicin,,,,neoplasm,,,,, +19153993,2282,,disrupts,,Pirarubicin,,,,neoplasm,,,,, +14778803,2283,,prevents,,Pirarubicin,,,,neoplasm,,,,, +20218174,2284,,subclass of,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, +25737166,2285,,related to,,Mitoxantrone,,,,lymphoma,,,,, +19961419,2286,,related to,,Mitoxantrone,,,,breast neoplasm,,,,, +14217137,2287,,related to,,Mitoxantrone,,,,mantle cell lymphoma,,,,, +13051364,2288,,related to,,Mitoxantrone,,,,multiple sclerosis,,,,, +8903075,2289,,related to,,Mitoxantrone,,,,acute myeloid leukemia,,,,, +8584278,2290,,causes,,Mitoxantrone,,,,acute myeloid leukemia,,,,, +26143277,2291,,affects,,Mitoxantrone,,,,lymphoma,,,,, +20218175,2292,,affects,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, +11986455,2293,,affects,,Mitoxantrone,,,,multiple sclerosis,,,,, +9134230,2294,,prevents,,Mitoxantrone,,,,neoplasm,,,,, +11307631,2295,,exacerbates,,Mitoxantrone,,,,multiple sclerosis,,,,, +26844498,2296,,related to,,Doxorubicin,,,,renal cell carcinoma,,,,, +26506763,2297,,related to,,Doxorubicin,,,,Kaposi's sarcoma,,,,, +26097255,2298,,related to,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +25468576,2299,,related to,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, +21586070,2300,,related to,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, +17293414,2301,,related to,,Doxorubicin,,,,neoplasm,,,,, +14824461,2302,,related to,,Doxorubicin,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +12975330,2303,,related to,,Doxorubicin,,,,"Lymphoma, AIDS-Related",,,,, +12635005,2304,,related to,,Doxorubicin,,,,neuroendocrine neoplasm,,,,, +11664648,2305,,related to,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, +8248824,2306,,related to,,Doxorubicin,,,,lymphoma,,,,, +7897058,2307,,related to,,Doxorubicin,,,,leukemia,,,,, +7111309,2308,,related to,,Doxorubicin,,,,Hodgkins lymphoma,,,,, +26198671,2309,,causes,,Doxorubicin,,,,acute myeloid leukemia,,,,, +20905498,2310,,causes,,Doxorubicin,,,,prostate cancer,,,,, +19998968,2311,,causes,,Doxorubicin,,,,Hodgkins lymphoma,,,,, +17176693,2312,,causes,,Doxorubicin,,,,B-cell neoplasm,,,,, +16306119,2313,,causes,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +14936910,2314,,causes,,Doxorubicin,,,,plasma cell myeloma,,,,, +13613509,2315,,causes,,Doxorubicin,,,,sarcoma,,,,, +12176485,2316,,causes,,Doxorubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +12086573,2317,,causes,,Doxorubicin,,,,leukemia,,,,, +11480674,2318,,causes,,Doxorubicin,,,,Neoplasm Metastasis,,,,, +11088747,2319,,causes,,Doxorubicin,,,,neoplasm,,,,, +7374660,2320,,causes,,Doxorubicin,,,,neutropenia,,,,, +25410483,2321,,affects,,Doxorubicin,,,,glioma,,,,, +25202161,2322,,affects,,Doxorubicin,,,,glioblastoma,,,,, +24066270,2323,,affects,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, +23980169,2324,,affects,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, +20976248,2325,,affects,,Doxorubicin,,,,neuroblastoma,,,,, +20526631,2326,,affects,,Doxorubicin,,,,gastric neoplasm,,,,, +20464122,2327,,affects,,Doxorubicin,,,,T-cell non-Hodgkin lymphoma,,,,, +19907850,2328,,affects,,Doxorubicin,,,,renal cell carcinoma,,,,, +18966824,2329,,affects,,Doxorubicin,,,,leiomyosarcoma,,,,, +18841320,2330,,affects,,Doxorubicin,,,,B-cell chronic lymphocytic leukemia,,,,, +17410518,2331,,affects,,Doxorubicin,,,,rhabdomyosarcoma,,,,, +17166104,2332,,affects,,Doxorubicin,,,,mesothelioma,,,,, +17156749,2333,,affects,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, +17092174,2334,,affects,,Doxorubicin,,,,glioma,,,,, +16319458,2335,,affects,,Doxorubicin,,,,sarcoma,,,,, +15641121,2336,,affects,,Doxorubicin,,,,liver and intrahepatic bile duct neoplasm,,,,, +15592048,2337,,affects,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, +15335028,2338,,affects,,Doxorubicin,,,,pancreatic ductal adenocarcinoma,,,,, +15288278,2339,,affects,,Doxorubicin,,,,mantle cell lymphoma,,,,, +15233880,2340,,affects,,Doxorubicin,,,,prostate cancer,,,,, +14862593,2341,,affects,,Doxorubicin,,,,liposarcoma,,,,, +13717435,2342,,affects,,Doxorubicin,,,,prostate cancer,,,,, +13641465,2343,,affects,,Doxorubicin,,,,Ewing sarcoma,,,,, +13641464,2344,,affects,,Doxorubicin,,,,bone osteosarcoma,,,,, +13477582,2345,,affects,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +12593977,2346,,affects,,Doxorubicin,,,,Kaposi's sarcoma,,,,, +12038917,2347,,affects,,Doxorubicin,,,,acute lymphoblastic leukemia,,,,, +11963770,2348,,affects,,Doxorubicin,,,,angiosarcoma,,,,, +11068243,2349,,affects,,Doxorubicin,,,,neutropenia,,,,, +9029101,2350,,affects,,Doxorubicin,,,,neoplasm,,,,, +7957058,2351,,affects,,Doxorubicin,,,,neoplasm,,,,, +7468708,2352,,affects,,Doxorubicin,,,,carcinoma,,,,, +7221748,2353,,affects,,Doxorubicin,,,,small cell lung carcinoma,,,,, +22415368,2354,,disrupts,,Doxorubicin,,,,glioma,,,,, +21775806,2355,,disrupts,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, +19908932,2356,,disrupts,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, +19216444,2357,,disrupts,,Doxorubicin,,,,lymphoma,,,,, +18593046,2358,,disrupts,,Doxorubicin,,,,bone osteosarcoma,,,,, +17338969,2359,,disrupts,,Doxorubicin,,,,melanoma,,,,, +15233882,2360,,disrupts,,Doxorubicin,,,,prostate cancer,,,,, +15026936,2361,,disrupts,,Doxorubicin,,,,B-cell neoplasm,,,,, +14123664,2362,,disrupts,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +11529496,2363,,disrupts,,Doxorubicin,,,,neuroblastoma,,,,, +8800155,2364,,disrupts,,Doxorubicin,,,,neoplasm,,,,, +8316270,2365,,disrupts,,Doxorubicin,,,,Neoplasm Metastasis,,,,, +24403937,2366,,prevents,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, +23195923,2367,,prevents,,Doxorubicin,,,,lung neoplasm,,,,, +22365593,2368,,prevents,,Doxorubicin,,,,leukemia,,,,, +15227703,2369,,prevents,,Doxorubicin,,,,sarcoma,,,,, +10708896,2370,,prevents,,Doxorubicin,,,,urinary bladder neoplasm,,,,, +8872024,2371,,prevents,,Doxorubicin,,,,Neoplasm Metastasis,,,,, +8737011,2372,,prevents,,Doxorubicin,,,,neutropenia,,,,, +7721507,2373,,prevents,,Doxorubicin,,,,neoplasm,,,,, +18908502,2374,,exacerbates,,Doxorubicin,,,,neoplasm,,,,, +25000938,2375,,predisposes,,Doxorubicin,,,,bone osteosarcoma,,,,, +20426915,2376,,predisposes,,Doxorubicin,,,,neoplasm,,,,, +19669792,2377,,predisposes,,Doxorubicin,,,,sarcoma,,,,, +18137816,2378,,predisposes,,Doxorubicin,,,,lymphoma,,,,, +12722667,2379,,predisposes,,Doxorubicin,,,,acute myeloid leukemia,,,,, +8803332,2380,,predisposes,,Doxorubicin,,,,kidney Wilms tumor,,,,, +7173827,2381,,predisposes,,Doxorubicin,,,,leukemia,,,,, +26966260,2382,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, +26966260,2383,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, +10565399,2384,,physically interacts with,,Iproniazid,,,,Monoamine Oxidase,,,,, +12902070,2385,,affects,,Iproniazid,,,,depressive disorder,,,,, +9833655,2386,,affects,,Iproniazid,,,,Monoamine Oxidase,,,,, +10498318,2387,,related to,,Epirubicin,,,,non-small cell lung carcinoma,,,,, +10228088,2388,,related to,,Epirubicin,,,,ovarian cancer,,,,, +10182077,2389,,related to,,Epirubicin,,,,non-Hodgkin lymphoma,,,,, +10182076,2390,,related to,,Epirubicin,,,,Hodgkins lymphoma,,,,, +8413603,2391,,related to,,Epirubicin,,,,small cell lung carcinoma,,,,, +7746533,2392,,related to,,Epirubicin,,,,castration-resistant prostate carcinoma,,,,, +26737878,2393,,physically interacts with,,Epirubicin,,,,7-Deoxydoxorubicinone,,,,, +18781215,2394,,causes,,Epirubicin,,,,neoplasm,,,,, +26736958,2395,,affects,,Epirubicin,,,,hepatocellular carcinoma,,,,, +12104701,2396,,affects,,Epirubicin,,,,neoplasm,,,,, +14784473,2397,,prevents,,Epirubicin,,,,neoplasm,,,,, +10544897,2398,,physically interacts with,,Nialamide,,,,Monoamine Oxidase,,,,, +9388429,2399,,affects,,Nialamide,,,,Monoamine Oxidase,,,,, +10646811,2400,,affects,,Isocarboxazid,,,,Monoamine Oxidase,,,,, +14451724,2401,,causes,,Valacyclovir,,,,psychotic disorder,,,,, +27205274,2402,,affects,,Valacyclovir,,,,postherpetic neuralgia,,,,, +25557382,2403,,affects,,Valacyclovir,,,,Pregnancy,,,,, +19384061,2404,,disrupts,,Valacyclovir,,,,herpes simplex infectious disease,,,,, +14963245,2405,,disrupts,,Valacyclovir,,,,herpes zoster,,,,, +10778326,2406,,disrupts,,Valacyclovir,,,,viral infectious disease,,,,, +10108851,2407,,disrupts,,Valacyclovir,,,,herpes labialis,,,,, +8112054,2408,,disrupts,,Valacyclovir,,,,genital herpes,,,,, +19368060,2409,,prevents,,Valacyclovir,,,,postherpetic neuralgia,,,,, +12346968,2410,,prevents,,Valacyclovir,,,,genital herpes,,,,, +10108849,2411,,prevents,,Valacyclovir,,,,herpes labialis,,,,, +9970234,2412,,prevents,,Valacyclovir,,,,herpes simplex infectious disease,,,,, +8018684,2413,,prevents,,Valacyclovir,,,,cytomegalovirus infection,,,,, +8899981,2414,,affects,,Cidofovir,,,,cytomegalovirus retinitis,,,,, +7346321,2415,,affects,,Cidofovir,,,,viral infectious disease,,,,, +11567412,2416,,disrupts,,Cidofovir,,,,cytomegalovirus infection,,,,, +27502123,2417,,prevents,,Cidofovir,,,,herpes simplex infectious disease,,,,, +16212718,2418,,prevents,,Cidofovir,,,,cytomegalovirus infection,,,,, +11248462,2419,,prevents,,Cidofovir,,,,viral infectious disease,,,,, +26922185,2420,,affects,,Penciclovir,,,,viral infectious disease,,,,, +22087736,2421,,affects,,Valganciclovir,,,,cytomegalovirus infection,,,,, +18756429,2422,,affects,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, +20121657,2423,,disrupts,,Valganciclovir,,,,cytomegalovirus infection,,,,, +12085189,2424,,prevents,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, +11282399,2425,,prevents,,Valganciclovir,,,,cytomegalovirus infection,,,,, +23156448,2426,,predisposes,,Valganciclovir,,,,kidney disorder,,,,, +20121656,2427,,predisposes,,Valganciclovir,,,,cytomegalovirus infection,,,,, +24607675,2428,,prevents,,Remdesivir,,,,adult acute respiratory distress syndrome,,,,, +18302878,2429,,related to,,Pixantrone,,,,Deoxyribonucleic acid,,,,, +19964229,2430,,affects,,Amrubicin,,,,small cell lung carcinoma,,,,, +15413207,2431,,disrupts,,Amrubicin,,,,neoplasm,,,,, +16523835,2432,,related to,,Sevoflurane,,,,delirium,,,,, +24969850,2433,,causes,,Sevoflurane,,,,adult acute respiratory distress syndrome,,,,, +24682900,2434,,causes,,Sevoflurane,,,,acute kidney failure,,,,, +18232524,2435,,causes,,Sevoflurane,,,,Inflammation,,,,, +17508909,2436,,causes,,Sevoflurane,,,,brain injury,,,,, +17459839,2437,,causes,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +11419059,2438,,causes,,Sevoflurane,,,,delirium,,,,, +7326848,2439,,causes,,Sevoflurane,,,,Pain,,,,, +25308865,2440,,affects,,Sevoflurane,,,,neoplasm,,,,, +25006055,2441,,affects,,Sevoflurane,,,,Pain,,,,, +21710900,2442,,affects,,Sevoflurane,,,,obesity disorder,,,,, +18602416,2443,,affects,,Sevoflurane,,,,delirium,,,,, +17685948,2444,,affects,,Sevoflurane,,,,Pain,,,,, +17508906,2445,,affects,,Sevoflurane,,,,brain injury,,,,, +13563816,2446,,affects,,Sevoflurane,,,,Inflammation,,,,, +7303814,2447,,affects,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +22571416,2448,,disrupts,,Sevoflurane,,,,myocardial infarction,,,,, +22138617,2449,,disrupts,,Sevoflurane,,,,brain injury,,,,, +19949689,2450,,disrupts,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +17977822,2451,,disrupts,,Sevoflurane,,,,Inflammation,,,,, +24348187,2452,,prevents,,Sevoflurane,,,,acute kidney failure,,,,, +24204877,2453,,prevents,,Sevoflurane,,,,neoplasm,,,,, +20028749,2454,,prevents,,Sevoflurane,,,,delirium,,,,, +19290567,2455,,prevents,,Sevoflurane,,,,Pain,,,,, +16830216,2456,,prevents,,Sevoflurane,,,,Inflammation,,,,, +11671117,2457,,prevents,,Sevoflurane,,,,brain injury,,,,, +9664903,2458,,prevents,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +18320093,2459,,predisposes,,Sevoflurane,,,,delirium,,,,, +18121347,2460,,predisposes,,Sevoflurane,,,,Inflammation,,,,, +24455592,2461,,causes,,Desflurane,,,,Postoperative Complications,,,,, +16095968,2462,,related to,,Heroin,,,,heroin dependence,,,,, +9440915,2463,,related to,,Heroin,,,,opiate dependence,,,,, +18531996,2464,,causes,,Heroin,,,,heroin dependence,,,,, +14784390,2465,,causes,,Heroin,,,,opiate dependence,,,,, +19449218,2466,,related to,,Aluminum hydroxide,,,,type 1 diabetes mellitus,,,,, +19135529,2467,,related to,,Aluminum hydroxide,,,,malaria,,,,, +18758930,2468,,related to,,Aluminum hydroxide,,,,influenza,,,,, +15398111,2469,,prevents,,Aluminum hydroxide,,,,stomatitis,,,,, +15812884,2470,,related to,,Methadone,,,,heroin dependence,,,,, +19260564,2471,,causes,,Methadone,,,,neonatal abstinence syndrome,,,,, +18130331,2472,,causes,,Methadone,,,,neuralgia,,,,, +18100345,2473,,causes,,Methadone,,,,Pain,,,,, +21405277,2474,,affects,,Methadone,,,,opiate dependence,,,,, +21075382,2475,,affects,,Methadone,,,,neoplasm,,,,, +20010980,2476,,affects,,Methadone,,,,Premature birth,,,,, +18302283,2477,,affects,,Methadone,,,,Pain,,,,, +18207522,2478,,affects,,Methadone,,,,neonatal abstinence syndrome,,,,, +18078354,2479,,affects,,Methadone,,,,cocaine dependence,,,,, +11558529,2480,,affects,,Methadone,,,,HIV infectious disease,,,,, +9289228,2481,,affects,,Methadone,,,,HIV infectious disease,,,,, +8979183,2482,,affects,,Methadone,,,,neuralgia,,,,, +16059875,2483,,disrupts,,Methadone,,,,neonatal abstinence syndrome,,,,, +10769844,2484,,disrupts,,Methadone,,,,Pain,,,,, +17766557,2485,,prevents,,Methadone,,,,hepatitis C virus infection,,,,, +15264750,2486,,prevents,,Methadone,,,,opiate dependence,,,,, +8905283,2487,,prevents,,Methadone,,,,Pain,,,,, +8022918,2488,,prevents,,Methadone,,,,neonatal abstinence syndrome,,,,, +26487110,2489,,predisposes,,Methadone,,,,HIV infectious disease,,,,, +15424591,2490,,predisposes,,Methadone,,,,neonatal abstinence syndrome,,,,, +14491460,2491,,predisposes,,Methadone,,,,Premature birth,,,,, +26386166,2492,,causes,,Levomethadyl acetate,,,,opiate dependence,,,,, +26901861,2493,,prevents,,Halofantrine,,,,malaria,,,,, +27668107,2494,,related to,,Erythropoietin,,,,HIV infectious disease,,,,, +24695634,2495,,related to,,Erythropoietin,,,,optic nerve disorder,,,,, +21186290,2496,,related to,,Erythropoietin,,,,Premature birth,,,,, +20871066,2497,,related to,,Erythropoietin,,,,necrotizing enterocolitis,,,,, +18130124,2498,,related to,,Erythropoietin,,,,mood disorder,,,,, +17186873,2499,,related to,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, +16980950,2500,,related to,,Erythropoietin,,,,acute myeloid leukemia,,,,, +16468663,2501,,related to,,Erythropoietin,,,,optic neuritis,,,,, +16173384,2502,,related to,,Erythropoietin,,,,Friedreich ataxia,,,,, +15054484,2503,,related to,,Erythropoietin,,,,breast neoplasm,,,,, +14004775,2504,,related to,,Erythropoietin,,,,malaria,,,,, +13955435,2505,,related to,,Erythropoietin,,,,chronic renal failure syndrome,,,,, +13624052,2506,,related to,,Erythropoietin,,,,stroke disorder,,,,, +13580694,2507,,related to,,Erythropoietin,,,,Fatigue,,,,, +13206114,2508,,related to,,Erythropoietin,,,,sickle cell anemia,,,,, +12496787,2509,,related to,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, +12188394,2510,,related to,,Erythropoietin,,,,Parkinson disease,,,,, +12126135,2511,,related to,,Erythropoietin,,,,spinal cord injury,,,,, +11923140,2512,,related to,,Erythropoietin,,,,acute kidney failure,,,,, +11799479,2513,,related to,,Erythropoietin,,,,myocardial infarction,,,,, +11734187,2514,,related to,,Erythropoietin,,,,multiple sclerosis,,,,, +11580074,2515,,related to,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +11529882,2516,,related to,,Erythropoietin,,,,myocardial ischemia,,,,, +11452051,2517,,related to,,Erythropoietin,,,,prostate cancer,,,,, +11316441,2518,,related to,,Erythropoietin,,,,Ischemic stroke,,,,, +11293850,2519,,related to,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, +10879812,2520,,related to,,Erythropoietin,,,,hepatitis C virus infection,,,,, +10348029,2521,,related to,,Erythropoietin,,,,neoplasm,,,,, +9392178,2522,,related to,,Erythropoietin,,,,injury,,,,, +9089666,2523,,related to,,Erythropoietin,,,,chronic myelomonocytic leukemia,,,,, +8164061,2524,,related to,,Erythropoietin,,,,myelodysplastic syndrome,,,,, +7458321,2525,,related to,,Erythropoietin,,,,brain ischemia,,,,, +7310369,2526,,related to,,Erythropoietin,,,,anemia,,,,, +7231907,2527,,related to,,Erythropoietin,,,,chronic kidney disease,,,,, +7137476,2528,,related to,,Erythropoietin,,,,kidney failure,,,,, +12479345,2529,,has part,,Erythropoietin,,,,myelodysplastic syndrome,,,,, +9398172,2530,,has part,,Erythropoietin,,,,neoplasm,,,,, +27259307,2531,,causes,,Erythropoietin,,,,acute kidney failure,,,,, +20985522,2532,,causes,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +19282478,2533,,causes,,Erythropoietin,,,,neoplasm,,,,, +19178150,2534,,causes,,Erythropoietin,,,,spinal cord injury,,,,, +18508111,2535,,causes,,Erythropoietin,,,,Parkinson disease,,,,, +16355442,2536,,causes,,Erythropoietin,,,,brain ischemia,,,,, +15387266,2537,,causes,,Erythropoietin,,,,stroke disorder,,,,, +13935957,2538,,causes,,Erythropoietin,,,,injury,,,,, +12824447,2539,,causes,,Erythropoietin,,,,chronic kidney disease,,,,, +11912976,2540,,causes,,Erythropoietin,,,,myocardial infarction,,,,, +11763164,2541,,causes,,Erythropoietin,,,,Fatigue,,,,, +9672360,2542,,causes,,Erythropoietin,,,,kidney failure,,,,, +9370139,2543,,causes,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, +8009177,2544,,causes,,Erythropoietin,,,,anemia,,,,, +26962810,2545,,affects,,Erythropoietin,,,,HIV infectious disease,,,,, +26278974,2546,,affects,,Erythropoietin,,,,sickle cell anemia,,,,, +24983690,2547,,affects,,Erythropoietin,,,,acute myeloid leukemia,,,,, +20885392,2548,,affects,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, +20610677,2549,,affects,,Erythropoietin,,,,stroke disorder,,,,, +18390137,2550,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, +18352546,2551,,affects,,Erythropoietin,,,,injury,,,,, +17607901,2552,,affects,,Erythropoietin,,,,necrotizing enterocolitis,,,,, +15862945,2553,,affects,,Erythropoietin,,,,Ischemic stroke,,,,, +15862785,2554,,affects,,Erythropoietin,,,,malaria,,,,, +15728394,2555,,affects,,Erythropoietin,,,,myocardial infarction,,,,, +15532613,2556,,affects,,Erythropoietin,,,,myocardial infarction,,,,, +12937865,2557,,affects,,Erythropoietin,,,,anemia,,,,, +12867407,2558,,affects,,Erythropoietin,,,,myocardial ischemia,,,,, +11701568,2559,,affects,,Erythropoietin,,,,Fatigue,,,,, +11563361,2560,,affects,,Erythropoietin,,,,neoplasm,,,,, +10970912,2561,,affects,,Erythropoietin,,,,brain injury,,,,, +10068762,2562,,affects,,Erythropoietin,,,,injury,,,,, +9989127,2563,,affects,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +9392180,2564,,affects,,Erythropoietin,,,,spinal cord injury,,,,, +8981317,2565,,affects,,Erythropoietin,,,,brain ischemia,,,,, +7400221,2566,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, +7278560,2567,,affects,,Erythropoietin,,,,anemia,,,,, +27259305,2568,,produces,,Erythropoietin,,,,acute kidney failure,,,,, +26811591,2569,,produces,,Erythropoietin,,,,HIV infectious disease,,,,, +26231858,2570,,produces,,Erythropoietin,,,,lymphoma,,,,, +14673419,2571,,produces,,Erythropoietin,,,,myocardial infarction,,,,, +11452049,2572,,produces,,Erythropoietin,,,,prostate cancer,,,,, +8829207,2573,,produces,,Erythropoietin,,,,neoplasm,,,,, +8032421,2574,,produces,,Erythropoietin,,,,chronic renal failure syndrome,,,,, +8032418,2575,,produces,,Erythropoietin,,,,chronic kidney disease,,,,, +7919214,2576,,produces,,Erythropoietin,,,,anemia,,,,, +7844664,2577,,produces,,Erythropoietin,,,,kidney failure,,,,, +17835656,2578,,disrupts,,Erythropoietin,,,,brain injury,,,,, +17602040,2579,,disrupts,,Erythropoietin,,,,Hemorrhage,,,,, +17384804,2580,,disrupts,,Erythropoietin,,,,Ischemic stroke,,,,, +15027834,2581,,disrupts,,Erythropoietin,,,,Fatigue,,,,, +13243471,2582,,disrupts,,Erythropoietin,,,,chronic kidney disease,,,,, +13033535,2583,,disrupts,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, +11253087,2584,,disrupts,,Erythropoietin,,,,injury,,,,, +8818732,2585,,disrupts,,Erythropoietin,,,,anemia,,,,, +22124183,2586,,prevents,,Erythropoietin,,,,Premature birth,,,,, +19522952,2587,,prevents,,Erythropoietin,,,,Asphyxia,,,,, +17246645,2588,,prevents,,Erythropoietin,,,,cerebral palsy,,,,, +16915551,2589,,prevents,,Erythropoietin,,,,coronary artery disorder,,,,, +16468664,2590,,prevents,,Erythropoietin,,,,optic neuritis,,,,, +16040441,2591,,prevents,,Erythropoietin,,,,spinal cord injury,,,,, +15444373,2592,,prevents,,Erythropoietin,,,,Parkinson disease,,,,, +14252439,2593,,prevents,,Erythropoietin,,,,kidney failure,,,,, +13347324,2594,,prevents,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, +13017739,2595,,prevents,,Erythropoietin,,,,chronic kidney disease,,,,, +11480928,2596,,prevents,,Erythropoietin,,,,Ischemic stroke,,,,, +11148609,2597,,prevents,,Erythropoietin,,,,myocardial ischemia,,,,, +11115141,2598,,prevents,,Erythropoietin,,,,stroke disorder,,,,, +10838253,2599,,prevents,,Erythropoietin,,,,necrotizing enterocolitis,,,,, +10766440,2600,,prevents,,Erythropoietin,,,,myocardial infarction,,,,, +10125087,2601,,prevents,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +8434315,2602,,prevents,,Erythropoietin,,,,injury,,,,, +8405867,2603,,prevents,,Erythropoietin,,,,brain ischemia,,,,, +8369017,2604,,prevents,,Erythropoietin,,,,brain injury,,,,, +7400218,2605,,prevents,,Erythropoietin,,,,Fatigue,,,,, +7236347,2606,,prevents,,Erythropoietin,,,,anemia,,,,, +18610239,2607,,exacerbates,,Erythropoietin,,,,injury,,,,, +14126866,2608,,exacerbates,,Erythropoietin,,,,anemia,,,,, +25818939,2609,,predisposes,,Erythropoietin,,,,neoplasm,,,,, +19869298,2610,,predisposes,,Erythropoietin,,,,coronary artery disorder,,,,, +19564296,2611,,predisposes,,Erythropoietin,,,,Asphyxia,,,,, +19270398,2612,,predisposes,,Erythropoietin,,,,brain injury,,,,, +18282528,2613,,predisposes,,Erythropoietin,,,,chronic kidney disease,,,,, +16056103,2614,,predisposes,,Erythropoietin,,,,Ischemic stroke,,,,, +14483144,2615,,predisposes,,Erythropoietin,,,,injury,,,,, +12166360,2616,,predisposes,,Erythropoietin,,,,kidney failure,,,,, +8361116,2617,,predisposes,,Erythropoietin,,,,anemia,,,,, +24327196,2618,,affects,,Daprodustat,,,,anemia,,,,, +24574810,2619,,prevents,,Daprodustat,,,,anemia,,,,, +19595886,2620,,related to,,mecobalamin,,,,vitamin B12 deficiency,,,,, +13417310,2621,,related to,,mecobalamin,,,,amyotrophic lateral sclerosis,,,,, +26391120,2622,,related to,,vitamin B12,,,,myocardial infarction,,,,, +21860699,2623,,related to,,vitamin B12,,,,type 2 diabetes mellitus,,,,, +20662929,2624,,related to,,vitamin B12,,,,non-small cell lung carcinoma,,,,, +19346996,2625,,related to,,vitamin B12,,,,myocardial ischemia,,,,, +12974621,2626,,related to,,vitamin B12,,,,osteoporosis,,,,, +10934739,2627,,related to,,vitamin B12,,,,chronic kidney disease,,,,, +10883089,2628,,related to,,vitamin B12,,,,depressive disorder,,,,, +10658870,2629,,related to,,vitamin B12,,,,psoriasis,,,,, +10535786,2630,,related to,,vitamin B12,,,,atherosclerosis,,,,, +10535188,2631,,related to,,vitamin B12,,,,lymphoma,,,,, +10508686,2632,,related to,,vitamin B12,,,,vitamin B12 deficiency,,,,, +10438501,2633,,related to,,vitamin B12,,,,iron deficiency anemia,,,,, +9977774,2634,,related to,,vitamin B12,,,,psychotic disorder,,,,, +9644935,2635,,related to,,vitamin B12,,,,anemia,,,,, +9118739,2636,,related to,,vitamin B12,,,,Low back pain,,,,, +8678107,2637,,related to,,vitamin B12,,,,Alzheimer disease,,,,, +27330642,2638,,causes,,vitamin B12,,,,depressive disorder,,,,, +26003936,2639,,causes,,vitamin B12,,,,diabetic neuropathy,,,,, +17687811,2640,,causes,,vitamin B12,,,,osteoporosis,,,,, +11993792,2641,,causes,,vitamin B12,,,,Reduced blood folate concentration,,,,, +10806959,2642,,causes,,vitamin B12,,,,psychotic disorder,,,,, +10716413,2643,,causes,,vitamin B12,,,,vitamin B12 deficiency,,,,, +9828196,2644,,causes,,vitamin B12,,,,anemia,,,,, +7900732,2645,,causes,,vitamin B12,,,,atherosclerosis,,,,, +25091008,2646,,affects,,vitamin B12,,,,HIV infectious disease,,,,, +20098295,2647,,affects,,vitamin B12,,,,depressive disorder,,,,, +19763864,2648,,affects,,vitamin B12,,,,Alzheimer disease,,,,, +18490813,2649,,affects,,vitamin B12,,,,depressive disorder,,,,, +17348852,2650,,affects,,vitamin B12,,,,vitamin B12 deficiency,,,,, +16930257,2651,,affects,,vitamin B12,,,,amyotrophic lateral sclerosis,,,,, +13607058,2652,,affects,,vitamin B12,,,,depressive disorder,,,,, +12773836,2653,,affects,,vitamin B12,,,,atherosclerosis,,,,, +11945900,2654,,affects,,vitamin B12,,,,Pregnancy,,,,, +11927611,2655,,affects,,vitamin B12,,,,diabetic neuropathy,,,,, +10798681,2656,,affects,,vitamin B12,,,,type 2 diabetes mellitus,,,,, +10424959,2657,,affects,,vitamin B12,,,,anemia,,,,, +8733280,2658,,affects,,vitamin B12,,,,Pregnancy,,,,, +8015838,2659,,affects,,vitamin B12,,,,chronic kidney disease,,,,, +23636866,2660,,produces,,vitamin B12,,,,vitamin B12 deficiency,,,,, +11124683,2661,,disrupts,,vitamin B12,,,,chronic kidney disease,,,,, +20603701,2662,,prevents,,vitamin B12,,,,Alzheimer disease,,,,, +14586818,2663,,prevents,,vitamin B12,,,,anemia,,,,, +10782972,2664,,prevents,,vitamin B12,,,,atherosclerosis,,,,, +9545669,2665,,prevents,,vitamin B12,,,,vitamin B12 deficiency,,,,, +27415421,2666,,predisposes,,vitamin B12,,,,myocardial infarction,,,,, +21063265,2667,,predisposes,,vitamin B12,,,,depressive disorder,,,,, +20875915,2668,,predisposes,,vitamin B12,,,,chronic kidney disease,,,,, +15081186,2669,,predisposes,,vitamin B12,,,,osteoporosis,,,,, +12678935,2670,,predisposes,,vitamin B12,,,,atherosclerosis,,,,, +12664527,2671,,predisposes,,vitamin B12,,,,Alzheimer disease,,,,, +8590188,2672,,predisposes,,vitamin B12,,,,anemia,,,,, +22149451,2673,,affects,,Ipragliflozin,,,,type 2 diabetes mellitus,,,,, +24120079,2674,,disrupts,,Ertugliflozin,,,,diabetes mellitus,,,,, +23006843,2675,,related to,,Empagliflozin,,,,diabetes mellitus,,,,, +22183651,2676,,related to,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, +24924157,2677,,causes,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, +23515975,2678,,causes,,Empagliflozin,,,,myocardial infarction,,,,, +23240834,2679,,causes,,Empagliflozin,,,,acute kidney failure,,,,, +25094844,2680,,affects,,Empagliflozin,,,,diabetes mellitus,,,,, +24520517,2681,,affects,,Empagliflozin,,,,Insulin resistance,,,,, +24184835,2682,,affects,,Empagliflozin,,,,diabetic kidney disease,,,,, +24091231,2683,,affects,,Empagliflozin,,,,kidney disorder,,,,, +22935616,2684,,affects,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, +22175650,2685,,affects,,Empagliflozin,,,,acute kidney failure,,,,, +22027265,2686,,affects,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, +21867589,2687,,affects,,Empagliflozin,,,,myocardial infarction,,,,, +21618629,2688,,affects,,Empagliflozin,,,,pulmonary arterial hypertension,,,,, +22842915,2689,,disrupts,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, +23528682,2690,,prevents,,Empagliflozin,,,,myocardial infarction,,,,, +23286446,2691,,prevents,,Empagliflozin,,,,acute kidney failure,,,,, +24551007,2692,,predisposes,,Empagliflozin,,,,acute kidney failure,,,,, +24497752,2693,,predisposes,,Empagliflozin,,,,hypoglycemia,,,,, +23163444,2694,,predisposes,,Empagliflozin,,,,diabetic kidney disease,,,,, +21786786,2695,,related to,,Dapagliflozin,,,,Alzheimer disease,,,,, +23582915,2696,,causes,,Dapagliflozin,,,,Weight loss,,,,, +25156234,2697,,affects,,Dapagliflozin,,,,non-alcoholic fatty liver disease,,,,, +23530734,2698,,affects,,Dapagliflozin,,,,Albuminuria,,,,, +23107287,2699,,affects,,Dapagliflozin,,,,type 1 diabetes mellitus,,,,, +23072376,2700,,affects,,Dapagliflozin,,,,ischemia reperfusion injury,,,,, +22916804,2701,,affects,,Dapagliflozin,,,,diabetic kidney disease,,,,, +22845588,2702,,affects,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, +22578057,2703,,affects,,Dapagliflozin,,,,Albuminuria,,,,, +22163310,2704,,affects,,Dapagliflozin,,,,Weight loss,,,,, +21622453,2705,,affects,,Dapagliflozin,,,,atrial fibrillation,,,,, +25362847,2706,,disrupts,,Dapagliflozin,,,,acute kidney failure,,,,, +23258105,2707,,disrupts,,Dapagliflozin,,,,kidney failure,,,,, +22845589,2708,,disrupts,,Dapagliflozin,,,,diabetes mellitus,,,,, +23973238,2709,,prevents,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, +23528684,2710,,prevents,,Dapagliflozin,,,,myocardial infarction,,,,, +23138841,2711,,prevents,,Dapagliflozin,,,,diabetic kidney disease,,,,, +22845590,2712,,prevents,,Dapagliflozin,,,,diabetes mellitus,,,,, +22832530,2713,,prevents,,Dapagliflozin,,,,kidney failure,,,,, +21513723,2714,,prevents,,Dapagliflozin,,,,obesity disorder,,,,, +25236689,2715,,predisposes,,Dapagliflozin,,,,kidney failure,,,,, +23072379,2716,,predisposes,,Dapagliflozin,,,,myocardial infarction,,,,, +20833370,2717,,related to,,Methyldopa,,,,type 1 diabetes mellitus,,,,, +15433400,2718,,related to,,Methyldopa,,,,preeclampsia,,,,, +7364754,2719,,related to,,Methyldopa,,,,hypertensive disorder,,,,, +25805913,2720,,causes,,Methyldopa,,,,hypertensive disorder,,,,, +23430063,2721,,causes,,Methyldopa,,,,preeclampsia,,,,, +26257846,2722,,affects,,Methyldopa,,,,hypertensive disorder,,,,, +10671192,2723,,affects,,Methyldopa,,,,hypertensive disorder,,,,, +26170425,2724,,prevents,,Methyldopa,,,,hypertensive disorder,,,,, +8219214,2725,,exacerbates,,Methyldopa,,,,hypertensive disorder,,,,, +20611289,2726,,predisposes,,Methyldopa,,,,preeclampsia,,,,, +19343164,2727,,related to,,Exemestane,,,,male breast carcinoma,,,,, +14849934,2728,,related to,,Exemestane,,,,ductal breast carcinoma in situ,,,,, +14694867,2729,,related to,,Exemestane,,,,non-small cell lung carcinoma,,,,, +11511167,2730,,related to,,Exemestane,,,,neoplasm,,,,, +18732584,2731,,affects,,Exemestane,,,,neoplasm,,,,, +14063167,2732,,affects,,Exemestane,,,,neoplasm,,,,, +16053578,2733,,prevents,,Exemestane,,,,breast neoplasm,,,,, +20235097,2734,,disrupts,,Rivizor,,,,neoplasm,,,,, +24226617,2735,,related to,,Letrozole,,,,polycystic ovary syndrome,,,,, +19925368,2736,,related to,,Letrozole,,,,infertility disorder,,,,, +13004646,2737,,related to,,Letrozole,,,,endometriosis,,,,, +11511165,2738,,related to,,Letrozole,,,,neoplasm,,,,, +22485512,2739,,causes,,Letrozole,,,,infertility disorder,,,,, +17708157,2740,,causes,,Letrozole,,,,neoplasm,,,,, +14659251,2741,,causes,,Letrozole,,,,endometriosis,,,,, +11078418,2742,,causes,,Letrozole,,,,polycystic ovary syndrome,,,,, +10282160,2743,,causes,,Letrozole,,,,hypogonadism,,,,, +25205942,2744,,affects,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, +18870552,2745,,affects,,Letrozole,,,,Pregnancy,,,,, +18835925,2746,,affects,,Letrozole,,,,inflammatory breast carcinoma,,,,, +10866444,2747,,affects,,Letrozole,,,,Pregnancy,,,,, +7871182,2748,,affects,,Letrozole,,,,neoplasm,,,,, +21352213,2749,,disrupts,,Letrozole,,,,Pregnancy,,,,, +25448977,2750,,prevents,,Letrozole,,,,prostate cancer,,,,, +19305611,2751,,prevents,,Letrozole,,,,Spontaneous abortion,,,,, +17892609,2752,,prevents,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, +13373696,2753,,prevents,,Letrozole,,,,neoplasm,,,,, +20363763,2754,,predisposes,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, +19305612,2755,,predisposes,,Letrozole,,,,Spontaneous abortion,,,,, +26765214,2756,,affects,,Formestane,,,,neoplasm,,,,, +25526748,2757,,disrupts,,Formestane,,,,neoplasm,,,,, +13022860,2758,,prevents,,Formestane,,,,neoplasm,,,,, +26325498,2759,,affects,,Aminoglutethimide,,,,neoplasm,,,,, +12185634,2760,,affects,,Aminoglutethimide,,,,neoplasm,,,,, +22275813,2761,,related to,,Relugolix,,,,prostate cancer,,,,, +23469407,2762,,prevents,,Relugolix,,,,Pain,,,,, +25422975,2763,,related to,,Abiraterone,,,,castration-resistant prostate carcinoma,,,,, +20717678,2764,,related to,,Abiraterone,,,,prostate cancer,,,,, +16721978,2765,,affects,,Abiraterone,,,,prostate cancer,,,,, +15794241,2766,,prevents,,Abiraterone,,,,neoplasm,,,,, +19010753,2767,,predisposes,,Abiraterone,,,,prostate cancer,,,,, +11344546,2768,,related to,,Finasteride,,,,acne,,,,, +11344545,2769,,related to,,Finasteride,,,,alopecia,,,,, +9840638,2770,,related to,,Finasteride,,,,prostate cancer,,,,, +7359591,2771,,related to,,Finasteride,,,,benign prostatic hyperplasia,,,,, +21759063,2772,,causes,,Finasteride,,,,benign prostatic hyperplasia,,,,, +11694493,2773,,causes,,Finasteride,,,,prostate cancer,,,,, +11326933,2774,,affects,,Finasteride,,,,prostate cancer,,,,, +9873046,2775,,affects,,Finasteride,,,,benign prostatic hyperplasia,,,,, +9845785,2776,,affects,,Finasteride,,,,alopecia,,,,, +7857572,2777,,affects,,Finasteride,,,,prostate cancer,,,,, +21155186,2778,,disrupts,,Finasteride,,,,benign prostatic hyperplasia,,,,, +10949204,2779,,disrupts,,Finasteride,,,,prostate cancer,,,,, +7931250,2780,,disrupts,,Finasteride,,,,alopecia,,,,, +11279550,2781,,prevents,,Finasteride,,,,benign prostatic hyperplasia,,,,, +8938663,2782,,prevents,,Finasteride,,,,alopecia,,,,, +7857569,2783,,prevents,,Finasteride,,,,prostate cancer,,,,, +9840634,2784,,predisposes,,Finasteride,,,,prostate cancer,,,,, +8913536,2785,,predisposes,,Finasteride,,,,benign prostatic hyperplasia,,,,, +15677403,2786,,related to,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +14665250,2787,,related to,,Dutasteride,,,,prostate cancer,,,,, +22506276,2788,,causes,,Dutasteride,,,,prostatitis,,,,, +14995448,2789,,affects,,Dutasteride,,,,prostate cancer,,,,, +11407079,2790,,affects,,Dutasteride,,,,prostatitis,,,,, +10333399,2791,,affects,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +15838005,2792,,disrupts,,Dutasteride,,,,prostate cancer,,,,, +16876475,2793,,prevents,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +13018366,2794,,prevents,,Dutasteride,,,,alopecia,,,,, +12506526,2795,,prevents,,Dutasteride,,,,prostate cancer,,,,, +13749427,2796,,predisposes,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +13628345,2797,,predisposes,,Dutasteride,,,,prostate cancer,,,,, +23122900,2798,,related to,,Celecoxib,,,,Pain,,,,, +20821764,2799,,related to,,Celecoxib,,,,prostate cancer,,,,, +14485082,2800,,related to,,Celecoxib,,,,castration-resistant prostate carcinoma,,,,, +14288130,2801,,related to,,Celecoxib,,,,neoplasm,,,,, +15210658,2802,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, +15210658,2803,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11056859,2804,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11056859,2805,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +19664582,2806,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +19664582,2807,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +8460221,2808,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +9140190,2809,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +22101111,2810,,causes,,Celecoxib,,,,Alzheimer disease,,,,, +21110777,2811,,causes,,Celecoxib,,,,schizophrenia,,,,, +20555672,2812,,causes,,Celecoxib,,,,hepatocellular carcinoma,,,,, +14478589,2813,,causes,,Celecoxib,,,,Inflammation,,,,, +14396158,2814,,causes,,Celecoxib,,,,neoplasm,,,,, +13894212,2815,,causes,,Celecoxib,,,,peptic ulcer disease,,,,, +13829410,2816,,causes,,Celecoxib,,,,Pain,,,,, +12882318,2817,,causes,,Celecoxib,,,,colorectal neoplasm,,,,, +12147702,2818,,causes,,Celecoxib,,,,osteoarthritis,,,,, +12029200,2819,,causes,,Celecoxib,,,,Hemorrhage,,,,, +10018014,2820,,causes,,Celecoxib,,,,hypertensive disorder,,,,, +25555760,2821,,affects,,Celecoxib,,,,postpartum depression,,,,, +21116356,2822,,affects,,Celecoxib,,,,major depressive disorder,,,,, +19634803,2823,,affects,,Celecoxib,,,,Hemorrhage,,,,, +18087191,2824,,affects,,Celecoxib,,,,breast neoplasm,,,,, +17669654,2825,,affects,,Celecoxib,,,,glioma,,,,, +17634409,2826,,affects,,Celecoxib,,,,depressive disorder,,,,, +16787676,2827,,affects,,Celecoxib,,,,hypertensive disorder,,,,, +15889622,2828,,affects,,Celecoxib,,,,osteoarthritis,,,,, +13667242,2829,,affects,,Celecoxib,,,,obesity disorder,,,,, +13414910,2830,,affects,,Celecoxib,,,,Hemorrhage,,,,, +13122831,2831,,affects,,Celecoxib,,,,hypertensive disorder,,,,, +12419082,2832,,affects,,Celecoxib,,,,neoplasm,,,,, +11947530,2833,,affects,,Celecoxib,,,,hepatocellular carcinoma,,,,, +11444192,2834,,affects,,Celecoxib,,,,neoplasm,,,,, +11303331,2835,,affects,,Celecoxib,,,,non-small cell lung carcinoma,,,,, +10337670,2836,,affects,,Celecoxib,,,,colorectal neoplasm,,,,, +10157341,2837,,affects,,Celecoxib,,,,injury,,,,, +9967873,2838,,affects,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +9574485,2839,,affects,,Celecoxib,,,,schizophrenia,,,,, +9038473,2840,,affects,,Celecoxib,,,,peptic ulcer disease,,,,, +7841958,2841,,affects,,Celecoxib,,,,rheumatoid arthritis,,,,, +7726669,2842,,affects,,Celecoxib,,,,Pain,,,,, +7726668,2843,,affects,,Celecoxib,,,,Inflammation,,,,, +7264055,2844,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11464194,2845,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11846592,2846,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11846592,2847,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, +14865798,2848,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, +14865798,2849,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, +22029254,2850,,disrupts,,Celecoxib,,,,major depressive disorder,,,,, +16862201,2851,,disrupts,,Celecoxib,,,,hepatocellular carcinoma,,,,, +15337601,2852,,disrupts,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +15029907,2853,,disrupts,,Celecoxib,,,,Pain,,,,, +14234726,2854,,disrupts,,Celecoxib,,,,adenoma,,,,, +12025752,2855,,disrupts,,Celecoxib,,,,colonic neoplasm,,,,, +9589598,2856,,disrupts,,Celecoxib,,,,neoplasm,,,,, +9384934,2857,,disrupts,,Celecoxib,,,,breast neoplasm,,,,, +8528907,2858,,disrupts,,Celecoxib,,,,Inflammation,,,,, +19393781,2859,,prevents,,Celecoxib,,,,stroke disorder,,,,, +18309561,2860,,prevents,,Celecoxib,,,,hepatocellular carcinoma,,,,, +17468664,2861,,prevents,,Celecoxib,,,,non-small cell lung carcinoma,,,,, +16386169,2862,,prevents,,Celecoxib,,,,actinic keratosis,,,,, +16323754,2863,,prevents,,Celecoxib,,,,hypertensive disorder,,,,, +15947575,2864,,prevents,,Celecoxib,,,,osteoarthritis,,,,, +15337603,2865,,prevents,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +14688780,2866,,prevents,,Celecoxib,,,,Low back pain,,,,, +13346756,2867,,prevents,,Celecoxib,,,,prostate cancer,,,,, +12969778,2868,,prevents,,Celecoxib,,,,neuroblastoma,,,,, +12687466,2869,,prevents,,Celecoxib,,,,adenoma,,,,, +11060421,2870,,prevents,,Celecoxib,,,,classic familial adenomatous polyposis,,,,, +10931690,2871,,prevents,,Celecoxib,,,,breast neoplasm,,,,, +10337661,2872,,prevents,,Celecoxib,,,,colorectal neoplasm,,,,, +9969498,2873,,prevents,,Celecoxib,,,,Acute Pain,,,,, +9525867,2874,,prevents,,Celecoxib,,,,injury,,,,, +9508533,2875,,prevents,,Celecoxib,,,,Pain,,,,, +8844228,2876,,prevents,,Celecoxib,,,,Inflammation,,,,, +7720173,2877,,prevents,,Celecoxib,,,,neoplasm,,,,, +14426267,2878,,predisposes,,Celecoxib,,,,Inflammation,,,,, +12799788,2879,,predisposes,,Celecoxib,,,,hypertensive disorder,,,,, +11130431,2880,,predisposes,,Celecoxib,,,,injury,,,,, +12352394,2881,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +12352394,2882,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +14685035,2883,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +14685035,2884,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +8460222,2885,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +9140191,2886,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +10265772,2887,,causes,,Rofecoxib,,,,Pain,,,,, +13140649,2888,,affects,,Rofecoxib,,,,Pain,,,,, +13143485,2889,,affects,,Rofecoxib,,,,osteoarthritis,,,,, +12129893,2890,,affects,,Rofecoxib,,,,adenoma,,,,, +11539323,2891,,affects,,Rofecoxib,,,,Pain,,,,, +10337671,2892,,affects,,Rofecoxib,,,,colorectal neoplasm,,,,, +8436303,2893,,affects,,Rofecoxib,,,,osteoarthritis,,,,, +7546790,2894,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +11143316,2895,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +11899486,2896,,disrupts,,Rofecoxib,,,,Pain,,,,, +12422414,2897,,prevents,,Rofecoxib,,,,adenoma,,,,, +10337662,2898,,prevents,,Rofecoxib,,,,colorectal neoplasm,,,,, +9488144,2899,,prevents,,Rofecoxib,,,,Pain,,,,, +12808149,2900,,predisposes,,Rofecoxib,,,,adenoma,,,,, +21440548,2901,,affects,,Etoricoxib,,,,osteoarthritis,,,,, +17783506,2902,,affects,,Etoricoxib,,,,injury,,,,, +15015650,2903,,affects,,Etoricoxib,,,,Pain,,,,, +13276651,2904,,affects,,Etoricoxib,,,,rheumatic disorder,,,,, +8656381,2905,,affects,,Etoricoxib,,,,Cyclooxygenase 2,,,,, +21271381,2906,,prevents,,Etoricoxib,,,,osteoarthritis,,,,, +17783508,2907,,prevents,,Etoricoxib,,,,injury,,,,, +13679347,2908,,prevents,,Etoricoxib,,,,Pain,,,,, +11619190,2909,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +11619190,2910,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +17164065,2911,,physically interacts with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +13276652,2912,,affects,,Lumiracoxib,,,,rheumatic disorder,,,,, +10245332,2913,,affects,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +13077914,2914,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, +11476053,2915,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, +9552647,2916,,affects,,Valdecoxib,,,,Cyclooxygenase 2,,,,, +11215677,2917,,disrupts,,Valdecoxib,,,,Pain,,,,, +15156435,2918,,prevents,,Valdecoxib,,,,pancreatitis,,,,, +10035578,2919,,prevents,,Valdecoxib,,,,Pain,,,,, +17909160,2920,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, +17909160,2921,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, +16597136,2922,,affects,,Parecoxib,,,,Shoulder pain,,,,, +13492238,2923,,affects,,Parecoxib,,,,Pain,,,,, +12600950,2924,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, +18579418,2925,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, +18207264,2926,,disrupts,,Parecoxib,,,,Pain,,,,, +16597135,2927,,prevents,,Parecoxib,,,,Shoulder pain,,,,, +14081775,2928,,prevents,,Parecoxib,,,,Pain,,,,, +22281663,2929,,related to,,Drospirenone,,,,polycystic ovary syndrome,,,,, +21546756,2930,,related to,,Drospirenone,,,,acne,,,,, +20964606,2931,,predisposes,,Drospirenone,,,,polycystic ovary syndrome,,,,, +8455182,2932,,related to,,Ropinirole,,,,Parkinson disease,,,,, +17774585,2933,,causes,,Ropinirole,,,,Parkinson disease,,,,, +14587825,2934,,affects,,Ropinirole,,,,Parkinson disease,,,,, +11791368,2935,,affects,,Ropinirole,,,,restless legs syndrome,,,,, +9334943,2936,,disrupts,,Ropinirole,,,,Parkinson disease,,,,, +10286489,2937,,prevents,,Ropinirole,,,,Parkinson disease,,,,, +27727471,2938,,related to,,Pergolide,,,,Parkinson disease,,,,, +11914502,2939,,causes,,Pergolide,,,,Parkinson disease,,,,, +10881399,2940,,affects,,Pergolide,,,,Parkinson disease,,,,, +16163315,2941,,related to,,Bromocriptine,,,,Parkinson disease,,,,, +15233295,2942,,related to,,Bromocriptine,,,,type 1 diabetes mellitus,,,,, +17352665,2943,,causes,,Bromocriptine,,,,obesity disorder,,,,, +12630193,2944,,causes,,Bromocriptine,,,,Parkinson disease,,,,, +22488533,2945,,affects,,Bromocriptine,,,,adenomyosis,,,,, +20888778,2946,,affects,,Bromocriptine,,,,Parkinson disease,,,,, +27647530,2947,,prevents,,Bromocriptine,,,,obesity disorder,,,,, +15529387,2948,,prevents,,Bromocriptine,,,,ovarian hyperstimulation syndrome,,,,, +18216941,2949,,causes,,Piribedil,,,,Parkinson disease,,,,, +8408670,2950,,affects,,Piribedil,,,,Parkinson disease,,,,, +8818724,2951,,related to,,Apomorphine,,,,Parkinson disease,,,,, +23018637,2952,,causes,,Apomorphine,,,,erectile dysfunction,,,,, +11364291,2953,,causes,,Apomorphine,,,,Parkinson disease,,,,, +8320181,2954,,affects,,Apomorphine,,,,Parkinson disease,,,,, +16869339,2955,,related to,,Cabergoline,,,,Parkinson disease,,,,, +19536611,2956,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, +15320456,2957,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, +20751353,2958,,causes,,Cabergoline,,,,endometriosis,,,,, +26585560,2959,,affects,,Cabergoline,,,,pituitary tumor,,,,, +19237315,2960,,affects,,Cabergoline,,,,endometriosis,,,,, +17463083,2961,,affects,,Cabergoline,,,,Dopamine D2 Receptor,,,,, +12695381,2962,,affects,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, +13380476,2963,,prevents,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, +9194241,2964,,predisposes,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, +15982499,2965,,related to,,Pramipexole,,,,restless legs syndrome,,,,, +9735890,2966,,related to,,Pramipexole,,,,Parkinson disease,,,,, +21401262,2967,,causes,,Pramipexole,,,,restless legs syndrome,,,,, +15033700,2968,,causes,,Pramipexole,,,,obsessive-compulsive disorder,,,,, +13328857,2969,,causes,,Pramipexole,,,,Parkinson disease,,,,, +18143671,2970,,affects,,Pramipexole,,,,depressive disorder,,,,, +12990655,2971,,affects,,Pramipexole,,,,restless legs syndrome,,,,, +12579916,2972,,affects,,Pramipexole,,,,depressive disorder,,,,, +10881401,2973,,affects,,Pramipexole,,,,Parkinson disease,,,,, +11457313,2974,,prevents,,Pramipexole,,,,Parkinson disease,,,,, +24610805,2975,,affects,,Rotigotine,,,,Parkinson disease,,,,, +10840977,2976,,subclass of,,Norethindrone,,,,Norethindrone acetate,,,,, +8232443,2977,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, +11686400,2978,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, +9474851,2979,,coexists with,,Norethindrone,,,,Norethindrone acetate,,,,, +9781055,2980,,physically interacts with,,Norethindrone,,,,Norethindrone acetate,,,,, +21462883,2981,,causes,,Norethindrone,,,,neoplasm,,,,, +27429354,2982,,affects,,Pramocaine,,,,Pruritus,,,,, +19275366,2983,,disrupts,,Miconazole,,,,fungal infectious disease,,,,, +26511975,2984,,prevents,,Miconazole,,,,fungal infectious disease,,,,, +26530559,2985,,affects,,Benzocaine,,,,Pain,,,,, +8870493,2986,,disrupts,,Benzocaine,,,,Pain,,,,, +8870496,2987,,prevents,,Benzocaine,,,,Pain,,,,, +25561815,2988,,related to,,Folic Acid,,,,systemic lupus erythematosus,,,,, +23703706,2989,,related to,,Folic Acid,,,,neoplasm of esophagus,,,,, +23248765,2990,,related to,,Folic Acid,,,,chronic renal failure syndrome,,,,, +20038856,2991,,related to,,Folic Acid,,,,psychotic disorder,,,,, +19346997,2992,,related to,,Folic Acid,,,,myocardial ischemia,,,,, +19301020,2993,,related to,,Folic Acid,,,,type 2 diabetes mellitus,,,,, +19114314,2994,,related to,,Folic Acid,,,,tuberculosis,,,,, +18323097,2995,,related to,,Folic Acid,,,,HIV infectious disease,,,,, +17591518,2996,,related to,,Folic Acid,,,,infertility disorder,,,,, +15826430,2997,,related to,,Folic Acid,,,,male infertility,,,,, +14280104,2998,,related to,,Folic Acid,,,,myocardial infarction,,,,, +12974622,2999,,related to,,Folic Acid,,,,osteoporosis,,,,, +12112288,3000,,related to,,Folic Acid,,,,autism spectrum disorder,,,,, +11305980,3001,,related to,,Folic Acid,,,,cleft palate,,,,, +10745702,3002,,related to,,Folic Acid,,,,malaria,,,,, +10717915,3003,,related to,,Folic Acid,,,,habitual spontaneous abortion,,,,, +10644755,3004,,related to,,Folic Acid,,,,atherosclerosis,,,,, +10226420,3005,,related to,,Folic Acid,,,,cervical polyp,,,,, +10177078,3006,,related to,,Folic Acid,,,,colorectal neoplasm,,,,, +10046990,3007,,related to,,Folic Acid,,,,depressive disorder,,,,, +9815747,3008,,related to,,Folic Acid,,,,hypertensive disorder,,,,, +9628243,3009,,related to,,Folic Acid,,,,mesothelioma,,,,, +9628242,3010,,related to,,Folic Acid,,,,non-small cell lung carcinoma,,,,, +9060030,3011,,related to,,Folic Acid,,,,neoplasm,,,,, +8875457,3012,,related to,,Folic Acid,,,,lymphoma,,,,, +8584638,3013,,related to,,Folic Acid,,,,sickle cell anemia,,,,, +8274471,3014,,related to,,Folic Acid,,,,chronic kidney disease,,,,, +8259960,3015,,related to,,Folic Acid,,,,type 1 diabetes mellitus,,,,, +8078141,3016,,related to,,Folic Acid,,,,Alzheimer disease,,,,, +7868306,3017,,related to,,Folic Acid,,,,coronary artery disorder,,,,, +7765942,3018,,related to,,Folic Acid,,,,anemia,,,,, +7303518,3019,,related to,,Folic Acid,,,,epilepsy,,,,, +7234301,3020,,related to,,Folic Acid,,,,Reduced blood folate concentration,,,,, +7229825,3021,,related to,,Folic Acid,,,,iron deficiency anemia,,,,, +7175279,3022,,related to,,Folic Acid,,,,rheumatoid arthritis,,,,, +25522909,3023,,causes,,Folic Acid,,,,diabetic kidney disease,,,,, +18689556,3024,,causes,,Folic Acid,,,,Alzheimer disease,,,,, +17559847,3025,,causes,,Folic Acid,,,,iron deficiency anemia,,,,, +17044072,3026,,causes,,Folic Acid,,,,depressive disorder,,,,, +15826434,3027,,causes,,Folic Acid,,,,male infertility,,,,, +15057448,3028,,causes,,Folic Acid,,,,chronic kidney disease,,,,, +14954987,3029,,causes,,Folic Acid,,,,autism spectrum disorder,,,,, +13825749,3030,,causes,,Folic Acid,,,,cleft lip,,,,, +13656973,3031,,causes,,Folic Acid,,,,neoplasm,,,,, +12212539,3032,,causes,,Folic Acid,,,,lymphoma,,,,, +11472417,3033,,causes,,Folic Acid,,,,gingival overgrowth,,,,, +11073752,3034,,causes,,Folic Acid,,,,myocardial ischemia,,,,, +10016854,3035,,causes,,Folic Acid,,,,hypertensive disorder,,,,, +8671948,3036,,causes,,Folic Acid,,,,cleft palate,,,,, +8640403,3037,,causes,,Folic Acid,,,,epilepsy,,,,, +7900734,3038,,causes,,Folic Acid,,,,coronary artery disorder,,,,, +7900729,3039,,causes,,Folic Acid,,,,atherosclerosis,,,,, +7637475,3040,,causes,,Folic Acid,,,,Reduced blood folate concentration,,,,, +7460069,3041,,causes,,Folic Acid,,,,anemia,,,,, +7392389,3042,,causes,,Folic Acid,,,,neural tube defect,,,,, +27400709,3043,,affects,,Folic Acid,,,,coronary artery disorder,,,,, +27350602,3044,,affects,,Folic Acid,,,,cleft palate,,,,, +26684582,3045,,affects,,Folic Acid,,,,colorectal neoplasm,,,,, +26504524,3046,,affects,,Folic Acid,,,,neoplasm,,,,, +26433324,3047,,affects,,Folic Acid,,,,psychotic disorder,,,,, +25046427,3048,,affects,,Folic Acid,,,,malaria,,,,, +24121807,3049,,affects,,Folic Acid,,,,osteoporosis,,,,, +23769753,3050,,affects,,Folic Acid,,,,anemia,,,,, +22602503,3051,,affects,,Folic Acid,,,,gingival overgrowth,,,,, +21177262,3052,,affects,,Folic Acid,,,,autism spectrum disorder,,,,, +20060781,3053,,affects,,Folic Acid,,,,Hemorrhage,,,,, +19336710,3054,,affects,,Folic Acid,,,,polycystic ovary syndrome,,,,, +19172236,3055,,affects,,Folic Acid,,,,chronic kidney disease,,,,, +19066599,3056,,affects,,Folic Acid,,,,Alzheimer disease,,,,, +15798837,3057,,affects,,Folic Acid,,,,hypertensive disorder,,,,, +15143772,3058,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, +14869410,3059,,affects,,Folic Acid,,,,epilepsy,,,,, +14664528,3060,,affects,,Folic Acid,,,,depressive disorder,,,,, +14002988,3061,,affects,,Folic Acid,,,,depressive disorder,,,,, +13092563,3062,,affects,,Folic Acid,,,,depressive disorder,,,,, +12773835,3063,,affects,,Folic Acid,,,,atherosclerosis,,,,, +11897009,3064,,affects,,Folic Acid,,,,Alzheimer disease,,,,, +10798682,3065,,affects,,Folic Acid,,,,type 2 diabetes mellitus,,,,, +10733114,3066,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, +10375553,3067,,affects,,Folic Acid,,,,neoplasm,,,,, +10355008,3068,,affects,,Folic Acid,,,,anemia,,,,, +8962241,3069,,affects,,Folic Acid,,,,cleft palate,,,,, +8101952,3070,,affects,,Folic Acid,,,,neural tube defect,,,,, +7127212,3071,,affects,,Folic Acid,,,,neural tube defect,,,,, +19290979,3072,,produces,,Folic Acid,,,,neoplasm,,,,, +26301481,3073,,disrupts,,Folic Acid,,,,epilepsy,,,,, +22602502,3074,,disrupts,,Folic Acid,,,,gingival overgrowth,,,,, +21452213,3075,,disrupts,,Folic Acid,,,,cleft palate,,,,, +20711939,3076,,disrupts,,Folic Acid,,,,autism spectrum disorder,,,,, +20091947,3077,,disrupts,,Folic Acid,,,,atherosclerosis,,,,, +18758283,3078,,disrupts,,Folic Acid,,,,malaria,,,,, +18711179,3079,,disrupts,,Folic Acid,,,,hypertensive disorder,,,,, +16597425,3080,,disrupts,,Folic Acid,,,,neoplasm,,,,, +13887579,3081,,disrupts,,Folic Acid,,,,anemia,,,,, +13415357,3082,,disrupts,,Folic Acid,,,,cleft lip,,,,, +12569851,3083,,disrupts,,Folic Acid,,,,HIV infectious disease,,,,, +11807458,3084,,disrupts,,Folic Acid,,,,colorectal neoplasm,,,,, +10170875,3085,,disrupts,,Folic Acid,,,,depressive disorder,,,,, +8333532,3086,,disrupts,,Folic Acid,,,,neural tube defect,,,,, +8088152,3087,,disrupts,,Folic Acid,,,,Reduced blood folate concentration,,,,, +7255352,3088,,disrupts,,Folic Acid,,,,coronary artery disorder,,,,, +24827653,3089,,prevents,,Folic Acid,,,,Hemorrhage,,,,, +19249670,3090,,prevents,,Folic Acid,,,,epilepsy,,,,, +18676969,3091,,prevents,,Folic Acid,,,,neoplasm,,,,, +17577921,3092,,prevents,,Folic Acid,,,,diabetic kidney disease,,,,, +16233198,3093,,prevents,,Folic Acid,,,,iron deficiency anemia,,,,, +15458838,3094,,prevents,,Folic Acid,,,,myocardial ischemia,,,,, +15385859,3095,,prevents,,Folic Acid,,,,depressive disorder,,,,, +13602735,3096,,prevents,,Folic Acid,,,,gingival overgrowth,,,,, +12999215,3097,,prevents,,Folic Acid,,,,hypertensive disorder,,,,, +12947495,3098,,prevents,,Folic Acid,,,,cleft lip,,,,, +12911127,3099,,prevents,,Folic Acid,,,,Alzheimer disease,,,,, +11842763,3100,,prevents,,Folic Acid,,,,cervical polyp,,,,, +10283354,3101,,prevents,,Folic Acid,,,,heart disorder,,,,, +10242010,3102,,prevents,,Folic Acid,,,,cleft palate,,,,, +9547944,3103,,prevents,,Folic Acid,,,,atherosclerosis,,,,, +9000016,3104,,prevents,,Folic Acid,,,,anemia,,,,, +8746975,3105,,prevents,,Folic Acid,,,,Reduced blood folate concentration,,,,, +8675157,3106,,prevents,,Folic Acid,,,,coronary artery disorder,,,,, +8467407,3107,,prevents,,Folic Acid,,,,myocardial infarction,,,,, +7303516,3108,,prevents,,Folic Acid,,,,neural tube defect,,,,, +23795062,3109,,predisposes,,Folic Acid,,,,depressive disorder,,,,, +20875914,3110,,predisposes,,Folic Acid,,,,chronic kidney disease,,,,, +20436878,3111,,predisposes,,Folic Acid,,,,psychotic disorder,,,,, +19071958,3112,,predisposes,,Folic Acid,,,,type 1 diabetes mellitus,,,,, +18723777,3113,,predisposes,,Folic Acid,,,,systemic lupus erythematosus,,,,, +16571781,3114,,predisposes,,Folic Acid,,,,habitual spontaneous abortion,,,,, +16186991,3115,,predisposes,,Folic Acid,,,,Reduced blood folate concentration,,,,, +15780148,3116,,predisposes,,Folic Acid,,,,epilepsy,,,,, +15351663,3117,,predisposes,,Folic Acid,,,,breast neoplasm,,,,, +14681570,3118,,predisposes,,Folic Acid,,,,malaria,,,,, +13204073,3119,,predisposes,,Folic Acid,,,,autism spectrum disorder,,,,, +12966788,3120,,predisposes,,Folic Acid,,,,cleft palate,,,,, +12851634,3121,,predisposes,,Folic Acid,,,,osteoporosis,,,,, +12628867,3122,,predisposes,,Folic Acid,,,,neoplasm,,,,, +11373442,3123,,predisposes,,Folic Acid,,,,colorectal neoplasm,,,,, +11241979,3124,,predisposes,,Folic Acid,,,,hypertensive disorder,,,,, +9419598,3125,,predisposes,,Folic Acid,,,,Alzheimer disease,,,,, +9024956,3126,,predisposes,,Folic Acid,,,,non-small cell lung carcinoma,,,,, +8876702,3127,,predisposes,,Folic Acid,,,,atherosclerosis,,,,, +8590186,3128,,predisposes,,Folic Acid,,,,anemia,,,,, +8210149,3129,,predisposes,,Folic Acid,,,,myocardial ischemia,,,,, +8202566,3130,,predisposes,,Folic Acid,,,,coronary artery disorder,,,,, +7807562,3131,,predisposes,,Folic Acid,,,,myocardial infarction,,,,, +7720012,3132,,subclass of,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +26246718,3133,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +25613560,3134,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +20340997,3135,,physically interacts with,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +26417219,3136,,physically interacts with,,Phenylbutazone,,,,"1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",,,,, +17467114,3137,,affects,,Phenylbutazone,,,,rheumatic disorder,,,,, +8146434,3138,,affects,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +7720012,3139,,subclass of,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +25613560,3140,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +26246718,3141,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +20340997,3142,,physically interacts with,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +8146434,3143,,affects,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +19336632,3144,,prevents,,Etofenamate,,,,Arthralgia,,,,, +11418550,3145,,subclass of,,Piroxicam,,,,5'-Hydroxypiroxicam,,,,, +27695181,3146,,affects,,Piroxicam,,,,osteoarthritis,,,,, +24435495,3147,,affects,,Piroxicam,,,,Pain,,,,, +18791248,3148,,disrupts,,Piroxicam,,,,Pain,,,,, +13746683,3149,,prevents,,Piroxicam,,,,Myalgia,,,,, +13092622,3150,,prevents,,Piroxicam,,,,Pain,,,,, +9050885,3151,,related to,,Bufexamac,,,,rheumatic disorder,,,,, +27600921,3152,,related to,,Mometasone furoate,,,,psoriasis,,,,, +26936147,3153,,related to,,Mometasone furoate,,,,skin disorder,,,,, +20328277,3154,,related to,,Mometasone furoate,,,,obstructive sleep apnea syndrome,,,,, +20031657,3155,,related to,,Mometasone furoate,,,,diffuse alopecia areata,,,,, +18451558,3156,,related to,,Mometasone furoate,,,,spinal cord injury,,,,, +15193244,3157,,related to,,Mometasone furoate,,,,severe acute respiratory syndrome,,,,, +12129006,3158,,related to,,Mometasone furoate,,,,asthma,,,,, +12122099,3159,,related to,,Mometasone furoate,,,,allergic rhinitis,,,,, +11696210,3160,,related to,,Mometasone furoate,,,,chronic obstructive pulmonary disease,,,,, +10078337,3161,,related to,,Mometasone furoate,,,,perennial allergic rhinitis,,,,, +8366912,3162,,related to,,Mometasone furoate,,,,seasonal allergic rhinitis,,,,, +15620377,3163,,affects,,Mometasone furoate,,,,asthma,,,,, +14474022,3164,,affects,,Mometasone furoate,,,,Nasal congestion,,,,, +8375063,3165,,affects,,Mometasone furoate,,,,allergic rhinitis,,,,, +17026384,3166,,prevents,,Mometasone furoate,,,,Nasal congestion,,,,, +15945486,3167,,prevents,,Mometasone furoate,,,,nasal cavity polyp,,,,, +10581126,3168,,related to,,Methimazole,,,,hyperthyroidism,,,,, +8213703,3169,,causes,,Methimazole,,,,hyperthyroidism,,,,, +10543639,3170,,affects,,Methimazole,,,,hyperthyroidism,,,,, +25010771,3171,,prevents,,Methimazole,,,,hyperthyroidism,,,,, +24946616,3172,,physically interacts with,,Safinamide,,,,Monoamine Oxidase B,,,,, +19231919,3173,,affects,,Safinamide,,,,Parkinson disease,,,,, +13464423,3174,,affects,,Safinamide,,,,Monoamine Oxidase B,,,,, +25942595,3175,,related to,,Furosemide,,,,nephrotic syndrome,,,,, +25824332,3176,,related to,,Furosemide,,,,Fibrosis,,,,, +25791999,3177,,related to,,Furosemide,,,,cirrhosis of liver,,,,, +25414865,3178,,related to,,Furosemide,,,,syndromic disease,,,,, +24461287,3179,,related to,,Furosemide,,,,essential hypertension,,,,, +22834232,3180,,related to,,Furosemide,,,,type 2 diabetes mellitus,,,,, +19148228,3181,,related to,,Furosemide,,,,hypertensive disorder,,,,, +13031496,3182,,related to,,Furosemide,,,,acute kidney failure,,,,, +8084093,3183,,related to,,Furosemide,,,,kidney failure,,,,, +27482853,3184,,causes,,Furosemide,,,,Edema,,,,, +27015887,3185,,causes,,Furosemide,,,,diabetes mellitus,,,,, +25990601,3186,,causes,,Furosemide,,,,hypertensive disorder,,,,, +25918508,3187,,causes,,Furosemide,,,,kidney disorder,,,,, +20167150,3188,,causes,,Furosemide,,,,syndromic disease,,,,, +19659078,3189,,causes,,Furosemide,,,,kidney failure,,,,, +11605290,3190,,causes,,Furosemide,,,,nephrotic syndrome,,,,, +9601857,3191,,causes,,Furosemide,,,,acute kidney failure,,,,, +8252635,3192,,causes,,Furosemide,,,,Dyspnea,,,,, +26185017,3193,,affects,,Furosemide,,,,myocardial infarction,,,,, +25909260,3194,,affects,,Furosemide,,,,nephrotic syndrome,,,,, +22504977,3195,,affects,,Furosemide,,,,cirrhosis of liver,,,,, +17729926,3196,,affects,,Furosemide,,,,Edema,,,,, +16155102,3197,,affects,,Furosemide,,,,kidney disorder,,,,, +15732141,3198,,affects,,Furosemide,,,,hypertensive disorder,,,,, +14935630,3199,,affects,,Furosemide,,,,kidney failure,,,,, +14887041,3200,,affects,,Furosemide,,,,acute kidney failure,,,,, +14148250,3201,,affects,,Furosemide,,,,kidney failure,,,,, +13740455,3202,,affects,,Furosemide,,,,Dyspnea,,,,, +12836864,3203,,affects,,Furosemide,,,,Edema,,,,, +10718312,3204,,affects,,Furosemide,,,,diabetes mellitus,,,,, +8299615,3205,,affects,,Furosemide,,,,acute kidney failure,,,,, +27482854,3206,,disrupts,,Furosemide,,,,Edema,,,,, +19844878,3207,,disrupts,,Furosemide,,,,Dyspnea,,,,, +24717003,3208,,prevents,,Furosemide,,,,pulmonary edema,,,,, +22953098,3209,,prevents,,Furosemide,,,,Dyspnea,,,,, +21527038,3210,,prevents,,Furosemide,,,,schizophrenia,,,,, +20769925,3211,,prevents,,Furosemide,,,,bronchopulmonary dysplasia,,,,, +12415888,3212,,prevents,,Furosemide,,,,kidney disorder,,,,, +11075685,3213,,prevents,,Furosemide,,,,hypertensive disorder,,,,, +9165205,3214,,prevents,,Furosemide,,,,Edema,,,,, +8733555,3215,,prevents,,Furosemide,,,,syndromic disease,,,,, +7901682,3216,,prevents,,Furosemide,,,,kidney failure,,,,, +24388792,3217,,predisposes,,Furosemide,,,,acute kidney failure,,,,, +23800241,3218,,predisposes,,Furosemide,,,,myocardial infarction,,,,, +21525697,3219,,predisposes,,Furosemide,,,,atherosclerosis,,,,, +16660855,3220,,predisposes,,Furosemide,,,,kidney disorder,,,,, +19565633,3221,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, +14176438,3222,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, +15189827,3223,,affects,,Nabumetone,,,,osteoarthritis,,,,, +9219116,3224,,affects,,Nabumetone,,,,Cyclooxygenase 2,,,,, +11784119,3225,,related to,,Selegiline,,,,Parkinson disease,,,,, +7091710,3226,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, +7091710,3227,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, +26670675,3228,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, +26670675,3229,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, +13016594,3230,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, +26762387,3231,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, +27251718,3232,,causes,,Selegiline,,,,depressive disorder,,,,, +18216942,3233,,causes,,Selegiline,,,,Parkinson disease,,,,, +8842901,3234,,affects,,Selegiline,,,,Parkinson disease,,,,, +7091708,3235,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, +8615177,3236,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, +11022843,3237,,disrupts,,Selegiline,,,,Parkinson disease,,,,, +8202759,3238,,prevents,,Selegiline,,,,depressive disorder,,,,, +7205408,3239,,prevents,,Selegiline,,,,Parkinson disease,,,,, +21543223,3240,,causes,,Bumetanide,,,,pervasive developmental disorder,,,,, +22325231,3241,,affects,,Bumetanide,,,,pervasive developmental disorder,,,,, +20190253,3242,,affects,,Bumetanide,,,,autism spectrum disorder,,,,, +16914848,3243,,prevents,,Bumetanide,,,,autism spectrum disorder,,,,, +11943751,3244,,related to,,D-Glucosamine,,,,breast neoplasm,,,,, +7809202,3245,,related to,,D-Glucosamine,,,,osteoarthritis,,,,, +27619077,3246,,causes,,D-Glucosamine,,,,obesity disorder,,,,, +18633463,3247,,causes,,D-Glucosamine,,,,osteoarthritis,,,,, +9909825,3248,,affects,,D-Glucosamine,,,,osteoarthritis,,,,, +8968754,3249,,affects,,D-Glucosamine,,,,obesity disorder,,,,, +13460623,3250,,disrupts,,D-Glucosamine,,,,osteoarthritis,,,,, +11817662,3251,,prevents,,D-Glucosamine,,,,osteoarthritis,,,,, +25749858,3252,,causes,,Torsemide,,,,hypertensive disorder,,,,, +26478746,3253,,affects,,Torsemide,,,,hypertensive disorder,,,,, +13754465,3254,,affects,,Torsemide,,,,hypertensive disorder,,,,, +24478260,3255,,related to,,Leuprorelin,,,,infertility disorder,,,,, +22375547,3256,,related to,,Leuprorelin,,,,neoplasm,,,,, +17696905,3257,,related to,,Leuprorelin,,,,leiomyoma,,,,, +16368292,3258,,related to,,Leuprorelin,,,,prostate cancer,,,,, +15413679,3259,,related to,,Leuprorelin,,,,endometriosis,,,,, +9878755,3260,,causes,,Leuprorelin,,,,hypogonadism,,,,, +7418968,3261,,causes,,Leuprorelin,,,,neoplasm,,,,, +27571709,3262,,affects,,Leuprorelin,,,,prostate cancer,,,,, +27571708,3263,,affects,,Leuprorelin,,,,endometriosis,,,,, +26547561,3264,,affects,,Leuprorelin,,,,endometriosis,,,,, +26152029,3265,,affects,,Leuprorelin,,,,prostate cancer,,,,, +27542556,3266,,prevents,,Leuprorelin,,,,neoplasm,,,,, +12402472,3267,,prevents,,Leuprorelin,,,,Pain,,,,, +7814590,3268,,subclass of,,Sodium Bicarbonate,,,,Electrolytes,,,,, +26447678,3269,,related to,,Sodium Bicarbonate,,,,cystic fibrosis,,,,, +26270339,3270,,related to,,Sodium Bicarbonate,,,,kidney failure,,,,, +20718850,3271,,related to,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +15047625,3272,,related to,,Sodium Bicarbonate,,,,Pain,,,,, +14688492,3273,,related to,,Sodium Bicarbonate,,,,chronic renal failure syndrome,,,,, +13166244,3274,,related to,,Sodium Bicarbonate,,,,kidney disorder,,,,, +12100581,3275,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, +13772853,3276,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, +27495118,3277,,causes,,Sodium Bicarbonate,,,,kidney failure,,,,, +18327883,3278,,causes,,Sodium Bicarbonate,,,,kidney disorder,,,,, +14549296,3279,,causes,,Sodium Bicarbonate,,,,injury,,,,, +8914995,3280,,causes,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +25712033,3281,,affects,,Sodium Bicarbonate,,,,Abnormality of acid-base homeostasis,,,,, +18411502,3282,,affects,,Sodium Bicarbonate,,,,injury,,,,, +17654743,3283,,affects,,Sodium Bicarbonate,,,,kidney disorder,,,,, +12960490,3284,,affects,,Sodium Bicarbonate,,,,Pain,,,,, +8914994,3285,,affects,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +14651482,3286,,disrupts,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +21103228,3287,,prevents,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +13938650,3288,,prevents,,Sodium Bicarbonate,,,,injury,,,,, +11746267,3289,,prevents,,Sodium Bicarbonate,,,,kidney failure,,,,, +11205688,3290,,prevents,,Sodium Bicarbonate,,,,acute kidney failure,,,,, +11205686,3291,,prevents,,Sodium Bicarbonate,,,,kidney disorder,,,,, +14663272,3292,,predisposes,,Sodium Bicarbonate,,,,kidney disorder,,,,, +14542214,3293,,predisposes,,Sodium Bicarbonate,,,,injury,,,,, +17530350,3294,,affects,,Olmesartan medoxomil,,,,diabetic kidney disease,,,,, +12894557,3295,,affects,,Olmesartan medoxomil,,,,atherosclerosis,,,,, +12254737,3296,,affects,,Olmesartan medoxomil,,,,diabetes mellitus,,,,, +15583038,3297,,disrupts,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, +12254736,3298,,disrupts,,Olmesartan medoxomil,,,,proteinuria,,,,, +12254735,3299,,prevents,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, +9359700,3300,,prevents,,Olmesartan medoxomil,,,,atherosclerosis,,,,, +8752749,3301,,related to,,Candesartan,,,,essential hypertension,,,,, +20752265,3302,,causes,,Candesartan,,,,Cognitive impairment,,,,, +14838058,3303,,causes,,Candesartan,,,,hypertensive disorder,,,,, +20512666,3304,,affects,,Candesartan,,,,Cognitive impairment,,,,, +20051167,3305,,affects,,Candesartan,,,,hypertensive disorder,,,,, +19501045,3306,,affects,,Candesartan,,,,Cognitive impairment,,,,, +14118850,3307,,affects,,Candesartan,,,,Left ventricular hypertrophy,,,,, +9919312,3308,,affects,,Candesartan,,,,hypertensive disorder,,,,, +14542524,3309,,disrupts,,Candesartan,,,,Left ventricular hypertrophy,,,,, +9479295,3310,,disrupts,,Candesartan,,,,hypertensive disorder,,,,, +24756017,3311,,prevents,,Candesartan,,,,Cognitive impairment,,,,, +15502429,3312,,prevents,,Candesartan,,,,cardiovascular disorder,,,,, +12994289,3313,,prevents,,Candesartan,,,,Left ventricular hypertrophy,,,,, +12444324,3314,,prevents,,Candesartan,,,,atrial fibrillation,,,,, +12421723,3315,,prevents,,Candesartan,,,,migraine disorder,,,,, +8787605,3316,,prevents,,Candesartan,,,,hypertensive disorder,,,,, +9420113,3317,,related to,,Telmisartan,,,,diabetes mellitus,,,,, +9420112,3318,,related to,,Telmisartan,,,,hypertensive disorder,,,,, +16669618,3319,,causes,,Telmisartan,,,,cardiovascular disorder,,,,, +16637024,3320,,causes,,Telmisartan,,,,hypertensive disorder,,,,, +16559226,3321,,causes,,Telmisartan,,,,myocardial infarction,,,,, +14418892,3322,,causes,,Telmisartan,,,,Albuminuria,,,,, +13301662,3323,,causes,,Telmisartan,,,,diabetes mellitus,,,,, +20835589,3324,,affects,,Telmisartan,,,,diabetic kidney disease,,,,, +17882285,3325,,affects,,Telmisartan,,,,Albuminuria,,,,, +16266744,3326,,affects,,Telmisartan,,,,Albuminuria,,,,, +15802746,3327,,affects,,Telmisartan,,,,diabetes mellitus,,,,, +13992848,3328,,affects,,Telmisartan,,,,diabetes mellitus,,,,, +13861721,3329,,affects,,Telmisartan,,,,type 2 diabetes mellitus,,,,, +13824093,3330,,affects,,Telmisartan,,,,Albuminuria,,,,, +13501012,3331,,affects,,Telmisartan,,,,essential hypertension,,,,, +13178302,3332,,affects,,Telmisartan,,,,hypertensive disorder,,,,, +25051574,3333,,disrupts,,Telmisartan,,,,Alzheimer disease,,,,, +14418891,3334,,disrupts,,Telmisartan,,,,Albuminuria,,,,, +13325686,3335,,disrupts,,Telmisartan,,,,hypertensive disorder,,,,, +21182197,3336,,prevents,,Telmisartan,,,,Alzheimer disease,,,,, +17513403,3337,,prevents,,Telmisartan,,,,myocardial infarction,,,,, +17170882,3338,,prevents,,Telmisartan,,,,type 2 diabetes mellitus,,,,, +13010398,3339,,prevents,,Telmisartan,,,,stroke disorder,,,,, +12278433,3340,,prevents,,Telmisartan,,,,diabetic kidney disease,,,,, +11585228,3341,,prevents,,Telmisartan,,,,diabetes mellitus,,,,, +11585227,3342,,prevents,,Telmisartan,,,,cardiovascular disorder,,,,, +11473935,3343,,prevents,,Telmisartan,,,,hypertensive disorder,,,,, +17028323,3344,,predisposes,,Telmisartan,,,,stroke disorder,,,,, +17028322,3345,,predisposes,,Telmisartan,,,,myocardial infarction,,,,, +21651336,3346,,causes,,Irbesartan,,,,hypertensive disorder,,,,, +19454247,3347,,affects,,Irbesartan,,,,Sepsis,,,,, +13143483,3348,,affects,,Irbesartan,,,,type 2 diabetes mellitus,,,,, +9015828,3349,,affects,,Irbesartan,,,,chronic kidney disease,,,,, +9015827,3350,,affects,,Irbesartan,,,,diabetic kidney disease,,,,, +7812861,3351,,affects,,Irbesartan,,,,acute kidney failure,,,,, +19016605,3352,,disrupts,,Irbesartan,,,,atrial fibrillation,,,,, +11936096,3353,,disrupts,,Irbesartan,,,,hypertensive disorder,,,,, +9297339,3354,,disrupts,,Irbesartan,,,,diabetic kidney disease,,,,, +11467158,3355,,prevents,,Irbesartan,,,,chronic kidney disease,,,,, +9856662,3356,,prevents,,Irbesartan,,,,diabetic kidney disease,,,,, +8753962,3357,,prevents,,Irbesartan,,,,hypertensive disorder,,,,, +15497727,3358,,predisposes,,Irbesartan,,,,cardiovascular disorder,,,,, +12041301,3359,,predisposes,,Irbesartan,,,,IgA glomerulonephritis,,,,, +9459261,3360,,related to,,Eprosartan,,,,essential hypertension,,,,, +8111433,3361,,related to,,Valsartan,,,,essential hypertension,,,,, +18505936,3362,,causes,,Valsartan,,,,myocardial infarction,,,,, +13301661,3363,,causes,,Valsartan,,,,diabetes mellitus,,,,, +18533693,3364,,affects,,Valsartan,,,,hypertensive disorder,,,,, +18130226,3365,,affects,,Valsartan,,,,stroke disorder,,,,, +16609149,3366,,affects,,Valsartan,,,,kidney disorder,,,,, +9837968,3367,,affects,,Valsartan,,,,Abnormal left ventricular function,,,,, +15479686,3368,,disrupts,,Valsartan,,,,type 2 diabetes mellitus,,,,, +11438135,3369,,disrupts,,Valsartan,,,,atherosclerosis,,,,, +20671333,3370,,prevents,,Valsartan,,,,Abnormal left ventricular function,,,,, +15012324,3371,,prevents,,Valsartan,,,,type 2 diabetes mellitus,,,,, +13899819,3372,,prevents,,Valsartan,,,,stroke disorder,,,,, +12374506,3373,,prevents,,Valsartan,,,,diabetes mellitus,,,,, +12038680,3374,,prevents,,Valsartan,,,,myocardial infarction,,,,, +11801448,3375,,prevents,,Valsartan,,,,atrial fibrillation,,,,, +8617185,3376,,prevents,,Valsartan,,,,coronary artery disorder,,,,, +7691192,3377,,prevents,,Valsartan,,,,hypertensive disorder,,,,, +7604460,3378,,prevents,,Valsartan,,,,atherosclerosis,,,,, +21524148,3379,,predisposes,,Valsartan,,,,myocardial infarction,,,,, +11133518,3380,,predisposes,,Valsartan,,,,cardiovascular disorder,,,,, +13065808,3381,,related to,,Losartan,,,,non-alcoholic fatty liver disease,,,,, +12094342,3382,,related to,,Losartan,,,,proteinuria,,,,, +11472713,3383,,related to,,Losartan,,,,kidney disorder,,,,, +10013644,3384,,related to,,Losartan,,,,hypertensive disorder,,,,, +8975375,3385,,related to,,Losartan,,,,IgA glomerulonephritis,,,,, +16215194,3386,,causes,,Losartan,,,,injury,,,,, +15690681,3387,,causes,,Losartan,,,,kidney disorder,,,,, +9749061,3388,,causes,,Losartan,,,,hypertensive disorder,,,,, +7310301,3389,,causes,,Losartan,,,,proteinuria,,,,, +7204638,3390,,causes,,Losartan,,,,Left ventricular hypertrophy,,,,, +26608778,3391,,affects,,Losartan,,,,essential hypertension,,,,, +24425437,3392,,affects,,Losartan,,,,cystic fibrosis,,,,, +21888728,3393,,affects,,Losartan,,,,proteinuria,,,,, +20488125,3394,,affects,,Losartan,,,,hypertensive disorder,,,,, +19990804,3395,,affects,,Losartan,,,,aortic valve insufficiency,,,,, +18707849,3396,,affects,,Losartan,,,,hypertrophic cardiomyopathy,,,,, +16976701,3397,,affects,,Losartan,,,,IgA glomerulonephritis,,,,, +13986638,3398,,affects,,Losartan,,,,adult acute respiratory distress syndrome,,,,, +13539739,3399,,affects,,Losartan,,,,proteinuria,,,,, +13498248,3400,,affects,,Losartan,,,,Inflammation,,,,, +12531070,3401,,affects,,Losartan,,,,Left ventricular hypertrophy,,,,, +10809955,3402,,affects,,Losartan,,,,hypertensive disorder,,,,, +9615315,3403,,affects,,Losartan,,,,diabetic kidney disease,,,,, +9459571,3404,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, +9229634,3405,,affects,,Losartan,,,,kidney disorder,,,,, +8678480,3406,,affects,,Losartan,,,,injury,,,,, +8551167,3407,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, +18715311,3408,,disrupts,,Losartan,,,,breast neoplasm,,,,, +14458903,3409,,disrupts,,Losartan,,,,pancreatic neoplasm,,,,, +13976332,3410,,disrupts,,Losartan,,,,diabetic kidney disease,,,,, +12949848,3411,,disrupts,,Losartan,,,,Inflammation,,,,, +9870082,3412,,disrupts,,Losartan,,,,hypertensive disorder,,,,, +9655766,3413,,disrupts,,Losartan,,,,type 2 diabetes mellitus,,,,, +8325352,3414,,disrupts,,Losartan,,,,Left ventricular hypertrophy,,,,, +7975855,3415,,disrupts,,Losartan,,,,injury,,,,, +7310299,3416,,disrupts,,Losartan,,,,proteinuria,,,,, +21356716,3417,,prevents,,Losartan,,,,post-traumatic stress disorder,,,,, +14540327,3418,,prevents,,Losartan,,,,kidney disorder,,,,, +12407992,3419,,prevents,,Losartan,,,,Inflammation,,,,, +10030687,3420,,prevents,,Losartan,,,,cardiovascular disorder,,,,, +9856661,3421,,prevents,,Losartan,,,,diabetic kidney disease,,,,, +9773800,3422,,prevents,,Losartan,,,,Left ventricular hypertrophy,,,,, +9766007,3423,,prevents,,Losartan,,,,adult acute respiratory distress syndrome,,,,, +9420091,3424,,prevents,,Losartan,,,,Stenosis,,,,, +9077908,3425,,prevents,,Losartan,,,,proteinuria,,,,, +8542944,3426,,prevents,,Losartan,,,,injury,,,,, +7768196,3427,,prevents,,Losartan,,,,hypertensive disorder,,,,, +14272023,3428,,predisposes,,Losartan,,,,kidney disorder,,,,, +12616336,3429,,predisposes,,Losartan,,,,cardiovascular disorder,,,,, +9964252,3430,,predisposes,,Losartan,,,,Left ventricular hypertrophy,,,,, +20586471,3431,,related to,,Dronabinol,,,,multiple sclerosis,,,,, +25459397,3432,,causes,,Dronabinol,,,,cannabis dependence,,,,, +22027243,3433,,causes,,Dronabinol,,,,Nausea,,,,, +17252204,3434,,causes,,Dronabinol,,,,schizophrenia,,,,, +12205989,3435,,causes,,Dronabinol,,,,Cognitive impairment,,,,, +27448088,3436,,affects,,Dronabinol,,,,Anorexia,,,,, +25890458,3437,,affects,,Dronabinol,,,,Nausea,,,,, +21879717,3438,,affects,,Dronabinol,,,,anorexia nervosa,,,,, +20855895,3439,,affects,,Dronabinol,,,,neoplasm,,,,, +19991701,3440,,affects,,Dronabinol,,,,obstructive sleep apnea syndrome,,,,, +19474044,3441,,affects,,Dronabinol,,,,multiple sclerosis,,,,, +16547908,3442,,affects,,Dronabinol,,,,schizophrenia,,,,, +14443952,3443,,affects,,Dronabinol,,,,opiate dependence,,,,, +13958866,3444,,affects,,Dronabinol,,,,Cognitive impairment,,,,, +13933776,3445,,affects,,Dronabinol,,,,schizophrenia,,,,, +11304843,3446,,affects,,Dronabinol,,,,neuralgia,,,,, +11058493,3447,,affects,,Dronabinol,,,,Pain,,,,, +24013541,3448,,disrupts,,Dronabinol,,,,Pain,,,,, +17477155,3449,,disrupts,,Dronabinol,,,,HIV infectious disease,,,,, +11615857,3450,,disrupts,,Dronabinol,,,,Nausea,,,,, +25196408,3451,,prevents,,Dronabinol,,,,dementia,,,,, +25026370,3452,,prevents,,Dronabinol,,,,neuralgia,,,,, +18579580,3453,,prevents,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, +18554637,3454,,prevents,,Dronabinol,,,,Nausea,,,,, +17477149,3455,,prevents,,Dronabinol,,,,HIV infectious disease,,,,, +9671016,3456,,prevents,,Dronabinol,,,,Pain,,,,, +22976957,3457,,predisposes,,Dronabinol,,,,Cognitive impairment,,,,, +18579581,3458,,predisposes,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, +26722658,3459,,affects,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, +26699974,3460,,affects,,Cesamet,,,,Nausea,,,,, +19460580,3461,,prevents,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, +25552574,3462,,related to,,Aprepitant,,,,glioblastoma,,,,, +18054447,3463,,related to,,Aprepitant,,,,Vomiting,,,,, +18054446,3464,,related to,,Aprepitant,,,,Nausea,,,,, +11788538,3465,,causes,,Aprepitant,,,,Vomiting,,,,, +11788537,3466,,causes,,Aprepitant,,,,Nausea,,,,, +23692862,3467,,affects,,Aprepitant,,,,Nausea,,,,, +19750085,3468,,affects,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, +17874842,3469,,affects,,Aprepitant,,,,Vomiting,,,,, +12562288,3470,,affects,,Aprepitant,,,,Nausea,,,,, +11119543,3471,,affects,,Aprepitant,,,,Vomiting,,,,, +19013645,3472,,disrupts,,Aprepitant,,,,HIV infectious disease,,,,, +16125731,3473,,disrupts,,Aprepitant,,,,Vomiting,,,,, +16125730,3474,,disrupts,,Aprepitant,,,,Nausea,,,,, +16513148,3475,,prevents,,Aprepitant,,,,Pruritus,,,,, +15868137,3476,,prevents,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, +10160541,3477,,prevents,,Aprepitant,,,,Vomiting,,,,, +10160540,3478,,prevents,,Aprepitant,,,,Nausea,,,,, +20804596,3479,,predisposes,,Aprepitant,,,,Nausea,,,,, +22122089,3480,,affects,,Neratinib,,,,neoplasm,,,,, +21597229,3481,,related to,,Lapatinib,,,,neoplasm,,,,, +13650844,3482,,related to,,Lapatinib,,,,non-small cell lung carcinoma,,,,, +18268107,3483,,affects,,Lapatinib,,,,neoplasm,,,,, +15442238,3484,,affects,,Lapatinib,,,,breast neoplasm,,,,, +14691634,3485,,affects,,Lapatinib,,,,neoplasm,,,,, +17546445,3486,,disrupts,,Lapatinib,,,,neoplasm,,,,, +19410918,3487,,prevents,,Lapatinib,,,,breast neoplasm,,,,, +19317295,3488,,prevents,,Lapatinib,,,,neoplasm,,,,, +16643911,3489,,predisposes,,Lapatinib,,,,neoplasm,,,,, +24360220,3490,,related to,,Nifurtimox,,,,human African trypanosomiasis,,,,, +25977066,3491,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, +25977066,3492,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, +25822629,3493,,causes,,Nifurtimox,,,,Chagas disease,,,,, +21140520,3494,,affects,,Nifurtimox,,,,neuroblastoma,,,,, +19390598,3495,,affects,,Nifurtimox,,,,trypanosomiasis,,,,, +18236131,3496,,affects,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, +21140519,3497,,disrupts,,Nifurtimox,,,,neuroblastoma,,,,, +16729888,3498,,prevents,,Nifurtimox,,,,Chagas disease,,,,, +8359719,3499,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +8359719,3500,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +21506050,3501,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +16350865,3502,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +26982963,3503,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, +14891197,3504,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, +13216168,3505,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, +9844335,3506,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, +11447618,3507,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, +11253841,3508,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, +8806634,3509,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, +26997768,3510,,affects,,Metopimazine,,,,Nausea,,,,, +12265728,3511,,prevents,,Metopimazine,,,,Nausea,,,,, +27200379,3512,,related to,,Lincomycin,,,,osteomyelitis,,,,, +9905527,3513,,causes,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +9905522,3514,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +8547552,3515,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +11060423,3516,,prevents,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +20876966,3517,,related to,,Ketorolac,,,,migraine disorder,,,,, +27688883,3518,,causes,,Ketorolac,,,,Inflammation,,,,, +21368479,3519,,causes,,Ketorolac,,,,pancreatitis,,,,, +19597016,3520,,causes,,Ketorolac,,,,Miosis,,,,, +12090892,3521,,causes,,Ketorolac,,,,Pain,,,,, +20018980,3522,,affects,,Ketorolac,,,,breast neoplasm,,,,, +19245410,3523,,affects,,Ketorolac,,,,Miosis,,,,, +9719257,3524,,affects,,Ketorolac,,,,Pain,,,,, +24071071,3525,,disrupts,,Ketorolac,,,,Headache,,,,, +24029444,3526,,disrupts,,Ketorolac,,,,Inflammation,,,,, +11549492,3527,,disrupts,,Ketorolac,,,,Pain,,,,, +11362008,3528,,disrupts,,Ketorolac,,,,Back pain,,,,, +24306825,3529,,prevents,,Ketorolac,,,,Renal Colic,,,,, +23612322,3530,,prevents,,Ketorolac,,,,Chronic pain,,,,, +20717559,3531,,prevents,,Ketorolac,,,,injury,,,,, +11362007,3532,,prevents,,Ketorolac,,,,Back pain,,,,, +11361661,3533,,prevents,,Ketorolac,,,,Inflammation,,,,, +11043378,3534,,prevents,,Ketorolac,,,,Headache,,,,, +7985904,3535,,prevents,,Ketorolac,,,,Pain,,,,, +20028754,3536,,predisposes,,Ketorolac,,,,injury,,,,, +25929768,3537,,related to,,Sulfadiazine,,,,congenital toxoplasmosis,,,,, +16546748,3538,,related to,,Sulfadiazine,,,,chorioretinitis,,,,, +27660461,3539,,causes,,Sulfamethoxazole,,,,pneumonia,,,,, +24328685,3540,,causes,,Sulfamethoxazole,,,,kidney disorder,,,,, +14835537,3541,,affects,,Sulfamethoxazole,,,,cystic fibrosis,,,,, +12226918,3542,,affects,,Sulfamethoxazole,,,,ocular toxoplasmosis,,,,, +26634163,3543,,prevents,,Sulfamethoxazole,,,,bacterial infectious disease,,,,, +23781290,3544,,prevents,,Sulfamethoxazole,,,,Infection,,,,, +22185408,3545,,prevents,,Sulfamethoxazole,,,,pneumocystosis,,,,, +21716989,3546,,affects,,Glycyrrhizic acid,,,,osteoarthritis,,,,, +21716987,3547,,disrupts,,Glycyrrhizic acid,,,,osteoarthritis,,,,, +13246285,3548,,related to,,Ciclesonide,,,,perennial allergic rhinitis,,,,, +13246284,3549,,related to,,Ciclesonide,,,,seasonal allergic rhinitis,,,,, +10789097,3550,,related to,,Ciclesonide,,,,asthma,,,,, +13334776,3551,,causes,,Ciclesonide,,,,asthma,,,,, +13603690,3552,,affects,,Ciclesonide,,,,asthma,,,,, +26135729,3553,,related to,,Flunisolide,,,,perennial allergic rhinitis,,,,, +16438918,3554,,related to,,Flunisolide,,,,rhinitis,,,,, +7778368,3555,,related to,,Flunisolide,,,,asthma,,,,, +12189287,3556,,prevents,,Flunisolide,,,,Nasal congestion,,,,, +27725383,3557,,related to,,Etoposide,,,,hepatoblastoma,,,,, +27360363,3558,,related to,,Etoposide,,,,ependymoma,,,,, +27062931,3559,,related to,,Etoposide,,,,supratentorial primitive neuroectodermal tumor,,,,, +26965210,3560,,related to,,Etoposide,,,,kidney Wilms tumor,,,,, +26632944,3561,,related to,,Etoposide,,,,HIV infectious disease,,,,, +22727077,3562,,related to,,Etoposide,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +21142004,3563,,related to,,Etoposide,,,,AIDS,,,,, +20988037,3564,,related to,,Etoposide,,,,retinoblastoma,,,,, +20394132,3565,,related to,,Etoposide,,,,B-cell neoplasm,,,,, +19900770,3566,,related to,,Etoposide,,,,myelodysplastic syndrome,,,,, +18768176,3567,,related to,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, +17380085,3568,,related to,,Etoposide,,,,Kaposi's sarcoma,,,,, +17284305,3569,,related to,,Etoposide,,,,bone osteosarcoma,,,,, +17191209,3570,,related to,,Etoposide,,,,hepatocellular carcinoma,,,,, +17136035,3571,,related to,,Etoposide,,,,diffuse large B-cell lymphoma,,,,, +16406847,3572,,related to,,Etoposide,,,,neuroendocrine carcinoma,,,,, +16067960,3573,,related to,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, +15501025,3574,,related to,,Etoposide,,,,brain cancer,,,,, +15141728,3575,,related to,,Etoposide,,,,testicular cancer,,,,, +15031494,3576,,related to,,Etoposide,,,,lymphoid leukemia,,,,, +14511230,3577,,related to,,Etoposide,,,,glioblastoma,,,,, +14453465,3578,,related to,,Etoposide,,,,T-cell non-Hodgkin lymphoma,,,,, +13764189,3579,,related to,,Etoposide,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +12298091,3580,,related to,,Etoposide,,,,breast neoplasm,,,,, +11028194,3581,,related to,,Etoposide,,,,acute lymphoblastic leukemia,,,,, +10672040,3582,,related to,,Etoposide,,,,Ewing sarcoma,,,,, +10503115,3583,,related to,,Etoposide,,,,kidney cancer,,,,, +10441577,3584,,related to,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, +10410657,3585,,related to,,Etoposide,,,,neutropenia,,,,, +10182075,3586,,related to,,Etoposide,,,,non-Hodgkin lymphoma,,,,, +10161953,3587,,related to,,Etoposide,,,,squamous cell carcinoma,,,,, +9231982,3588,,related to,,Etoposide,,,,carcinoma,,,,, +9157972,3589,,related to,,Etoposide,,,,thymoma,,,,, +9138703,3590,,related to,,Etoposide,,,,ovarian cancer,,,,, +9115115,3591,,related to,,Etoposide,,,,sarcoma,,,,, +9024985,3592,,related to,,Etoposide,,,,leukemia,,,,, +9008448,3593,,related to,,Etoposide,,,,Hodgkins lymphoma,,,,, +9006645,3594,,related to,,Etoposide,,,,neuroblastoma,,,,, +8074798,3595,,related to,,Etoposide,,,,medulloblastoma,,,,, +8048523,3596,,related to,,Etoposide,,,,lymphoma,,,,, +7998504,3597,,related to,,Etoposide,,,,plasma cell myeloma,,,,, +7989979,3598,,related to,,Etoposide,,,,neoplasm,,,,, +7896801,3599,,related to,,Etoposide,,,,adult T-cell leukemia/lymphoma,,,,, +7845509,3600,,related to,,Etoposide,,,,glioma,,,,, +7810052,3601,,related to,,Etoposide,,,,castration-resistant prostate carcinoma,,,,, +7711547,3602,,related to,,Etoposide,,,,acute myeloid leukemia,,,,, +7319060,3603,,related to,,Etoposide,,,,small cell lung carcinoma,,,,, +7200681,3604,,related to,,Etoposide,,,,non-small cell lung carcinoma,,,,, +23328204,3605,,causes,,Etoposide,,,,small cell lung carcinoma,,,,, +12215704,3606,,causes,,Etoposide,,,,neoplasm,,,,, +8706370,3607,,causes,,Etoposide,,,,neutropenia,,,,, +7869845,3608,,causes,,Etoposide,,,,leukemia,,,,, +7642766,3609,,causes,,Etoposide,,,,acute myeloid leukemia,,,,, +27374335,3610,,affects,,Etoposide,,,,retinoblastoma,,,,, +26960810,3611,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, +25269562,3612,,affects,,Etoposide,,,,hemophagocytic syndrome,,,,, +23238600,3613,,affects,,Etoposide,,,,choriocarcinoma,,,,, +18166706,3614,,affects,,Etoposide,,,,neuroblastoma,,,,, +17967080,3615,,affects,,Etoposide,,,,leukemia,,,,, +17160632,3616,,affects,,Etoposide,,,,carcinoma,,,,, +16724406,3617,,affects,,Etoposide,,,,neoplasm,,,,, +16425822,3618,,affects,,Etoposide,,,,leukemia,,,,, +15965763,3619,,affects,,Etoposide,,,,testicular cancer,,,,, +12798395,3620,,affects,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, +11699750,3621,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, +11396769,3622,,affects,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, +9913818,3623,,affects,,Etoposide,,,,acute erythroid leukemia,,,,, +9397866,3624,,affects,,Etoposide,,,,fallopian tube neoplasm,,,,, +9293530,3625,,affects,,Etoposide,,,,carcinoid tumor,,,,, +8200378,3626,,affects,,Etoposide,,,,neoplasm,,,,, +8003315,3627,,affects,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, +7908520,3628,,affects,,Etoposide,,,,B-cell neoplasm,,,,, +24115005,3629,,disrupts,,Etoposide,,,,small cell lung carcinoma,,,,, +17149618,3630,,disrupts,,Etoposide,,,,hemophagocytic syndrome,,,,, +16511954,3631,,disrupts,,Etoposide,,,,glioblastoma,,,,, +16039903,3632,,disrupts,,Etoposide,,,,neoplasm,,,,, +14383828,3633,,disrupts,,Etoposide,,,,bone osteosarcoma,,,,, +9134229,3634,,prevents,,Etoposide,,,,neoplasm,,,,, +22634859,3635,,predisposes,,Etoposide,,,,neoplasm,,,,, +18673787,3636,,predisposes,,Etoposide,,,,brain cancer,,,,, +16345738,3637,,predisposes,,Etoposide,,,,myelodysplastic syndrome,,,,, +16345737,3638,,predisposes,,Etoposide,,,,acute myeloid leukemia,,,,, +10333072,3639,,predisposes,,Etoposide,,,,leukemia,,,,, +16677028,3640,,related to,,Teniposide,,,,neoplasm,,,,, +10688707,3641,,related to,,Teniposide,,,,lymphoma,,,,, +10688706,3642,,related to,,Teniposide,,,,leukemia,,,,, +27095076,3643,,affects,,Teniposide,,,,leukemia,,,,, +26849066,3644,,predisposes,,Teniposide,,,,leukemia,,,,, +18768362,3645,,related to,,Urofollitropin,,,,hypogonadism,,,,, +18095820,3646,,related to,,Urofollitropin,,,,primary ovarian failure,,,,, +9960851,3647,,related to,,Urofollitropin,,,,anovulation,,,,, +9716197,3648,,related to,,Urofollitropin,,,,female infertility,,,,, +8496709,3649,,related to,,Urofollitropin,,,,infertility disorder,,,,, +8454088,3650,,related to,,Urofollitropin,,,,male infertility,,,,, +8378642,3651,,related to,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +8205307,3652,,related to,,Urofollitropin,,,,azoospermia,,,,, +14878529,3653,,related to,,Urofollitropin,,,,female infertility,,,,, +9422493,3654,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +9422493,3655,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +10444908,3656,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +10444908,3657,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7103614,3658,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7103614,3659,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7302412,3660,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7606444,3661,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +21372974,3662,,causes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +16723493,3663,,causes,,Urofollitropin,,,,hypogonadism,,,,, +16322495,3664,,causes,,Urofollitropin,,,,azoospermia,,,,, +9453052,3665,,causes,,Urofollitropin,,,,primary ovarian failure,,,,, +8923757,3666,,causes,,Urofollitropin,,,,Pregnancy,,,,, +8815215,3667,,causes,,Urofollitropin,,,,anovulation,,,,, +8590972,3668,,causes,,Urofollitropin,,,,male infertility,,,,, +8270576,3669,,causes,,Urofollitropin,,,,infertility disorder,,,,, +19357829,3670,,affects,,Urofollitropin,,,,gonadal disorder,,,,, +15865492,3671,,affects,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +14984090,3672,,affects,,Urofollitropin,,,,male infertility,,,,, +13249247,3673,,affects,,Urofollitropin,,,,Pregnancy,,,,, +10980447,3674,,affects,,Urofollitropin,,,,Pregnancy,,,,, +8590971,3675,,affects,,Urofollitropin,,,,male infertility,,,,, +7302415,3676,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +9844029,3677,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +27587327,3678,,produces,,Urofollitropin,,,,primary ovarian failure,,,,, +20465917,3679,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +20465917,3680,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +8502213,3681,,produces,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +20569186,3682,,disrupts,,Urofollitropin,,,,Pregnancy,,,,, +11195885,3683,,prevents,,Urofollitropin,,,,azoospermia,,,,, +17502146,3684,,predisposes,,Urofollitropin,,,,azoospermia,,,,, +16417247,3685,,predisposes,,Urofollitropin,,,,anovulation,,,,, +16278695,3686,,predisposes,,Urofollitropin,,,,infertility disorder,,,,, +15110465,3687,,predisposes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +7379891,3688,,predisposes,,Urofollitropin,,,,primary ovarian failure,,,,, +23895216,3689,,affects,,Ivacaftor,,,,cystic fibrosis,,,,, +20354463,3690,,related to,,Nitric oxide,,,,ST-elevation myocardial infarction,,,,, +17273075,3691,,related to,,Nitric oxide,,,,bronchiolitis,,,,, +15880296,3692,,related to,,Nitric oxide,,,,Diabetic Foot,,,,, +14910010,3693,,related to,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, +14573099,3694,,related to,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, +11752178,3695,,related to,,Nitric oxide,,,,cutaneous leishmaniasis,,,,, +9816415,3696,,related to,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, +9774015,3697,,related to,,Nitric oxide,,,,respiratory system disorder,,,,, +8707490,3698,,related to,,Nitric oxide,,,,myocardial infarction,,,,, +8593326,3699,,related to,,Nitric oxide,,,,neuralgia,,,,, +8476870,3700,,related to,,Nitric oxide,,,,lung disorder,,,,, +8350800,3701,,related to,,Nitric oxide,,,,opiate dependence,,,,, +8343542,3702,,related to,,Nitric oxide,,,,Varicose Ulcer,,,,, +8057943,3703,,related to,,Nitric oxide,,,,malaria,,,,, +8040944,3704,,related to,,Nitric oxide,,,,sickle cell anemia,,,,, +7963930,3705,,related to,,Nitric oxide,,,,cystic fibrosis,,,,, +7923041,3706,,related to,,Nitric oxide,,,,brain injury,,,,, +7788094,3707,,related to,,Nitric oxide,,,,myocardial ischemia,,,,, +7738003,3708,,related to,,Nitric oxide,,,,Hypoxemia,,,,, +7725812,3709,,related to,,Nitric oxide,,,,Premature birth,,,,, +7657450,3710,,related to,,Nitric oxide,,,,pulmonary embolism,,,,, +7539810,3711,,related to,,Nitric oxide,,,,stroke disorder,,,,, +7481315,3712,,related to,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +7449413,3713,,related to,,Nitric oxide,,,,respiratory failure,,,,, +7439172,3714,,related to,,Nitric oxide,,,,neoplasm,,,,, +7418030,3715,,related to,,Nitric oxide,,,,acute kidney failure,,,,, +7373096,3716,,related to,,Nitric oxide,,,,brain ischemia,,,,, +7345317,3717,,related to,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, +7242606,3718,,related to,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +7159413,3719,,related to,,Nitric oxide,,,,Sepsis,,,,, +7145311,3720,,related to,,Nitric oxide,,,,Inflammation,,,,, +7091337,3721,,related to,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +14184908,3722,,related to,,Nitric oxide,,,,Inflammation,,,,, +27698007,3723,,causes,,Nitric oxide,,,,lung disorder,,,,, +23636922,3724,,causes,,Nitric oxide,,,,Infection,,,,, +22013082,3725,,causes,,Nitric oxide,,,,sickle cell anemia,,,,, +21447838,3726,,causes,,Nitric oxide,,,,respiratory system disorder,,,,, +14028136,3727,,causes,,Nitric oxide,,,,stroke disorder,,,,, +12046903,3728,,causes,,Nitric oxide,,,,cystic fibrosis,,,,, +11887505,3729,,causes,,Nitric oxide,,,,myocardial ischemia,,,,, +11842330,3730,,causes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +11556568,3731,,causes,,Nitric oxide,,,,acute kidney failure,,,,, +11353052,3732,,causes,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +9962165,3733,,causes,,Nitric oxide,,,,malaria,,,,, +9795722,3734,,causes,,Nitric oxide,,,,neuralgia,,,,, +9068211,3735,,causes,,Nitric oxide,,,,pneumonia,,,,, +8934561,3736,,causes,,Nitric oxide,,,,brain injury,,,,, +8855613,3737,,causes,,Nitric oxide,,,,neoplasm,,,,, +8834736,3738,,causes,,Nitric oxide,,,,myocardial infarction,,,,, +8346309,3739,,causes,,Nitric oxide,,,,Premature birth,,,,, +8185371,3740,,causes,,Nitric oxide,,,,Inflammation,,,,, +8037779,3741,,causes,,Nitric oxide,,,,brain ischemia,,,,, +7409857,3742,,causes,,Nitric oxide,,,,Sepsis,,,,, +7184490,3743,,causes,,Nitric oxide,,,,Hypoxemia,,,,, +27626134,3744,,affects,,Nitric oxide,,,,cystic fibrosis,,,,, +27208311,3745,,affects,,Nitric oxide,,,,opiate dependence,,,,, +27058878,3746,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, +20413999,3747,,affects,,Nitric oxide,,,,brain injury,,,,, +19764415,3748,,affects,,Nitric oxide,,,,pneumonia,,,,, +18632674,3749,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, +17798838,3750,,affects,,Nitric oxide,,,,neuralgia,,,,, +17030125,3751,,affects,,Nitric oxide,,,,bronchiolitis,,,,, +12566083,3752,,affects,,Nitric oxide,,,,respiratory system disorder,,,,, +11778681,3753,,affects,,Nitric oxide,,,,stroke disorder,,,,, +11521495,3754,,affects,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, +11353389,3755,,affects,,Nitric oxide,,,,myocardial infarction,,,,, +10403969,3756,,affects,,Nitric oxide,,,,anemia,,,,, +10222313,3757,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +10099288,3758,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, +10018002,3759,,affects,,Nitric oxide,,,,acute kidney failure,,,,, +10008267,3760,,affects,,Nitric oxide,,,,lung disorder,,,,, +9982988,3761,,affects,,Nitric oxide,,,,respiratory failure,,,,, +9910920,3762,,affects,,Nitric oxide,,,,brain ischemia,,,,, +9742582,3763,,affects,,Nitric oxide,,,,stroke disorder,,,,, +9649727,3764,,affects,,Nitric oxide,,,,neoplasm,,,,, +9102608,3765,,affects,,Nitric oxide,,,,Hypoxemia,,,,, +9095187,3766,,affects,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, +8891949,3767,,affects,,Nitric oxide,,,,Sepsis,,,,, +8832872,3768,,affects,,Nitric oxide,,,,pneumonia,,,,, +8646255,3769,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, +8473168,3770,,affects,,Nitric oxide,,,,neoplasm,,,,, +8202584,3771,,affects,,Nitric oxide,,,,Sepsis,,,,, +8139693,3772,,affects,,Nitric oxide,,,,brain injury,,,,, +7935763,3773,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +7896362,3774,,affects,,Nitric oxide,,,,Inflammation,,,,, +7780898,3775,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +7712088,3776,,affects,,Nitric oxide,,,,Hypoxemia,,,,, +7542916,3777,,affects,,Nitric oxide,,,,anemia,,,,, +7169788,3778,,affects,,Nitric oxide,,,,Inflammation,,,,, +7164340,3779,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +7094195,3780,,affects,,Nitric oxide,,,,malaria,,,,, +20359925,3781,,produces,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +20299429,3782,,produces,,Nitric oxide,,,,pneumonia,,,,, +17925357,3783,,produces,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, +15219259,3784,,produces,,Nitric oxide,,,,Premature birth,,,,, +13106727,3785,,produces,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +12774415,3786,,produces,,Nitric oxide,,,,stroke disorder,,,,, +12205025,3787,,produces,,Nitric oxide,,,,Varicose Ulcer,,,,, +11786457,3788,,produces,,Nitric oxide,,,,brain ischemia,,,,, +9816411,3789,,produces,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, +8745644,3790,,produces,,Nitric oxide,,,,sickle cell anemia,,,,, +8339020,3791,,produces,,Nitric oxide,,,,acute kidney failure,,,,, +7963932,3792,,produces,,Nitric oxide,,,,cystic fibrosis,,,,, +7644756,3793,,produces,,Nitric oxide,,,,anemia,,,,, +7555266,3794,,produces,,Nitric oxide,,,,myocardial ischemia,,,,, +7511323,3795,,produces,,Nitric oxide,,,,myocardial infarction,,,,, +7507297,3796,,produces,,Nitric oxide,,,,Inflammation,,,,, +7461061,3797,,produces,,Nitric oxide,,,,Hypoxemia,,,,, +7435212,3798,,produces,,Nitric oxide,,,,neoplasm,,,,, +7390889,3799,,produces,,Nitric oxide,,,,Sepsis,,,,, +7094197,3800,,produces,,Nitric oxide,,,,malaria,,,,, +26705109,3801,,disrupts,,Nitric oxide,,,,anemia,,,,, +19923810,3802,,disrupts,,Nitric oxide,,,,stroke disorder,,,,, +14786185,3803,,disrupts,,Nitric oxide,,,,Sepsis,,,,, +12247489,3804,,disrupts,,Nitric oxide,,,,sickle cell anemia,,,,, +11088644,3805,,disrupts,,Nitric oxide,,,,cystic fibrosis,,,,, +10963665,3806,,disrupts,,Nitric oxide,,,,neoplasm,,,,, +10158293,3807,,disrupts,,Nitric oxide,,,,myocardial ischemia,,,,, +9091818,3808,,disrupts,,Nitric oxide,,,,respiratory failure,,,,, +8577648,3809,,disrupts,,Nitric oxide,,,,Inflammation,,,,, +7822328,3810,,disrupts,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +7750750,3811,,disrupts,,Nitric oxide,,,,myocardial infarction,,,,, +7555296,3812,,disrupts,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +7358959,3813,,disrupts,,Nitric oxide,,,,Hypoxemia,,,,, +26913950,3814,,prevents,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +25277893,3815,,prevents,,Nitric oxide,,,,neuralgia,,,,, +22898445,3816,,prevents,,Nitric oxide,,,,Infection,,,,, +21669107,3817,,prevents,,Nitric oxide,,,,neoplasm,,,,, +21628822,3818,,prevents,,Nitric oxide,,,,Hypoxemia,,,,, +21494876,3819,,prevents,,Nitric oxide,,,,Inflammation,,,,, +21062009,3820,,prevents,,Nitric oxide,,,,pulmonary embolism,,,,, +16675253,3821,,prevents,,Nitric oxide,,,,stroke disorder,,,,, +13634130,3822,,prevents,,Nitric oxide,,,,sickle cell anemia,,,,, +11584828,3823,,prevents,,Nitric oxide,,,,brain ischemia,,,,, +11450951,3824,,prevents,,Nitric oxide,,,,myocardial infarction,,,,, +10887585,3825,,prevents,,Nitric oxide,,,,pneumonia,,,,, +9990816,3826,,prevents,,Nitric oxide,,,,acute kidney failure,,,,, +9464831,3827,,prevents,,Nitric oxide,,,,myocardial ischemia,,,,, +8988568,3828,,prevents,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +8396830,3829,,prevents,,Nitric oxide,,,,cystic fibrosis,,,,, +8224065,3830,,prevents,,Nitric oxide,,,,brain injury,,,,, +8045867,3831,,prevents,,Nitric oxide,,,,lung disorder,,,,, +7996843,3832,,prevents,,Nitric oxide,,,,Sepsis,,,,, +7713281,3833,,prevents,,Nitric oxide,,,,respiratory failure,,,,, +7103253,3834,,prevents,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +27558971,3835,,exacerbates,,Nitric oxide,,,,myocardial ischemia,,,,, +26883794,3836,,exacerbates,,Nitric oxide,,,,acute kidney failure,,,,, +24530593,3837,,exacerbates,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +23305196,3838,,predisposes,,Nitric oxide,,,,cystic fibrosis,,,,, +18515843,3839,,predisposes,,Nitric oxide,,,,malaria,,,,, +17339126,3840,,predisposes,,Nitric oxide,,,,stroke disorder,,,,, +17303048,3841,,predisposes,,Nitric oxide,,,,brain ischemia,,,,, +16438716,3842,,predisposes,,Nitric oxide,,,,respiratory system disorder,,,,, +16061041,3843,,predisposes,,Nitric oxide,,,,lung disorder,,,,, +15696584,3844,,predisposes,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +13236015,3845,,predisposes,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, +12163328,3846,,predisposes,,Nitric oxide,,,,acute kidney failure,,,,, +12068938,3847,,predisposes,,Nitric oxide,,,,neuralgia,,,,, +11569688,3848,,predisposes,,Nitric oxide,,,,Premature birth,,,,, +9326529,3849,,predisposes,,Nitric oxide,,,,brain injury,,,,, +8098085,3850,,predisposes,,Nitric oxide,,,,neoplasm,,,,, +7895713,3851,,predisposes,,Nitric oxide,,,,pneumonia,,,,, +7863118,3852,,predisposes,,Nitric oxide,,,,Hypoxemia,,,,, +7644760,3853,,predisposes,,Nitric oxide,,,,anemia,,,,, +7373094,3854,,predisposes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +7119398,3855,,predisposes,,Nitric oxide,,,,Inflammation,,,,, +18948956,3856,,related to,,CHORIOGONADOTROPIN ALFA,,,,ovarian hyperstimulation syndrome,,,,, +10437081,3857,,related to,,CHORIONIC GONADOTROPIN,,,,hypogonadism,,,,, +10427260,3858,,related to,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, +25953720,3859,,causes,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, +12680602,3860,,causes,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +19382665,3861,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +10661395,3862,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +11878666,3863,,produces,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +19257969,3864,,causes,,Triclosan,,,,allergic disease,,,,, +17886883,3865,,affects,,Triclosan,,,,gingivitis,,,,, +9651026,3866,,disrupts,,Triclosan,,,,gingivitis,,,,, +16053270,3867,,prevents,,Triclosan,,,,allergic disease,,,,, +20585436,3868,,affects,,Povidone iodine,,,,stomatitis,,,,, +22182083,3869,,prevents,,Povidone iodine,,,,Infection,,,,, +22061199,3870,,prevents,,Povidone iodine,,,,dental caries,,,,, +20053240,3871,,prevents,,Povidone iodine,,,,keratitis,,,,, +25268747,3872,,related to,,Vinblastine,,,,acute myeloid leukemia,,,,, +24601120,3873,,related to,,Vinblastine,,,,leukemia,,,,, +17518639,3874,,related to,,Vinblastine,,,,testicular cancer,,,,, +11295996,3875,,related to,,Vinblastine,,,,melanoma,,,,, +10629211,3876,,related to,,Vinblastine,,,,castration-resistant prostate carcinoma,,,,, +9405598,3877,,related to,,Vinblastine,,,,glioma,,,,, +8887641,3878,,related to,,Vinblastine,,,,neoplasm,,,,, +8831546,3879,,related to,,Vinblastine,,,,renal cell carcinoma,,,,, +8248825,3880,,related to,,Vinblastine,,,,lymphoma,,,,, +8201846,3881,,related to,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, +7111310,3882,,related to,,Vinblastine,,,,Hodgkins lymphoma,,,,, +22913920,3883,,causes,,Vinblastine,,,,neoplasm,,,,, +14498052,3884,,affects,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, +12889760,3885,,affects,,Vinblastine,,,,renal cell carcinoma,,,,, +11723511,3886,,affects,,Vinblastine,,,,neoplasm,,,,, +19032862,3887,,disrupts,,Vinblastine,,,,neoplasm,,,,, +26195658,3888,,related to,,Desacetylvinblastine amide,,,,lymphoma,,,,, +26116904,3889,,related to,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, +25980030,3890,,related to,,Desacetylvinblastine amide,,,,small cell lung carcinoma,,,,, +26313629,3891,,affects,,Desacetylvinblastine amide,,,,neoplasm,,,,, +26201212,3892,,affects,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, +26302410,3893,,prevents,,Desacetylvinblastine amide,,,,neoplasm,,,,, +25951740,3894,,causes,,Diazoxide,,,,hyperinsulinism,,,,, +17059197,3895,,causes,,Diazoxide,,,,hypoglycemia,,,,, +25817473,3896,,affects,,Diazoxide,,,,hypertensive disorder,,,,, +20202762,3897,,affects,,Diazoxide,,,,obesity disorder,,,,, +11393233,3898,,affects,,Diazoxide,,,,hyperinsulinism,,,,, +8184004,3899,,affects,,Diazoxide,,,,hypoglycemia,,,,, +9572369,3900,,disrupts,,Diazoxide,,,,hyperinsulinism,,,,, +26286810,3901,,prevents,,Diazoxide,,,,hypoglycemia,,,,, +22404640,3902,,prevents,,Diazoxide,,,,hypertensive disorder,,,,, +19200973,3903,,prevents,,Diazoxide,,,,obesity disorder,,,,, +16737667,3904,,predisposes,,Diazoxide,,,,hypoglycemia,,,,, +14267417,3905,,affects,,Pantoprazole,,,,gastroesophageal reflux disease,,,,, +12160514,3906,,prevents,,Pantoprazole,,,,active peptic ulcer disease,,,,, +8423273,3907,,prevents,,Pantoprazole,,,,peptic ulcer disease,,,,, +7509578,3908,,prevents,,Pantoprazole,,,,ulcer disease,,,,, +21088628,3909,,predisposes,,Pantoprazole,,,,active peptic ulcer disease,,,,, +20047688,3910,,causes,,Lansoprazole,,,,gastric ulcer,,,,, +26544602,3911,,affects,,Lansoprazole,,,,peptic ulcer disease,,,,, +11547923,3912,,affects,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +10008124,3913,,affects,,Lansoprazole,,,,peptic esophagitis,,,,, +7314434,3914,,affects,,Lansoprazole,,,,Helicobacter pylori infectious disease,,,,, +9466998,3915,,disrupts,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +20033093,3916,,prevents,,Lansoprazole,,,,peptic ulcer disease,,,,, +15339719,3917,,prevents,,Lansoprazole,,,,duodenal ulcer,,,,, +9335785,3918,,prevents,,Lansoprazole,,,,gastric ulcer,,,,, +8183428,3919,,prevents,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +27664803,3920,,exacerbates,,Lansoprazole,,,,gastritis,,,,, +10008126,3921,,predisposes,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +10345128,3922,,subclass of,,Omeprazole,,,,Omeprazole sulfone,,,,, +8512321,3923,,subclass of,,Omeprazole,,,,Hydroxyomeprazole,,,,, +27115212,3924,,related to,,Omeprazole,,,,Omeprazole sulfone,,,,, +12365583,3925,,related to,,Omeprazole,,,,gastric ulcer,,,,, +7744216,3926,,related to,,Omeprazole,,,,Hydroxyomeprazole,,,,, +26722672,3927,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, +9932953,3928,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, +22198908,3929,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, +13085286,3930,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, +27703677,3931,,causes,,Omeprazole,,,,anemia,,,,, +27298440,3932,,causes,,Omeprazole,,,,Hemorrhage,,,,, +24514538,3933,,causes,,Omeprazole,,,,peptic ulcer disease,,,,, +19641302,3934,,causes,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +15956000,3935,,causes,,Omeprazole,,,,esophagitis,,,,, +12187782,3936,,causes,,Omeprazole,,,,ulcer disease,,,,, +11135889,3937,,causes,,Omeprazole,,,,injury,,,,, +10813876,3938,,causes,,Omeprazole,,,,Cough,,,,, +8871402,3939,,causes,,Omeprazole,,,,gastric ulcer,,,,, +7272148,3940,,causes,,Omeprazole,,,,duodenal ulcer,,,,, +27758339,3941,,affects,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, +27758338,3942,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, +27758337,3943,,affects,,Omeprazole,,,,peptic esophagitis,,,,, +27733079,3944,,affects,,Omeprazole,,,,peptic esophagitis,,,,, +27346919,3945,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, +22440533,3946,,affects,,Omeprazole,,,,anemia,,,,, +18634760,3947,,affects,,Omeprazole,,,,Pain,,,,, +17967745,3948,,affects,,Omeprazole,,,,injury,,,,, +12114858,3949,,affects,,Omeprazole,,,,ulcer disease,,,,, +11576921,3950,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, +10321262,3951,,affects,,Omeprazole,,,,duodenal ulcer,,,,, +9976497,3952,,affects,,Omeprazole,,,,gastric ulcer,,,,, +8694897,3953,,affects,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, +8349380,3954,,affects,,Omeprazole,,,,Hemorrhage,,,,, +8349375,3955,,affects,,Omeprazole,,,,Hemorrhage,,,,, +7653505,3956,,affects,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +7572363,3957,,affects,,Omeprazole,,,,ulcer disease,,,,, +14345083,3958,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, +26726289,3959,,disrupts,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +26000029,3960,,disrupts,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, +20129793,3961,,disrupts,,Omeprazole,,,,Barrett esophagus,,,,, +19299462,3962,,disrupts,,Omeprazole,,,,active peptic ulcer disease,,,,, +15524012,3963,,disrupts,,Omeprazole,,,,peptic ulcer disease,,,,, +13078646,3964,,disrupts,,Omeprazole,,,,ulcer disease,,,,, +10891179,3965,,disrupts,,Omeprazole,,,,gastric ulcer,,,,, +10776897,3966,,disrupts,,Omeprazole,,,,duodenal ulcer,,,,, +8884340,3967,,disrupts,,Omeprazole,,,,esophagitis,,,,, +27690262,3968,,prevents,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, +27025148,3969,,prevents,,Omeprazole,,,,Cough,,,,, +26715213,3970,,prevents,,Omeprazole,,,,Pain,,,,, +16929638,3971,,prevents,,Omeprazole,,,,esophagitis,,,,, +15601042,3972,,prevents,,Omeprazole,,,,active peptic ulcer disease,,,,, +9292674,3973,,prevents,,Omeprazole,,,,peptic ulcer disease,,,,, +8884338,3974,,prevents,,Omeprazole,,,,peptic esophagitis,,,,, +8341772,3975,,prevents,,Omeprazole,,,,duodenal ulcer,,,,, +8169375,3976,,prevents,,Omeprazole,,,,injury,,,,, +7646984,3977,,prevents,,Omeprazole,,,,gastric ulcer,,,,, +7653510,3978,,prevents,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +7332307,3979,,prevents,,Omeprazole,,,,ulcer disease,,,,, +24752030,3980,,predisposes,,Omeprazole,,,,type 2 diabetes mellitus,,,,, +21309680,3981,,predisposes,,Omeprazole,,,,melanoma,,,,, +20838741,3982,,predisposes,,Omeprazole,,,,Barrett esophagus,,,,, +12649375,3983,,affects,,Rabeprazole,,,,infectious disease,,,,, +11547924,3984,,affects,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, +15461842,3985,,disrupts,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, +16244495,3986,,prevents,,Rabeprazole,,,,peptic ulcer disease,,,,, +15354267,3987,,prevents,,Rabeprazole,,,,active peptic ulcer disease,,,,, +8397732,3988,,prevents,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, +23526790,3989,,causes,,Esomeprazole,,,,active peptic ulcer disease,,,,, +20333475,3990,,causes,,Esomeprazole,,,,preeclampsia,,,,, +15271081,3991,,causes,,Esomeprazole,,,,gastric ulcer,,,,, +22638872,3992,,affects,,Esomeprazole,,,,neoplasm,,,,, +20180848,3993,,affects,,Esomeprazole,,,,preeclampsia,,,,, +19360632,3994,,affects,,Esomeprazole,,,,ulcer disease,,,,, +18357402,3995,,affects,,Esomeprazole,,,,dyspepsia,,,,, +14247859,3996,,affects,,Esomeprazole,,,,gastric ulcer,,,,, +12902689,3997,,affects,,Esomeprazole,,,,Hemorrhage,,,,, +12902688,3998,,affects,,Esomeprazole,,,,Hemorrhage,,,,, +12527967,3999,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +12015567,4000,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +10805094,4001,,disrupts,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +15938697,4002,,prevents,,Esomeprazole,,,,gastric ulcer,,,,, +14015294,4003,,prevents,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +13576722,4004,,prevents,,Esomeprazole,,,,peptic ulcer disease,,,,, +12321750,4005,,prevents,,Esomeprazole,,,,ulcer disease,,,,, +10396538,4006,,related to,,Roflumilast,,,,asthma,,,,, +21017284,4007,,causes,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, +21116198,4008,,affects,,Roflumilast,,,,obesity disorder,,,,, +12290110,4009,,affects,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, +12290109,4010,,affects,,Roflumilast,,,,asthma,,,,, +22432515,4011,,disrupts,,Roflumilast,,,,schizophrenia,,,,, +24502817,4012,,prevents,,Roflumilast,,,,obesity disorder,,,,, +17763098,4013,,prevents,,Roflumilast,,,,diabetic kidney disease,,,,, +15955656,4014,,prevents,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, +8310806,4015,,causes,,Meperidine,,,,Pain,,,,, +26434893,4016,,affects,,Meperidine,,,,Pain,,,,, +18658715,4017,,affects,,Meperidine,,,,Pain,,,,, +8345324,4018,,prevents,,Meperidine,,,,Pain,,,,, +21672389,4019,,affects,,Ketobemidone,,,,Pain,,,,, +11850764,4020,,related to,,Travoprost,,,,ocular hypertension,,,,, +12116829,4021,,physically interacts with,,Travoprost,,,,prostanoid FP receptor,,,,, +18294152,4022,,affects,,Travoprost,,,,ocular hypertension,,,,, +18294151,4023,,affects,,Travoprost,,,,glaucoma,,,,, +10166996,4024,,prevents,,Travoprost,,,,ocular hypertension,,,,, +10166995,4025,,prevents,,Travoprost,,,,open-angle glaucoma,,,,, +17904574,4026,,related to,,Tafluprost,,,,glaucoma,,,,, +15304153,4027,,related to,,Tafluprost,,,,ocular hypertension,,,,, +15304152,4028,,related to,,Tafluprost,,,,open-angle glaucoma,,,,, +14941475,4029,,physically interacts with,,Tafluprost,,,,prostanoid FP receptor,,,,, +14941474,4030,,disrupts,,Tafluprost,,,,ocular hypertension,,,,, +14941473,4031,,disrupts,,Tafluprost,,,,open-angle glaucoma,,,,, +14231277,4032,,affects,,Ramelteon,,,,insomnia,,,,, +21718213,4033,,prevents,,Ramelteon,,,,sleep-wake disorder,,,,, +22873470,4034,,related to,,Melatonin,,,,acute kidney failure,,,,, +22002909,4035,,related to,,Melatonin,,,,metabolic disease,,,,, +21777340,4036,,related to,,Melatonin,,,,Cognitive impairment,,,,, +18920431,4037,,related to,,Melatonin,,,,burn,,,,, +18846352,4038,,related to,,Melatonin,,,,skin disorder,,,,, +18613354,4039,,related to,,Melatonin,,,,Neonatal sepsis,,,,, +18189253,4040,,related to,,Melatonin,,,,necrotizing enterocolitis,,,,, +17471678,4041,,related to,,Melatonin,,,,"dermatitis, atopic",,,,, +17103445,4042,,related to,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, +16423098,4043,,related to,,Melatonin,,,,periodontitis,,,,, +16022569,4044,,related to,,Melatonin,,,,metabolic syndrome X,,,,, +15882605,4045,,related to,,Melatonin,,,,enuresis,,,,, +15709123,4046,,related to,,Melatonin,,,,fibromyalgia,,,,, +15665905,4047,,related to,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, +14933527,4048,,related to,,Melatonin,,,,autism spectrum disorder,,,,, +14875890,4049,,related to,,Melatonin,,,,pervasive developmental disorder,,,,, +14786958,4050,,related to,,Melatonin,,,,gastroesophageal reflux disease,,,,, +13857052,4051,,related to,,Melatonin,,,,ulcerative colitis,,,,, +13491215,4052,,related to,,Melatonin,,,,diabetes mellitus,,,,, +13407170,4053,,related to,,Melatonin,,,,periodontal disorder,,,,, +13365823,4054,,related to,,Melatonin,,,,tooth disorder,,,,, +12843346,4055,,related to,,Melatonin,,,,melanoma,,,,, +12132104,4056,,related to,,Melatonin,,,,irritable bowel syndrome,,,,, +11584899,4057,,related to,,Melatonin,,,,brain ischemia,,,,, +11533403,4058,,related to,,Melatonin,,,,hypertensive disorder,,,,, +11319171,4059,,related to,,Melatonin,,,,Pain,,,,, +11137637,4060,,related to,,Melatonin,,,,essential hypertension,,,,, +10685850,4061,,related to,,Melatonin,,,,major depressive disorder,,,,, +10528037,4062,,related to,,Melatonin,,,,multiple sclerosis,,,,, +10477010,4063,,related to,,Melatonin,,,,non-small cell lung carcinoma,,,,, +10371972,4064,,related to,,Melatonin,,,,delirium,,,,, +10204563,4065,,related to,,Melatonin,,,,depressive disorder,,,,, +9947492,4066,,related to,,Melatonin,,,,myocardial infarction,,,,, +9516882,4067,,related to,,Melatonin,,,,Parkinson disease,,,,, +9086006,4068,,related to,,Melatonin,,,,ischemia reperfusion injury,,,,, +9074687,4069,,related to,,Melatonin,,,,Sepsis,,,,, +8867365,4070,,related to,,Melatonin,,,,schizophrenia,,,,, +8780387,4071,,related to,,Melatonin,,,,insomnia,,,,, +8686098,4072,,related to,,Melatonin,,,,dementia,,,,, +8623112,4073,,related to,,Melatonin,,,,migraine disorder,,,,, +7795396,4074,,related to,,Melatonin,,,,injury,,,,, +7482169,4075,,related to,,Melatonin,,,,neoplasm,,,,, +7440685,4076,,related to,,Melatonin,,,,Fatigue,,,,, +7185935,4077,,related to,,Melatonin,,,,epilepsy,,,,, +7185921,4078,,related to,,Melatonin,,,,sleep-wake disorder,,,,, +26987553,4079,,causes,,Melatonin,,,,Fatigue,,,,, +24500836,4080,,causes,,Melatonin,,,,anxiety,,,,, +22662368,4081,,causes,,Melatonin,,,,dementia,,,,, +21258564,4082,,causes,,Melatonin,,,,multiple sclerosis,,,,, +19886996,4083,,causes,,Melatonin,,,,Cognitive impairment,,,,, +19573910,4084,,causes,,Melatonin,,,,periodontitis,,,,, +17837306,4085,,causes,,Melatonin,,,,metabolic disease,,,,, +17714427,4086,,causes,,Melatonin,,,,myocardial infarction,,,,, +16705153,4087,,causes,,Melatonin,,,,Sepsis,,,,, +15644359,4088,,causes,,Melatonin,,,,gastroesophageal reflux disease,,,,, +14831403,4089,,causes,,Melatonin,,,,periodontal disorder,,,,, +14171289,4090,,causes,,Melatonin,,,,Parkinson disease,,,,, +14078373,4091,,causes,,Melatonin,,,,hypertensive disorder,,,,, +13896033,4092,,causes,,Melatonin,,,,breast neoplasm,,,,, +13361926,4093,,causes,,Melatonin,,,,ischemia reperfusion injury,,,,, +13039360,4094,,causes,,Melatonin,,,,epilepsy,,,,, +12762592,4095,,causes,,Melatonin,,,,enuresis,,,,, +12275569,4096,,causes,,Melatonin,,,,diabetes mellitus,,,,, +12071557,4097,,causes,,Melatonin,,,,insomnia,,,,, +10432083,4098,,causes,,Melatonin,,,,migraine disorder,,,,, +10432067,4099,,causes,,Melatonin,,,,schizophrenia,,,,, +9114525,4100,,causes,,Melatonin,,,,neoplasm,,,,, +8785660,4101,,causes,,Melatonin,,,,depressive disorder,,,,, +8291971,4102,,causes,,Melatonin,,,,injury,,,,, +25620630,4103,,affects,,Melatonin,,,,Fatigue,,,,, +25259613,4104,,affects,,Melatonin,,,,atrial fibrillation,,,,, +24144792,4105,,affects,,Melatonin,,,,myocardial infarction,,,,, +24094187,4106,,affects,,Melatonin,,,,major depressive disorder,,,,, +23101890,4107,,affects,,Melatonin,,,,periodontitis,,,,, +22037016,4108,,affects,,Melatonin,,,,diabetes mellitus,,,,, +21523229,4109,,affects,,Melatonin,,,,anxiety,,,,, +21046382,4110,,affects,,Melatonin,,,,non-small cell lung carcinoma,,,,, +20888328,4111,,affects,,Melatonin,,,,autism spectrum disorder,,,,, +18858036,4112,,affects,,Melatonin,,,,Cognitive impairment,,,,, +18703578,4113,,affects,,Melatonin,,,,Marchiafava-Bignami disease,,,,, +18605461,4114,,affects,,Melatonin,,,,Neonatal sepsis,,,,, +18605459,4115,,affects,,Melatonin,,,,Neonatal sepsis,,,,, +18111864,4116,,affects,,Melatonin,,,,Hemorrhage,,,,, +17774103,4117,,affects,,Melatonin,,,,fibromyalgia,,,,, +17471677,4118,,affects,,Melatonin,,,,"dermatitis, atopic",,,,, +17402992,4119,,affects,,Melatonin,,,,Fatigue,,,,, +17199486,4120,,affects,,Melatonin,,,,Sepsis,,,,, +17103446,4121,,affects,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, +17112614,4122,,affects,,Melatonin,,,,ulcerative colitis,,,,, +16898660,4123,,affects,,Melatonin,,,,Cognitive impairment,,,,, +16300651,4124,,affects,,Melatonin,,,,depressive disorder,,,,, +16293202,4125,,affects,,Melatonin,,,,Hemorrhage,,,,, +16189615,4126,,affects,,Melatonin,,,,Cognitive impairment,,,,, +15390003,4127,,affects,,Melatonin,,,,delirium,,,,, +14400565,4128,,affects,,Melatonin,,,,burn,,,,, +14333232,4129,,affects,,Melatonin,,,,schizophrenia,,,,, +13430046,4130,,affects,,Melatonin,,,,epilepsy,,,,, +13158859,4131,,affects,,Melatonin,,,,tooth disorder,,,,, +12620684,4132,,affects,,Melatonin,,,,melanoma,,,,, +12473519,4133,,affects,,Melatonin,,,,Parkinson disease,,,,, +11739216,4134,,affects,,Melatonin,,,,sleep-wake disorder,,,,, +11451669,4135,,affects,,Melatonin,,,,depressive disorder,,,,, +10979770,4136,,affects,,Melatonin,,,,insomnia,,,,, +10516034,4137,,affects,,Melatonin,,,,Pain,,,,, +10432086,4138,,affects,,Melatonin,,,,multiple sclerosis,,,,, +10047665,4139,,affects,,Melatonin,,,,hypertensive disorder,,,,, +9535418,4140,,affects,,Melatonin,,,,injury,,,,, +9364224,4141,,affects,,Melatonin,,,,Pain,,,,, +9244581,4142,,affects,,Melatonin,,,,migraine disorder,,,,, +9153135,4143,,affects,,Melatonin,,,,diabetes mellitus,,,,, +9143737,4144,,affects,,Melatonin,,,,epilepsy,,,,, +9114510,4145,,affects,,Melatonin,,,,ischemia reperfusion injury,,,,, +8993003,4146,,affects,,Melatonin,,,,neoplasm,,,,, +8720758,4147,,affects,,Melatonin,,,,breast neoplasm,,,,, +8108047,4148,,affects,,Melatonin,,,,depressive disorder,,,,, +7564928,4149,,affects,,Melatonin,,,,neoplasm,,,,, +7382212,4150,,affects,,Melatonin,,,,brain ischemia,,,,, +26765396,4151,,produces,,Melatonin,,,,epilepsy,,,,, +22867260,4152,,produces,,Melatonin,,,,diabetes mellitus,,,,, +18240585,4153,,produces,,Melatonin,,,,ulcerative colitis,,,,, +17207380,4154,,produces,,Melatonin,,,,autism spectrum disorder,,,,, +17051558,4155,,produces,,Melatonin,,,,depressive disorder,,,,, +16192357,4156,,produces,,Melatonin,,,,sleep-wake disorder,,,,, +13817260,4157,,produces,,Melatonin,,,,Parkinson disease,,,,, +11388402,4158,,produces,,Melatonin,,,,neoplasm,,,,, +9153153,4159,,produces,,Melatonin,,,,hypertensive disorder,,,,, +8191029,4160,,produces,,Melatonin,,,,breast neoplasm,,,,, +24623673,4161,,disrupts,,Melatonin,,,,atrial fibrillation,,,,, +24220852,4162,,disrupts,,Melatonin,,,,metabolic disease,,,,, +22817547,4163,,disrupts,,Melatonin,,,,anxiety,,,,, +20966258,4164,,disrupts,,Melatonin,,,,Cognitive impairment,,,,, +20623050,4165,,disrupts,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, +19958338,4166,,disrupts,,Melatonin,,,,multiple sclerosis,,,,, +18007482,4167,,disrupts,,Melatonin,,,,Sepsis,,,,, +18002672,4168,,disrupts,,Melatonin,,,,Pain,,,,, +16753621,4169,,disrupts,,Melatonin,,,,sleep-wake disorder,,,,, +14914180,4170,,disrupts,,Melatonin,,,,melanoma,,,,, +14617999,4171,,disrupts,,Melatonin,,,,"dermatitis, atopic",,,,, +13855513,4172,,disrupts,,Melatonin,,,,Hemorrhage,,,,, +10721769,4173,,disrupts,,Melatonin,,,,depressive disorder,,,,, +10333555,4174,,disrupts,,Melatonin,,,,injury,,,,, +10294227,4175,,disrupts,,Melatonin,,,,breast neoplasm,,,,, +10070181,4176,,disrupts,,Melatonin,,,,brain ischemia,,,,, +10008170,4177,,disrupts,,Melatonin,,,,Marchiafava-Bignami disease,,,,, +8932328,4178,,disrupts,,Melatonin,,,,epilepsy,,,,, +7916082,4179,,disrupts,,Melatonin,,,,ischemia reperfusion injury,,,,, +7545973,4180,,disrupts,,Melatonin,,,,neoplasm,,,,, +24902716,4181,,prevents,,Melatonin,,,,stomatitis,,,,, +24687342,4182,,prevents,,Melatonin,,,,essential hypertension,,,,, +24623674,4183,,prevents,,Melatonin,,,,atrial fibrillation,,,,, +24368351,4184,,prevents,,Melatonin,,,,acute kidney failure,,,,, +23824121,4185,,prevents,,Melatonin,,,,dementia,,,,, +23122960,4186,,prevents,,Melatonin,,,,Cognitive impairment,,,,, +22817548,4187,,prevents,,Melatonin,,,,anxiety,,,,, +21718214,4188,,prevents,,Melatonin,,,,sleep-wake disorder,,,,, +20260777,4189,,prevents,,Melatonin,,,,Pain,,,,, +19640170,4190,,prevents,,Melatonin,,,,aortic aneurysm,,,,, +18396849,4191,,prevents,,Melatonin,,,,Sepsis,,,,, +18141997,4192,,prevents,,Melatonin,,,,metabolic disease,,,,, +16995162,4193,,prevents,,Melatonin,,,,metabolic syndrome X,,,,, +16549748,4194,,prevents,,Melatonin,,,,burn,,,,, +16245777,4195,,prevents,,Melatonin,,,,schizophrenia,,,,, +16232642,4196,,prevents,,Melatonin,,,,Marchiafava-Bignami disease,,,,, +15150085,4197,,prevents,,Melatonin,,,,depressive disorder,,,,, +14373042,4198,,prevents,,Melatonin,,,,Parkinson disease,,,,, +11616466,4199,,prevents,,Melatonin,,,,autism spectrum disorder,,,,, +11366467,4200,,prevents,,Melatonin,,,,migraine disorder,,,,, +11108260,4201,,prevents,,Melatonin,,,,hypertensive disorder,,,,, +11061121,4202,,prevents,,Melatonin,,,,insomnia,,,,, +10234923,4203,,prevents,,Melatonin,,,,breast neoplasm,,,,, +10127047,4204,,prevents,,Melatonin,,,,myocardial infarction,,,,, +9561452,4205,,prevents,,Melatonin,,,,diabetes mellitus,,,,, +9346845,4206,,prevents,,Melatonin,,,,delirium,,,,, +9336280,4207,,prevents,,Melatonin,,,,brain ischemia,,,,, +8678642,4208,,prevents,,Melatonin,,,,epilepsy,,,,, +8166782,4209,,prevents,,Melatonin,,,,ischemia reperfusion injury,,,,, +7622774,4210,,prevents,,Melatonin,,,,injury,,,,, +7545974,4211,,prevents,,Melatonin,,,,neoplasm,,,,, +19276524,4212,,exacerbates,,Melatonin,,,,diabetes mellitus,,,,, +7980097,4213,,exacerbates,,Melatonin,,,,brain ischemia,,,,, +27283551,4214,,predisposes,,Melatonin,,,,hypertensive disorder,,,,, +23266236,4215,,predisposes,,Melatonin,,,,epilepsy,,,,, +21026194,4216,,predisposes,,Melatonin,,,,migraine disorder,,,,, +20835242,4217,,predisposes,,Melatonin,,,,metabolic syndrome X,,,,, +20419573,4218,,predisposes,,Melatonin,,,,major depressive disorder,,,,, +19382519,4219,,predisposes,,Melatonin,,,,periodontal disorder,,,,, +18749948,4220,,predisposes,,Melatonin,,,,autism spectrum disorder,,,,, +18605458,4221,,predisposes,,Melatonin,,,,Neonatal sepsis,,,,, +18359560,4222,,predisposes,,Melatonin,,,,depressive disorder,,,,, +16852096,4223,,predisposes,,Melatonin,,,,diabetes mellitus,,,,, +15094135,4224,,predisposes,,Melatonin,,,,injury,,,,, +14875892,4225,,predisposes,,Melatonin,,,,pervasive developmental disorder,,,,, +11794031,4226,,predisposes,,Melatonin,,,,neoplasm,,,,, +11643546,4227,,predisposes,,Melatonin,,,,dementia,,,,, +10915746,4228,,predisposes,,Melatonin,,,,sleep-wake disorder,,,,, +10114913,4229,,predisposes,,Melatonin,,,,myocardial infarction,,,,, +12950718,4230,,related to,,RETEPLASE,,,,thrombotic disease,,,,, +7082056,4231,,related to,,RETEPLASE,,,,stroke disorder,,,,, +12026281,4232,,related to,,UROKINASE,,,,stroke disorder,,,,, +11808316,4233,,related to,,UROKINASE,,,,empyema,,,,, +9909017,4234,,related to,,UROKINASE,,,,pleural empyema,,,,, +9695495,4235,,related to,,UROKINASE,,,,thrombotic disease,,,,, +7757067,4236,,related to,,UROKINASE,,,,pulmonary embolism,,,,, +20949144,4237,,causes,,UROKINASE,,,,thrombotic disease,,,,, +7392657,4238,,causes,,UROKINASE,,,,pulmonary embolism,,,,, +26135964,4239,,affects,,UROKINASE,,,,pulmonary embolism,,,,, +25781305,4240,,affects,,UROKINASE,,,,thrombotic disease,,,,, +26885635,4241,,disrupts,,UROKINASE,,,,thrombotic disease,,,,, +11607211,4242,,prevents,,UROKINASE,,,,thrombotic disease,,,,, +8505599,4243,,prevents,,UROKINASE,,,,pulmonary embolism,,,,, +26334889,4244,,predisposes,,UROKINASE,,,,pulmonary embolism,,,,, +13797160,4245,,predisposes,,UROKINASE,,,,thrombotic disease,,,,, +13590349,4246,,causes,,Buspirone,,,,depressive disorder,,,,, +7712722,4247,,affects,,Buspirone,,,,depressive disorder,,,,, +7425584,4248,,affects,,Buspirone,,,,physiological sexual disorder,,,,, +19950288,4249,,disrupts,,Buspirone,,,,schizophrenia,,,,, +10992881,4250,,disrupts,,Buspirone,,,,anxiety,,,,, +19904227,4251,,related to,,Iodine,,,,thyroid tumor,,,,, +10048388,4252,,related to,,Iodine,,,,breast neoplasm,,,,, +10651106,4253,,causes,,Iodine,,,,thyroid tumor,,,,, +10745802,4254,,affects,,Iodine,,,,thyroid tumor,,,,, +24773674,4255,,prevents,,Iodine,,,,thyroid tumor,,,,, +27167996,4256,,predisposes,,Iodine,,,,thyroid tumor,,,,, +7362584,4257,,subclass of,,Acetaminophen,,,,Acetaminophen sulfate,,,,, +7362582,4258,,subclass of,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +26133523,4259,,related to,,Acetaminophen,,,,neoplasm,,,,, +25084939,4260,,related to,,Acetaminophen,,,,Acetimidoquinone,,,,, +24055705,4261,,related to,,Acetaminophen,,,,osteoarthritis,,,,, +20371329,4262,,related to,,Acetaminophen,,,,digestive system disorder,,,,, +19637295,4263,,related to,,Acetaminophen,,,,Renal Colic,,,,, +16009572,4264,,related to,,Acetaminophen,,,,rheumatoid arthritis,,,,, +12233599,4265,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +12541409,4266,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +15777318,4267,,coexists with,,Acetaminophen,,,,Acetimidoquinone,,,,, +18513016,4268,,derives from,,Acetaminophen,,,,Acetimidoquinone,,,,, +16596646,4269,,derives from,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +7891577,4270,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, +11100770,4271,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, +8441876,4272,,physically interacts with,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +25685005,4273,,causes,,Acetaminophen,,,,neoplasm,,,,, +24327037,4274,,causes,,Acetaminophen,,,,anxiety,,,,, +23482103,4275,,causes,,Acetaminophen,,,,nervous system disorder,,,,, +21920646,4276,,causes,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, +21160030,4277,,causes,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, +19409287,4278,,causes,,Acetaminophen,,,,myopia,,,,, +17485084,4279,,causes,,Acetaminophen,,,,obesity disorder,,,,, +17093716,4280,,causes,,Acetaminophen,,,,kidney disorder,,,,, +16903597,4281,,causes,,Acetaminophen,,,,hypertensive disorder,,,,, +16867510,4282,,causes,,Acetaminophen,,,,delirium,,,,, +16756158,4283,,causes,,Acetaminophen,,,,osteoarthritis,,,,, +16155885,4284,,causes,,Acetaminophen,,,,Hemorrhage,,,,, +15922778,4285,,causes,,Acetaminophen,,,,Pruritus,,,,, +14972793,4286,,causes,,Acetaminophen,,,,brain injury,,,,, +12302511,4287,,causes,,Acetaminophen,,,,Headache,,,,, +9507087,4288,,causes,,Acetaminophen,,,,Vomiting,,,,, +8697178,4289,,causes,,Acetaminophen,,,,Pain,,,,, +8697177,4290,,causes,,Acetaminophen,,,,Fever,,,,, +7330301,4291,,causes,,Acetaminophen,,,,injury,,,,, +24793249,4292,,affects,,Acetaminophen,,,,hypertensive disorder,,,,, +23912807,4293,,affects,,Acetaminophen,,,,Vomiting,,,,, +23912806,4294,,affects,,Acetaminophen,,,,Nausea,,,,, +23442508,4295,,affects,,Acetaminophen,,,,pharyngitis,,,,, +23226380,4296,,affects,,Acetaminophen,,,,anxiety,,,,, +22849168,4297,,affects,,Acetaminophen,,,,neoplasm,,,,, +22389406,4298,,affects,,Acetaminophen,,,,Low back pain,,,,, +22267005,4299,,affects,,Acetaminophen,,,,Acute Pain,,,,, +21609859,4300,,affects,,Acetaminophen,,,,migraine disorder,,,,, +21375424,4301,,affects,,Acetaminophen,,,,preeclampsia,,,,, +21166764,4302,,affects,,Acetaminophen,,,,Parkinson disease,,,,, +20477729,4303,,affects,,Acetaminophen,,,,Hemorrhage,,,,, +20447454,4304,,affects,,Acetaminophen,,,,rheumatoid arthritis,,,,, +19937801,4305,,affects,,Acetaminophen,,,,Pain,,,,, +19285056,4306,,affects,,Acetaminophen,,,,Renal Colic,,,,, +18899993,4307,,affects,,Acetaminophen,,,,Abdominal pain,,,,, +18709599,4308,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, +18394888,4309,,affects,,Acetaminophen,,,,Headache,,,,, +18298999,4310,,affects,,Acetaminophen,,,,patent ductus arteriosus,,,,, +16707575,4311,,affects,,Acetaminophen,,,,obesity disorder,,,,, +16662805,4312,,affects,,Acetaminophen,,,,Vomiting,,,,, +16662804,4313,,affects,,Acetaminophen,,,,Nausea,,,,, +15922777,4314,,affects,,Acetaminophen,,,,Pruritus,,,,, +15909356,4315,,affects,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, +12673406,4316,,affects,,Acetaminophen,,,,bone fracture,,,,, +12488756,4317,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +11625632,4318,,affects,,Acetaminophen,,,,Chronic pain,,,,, +11439823,4319,,affects,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, +11319146,4320,,affects,,Acetaminophen,,,,neuralgia,,,,, +11289717,4321,,affects,,Acetaminophen,,,,osteoarthritis,,,,, +11227783,4322,,affects,,Acetaminophen,,,,Fever,,,,, +11159989,4323,,affects,,Acetaminophen,,,,Hemorrhage,,,,, +10410536,4324,,affects,,Acetaminophen,,,,injury,,,,, +10195419,4325,,affects,,Acetaminophen,,,,Pain,,,,, +9259287,4326,,affects,,Acetaminophen,,,,Fever,,,,, +8642669,4327,,affects,,Acetaminophen,,,,Hemorrhage,,,,, +8097597,4328,,affects,,Acetaminophen,,,,injury,,,,, +25639149,4329,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +20782169,4330,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, +25481457,4331,,disrupts,,Acetaminophen,,,,patent ductus arteriosus,,,,, +25355292,4332,,disrupts,,Acetaminophen,,,,delirium,,,,, +19614622,4333,,disrupts,,Acetaminophen,,,,Headache,,,,, +16273113,4334,,disrupts,,Acetaminophen,,,,Fever,,,,, +12102031,4335,,disrupts,,Acetaminophen,,,,Pain,,,,, +7794905,4336,,disrupts,,Acetaminophen,,,,influenza,,,,, +7640332,4337,,disrupts,,Acetaminophen,,,,injury,,,,, +26559635,4338,,prevents,,Acetaminophen,,,,malaria,,,,, +22159381,4339,,prevents,,Acetaminophen,,,,Hemorrhage,,,,, +22123298,4340,,prevents,,Acetaminophen,,,,Fever,,,,, +20154151,4341,,prevents,,Acetaminophen,,,,neuralgia,,,,, +20107193,4342,,prevents,,Acetaminophen,,,,delirium,,,,, +19168014,4343,,prevents,,Acetaminophen,,,,obesity disorder,,,,, +19006111,4344,,prevents,,Acetaminophen,,,,patent ductus arteriosus,,,,, +18131378,4345,,prevents,,Acetaminophen,,,,Low back pain,,,,, +18033682,4346,,prevents,,Acetaminophen,,,,Vomiting,,,,, +16975983,4347,,prevents,,Acetaminophen,,,,neoplasm,,,,, +16828191,4348,,prevents,,Acetaminophen,,,,rheumatoid arthritis,,,,, +16784082,4349,,prevents,,Acetaminophen,,,,injury,,,,, +16782348,4350,,prevents,,Acetaminophen,,,,Nausea,,,,, +15909357,4351,,prevents,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, +15525446,4352,,prevents,,Acetaminophen,,,,Acute Pain,,,,, +15467414,4353,,prevents,,Acetaminophen,,,,influenza,,,,, +14660734,4354,,prevents,,Acetaminophen,,,,cardiac rhythm disease,,,,, +14372292,4355,,prevents,,Acetaminophen,,,,Headache,,,,, +13804263,4356,,prevents,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, +8695490,4357,,prevents,,Acetaminophen,,,,Pain,,,,, +25567880,4358,,predisposes,,Acetaminophen,,,,Sepsis,,,,, +24917204,4359,,predisposes,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, +22230555,4360,,predisposes,,Acetaminophen,,,,delirium,,,,, +21723139,4361,,predisposes,,Acetaminophen,,,,Hemorrhage,,,,, +20594449,4362,,predisposes,,Acetaminophen,,,,neoplasm,,,,, +19914508,4363,,predisposes,,Acetaminophen,,,,Pain,,,,, +16209480,4364,,predisposes,,Acetaminophen,,,,kidney disorder,,,,, +13597848,4365,,predisposes,,Acetaminophen,,,,injury,,,,, +13536066,4366,,predisposes,,Acetaminophen,,,,non-small cell lung carcinoma,,,,, +12673403,4367,,predisposes,,Acetaminophen,,,,bone fracture,,,,, +12109634,4368,,predisposes,,Acetaminophen,,,,Parkinson disease,,,,, +11873681,4369,,predisposes,,Acetaminophen,,,,non-Hodgkin lymphoma,,,,, +9834508,4370,,predisposes,,Acetaminophen,,,,hypertensive disorder,,,,, +8862839,4371,,predisposes,,Acetaminophen,,,,streptococcal infection,,,,, +10289439,4372,,related to,,Chlorthalidone,,,,hypertensive disorder,,,,, +10185607,4373,,related to,,Chlorthalidone,,,,coronary artery disorder,,,,, +10185606,4374,,related to,,Chlorthalidone,,,,myocardial infarction,,,,, +7839079,4375,,related to,,Chlorthalidone,,,,essential hypertension,,,,, +21616164,4376,,affects,,Chlorthalidone,,,,myocardial infarction,,,,, +21616163,4377,,affects,,Chlorthalidone,,,,coronary artery disorder,,,,, +16399514,4378,,affects,,Chlorthalidone,,,,essential hypertension,,,,, +16281975,4379,,affects,,Chlorthalidone,,,,hypertensive disorder,,,,, +11587035,4380,,affects,,Chlorthalidone,,,,diabetes mellitus,,,,, +11095498,4381,,prevents,,Chlorthalidone,,,,myocardial infarction,,,,, +11095497,4382,,prevents,,Chlorthalidone,,,,coronary artery disorder,,,,, +8853238,4383,,prevents,,Chlorthalidone,,,,myocardial ischemia,,,,, +8036244,4384,,prevents,,Chlorthalidone,,,,hypertensive disorder,,,,, +11078982,4385,,predisposes,,Chlorthalidone,,,,coronary artery disorder,,,,, +19123757,4386,,causes,,Propacetamol,,,,Pain,,,,, +11402898,4387,,prevents,,Propacetamol,,,,Pain,,,,, +25540651,4388,,affects,,Isopropyl Alcohol,,,,Nausea,,,,, +18311094,4389,,affects,,Isopropyl Alcohol,,,,infectious disease,,,,, +10697335,4390,,affects,,Isopropyl Alcohol,,,,burn,,,,, +9427033,4391,,prevents,,Isopropyl Alcohol,,,,infectious disease,,,,, +21320482,4392,,related to,,Ethanol,,,,substance-related disorder,,,,, +15908919,4393,,related to,,Ethanol,,,,hypertensive disorder,,,,, +14538852,4394,,related to,,Ethanol,,,,atrial fibrillation,,,,, +13852361,4395,,related to,,Ethanol,,,,obesity disorder,,,,, +27116018,4396,,causes,,Ethanol,,,,neutropenia,,,,, +26520376,4397,,causes,,Ethanol,,,,essential hypertension,,,,, +17336935,4398,,causes,,Ethanol,,,,Tremor,,,,, +15073107,4399,,causes,,Ethanol,,,,alcohol-related disorders,,,,, +14779551,4400,,causes,,Ethanol,,,,burn,,,,, +12227250,4401,,causes,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, +11665347,4402,,causes,,Ethanol,,,,erectile dysfunction,,,,, +11096896,4403,,causes,,Ethanol,,,,type 2 diabetes mellitus,,,,, +10962858,4404,,causes,,Ethanol,,,,atrial fibrillation,,,,, +9159992,4405,,causes,,Ethanol,,,,obesity disorder,,,,, +8743651,4406,,causes,,Ethanol,,,,alcohol abuse,,,,, +8636726,4407,,causes,,Ethanol,,,,major depressive disorder,,,,, +8268450,4408,,causes,,Ethanol,,,,atopic eczema,,,,, +7771647,4409,,causes,,Ethanol,,,,hypertensive disorder,,,,, +7460012,4410,,causes,,Ethanol,,,,cirrhosis of liver,,,,, +27580478,4411,,affects,,Ethanol,,,,cirrhosis of liver,,,,, +27514790,4412,,affects,,Ethanol,,,,Thyroid nodule,,,,, +26762447,4413,,affects,,Ethanol,,,,neutropenia,,,,, +23912654,4414,,affects,,Ethanol,,,,atrial fibrillation,,,,, +23763968,4415,,affects,,Ethanol,,,,substance-related disorder,,,,, +19533165,4416,,affects,,Ethanol,,,,hypertensive disorder,,,,, +19155713,4417,,affects,,Ethanol,,,,cannabis dependence,,,,, +16819917,4418,,affects,,Ethanol,,,,Chronic pain,,,,, +15671844,4419,,affects,,Ethanol,,,,obesity disorder,,,,, +14737169,4420,,affects,,Ethanol,,,,Chronic pain,,,,, +14527564,4421,,affects,,Ethanol,,,,benign prostatic hyperplasia,,,,, +13226372,4422,,affects,,Ethanol,,,,atrial fibrillation,,,,, +12698965,4423,,affects,,Ethanol,,,,major depressive disorder,,,,, +12166837,4424,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, +10697334,4425,,affects,,Ethanol,,,,burn,,,,, +9822489,4426,,affects,,Ethanol,,,,Tremor,,,,, +9174558,4427,,affects,,Ethanol,,,,Tremor,,,,, +9116052,4428,,affects,,Ethanol,,,,major depressive disorder,,,,, +8931619,4429,,affects,,Ethanol,,,,hypertensive disorder,,,,, +8730041,4430,,affects,,Ethanol,,,,burn,,,,, +8616967,4431,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, +8569555,4432,,affects,,Ethanol,,,,alcohol abuse,,,,, +8363507,4433,,affects,,Ethanol,,,,obesity disorder,,,,, +7210977,4434,,affects,,Ethanol,,,,alcohol abuse,,,,, +25366419,4435,,disrupts,,Ethanol,,,,ventricular tachycardia,,,,, +24747388,4436,,disrupts,,Ethanol,,,,obesity disorder,,,,, +22793590,4437,,disrupts,,Ethanol,,,,Infection,,,,, +20664067,4438,,disrupts,,Ethanol,,,,Chronic pain,,,,, +19084276,4439,,disrupts,,Ethanol,,,,hypertensive disorder,,,,, +15586620,4440,,disrupts,,Ethanol,,,,Tremor,,,,, +15580442,4441,,disrupts,,Ethanol,,,,atrial fibrillation,,,,, +12535146,4442,,disrupts,,Ethanol,,,,type 2 diabetes mellitus,,,,, +9920913,4443,,disrupts,,Ethanol,,,,constipation disorder,,,,, +27717904,4444,,prevents,,Ethanol,,,,cirrhosis of liver,,,,, +22976273,4445,,prevents,,Ethanol,,,,Infection,,,,, +21338360,4446,,prevents,,Ethanol,,,,atrial fibrillation,,,,, +20664068,4447,,prevents,,Ethanol,,,,Chronic pain,,,,, +14465260,4448,,prevents,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, +13158318,4449,,prevents,,Ethanol,,,,erectile dysfunction,,,,, +12078103,4450,,prevents,,Ethanol,,,,alcohol abuse,,,,, +11890775,4451,,prevents,,Ethanol,,,,type 2 diabetes mellitus,,,,, +11547578,4452,,prevents,,Ethanol,,,,Tremor,,,,, +10032139,4453,,prevents,,Ethanol,,,,obesity disorder,,,,, +8207881,4454,,prevents,,Ethanol,,,,hypertensive disorder,,,,, +26228661,4455,,predisposes,,Ethanol,,,,essential hypertension,,,,, +23006394,4456,,predisposes,,Ethanol,,,,constipation disorder,,,,, +21458894,4457,,predisposes,,Ethanol,,,,burn,,,,, +21015200,4458,,predisposes,,Ethanol,,,,benign prostatic hyperplasia,,,,, +20014749,4459,,predisposes,,Ethanol,,,,neuroblastoma,,,,, +19550164,4460,,predisposes,,Ethanol,,,,endometriosis,,,,, +15239058,4461,,predisposes,,Ethanol,,,,cannabis dependence,,,,, +13742110,4462,,predisposes,,Ethanol,,,,cirrhosis of liver,,,,, +13158317,4463,,predisposes,,Ethanol,,,,erectile dysfunction,,,,, +11801709,4464,,predisposes,,Ethanol,,,,type 2 diabetes mellitus,,,,, +11652545,4465,,predisposes,,Ethanol,,,,obesity disorder,,,,, +11461204,4466,,predisposes,,Ethanol,,,,atrial fibrillation,,,,, +9864711,4467,,predisposes,,Ethanol,,,,major depressive disorder,,,,, +9226083,4468,,predisposes,,Ethanol,,,,alcohol abuse,,,,, +8895200,4469,,predisposes,,Ethanol,,,,hypertensive disorder,,,,, +22402878,4470,,related to,,Sodium Hypochlorite,,,,Infection,,,,, +22402879,4471,,prevents,,Sodium Hypochlorite,,,,Infection,,,,, +22325598,4472,,prevents,,Sodium Hypochlorite,,,,Pain,,,,, +23522159,4473,,related to,,Hydrogen Peroxide,,,,gingivitis,,,,, +10185817,4474,,related to,,Hydrogen Peroxide,,,,acne,,,,, +9091124,4475,,related to,,Hydrogen Peroxide,,,,injury,,,,, +21979927,4476,,causes,,Hydrogen Peroxide,,,,seborrheic keratosis,,,,, +7121153,4477,,causes,,Hydrogen Peroxide,,,,injury,,,,, +18988282,4478,,affects,,Hydrogen Peroxide,,,,severe acute respiratory syndrome,,,,, +15261236,4479,,affects,,Hydrogen Peroxide,,,,gingivitis,,,,, +9489971,4480,,affects,,Hydrogen Peroxide,,,,injury,,,,, +7188934,4481,,affects,,Hydrogen Peroxide,,,,injury,,,,, +20490056,4482,,disrupts,,Hydrogen Peroxide,,,,dental caries,,,,, +17081431,4483,,disrupts,,Hydrogen Peroxide,,,,injury,,,,, +8804977,4484,,disrupts,,Hydrogen Peroxide,,,,gingivitis,,,,, +21124110,4485,,prevents,,Hydrogen Peroxide,,,,acne,,,,, +11091070,4486,,prevents,,Hydrogen Peroxide,,,,gingivitis,,,,, +7482647,4487,,prevents,,Hydrogen Peroxide,,,,injury,,,,, +19925807,4488,,predisposes,,Hydrogen Peroxide,,,,dental caries,,,,, +10852631,4489,,predisposes,,Hydrogen Peroxide,,,,injury,,,,, +23181733,4490,,related to,,Vitamin K1,,,,Hemorrhage,,,,, +20221966,4491,,related to,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, +19764095,4492,,related to,,Vitamin K1,,,,osteoporosis,,,,, +17682094,4493,,related to,,Vitamin K1,,,,atrial fibrillation,,,,, +13777524,4494,,related to,,Vitamin K1,,,,cystic fibrosis,,,,, +11304774,4495,,affects,,Vitamin K1,,,,Hemorrhage,,,,, +24408540,4496,,prevents,,Vitamin K1,,,,Hemorrhage,,,,, +13476259,4497,,prevents,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, +10772424,4498,,predisposes,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, +9319754,4499,,predisposes,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, +24430542,4500,,causes,,Indapamide,,,,type 2 diabetes mellitus,,,,, +24430545,4501,,affects,,Indapamide,,,,type 2 diabetes mellitus,,,,, +10214767,4502,,affects,,Indapamide,,,,hypertensive disorder,,,,, +13327254,4503,,prevents,,Indapamide,,,,hypertensive disorder,,,,, +18173402,4504,,related to,,Perphenazine,,,,schizophrenia,,,,, +11307427,4505,,related to,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, +19924977,4506,,disrupts,,Perphenazine,,,,cocaine dependence,,,,, +19924976,4507,,disrupts,,Perphenazine,,,,schizophrenia,,,,, +15171439,4508,,prevents,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, +27208453,4509,,exacerbates,,Perphenazine,,,,dementia,,,,, +26847530,4510,,affects,,Fluphenazine,,,,psychotic disorder,,,,, +11127872,4511,,prevents,,Fluphenazine,,,,psychotic disorder,,,,, +10396371,4512,,disrupts,,Prochlorperazine,,,,Nausea,,,,, +11808182,4513,,prevents,,Prochlorperazine,,,,Postoperative Nausea and Vomiting,,,,, +10634177,4514,,prevents,,Prochlorperazine,,,,migraine disorder,,,,, +7427448,4515,,prevents,,Prochlorperazine,,,,Nausea,,,,, +11272109,4516,,related to,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, +26291786,4517,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, +26291786,4518,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, +16241796,4519,,physically interacts with,,ELOSULFASE ALFA,,,,Keratan,,,,, +16652816,4520,,causes,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, +13130107,4521,,affects,,ELOSULFASE ALFA,,,,Keratan,,,,, +21593588,4522,,related to,,Pegvaliase,,,,phenylketonuria,,,,, +23111774,4523,,related to,,Labetalol,,,,preeclampsia,,,,, +19865755,4524,,related to,,Labetalol,,,,hypertensive disorder,,,,, +19886747,4525,,causes,,Labetalol,,,,hypertensive disorder,,,,, +7968423,4526,,causes,,Labetalol,,,,hypotensive disorder,,,,, +26371124,4527,,affects,,Labetalol,,,,hypertensive disorder,,,,, +16245918,4528,,affects,,Labetalol,,,,stroke disorder,,,,, +15472186,4529,,affects,,Labetalol,,,,hypertensive disorder,,,,, +11424839,4530,,affects,,Labetalol,,,,hypotensive disorder,,,,, +24194004,4531,,prevents,,Labetalol,,,,preeclampsia,,,,, +16282554,4532,,prevents,,Labetalol,,,,hypertensive disorder,,,,, +16892434,4533,,predisposes,,Labetalol,,,,stroke disorder,,,,, +15232781,4534,,related to,,Carvedilol,,,,hypertensive disorder,,,,, +15407113,4535,,causes,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +14049404,4536,,causes,,Carvedilol,,,,epilepsy,,,,, +19046224,4537,,affects,,Carvedilol,,,,esophageal varices,,,,, +17542363,4538,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +11530189,4539,,affects,,Carvedilol,,,,essential hypertension,,,,, +11200172,4540,,affects,,Carvedilol,,,,atrial fibrillation,,,,, +10614289,4541,,affects,,Carvedilol,,,,Stable angina,,,,, +10614288,4542,,affects,,Carvedilol,,,,hypertensive disorder,,,,, +10402879,4543,,affects,,Carvedilol,,,,hypertensive disorder,,,,, +9269217,4544,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +9116913,4545,,affects,,Carvedilol,,,,cardiovascular disorder,,,,, +7256243,4546,,affects,,Carvedilol,,,,portal hypertension,,,,, +24587957,4547,,disrupts,,Carvedilol,,,,portal hypertension,,,,, +21108262,4548,,disrupts,,Carvedilol,,,,myocardial infarction,,,,, +13210472,4549,,disrupts,,Carvedilol,,,,atrial fibrillation,,,,, +23631897,4550,,prevents,,Carvedilol,,,,neoplasm,,,,, +23413400,4551,,prevents,,Carvedilol,,,,myocardial infarction,,,,, +20796578,4552,,prevents,,Carvedilol,,,,hypoglycemia,,,,, +17416516,4553,,prevents,,Carvedilol,,,,portal hypertension,,,,, +15996194,4554,,prevents,,Carvedilol,,,,hypertensive disorder,,,,, +15794060,4555,,prevents,,Carvedilol,,,,Abnormal left ventricular function,,,,, +15707001,4556,,prevents,,Carvedilol,,,,kidney disorder,,,,, +12564717,4557,,prevents,,Carvedilol,,,,atrial fibrillation,,,,, +8686828,4558,,prevents,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +23747042,4559,,predisposes,,Carvedilol,,,,type 2 diabetes mellitus,,,,, +22663350,4560,,predisposes,,Carvedilol,,,,atrial fibrillation,,,,, +21640789,4561,,predisposes,,Carvedilol,,,,hypoglycemia,,,,, +21331523,4562,,predisposes,,Carvedilol,,,,myocardial infarction,,,,, +20291576,4563,,related to,,Raloxifene,,,,schizophrenia,,,,, +13558027,4564,,related to,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +27583128,4565,,causes,,Raloxifene,,,,breast neoplasm,,,,, +20242808,4566,,affects,,Raloxifene,,,,psychotic disorder,,,,, +16098538,4567,,affects,,Raloxifene,,,,schizophrenia,,,,, +15267794,4568,,affects,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, +11233936,4569,,affects,,Raloxifene,,,,breast neoplasm,,,,, +10869334,4570,,affects,,Raloxifene,,,,osteoporosis,,,,, +9569313,4571,,affects,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +15267792,4572,,disrupts,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, +13369623,4573,,disrupts,,Raloxifene,,,,osteoporosis,,,,, +7874352,4574,,disrupts,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +16984197,4575,,prevents,,Raloxifene,,,,Alzheimer disease,,,,, +12036378,4576,,prevents,,Raloxifene,,,,breast neoplasm,,,,, +7813032,4577,,prevents,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +7578651,4578,,prevents,,Raloxifene,,,,osteoporosis,,,,, +7570810,4579,,prevents,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, +11746046,4580,,predisposes,,Raloxifene,,,,Alzheimer disease,,,,, +11350173,4581,,predisposes,,Raloxifene,,,,osteoporosis,,,,, +23481448,4582,,prevents,,Bazedoxifene acetate,,,,osteoporosis,,,,, +19905553,4583,,disrupts,,Ospemifene,,,,psychologic dyspareunia,,,,, +15516940,4584,,affects,,Sufentanil,,,,Pain,,,,, +20743116,4585,,prevents,,Sufentanil,,,,delirium,,,,, +8151024,4586,,prevents,,Sufentanil,,,,Pain,,,,, +12819365,4587,,related to,,Streptomycin,,,,Buruli ulcer disease,,,,, +11425591,4588,,related to,,Streptomycin,,,,osteomyelitis,,,,, +10417352,4589,,related to,,Streptomycin,,,,plague,,,,, +10748245,4590,,causes,,Streptomycin,,,,plague,,,,, +26655494,4591,,prevents,,Streptomycin,,,,mycobacterium avium complex disease,,,,, +14226518,4592,,related to,,Paromomycin,,,,cutaneous leishmaniasis,,,,, +12550860,4593,,related to,,Paromomycin,,,,visceral leishmaniasis,,,,, +24692385,4594,,affects,,Paromomycin,,,,leishmaniasis,,,,, +23700620,4595,,affects,,Paromomycin,,,,visceral leishmaniasis,,,,, +22567030,4596,,affects,,Paromomycin,,,,cutaneous leishmaniasis,,,,, +27729096,4597,,related to,,Kanamycin,,,,bacterial infectious disease,,,,, +10553348,4598,,related to,,Kanamycin,,,,tuberculosis,,,,, +10567002,4599,,affects,,Kanamycin,,,,tuberculosis,,,,, +25418796,4600,,related to,,Vancomycin,,,,ulcerative colitis,,,,, +24528866,4601,,related to,,Vancomycin,,,,bacterial infectious disease,,,,, +23989025,4602,,related to,,Vancomycin,,,,Inflammation,,,,, +22667296,4603,,related to,,Vancomycin,,,,arthropathy,,,,, +21740759,4604,,related to,,Vancomycin,,,,Infection,,,,, +20543239,4605,,related to,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, +20099844,4606,,related to,,Vancomycin,,,,cystic fibrosis,,,,, +18717834,4607,,related to,,Vancomycin,,,,eye infectious disorder,,,,, +18563763,4608,,related to,,Vancomycin,,,,staphylococcal pneumonia,,,,, +17578296,4609,,related to,,Vancomycin,,,,Peptidoglycan,,,,, +17578296,4610,,related to,,Vancomycin,,,,Peptidoglycan,,,,, +15843803,4611,,related to,,Vancomycin,,,,Diabetic Foot,,,,, +15502624,4612,,related to,,Vancomycin,,,,abscess,,,,, +15448370,4613,,related to,,Vancomycin,,,,obesity disorder,,,,, +15389679,4614,,related to,,Vancomycin,,,,osteomyelitis,,,,, +15008716,4615,,related to,,Vancomycin,,,,peritonitis,,,,, +14607992,4616,,related to,,Vancomycin,,,,pneumonia,,,,, +14564943,4617,,related to,,Vancomycin,,,,gram-positive bacterial infections,,,,, +11348824,4618,,related to,,Vancomycin,,,,kidney failure,,,,, +11195361,4619,,related to,,Vancomycin,,,,Neonatal sepsis,,,,, +10946982,4620,,related to,,Vancomycin,,,,respiratory tract infectious disorder,,,,, +10225522,4621,,related to,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, +9057886,4622,,related to,,Vancomycin,,,,nosocomial infection,,,,, +9057885,4623,,related to,,Vancomycin,,,,staphylococcal infection,,,,, +8859000,4624,,related to,,Vancomycin,,,,endocarditis,,,,, +8170422,4625,,related to,,Vancomycin,,,,Sepsis,,,,, +23445509,4626,,related to,,Vancomycin,,,,peritonitis,,,,, +22719539,4627,,related to,,Vancomycin,,,,Infection,,,,, +11098147,4628,,related to,,Vancomycin,,,,Inflammation,,,,, +14094746,4629,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, +14094746,4630,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, +7840667,4631,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, +7710804,4632,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, +26896148,4633,,causes,,Vancomycin,,,,endocarditis,,,,, +26320414,4634,,causes,,Vancomycin,,,,enterocolitis,,,,, +22849619,4635,,causes,,Vancomycin,,,,Infection,,,,, +22231760,4636,,causes,,Vancomycin,,,,Inflammation,,,,, +21632936,4637,,causes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, +18945219,4638,,causes,,Vancomycin,,,,peritonitis,,,,, +15481792,4639,,causes,,Vancomycin,,,,skin disorder,,,,, +12001625,4640,,causes,,Vancomycin,,,,kidney failure,,,,, +9570250,4641,,causes,,Vancomycin,,,,nosocomial infection,,,,, +23893373,4642,,affects,,Vancomycin,,,,Infection,,,,, +21581118,4643,,affects,,Vancomycin,,,,Infection,,,,, +21291384,4644,,affects,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, +20283933,4645,,affects,,Vancomycin,,,,enterocolitis,,,,, +19879029,4646,,affects,,Vancomycin,,,,cystic fibrosis,,,,, +16899271,4647,,affects,,Vancomycin,,,,Sepsis,,,,, +15270589,4648,,affects,,Vancomycin,,,,peritonitis,,,,, +13735180,4649,,affects,,Vancomycin,,,,pneumonia,,,,, +12348278,4650,,affects,,Vancomycin,,,,Sepsis,,,,, +12348277,4651,,affects,,Vancomycin,,,,osteomyelitis,,,,, +12348276,4652,,affects,,Vancomycin,,,,endocarditis,,,,, +7991855,4653,,affects,,Vancomycin,,,,Peptidoglycan,,,,, +7527991,4654,,affects,,Vancomycin,,,,pneumonia,,,,, +17707788,4655,,affects,,Vancomycin,,,,Peptidoglycan,,,,, +22719533,4656,,disrupts,,Vancomycin,,,,Infection,,,,, +21036263,4657,,disrupts,,Vancomycin,,,,osteomyelitis,,,,, +19924841,4658,,disrupts,,Vancomycin,,,,Inflammation,,,,, +14538194,4659,,disrupts,,Vancomycin,,,,enterocolitis,,,,, +21888394,4660,,prevents,,Vancomycin,,,,bacterial infectious disease,,,,, +21518539,4661,,prevents,,Vancomycin,,,,Infection,,,,, +21292683,4662,,prevents,,Vancomycin,,,,osteomyelitis,,,,, +20759704,4663,,prevents,,Vancomycin,,,,kidney failure,,,,, +20759520,4664,,prevents,,Vancomycin,,,,arthropathy,,,,, +16424860,4665,,prevents,,Vancomycin,,,,pneumonia,,,,, +11136130,4666,,prevents,,Vancomycin,,,,nosocomial infection,,,,, +8520533,4667,,prevents,,Vancomycin,,,,peritonitis,,,,, +8203212,4668,,prevents,,Vancomycin,,,,endocarditis,,,,, +8170423,4669,,prevents,,Vancomycin,,,,Neonatal sepsis,,,,, +8170420,4670,,prevents,,Vancomycin,,,,Sepsis,,,,, +7111089,4671,,prevents,,Vancomycin,,,,Inflammation,,,,, +25178384,4672,,exacerbates,,Vancomycin,,,,Inflammation,,,,, +21622859,4673,,exacerbates,,Vancomycin,,,,pneumonia,,,,, +21314122,4674,,predisposes,,Vancomycin,,,,Sepsis,,,,, +19879549,4675,,predisposes,,Vancomycin,,,,kidney failure,,,,, +18555479,4676,,predisposes,,Vancomycin,,,,pneumonia,,,,, +18327103,4677,,predisposes,,Vancomycin,,,,nosocomial infection,,,,, +12689487,4678,,predisposes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, +12018679,4679,,related to,,LENOGRASTIM,,,,plasma cell myeloma,,,,, +24207855,4680,,related to,,SARGRAMOSTIM,,,,pulmonary alveolar proteinosis,,,,, +23712911,4681,,related to,,SARGRAMOSTIM,,,,Sepsis,,,,, +23712910,4682,,related to,,SARGRAMOSTIM,,,,adult acute respiratory distress syndrome,,,,, +23177848,4683,,related to,,SARGRAMOSTIM,,,,Alzheimer disease,,,,, +16827749,4684,,related to,,SARGRAMOSTIM,,,,prostate cancer,,,,, +11846978,4685,,related to,,SARGRAMOSTIM,,,,Crohn disease,,,,, +7671811,4686,,related to,,SARGRAMOSTIM,,,,HIV infectious disease,,,,, +7896656,4687,,prevents,,SARGRAMOSTIM,,,,neutropenia,,,,, +27611311,4688,,related to,,Filgrastim,,,,sarcoma,,,,, +26602673,4689,,related to,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, +26505391,4690,,related to,,Filgrastim,,,,Hodgkins lymphoma,,,,, +23038064,4691,,related to,,Filgrastim,,,,Infection,,,,, +22749433,4692,,related to,,Filgrastim,,,,neoplasm,,,,, +19713781,4693,,related to,,Filgrastim,,,,lymphoma,,,,, +18903615,4694,,related to,,Filgrastim,,,,HIV infectious disease,,,,, +17402873,4695,,related to,,Filgrastim,,,,acute myeloid leukemia,,,,, +16080456,4696,,related to,,Filgrastim,,,,plasma cell myeloma,,,,, +14467347,4697,,related to,,Filgrastim,,,,myocardial infarction,,,,, +13860825,4698,,related to,,Filgrastim,,,,small cell lung carcinoma,,,,, +10253688,4699,,related to,,Filgrastim,,,,ovarian cancer,,,,, +9334871,4700,,related to,,Filgrastim,,,,non-small cell lung carcinoma,,,,, +7868897,4701,,related to,,Filgrastim,,,,neutropenia,,,,, +7775323,4702,,related to,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, +13176527,4703,,has part,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, +27488127,4704,,causes,,Filgrastim,,,,acute myeloid leukemia,,,,, +26596932,4705,,causes,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, +19245347,4706,,causes,,Filgrastim,,,,myeloproliferative neoplasm,,,,, +8419399,4707,,causes,,Filgrastim,,,,neutropenia,,,,, +26496059,4708,,affects,,Filgrastim,,,,neutropenia,,,,, +15351355,4709,,affects,,Filgrastim,,,,Fever,,,,, +7868413,4710,,affects,,Filgrastim,,,,neutropenia,,,,, +9501874,4711,,disrupts,,Filgrastim,,,,neutropenia,,,,, +14309803,4712,,prevents,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, +7265196,4713,,prevents,,Filgrastim,,,,neutropenia,,,,, +16134815,4714,,predisposes,,Filgrastim,,,,hematopoietic and lymphoid system neoplasm,,,,, +14495646,4715,,predisposes,,Filgrastim,,,,neutropenia,,,,, +12306052,4716,,affects,,Tibolone,,,,physiological sexual disorder,,,,, +7873396,4717,,prevents,,Tibolone,,,,osteoporosis,,,,, +17565484,4718,,affects,,Cosyntropin,,,,West syndrome,,,,, +11757081,4719,,disrupts,,Cosyntropin,,,,hypertensive disorder,,,,, +19585114,4720,,related to,,Corticotropin,,,,chronic progressive multiple sclerosis,,,,, +15839924,4721,,related to,,Corticotropin,,,,membranous glomerulonephritis,,,,, +10947313,4722,,related to,,Corticotropin,,,,polycystic ovary syndrome,,,,, +10518316,4723,,related to,,Corticotropin,,,,dermatomyositis,,,,, +10489579,4724,,related to,,Corticotropin,,,,epilepsy,,,,, +10438408,4725,,related to,,Corticotropin,,,,nephrotic syndrome,,,,, +10431205,4726,,related to,,Corticotropin,,,,sarcoidosis,,,,, +10427009,4727,,related to,,Corticotropin,,,,optic neuritis,,,,, +9718321,4728,,related to,,Corticotropin,,,,rheumatoid arthritis,,,,, +8496620,4729,,related to,,Corticotropin,,,,multiple sclerosis,,,,, +7394246,4730,,related to,,Corticotropin,,,,West syndrome,,,,, +22849896,4731,,causes,,Corticotropin,,,,West syndrome,,,,, +12436107,4732,,causes,,Corticotropin,,,,epilepsy,,,,, +11010111,4733,,causes,,Corticotropin,,,,rheumatoid arthritis,,,,, +17565428,4734,,affects,,Corticotropin,,,,West syndrome,,,,, +15783986,4735,,affects,,Corticotropin,,,,multiple sclerosis,,,,, +15695412,4736,,affects,,Corticotropin,,,,polycystic ovary syndrome,,,,, +11427275,4737,,affects,,Corticotropin,,,,dermatomyositis,,,,, +10737513,4738,,affects,,Corticotropin,,,,sarcoidosis,,,,, +10422766,4739,,affects,,Corticotropin,,,,rheumatoid arthritis,,,,, +9312832,4740,,affects,,Corticotropin,,,,epilepsy,,,,, +15159690,4741,,disrupts,,Corticotropin,,,,epilepsy,,,,, +27033387,4742,,prevents,,Corticotropin,,,,West syndrome,,,,, +10517176,4743,,prevents,,Corticotropin,,,,epilepsy,,,,, +23224982,4744,,predisposes,,Corticotropin,,,,epilepsy,,,,, +15800284,4745,,related to,,Dabigatran etexilate,,,,atrial fibrillation,,,,, +16972150,4746,,affects,,Dabigatran etexilate,,,,stroke disorder,,,,, +21262475,4747,,prevents,,Dabigatran etexilate,,,,thrombophilia due to thrombin defect,,,,, +19084221,4748,,prevents,,Dabigatran etexilate,,,,thrombotic disease,,,,, +14524874,4749,,prevents,,Dabigatran etexilate,,,,stroke disorder,,,,, +11599698,4750,,prevents,,Dabigatran etexilate,,,,Thromboembolism,,,,, +15929248,4751,,predisposes,,Dabigatran etexilate,,,,stroke disorder,,,,, +13343476,4752,,predisposes,,Dabigatran etexilate,,,,Thromboembolism,,,,, +10867084,4753,,related to,,Ximelagatran,,,,atrial fibrillation,,,,, +12162541,4754,,prevents,,Ximelagatran,,,,thrombotic disease,,,,, +9396435,4755,,prevents,,Ximelagatran,,,,Thromboembolism,,,,, +13148663,4756,,predisposes,,Ximelagatran,,,,Thromboembolism,,,,, +24220155,4757,,related to,,Bivalirudin,,,,Hemorrhage,,,,, +23845334,4758,,related to,,Bivalirudin,,,,thrombocytopenia,,,,, +21128552,4759,,related to,,Bivalirudin,,,,heart disorder,,,,, +16166302,4760,,related to,,Bivalirudin,,,,coronary artery disorder,,,,, +9469606,4761,,related to,,Bivalirudin,,,,myocardial infarction,,,,, +9060136,4762,,related to,,Bivalirudin,,,,acute coronary syndrome,,,,, +21743704,4763,,related to,,Bivalirudin,,,,Hemorrhage,,,,, +18003165,4764,,related to,,Bivalirudin,,,,thrombotic disease,,,,, +15575490,4765,,causes,,Bivalirudin,,,,myocardial infarction,,,,, +10298579,4766,,causes,,Bivalirudin,,,,Hemorrhage,,,,, +19056194,4767,,affects,,Bivalirudin,,,,thrombotic disease,,,,, +15575489,4768,,affects,,Bivalirudin,,,,thrombotic disease,,,,, +14748514,4769,,affects,,Bivalirudin,,,,myocardial infarction,,,,, +14318099,4770,,affects,,Bivalirudin,,,,Hemorrhage,,,,, +9597163,4771,,affects,,Bivalirudin,,,,Hemorrhage,,,,, +19316921,4772,,disrupts,,Bivalirudin,,,,myocardial infarction,,,,, +19056195,4773,,disrupts,,Bivalirudin,,,,thrombotic disease,,,,, +13525067,4774,,disrupts,,Bivalirudin,,,,acute coronary syndrome,,,,, +13434992,4775,,disrupts,,Bivalirudin,,,,Hemorrhage,,,,, +21793150,4776,,prevents,,Bivalirudin,,,,Hemorrhage,,,,, +20637086,4777,,prevents,,Bivalirudin,,,,syndromic disease,,,,, +17823880,4778,,prevents,,Bivalirudin,,,,myocardial infarction,,,,, +10215156,4779,,prevents,,Bivalirudin,,,,thrombotic disease,,,,, +22425248,4780,,predisposes,,Bivalirudin,,,,Hemorrhage,,,,, +16276306,4781,,predisposes,,Bivalirudin,,,,thrombotic disease,,,,, +14172527,4782,,predisposes,,Bivalirudin,,,,myocardial infarction,,,,, +17086386,4783,,disrupts,,Melagatran,,,,thrombotic disease,,,,, +9182682,4784,,related to,,Lepirudin,,,,thrombotic disease,,,,, +27183131,4785,,affects,,Lepirudin,,,,thrombotic disease,,,,, +26612130,4786,,disrupts,,Lepirudin,,,,thrombotic disease,,,,, +9038512,4787,,prevents,,Lepirudin,,,,thrombotic disease,,,,, +24074121,4788,,affects,,Ripasudil,,,,Fuchs' endothelial dystrophy,,,,, +23144840,4789,,prevents,,Netarsudil,,,,corneal edema,,,,, +21457868,4790,,prevents,,Netarsudil,,,,open-angle glaucoma,,,,, +25249408,4791,,related to,,Calcitriol,,,,Hypocalcemia,,,,, +24424216,4792,,related to,,Calcitriol,,,,Crohn disease,,,,, +23057137,4793,,related to,,Calcitriol,,,,acute kidney failure,,,,, +21048179,4794,,related to,,Calcitriol,,,,breast neoplasm,,,,, +18873537,4795,,related to,,Calcitriol,,,,diabetic kidney disease,,,,, +17759117,4796,,related to,,Calcitriol,,,,Sepsis,,,,, +17014883,4797,,related to,,Calcitriol,,,,hypoparathyroidism,,,,, +16783681,4798,,related to,,Calcitriol,,,,non-small cell lung carcinoma,,,,, +16670490,4799,,related to,,Calcitriol,,,,postmenopausal osteoporosis,,,,, +16084679,4800,,related to,,Calcitriol,,,,hypertensive disorder,,,,, +15183062,4801,,related to,,Calcitriol,,,,type 1 diabetes mellitus,,,,, +13574949,4802,,related to,,Calcitriol,,,,neoplasm,,,,, +13228040,4803,,related to,,Calcitriol,,,,castration-resistant prostate carcinoma,,,,, +11632117,4804,,related to,,Calcitriol,,,,prostate cancer,,,,, +11549262,4805,,related to,,Calcitriol,,,,renal osteodystrophy,,,,, +11138207,4806,,related to,,Calcitriol,,,,skin basal cell carcinoma,,,,, +9056874,4807,,related to,,Calcitriol,,,,psoriasis,,,,, +8335532,4808,,related to,,Calcitriol,,,,chronic kidney disease,,,,, +7638906,4809,,related to,,Calcitriol,,,,myelodysplastic syndrome,,,,, +7210521,4810,,related to,,Calcitriol,,,,osteoporosis,,,,, +23300761,4811,,causes,,Calcitriol,,,,hypoparathyroidism,,,,, +22190855,4812,,causes,,Calcitriol,,,,Hypocalcemia,,,,, +13672029,4813,,causes,,Calcitriol,,,,renal osteodystrophy,,,,, +8610431,4814,,causes,,Calcitriol,,,,neoplasm,,,,, +26699785,4815,,affects,,Calcitriol,,,,myelodysplastic syndrome,,,,, +26649101,4816,,affects,,Calcitriol,,,,psoriasis,,,,, +20118335,4817,,affects,,Calcitriol,,,,chronic kidney disease,,,,, +18144364,4818,,affects,,Calcitriol,,,,diabetic kidney disease,,,,, +17907580,4819,,affects,,Calcitriol,,,,breast neoplasm,,,,, +15840384,4820,,affects,,Calcitriol,,,,skin basal cell carcinoma,,,,, +15206874,4821,,affects,,Calcitriol,,,,neoplasm,,,,, +15145405,4822,,affects,,Calcitriol,,,,neoplasm,,,,, +10932246,4823,,affects,,Calcitriol,,,,chronic kidney disease,,,,, +9912093,4824,,affects,,Calcitriol,,,,prostate cancer,,,,, +9912091,4825,,affects,,Calcitriol,,,,prostate cancer,,,,, +26695789,4826,,produces,,Calcitriol,,,,renal osteodystrophy,,,,, +14288417,4827,,produces,,Calcitriol,,,,Crohn disease,,,,, +19013737,4828,,disrupts,,Calcitriol,,,,chronic kidney disease,,,,, +17492128,4829,,disrupts,,Calcitriol,,,,prostate cancer,,,,, +15711853,4830,,disrupts,,Calcitriol,,,,neoplasm,,,,, +23005720,4831,,prevents,,Calcitriol,,,,neoplasm,,,,, +22688863,4832,,prevents,,Calcitriol,,,,Hypocalcemia,,,,, +18398383,4833,,prevents,,Calcitriol,,,,diabetic kidney disease,,,,, +17492127,4834,,prevents,,Calcitriol,,,,prostate cancer,,,,, +8346486,4835,,prevents,,Calcitriol,,,,osteoporosis,,,,, +8053720,4836,,prevents,,Calcitriol,,,,postmenopausal osteoporosis,,,,, +24886178,4837,,exacerbates,,Calcitriol,,,,Sepsis,,,,, +18653087,4838,,exacerbates,,Calcitriol,,,,hypertensive disorder,,,,, +21373396,4839,,predisposes,,Calcitriol,,,,chronic kidney disease,,,,, +17377804,4840,,predisposes,,Calcitriol,,,,hypertensive disorder,,,,, +16828204,4841,,predisposes,,Calcitriol,,,,osteoporosis,,,,, +9760670,4842,,predisposes,,Calcitriol,,,,prostate cancer,,,,, +26462827,4843,,related to,,Alfacalcidol,,,,kidney failure,,,,, +9037270,4844,,related to,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, +7210524,4845,,related to,,Alfacalcidol,,,,osteoporosis,,,,, +22711685,4846,,causes,,Alfacalcidol,,,,osteoporosis,,,,, +26635675,4847,,affects,,Alfacalcidol,,,,kidney failure,,,,, +21927698,4848,,affects,,Alfacalcidol,,,,myopathy,,,,, +11900508,4849,,affects,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, +8505855,4850,,affects,,Alfacalcidol,,,,osteoporosis,,,,, +20641062,4851,,disrupts,,Alfacalcidol,,,,osteoporosis,,,,, +21927699,4852,,prevents,,Alfacalcidol,,,,myopathy,,,,, +7684744,4853,,prevents,,Alfacalcidol,,,,osteoporosis,,,,, +7684734,4854,,prevents,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, +24020567,4855,,related to,,Cholecalciferol,,,,male infertility,,,,, +23185349,4856,,related to,,Cholecalciferol,,,,ulcerative colitis,,,,, +22584995,4857,,related to,,Cholecalciferol,,,,acute myeloid leukemia,,,,, +21514930,4858,,related to,,Cholecalciferol,,,,Infection,,,,, +21254434,4859,,related to,,Cholecalciferol,,,,depressive disorder,,,,, +20389616,4860,,related to,,Cholecalciferol,,,,anemia,,,,, +20190699,4861,,related to,,Cholecalciferol,,,,autism spectrum disorder,,,,, +19639056,4862,,related to,,Cholecalciferol,,,,pulmonary tuberculosis,,,,, +18980881,4863,,related to,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, +18889413,4864,,related to,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, +18830431,4865,,related to,,Cholecalciferol,,,,prostate cancer,,,,, +18776998,4866,,related to,,Cholecalciferol,,,,epilepsy,,,,, +18009382,4867,,related to,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, +17581366,4868,,related to,,Cholecalciferol,,,,vitamin D deficiency,,,,, +17374616,4869,,related to,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, +17169513,4870,,related to,,Cholecalciferol,,,,Parkinson disease,,,,, +17054911,4871,,related to,,Cholecalciferol,,,,tuberculosis,,,,, +16909919,4872,,related to,,Cholecalciferol,,,,inflammatory bowel disease,,,,, +16219443,4873,,related to,,Cholecalciferol,,,,"dermatitis, atopic",,,,, +16115730,4874,,related to,,Cholecalciferol,,,,cardiovascular disorder,,,,, +15133291,4875,,related to,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +14512631,4876,,related to,,Cholecalciferol,,,,hyperparathyroidism,,,,, +13680137,4877,,related to,,Cholecalciferol,,,,multiple sclerosis,,,,, +13562951,4878,,related to,,Cholecalciferol,,,,metabolic syndrome X,,,,, +13562949,4879,,related to,,Cholecalciferol,,,,obesity disorder,,,,, +13035326,4880,,related to,,Cholecalciferol,,,,bone fracture,,,,, +11935565,4881,,related to,,Cholecalciferol,,,,osteoporosis,,,,, +11152529,4882,,related to,,Cholecalciferol,,,,diabetes mellitus,,,,, +10386853,4883,,related to,,Cholecalciferol,,,,Crohn disease,,,,, +9703967,4884,,related to,,Cholecalciferol,,,,melanoma,,,,, +9414232,4885,,related to,,Cholecalciferol,,,,psoriasis,,,,, +8798994,4886,,related to,,Cholecalciferol,,,,hip fracture,,,,, +20878953,4887,,causes,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, +20469671,4888,,causes,,Cholecalciferol,,,,tuberculosis,,,,, +20417553,4889,,causes,,Cholecalciferol,,,,psoriasis,,,,, +19411734,4890,,causes,,Cholecalciferol,,,,"dermatitis, atopic",,,,, +17854537,4891,,causes,,Cholecalciferol,,,,neoplasm,,,,, +15944158,4892,,causes,,Cholecalciferol,,,,vitamin D deficiency,,,,, +13998286,4893,,causes,,Cholecalciferol,,,,depressive disorder,,,,, +27560876,4894,,affects,,Cholecalciferol,,,,prostate cancer,,,,, +22640117,4895,,affects,,Cholecalciferol,,,,severe acute respiratory syndrome,,,,, +21843529,4896,,affects,,Cholecalciferol,,,,Pregnancy,,,,, +21703950,4897,,affects,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +20945952,4898,,affects,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, +20733345,4899,,affects,,Cholecalciferol,,,,epilepsy,,,,, +20612106,4900,,affects,,Cholecalciferol,,,,Cognitive impairment,,,,, +19925618,4901,,affects,,Cholecalciferol,,,,asthma,,,,, +19815601,4902,,affects,,Cholecalciferol,,,,ulcerative colitis,,,,, +19556148,4903,,affects,,Cholecalciferol,,,,neoplasm,,,,, +19132727,4904,,affects,,Cholecalciferol,,,,obesity disorder,,,,, +18122364,4905,,affects,,Cholecalciferol,,,,metabolic syndrome X,,,,, +18122363,4906,,affects,,Cholecalciferol,,,,cardiovascular disorder,,,,, +17715748,4907,,affects,,Cholecalciferol,,,,hip fracture,,,,, +17674517,4908,,affects,,Cholecalciferol,,,,Pregnancy,,,,, +17585577,4909,,affects,,Cholecalciferol,,,,depressive disorder,,,,, +17451551,4910,,affects,,Cholecalciferol,,,,neoplasm,,,,, +16299943,4911,,affects,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, +16007821,4912,,affects,,Cholecalciferol,,,,psoriasis,,,,, +15977971,4913,,affects,,Cholecalciferol,,,,melanoma,,,,, +15944152,4914,,affects,,Cholecalciferol,,,,osteoporosis,,,,, +15393278,4915,,affects,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, +15170889,4916,,affects,,Cholecalciferol,,,,multiple sclerosis,,,,, +13518388,4917,,affects,,Cholecalciferol,,,,bone fracture,,,,, +21045274,4918,,produces,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +17840044,4919,,produces,,Cholecalciferol,,,,inflammatory bowel disease,,,,, +20733344,4920,,disrupts,,Cholecalciferol,,,,epilepsy,,,,, +19044664,4921,,disrupts,,Cholecalciferol,,,,AIDS,,,,, +15558469,4922,,disrupts,,Cholecalciferol,,,,HIV infectious disease,,,,, +14834931,4923,,disrupts,,Cholecalciferol,,,,neoplasm,,,,, +14617748,4924,,disrupts,,Cholecalciferol,,,,multiple sclerosis,,,,, +14491908,4925,,disrupts,,Cholecalciferol,,,,vitamin D deficiency,,,,, +11194374,4926,,disrupts,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +25419746,4927,,prevents,,Cholecalciferol,,,,Infection,,,,, +23552226,4928,,prevents,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, +23324302,4929,,prevents,,Cholecalciferol,,,,ulcerative colitis,,,,, +22418643,4930,,prevents,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, +22340834,4931,,prevents,,Cholecalciferol,,,,depressive disorder,,,,, +20959064,4932,,prevents,,Cholecalciferol,,,,postmenopausal osteoporosis,,,,, +20699168,4933,,prevents,,Cholecalciferol,,,,cardiovascular disorder,,,,, +19389521,4934,,prevents,,Cholecalciferol,,,,epilepsy,,,,, +18282049,4935,,prevents,,Cholecalciferol,,,,inherited lipid metabolism disorder,,,,, +17951280,4936,,prevents,,Cholecalciferol,,,,anemia,,,,, +17701830,4937,,prevents,,Cholecalciferol,,,,influenza,,,,, +15773595,4938,,prevents,,Cholecalciferol,,,,neoplasm,,,,, +15663430,4939,,prevents,,Cholecalciferol,,,,diabetes mellitus,,,,, +12943427,4940,,prevents,,Cholecalciferol,,,,vitamin D deficiency,,,,, +11194373,4941,,prevents,,Cholecalciferol,,,,osteoporosis,,,,, +11017561,4942,,prevents,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +10503621,4943,,prevents,,Cholecalciferol,,,,bone fracture,,,,, +9458588,4944,,prevents,,Cholecalciferol,,,,hip fracture,,,,, +21072124,4945,,predisposes,,Cholecalciferol,,,,metabolic syndrome X,,,,, +18104348,4946,,predisposes,,Cholecalciferol,,,,colorectal neoplasm,,,,, +17901013,4947,,predisposes,,Cholecalciferol,,,,bone fracture,,,,, +17714481,4948,,predisposes,,Cholecalciferol,,,,asthma,,,,, +17184810,4949,,predisposes,,Cholecalciferol,,,,multiple sclerosis,,,,, +15110409,4950,,predisposes,,Cholecalciferol,,,,vitamin D deficiency,,,,, +13562954,4951,,predisposes,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, +9524358,4952,,predisposes,,Cholecalciferol,,,,hip fracture,,,,, +9314384,4953,,predisposes,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +27330803,4954,,related to,,Ergocalciferol,,,,Familial hypophosphatemia,,,,, +26089502,4955,,related to,,Ergocalciferol,,,,osteogenesis imperfecta,,,,, +22199149,4956,,related to,,Ergocalciferol,,,,Hypocalcemia,,,,, +22194600,4957,,related to,,Ergocalciferol,,,,severe acute respiratory syndrome,,,,, +21840711,4958,,related to,,Ergocalciferol,,,,castration-resistant prostate carcinoma,,,,, +21543726,4959,,related to,,Ergocalciferol,,,,sarcopenia,,,,, +21516783,4960,,related to,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, +21478252,4961,,related to,,Ergocalciferol,,,,bone fracture,,,,, +21128214,4962,,related to,,Ergocalciferol,,,,bone Paget disease,,,,, +20256197,4963,,related to,,Ergocalciferol,,,,restless legs syndrome,,,,, +19853448,4964,,related to,,Ergocalciferol,,,,neuralgia,,,,, +19595978,4965,,related to,,Ergocalciferol,,,,hepatitis C virus infection,,,,, +19221334,4966,,related to,,Ergocalciferol,,,,spinal cord injury,,,,, +18303138,4967,,related to,,Ergocalciferol,,,,optic neuritis,,,,, +17457750,4968,,related to,,Ergocalciferol,,,,migraine disorder,,,,, +17248671,4969,,related to,,Ergocalciferol,,,,diffuse alopecia areata,,,,, +16231683,4970,,related to,,Ergocalciferol,,,,chronic hepatitis C virus infection,,,,, +16050991,4971,,related to,,Ergocalciferol,,,,lung neoplasm,,,,, +15954794,4972,,related to,,Ergocalciferol,,,,femoral neck fracture,,,,, +15739454,4973,,related to,,Ergocalciferol,,,,diabetic neuropathy,,,,, +15603622,4974,,related to,,Ergocalciferol,,,,HIV infectious disease,,,,, +15306422,4975,,related to,,Ergocalciferol,,,,blood coagulation disease,,,,, +15165807,4976,,related to,,Ergocalciferol,,,,postmenopausal osteoporosis,,,,, +14949967,4977,,related to,,Ergocalciferol,,,,Premature birth,,,,, +14949966,4978,,related to,,Ergocalciferol,,,,gestational diabetes,,,,, +14870236,4979,,related to,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, +14594285,4980,,related to,,Ergocalciferol,,,,colorectal neoplasm,,,,, +14321159,4981,,related to,,Ergocalciferol,,,,asthma,,,,, +13975664,4982,,related to,,Ergocalciferol,,,,cutaneous lupus erythematosus,,,,, +13939480,4983,,related to,,Ergocalciferol,,,,mood disorder,,,,, +13895667,4984,,related to,,Ergocalciferol,,,,sudden cardiac arrest,,,,, +13383363,4985,,related to,,Ergocalciferol,,,,sickle cell anemia,,,,, +13199782,4986,,related to,,Ergocalciferol,,,,Alzheimer disease,,,,, +12834035,4987,,related to,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +12803681,4988,,related to,,Ergocalciferol,,,,Insulin resistance,,,,, +12377378,4989,,related to,,Ergocalciferol,,,,non-Hodgkin lymphoma,,,,, +12131992,4990,,related to,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +11979233,4991,,related to,,Ergocalciferol,,,,leukemia,,,,, +11933002,4992,,related to,,Ergocalciferol,,,,Pain,,,,, +11653558,4993,,related to,,Ergocalciferol,,,,melanoma,,,,, +11434397,4994,,related to,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +11002964,4995,,related to,,Ergocalciferol,,,,pulmonary tuberculosis,,,,, +10894479,4996,,related to,,Ergocalciferol,,,,Crohn disease,,,,, +10768947,4997,,related to,,Ergocalciferol,,,,hip fracture,,,,, +10183383,4998,,related to,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +10168534,4999,,related to,,Ergocalciferol,,,,tuberculosis,,,,, +10066878,5000,,related to,,Ergocalciferol,,,,lymphoma,,,,, +9770434,1,,related to,,Ergocalciferol,,,,neoplasm,,,,, +9499640,2,,related to,,Ergocalciferol,,,,hypoparathyroidism,,,,, +9487308,3,,related to,,Ergocalciferol,,,,myocardial ischemia,,,,, +9462983,4,,related to,,Ergocalciferol,,,,ulcerative colitis,,,,, +9176947,5,,related to,,Ergocalciferol,,,,psoriasis,,,,, +9137351,6,,related to,,Ergocalciferol,,,,nutritional disorder,,,,, +8792180,7,,related to,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +8116213,8,,related to,,Ergocalciferol,,,,obesity disorder,,,,, +8093753,9,,related to,,Ergocalciferol,,,,vitamin D deficiency,,,,, +8061037,10,,related to,,Ergocalciferol,,,,multiple sclerosis,,,,, +8061036,11,,related to,,Ergocalciferol,,,,diabetes mellitus,,,,, +7613246,12,,related to,,Ergocalciferol,,,,osteoporosis,,,,, +7587226,13,,related to,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, +7252642,14,,related to,,Ergocalciferol,,,,prostate cancer,,,,, +26403196,15,,causes,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +25624374,16,,causes,,Ergocalciferol,,,,leukemia,,,,, +25513025,17,,causes,,Ergocalciferol,,,,restless legs syndrome,,,,, +25147512,18,,causes,,Ergocalciferol,,,,sarcopenia,,,,, +21420546,19,,causes,,Ergocalciferol,,,,diabetic neuropathy,,,,, +21344725,20,,causes,,Ergocalciferol,,,,diffuse alopecia areata,,,,, +19221130,21,,causes,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, +19022139,22,,causes,,Ergocalciferol,,,,gestational diabetes,,,,, +18967408,23,,causes,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, +18875338,24,,causes,,Ergocalciferol,,,,psoriasis,,,,, +18041148,25,,causes,,Ergocalciferol,,,,Crohn disease,,,,, +16369420,26,,causes,,Ergocalciferol,,,,neoplasm,,,,, +16017645,27,,causes,,Ergocalciferol,,,,obesity disorder,,,,, +15862130,28,,causes,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +15179909,29,,causes,,Ergocalciferol,,,,asthma,,,,, +14594790,30,,causes,,Ergocalciferol,,,,Insulin resistance,,,,, +14004176,31,,causes,,Ergocalciferol,,,,Pain,,,,, +12191251,32,,causes,,Ergocalciferol,,,,osteoporosis,,,,, +11612180,33,,causes,,Ergocalciferol,,,,colorectal neoplasm,,,,, +11557471,34,,causes,,Ergocalciferol,,,,vitamin D deficiency,,,,, +11557464,35,,causes,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +11275618,36,,causes,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +10362733,37,,causes,,Ergocalciferol,,,,multiple sclerosis,,,,, +8719466,38,,causes,,Ergocalciferol,,,,diabetes mellitus,,,,, +8407906,39,,causes,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +7553325,40,,causes,,Ergocalciferol,,,,prostate cancer,,,,, +7357695,41,,causes,,Ergocalciferol,,,,bone fracture,,,,, +25936029,42,,affects,,Ergocalciferol,,,,nutritional disorder,,,,, +25430100,43,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +24682916,44,,affects,,Ergocalciferol,,,,bone fracture,,,,, +24133915,45,,affects,,Ergocalciferol,,,,HIV infectious disease,,,,, +23716846,46,,affects,,Ergocalciferol,,,,Premature birth,,,,, +22436428,47,,affects,,Ergocalciferol,,,,obesity disorder,,,,, +22382447,48,,affects,,Ergocalciferol,,,,Pregnancy,,,,, +21132793,49,,affects,,Ergocalciferol,,,,breast neoplasm,,,,, +20959246,50,,affects,,Ergocalciferol,,,,diabetes mellitus,,,,, +20298561,51,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +20058982,52,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, +19907316,53,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, +19815602,54,,affects,,Ergocalciferol,,,,ulcerative colitis,,,,, +19320344,55,,affects,,Ergocalciferol,,,,Premature birth,,,,, +19221129,56,,affects,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, +18424308,57,,affects,,Ergocalciferol,,,,vitamin D deficiency,,,,, +18115621,58,,affects,,Ergocalciferol,,,,asthma,,,,, +17654393,59,,affects,,Ergocalciferol,,,,optic neuritis,,,,, +17646826,60,,affects,,Ergocalciferol,,,,migraine disorder,,,,, +17581908,61,,affects,,Ergocalciferol,,,,Pain,,,,, +17056932,62,,affects,,Ergocalciferol,,,,sarcopenia,,,,, +16630786,63,,affects,,Ergocalciferol,,,,sarcopenia,,,,, +16542255,64,,affects,,Ergocalciferol,,,,melanoma,,,,, +16343274,65,,affects,,Ergocalciferol,,,,restless legs syndrome,,,,, +16273798,66,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, +16273796,67,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +15812657,68,,affects,,Ergocalciferol,,,,prostate cancer,,,,, +15750325,69,,affects,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, +15694248,70,,affects,,Ergocalciferol,,,,mood disorder,,,,, +15543952,71,,affects,,Ergocalciferol,,,,osteoporosis,,,,, +15528071,72,,affects,,Ergocalciferol,,,,Alzheimer disease,,,,, +15258155,73,,affects,,Ergocalciferol,,,,obesity disorder,,,,, +14609756,74,,affects,,Ergocalciferol,,,,tuberculosis,,,,, +14384550,75,,affects,,Ergocalciferol,,,,psoriasis,,,,, +14233188,76,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, +13916047,77,,affects,,Ergocalciferol,,,,hip fracture,,,,, +13794313,78,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, +13764162,79,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +13437693,80,,affects,,Ergocalciferol,,,,Crohn disease,,,,, +13211992,81,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +13015298,82,,affects,,Ergocalciferol,,,,asthma,,,,, +12698804,83,,affects,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, +12502345,84,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +12032067,85,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, +11831475,86,,affects,,Ergocalciferol,,,,bone fracture,,,,, +10991167,87,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +10917919,88,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +10608353,89,,affects,,Ergocalciferol,,,,Pregnancy,,,,, +8987937,90,,affects,,Ergocalciferol,,,,hip fracture,,,,, +8925552,91,,affects,,Ergocalciferol,,,,prostate cancer,,,,, +8894668,92,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +8321224,93,,affects,,Ergocalciferol,,,,neoplasm,,,,, +7878820,94,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +21952380,95,,produces,,Ergocalciferol,,,,obesity disorder,,,,, +21636964,96,,produces,,Ergocalciferol,,,,asthma,,,,, +20636497,97,,produces,,Ergocalciferol,,,,Pregnancy,,,,, +20444810,98,,produces,,Ergocalciferol,,,,Alzheimer disease,,,,, +15318015,99,,produces,,Ergocalciferol,,,,melanoma,,,,, +14384547,100,,produces,,Ergocalciferol,,,,psoriasis,,,,, \ No newline at end of file diff --git a/false_labeled_records.csv b/false_labeled_records.csv index 1b957ff..6f9d84e 100644 --- a/false_labeled_records.csv +++ b/false_labeled_records.csv @@ -398,4603 +398,4603 @@ 24691450,Methylprednisolone related to plantar fasciitis,498,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,"Is the triple ""Methylprednisolone related to plantar fasciitis"" supported by the sentence: ""A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.""?",False, 24586108,Methylprednisolone related to alcoholic hepatitis,499,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,"Is the triple ""Methylprednisolone related to alcoholic hepatitis"" supported by the sentence: ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.""?",False, 24559507,Methylprednisolone related to respiratory system disorder,500,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,"Is the triple ""Methylprednisolone related to respiratory system disorder"" supported by the sentence: ""[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].""?",False, -23573980,Methylprednisolone related to pneumonia,1,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,"Is the triple ""Methylprednisolone related to pneumonia"" supported by the sentence: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?",False, -23514846,Methylprednisolone related to carpal tunnel syndrome,2,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,"Is the triple ""Methylprednisolone related to carpal tunnel syndrome"" supported by the sentence: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?",False, -23364897,Methylprednisolone related to West syndrome,3,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,"Is the triple ""Methylprednisolone related to West syndrome"" supported by the sentence: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?",False, -22495910,Methylprednisolone related to myocarditis,4,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,"Is the triple ""Methylprednisolone related to myocarditis"" supported by the sentence: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?",False, -22175056,Methylprednisolone related to myopathy,5,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.","Is the triple ""Methylprednisolone related to myopathy"" supported by the sentence: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?",False, -20879022,Methylprednisolone related to Pain,6,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.","Is the triple ""Methylprednisolone related to Pain"" supported by the sentence: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?",False, -20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,"Is the triple ""Methylprednisolone related to chronic progressive multiple sclerosis"" supported by the sentence: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?",False, -20290784,Methylprednisolone related to membranous glomerulonephritis,8,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,"Is the triple ""Methylprednisolone related to membranous glomerulonephritis"" supported by the sentence: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?",False, -20286711,Methylprednisolone related to neuromyelitis optica,9,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".","Is the triple ""Methylprednisolone related to neuromyelitis optica"" supported by the sentence: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?",False, -19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,"Is the triple ""Methylprednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?",False, -18938435,Methylprednisolone related to graft versus host disease,11,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,"Is the triple ""Methylprednisolone related to graft versus host disease"" supported by the sentence: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?",False, -17333962,Methylprednisolone related to Inflammation,12,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,"Is the triple ""Methylprednisolone related to Inflammation"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?",False, -17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,"Is the triple ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?",False, -15936572,Methylprednisolone related to endocrine exophthalmos,14,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,"Is the triple ""Methylprednisolone related to endocrine exophthalmos"" supported by the sentence: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?",False, -15072844,Methylprednisolone related to Edema,15,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.","Is the triple ""Methylprednisolone related to Edema"" supported by the sentence: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?",False, -14876749,Methylprednisolone related to osteoarthritis,16,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,"Is the triple ""Methylprednisolone related to osteoarthritis"" supported by the sentence: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?",False, -14399082,Methylprednisolone related to aplastic anemia,17,Long-term results of high-dose methylprednisolone in aplastic anemia.,"Is the triple ""Methylprednisolone related to aplastic anemia"" supported by the sentence: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?",False, -14398237,Methylprednisolone related to IgA glomerulonephritis,18,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.","Is the triple ""Methylprednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?",False, -14278238,"Methylprednisolone related to dermatitis, atopic",19,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.","Is the triple ""Methylprednisolone related to dermatitis, atopic"" supported by the sentence: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?",False, -14166179,Methylprednisolone related to cardiac arrest,20,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.","Is the triple ""Methylprednisolone related to cardiac arrest"" supported by the sentence: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?",False, -12755316,Methylprednisolone related to plasma cell myeloma,21,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,"Is the triple ""Methylprednisolone related to plasma cell myeloma"" supported by the sentence: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?",False, -12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,"Is the triple ""Methylprednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?",False, -11720471,Methylprednisolone related to systemic lupus erythematosus,23,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,"Is the triple ""Methylprednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?",False, -10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,"Is the triple ""Methylprednisolone related to immunoglobulin a vasculitis"" supported by the sentence: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?",False, -10763477,Methylprednisolone related to ulcerative colitis,25,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,"Is the triple ""Methylprednisolone related to ulcerative colitis"" supported by the sentence: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?",False, -10558884,Methylprednisolone related to lupus nephritis,26,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,"Is the triple ""Methylprednisolone related to lupus nephritis"" supported by the sentence: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?",False, -10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.","Is the triple ""Methylprednisolone related to adult acute respiratory distress syndrome"" supported by the sentence: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?",False, -9229208,Methylprednisolone related to vestibular neuronitis,28,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.","Is the triple ""Methylprednisolone related to vestibular neuronitis"" supported by the sentence: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?",False, -9003326,Methylprednisolone related to systemic sclerosis,29,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,"Is the triple ""Methylprednisolone related to systemic sclerosis"" supported by the sentence: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?",False, -8447481,Methylprednisolone related to rheumatoid arthritis,30,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,"Is the triple ""Methylprednisolone related to rheumatoid arthritis"" supported by the sentence: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?",False, -8282330,Methylprednisolone related to spinal cord injury,31,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.","Is the triple ""Methylprednisolone related to spinal cord injury"" supported by the sentence: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?",False, -7944646,Methylprednisolone related to myasthenia gravis,32,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,"Is the triple ""Methylprednisolone related to myasthenia gravis"" supported by the sentence: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?",False, -7668599,Methylprednisolone related to multiple sclerosis,33,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,"Is the triple ""Methylprednisolone related to multiple sclerosis"" supported by the sentence: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?",False, -7443745,Methylprednisolone related to asthma,34,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.","Is the triple ""Methylprednisolone related to asthma"" supported by the sentence: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?",False, -24973247,Methylprednisolone causes lupus nephritis,35,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.","Is the triple ""Methylprednisolone causes lupus nephritis"" supported by the sentence: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?",False, -24161886,Methylprednisolone causes Edema,36,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,"Is the triple ""Methylprednisolone causes Edema"" supported by the sentence: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?",False, -18534953,Methylprednisolone causes Inflammation,37,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.","Is the triple ""Methylprednisolone causes Inflammation"" supported by the sentence: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?",False, -18260665,Methylprednisolone causes neoplasm,38,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,"Is the triple ""Methylprednisolone causes neoplasm"" supported by the sentence: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?",False, -17307095,Methylprednisolone causes pneumonia,39,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.","Is the triple ""Methylprednisolone causes pneumonia"" supported by the sentence: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?",False, -15906641,Methylprednisolone causes Pain,40,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,"Is the triple ""Methylprednisolone causes Pain"" supported by the sentence: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?",False, -13166073,Methylprednisolone causes thrombocytopenia,41,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.","Is the triple ""Methylprednisolone causes thrombocytopenia"" supported by the sentence: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?",False, -12672767,Methylprednisolone causes drug-induced liver injury,42,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.","Is the triple ""Methylprednisolone causes drug-induced liver injury"" supported by the sentence: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?",False, -8525599,Methylprednisolone causes myopathy,43,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.","Is the triple ""Methylprednisolone causes myopathy"" supported by the sentence: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?",False, -27357949,Methylprednisolone affects neoplasm,44,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.","Is the triple ""Methylprednisolone affects neoplasm"" supported by the sentence: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?",False, -24420470,Methylprednisolone affects Inflammation,45,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.","Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?",False, -23472756,Methylprednisolone affects Inflammation,46,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,"Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?",False, -20530617,Methylprednisolone affects systemic sclerosis,47,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.","Is the triple ""Methylprednisolone affects systemic sclerosis"" supported by the sentence: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?",False, -20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.","Is the triple ""Methylprednisolone affects adult acute respiratory distress syndrome"" supported by the sentence: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?",False, -17649050,Methylprednisolone affects optic nerve disorder,49,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,"Is the triple ""Methylprednisolone affects optic nerve disorder"" supported by the sentence: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?",False, -16634377,Methylprednisolone affects myasthenia gravis,50,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,"Is the triple ""Methylprednisolone affects myasthenia gravis"" supported by the sentence: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?",False, -16277488,Methylprednisolone affects neuromyelitis optica,51,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,"Is the triple ""Methylprednisolone affects neuromyelitis optica"" supported by the sentence: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?",False, -15906642,Methylprednisolone affects Pain,52,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?",False, -15610554,Methylprednisolone affects rheumatoid arthritis,53,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,"Is the triple ""Methylprednisolone affects rheumatoid arthritis"" supported by the sentence: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?",False, -15186368,Methylprednisolone affects graft versus host disease,54,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,"Is the triple ""Methylprednisolone affects graft versus host disease"" supported by the sentence: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?",False, -14891106,Methylprednisolone affects kidney disorder,55,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.","Is the triple ""Methylprednisolone affects kidney disorder"" supported by the sentence: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?",False, -11819955,Methylprednisolone affects spinal cord injury,56,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.","Is the triple ""Methylprednisolone affects spinal cord injury"" supported by the sentence: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?",False, -10845505,Methylprednisolone affects Pain,57,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?",False, -10048898,Methylprednisolone affects ulcerative colitis,58,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,"Is the triple ""Methylprednisolone affects ulcerative colitis"" supported by the sentence: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?",False, -9646753,Methylprednisolone affects multiple sclerosis,59,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,"Is the triple ""Methylprednisolone affects multiple sclerosis"" supported by the sentence: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?",False, -9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).","Is the triple ""Methylprednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?",False, -9107378,Methylprednisolone affects Edema,61,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.","Is the triple ""Methylprednisolone affects Edema"" supported by the sentence: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?",False, -8596544,Methylprednisolone affects asthma,62,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,"Is the triple ""Methylprednisolone affects asthma"" supported by the sentence: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?",False, -8330909,Methylprednisolone affects systemic lupus erythematosus,63,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,"Is the triple ""Methylprednisolone affects systemic lupus erythematosus"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?",False, -19744632,Methylprednisolone disrupts Edema,64,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.","Is the triple ""Methylprednisolone disrupts Edema"" supported by the sentence: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?",False, -18407557,Methylprednisolone disrupts thrombocytopenia,65,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,"Is the triple ""Methylprednisolone disrupts thrombocytopenia"" supported by the sentence: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?",False, -11106658,Methylprednisolone disrupts Pain,66,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.","Is the triple ""Methylprednisolone disrupts Pain"" supported by the sentence: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?",False, -8640603,Methylprednisolone disrupts Inflammation,67,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,"Is the triple ""Methylprednisolone disrupts Inflammation"" supported by the sentence: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?",False, -23934495,Methylprednisolone prevents Cognitive impairment,68,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.","Is the triple ""Methylprednisolone prevents Cognitive impairment"" supported by the sentence: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?",False, -20014108,Methylprednisolone prevents rheumatoid arthritis,69,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).","Is the triple ""Methylprednisolone prevents rheumatoid arthritis"" supported by the sentence: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?",False, -18266414,Methylprednisolone prevents Abdominal pain,70,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,"Is the triple ""Methylprednisolone prevents Abdominal pain"" supported by the sentence: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?",False, -14967074,Methylprednisolone prevents asthma,71,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,"Is the triple ""Methylprednisolone prevents asthma"" supported by the sentence: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?",False, -9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,"Is the triple ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?",False, -8345063,Methylprednisolone prevents Pain,73,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.","Is the triple ""Methylprednisolone prevents Pain"" supported by the sentence: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?",False, -8291272,Methylprednisolone prevents graft versus host disease,74,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,"Is the triple ""Methylprednisolone prevents graft versus host disease"" supported by the sentence: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?",False, -7980138,Methylprednisolone prevents spinal cord injury,75,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.","Is the triple ""Methylprednisolone prevents spinal cord injury"" supported by the sentence: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?",False, -7414405,Methylprednisolone prevents Edema,76,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.","Is the triple ""Methylprednisolone prevents Edema"" supported by the sentence: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?",False, -18106042,Methylprednisolone predisposes pneumonia,77,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,"Is the triple ""Methylprednisolone predisposes pneumonia"" supported by the sentence: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?",False, -9645180,Methylprednisolone predisposes Inflammation,78,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.","Is the triple ""Methylprednisolone predisposes Inflammation"" supported by the sentence: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?",False, -12905337,Cefotaxime related to Sepsis,79,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.","Is the triple ""Cefotaxime related to Sepsis"" supported by the sentence: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?",False, -24475300,Cefotaxime affects bacterial infectious disease,80,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.","Is the triple ""Cefotaxime affects bacterial infectious disease"" supported by the sentence: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?",False, -23922029,Cefotaxime affects Sepsis,81,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).","Is the triple ""Cefotaxime affects Sepsis"" supported by the sentence: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?",False, -18672205,Cefotaxime affects peritonitis,82,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.","Is the triple ""Cefotaxime affects peritonitis"" supported by the sentence: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?",False, -15853591,Cefotaxime prevents Sepsis,83,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.","Is the triple ""Cefotaxime prevents Sepsis"" supported by the sentence: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?",False, -19081412,Ceftriaxone prevents bacterial infectious disease,84,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.","Is the triple ""Ceftriaxone prevents bacterial infectious disease"" supported by the sentence: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?",False, -25827448,Gefarnate related to gastric ulcer,85,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,"Is the triple ""Gefarnate related to gastric ulcer"" supported by the sentence: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?",False, -24296137,Gefarnate related to duodenal ulcer,86,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,"Is the triple ""Gefarnate related to duodenal ulcer"" supported by the sentence: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?",False, -25993651,Gefarnate disrupts gastric ulcer,87,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,"Is the triple ""Gefarnate disrupts gastric ulcer"" supported by the sentence: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?",False, -17758516,Neobiotic related to Inflammation,88,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,"Is the triple ""Neobiotic related to Inflammation"" supported by the sentence: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?",False, -10690423,Neobiotic related to burn,89,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,"Is the triple ""Neobiotic related to burn"" supported by the sentence: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?",False, -20263460,Neobiotic affects neoplasm,90,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.","Is the triple ""Neobiotic affects neoplasm"" supported by the sentence: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?",False, -19744068,Neobiotic affects Inflammation,91,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,"Is the triple ""Neobiotic affects Inflammation"" supported by the sentence: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?",False, -24669492,Neobiotic disrupts bacterial infectious disease,92,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.","Is the triple ""Neobiotic disrupts bacterial infectious disease"" supported by the sentence: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?",False, -17119153,Neobiotic disrupts neoplasm,93,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,"Is the triple ""Neobiotic disrupts neoplasm"" supported by the sentence: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?",False, -26428369,Neobiotic prevents bacterial infectious disease,94,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Neobiotic prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, -25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,"Is the triple ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" supported by the sentence: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?",False, -22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.","Is the triple ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?",False, -21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,"Is the triple ""BLINATUMOMAB related to acute lymphoblastic leukemia"" supported by the sentence: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?",False, -27155094,Ciprofloxacin related to endophthalmitis,98,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,"Is the triple ""Ciprofloxacin related to endophthalmitis"" supported by the sentence: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?",False, -16836665,Ciprofloxacin related to Crohn disease,99,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,"Is the triple ""Ciprofloxacin related to Crohn disease"" supported by the sentence: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?",False, -19572117,Ciprofloxacin related to DNA Gyrase,100,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, -19572117,Ciprofloxacin related to DNA Gyrase,101,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, -12385742,Ciprofloxacin coexists with DNA Gyrase,102,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, -12385742,Ciprofloxacin coexists with DNA Gyrase,103,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, -17007621,Ciprofloxacin coexists with DNA Gyrase,104,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, -17007621,Ciprofloxacin coexists with DNA Gyrase,105,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, -9387116,Ciprofloxacin physically interacts with DNA Gyrase,106,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.","Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.""?",False, -8212496,Ciprofloxacin physically interacts with DNA Gyrase,107,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,"Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.""?",False, -25648466,Ciprofloxacin causes abscess,108,Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.,"Is the triple ""Ciprofloxacin causes abscess"" supported by the sentence: ""Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.""?",False, -24716241,Ciprofloxacin causes peritonitis,109,The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.,"Is the triple ""Ciprofloxacin causes peritonitis"" supported by the sentence: ""The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.""?",False, -17154464,Ciprofloxacin causes prostatitis,110,"After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).","Is the triple ""Ciprofloxacin causes prostatitis"" supported by the sentence: ""After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).""?",False, -14369807,Ciprofloxacin causes neutropenia,111,[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].,"Is the triple ""Ciprofloxacin causes neutropenia"" supported by the sentence: ""[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].""?",False, -13950319,Ciprofloxacin causes pneumonia,112,"According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.","Is the triple ""Ciprofloxacin causes pneumonia"" supported by the sentence: ""According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.""?",False, -10209213,Ciprofloxacin causes infectious disease,113,"Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.","Is the triple ""Ciprofloxacin causes infectious disease"" supported by the sentence: ""Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.""?",False, -7113733,Ciprofloxacin causes osteomyelitis,114,A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.,"Is the triple ""Ciprofloxacin causes osteomyelitis"" supported by the sentence: ""A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.""?",False, -21996198,Ciprofloxacin affects infectious disease,115,Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.,"Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.""?",False, -16563368,Ciprofloxacin affects Fever,116,"Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.""?",False, -16125923,Ciprofloxacin affects osteomyelitis,117,"Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.","Is the triple ""Ciprofloxacin affects osteomyelitis"" supported by the sentence: ""Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.""?",False, -12942741,Ciprofloxacin affects Crohn disease,118,BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.,"Is the triple ""Ciprofloxacin affects Crohn disease"" supported by the sentence: ""BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.""?",False, -11440816,Ciprofloxacin affects typhoid fever,119,A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.,"Is the triple ""Ciprofloxacin affects typhoid fever"" supported by the sentence: ""A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.""?",False, -11267024,Ciprofloxacin affects eye infectious disorder,120,The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).,"Is the triple ""Ciprofloxacin affects eye infectious disorder"" supported by the sentence: ""The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).""?",False, -10672042,Ciprofloxacin affects Abdominal Infection,121,The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.,"Is the triple ""Ciprofloxacin affects Abdominal Infection"" supported by the sentence: ""The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.""?",False, -9891814,Ciprofloxacin affects pneumonia,122,"This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.","Is the triple ""Ciprofloxacin affects pneumonia"" supported by the sentence: ""This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.""?",False, -9122989,Ciprofloxacin affects infectious disease,123,"The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.","Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.""?",False, -8956826,Ciprofloxacin affects Pseudomonas infection,124,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects Pseudomonas infection"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, -8956825,Ciprofloxacin affects cystic fibrosis,125,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects cystic fibrosis"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, -8669720,Ciprofloxacin affects Fever,126,"(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.""?",False, -7886704,Ciprofloxacin affects bronchiectasis,127,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects bronchiectasis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, -7886701,Ciprofloxacin affects chronic bronchitis,128,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects chronic bronchitis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, -7781719,Ciprofloxacin affects DNA Gyrase,129,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.","Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.""?",False, -7592205,Ciprofloxacin affects chronic obstructive pulmonary disease,130,"Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.","Is the triple ""Ciprofloxacin affects chronic obstructive pulmonary disease"" supported by the sentence: ""Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.""?",False, -18400322,Ciprofloxacin affects DNA Gyrase,131,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,"Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.""?",False, -26984478,Ciprofloxacin disrupts Fever,132,"In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.","Is the triple ""Ciprofloxacin disrupts Fever"" supported by the sentence: ""In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.""?",False, -26466958,Ciprofloxacin disrupts pneumonia,133,"At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.","Is the triple ""Ciprofloxacin disrupts pneumonia"" supported by the sentence: ""At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.""?",False, -18480207,Ciprofloxacin disrupts infectious disease,134,"We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.","Is the triple ""Ciprofloxacin disrupts infectious disease"" supported by the sentence: ""We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.""?",False, -10323767,Ciprofloxacin disrupts bacterial infectious disease with sepsis,135,Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.,"Is the triple ""Ciprofloxacin disrupts bacterial infectious disease with sepsis"" supported by the sentence: ""Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.""?",False, -27242944,Ciprofloxacin prevents pyelonephritis,136,"In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.","Is the triple ""Ciprofloxacin prevents pyelonephritis"" supported by the sentence: ""In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.""?",False, -21807033,Ciprofloxacin prevents Infection,137,25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.,"Is the triple ""Ciprofloxacin prevents Infection"" supported by the sentence: ""25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.""?",False, -16138544,Ciprofloxacin prevents diarrheal disease,138,"Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.","Is the triple ""Ciprofloxacin prevents diarrheal disease"" supported by the sentence: ""Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.""?",False, -15438014,Ciprofloxacin prevents Sepsis,139,"CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.","Is the triple ""Ciprofloxacin prevents Sepsis"" supported by the sentence: ""CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.""?",False, -14202377,Ciprofloxacin prevents plague,140,"Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.","Is the triple ""Ciprofloxacin prevents plague"" supported by the sentence: ""Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.""?",False, -12292532,Ciprofloxacin prevents endophthalmitis,141,These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.,"Is the triple ""Ciprofloxacin prevents endophthalmitis"" supported by the sentence: ""These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.""?",False, -10767980,Ciprofloxacin prevents bacterial infectious disease with sepsis,142,"To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.","Is the triple ""Ciprofloxacin prevents bacterial infectious disease with sepsis"" supported by the sentence: ""To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.""?",False, -9947057,Ciprofloxacin prevents bacterial infectious disease,143,[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].,"Is the triple ""Ciprofloxacin prevents bacterial infectious disease"" supported by the sentence: ""[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].""?",False, -8364719,Ciprofloxacin prevents pneumonia,144,The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.,"Is the triple ""Ciprofloxacin prevents pneumonia"" supported by the sentence: ""The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.""?",False, -8054296,Ciprofloxacin prevents infectious disease,145,"PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.","Is the triple ""Ciprofloxacin prevents infectious disease"" supported by the sentence: ""PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.""?",False, -18366035,Ciprofloxacin predisposes infectious disease,146,"Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.","Is the triple ""Ciprofloxacin predisposes infectious disease"" supported by the sentence: ""Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.""?",False, -15459841,Ciprofloxacin predisposes bacterial infectious disease with sepsis,147,"CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.","Is the triple ""Ciprofloxacin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.""?",False, -8758764,Ciprofloxacin predisposes gonorrhea,148,These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.,"Is the triple ""Ciprofloxacin predisposes gonorrhea"" supported by the sentence: ""These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.""?",False, -15493028,Chloramphenicol disrupts acne,149,Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.,"Is the triple ""Chloramphenicol disrupts acne"" supported by the sentence: ""Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.""?",False, -21241586,Chloramphenicol prevents eye infectious disorder,150,"Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.","Is the triple ""Chloramphenicol prevents eye infectious disorder"" supported by the sentence: ""Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.""?",False, -16722213,Rebamipide causes osteoarthritis,151,Oral administration of rebamipide was initiated on the day of OA induction.,"Is the triple ""Rebamipide causes osteoarthritis"" supported by the sentence: ""Oral administration of rebamipide was initiated on the day of OA induction.""?",False, -27679650,Rebamipide affects peptic ulcer disease,152,Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.,"Is the triple ""Rebamipide affects peptic ulcer disease"" supported by the sentence: ""Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.""?",False, -10125846,Rebamipide affects gastric ulcer,153,Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.,"Is the triple ""Rebamipide affects gastric ulcer"" supported by the sentence: ""Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.""?",False, -16923576,Rebamipide disrupts gastritis,154,"Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.","Is the triple ""Rebamipide disrupts gastritis"" supported by the sentence: ""Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.""?",False, -20953135,Rebamipide prevents peptic ulcer disease,155,CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).,"Is the triple ""Rebamipide prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).""?",False, -13727344,Rebamipide prevents gastritis,156,Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.,"Is the triple ""Rebamipide prevents gastritis"" supported by the sentence: ""Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.""?",False, -10452606,Rebamipide prevents gastric ulcer,157,These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.,"Is the triple ""Rebamipide prevents gastric ulcer"" supported by the sentence: ""These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.""?",False, -23020953,DINUTUXIMAB related to neoplasm,158,"In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.","Is the triple ""DINUTUXIMAB related to neoplasm"" supported by the sentence: ""In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.""?",False, -12385638,DINUTUXIMAB related to neuroblastoma,159,The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.,"Is the triple ""DINUTUXIMAB related to neuroblastoma"" supported by the sentence: ""The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.""?",False, -21974466,DINUTUXIMAB causes neuroblastoma,160,Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.,"Is the triple ""DINUTUXIMAB causes neuroblastoma"" supported by the sentence: ""Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.""?",False, -23929422,BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma,161,INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).,"Is the triple ""BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma"" supported by the sentence: ""INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).""?",False, -23730531,BRENTUXIMAB VEDOTIN related to mycosis fungoides,162,"These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to mycosis fungoides"" supported by the sentence: ""These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.""?",False, -23653011,BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma,163,Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.,"Is the triple ""BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma"" supported by the sentence: ""Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.""?",False, -23065539,BRENTUXIMAB VEDOTIN related to lymphoma,164,"Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to lymphoma"" supported by the sentence: ""Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.""?",False, -21812241,BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma,165,Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.,"Is the triple ""BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma"" supported by the sentence: ""Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.""?",False, -21657994,BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma,166,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, -21657993,BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma,167,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, -22071488,BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma,168,Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.,"Is the triple ""BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.""?",False, -21553377,BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma,169,"Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.","Is the triple ""BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma"" supported by the sentence: ""Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.""?",False, -23435913,BRENTUXIMAB VEDOTIN affects lymphoma,170,"Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.","Is the triple ""BRENTUXIMAB VEDOTIN affects lymphoma"" supported by the sentence: ""Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.""?",False, -20170701,Tetracycline causes periodontitis,171,"In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.","Is the triple ""Tetracycline causes periodontitis"" supported by the sentence: ""In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.""?",False, -19472933,Tetracycline causes Helicobacter pylori infectious disease,172,"In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.","Is the triple ""Tetracycline causes Helicobacter pylori infectious disease"" supported by the sentence: ""In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.""?",False, -18080767,Tetracycline affects periodontitis,173,Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.,"Is the triple ""Tetracycline affects periodontitis"" supported by the sentence: ""Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.""?",False, -17969405,Tetracycline affects bacterial infectious disease,174,"We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.","Is the triple ""Tetracycline affects bacterial infectious disease"" supported by the sentence: ""We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.""?",False, -24565223,Tetracycline prevents bacterial infectious disease,175,"Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .","Is the triple ""Tetracycline prevents bacterial infectious disease"" supported by the sentence: ""Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .""?",False, -10847016,Tetracycline prevents inclusion conjunctivitis,176,"Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.","Is the triple ""Tetracycline prevents inclusion conjunctivitis"" supported by the sentence: ""Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.""?",False, -12376615,(Alginate)n related to gastroesophageal reflux disease,177,Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.,"Is the triple ""(Alginate)n related to gastroesophageal reflux disease"" supported by the sentence: ""Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.""?",False, -11754791,(Alginate)n related to cystic fibrosis,178,Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.,"Is the triple ""(Alginate)n related to cystic fibrosis"" supported by the sentence: ""Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.""?",False, -10599430,(Alginate)n related to obesity disorder,179,[Alginate--skimmed milk mixture as an aid in obesity].,"Is the triple ""(Alginate)n related to obesity disorder"" supported by the sentence: ""[Alginate--skimmed milk mixture as an aid in obesity].""?",False, -27435796,(Alginate)n affects cystic fibrosis,180,"Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.","Is the triple ""(Alginate)n affects cystic fibrosis"" supported by the sentence: ""Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.""?",False, -27132270,(Alginate)n affects gastroesophageal reflux disease,181,Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.""?",False, -23415127,(Alginate)n affects obesity disorder,182,"Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.","Is the triple ""(Alginate)n affects obesity disorder"" supported by the sentence: ""Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.""?",False, -19854419,(Alginate)n affects gastroesophageal reflux disease,183,Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.""?",False, -8246131,(Alginate)n disrupts gastroesophageal reflux disease,184,"Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.","Is the triple ""(Alginate)n disrupts gastroesophageal reflux disease"" supported by the sentence: ""Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.""?",False, -11492096,(Alginate)n prevents gastroesophageal reflux disease,185,Alginic acid decreases postprandial upright gastroesophageal reflux.,"Is the triple ""(Alginate)n prevents gastroesophageal reflux disease"" supported by the sentence: ""Alginic acid decreases postprandial upright gastroesophageal reflux.""?",False, -23508922,(Alginate)n predisposes obesity disorder,186,The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.,"Is the triple ""(Alginate)n predisposes obesity disorder"" supported by the sentence: ""The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.""?",False, -11597598,Zolimidine related to peptic ulcer disease,187,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Zolimidine related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, -20742970,Chlorhexidine causes infectious disease,188,"Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.","Is the triple ""Chlorhexidine causes infectious disease"" supported by the sentence: ""Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.""?",False, -16147932,Chlorhexidine causes gingivitis,189,CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.,"Is the triple ""Chlorhexidine causes gingivitis"" supported by the sentence: ""CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.""?",False, -15413413,Chlorhexidine causes stomatitis,190,Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.,"Is the triple ""Chlorhexidine causes stomatitis"" supported by the sentence: ""Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.""?",False, -13735208,Chlorhexidine causes bacterial infectious disease with sepsis,191,Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.,"Is the triple ""Chlorhexidine causes bacterial infectious disease with sepsis"" supported by the sentence: ""Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.""?",False, -23793676,Chlorhexidine affects Infection,192,This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.,"Is the triple ""Chlorhexidine affects Infection"" supported by the sentence: ""This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.""?",False, -21319017,Chlorhexidine affects pneumonia,193,Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.,"Is the triple ""Chlorhexidine affects pneumonia"" supported by the sentence: ""Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.""?",False, -20585434,Chlorhexidine affects stomatitis,194,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Chlorhexidine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, -13503760,Chlorhexidine affects periodontal disorder,195,"Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.","Is the triple ""Chlorhexidine affects periodontal disorder"" supported by the sentence: ""Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.""?",False, -8506996,Chlorhexidine affects gingivitis,196,Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.,"Is the triple ""Chlorhexidine affects gingivitis"" supported by the sentence: ""Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.""?",False, -25489531,"Chlorhexidine disrupts Pneumonia, Ventilator-Associated",197,"Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).","Is the triple ""Chlorhexidine disrupts Pneumonia, Ventilator-Associated"" supported by the sentence: ""Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).""?",False, -22304373,Chlorhexidine disrupts dental caries,198,This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.,"Is the triple ""Chlorhexidine disrupts dental caries"" supported by the sentence: ""This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.""?",False, -21939464,Chlorhexidine disrupts Infection,199,"In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).","Is the triple ""Chlorhexidine disrupts Infection"" supported by the sentence: ""In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).""?",False, -19793680,Chlorhexidine disrupts bacterial infectious disease,200,This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.,"Is the triple ""Chlorhexidine disrupts bacterial infectious disease"" supported by the sentence: ""This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.""?",False, -18040358,Chlorhexidine disrupts infectious disease,201,Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.,"Is the triple ""Chlorhexidine disrupts infectious disease"" supported by the sentence: ""Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.""?",False, -11272633,Chlorhexidine disrupts gingivitis,202,The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.,"Is the triple ""Chlorhexidine disrupts gingivitis"" supported by the sentence: ""The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.""?",False, -26042520,Chlorhexidine prevents staphylococcal infection,203,"It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.","Is the triple ""Chlorhexidine prevents staphylococcal infection"" supported by the sentence: ""It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.""?",False, -22617089,Chlorhexidine prevents periodontitis,204,"Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.","Is the triple ""Chlorhexidine prevents periodontitis"" supported by the sentence: ""Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.""?",False, -22038778,Chlorhexidine prevents bacterial infectious disease,205,"CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.","Is the triple ""Chlorhexidine prevents bacterial infectious disease"" supported by the sentence: ""CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.""?",False, -22000060,Chlorhexidine prevents Infection,206,"Thus, CHX can be used to prevent subsequent biofilm infections.","Is the triple ""Chlorhexidine prevents Infection"" supported by the sentence: ""Thus, CHX can be used to prevent subsequent biofilm infections.""?",False, -21737487,"Chlorhexidine prevents Pneumonia, Ventilator-Associated",207,Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.,"Is the triple ""Chlorhexidine prevents Pneumonia, Ventilator-Associated"" supported by the sentence: ""Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.""?",False, -19905103,Chlorhexidine prevents periodontal disorder,208,"The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.","Is the triple ""Chlorhexidine prevents periodontal disorder"" supported by the sentence: ""The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.""?",False, -16765643,Chlorhexidine prevents Neonatal sepsis,209,AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).,"Is the triple ""Chlorhexidine prevents Neonatal sepsis"" supported by the sentence: ""AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).""?",False, -14052320,Chlorhexidine prevents pneumonia,210,Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.,"Is the triple ""Chlorhexidine prevents pneumonia"" supported by the sentence: ""Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.""?",False, -11830955,Chlorhexidine prevents bacterial infectious disease with sepsis,211,"Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.","Is the triple ""Chlorhexidine prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.""?",False, -11145796,Chlorhexidine prevents infectious disease,212,CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.,"Is the triple ""Chlorhexidine prevents infectious disease"" supported by the sentence: ""CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.""?",False, -10739867,Chlorhexidine prevents stomatitis,213,"The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.","Is the triple ""Chlorhexidine prevents stomatitis"" supported by the sentence: ""The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.""?",False, -10141569,Chlorhexidine prevents dental caries,214,The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.,"Is the triple ""Chlorhexidine prevents dental caries"" supported by the sentence: ""The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.""?",False, -7990742,Chlorhexidine prevents gingivitis,215,"Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.","Is the triple ""Chlorhexidine prevents gingivitis"" supported by the sentence: ""Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.""?",False, -23454202,"Chlorhexidine predisposes Pneumonia, Ventilator-Associated",216,"The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.","Is the triple ""Chlorhexidine predisposes Pneumonia, Ventilator-Associated"" supported by the sentence: ""The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.""?",False, -19942414,Chlorhexidine predisposes periodontal disorder,217,CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.,"Is the triple ""Chlorhexidine predisposes periodontal disorder"" supported by the sentence: ""CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.""?",False, -18735040,Chlorhexidine predisposes dental caries,218,"Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.","Is the triple ""Chlorhexidine predisposes dental caries"" supported by the sentence: ""Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.""?",False, -16765642,Chlorhexidine predisposes Neonatal sepsis,219,Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.,"Is the triple ""Chlorhexidine predisposes Neonatal sepsis"" supported by the sentence: ""Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.""?",False, -24905090,Nicergoline causes depressive disorder,220,"RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.","Is the triple ""Nicergoline causes depressive disorder"" supported by the sentence: ""RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.""?",False, -25103280,RAMUCIRUMAB related to hepatocellular carcinoma,221,"Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.","Is the triple ""RAMUCIRUMAB related to hepatocellular carcinoma"" supported by the sentence: ""Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.""?",False, -22612331,RAMUCIRUMAB related to neoplasm,222,"CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.","Is the triple ""RAMUCIRUMAB related to neoplasm"" supported by the sentence: ""CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.""?",False, -21600131,RAMUCIRUMAB related to non-small cell lung carcinoma,223,Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.,"Is the triple ""RAMUCIRUMAB related to non-small cell lung carcinoma"" supported by the sentence: ""Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.""?",False, -22008312,RAMUCIRUMAB affects neoplasm,224,"This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).","Is the triple ""RAMUCIRUMAB affects neoplasm"" supported by the sentence: ""This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).""?",False, -23569571,TAFASITAMAB related to diffuse large B-cell lymphoma,225,The use of tafasitamab in diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB related to diffuse large B-cell lymphoma"" supported by the sentence: ""The use of tafasitamab in diffuse large B-cell lymphoma.""?",False, -24533103,TAFASITAMAB disrupts diffuse large B-cell lymphoma,226,MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB disrupts diffuse large B-cell lymphoma"" supported by the sentence: ""MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.""?",False, -21884997,Thioctic acid related to cystinuria,227,alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.,"Is the triple ""Thioctic acid related to cystinuria"" supported by the sentence: ""alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.""?",False, -20207321,Thioctic acid related to chronic progressive multiple sclerosis,228,Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.,"Is the triple ""Thioctic acid related to chronic progressive multiple sclerosis"" supported by the sentence: ""Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.""?",False, -18115881,Thioctic acid related to hypertensive disorder,229,"INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.","Is the triple ""Thioctic acid related to hypertensive disorder"" supported by the sentence: ""INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.""?",False, -15406106,Thioctic acid related to optic neuritis,230,This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.,"Is the triple ""Thioctic acid related to optic neuritis"" supported by the sentence: ""This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.""?",False, -12204809,Thioctic acid related to type 2 diabetes mellitus,231,"As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.","Is the triple ""Thioctic acid related to type 2 diabetes mellitus"" supported by the sentence: ""As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.""?",False, -11741203,Thioctic acid related to multiple sclerosis,232,Lipoic acid in multiple sclerosis: a pilot study.,"Is the triple ""Thioctic acid related to multiple sclerosis"" supported by the sentence: ""Lipoic acid in multiple sclerosis: a pilot study.""?",False, -11010945,Thioctic acid related to AIDS,233,These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.,"Is the triple ""Thioctic acid related to AIDS"" supported by the sentence: ""These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.""?",False, -10648973,Thioctic acid related to skin disorder,234,[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].,"Is the triple ""Thioctic acid related to skin disorder"" supported by the sentence: ""[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].""?",False, -7603472,Thioctic acid related to diabetic neuropathy,235,[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].,"Is the triple ""Thioctic acid related to diabetic neuropathy"" supported by the sentence: ""[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].""?",False, -16842192,Thioctic acid causes hypertensive disorder,236,"AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.","Is the triple ""Thioctic acid causes hypertensive disorder"" supported by the sentence: ""AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.""?",False, -21111426,Thioctic acid affects optic neuritis,237,"Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.","Is the triple ""Thioctic acid affects optic neuritis"" supported by the sentence: ""Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.""?",False, -18505755,Thioctic acid affects diabetic neuropathy,238,"Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.","Is the triple ""Thioctic acid affects diabetic neuropathy"" supported by the sentence: ""Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.""?",False, -17198477,Thioctic acid affects type 2 diabetes mellitus,239,"A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.","Is the triple ""Thioctic acid affects type 2 diabetes mellitus"" supported by the sentence: ""A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.""?",False, -12393284,Thioctic acid affects Alzheimer disease,240,"The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.","Is the triple ""Thioctic acid affects Alzheimer disease"" supported by the sentence: ""The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.""?",False, -9028391,Thioctic acid affects hypertensive disorder,241,"Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.","Is the triple ""Thioctic acid affects hypertensive disorder"" supported by the sentence: ""Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.""?",False, -21111429,Thioctic acid prevents optic neuritis,242,Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.,"Is the triple ""Thioctic acid prevents optic neuritis"" supported by the sentence: ""Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.""?",False, -18775341,Thioctic acid prevents skin disorder,243,"Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.","Is the triple ""Thioctic acid prevents skin disorder"" supported by the sentence: ""Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.""?",False, -18076378,Thioctic acid prevents type 2 diabetes mellitus,244,"Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.","Is the triple ""Thioctic acid prevents type 2 diabetes mellitus"" supported by the sentence: ""Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.""?",False, -15377554,Thioctic acid prevents stroke disorder,245,We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.,"Is the triple ""Thioctic acid prevents stroke disorder"" supported by the sentence: ""We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.""?",False, -13878249,Thioctic acid prevents Alzheimer disease,246,Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.,"Is the triple ""Thioctic acid prevents Alzheimer disease"" supported by the sentence: ""Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.""?",False, -8826102,Thioctic acid prevents hypertensive disorder,247,"The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.","Is the triple ""Thioctic acid prevents hypertensive disorder"" supported by the sentence: ""The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.""?",False, -8682086,Thioctic acid prevents diabetic neuropathy,248,alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.,"Is the triple ""Thioctic acid prevents diabetic neuropathy"" supported by the sentence: ""alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.""?",False, -15385084,Thioctic acid predisposes Alzheimer disease,249,"Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.","Is the triple ""Thioctic acid predisposes Alzheimer disease"" supported by the sentence: ""Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.""?",False, -26276598,Ampicillin related to Sepsis,250,Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.,"Is the triple ""Ampicillin related to Sepsis"" supported by the sentence: ""Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.""?",False, -19644222,Ampicillin related to pneumonia,251,"This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.","Is the triple ""Ampicillin related to pneumonia"" supported by the sentence: ""This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.""?",False, -27702232,Ampicillin causes Sepsis,252,Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.,"Is the triple ""Ampicillin causes Sepsis"" supported by the sentence: ""Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.""?",False, -15854005,Ampicillin causes pneumonia,253,"Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.","Is the triple ""Ampicillin causes pneumonia"" supported by the sentence: ""Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.""?",False, -14938843,Ampicillin affects Sepsis,254,"No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.","Is the triple ""Ampicillin affects Sepsis"" supported by the sentence: ""No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.""?",False, -8930713,Ampicillin affects gonorrhea,255,A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.,"Is the triple ""Ampicillin affects gonorrhea"" supported by the sentence: ""A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.""?",False, -21012437,Ampicillin disrupts gonorrhea,256,"Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.","Is the triple ""Ampicillin disrupts gonorrhea"" supported by the sentence: ""Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.""?",False, -24823382,Ampicillin prevents Infection,257,"Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.","Is the triple ""Ampicillin prevents Infection"" supported by the sentence: ""Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.""?",False, -22838487,Ampicillin prevents chorioamnionitis,258,OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.,"Is the triple ""Ampicillin prevents chorioamnionitis"" supported by the sentence: ""OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.""?",False, -18801502,Ampicillin prevents Sepsis,259,"JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.","Is the triple ""Ampicillin prevents Sepsis"" supported by the sentence: ""JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.""?",False, -17465667,Ampicillin prevents pneumonia,260,"Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).","Is the triple ""Ampicillin prevents pneumonia"" supported by the sentence: ""Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).""?",False, -13675414,Ampicillin predisposes Sepsis,261,Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.,"Is the triple ""Ampicillin predisposes Sepsis"" supported by the sentence: ""Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.""?",False, -26048573,Carbenicillin causes bacterial infectious disease,262,"Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.","Is the triple ""Carbenicillin causes bacterial infectious disease"" supported by the sentence: ""Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.""?",False, -19319362,Benzoyl Peroxide related to acne,263,"Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.","Is the triple ""Benzoyl Peroxide related to acne"" supported by the sentence: ""Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.""?",False, -10427135,Benzoyl Peroxide affects acne,264,The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).,"Is the triple ""Benzoyl Peroxide affects acne"" supported by the sentence: ""The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).""?",False, -7769964,Benzoyl Peroxide disrupts acne,265,We used benzoyl peroxide to bring about rapid suppression of P acnes.,"Is the triple ""Benzoyl Peroxide disrupts acne"" supported by the sentence: ""We used benzoyl peroxide to bring about rapid suppression of P acnes.""?",False, -12531968,Benzoyl Peroxide prevents acne,266,"Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.","Is the triple ""Benzoyl Peroxide prevents acne"" supported by the sentence: ""Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.""?",False, -11597597,Proglumide related to peptic ulcer disease,267,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Proglumide related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, -18195146,Pirenzepine causes peptic ulcer disease,268,Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.,"Is the triple ""Pirenzepine causes peptic ulcer disease"" supported by the sentence: ""Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.""?",False, -13022427,Pirenzepine affects gastroesophageal reflux disease,269,"However, the effect of pirenzepine on GERD remains to be defined.","Is the triple ""Pirenzepine affects gastroesophageal reflux disease"" supported by the sentence: ""However, the effect of pirenzepine on GERD remains to be defined.""?",False, -18547780,Pirenzepine prevents peptic ulcer disease,270,Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.,"Is the triple ""Pirenzepine prevents peptic ulcer disease"" supported by the sentence: ""Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.""?",False, -9345084,Magnesium Oxide related to constipation disorder,271,"In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.","Is the triple ""Magnesium Oxide related to constipation disorder"" supported by the sentence: ""In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.""?",False, -19628284,Magnesium Oxide disrupts constipation disorder,272,"However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.","Is the triple ""Magnesium Oxide disrupts constipation disorder"" supported by the sentence: ""However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.""?",False, -25714783,Ticarcillin prevents Sepsis,273,A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.,"Is the triple ""Ticarcillin prevents Sepsis"" supported by the sentence: ""A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.""?",False, -24735602,Urea related to hepatocellular carcinoma,274,"Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.","Is the triple ""Urea related to hepatocellular carcinoma"" supported by the sentence: ""Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.""?",False, -18901918,Urea related to radiodermatitis,275,AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.,"Is the triple ""Urea related to radiodermatitis"" supported by the sentence: ""AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.""?",False, -16423422,Urea related to skin disorder,276,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to skin disorder"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, -16423421,Urea related to psoriasis,277,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to psoriasis"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, -10983160,"Urea related to dermatitis, atopic",278,[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].,"Is the triple ""Urea related to dermatitis, atopic"" supported by the sentence: ""[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].""?",False, -9883467,Urea related to diabetes mellitus,279,"Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.","Is the triple ""Urea related to diabetes mellitus"" supported by the sentence: ""Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.""?",False, -9435238,Urea related to type 2 diabetes mellitus,280,"Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.","Is the triple ""Urea related to type 2 diabetes mellitus"" supported by the sentence: ""Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.""?",False, -7778173,Urea related to ornithine carbamoyltransferase deficiency,281,We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).,"Is the triple ""Urea related to ornithine carbamoyltransferase deficiency"" supported by the sentence: ""We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).""?",False, -17162115,Urea causes diabetes mellitus,282,"Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.","Is the triple ""Urea causes diabetes mellitus"" supported by the sentence: ""Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.""?",False, -16469778,Urea causes type 2 diabetes mellitus,283,"To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.","Is the triple ""Urea causes type 2 diabetes mellitus"" supported by the sentence: ""To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.""?",False, -18510405,Urea affects hepatocellular carcinoma,284,[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].,"Is the triple ""Urea affects hepatocellular carcinoma"" supported by the sentence: ""[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].""?",False, -10531949,Urea affects diabetes mellitus,285,[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].,"Is the triple ""Urea affects diabetes mellitus"" supported by the sentence: ""[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].""?",False, -8735554,Urea affects type 2 diabetes mellitus,286,Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.,"Is the triple ""Urea affects type 2 diabetes mellitus"" supported by the sentence: ""Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.""?",False, -25972859,Urea produces citrullinemia,287,Citrullinemia with defective urea production.,"Is the triple ""Urea produces citrullinemia"" supported by the sentence: ""Citrullinemia with defective urea production.""?",False, -18901919,Urea prevents radiodermatitis,288,This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.,"Is the triple ""Urea prevents radiodermatitis"" supported by the sentence: ""This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.""?",False, -15303897,Urea prevents Palmar-plantar erythrodysesthesia syndrome,289,This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.,"Is the triple ""Urea prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.""?",False, -19154964,Urea predisposes type 2 diabetes mellitus,290,"A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.","Is the triple ""Urea predisposes type 2 diabetes mellitus"" supported by the sentence: ""A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.""?",False, -21175471,Mannitol related to intracranial hypertension,291,"To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.","Is the triple ""Mannitol related to intracranial hypertension"" supported by the sentence: ""To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.""?",False, -17706176,Mannitol related to acute kidney failure,292,"Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.","Is the triple ""Mannitol related to acute kidney failure"" supported by the sentence: ""Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.""?",False, -17429747,Mannitol related to stroke disorder,293,The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.,"Is the triple ""Mannitol related to stroke disorder"" supported by the sentence: ""The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.""?",False, -15130853,Mannitol related to brain cancer,294,"In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.","Is the triple ""Mannitol related to brain cancer"" supported by the sentence: ""In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.""?",False, -13201402,Mannitol related to cystic fibrosis,295,Inhaled mannitol in cystic fibrosis.,"Is the triple ""Mannitol related to cystic fibrosis"" supported by the sentence: ""Inhaled mannitol in cystic fibrosis.""?",False, -12470912,Mannitol related to brain edema,296,"The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.","Is the triple ""Mannitol related to brain edema"" supported by the sentence: ""The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.""?",False, -11875924,Mannitol related to ciguatera fish poisoning,297,"The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.","Is the triple ""Mannitol related to ciguatera fish poisoning"" supported by the sentence: ""The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.""?",False, -10780851,Mannitol related to brain injury,298,Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.,"Is the triple ""Mannitol related to brain injury"" supported by the sentence: ""Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.""?",False, -8946483,Mannitol related to bronchiectasis,299,"REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.","Is the triple ""Mannitol related to bronchiectasis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.""?",False, -7891128,Mannitol related to injury,300,"The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.","Is the triple ""Mannitol related to injury"" supported by the sentence: ""The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.""?",False, -26278567,Mannitol causes brain cancer,301,Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.,"Is the triple ""Mannitol causes brain cancer"" supported by the sentence: ""Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.""?",False, -25099324,Mannitol causes hearing loss disorder,302,A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.,"Is the triple ""Mannitol causes hearing loss disorder"" supported by the sentence: ""A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.""?",False, -21259902,Mannitol causes brain injury,303,"In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.","Is the triple ""Mannitol causes brain injury"" supported by the sentence: ""In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.""?",False, -18351985,Mannitol causes hypotensive disorder,304,"All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.","Is the triple ""Mannitol causes hypotensive disorder"" supported by the sentence: ""All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.""?",False, -15545947,Mannitol causes brain edema,305,"This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.","Is the triple ""Mannitol causes brain edema"" supported by the sentence: ""This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.""?",False, -12105301,Mannitol causes intracranial hypertension,306,"There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.","Is the triple ""Mannitol causes intracranial hypertension"" supported by the sentence: ""There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.""?",False, -11383337,Mannitol causes injury,307,DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.,"Is the triple ""Mannitol causes injury"" supported by the sentence: ""DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.""?",False, -9825580,Mannitol causes acute kidney failure,308,"In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.","Is the triple ""Mannitol causes acute kidney failure"" supported by the sentence: ""In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.""?",False, -22439282,Mannitol affects acute kidney failure,309,Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.,"Is the triple ""Mannitol affects acute kidney failure"" supported by the sentence: ""Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.""?",False, -18431992,Mannitol affects hypotensive disorder,310,It is unknown if mannitol is a contributing factor in the observed hypotension.,"Is the triple ""Mannitol affects hypotensive disorder"" supported by the sentence: ""It is unknown if mannitol is a contributing factor in the observed hypotension.""?",False, -10780860,Mannitol affects brain injury,311,"Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.","Is the triple ""Mannitol affects brain injury"" supported by the sentence: ""Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.""?",False, -10701562,Mannitol affects injury,312,THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.,"Is the triple ""Mannitol affects injury"" supported by the sentence: ""THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.""?",False, -10686125,"Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive",313,"EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.","Is the triple ""Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.""?",False, -9315186,Mannitol affects intracranial hypertension,314,"OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.","Is the triple ""Mannitol affects intracranial hypertension"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.""?",False, -7084537,Mannitol affects brain edema,315,The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.,"Is the triple ""Mannitol affects brain edema"" supported by the sentence: ""The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.""?",False, -27493988,Mannitol disrupts injury,316,"We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.","Is the triple ""Mannitol disrupts injury"" supported by the sentence: ""We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.""?",False, -26052295,Mannitol disrupts brain edema,317,Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.,"Is the triple ""Mannitol disrupts brain edema"" supported by the sentence: ""Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.""?",False, -18331127,Mannitol prevents Pain,318,"Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.","Is the triple ""Mannitol prevents Pain"" supported by the sentence: ""Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.""?",False, -17838550,Mannitol prevents brain injury,319,"Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.","Is the triple ""Mannitol prevents brain injury"" supported by the sentence: ""Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.""?",False, -9550870,Mannitol prevents acute kidney failure,320,"However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.","Is the triple ""Mannitol prevents acute kidney failure"" supported by the sentence: ""However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.""?",False, -8530867,Mannitol prevents brain edema,321,BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.,"Is the triple ""Mannitol prevents brain edema"" supported by the sentence: ""BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.""?",False, -7816754,Mannitol prevents intracranial hypertension,322,"For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.","Is the triple ""Mannitol prevents intracranial hypertension"" supported by the sentence: ""For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.""?",False, -21038220,Mannitol exacerbates intracranial hypertension,323,Does a bolus of mannitol initially aggravate intracranial hypertension?,"Is the triple ""Mannitol exacerbates intracranial hypertension"" supported by the sentence: ""Does a bolus of mannitol initially aggravate intracranial hypertension?""?",False, -23554906,Mannitol predisposes brain injury,324,"This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.","Is the triple ""Mannitol predisposes brain injury"" supported by the sentence: ""This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.""?",False, -23171283,Mannitol predisposes acute kidney failure,325,"In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).","Is the triple ""Mannitol predisposes acute kidney failure"" supported by the sentence: ""In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).""?",False, -15337034,Mannitol predisposes brain edema,326,D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.,"Is the triple ""Mannitol predisposes brain edema"" supported by the sentence: ""D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.""?",False, -9368450,Mannitol predisposes injury,327,"Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.","Is the triple ""Mannitol predisposes injury"" supported by the sentence: ""Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.""?",False, -25560945,Artesunic acid affects neoplasm,328,Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.""?",False, -20380317,Artesunic acid affects neoplasm,329,Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.""?",False, -17022154,Artesunic acid affects cytomegalovirus infection,330,"OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.","Is the triple ""Artesunic acid affects cytomegalovirus infection"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.""?",False, -15447136,Artesunic acid affects malaria,331,BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.,"Is the triple ""Artesunic acid affects malaria"" supported by the sentence: ""BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.""?",False, -14695052,Artesunic acid affects Fever,332,"In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.","Is the triple ""Artesunic acid affects Fever"" supported by the sentence: ""In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.""?",False, -9350747,Artesunic acid affects Plasmodium falciparum malaria,333,The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.,"Is the triple ""Artesunic acid affects Plasmodium falciparum malaria"" supported by the sentence: ""The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.""?",False, -19053159,Artesunic acid disrupts Plasmodium falciparum malaria,334,"BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.","Is the triple ""Artesunic acid disrupts Plasmodium falciparum malaria"" supported by the sentence: ""BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.""?",False, -17269195,Artesunic acid disrupts neoplasm,335,The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.,"Is the triple ""Artesunic acid disrupts neoplasm"" supported by the sentence: ""The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.""?",False, -16806460,Artesunic acid disrupts malaria,336,"CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.","Is the triple ""Artesunic acid disrupts malaria"" supported by the sentence: ""CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.""?",False, -10013375,Artesunic acid prevents schistosomiasis,337,CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.,"Is the triple ""Artesunic acid prevents schistosomiasis"" supported by the sentence: ""CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.""?",False, -8540473,Artesunic acid prevents malaria,338,"INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.","Is the triple ""Artesunic acid prevents malaria"" supported by the sentence: ""INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.""?",False, -16567243,Artesunic acid predisposes malaria,339,"We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.","Is the triple ""Artesunic acid predisposes malaria"" supported by the sentence: ""We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.""?",False, -27639365,Artemether affects Fever,340,RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.,"Is the triple ""Artemether affects Fever"" supported by the sentence: ""RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.""?",False, -25565511,Artemether affects malaria,341,Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.,"Is the triple ""Artemether affects malaria"" supported by the sentence: ""Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.""?",False, -19253720,Artemether prevents malaria,342,New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.,"Is the triple ""Artemether prevents malaria"" supported by the sentence: ""New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.""?",False, -10002115,Artemether prevents urinary schistosomiasis,343,"Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.","Is the triple ""Artemether prevents urinary schistosomiasis"" supported by the sentence: ""Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.""?",False, -8716445,Isoproterenol causes atrial fibrillation,344,"A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).","Is the triple ""Isoproterenol causes atrial fibrillation"" supported by the sentence: ""A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).""?",False, -25912644,Isoproterenol affects obstructive lung disease,345,The effect of isoproterenol on airway obstruction in cystic fibrosis.,"Is the triple ""Isoproterenol affects obstructive lung disease"" supported by the sentence: ""The effect of isoproterenol on airway obstruction in cystic fibrosis.""?",False, -24900253,Isoproterenol affects obesity disorder,346,"OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.","Is the triple ""Isoproterenol affects obesity disorder"" supported by the sentence: ""OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.""?",False, -9298156,Isoproterenol affects atrial fibrillation,347,[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].,"Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].""?",False, -7542857,Isoproterenol affects atrial fibrillation,348,"OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.","Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.""?",False, -26721271,Isoproterenol disrupts obesity disorder,349,"In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.","Is the triple ""Isoproterenol disrupts obesity disorder"" supported by the sentence: ""In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.""?",False, -7635739,Isoproterenol predisposes atrial fibrillation,350,The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.,"Is the triple ""Isoproterenol predisposes atrial fibrillation"" supported by the sentence: ""The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.""?",False, -23874783,Bacitracin A related to pneumonia,351,"These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .","Is the triple ""Bacitracin A related to pneumonia"" supported by the sentence: ""These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .""?",False, -26428368,Bacitracin A prevents bacterial infectious disease,352,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Bacitracin A prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, -18829774,Bacitracin A prevents cardiac rhythm disease,353,"The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.","Is the triple ""Bacitracin A prevents cardiac rhythm disease"" supported by the sentence: ""The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.""?",False, -16650012,Diflunisal subclass of Diflunisal glucuronide ester,354,"We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.","Is the triple ""Diflunisal subclass of Diflunisal glucuronide ester"" supported by the sentence: ""We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.""?",False, -26133976,Diflunisal causes Pain,355,"Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).","Is the triple ""Diflunisal causes Pain"" supported by the sentence: ""Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).""?",False, -26132411,Diflunisal affects Pain,356,[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].,"Is the triple ""Diflunisal affects Pain"" supported by the sentence: ""[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].""?",False, -26009871,Diflunisal affects Fever,357,"In contrast, submaximal fever in rabbits was not reduced by diflunisal.","Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""In contrast, submaximal fever in rabbits was not reduced by diflunisal.""?",False, -26009870,Diflunisal affects Fever,358,Effects of diflunisal on fever in the rabbit and the rat.,"Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""Effects of diflunisal on fever in the rabbit and the rat.""?",False, -13234484,Diflunisal affects Diflunisal glucuronide ester,359,"Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.","Is the triple ""Diflunisal affects Diflunisal glucuronide ester"" supported by the sentence: ""Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.""?",False, -14757294,Diflunisal prevents Pain,360,"It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.","Is the triple ""Diflunisal prevents Pain"" supported by the sentence: ""It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.""?",False, -17020332,Salsalate causes Insulin resistance,361,"Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.","Is the triple ""Salsalate causes Insulin resistance"" supported by the sentence: ""Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.""?",False, -21902985,Salsalate affects diabetes mellitus,362,Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.,"Is the triple ""Salsalate affects diabetes mellitus"" supported by the sentence: ""Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.""?",False, -25541729,Salsalate disrupts Insulin resistance,363,Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.,"Is the triple ""Salsalate disrupts Insulin resistance"" supported by the sentence: ""Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.""?",False, -19533984,Salsalate prevents diabetes mellitus,364,"Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.","Is the triple ""Salsalate prevents diabetes mellitus"" supported by the sentence: ""Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.""?",False, -26431050,Sodium salicylate causes Fever,365,"Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.","Is the triple ""Sodium salicylate causes Fever"" supported by the sentence: ""Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.""?",False, -11882723,Sodium salicylate affects Fever,366,A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.""?",False, -9968696,Sodium salicylate affects Fever,367,The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).""?",False, -15893532,Sodium salicylate predisposes Pain,368,Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.,"Is the triple ""Sodium salicylate predisposes Pain"" supported by the sentence: ""Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.""?",False, -7201382,Aspirin subclass of Salicylic Acid,369,"The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.","Is the triple ""Aspirin subclass of Salicylic Acid"" supported by the sentence: ""The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.""?",False, -26818861,Aspirin related to myocardial infarction,370,Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.,"Is the triple ""Aspirin related to myocardial infarction"" supported by the sentence: ""Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.""?",False, -26532873,Aspirin related to classic familial adenomatous polyposis,371,The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.,"Is the triple ""Aspirin related to classic familial adenomatous polyposis"" supported by the sentence: ""The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.""?",False, -26329928,Aspirin related to type 2 diabetes mellitus,372,Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.,"Is the triple ""Aspirin related to type 2 diabetes mellitus"" supported by the sentence: ""Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.""?",False, -26168722,Aspirin related to Inflammation,373,"The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.","Is the triple ""Aspirin related to Inflammation"" supported by the sentence: ""The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.""?",False, -24076103,Aspirin related to Hemorrhage,374,"Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.","Is the triple ""Aspirin related to Hemorrhage"" supported by the sentence: ""Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.""?",False, -20241570,Aspirin related to Pain,375,Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.,"Is the triple ""Aspirin related to Pain"" supported by the sentence: ""Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.""?",False, -18524506,Aspirin related to cataract,376,Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.,"Is the triple ""Aspirin related to cataract"" supported by the sentence: ""Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.""?",False, -18008074,Aspirin related to diabetes mellitus,377,"It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).","Is the triple ""Aspirin related to diabetes mellitus"" supported by the sentence: ""It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).""?",False, -17483160,Aspirin related to mucocutaneous lymph node syndrome,378,We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.,"Is the triple ""Aspirin related to mucocutaneous lymph node syndrome"" supported by the sentence: ""We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.""?",False, -16078277,Aspirin related to preeclampsia,379,Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.,"Is the triple ""Aspirin related to preeclampsia"" supported by the sentence: ""Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.""?",False, -15283505,Aspirin related to thrombotic disease,380,"The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.","Is the triple ""Aspirin related to thrombotic disease"" supported by the sentence: ""The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.""?",False, -13829413,Aspirin related to retinal vein occlusion,381,Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.,"Is the triple ""Aspirin related to retinal vein occlusion"" supported by the sentence: ""Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.""?",False, -13174915,Aspirin related to ST-elevation myocardial infarction,382,"The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.","Is the triple ""Aspirin related to ST-elevation myocardial infarction"" supported by the sentence: ""The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.""?",False, -12865539,Aspirin related to cardiovascular disorder,383,"METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.","Is the triple ""Aspirin related to cardiovascular disorder"" supported by the sentence: ""METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.""?",False, -12749655,Aspirin related to Salicylic Acid,384,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, -12502970,Aspirin related to coronary artery disorder,385,Low-dose aspirin and heparin in unstable coronary artery disease.,"Is the triple ""Aspirin related to coronary artery disorder"" supported by the sentence: ""Low-dose aspirin and heparin in unstable coronary artery disease.""?",False, -10635434,Aspirin related to rheumatic heart disease,386,A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.,"Is the triple ""Aspirin related to rheumatic heart disease"" supported by the sentence: ""A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.""?",False, -10534181,Aspirin related to osteoarthritis,387,"A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.","Is the triple ""Aspirin related to osteoarthritis"" supported by the sentence: ""A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.""?",False, -10473195,Aspirin related to asthma,388,"Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.","Is the triple ""Aspirin related to asthma"" supported by the sentence: ""Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.""?",False, -9315521,Aspirin related to atrial fibrillation,389,"In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.","Is the triple ""Aspirin related to atrial fibrillation"" supported by the sentence: ""In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.""?",False, -8718389,Aspirin related to stroke disorder,390,Heparin and aspirin in stroke.,"Is the triple ""Aspirin related to stroke disorder"" supported by the sentence: ""Heparin and aspirin in stroke.""?",False, -8430499,Aspirin related to Ischemic stroke,391,Heparin versus aspirin in ischaemic stroke.,"Is the triple ""Aspirin related to Ischemic stroke"" supported by the sentence: ""Heparin versus aspirin in ischaemic stroke.""?",False, -7718877,Aspirin related to acute coronary syndrome,392,"In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.","Is the triple ""Aspirin related to acute coronary syndrome"" supported by the sentence: ""In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.""?",False, -8745735,Aspirin related to Salicylic Acid,393,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, -12749656,Aspirin close match Salicylic Acid,394,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, -8745736,Aspirin close match Salicylic Acid,395,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, -10716638,Aspirin coexists with Salicylic Acid,396,An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.,"Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.""?",False, -10182446,Aspirin coexists with Salicylic Acid,397,"A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.","Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.""?",False, -8959647,Aspirin derives from Salicylic Acid,398,Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.,"Is the triple ""Aspirin derives from Salicylic Acid"" supported by the sentence: ""Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.""?",False, -7421635,Aspirin physically interacts with Salicylic Acid,399,"Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.""?",False, -9047883,Aspirin physically interacts with Salicylic Acid,400,"Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.""?",False, -27550629,Aspirin causes transient ischemic attack,401,"In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).","Is the triple ""Aspirin causes transient ischemic attack"" supported by the sentence: ""In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).""?",False, -27093984,Aspirin causes Sepsis,402,Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).,"Is the triple ""Aspirin causes Sepsis"" supported by the sentence: ""Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).""?",False, -26941889,Aspirin causes colonic neoplasm,403,"Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.","Is the triple ""Aspirin causes colonic neoplasm"" supported by the sentence: ""Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.""?",False, -26621273,Aspirin causes diabetic retinopathy,404,"Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.","Is the triple ""Aspirin causes diabetic retinopathy"" supported by the sentence: ""Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.""?",False, -25682183,Aspirin causes Toothache,405,The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.,"Is the triple ""Aspirin causes Toothache"" supported by the sentence: ""The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.""?",False, -24276147,Aspirin causes osteoarthritis,406,"The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.","Is the triple ""Aspirin causes osteoarthritis"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.""?",False, -23603605,Aspirin causes infertility disorder,407,"Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.","Is the triple ""Aspirin causes infertility disorder"" supported by the sentence: ""Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.""?",False, -22149437,Aspirin causes myocardial infarction,408,"In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.","Is the triple ""Aspirin causes myocardial infarction"" supported by the sentence: ""In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.""?",False, -21269587,Aspirin causes preeclampsia,409,This review article will contribute to the in-depth understanding of LDA-induced PE prevention.,"Is the triple ""Aspirin causes preeclampsia"" supported by the sentence: ""This review article will contribute to the in-depth understanding of LDA-induced PE prevention.""?",False, -21190178,Aspirin causes Varicose Ulcer,410,Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.,"Is the triple ""Aspirin causes Varicose Ulcer"" supported by the sentence: ""Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.""?",False, -20967677,Aspirin causes cerebral infarction,411,"The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.","Is the triple ""Aspirin causes cerebral infarction"" supported by the sentence: ""The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.""?",False, -20453125,Aspirin causes squamous cell carcinoma,412,"Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.","Is the triple ""Aspirin causes squamous cell carcinoma"" supported by the sentence: ""Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.""?",False, -20257764,Aspirin causes vascular disorder,413,Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.,"Is the triple ""Aspirin causes vascular disorder"" supported by the sentence: ""Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.""?",False, -18467493,Aspirin causes periodontitis,414,Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.,"Is the triple ""Aspirin causes periodontitis"" supported by the sentence: ""Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.""?",False, -18133593,Aspirin causes acute lung injury,415,Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.,"Is the triple ""Aspirin causes acute lung injury"" supported by the sentence: ""Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.""?",False, -17905974,Aspirin causes mucocutaneous lymph node syndrome,416,Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.,"Is the triple ""Aspirin causes mucocutaneous lymph node syndrome"" supported by the sentence: ""Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.""?",False, -16266546,Aspirin causes cardiovascular disorder,417,BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.,"Is the triple ""Aspirin causes cardiovascular disorder"" supported by the sentence: ""BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.""?",False, -15908394,Aspirin causes arthritic joint disease,418,Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.,"Is the triple ""Aspirin causes arthritic joint disease"" supported by the sentence: ""Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.""?",False, -15782733,Aspirin causes ulcerative colitis,419,Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.,"Is the triple ""Aspirin causes ulcerative colitis"" supported by the sentence: ""Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.""?",False, -15251529,Aspirin causes myocardial ischemia,420,Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.,"Is the triple ""Aspirin causes myocardial ischemia"" supported by the sentence: ""Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.""?",False, -15022291,Aspirin causes pneumonia,421,"BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.","Is the triple ""Aspirin causes pneumonia"" supported by the sentence: ""BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.""?",False, -14953515,Aspirin causes diabetes mellitus,422,"Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.","Is the triple ""Aspirin causes diabetes mellitus"" supported by the sentence: ""Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.""?",False, -14693157,Aspirin causes atrial fibrillation,423,"I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.","Is the triple ""Aspirin causes atrial fibrillation"" supported by the sentence: ""I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.""?",False, -14660024,Aspirin causes ischemic disease,424,C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.,"Is the triple ""Aspirin causes ischemic disease"" supported by the sentence: ""C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.""?",False, -14296178,Aspirin causes type 2 diabetes mellitus,425,Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.,"Is the triple ""Aspirin causes type 2 diabetes mellitus"" supported by the sentence: ""Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.""?",False, -13914591,Aspirin causes digestive system disorder,426,"Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.","Is the triple ""Aspirin causes digestive system disorder"" supported by the sentence: ""Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.""?",False, -13814866,Aspirin causes Fever,427,Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.,"Is the triple ""Aspirin causes Fever"" supported by the sentence: ""Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.""?",False, -13639281,Aspirin causes acute coronary syndrome,428,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes acute coronary syndrome"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, -13639280,Aspirin causes Ischemic stroke,429,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes Ischemic stroke"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, -13405854,Aspirin causes hypertensive disorder,430,"The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.","Is the triple ""Aspirin causes hypertensive disorder"" supported by the sentence: ""The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.""?",False, -13278968,Aspirin causes adult acute respiratory distress syndrome,431,Aspirin-induced non-cardiogenic pulmonary edema.,"Is the triple ""Aspirin causes adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin-induced non-cardiogenic pulmonary edema.""?",False, -11251562,Aspirin causes Pain,432,The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).,"Is the triple ""Aspirin causes Pain"" supported by the sentence: ""The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).""?",False, -10850020,Aspirin causes migraine disorder,433,"When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.","Is the triple ""Aspirin causes migraine disorder"" supported by the sentence: ""When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.""?",False, -10555051,Aspirin causes duodenal ulcer,434,"As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.","Is the triple ""Aspirin causes duodenal ulcer"" supported by the sentence: ""As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.""?",False, -9350599,Aspirin causes active peptic ulcer disease,435,DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.,"Is the triple ""Aspirin causes active peptic ulcer disease"" supported by the sentence: ""DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.""?",False, -9238263,Aspirin causes blood coagulation disease,436,"An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.","Is the triple ""Aspirin causes blood coagulation disease"" supported by the sentence: ""An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.""?",False, -8683872,Aspirin causes stroke disorder,437,"MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.","Is the triple ""Aspirin causes stroke disorder"" supported by the sentence: ""MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.""?",False, -8518235,Aspirin causes peptic ulcer disease,438,Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.,"Is the triple ""Aspirin causes peptic ulcer disease"" supported by the sentence: ""Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.""?",False, -8466167,Aspirin causes Headache,439,(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.,"Is the triple ""Aspirin causes Headache"" supported by the sentence: ""(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.""?",False, -8232293,Aspirin causes Hemorrhage,440,"The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.","Is the triple ""Aspirin causes Hemorrhage"" supported by the sentence: ""The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.""?",False, -7594346,Aspirin causes asthma,441,LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.,"Is the triple ""Aspirin causes asthma"" supported by the sentence: ""LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.""?",False, -7353622,Aspirin causes gastric ulcer,442,BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.,"Is the triple ""Aspirin causes gastric ulcer"" supported by the sentence: ""BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.""?",False, -7227553,Aspirin causes injury,443,"Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.","Is the triple ""Aspirin causes injury"" supported by the sentence: ""Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.""?",False, -26773149,Aspirin affects atrial fibrillation,444,Further studies are needed to clarify the role of aspirin in atrial fibrillation.,"Is the triple ""Aspirin affects atrial fibrillation"" supported by the sentence: ""Further studies are needed to clarify the role of aspirin in atrial fibrillation.""?",False, -26425353,Aspirin affects atherosclerosis,445,Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.""?",False, -26396469,Aspirin affects Dysmenorrhea,446,The effect of aspirin on dysmenorrhea in adolescents.,"Is the triple ""Aspirin affects Dysmenorrhea"" supported by the sentence: ""The effect of aspirin on dysmenorrhea in adolescents.""?",False, -25760183,Aspirin affects thrombophilia due to thrombin defect,447,Effect of aspirin on postoperative venous thrombosis.,"Is the triple ""Aspirin affects thrombophilia due to thrombin defect"" supported by the sentence: ""Effect of aspirin on postoperative venous thrombosis.""?",False, -24559876,Aspirin affects coronary artery disorder,448,"CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.","Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.""?",False, -23119254,Aspirin affects brain aneurysm,449,Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.""?",False, -21758599,Aspirin affects brain aneurysm,450,CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.""?",False, -21116359,Aspirin affects major depressive disorder,451,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, -21116358,Aspirin affects schizophrenia,452,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects schizophrenia"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, -21031382,Aspirin affects neoplasm,453,"Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.""?",False, -20857373,Aspirin affects melanoma,454,"It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.","Is the triple ""Aspirin affects melanoma"" supported by the sentence: ""It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.""?",False, -20741170,Aspirin affects fetal growth restriction,455,Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.,"Is the triple ""Aspirin affects fetal growth restriction"" supported by the sentence: ""Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.""?",False, -20453126,Aspirin affects squamous cell carcinoma,456,"To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.","Is the triple ""Aspirin affects squamous cell carcinoma"" supported by the sentence: ""To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.""?",False, -19190473,Aspirin affects acute lung injury,457,RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.,"Is the triple ""Aspirin affects acute lung injury"" supported by the sentence: ""RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.""?",False, -18874269,Aspirin affects preeclampsia,458,Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.,"Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.""?",False, -18830463,Aspirin affects Varicose Ulcer,459,"To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.","Is the triple ""Aspirin affects Varicose Ulcer"" supported by the sentence: ""To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.""?",False, -18706529,Aspirin affects mucocutaneous lymph node syndrome,460,"Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.","Is the triple ""Aspirin affects mucocutaneous lymph node syndrome"" supported by the sentence: ""Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.""?",False, -18617993,Aspirin affects Sepsis,461,"This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.","Is the triple ""Aspirin affects Sepsis"" supported by the sentence: ""This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.""?",False, -18348076,Aspirin affects Headache,462,"We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).","Is the triple ""Aspirin affects Headache"" supported by the sentence: ""We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).""?",False, -18344374,Aspirin affects bone fracture,463,This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.,"Is the triple ""Aspirin affects bone fracture"" supported by the sentence: ""This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.""?",False, -18277701,Aspirin affects adult acute respiratory distress syndrome,464,"Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.","Is the triple ""Aspirin affects adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.""?",False, -18092588,Aspirin affects Fever,465,"Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.""?",False, -17810437,Aspirin affects migraine disorder,466,"Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.","Is the triple ""Aspirin affects migraine disorder"" supported by the sentence: ""Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.""?",False, -16655533,Aspirin affects stroke disorder,467,Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.""?",False, -16466986,Aspirin affects myocardial ischemia,468,Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).""?",False, -16123563,Aspirin affects digestive system disorder,469,[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].,"Is the triple ""Aspirin affects digestive system disorder"" supported by the sentence: ""[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].""?",False, -15829936,Aspirin affects hypertriglyceridemia,470,Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.,"Is the triple ""Aspirin affects hypertriglyceridemia"" supported by the sentence: ""Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.""?",False, -15667690,Aspirin affects hepatocellular carcinoma,471,Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.,"Is the triple ""Aspirin affects hepatocellular carcinoma"" supported by the sentence: ""Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.""?",False, -15311732,Aspirin affects periodontitis,472,"METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.","Is the triple ""Aspirin affects periodontitis"" supported by the sentence: ""METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.""?",False, -15094783,Aspirin affects diabetic retinopathy,473,Effects of aspirin treatment on diabetic retinopathy.,"Is the triple ""Aspirin affects diabetic retinopathy"" supported by the sentence: ""Effects of aspirin treatment on diabetic retinopathy.""?",False, -13831910,Aspirin affects gastric ulcer,474,The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.,"Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.""?",False, -13734334,Aspirin affects Pregnancy,475,"There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.","Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.""?",False, -13647977,Aspirin affects neoplasm,476,"We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.""?",False, -13624111,Aspirin affects pneumonia,477,OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.,"Is the triple ""Aspirin affects pneumonia"" supported by the sentence: ""OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.""?",False, -13559011,Aspirin affects type 2 diabetes mellitus,478,"Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.","Is the triple ""Aspirin affects type 2 diabetes mellitus"" supported by the sentence: ""Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.""?",False, -13493823,Aspirin affects thrombotic disease,479,Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.,"Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.""?",False, -12884495,Aspirin affects duodenal ulcer,480,"Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.","Is the triple ""Aspirin affects duodenal ulcer"" supported by the sentence: ""Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.""?",False, -12815469,Aspirin affects atherosclerosis,481,Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.""?",False, -12769418,Aspirin affects active peptic ulcer disease,482,The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.""?",False, -12607959,Aspirin affects plasma cell myeloma,483,Does low-dose aspirin have antineoplastic effects in multiple myeloma?,"Is the triple ""Aspirin affects plasma cell myeloma"" supported by the sentence: ""Does low-dose aspirin have antineoplastic effects in multiple myeloma?""?",False, -12446363,Aspirin affects hypertensive disorder,484,Diabetes mellitus and hypertension are relative risk factors of AR and ASR.,"Is the triple ""Aspirin affects hypertensive disorder"" supported by the sentence: ""Diabetes mellitus and hypertension are relative risk factors of AR and ASR.""?",False, -12124867,Aspirin affects heart disorder,485,Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.,"Is the triple ""Aspirin affects heart disorder"" supported by the sentence: ""Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.""?",False, -11661767,Aspirin affects peptic ulcer disease,486,"CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.""?",False, -11474111,Aspirin affects diabetes mellitus,487,We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.,"Is the triple ""Aspirin affects diabetes mellitus"" supported by the sentence: ""We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.""?",False, -11357781,Aspirin affects ischemic disease,488,Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.,"Is the triple ""Aspirin affects ischemic disease"" supported by the sentence: ""Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.""?",False, -11341534,Aspirin affects ulcer disease,489,"Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.""?",False, -11135514,Aspirin affects cerebrovascular disorder,490,Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.,"Is the triple ""Aspirin affects cerebrovascular disorder"" supported by the sentence: ""Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.""?",False, -10875862,Aspirin affects acquired polycythemia vera,491,"Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.","Is the triple ""Aspirin affects acquired polycythemia vera"" supported by the sentence: ""Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.""?",False, -10830878,Aspirin affects Inflammation,492,"These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.""?",False, -10337669,Aspirin affects colorectal neoplasm,493,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Aspirin affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, -10331252,Aspirin affects peptic ulcer disease,494,"Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.""?",False, -10226347,Aspirin affects thrombophilia,495,"Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.","Is the triple ""Aspirin affects thrombophilia"" supported by the sentence: ""Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.""?",False, -10082315,Aspirin affects Pain,496,"Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.","Is the triple ""Aspirin affects Pain"" supported by the sentence: ""Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.""?",False, -10068618,Aspirin affects adenoma,497,CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.,"Is the triple ""Aspirin affects adenoma"" supported by the sentence: ""CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.""?",False, -9766251,Aspirin affects injury,498,Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.,"Is the triple ""Aspirin affects injury"" supported by the sentence: ""Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.""?",False, -9581221,Aspirin affects cataract,499,"Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.","Is the triple ""Aspirin affects cataract"" supported by the sentence: ""Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.""?",False, -9528323,Aspirin affects asthma,500,We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).,"Is the triple ""Aspirin affects asthma"" supported by the sentence: ""We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).""?",False, -9510044,Aspirin affects transient ischemic attack,501,This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.,"Is the triple ""Aspirin affects transient ischemic attack"" supported by the sentence: ""This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.""?",False, -9342553,Aspirin affects Salicylic Acid,502,"METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.""?",False, -9259288,Aspirin affects Fever,503,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, -9203900,Aspirin affects Hypercholesterolemia,504,This action of aspirin is blunted in hypercholesterolemia.,"Is the triple ""Aspirin affects Hypercholesterolemia"" supported by the sentence: ""This action of aspirin is blunted in hypercholesterolemia.""?",False, -9160463,Aspirin affects gastric ulcer,505,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.","Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.""?",False, -9084341,Aspirin affects Ischemic stroke,506,A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.,"Is the triple ""Aspirin affects Ischemic stroke"" supported by the sentence: ""A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.""?",False, -8650258,Aspirin affects Hemorrhage,507,"CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.""?",False, -8543326,Aspirin affects active peptic ulcer disease,508,OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.""?",False, -8290962,Aspirin affects ulcer disease,509,"Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.""?",False, -8187935,Aspirin affects injury,510,"Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.","Is the triple ""Aspirin affects injury"" supported by the sentence: ""Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.""?",False, -8173134,Aspirin affects thrombotic disease,511,"These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.","Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.""?",False, -8169760,Aspirin affects preeclampsia,512,"These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.","Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.""?",False, -7935107,Aspirin affects prostate cancer,513,"Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.","Is the triple ""Aspirin affects prostate cancer"" supported by the sentence: ""Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.""?",False, -7920712,Aspirin affects Hemorrhage,514,"After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.""?",False, -7876600,Aspirin affects Hemorrhage,515,"CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.""?",False, -7820545,Aspirin affects vascular disorder,516,The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.,"Is the triple ""Aspirin affects vascular disorder"" supported by the sentence: ""The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.""?",False, -7816175,Aspirin affects Pregnancy,517,L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.,"Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.""?",False, -7635677,Aspirin affects myocardial ischemia,518,We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.""?",False, -7478885,Aspirin affects coronary artery disorder,519,Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.,"Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.""?",False, -7468514,Aspirin affects stroke disorder,520,A metaregression analysis of the dose-response effect of aspirin on stroke.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""A metaregression analysis of the dose-response effect of aspirin on stroke.""?",False, -7251569,Aspirin affects myocardial infarction,521,A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.,"Is the triple ""Aspirin affects myocardial infarction"" supported by the sentence: ""A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.""?",False, -7213554,Aspirin affects cardiovascular disorder,522,"The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.","Is the triple ""Aspirin affects cardiovascular disorder"" supported by the sentence: ""The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.""?",False, -7156429,Aspirin affects Inflammation,523,"The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.""?",False, -14159165,Aspirin affects Salicylic Acid,524,"According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.""?",False, -27335099,Aspirin disrupts thrombophilia due to thrombin defect,525,"In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.","Is the triple ""Aspirin disrupts thrombophilia due to thrombin defect"" supported by the sentence: ""In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.""?",False, -24958273,Aspirin disrupts Fever,526,"In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.","Is the triple ""Aspirin disrupts Fever"" supported by the sentence: ""In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.""?",False, -24520178,Aspirin disrupts melanoma,527,"However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).","Is the triple ""Aspirin disrupts melanoma"" supported by the sentence: ""However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).""?",False, -24047967,Aspirin disrupts cardiovascular disorder,528,"Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.","Is the triple ""Aspirin disrupts cardiovascular disorder"" supported by the sentence: ""Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.""?",False, -22107293,Aspirin disrupts atrial fibrillation,529,Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.,"Is the triple ""Aspirin disrupts atrial fibrillation"" supported by the sentence: ""Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.""?",False, -22100738,Aspirin disrupts fetal growth restriction,530,"Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.","Is the triple ""Aspirin disrupts fetal growth restriction"" supported by the sentence: ""Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.""?",False, -22027792,Aspirin disrupts venous thromboembolism,531,Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.,"Is the triple ""Aspirin disrupts venous thromboembolism"" supported by the sentence: ""Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.""?",False, -21434441,Aspirin disrupts thrombophilia,532,"Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.","Is the triple ""Aspirin disrupts thrombophilia"" supported by the sentence: ""Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.""?",False, -20385507,Aspirin disrupts essential thrombocythemia,533,"However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.","Is the triple ""Aspirin disrupts essential thrombocythemia"" supported by the sentence: ""However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.""?",False, -19437129,Aspirin disrupts Sepsis,534,"This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).","Is the triple ""Aspirin disrupts Sepsis"" supported by the sentence: ""This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).""?",False, -19421638,Aspirin disrupts pneumonia,535,"CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.","Is the triple ""Aspirin disrupts pneumonia"" supported by the sentence: ""CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.""?",False, -19318532,Aspirin disrupts vascular disorder,536,These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.,"Is the triple ""Aspirin disrupts vascular disorder"" supported by the sentence: ""These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.""?",False, -18604728,Aspirin disrupts type 2 diabetes mellitus,537,"Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.","Is the triple ""Aspirin disrupts type 2 diabetes mellitus"" supported by the sentence: ""Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.""?",False, -18599969,Aspirin disrupts arthritic joint disease,538,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.","Is the triple ""Aspirin disrupts arthritic joint disease"" supported by the sentence: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?",False, -18445880,Aspirin disrupts ovarian cancer,539,"Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.","Is the triple ""Aspirin disrupts ovarian cancer"" supported by the sentence: ""Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.""?",False, -18225861,Aspirin disrupts Hemorrhage,540,"Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.","Is the triple ""Aspirin disrupts Hemorrhage"" supported by the sentence: ""Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.""?",False, -18203584,Aspirin disrupts brain aneurysm,541,Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.,"Is the triple ""Aspirin disrupts brain aneurysm"" supported by the sentence: ""Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.""?",False, -17476286,Aspirin disrupts Fatigue,542,"In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.","Is the triple ""Aspirin disrupts Fatigue"" supported by the sentence: ""In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.""?",False, -17225706,Aspirin disrupts transient ischemic attack,543,The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.,"Is the triple ""Aspirin disrupts transient ischemic attack"" supported by the sentence: ""The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.""?",False, -16676314,Aspirin disrupts ulcer disease,544,"Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.","Is the triple ""Aspirin disrupts ulcer disease"" supported by the sentence: ""Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.""?",False, -16484307,Aspirin disrupts acute lung injury,545,"METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.","Is the triple ""Aspirin disrupts acute lung injury"" supported by the sentence: ""METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.""?",False, -14296080,Aspirin disrupts Pregnancy,546,"Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.","Is the triple ""Aspirin disrupts Pregnancy"" supported by the sentence: ""Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.""?",False, -14068900,Aspirin disrupts active peptic ulcer disease,547,"In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.","Is the triple ""Aspirin disrupts active peptic ulcer disease"" supported by the sentence: ""In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.""?",False, -13892678,Aspirin disrupts breast neoplasm,548,Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.,"Is the triple ""Aspirin disrupts breast neoplasm"" supported by the sentence: ""Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.""?",False, -13449558,Aspirin disrupts colorectal neoplasm,549,"BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.","Is the triple ""Aspirin disrupts colorectal neoplasm"" supported by the sentence: ""BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.""?",False, -12947740,Aspirin disrupts diabetic retinopathy,550,"It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.","Is the triple ""Aspirin disrupts diabetic retinopathy"" supported by the sentence: ""It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.""?",False, -12815470,Aspirin disrupts atherosclerosis,551,"CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.","Is the triple ""Aspirin disrupts atherosclerosis"" supported by the sentence: ""CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.""?",False, -12714476,Aspirin disrupts cataract,552,Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.,"Is the triple ""Aspirin disrupts cataract"" supported by the sentence: ""Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.""?",False, -12478523,Aspirin disrupts preeclampsia,553,Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?,"Is the triple ""Aspirin disrupts preeclampsia"" supported by the sentence: ""Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?""?",False, -12450426,Aspirin disrupts Barrett esophagus,554,"Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].","Is the triple ""Aspirin disrupts Barrett esophagus"" supported by the sentence: ""Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].""?",False, -12023670,Aspirin disrupts hypertensive disorder,555,The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.,"Is the triple ""Aspirin disrupts hypertensive disorder"" supported by the sentence: ""The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.""?",False, -11827133,Aspirin disrupts diabetes mellitus,556,"Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.","Is the triple ""Aspirin disrupts diabetes mellitus"" supported by the sentence: ""Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.""?",False, -10318928,Aspirin disrupts Myalgia,557,"RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).","Is the triple ""Aspirin disrupts Myalgia"" supported by the sentence: ""RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).""?",False, -9742254,Aspirin disrupts adenoma,558,"BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.","Is the triple ""Aspirin disrupts adenoma"" supported by the sentence: ""BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.""?",False, -9148614,Aspirin disrupts neoplasm,559,"Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.","Is the triple ""Aspirin disrupts neoplasm"" supported by the sentence: ""Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.""?",False, -8526818,Aspirin disrupts myocardial infarction,560,"Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).","Is the triple ""Aspirin disrupts myocardial infarction"" supported by the sentence: ""Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).""?",False, -7995298,Aspirin disrupts Inflammation,561,RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.,"Is the triple ""Aspirin disrupts Inflammation"" supported by the sentence: ""RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.""?",False, -7878103,Aspirin disrupts prostate cancer,562,"Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).","Is the triple ""Aspirin disrupts prostate cancer"" supported by the sentence: ""Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).""?",False, -7775480,Aspirin disrupts Pain,563,"The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.","Is the triple ""Aspirin disrupts Pain"" supported by the sentence: ""The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.""?",False, -7723340,Aspirin disrupts stroke disorder,564,"Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.","Is the triple ""Aspirin disrupts stroke disorder"" supported by the sentence: ""Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.""?",False, -7712646,Aspirin disrupts coronary artery disorder,565,Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.,"Is the triple ""Aspirin disrupts coronary artery disorder"" supported by the sentence: ""Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.""?",False, -7261879,Aspirin disrupts thrombotic disease,566,"In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.","Is the triple ""Aspirin disrupts thrombotic disease"" supported by the sentence: ""In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.""?",False, -24597938,Aspirin prevents thrombophilia,567,Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.,"Is the triple ""Aspirin prevents thrombophilia"" supported by the sentence: ""Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.""?",False, -24091248,Aspirin prevents disseminated intravascular coagulation,568,Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.,"Is the triple ""Aspirin prevents disseminated intravascular coagulation"" supported by the sentence: ""Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.""?",False, -24015329,Aspirin prevents neoplasm of esophagus,569,"Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.","Is the triple ""Aspirin prevents neoplasm of esophagus"" supported by the sentence: ""Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.""?",False, -23042755,Aspirin prevents brain aneurysm,570,BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.,"Is the triple ""Aspirin prevents brain aneurysm"" supported by the sentence: ""BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.""?",False, -22291835,Aspirin prevents Hemorrhage,571,"CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.","Is the triple ""Aspirin prevents Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.""?",False, -21962376,Aspirin prevents venous thromboembolism,572,Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.,"Is the triple ""Aspirin prevents venous thromboembolism"" supported by the sentence: ""Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.""?",False, -21587985,Aspirin prevents blood coagulation disease,573,Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.,"Is the triple ""Aspirin prevents blood coagulation disease"" supported by the sentence: ""Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.""?",False, -21116357,Aspirin prevents schizophrenia,574,The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.,"Is the triple ""Aspirin prevents schizophrenia"" supported by the sentence: ""The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.""?",False, -20356983,Aspirin prevents acute lung injury,575,"Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).","Is the triple ""Aspirin prevents acute lung injury"" supported by the sentence: ""Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).""?",False, -20189716,Aspirin prevents brain infarction,576,"We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.","Is the triple ""Aspirin prevents brain infarction"" supported by the sentence: ""We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.""?",False, -18414184,Aspirin prevents multiple sclerosis,577,"Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.","Is the triple ""Aspirin prevents multiple sclerosis"" supported by the sentence: ""Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.""?",False, -18344373,Aspirin prevents bone fracture,578,"If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.","Is the triple ""Aspirin prevents bone fracture"" supported by the sentence: ""If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.""?",False, -17911903,Aspirin prevents adult acute respiratory distress syndrome,579,"Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.","Is the triple ""Aspirin prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.""?",False, -17240995,Aspirin prevents hepatocellular carcinoma,580,Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).,"Is the triple ""Aspirin prevents hepatocellular carcinoma"" supported by the sentence: ""Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).""?",False, -16163718,Aspirin prevents Sepsis,581,The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.,"Is the triple ""Aspirin prevents Sepsis"" supported by the sentence: ""The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.""?",False, -15608454,Aspirin prevents squamous cell carcinoma,582,"CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.","Is the triple ""Aspirin prevents squamous cell carcinoma"" supported by the sentence: ""CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.""?",False, -14796348,Aspirin prevents arthritic joint disease,583,"Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.","Is the triple ""Aspirin prevents arthritic joint disease"" supported by the sentence: ""Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.""?",False, -14183452,Aspirin prevents pneumonia,584,Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.,"Is the triple ""Aspirin prevents pneumonia"" supported by the sentence: ""Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.""?",False, -13992680,Aspirin prevents diabetes mellitus,585,We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.,"Is the triple ""Aspirin prevents diabetes mellitus"" supported by the sentence: ""We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.""?",False, -13992679,Aspirin prevents type 2 diabetes mellitus,586,CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.,"Is the triple ""Aspirin prevents type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.""?",False, -13770407,Aspirin prevents diabetic retinopathy,587,"According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.","Is the triple ""Aspirin prevents diabetic retinopathy"" supported by the sentence: ""According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.""?",False, -13624060,Aspirin prevents injury,588,The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.,"Is the triple ""Aspirin prevents injury"" supported by the sentence: ""The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.""?",False, -13536062,Aspirin prevents non-small cell lung carcinoma,589,CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.,"Is the triple ""Aspirin prevents non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.""?",False, -13041448,Aspirin prevents atrial fibrillation,590,"Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.","Is the triple ""Aspirin prevents atrial fibrillation"" supported by the sentence: ""Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.""?",False, -12791249,Aspirin prevents asthma,591,"CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.","Is the triple ""Aspirin prevents asthma"" supported by the sentence: ""CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.""?",False, -12594676,Aspirin prevents Fatigue,592,Aspirin reduces MS fatigue in some patients.,"Is the triple ""Aspirin prevents Fatigue"" supported by the sentence: ""Aspirin reduces MS fatigue in some patients.""?",False, -12361944,Aspirin prevents active peptic ulcer disease,593,CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.,"Is the triple ""Aspirin prevents active peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.""?",False, -12273189,Aspirin prevents Myalgia,594,BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.,"Is the triple ""Aspirin prevents Myalgia"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.""?",False, -11593026,Aspirin prevents colorectal neoplasm,595,Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.,"Is the triple ""Aspirin prevents colorectal neoplasm"" supported by the sentence: ""Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.""?",False, -11289178,Aspirin prevents migraine disorder,596,"The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.","Is the triple ""Aspirin prevents migraine disorder"" supported by the sentence: ""The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.""?",False, -11042545,Aspirin prevents Barrett esophagus,597,"BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.","Is the triple ""Aspirin prevents Barrett esophagus"" supported by the sentence: ""BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.""?",False, -10366572,Aspirin prevents cerebrovascular disorder,598,"Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.","Is the triple ""Aspirin prevents cerebrovascular disorder"" supported by the sentence: ""Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.""?",False, -10293726,Aspirin prevents prostate cancer,599,"The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.","Is the triple ""Aspirin prevents prostate cancer"" supported by the sentence: ""The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.""?",False, -10185706,Aspirin prevents colonic neoplasm,600,Can resistant starch and/or aspirin prevent the development of colonic neoplasia?,"Is the triple ""Aspirin prevents colonic neoplasm"" supported by the sentence: ""Can resistant starch and/or aspirin prevent the development of colonic neoplasia?""?",False, -10099399,Aspirin prevents atherosclerosis,601,Aspirin treatment reduced the development of atherosclerosis by approximately 47%.,"Is the triple ""Aspirin prevents atherosclerosis"" supported by the sentence: ""Aspirin treatment reduced the development of atherosclerosis by approximately 47%.""?",False, -10096705,Aspirin prevents cerebral infarction,602,"Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.","Is the triple ""Aspirin prevents cerebral infarction"" supported by the sentence: ""Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.""?",False, -10004143,Aspirin prevents blindness (disorder),603,"Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.","Is the triple ""Aspirin prevents blindness (disorder)"" supported by the sentence: ""Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.""?",False, -9665356,Aspirin prevents hypertensive disorder,604,CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.,"Is the triple ""Aspirin prevents hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.""?",False, -9388878,Aspirin prevents coronary artery disorder,605,[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].,"Is the triple ""Aspirin prevents coronary artery disorder"" supported by the sentence: ""[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].""?",False, -9150304,Aspirin prevents habitual spontaneous abortion,606,"Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.","Is the triple ""Aspirin prevents habitual spontaneous abortion"" supported by the sentence: ""Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.""?",False, -8853513,Aspirin prevents gastric ulcer,607,"All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.","Is the triple ""Aspirin prevents gastric ulcer"" supported by the sentence: ""All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.""?",False, -8755758,Aspirin prevents vascular disorder,608,"Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.","Is the triple ""Aspirin prevents vascular disorder"" supported by the sentence: ""Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.""?",False, -8494726,Aspirin prevents ulcer disease,609,"Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.","Is the triple ""Aspirin prevents ulcer disease"" supported by the sentence: ""Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.""?",False, -8347839,Aspirin prevents peptic ulcer disease,610,"METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.","Is the triple ""Aspirin prevents peptic ulcer disease"" supported by the sentence: ""METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.""?",False, -8325441,Aspirin prevents ischemic disease,611,Peri-operative aspirin can prevent post-operative ischemia and thrombosis.,"Is the triple ""Aspirin prevents ischemic disease"" supported by the sentence: ""Peri-operative aspirin can prevent post-operative ischemia and thrombosis.""?",False, -7877588,Aspirin prevents cardiovascular disorder,612,"METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.","Is the triple ""Aspirin prevents cardiovascular disorder"" supported by the sentence: ""METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.""?",False, -7852267,Aspirin prevents Headache,613,"Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.","Is the triple ""Aspirin prevents Headache"" supported by the sentence: ""Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.""?",False, -7716613,Aspirin prevents neoplasm,614,"Furthermore, aspirin decreased the total tumors (P < 0.05).","Is the triple ""Aspirin prevents neoplasm"" supported by the sentence: ""Furthermore, aspirin decreased the total tumors (P < 0.05).""?",False, -7603499,Aspirin prevents myocardial ischemia,615,Low dose warfarin and aspirin in preventing IHD.,"Is the triple ""Aspirin prevents myocardial ischemia"" supported by the sentence: ""Low dose warfarin and aspirin in preventing IHD.""?",False, -7487700,Aspirin prevents Inflammation,616,"Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.","Is the triple ""Aspirin prevents Inflammation"" supported by the sentence: ""Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.""?",False, -7457050,Aspirin prevents peripheral vascular disease,617,"Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.","Is the triple ""Aspirin prevents peripheral vascular disease"" supported by the sentence: ""Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.""?",False, -7455467,Aspirin prevents Ischemic stroke,618,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents Ischemic stroke"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, -7455466,Aspirin prevents stroke disorder,619,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents stroke disorder"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, -7455465,Aspirin prevents transient ischemic attack,620,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents transient ischemic attack"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, -7419265,Aspirin prevents heart disorder,621,"RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.","Is the triple ""Aspirin prevents heart disorder"" supported by the sentence: ""RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.""?",False, -7368248,Aspirin prevents thrombotic disease,622,Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.,"Is the triple ""Aspirin prevents thrombotic disease"" supported by the sentence: ""Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.""?",False, -7317027,Aspirin prevents preeclampsia,623,Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.,"Is the triple ""Aspirin prevents preeclampsia"" supported by the sentence: ""Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.""?",False, -7275741,Aspirin prevents acute coronary syndrome,624,"CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.","Is the triple ""Aspirin prevents acute coronary syndrome"" supported by the sentence: ""CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.""?",False, -7264064,Aspirin prevents Pain,625,Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.,"Is the triple ""Aspirin prevents Pain"" supported by the sentence: ""Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.""?",False, -7196018,Aspirin prevents myocardial infarction,626,"BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.","Is the triple ""Aspirin prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.""?",False, -7159192,Aspirin prevents fetal growth restriction,627,"If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.","Is the triple ""Aspirin prevents fetal growth restriction"" supported by the sentence: ""If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.""?",False, -7110859,Aspirin prevents thrombophilia due to thrombin defect,628,[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].,"Is the triple ""Aspirin prevents thrombophilia due to thrombin defect"" supported by the sentence: ""[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].""?",False, -22126985,Aspirin exacerbates gastric ulcer,629,"Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.","Is the triple ""Aspirin exacerbates gastric ulcer"" supported by the sentence: ""Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.""?",False, -21411566,Aspirin exacerbates macular degeneration,630,Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?,"Is the triple ""Aspirin exacerbates macular degeneration"" supported by the sentence: ""Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?""?",False, -21359197,Aspirin exacerbates acute coronary syndrome,631,Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.,"Is the triple ""Aspirin exacerbates acute coronary syndrome"" supported by the sentence: ""Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.""?",False, -26115547,Aspirin predisposes cerebral infarction,632,"Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.","Is the triple ""Aspirin predisposes cerebral infarction"" supported by the sentence: ""Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.""?",False, -25254777,Aspirin predisposes essential thrombocythemia,633,"Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.","Is the triple ""Aspirin predisposes essential thrombocythemia"" supported by the sentence: ""Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.""?",False, -23315977,Aspirin predisposes brain aneurysm,634,The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.,"Is the triple ""Aspirin predisposes brain aneurysm"" supported by the sentence: ""The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.""?",False, -21525767,Aspirin predisposes Fever,635,Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).,"Is the triple ""Aspirin predisposes Fever"" supported by the sentence: ""Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).""?",False, -21487721,Aspirin predisposes Hemorrhage,636,"The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).","Is the triple ""Aspirin predisposes Hemorrhage"" supported by the sentence: ""The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).""?",False, -20679052,Aspirin predisposes blood coagulation disease,637,"Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.","Is the triple ""Aspirin predisposes blood coagulation disease"" supported by the sentence: ""Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.""?",False, -20234206,Aspirin predisposes hepatocellular carcinoma,638,The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.,"Is the triple ""Aspirin predisposes hepatocellular carcinoma"" supported by the sentence: ""The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.""?",False, -20155873,Aspirin predisposes placental insufficiency,639,"There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.","Is the triple ""Aspirin predisposes placental insufficiency"" supported by the sentence: ""There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.""?",False, -19346376,Aspirin predisposes chronic renal failure syndrome,640,The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.,"Is the triple ""Aspirin predisposes chronic renal failure syndrome"" supported by the sentence: ""The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.""?",False, -18235965,Aspirin predisposes macular degeneration,641,[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].,"Is the triple ""Aspirin predisposes macular degeneration"" supported by the sentence: ""[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].""?",False, -17872103,Aspirin predisposes atrial fibrillation,642,"The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.","Is the triple ""Aspirin predisposes atrial fibrillation"" supported by the sentence: ""The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.""?",False, -17123250,Aspirin predisposes acute coronary syndrome,643,"In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.","Is the triple ""Aspirin predisposes acute coronary syndrome"" supported by the sentence: ""In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.""?",False, -16813141,Aspirin predisposes melanoma,644,"In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.","Is the triple ""Aspirin predisposes melanoma"" supported by the sentence: ""In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.""?",False, -16162173,Aspirin predisposes ulcerative colitis,645,"Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.","Is the triple ""Aspirin predisposes ulcerative colitis"" supported by the sentence: ""Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.""?",False, -15461534,Aspirin predisposes gastric ulcer,646,Aspirin specifically predisposes to gastric ulcer.,"Is the triple ""Aspirin predisposes gastric ulcer"" supported by the sentence: ""Aspirin specifically predisposes to gastric ulcer.""?",False, -14856258,Aspirin predisposes neoplasm of esophagus,647,"BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.","Is the triple ""Aspirin predisposes neoplasm of esophagus"" supported by the sentence: ""BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.""?",False, -14426809,Aspirin predisposes neoplasm,648,NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.,"Is the triple ""Aspirin predisposes neoplasm"" supported by the sentence: ""NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.""?",False, -14234947,Aspirin predisposes diabetes mellitus,649,"This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.","Is the triple ""Aspirin predisposes diabetes mellitus"" supported by the sentence: ""This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.""?",False, -14126301,Aspirin predisposes cerebrovascular disorder,650,"We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).","Is the triple ""Aspirin predisposes cerebrovascular disorder"" supported by the sentence: ""We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).""?",False, -14052964,Aspirin predisposes Inflammation,651,"Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).","Is the triple ""Aspirin predisposes Inflammation"" supported by the sentence: ""Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).""?",False, -14015029,Aspirin predisposes transient ischemic attack,652,"When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.","Is the triple ""Aspirin predisposes transient ischemic attack"" supported by the sentence: ""When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.""?",False, -13644771,Aspirin predisposes asthma,653,A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.,"Is the triple ""Aspirin predisposes asthma"" supported by the sentence: ""A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.""?",False, -13536064,Aspirin predisposes non-small cell lung carcinoma,654,Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.,"Is the triple ""Aspirin predisposes non-small cell lung carcinoma"" supported by the sentence: ""Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.""?",False, -13299957,Aspirin predisposes ovarian cancer,655,Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.,"Is the triple ""Aspirin predisposes ovarian cancer"" supported by the sentence: ""Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.""?",False, -12673405,Aspirin predisposes bone fracture,656,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Aspirin predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, -12382415,Aspirin predisposes colorectal neoplasm,657,"AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Aspirin predisposes colorectal neoplasm"" supported by the sentence: ""AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).""?",False, -11071059,Aspirin predisposes injury,658,"Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.","Is the triple ""Aspirin predisposes injury"" supported by the sentence: ""Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.""?",False, -10962122,Aspirin predisposes ischemic disease,659,"The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.","Is the triple ""Aspirin predisposes ischemic disease"" supported by the sentence: ""The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.""?",False, -10547299,Aspirin predisposes coronary artery disorder,660,"Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.","Is the triple ""Aspirin predisposes coronary artery disorder"" supported by the sentence: ""Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.""?",False, -10337650,Aspirin predisposes adenoma,661,CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.,"Is the triple ""Aspirin predisposes adenoma"" supported by the sentence: ""CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.""?",False, -9857077,Aspirin predisposes vascular disorder,662,"Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.","Is the triple ""Aspirin predisposes vascular disorder"" supported by the sentence: ""Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.""?",False, -9535755,Aspirin predisposes thrombotic disease,663,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes thrombotic disease"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, -9535754,Aspirin predisposes hypertensive disorder,664,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes hypertensive disorder"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, -9491661,Aspirin predisposes cardiovascular disorder,665,"In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).","Is the triple ""Aspirin predisposes cardiovascular disorder"" supported by the sentence: ""In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).""?",False, -9477464,Aspirin predisposes prostate cancer,666,"Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).","Is the triple ""Aspirin predisposes prostate cancer"" supported by the sentence: ""Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).""?",False, -9404829,Aspirin predisposes ulcer disease,667,"Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.","Is the triple ""Aspirin predisposes ulcer disease"" supported by the sentence: ""Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.""?",False, -8850172,Aspirin predisposes myocardial ischemia,668,"Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.","Is the triple ""Aspirin predisposes myocardial ischemia"" supported by the sentence: ""Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.""?",False, -8763743,Aspirin predisposes thrombophilia due to thrombin defect,669,The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.,"Is the triple ""Aspirin predisposes thrombophilia due to thrombin defect"" supported by the sentence: ""The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.""?",False, -8545255,Aspirin predisposes Ischemic stroke,670,"When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.","Is the triple ""Aspirin predisposes Ischemic stroke"" supported by the sentence: ""When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.""?",False, -7865543,Aspirin predisposes Headache,671,We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.,"Is the triple ""Aspirin predisposes Headache"" supported by the sentence: ""We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.""?",False, -7858710,Aspirin predisposes myocardial infarction,672,"In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.","Is the triple ""Aspirin predisposes myocardial infarction"" supported by the sentence: ""In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.""?",False, -7667039,Aspirin predisposes preeclampsia,673,"However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.","Is the triple ""Aspirin predisposes preeclampsia"" supported by the sentence: ""However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.""?",False, -7659453,Aspirin predisposes stroke disorder,674,RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.,"Is the triple ""Aspirin predisposes stroke disorder"" supported by the sentence: ""RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.""?",False, -7653535,Aspirin predisposes peptic ulcer disease,675,"BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.","Is the triple ""Aspirin predisposes peptic ulcer disease"" supported by the sentence: ""BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.""?",False, -7596288,Aspirin predisposes atherosclerosis,676,"OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.","Is the triple ""Aspirin predisposes atherosclerosis"" supported by the sentence: ""OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.""?",False, -7078619,Aspirin predisposes active peptic ulcer disease,677,Risk of major gastrointestinal bleeding with aspirin.,"Is the triple ""Aspirin predisposes active peptic ulcer disease"" supported by the sentence: ""Risk of major gastrointestinal bleeding with aspirin.""?",False, -23297288,Vemurafenib prevents neoplasm,678,Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.,"Is the triple ""Vemurafenib prevents neoplasm"" supported by the sentence: ""Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.""?",False, -22851133,Dabrafenib related to melanoma,679,"KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.","Is the triple ""Dabrafenib related to melanoma"" supported by the sentence: ""KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.""?",False, -18622575,Sodium heparin related to PROTAMINE SULFATE,680,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, -18622575,Sodium heparin related to PROTAMINE SULFATE,681,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, -26359747,Sodium heparin related to PROTAMINE SULFATE,682,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, -26359747,Sodium heparin related to PROTAMINE SULFATE,683,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, -24697302,Sodium heparin has part PROTAMINE SULFATE,684,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, -24697302,Sodium heparin has part PROTAMINE SULFATE,685,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, -10513644,Sodium heparin coexists with PROTAMINE SULFATE,686,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, -10513644,Sodium heparin coexists with PROTAMINE SULFATE,687,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, -15306394,Sodium heparin coexists with PROTAMINE SULFATE,688,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, -15306394,Sodium heparin coexists with PROTAMINE SULFATE,689,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, -10518221,Sodium heparin physically interacts with PROTAMINE SULFATE,690,[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].""?",False, -9906740,Sodium heparin physically interacts with PROTAMINE SULFATE,691,Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.""?",False, -8278260,Sodium heparin affects PROTAMINE SULFATE,692,Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.,"Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.""?",False, -9085295,Sodium heparin affects PROTAMINE SULFATE,693,"One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.","Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.""?",False, -25915149,Sodium monofluorophosphate related to dental caries,694,The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.,"Is the triple ""Sodium monofluorophosphate related to dental caries"" supported by the sentence: ""The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.""?",False, -25861359,Sodium monofluorophosphate disrupts allergic disease,695,Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.,"Is the triple ""Sodium monofluorophosphate disrupts allergic disease"" supported by the sentence: ""Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.""?",False, -19241020,Sodium Fluoride related to gingivitis,696,This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.,"Is the triple ""Sodium Fluoride related to gingivitis"" supported by the sentence: ""This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.""?",False, -17448182,Sodium Fluoride related to aortic valve stenosis,697,BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.,"Is the triple ""Sodium Fluoride related to aortic valve stenosis"" supported by the sentence: ""BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.""?",False, -9111981,Sodium Fluoride related to dental caries,698,This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.,"Is the triple ""Sodium Fluoride related to dental caries"" supported by the sentence: ""This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.""?",False, -25583763,Sodium Fluoride causes dental fluorosis,699,"The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.","Is the triple ""Sodium Fluoride causes dental fluorosis"" supported by the sentence: ""The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.""?",False, -23780312,Sodium Fluoride affects dental caries,700,OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.,"Is the triple ""Sodium Fluoride affects dental caries"" supported by the sentence: ""OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.""?",False, -18846793,Sodium Fluoride affects allergic disease,701,"At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).","Is the triple ""Sodium Fluoride affects allergic disease"" supported by the sentence: ""At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).""?",False, -25986070,Sodium Fluoride disrupts allergic disease,702,"In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.","Is the triple ""Sodium Fluoride disrupts allergic disease"" supported by the sentence: ""In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.""?",False, -14286543,Sodium Fluoride prevents gingivitis,703,"Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.","Is the triple ""Sodium Fluoride prevents gingivitis"" supported by the sentence: ""Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.""?",False, -10538561,Sodium Fluoride prevents periodontal disorder,704,Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.,"Is the triple ""Sodium Fluoride prevents periodontal disorder"" supported by the sentence: ""Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.""?",False, -10425615,Sodium Fluoride prevents dental caries,705,Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.,"Is the triple ""Sodium Fluoride prevents dental caries"" supported by the sentence: ""Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.""?",False, -19971424,Rifaximin related to irritable bowel syndrome,706,"In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.","Is the triple ""Rifaximin related to irritable bowel syndrome"" supported by the sentence: ""In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.""?",False, -17053293,Rifaximin related to hepatic encephalopathy,707,Rifaximin and lactulose have shown to be effective in HE.,"Is the triple ""Rifaximin related to hepatic encephalopathy"" supported by the sentence: ""Rifaximin and lactulose have shown to be effective in HE.""?",False, -18714048,Rifaximin causes irritable bowel syndrome,708,"Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.","Is the triple ""Rifaximin causes irritable bowel syndrome"" supported by the sentence: ""Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.""?",False, -8925773,Rifaximin causes diarrheal disease,709,"In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.","Is the triple ""Rifaximin causes diarrheal disease"" supported by the sentence: ""In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.""?",False, -25434952,Rifaximin affects alcoholic hepatitis,710,"Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.","Is the triple ""Rifaximin affects alcoholic hepatitis"" supported by the sentence: ""Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.""?",False, -24257624,Rifaximin affects Infection,711,"Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).","Is the triple ""Rifaximin affects Infection"" supported by the sentence: ""Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).""?",False, -20149851,Rifaximin affects Crohn disease,712,"In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.","Is the triple ""Rifaximin affects Crohn disease"" supported by the sentence: ""In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.""?",False, -19665399,Rifaximin affects diverticulitis,713,The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.,"Is the triple ""Rifaximin affects diverticulitis"" supported by the sentence: ""The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.""?",False, -18685028,Rifaximin affects irritable bowel syndrome,714,AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.,"Is the triple ""Rifaximin affects irritable bowel syndrome"" supported by the sentence: ""AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.""?",False, -16575444,Rifaximin affects hepatic encephalopathy,715,Rifaximin may have a dramatic effect on hepatic encephalopathy.,"Is the triple ""Rifaximin affects hepatic encephalopathy"" supported by the sentence: ""Rifaximin may have a dramatic effect on hepatic encephalopathy.""?",False, -21278571,Rifaximin prevents alcoholic hepatitis,716,"In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.","Is the triple ""Rifaximin prevents alcoholic hepatitis"" supported by the sentence: ""In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.""?",False, -16143515,Rifaximin prevents diverticulitis,717,No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.,"Is the triple ""Rifaximin prevents diverticulitis"" supported by the sentence: ""No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.""?",False, -15134586,Rifaximin prevents hepatic encephalopathy,718,Gut instinct: rifaximin for the prevention of hepatic encephalopathy.,"Is the triple ""Rifaximin prevents hepatic encephalopathy"" supported by the sentence: ""Gut instinct: rifaximin for the prevention of hepatic encephalopathy.""?",False, -11830138,Rifaximin prevents irritable bowel syndrome,719,Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.,"Is the triple ""Rifaximin prevents irritable bowel syndrome"" supported by the sentence: ""Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.""?",False, -11830137,Rifaximin prevents diarrheal disease,720,A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.,"Is the triple ""Rifaximin prevents diarrheal disease"" supported by the sentence: ""A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.""?",False, -15717459,Rifaximin predisposes hepatic encephalopathy,721,This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.,"Is the triple ""Rifaximin predisposes hepatic encephalopathy"" supported by the sentence: ""This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.""?",False, -25706307,Glycine related to cystic fibrosis,722,Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.,"Is the triple ""Glycine related to cystic fibrosis"" supported by the sentence: ""Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.""?",False, -20102524,Glycine related to psychotic disorder,723,"Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.","Is the triple ""Glycine related to psychotic disorder"" supported by the sentence: ""Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.""?",False, -17514096,Glycine related to hypertensive disorder,724,CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.,"Is the triple ""Glycine related to hypertensive disorder"" supported by the sentence: ""CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.""?",False, -13080824,Glycine related to Alzheimer disease,725,We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.,"Is the triple ""Glycine related to Alzheimer disease"" supported by the sentence: ""We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.""?",False, -12589996,Glycine related to nutritional disorder,726,Glycine production in severe childhood undernutrition.,"Is the triple ""Glycine related to nutritional disorder"" supported by the sentence: ""Glycine production in severe childhood undernutrition.""?",False, -7298031,Glycine related to schizophrenia,727,"Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.","Is the triple ""Glycine related to schizophrenia"" supported by the sentence: ""Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.""?",False, -17397486,Glycine causes Cognitive impairment,728,"The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.","Is the triple ""Glycine causes Cognitive impairment"" supported by the sentence: ""The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.""?",False, -17125423,Glycine affects asthma,729,"However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).","Is the triple ""Glycine affects asthma"" supported by the sentence: ""However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).""?",False, -7530162,Glycine affects schizophrenia,730,"To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.","Is the triple ""Glycine affects schizophrenia"" supported by the sentence: ""To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.""?",False, -12589998,Glycine produces nutritional disorder,731,OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.,"Is the triple ""Glycine produces nutritional disorder"" supported by the sentence: ""OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.""?",False, -16845009,Glycine disrupts Alzheimer disease,732,"[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.","Is the triple ""Glycine disrupts Alzheimer disease"" supported by the sentence: ""[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.""?",False, -12278394,Glycine prevents hypertensive disorder,733,"The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.","Is the triple ""Glycine prevents hypertensive disorder"" supported by the sentence: ""The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.""?",False, -15546112,Glycine predisposes asthma,734,"Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.","Is the triple ""Glycine predisposes asthma"" supported by the sentence: ""Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.""?",False, -16711324,Sorbitol related to injury,735,"CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.","Is the triple ""Sorbitol related to injury"" supported by the sentence: ""CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.""?",False, -10684679,Sorbitol related to constipation disorder,736,[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].,"Is the triple ""Sorbitol related to constipation disorder"" supported by the sentence: ""[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].""?",False, -20821510,Sorbitol causes constipation disorder,737,"However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.","Is the triple ""Sorbitol causes constipation disorder"" supported by the sentence: ""However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.""?",False, -15564538,Sorbitol causes injury,738,"Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.","Is the triple ""Sorbitol causes injury"" supported by the sentence: ""Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.""?",False, -17658899,Sorbitol affects osteoarthritis,739,"CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.","Is the triple ""Sorbitol affects osteoarthritis"" supported by the sentence: ""CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.""?",False, -26106951,Sorbitol prevents injury,740,"Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.","Is the triple ""Sorbitol prevents injury"" supported by the sentence: ""Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.""?",False, -10478248,Foscarnet affects cytomegalovirus infection,741,We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.,"Is the triple ""Foscarnet affects cytomegalovirus infection"" supported by the sentence: ""We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.""?",False, -10481132,Foscarnet prevents cytomegalovirus infection,742,The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.,"Is the triple ""Foscarnet prevents cytomegalovirus infection"" supported by the sentence: ""The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.""?",False, -22857734,Atogepant prevents migraine disorder,743,"Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.","Is the triple ""Atogepant prevents migraine disorder"" supported by the sentence: ""Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.""?",False, -25325960,Rimegepant prevents migraine disorder,744,"As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.","Is the triple ""Rimegepant prevents migraine disorder"" supported by the sentence: ""As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.""?",False, -21939131,Rimegepant prevents Pain,745,"The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.","Is the triple ""Rimegepant prevents Pain"" supported by the sentence: ""The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.""?",False, -10553741,ATROPINE related to poisoning,746,"[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].","Is the triple ""ATROPINE related to poisoning"" supported by the sentence: ""[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].""?",False, -19468294,ATROPINE causes Pain,747,"In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.","Is the triple ""ATROPINE causes Pain"" supported by the sentence: ""In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.""?",False, -18989245,ATROPINE causes digestive system disorder,748,"With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.","Is the triple ""ATROPINE causes digestive system disorder"" supported by the sentence: ""With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.""?",False, -14576640,ATROPINE causes myopia,749,"PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.","Is the triple ""ATROPINE causes myopia"" supported by the sentence: ""PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.""?",False, -10716177,ATROPINE causes Mydriasis,750,"The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.","Is the triple ""ATROPINE causes Mydriasis"" supported by the sentence: ""The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.""?",False, -10361041,ATROPINE causes amblyopia,751,"OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.","Is the triple ""ATROPINE causes amblyopia"" supported by the sentence: ""OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.""?",False, -9746341,ATROPINE causes poisoning,752,"Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.","Is the triple ""ATROPINE causes poisoning"" supported by the sentence: ""Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.""?",False, -9301311,ATROPINE causes cardiac arrest,753,"Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.","Is the triple ""ATROPINE causes cardiac arrest"" supported by the sentence: ""Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.""?",False, -8524259,ATROPINE causes Insulin resistance,754,Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.,"Is the triple ""ATROPINE causes Insulin resistance"" supported by the sentence: ""Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.""?",False, -8480152,ATROPINE causes Bradycardia,755,In 6-week-old rats atropine produced bradycardia instead of tachycardia.,"Is the triple ""ATROPINE causes Bradycardia"" supported by the sentence: ""In 6-week-old rats atropine produced bradycardia instead of tachycardia.""?",False, -26343406,ATROPINE affects hypoglycemia,756,"3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.""?",False, -23118209,ATROPINE affects Mydriasis,757,Both im and iv atropine had similar effects on weight loss rate and mydriasis.,"Is the triple ""ATROPINE affects Mydriasis"" supported by the sentence: ""Both im and iv atropine had similar effects on weight loss rate and mydriasis.""?",False, -19520979,ATROPINE affects hypoglycemia,758,"The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.""?",False, -12406813,ATROPINE affects cardiac arrest,759,Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.,"Is the triple ""ATROPINE affects cardiac arrest"" supported by the sentence: ""Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.""?",False, -11741867,ATROPINE affects Bradycardia,760,"LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.""?",False, -10264479,ATROPINE affects Hemorrhage,761,"Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.","Is the triple ""ATROPINE affects Hemorrhage"" supported by the sentence: ""Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.""?",False, -9293832,ATROPINE affects poisoning,762,"Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.","Is the triple ""ATROPINE affects poisoning"" supported by the sentence: ""Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.""?",False, -9041302,ATROPINE affects Bradycardia,763,"This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.""?",False, -7845760,ATROPINE affects Bradycardia,764,"CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.""?",False, -7111083,ATROPINE affects myopia,765,"These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.","Is the triple ""ATROPINE affects myopia"" supported by the sentence: ""These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.""?",False, -26141463,ATROPINE disrupts hypoglycemia,766,The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.,"Is the triple ""ATROPINE disrupts hypoglycemia"" supported by the sentence: ""The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.""?",False, -23143978,ATROPINE disrupts poisoning,767,"Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.","Is the triple ""ATROPINE disrupts poisoning"" supported by the sentence: ""Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.""?",False, -20133204,ATROPINE disrupts Pain,768,Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?,"Is the triple ""ATROPINE disrupts Pain"" supported by the sentence: ""Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?""?",False, -18168420,ATROPINE disrupts Bradycardia,769,"After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.","Is the triple ""ATROPINE disrupts Bradycardia"" supported by the sentence: ""After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.""?",False, -7111084,ATROPINE disrupts myopia,770,"Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.","Is the triple ""ATROPINE disrupts myopia"" supported by the sentence: ""Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.""?",False, -9676858,ATROPINE prevents poisoning,771,Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.,"Is the triple ""ATROPINE prevents poisoning"" supported by the sentence: ""Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.""?",False, -9198373,ATROPINE prevents myopia,772,"One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.","Is the triple ""ATROPINE prevents myopia"" supported by the sentence: ""One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.""?",False, -8451883,ATROPINE prevents cardiac arrest,773,Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.,"Is the triple ""ATROPINE prevents cardiac arrest"" supported by the sentence: ""Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.""?",False, -23699298,ATROPINE predisposes myopia,774,"Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).","Is the triple ""ATROPINE predisposes myopia"" supported by the sentence: ""Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).""?",False, -14640163,ATROPINE predisposes poisoning,775,"A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.","Is the triple ""ATROPINE predisposes poisoning"" supported by the sentence: ""A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.""?",False, -7953996,Tolcapone affects Parkinson disease,776,"Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.","Is the triple ""Tolcapone affects Parkinson disease"" supported by the sentence: ""Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.""?",False, -15643297,Entacapone related to Parkinson disease,777,OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.,"Is the triple ""Entacapone related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.""?",False, -10033650,Entacapone causes Parkinson disease,778,"Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.","Is the triple ""Entacapone causes Parkinson disease"" supported by the sentence: ""Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.""?",False, -15952178,Entacapone affects Parkinson disease,779,Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.,"Is the triple ""Entacapone affects Parkinson disease"" supported by the sentence: ""Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.""?",False, -20308336,Entacapone disrupts Parkinson disease,780,"Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).","Is the triple ""Entacapone disrupts Parkinson disease"" supported by the sentence: ""Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).""?",False, -25394620,Veliparib affects neoplasm,781,"[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).","Is the triple ""Veliparib affects neoplasm"" supported by the sentence: ""[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).""?",False, -21697473,Veliparib affects triple-negative breast carcinoma,782,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Veliparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, -21882624,Talazoparib causes neoplasm,783,"In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.","Is the triple ""Talazoparib causes neoplasm"" supported by the sentence: ""In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.""?",False, -22572154,Talazoparib affects neoplasm,784,The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.,"Is the triple ""Talazoparib affects neoplasm"" supported by the sentence: ""The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.""?",False, -21697476,Talazoparib affects triple-negative breast carcinoma,785,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Talazoparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, -22916819,Talazoparib prevents neoplasm,786,Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.,"Is the triple ""Talazoparib prevents neoplasm"" supported by the sentence: ""Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.""?",False, -24451977,Olaparib related to triple-negative breast carcinoma,787,"Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.","Is the triple ""Olaparib related to triple-negative breast carcinoma"" supported by the sentence: ""Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.""?",False, -25473017,Olaparib causes pancreatic ductal adenocarcinoma,788,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes pancreatic ductal adenocarcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, -25473016,Olaparib causes non-small cell lung carcinoma,789,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes non-small cell lung carcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, -22160122,Olaparib causes head and neck neoplasm,790,"Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.","Is the triple ""Olaparib causes head and neck neoplasm"" supported by the sentence: ""Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.""?",False, -24770500,Olaparib affects castration-resistant prostate carcinoma,791,Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.,"Is the triple ""Olaparib affects castration-resistant prostate carcinoma"" supported by the sentence: ""Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.""?",False, -24672020,Olaparib affects prostate cancer,792,"Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.","Is the triple ""Olaparib affects prostate cancer"" supported by the sentence: ""Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.""?",False, -22977330,Olaparib affects neoplasm,793,TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.,"Is the triple ""Olaparib affects neoplasm"" supported by the sentence: ""TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.""?",False, -21697474,Olaparib affects triple-negative breast carcinoma,794,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Olaparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, -24201965,Olaparib prevents Neoplasm Metastasis,795,The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.,"Is the triple ""Olaparib prevents Neoplasm Metastasis"" supported by the sentence: ""The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.""?",False, -27698235,Capsaicin related to arthritic joint disease,796,"Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.","Is the triple ""Capsaicin related to arthritic joint disease"" supported by the sentence: ""Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.""?",False, -22276323,Capsaicin related to herpes zoster,797,Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.,"Is the triple ""Capsaicin related to herpes zoster"" supported by the sentence: ""Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.""?",False, -13200623,Capsaicin related to migraine disorder,798,Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.,"Is the triple ""Capsaicin related to migraine disorder"" supported by the sentence: ""Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.""?",False, -11537529,Capsaicin related to Cough,799,"Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.","Is the triple ""Capsaicin related to Cough"" supported by the sentence: ""Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.""?",False, -10028696,Capsaicin related to diabetic neuropathy,800,"CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.","Is the triple ""Capsaicin related to diabetic neuropathy"" supported by the sentence: ""CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.""?",False, -8608120,Capsaicin related to osteoarthritis,801,The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.,"Is the triple ""Capsaicin related to osteoarthritis"" supported by the sentence: ""The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.""?",False, -8470968,Capsaicin related to postherpetic neuralgia,802,"These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.","Is the triple ""Capsaicin related to postherpetic neuralgia"" supported by the sentence: ""These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.""?",False, -8246278,Capsaicin related to neuralgia,803,3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.,"Is the triple ""Capsaicin related to neuralgia"" supported by the sentence: ""3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.""?",False, -7965643,Capsaicin related to Pruritus,804,"As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).","Is the triple ""Capsaicin related to Pruritus"" supported by the sentence: ""As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).""?",False, -7239245,Capsaicin related to Pain,805,Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.,"Is the triple ""Capsaicin related to Pain"" supported by the sentence: ""Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.""?",False, -26554289,Capsaicin causes stroke disorder,806,MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.,"Is the triple ""Capsaicin causes stroke disorder"" supported by the sentence: ""MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.""?",False, -24505933,Capsaicin causes Muscle spasm,807,"The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.","Is the triple ""Capsaicin causes Muscle spasm"" supported by the sentence: ""The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.""?",False, -18391785,Capsaicin causes neuralgia,808,Can topical capsaicin induce a neuropathic pain?,"Is the triple ""Capsaicin causes neuralgia"" supported by the sentence: ""Can topical capsaicin induce a neuropathic pain?""?",False, -16420383,Capsaicin causes migraine disorder,809,CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.,"Is the triple ""Capsaicin causes migraine disorder"" supported by the sentence: ""CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.""?",False, -11163813,Capsaicin causes arthritic joint disease,810,Capsaicin-induced joint inflammation is not blocked by local anesthesia.,"Is the triple ""Capsaicin causes arthritic joint disease"" supported by the sentence: ""Capsaicin-induced joint inflammation is not blocked by local anesthesia.""?",False, -9650510,Capsaicin causes Myalgia,811,Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.,"Is the triple ""Capsaicin causes Myalgia"" supported by the sentence: ""Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.""?",False, -8975038,Capsaicin causes Vomiting,812,"E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).","Is the triple ""Capsaicin causes Vomiting"" supported by the sentence: ""E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).""?",False, -8261437,Capsaicin causes Cough,813,The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.,"Is the triple ""Capsaicin causes Cough"" supported by the sentence: ""The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.""?",False, -7430731,Capsaicin causes Pruritus,814,"Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.","Is the triple ""Capsaicin causes Pruritus"" supported by the sentence: ""Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.""?",False, -7414435,Capsaicin causes Pain,815,Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.,"Is the triple ""Capsaicin causes Pain"" supported by the sentence: ""Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.""?",False, -27524804,Capsaicin affects arthritic joint disease,816,Effects of capsaicin in temporomandibular joint arthritis in rats.,"Is the triple ""Capsaicin affects arthritic joint disease"" supported by the sentence: ""Effects of capsaicin in temporomandibular joint arthritis in rats.""?",False, -25438971,Capsaicin affects brain injury,817,"Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.","Is the triple ""Capsaicin affects brain injury"" supported by the sentence: ""Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.""?",False, -19404541,Capsaicin affects neuroma,818,"There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.","Is the triple ""Capsaicin affects neuroma"" supported by the sentence: ""There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.""?",False, -15791019,Capsaicin affects Pruritus,819,"A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).""?",False, -10951234,Capsaicin affects stroke disorder,820,"Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.","Is the triple ""Capsaicin affects stroke disorder"" supported by the sentence: ""Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.""?",False, -10764355,Capsaicin affects Pain,821,"Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.""?",False, -10290167,Capsaicin affects Pruritus,822,"As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.""?",False, -10171204,Capsaicin affects neuralgia,823,"Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.","Is the triple ""Capsaicin affects neuralgia"" supported by the sentence: ""Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.""?",False, -8975035,Capsaicin affects Vomiting,824,The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.,"Is the triple ""Capsaicin affects Vomiting"" supported by the sentence: ""The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.""?",False, -8515286,Capsaicin affects Pain,825,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, -8515285,Capsaicin affects postherpetic neuralgia,826,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects postherpetic neuralgia"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, -8441743,Capsaicin affects Cough,827,Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.""?",False, -7281158,Capsaicin affects Cough,828,Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.""?",False, -18283970,Capsaicin disrupts Pain,829,"Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.","Is the triple ""Capsaicin disrupts Pain"" supported by the sentence: ""Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.""?",False, -17652809,Capsaicin disrupts arthritic joint disease,830,Capsaicin suppresses substance P-induced joint inflammation in the rat.,"Is the triple ""Capsaicin disrupts arthritic joint disease"" supported by the sentence: ""Capsaicin suppresses substance P-induced joint inflammation in the rat.""?",False, -14643733,Capsaicin disrupts breast neoplasm,831,"Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.","Is the triple ""Capsaicin disrupts breast neoplasm"" supported by the sentence: ""Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.""?",False, -9869751,Capsaicin disrupts Cough,832,"To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.","Is the triple ""Capsaicin disrupts Cough"" supported by the sentence: ""To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.""?",False, -8160008,Capsaicin disrupts Pruritus,833,RESULTS: Capsaicin suppressed completely itch in all patients.,"Is the triple ""Capsaicin disrupts Pruritus"" supported by the sentence: ""RESULTS: Capsaicin suppressed completely itch in all patients.""?",False, -25438980,Capsaicin prevents brain injury,834,Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.,"Is the triple ""Capsaicin prevents brain injury"" supported by the sentence: ""Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.""?",False, -20404597,Capsaicin prevents postherpetic neuralgia,835,The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.,"Is the triple ""Capsaicin prevents postherpetic neuralgia"" supported by the sentence: ""The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.""?",False, -17168513,Capsaicin prevents migraine disorder,836,"Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.","Is the triple ""Capsaicin prevents migraine disorder"" supported by the sentence: ""Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.""?",False, -16978917,Capsaicin prevents neuralgia,837,Capsaicin treatment is one method to reduce neuropathic pain.,"Is the triple ""Capsaicin prevents neuralgia"" supported by the sentence: ""Capsaicin treatment is one method to reduce neuropathic pain.""?",False, -15822967,Capsaicin prevents stroke disorder,838,We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).,"Is the triple ""Capsaicin prevents stroke disorder"" supported by the sentence: ""We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).""?",False, -10290168,Capsaicin prevents Pruritus,839,"In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.","Is the triple ""Capsaicin prevents Pruritus"" supported by the sentence: ""In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.""?",False, -8608117,Capsaicin prevents osteoarthritis,840,The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.,"Is the triple ""Capsaicin prevents osteoarthritis"" supported by the sentence: ""The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.""?",False, -8246280,Capsaicin prevents Pain,841,"RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.","Is the triple ""Capsaicin prevents Pain"" supported by the sentence: ""RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.""?",False, -14706687,Capsaicin predisposes Pain,842,These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.,"Is the triple ""Capsaicin predisposes Pain"" supported by the sentence: ""These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.""?",False, -24021484,Nusinersen causes spinal muscular atrophy,843,"Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.","Is the triple ""Nusinersen causes spinal muscular atrophy"" supported by the sentence: ""Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.""?",False, -22907909,Nusinersen affects spinal muscular atrophy,844,More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.,"Is the triple ""Nusinersen affects spinal muscular atrophy"" supported by the sentence: ""More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.""?",False, -27681284,Hyaluronic acid sodium salt related to alcoholic hepatitis,845,"These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.","Is the triple ""Hyaluronic acid sodium salt related to alcoholic hepatitis"" supported by the sentence: ""These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.""?",False, -26794689,Hyaluronic acid sodium salt related to carpal tunnel syndrome,846,"In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.","Is the triple ""Hyaluronic acid sodium salt related to carpal tunnel syndrome"" supported by the sentence: ""In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.""?",False, -20903427,Hyaluronic acid sodium salt related to Skin ulcer,847,Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.,"Is the triple ""Hyaluronic acid sodium salt related to Skin ulcer"" supported by the sentence: ""Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.""?",False, -18915649,Hyaluronic acid sodium salt related to Hyaluronidase,848,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, -18915649,Hyaluronic acid sodium salt related to Hyaluronidase,849,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, -15362486,Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder,850,OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.,"Is the triple ""Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder"" supported by the sentence: ""OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.""?",False, -14268478,Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease,851,Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.,"Is the triple ""Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease"" supported by the sentence: ""Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.""?",False, -9147590,Hyaluronic acid sodium salt related to dry eye syndrome,852,Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.,"Is the triple ""Hyaluronic acid sodium salt related to dry eye syndrome"" supported by the sentence: ""Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.""?",False, -7458117,Hyaluronic acid sodium salt related to osteoarthritis,853,OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.,"Is the triple ""Hyaluronic acid sodium salt related to osteoarthritis"" supported by the sentence: ""OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.""?",False, -17074499,Hyaluronic acid sodium salt related to Hyaluronidase,854,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, -17074499,Hyaluronic acid sodium salt related to Hyaluronidase,855,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, -12401778,Hyaluronic acid sodium salt has part Hyaluronidase,856,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, -12401778,Hyaluronic acid sodium salt has part Hyaluronidase,857,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, -11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,858,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, -11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,859,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, -7287149,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,860,The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.""?",False, -7699622,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,861,Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.""?",False, -12146167,Hyaluronic acid sodium salt causes osteoarthritis,862,We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).,"Is the triple ""Hyaluronic acid sodium salt causes osteoarthritis"" supported by the sentence: ""We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).""?",False, -8938037,Hyaluronic acid sodium salt affects osteoarthritis,863,"RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.","Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.""?",False, -8541022,Hyaluronic acid sodium salt affects osteoarthritis,864,The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.,"Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.""?",False, -7683831,Hyaluronic acid sodium salt affects Hyaluronidase,865,Such small HA fragments are generated from the degradation of HA by hyaluronidase.,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""Such small HA fragments are generated from the degradation of HA by hyaluronidase.""?",False, -7895314,Hyaluronic acid sodium salt affects Hyaluronidase,866,RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).""?",False, -18839068,Hyaluronic acid sodium salt produces Hyaluronidase,867,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, -18839068,Hyaluronic acid sodium salt produces Hyaluronidase,868,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, -9813251,Hyaluronic acid sodium salt produces Hyaluronidase,869,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, -9813251,Hyaluronic acid sodium salt produces Hyaluronidase,870,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, -17165364,Hyaluronic acid sodium salt has input Hyaluronidase,871,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, -17165364,Hyaluronic acid sodium salt has input Hyaluronidase,872,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, -23839601,Hyaluronic acid sodium salt disrupts dry eye syndrome,873,Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.,"Is the triple ""Hyaluronic acid sodium salt disrupts dry eye syndrome"" supported by the sentence: ""Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.""?",False, -22764727,Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder,874,"Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.","Is the triple ""Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder"" supported by the sentence: ""Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.""?",False, -7155073,Hyaluronic acid sodium salt disrupts osteoarthritis,875,"Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.","Is the triple ""Hyaluronic acid sodium salt disrupts osteoarthritis"" supported by the sentence: ""Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.""?",False, -18262848,Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease,876,Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.,"Is the triple ""Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.""?",False, -11511344,Hyaluronic acid sodium salt prevents osteoarthritis,877,The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.,"Is the triple ""Hyaluronic acid sodium salt prevents osteoarthritis"" supported by the sentence: ""The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.""?",False, -21264578,Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder,878,"CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.","Is the triple ""Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder"" supported by the sentence: ""CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.""?",False, -11605823,Hyaluronic acid sodium salt predisposes osteoarthritis,879,CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.,"Is the triple ""Hyaluronic acid sodium salt predisposes osteoarthritis"" supported by the sentence: ""CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.""?",False, -24659748,Zoledronic acid related to osteoporosis,880,"Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.","Is the triple ""Zoledronic acid related to osteoporosis"" supported by the sentence: ""Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.""?",False, -18902207,Zoledronic acid causes Marchiafava-Bignami disease,881,Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.,"Is the triple ""Zoledronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.""?",False, -18856931,Zoledronic acid causes hepatocellular carcinoma,882,"This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.","Is the triple ""Zoledronic acid causes hepatocellular carcinoma"" supported by the sentence: ""This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.""?",False, -13083414,Zoledronic acid causes bone fracture,883,"The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.","Is the triple ""Zoledronic acid causes bone fracture"" supported by the sentence: ""The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.""?",False, -21044659,Zoledronic acid affects Marchiafava-Bignami disease,884,Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.,"Is the triple ""Zoledronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.""?",False, -19059032,Zoledronic acid affects bone osteosarcoma,885,"BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.","Is the triple ""Zoledronic acid affects bone osteosarcoma"" supported by the sentence: ""BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.""?",False, -13892047,Zoledronic acid affects bone fracture,886,Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.,"Is the triple ""Zoledronic acid affects bone fracture"" supported by the sentence: ""Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.""?",False, -13448998,Zoledronic acid affects osteonecrosis,887,"Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.","Is the triple ""Zoledronic acid affects osteonecrosis"" supported by the sentence: ""Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.""?",False, -9617769,Zoledronic acid affects osteoporosis,888,Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.,"Is the triple ""Zoledronic acid affects osteoporosis"" supported by the sentence: ""Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.""?",False, -24472422,Zoledronic acid disrupts sarcoma,889,Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.,"Is the triple ""Zoledronic acid disrupts sarcoma"" supported by the sentence: ""Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.""?",False, -20879055,Zoledronic acid disrupts Neoplasm Metastasis,890,"Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.","Is the triple ""Zoledronic acid disrupts Neoplasm Metastasis"" supported by the sentence: ""Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.""?",False, -20879053,Zoledronic acid disrupts Pain,891,Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.,"Is the triple ""Zoledronic acid disrupts Pain"" supported by the sentence: ""Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.""?",False, -13311906,Zoledronic acid disrupts hepatocellular carcinoma,892,"Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.","Is the triple ""Zoledronic acid disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.""?",False, -9617771,Zoledronic acid disrupts bone fracture,893,"If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.","Is the triple ""Zoledronic acid disrupts bone fracture"" supported by the sentence: ""If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.""?",False, -22662537,Zoledronic acid prevents osteoporosis,894,"As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.","Is the triple ""Zoledronic acid prevents osteoporosis"" supported by the sentence: ""As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.""?",False, -20148397,Zoledronic acid prevents osteonecrosis,895,Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.,"Is the triple ""Zoledronic acid prevents osteonecrosis"" supported by the sentence: ""Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.""?",False, -13621414,Zoledronic acid prevents bone fracture,896,"5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.","Is the triple ""Zoledronic acid prevents bone fracture"" supported by the sentence: ""5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.""?",False, -12127006,Zoledronic acid prevents Marchiafava-Bignami disease,897,CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.,"Is the triple ""Zoledronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.""?",False, -20851623,Zoledronic acid predisposes bone fracture,898,"A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.","Is the triple ""Zoledronic acid predisposes bone fracture"" supported by the sentence: ""A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.""?",False, -15272127,Zoledronic acid predisposes osteonecrosis,899,"Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.","Is the triple ""Zoledronic acid predisposes osteonecrosis"" supported by the sentence: ""Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.""?",False, -14006582,Risedronic acid prevents osteoporosis,900,"A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.","Is the triple ""Risedronic acid prevents osteoporosis"" supported by the sentence: ""A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.""?",False, -17290459,IBANDRONIC ACID affects osteonecrosis,901,"Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.","Is the triple ""IBANDRONIC ACID affects osteonecrosis"" supported by the sentence: ""Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.""?",False, -9797983,IBANDRONIC ACID affects Neoplasm Metastasis,902,Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.,"Is the triple ""IBANDRONIC ACID affects Neoplasm Metastasis"" supported by the sentence: ""Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.""?",False, -15290649,IBANDRONIC ACID prevents bone disorder,903,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""IBANDRONIC ACID prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, -13697992,IBANDRONIC ACID prevents Pain,904,"Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.","Is the triple ""IBANDRONIC ACID prevents Pain"" supported by the sentence: ""Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.""?",False, -10307139,IBANDRONIC ACID prevents postmenopausal osteoporosis,905,"OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.","Is the triple ""IBANDRONIC ACID prevents postmenopausal osteoporosis"" supported by the sentence: ""OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.""?",False, -10028971,IBANDRONIC ACID prevents osteoporosis,906,These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.,"Is the triple ""IBANDRONIC ACID prevents osteoporosis"" supported by the sentence: ""These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.""?",False, -18363632,IBANDRONIC ACID predisposes Abdominal pain,907,"The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.","Is the triple ""IBANDRONIC ACID predisposes Abdominal pain"" supported by the sentence: ""The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.""?",False, -9434475,IBANDRONIC ACID predisposes osteoporosis,908,The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.,"Is the triple ""IBANDRONIC ACID predisposes osteoporosis"" supported by the sentence: ""The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.""?",False, -17514758,Alendronic acid related to osteoarthritis,909,OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.,"Is the triple ""Alendronic acid related to osteoarthritis"" supported by the sentence: ""OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.""?",False, -14283477,Alendronic acid related to osteoporosis,910,"To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.","Is the triple ""Alendronic acid related to osteoporosis"" supported by the sentence: ""To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.""?",False, -11575454,Alendronic acid related to postmenopausal osteoporosis,911,Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.,"Is the triple ""Alendronic acid related to postmenopausal osteoporosis"" supported by the sentence: ""Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.""?",False, -14254304,Alendronic acid causes asthma,912,Alendronate-induced asthma.,"Is the triple ""Alendronic acid causes asthma"" supported by the sentence: ""Alendronate-induced asthma.""?",False, -14049757,Alendronic acid causes osteoporosis,913,The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.,"Is the triple ""Alendronic acid causes osteoporosis"" supported by the sentence: ""The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.""?",False, -11710947,Alendronic acid causes Marchiafava-Bignami disease,914,Alendronate as an effective countermeasure to disuse induced bone loss.,"Is the triple ""Alendronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate as an effective countermeasure to disuse induced bone loss.""?",False, -25124892,Alendronic acid affects Marchiafava-Bignami disease,915,"EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.","Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.""?",False, -24296937,Alendronic acid affects bone disorder,916,The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.,"Is the triple ""Alendronic acid affects bone disorder"" supported by the sentence: ""The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.""?",False, -17701514,Alendronic acid affects osteoarthritis,917,This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.,"Is the triple ""Alendronic acid affects osteoarthritis"" supported by the sentence: ""This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.""?",False, -14769549,Alendronic acid affects postmenopausal osteoporosis,918,The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.,"Is the triple ""Alendronic acid affects postmenopausal osteoporosis"" supported by the sentence: ""The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.""?",False, -12316243,Alendronic acid affects osteoporosis,919,"Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.","Is the triple ""Alendronic acid affects osteoporosis"" supported by the sentence: ""Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.""?",False, -12136907,Alendronic acid affects periodontitis,920,We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.,"Is the triple ""Alendronic acid affects periodontitis"" supported by the sentence: ""We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.""?",False, -8809813,Alendronic acid affects Marchiafava-Bignami disease,921,We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.,"Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.""?",False, -22627610,Alendronic acid disrupts aortic valve stenosis,922,Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.,"Is the triple ""Alendronic acid disrupts aortic valve stenosis"" supported by the sentence: ""Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.""?",False, -17047070,Alendronic acid disrupts prostate cancer,923,"For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).","Is the triple ""Alendronic acid disrupts prostate cancer"" supported by the sentence: ""For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).""?",False, -9109277,Alendronic acid disrupts Marchiafava-Bignami disease,924,"Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.","Is the triple ""Alendronic acid disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.""?",False, -8466156,Alendronic acid disrupts postmenopausal osteoporosis,925,(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.,"Is the triple ""Alendronic acid disrupts postmenopausal osteoporosis"" supported by the sentence: ""(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.""?",False, -24628288,Alendronic acid prevents osteoarthritis,926,"Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.","Is the triple ""Alendronic acid prevents osteoarthritis"" supported by the sentence: ""Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.""?",False, -15290647,Alendronic acid prevents bone disorder,927,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""Alendronic acid prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, -7495571,Alendronic acid prevents osteoporosis,928,"Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.","Is the triple ""Alendronic acid prevents osteoporosis"" supported by the sentence: ""Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.""?",False, -7314446,Alendronic acid prevents Marchiafava-Bignami disease,929,Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.,"Is the triple ""Alendronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.""?",False, -7150371,Alendronic acid prevents postmenopausal osteoporosis,930,Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).,"Is the triple ""Alendronic acid prevents postmenopausal osteoporosis"" supported by the sentence: ""Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).""?",False, -25381093,Alendronic acid predisposes osteoporosis,931,"In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.","Is the triple ""Alendronic acid predisposes osteoporosis"" supported by the sentence: ""In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.""?",False, -22975353,Alendronic acid predisposes Marchiafava-Bignami disease,932,We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.,"Is the triple ""Alendronic acid predisposes Marchiafava-Bignami disease"" supported by the sentence: ""We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.""?",False, -12652815,Pamidronic acid related to osteoporosis,933,The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.,"Is the triple ""Pamidronic acid related to osteoporosis"" supported by the sentence: ""The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.""?",False, -7541169,Pamidronic acid related to plasma cell myeloma,934,Effect of calcitriol and pamidronate in multiple myeloma.,"Is the triple ""Pamidronic acid related to plasma cell myeloma"" supported by the sentence: ""Effect of calcitriol and pamidronate in multiple myeloma.""?",False, -12040766,Pamidronic acid affects plasma cell myeloma,935,"MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.","Is the triple ""Pamidronic acid affects plasma cell myeloma"" supported by the sentence: ""MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.""?",False, -10860757,Pamidronic acid affects osteoporosis,936,The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.,"Is the triple ""Pamidronic acid affects osteoporosis"" supported by the sentence: ""The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.""?",False, -9170219,Pamidronic acid prevents osteoporosis,937,Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.,"Is the triple ""Pamidronic acid prevents osteoporosis"" supported by the sentence: ""Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.""?",False, -9315699,Octyl methoxycinnamate prevents sunburn,938,"In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.","Is the triple ""Octyl methoxycinnamate prevents sunburn"" supported by the sentence: ""In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.""?",False, -10529058,4-Aminobenzoic acid coexists with Procaine,939,[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].,"Is the triple ""4-Aminobenzoic acid coexists with Procaine"" supported by the sentence: ""[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].""?",False, -25771688,Nitrazepam causes epilepsy,940,The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.,"Is the triple ""Nitrazepam causes epilepsy"" supported by the sentence: ""The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.""?",False, -19206956,Nitrazepam affects depressive disorder,941,The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.,"Is the triple ""Nitrazepam affects depressive disorder"" supported by the sentence: ""The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.""?",False, -25737609,Nitrazepam disrupts epilepsy,942,"Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.","Is the triple ""Nitrazepam disrupts epilepsy"" supported by the sentence: ""Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.""?",False, -7322742,Nitrazepam prevents epilepsy,943,NZP was discontinued if there was < 50% seizure reduction or significant side effects.,"Is the triple ""Nitrazepam prevents epilepsy"" supported by the sentence: ""NZP was discontinued if there was < 50% seizure reduction or significant side effects.""?",False, -25779340,Flurazepam causes depressive disorder,944,"Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.","Is the triple ""Flurazepam causes depressive disorder"" supported by the sentence: ""Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.""?",False, -19092155,Triazolam causes depressive disorder,945,"In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.","Is the triple ""Triazolam causes depressive disorder"" supported by the sentence: ""In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.""?",False, -16852864,Triazolam causes insomnia,946,"This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.","Is the triple ""Triazolam causes insomnia"" supported by the sentence: ""This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.""?",False, -27224077,Triazolam affects insomnia,947,OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).,"Is the triple ""Triazolam affects insomnia"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).""?",False, -15159227,Triazolam disrupts anxiety,948,Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.,"Is the triple ""Triazolam disrupts anxiety"" supported by the sentence: ""Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.""?",False, -24702695,Midazolam related to delirium,949,"The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.","Is the triple ""Midazolam related to delirium"" supported by the sentence: ""The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.""?",False, -16327495,Midazolam related to obesity disorder,950,The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.,"Is the triple ""Midazolam related to obesity disorder"" supported by the sentence: ""The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.""?",False, -17503618,Midazolam causes Nausea,951,Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.,"Is the triple ""Midazolam causes Nausea"" supported by the sentence: ""Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.""?",False, -13087342,Midazolam causes status epilepticus,952,PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.,"Is the triple ""Midazolam causes status epilepticus"" supported by the sentence: ""PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.""?",False, -12880145,Midazolam causes delirium,953,"Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.","Is the triple ""Midazolam causes delirium"" supported by the sentence: ""Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.""?",False, -12134398,Midazolam causes brain injury,954,"Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.","Is the triple ""Midazolam causes brain injury"" supported by the sentence: ""Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.""?",False, -11162624,Midazolam causes Pain,955,Sedation with midazolam leads to reduced pain after dental surgery.,"Is the triple ""Midazolam causes Pain"" supported by the sentence: ""Sedation with midazolam leads to reduced pain after dental surgery.""?",False, -10221339,Midazolam causes injury,956,"CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.","Is the triple ""Midazolam causes injury"" supported by the sentence: ""CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.""?",False, -10197463,Midazolam causes epilepsy,957,Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.,"Is the triple ""Midazolam causes epilepsy"" supported by the sentence: ""Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.""?",False, -7739374,Midazolam causes hypotensive disorder,958,"For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.","Is the triple ""Midazolam causes hypotensive disorder"" supported by the sentence: ""For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.""?",False, -7211473,Midazolam causes depressive disorder,959,We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.,"Is the triple ""Midazolam causes depressive disorder"" supported by the sentence: ""We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.""?",False, -7104276,Midazolam causes dissociative amnesia,960,"In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.","Is the triple ""Midazolam causes dissociative amnesia"" supported by the sentence: ""In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.""?",False, -27271852,Midazolam affects Pruritus,961,"In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.","Is the triple ""Midazolam affects Pruritus"" supported by the sentence: ""In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.""?",False, -26121850,Midazolam affects Pain,962,"Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.","Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.""?",False, -25522494,Midazolam affects anxiety,963,"Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.""?",False, -22514965,Midazolam affects anxiety,964,"A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.""?",False, -22203290,Midazolam affects post-traumatic stress disorder,965,The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.,"Is the triple ""Midazolam affects post-traumatic stress disorder"" supported by the sentence: ""The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.""?",False, -21411467,Midazolam affects Suicidal ideation,966,"Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).","Is the triple ""Midazolam affects Suicidal ideation"" supported by the sentence: ""Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).""?",False, -20820424,Midazolam affects injury,967,"Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.","Is the triple ""Midazolam affects injury"" supported by the sentence: ""Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.""?",False, -20230773,Midazolam affects hypotensive disorder,968,Sudden hypotension associated with midazolam and sufentanil.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""Sudden hypotension associated with midazolam and sufentanil.""?",False, -19683992,Midazolam affects injury,969,Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.,"Is the triple ""Midazolam affects injury"" supported by the sentence: ""Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.""?",False, -18986257,Midazolam affects neoplasm,970,Studies have also shown that midazolam has an anticancer effect on various tumors.,"Is the triple ""Midazolam affects neoplasm"" supported by the sentence: ""Studies have also shown that midazolam has an anticancer effect on various tumors.""?",False, -18893940,Midazolam affects hypertensive disorder,971,"Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.","Is the triple ""Midazolam affects hypertensive disorder"" supported by the sentence: ""Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.""?",False, -18670184,Midazolam affects hypotensive disorder,972,"According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.","Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.""?",False, -18644607,Midazolam affects neuralgia,973,Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.,"Is the triple ""Midazolam affects neuralgia"" supported by the sentence: ""Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.""?",False, -18331473,Midazolam affects status epilepticus,974,"The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.","Is the triple ""Midazolam affects status epilepticus"" supported by the sentence: ""The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.""?",False, -17655582,Midazolam affects Cough,975,Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.,"Is the triple ""Midazolam affects Cough"" supported by the sentence: ""Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.""?",False, -12605496,Midazolam affects dissociative amnesia,976,Midazolam tends to have more favorable effects on amnesia.,"Is the triple ""Midazolam affects dissociative amnesia"" supported by the sentence: ""Midazolam tends to have more favorable effects on amnesia.""?",False, -12154940,Midazolam affects Nausea,977,"We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.","Is the triple ""Midazolam affects Nausea"" supported by the sentence: ""We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.""?",False, -11981571,Midazolam affects delirium,978,The development of delirium was associated with the medication midazolam taken perioperatively.,"Is the triple ""Midazolam affects delirium"" supported by the sentence: ""The development of delirium was associated with the medication midazolam taken perioperatively.""?",False, -8867560,Midazolam affects Pain,979,Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.,"Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.""?",False, -8871799,Midazolam affects hypotensive disorder,980,The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.""?",False, -8701804,Midazolam affects epilepsy,981,Nasal midazolam effects on childhood acute seizures.,"Is the triple ""Midazolam affects epilepsy"" supported by the sentence: ""Nasal midazolam effects on childhood acute seizures.""?",False, -8569605,Midazolam affects brain injury,982,"Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.","Is the triple ""Midazolam affects brain injury"" supported by the sentence: ""Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.""?",False, -7116661,Midazolam affects Postoperative Nausea and Vomiting,983,The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.,"Is the triple ""Midazolam affects Postoperative Nausea and Vomiting"" supported by the sentence: ""The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.""?",False, -20025306,Midazolam disrupts Pruritus,984,"Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.","Is the triple ""Midazolam disrupts Pruritus"" supported by the sentence: ""Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.""?",False, -18424847,Midazolam disrupts status epilepticus,985,"Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.","Is the triple ""Midazolam disrupts status epilepticus"" supported by the sentence: ""Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.""?",False, -16150704,Midazolam disrupts Cough,986,CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.,"Is the triple ""Midazolam disrupts Cough"" supported by the sentence: ""CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.""?",False, -14733481,Midazolam disrupts neuralgia,987,Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.,"Is the triple ""Midazolam disrupts neuralgia"" supported by the sentence: ""Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.""?",False, -13861580,Midazolam disrupts Pain,988,"CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.","Is the triple ""Midazolam disrupts Pain"" supported by the sentence: ""CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.""?",False, -9443524,Midazolam disrupts epilepsy,989,"PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.","Is the triple ""Midazolam disrupts epilepsy"" supported by the sentence: ""PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.""?",False, -7819099,Midazolam disrupts anxiety,990,CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.,"Is the triple ""Midazolam disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.""?",False, -21663738,Midazolam prevents anxiety,991,This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.,"Is the triple ""Midazolam prevents anxiety"" supported by the sentence: ""This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.""?",False, -20820423,Midazolam prevents injury,992,Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.,"Is the triple ""Midazolam prevents injury"" supported by the sentence: ""Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.""?",False, -17322994,Midazolam prevents Aggressive behavior,993,"Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.","Is the triple ""Midazolam prevents Aggressive behavior"" supported by the sentence: ""Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.""?",False, -16397367,Midazolam prevents status epilepticus,994,"Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.","Is the triple ""Midazolam prevents status epilepticus"" supported by the sentence: ""Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.""?",False, -13467675,Midazolam prevents Nausea,995,Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.,"Is the triple ""Midazolam prevents Nausea"" supported by the sentence: ""Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.""?",False, -11373548,Midazolam prevents Cough,996,"CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.","Is the triple ""Midazolam prevents Cough"" supported by the sentence: ""CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.""?",False, -11041799,Midazolam prevents bone fracture,997,"Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.","Is the triple ""Midazolam prevents bone fracture"" supported by the sentence: ""Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.""?",False, -9493413,Midazolam prevents epilepsy,998,"Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.","Is the triple ""Midazolam prevents epilepsy"" supported by the sentence: ""Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.""?",False, -8653279,Midazolam prevents Sepsis,999,"Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.","Is the triple ""Midazolam prevents Sepsis"" supported by the sentence: ""Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.""?",False, -8569600,Midazolam prevents brain injury,1000,"Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.","Is the triple ""Midazolam prevents brain injury"" supported by the sentence: ""Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.""?",False, -8151023,Midazolam prevents Pain,1001,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Midazolam prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, -7116663,Midazolam prevents Postoperative Nausea and Vomiting,1002,We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.,"Is the triple ""Midazolam prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.""?",False, -16657523,Midazolam exacerbates Sepsis,1003,"METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.","Is the triple ""Midazolam exacerbates Sepsis"" supported by the sentence: ""METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.""?",False, -19191198,Midazolam predisposes dissociative amnesia,1004,This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.,"Is the triple ""Midazolam predisposes dissociative amnesia"" supported by the sentence: ""This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.""?",False, -18422952,Midazolam predisposes status epilepticus,1005,"Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.","Is the triple ""Midazolam predisposes status epilepticus"" supported by the sentence: ""Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.""?",False, -11981572,Midazolam predisposes delirium,1006,The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.,"Is the triple ""Midazolam predisposes delirium"" supported by the sentence: ""The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.""?",False, -22402246,Brotizolam disrupts anxiety,1007,"Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.","Is the triple ""Brotizolam disrupts anxiety"" supported by the sentence: ""Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.""?",False, -12312025,Ganirelix related to polycystic ovary syndrome,1008,LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.,"Is the triple ""Ganirelix related to polycystic ovary syndrome"" supported by the sentence: ""LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.""?",False, -14831488,Cetrorelix disrupts benign prostatic hyperplasia,1009,Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.,"Is the triple ""Cetrorelix disrupts benign prostatic hyperplasia"" supported by the sentence: ""Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.""?",False, -18703871,Cetrorelix prevents endometriosis,1010,"CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.","Is the triple ""Cetrorelix prevents endometriosis"" supported by the sentence: ""CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.""?",False, -18874469,Methoxsalen related to Deoxyribonucleic acid,1011,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, -18874469,Methoxsalen related to Deoxyribonucleic acid,1012,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, -12069194,Methoxsalen related to mycosis fungoides,1013,Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.,"Is the triple ""Methoxsalen related to mycosis fungoides"" supported by the sentence: ""Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.""?",False, -8610329,Methoxsalen related to psoriasis,1014,"Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.","Is the triple ""Methoxsalen related to psoriasis"" supported by the sentence: ""Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.""?",False, -26218137,Methoxsalen related to Deoxyribonucleic acid,1015,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, -26218137,Methoxsalen related to Deoxyribonucleic acid,1016,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, -7172075,Methoxsalen coexists with Deoxyribonucleic acid,1017,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, -7172075,Methoxsalen coexists with Deoxyribonucleic acid,1018,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, -26761340,Methoxsalen coexists with Deoxyribonucleic acid,1019,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, -26761340,Methoxsalen coexists with Deoxyribonucleic acid,1020,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, -7782040,Methoxsalen physically interacts with Deoxyribonucleic acid,1021,"New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.","Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.""?",False, -12022213,Methoxsalen physically interacts with Deoxyribonucleic acid,1022,MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.,"Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.""?",False, -9512596,Methoxsalen affects Deoxyribonucleic acid,1023,"Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.""?",False, -19709381,Methoxsalen affects Deoxyribonucleic acid,1024,"Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.""?",False, -8674128,Trioxsalen coexists with Deoxyribonucleic acid,1025,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, -8674128,Trioxsalen coexists with Deoxyribonucleic acid,1026,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, -8674127,Trioxsalen physically interacts with Deoxyribonucleic acid,1027,"In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.","Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.""?",False, -25732039,Trioxsalen physically interacts with Deoxyribonucleic acid,1028,The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.,"Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.""?",False, -16826513,Trioxsalen affects Deoxyribonucleic acid,1029,"Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.","Is the triple ""Trioxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.""?",False, -9717834,Bisoprolol related to hypertensive disorder,1030,"Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.","Is the triple ""Bisoprolol related to hypertensive disorder"" supported by the sentence: ""Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.""?",False, -17484309,Bisoprolol affects Hemorrhage,1031,CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.,"Is the triple ""Bisoprolol affects Hemorrhage"" supported by the sentence: ""CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.""?",False, -14633716,Bisoprolol affects hypertensive disorder,1032,CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.,"Is the triple ""Bisoprolol affects hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.""?",False, -13150765,Bisoprolol affects pulmonary arterial hypertension,1033,"MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.","Is the triple ""Bisoprolol affects pulmonary arterial hypertension"" supported by the sentence: ""MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.""?",False, -24626572,Bisoprolol disrupts Hemorrhage,1034,No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.,"Is the triple ""Bisoprolol disrupts Hemorrhage"" supported by the sentence: ""No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.""?",False, -23315135,Bisoprolol prevents Hemorrhage,1035,"Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).","Is the triple ""Bisoprolol prevents Hemorrhage"" supported by the sentence: ""Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).""?",False, -26817035,Esmolol related to atrial fibrillation,1036,"In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.","Is the triple ""Esmolol related to atrial fibrillation"" supported by the sentence: ""In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.""?",False, -13689489,Esmolol causes atrial fibrillation,1037,Esmolol or atropine markedly increased the threshold for AF induction.,"Is the triple ""Esmolol causes atrial fibrillation"" supported by the sentence: ""Esmolol or atropine markedly increased the threshold for AF induction.""?",False, -20072391,Esmolol affects toxic shock syndrome,1038,The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.,"Is the triple ""Esmolol affects toxic shock syndrome"" supported by the sentence: ""The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.""?",False, -19519833,Esmolol affects Pain,1039,"Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.","Is the triple ""Esmolol affects Pain"" supported by the sentence: ""Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.""?",False, -16877299,Esmolol prevents Pain,1040,Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.,"Is the triple ""Esmolol prevents Pain"" supported by the sentence: ""Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.""?",False, -10180097,Esmolol prevents ischemia reperfusion injury,1041,"Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.","Is the triple ""Esmolol prevents ischemia reperfusion injury"" supported by the sentence: ""Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.""?",False, -9581320,Esmolol prevents atrial fibrillation,1042,We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.,"Is the triple ""Esmolol prevents atrial fibrillation"" supported by the sentence: ""We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.""?",False, -18235527,Oxygen related to pulmonary fibrosis,1043,"However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.","Is the triple ""Oxygen related to pulmonary fibrosis"" supported by the sentence: ""However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.""?",False, -18193743,Oxygen related to neoplasm,1044,Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.,"Is the triple ""Oxygen related to neoplasm"" supported by the sentence: ""Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.""?",False, -17303485,Oxygen related to Hypoxemia,1045,"CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.","Is the triple ""Oxygen related to Hypoxemia"" supported by the sentence: ""CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.""?",False, -14116536,Oxygen related to Shock,1046,The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.,"Is the triple ""Oxygen related to Shock"" supported by the sentence: ""The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.""?",False, -13587155,Oxygen related to injury,1047,These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.,"Is the triple ""Oxygen related to injury"" supported by the sentence: ""These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.""?",False, -8813011,Oxygen related to ischemia reperfusion injury,1048,Cardiac toxicity of singlet oxygen: implication in reperfusion injury.,"Is the triple ""Oxygen related to ischemia reperfusion injury"" supported by the sentence: ""Cardiac toxicity of singlet oxygen: implication in reperfusion injury.""?",False, -21893162,Oxygen causes neoplasm,1049,"Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.","Is the triple ""Oxygen causes neoplasm"" supported by the sentence: ""Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.""?",False, -19992109,Oxygen causes ischemia reperfusion injury,1050,The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.,"Is the triple ""Oxygen causes ischemia reperfusion injury"" supported by the sentence: ""The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.""?",False, -8243272,Oxygen causes vascular disorder,1051,"Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.","Is the triple ""Oxygen causes vascular disorder"" supported by the sentence: ""Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.""?",False, -8114891,Oxygen causes injury,1052,New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.,"Is the triple ""Oxygen causes injury"" supported by the sentence: ""New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.""?",False, -7992845,Oxygen causes Hypoxemia,1053,"At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.","Is the triple ""Oxygen causes Hypoxemia"" supported by the sentence: ""At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.""?",False, -7752235,Oxygen causes stroke disorder,1054,We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.,"Is the triple ""Oxygen causes stroke disorder"" supported by the sentence: ""We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.""?",False, -23272853,Oxygen affects neoplasm,1055,"The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.""?",False, -22206348,Oxygen affects neoplasm,1056,"Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.""?",False, -19397332,Oxygen affects Hypoxemia,1057,"Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.","Is the triple ""Oxygen affects Hypoxemia"" supported by the sentence: ""Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.""?",False, -13060611,Oxygen affects Shock,1058,Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.,"Is the triple ""Oxygen affects Shock"" supported by the sentence: ""Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.""?",False, -13638133,Oxygen produces Hypoxemia,1059,"However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.","Is the triple ""Oxygen produces Hypoxemia"" supported by the sentence: ""However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.""?",False, -13264427,Oxygen produces neoplasm,1060,"The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.","Is the triple ""Oxygen produces neoplasm"" supported by the sentence: ""The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.""?",False, -12483211,Oxygen disrupts Hypoxemia,1061,Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.,"Is the triple ""Oxygen disrupts Hypoxemia"" supported by the sentence: ""Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.""?",False, -11682185,Oxygen disrupts neoplasm,1062,"While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.","Is the triple ""Oxygen disrupts neoplasm"" supported by the sentence: ""While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.""?",False, -16806319,Oxygen prevents injury,1063,"Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.","Is the triple ""Oxygen prevents injury"" supported by the sentence: ""Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.""?",False, -17280500,Oxygen predisposes injury,1064,"Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.","Is the triple ""Oxygen predisposes injury"" supported by the sentence: ""Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.""?",False, -7575686,Metoprolol subclass of O-Demethylmetoprolol,1065,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of O-Demethylmetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, -7575685,Metoprolol subclass of alpha-Hydroxymetoprolol,1066,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of alpha-Hydroxymetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, -27359356,Metoprolol related to alpha-Hydroxymetoprolol,1067,"When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.","Is the triple ""Metoprolol related to alpha-Hydroxymetoprolol"" supported by the sentence: ""When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.""?",False, -27639377,Metoprolol derives from alpha-Hydroxymetoprolol,1068,"METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.","Is the triple ""Metoprolol derives from alpha-Hydroxymetoprolol"" supported by the sentence: ""METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.""?",False, -26548288,Metoprolol physically interacts with O-Demethylmetoprolol,1069,"Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.","Is the triple ""Metoprolol physically interacts with O-Demethylmetoprolol"" supported by the sentence: ""Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.""?",False, -21656554,Metoprolol physically interacts with alpha-Hydroxymetoprolol,1070,Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.,"Is the triple ""Metoprolol physically interacts with alpha-Hydroxymetoprolol"" supported by the sentence: ""Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.""?",False, -27101524,Metoprolol causes ventricular tachycardia,1071,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular tachycardia"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, -27101519,Metoprolol causes ventricular fibrillation,1072,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular fibrillation"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, -20648435,Metoprolol causes cardiac rhythm disease,1073,"Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.","Is the triple ""Metoprolol causes cardiac rhythm disease"" supported by the sentence: ""Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.""?",False, -14625318,Metoprolol causes hypertensive disorder,1074,[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].,"Is the triple ""Metoprolol causes hypertensive disorder"" supported by the sentence: ""[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].""?",False, -19013861,Metoprolol affects obesity disorder,1075,"Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.","Is the triple ""Metoprolol affects obesity disorder"" supported by the sentence: ""Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.""?",False, -17630974,Metoprolol affects coronary artery disorder,1076,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects coronary artery disorder"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, -17630973,Metoprolol affects atherosclerosis,1077,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects atherosclerosis"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, -16547648,Metoprolol affects myocardial infarction,1078,Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.,"Is the triple ""Metoprolol affects myocardial infarction"" supported by the sentence: ""Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.""?",False, -12751741,Metoprolol affects cardiac rhythm disease,1079,"Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.","Is the triple ""Metoprolol affects cardiac rhythm disease"" supported by the sentence: ""Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.""?",False, -11341339,Metoprolol affects hypertensive disorder,1080,The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).,"Is the triple ""Metoprolol affects hypertensive disorder"" supported by the sentence: ""The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).""?",False, -16802112,Metoprolol disrupts atrial fibrillation,1081,CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.,"Is the triple ""Metoprolol disrupts atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.""?",False, -14314818,Metoprolol disrupts atherosclerosis,1082,"These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.","Is the triple ""Metoprolol disrupts atherosclerosis"" supported by the sentence: ""These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.""?",False, -13648308,Metoprolol disrupts ventricular tachycardia,1083,Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.,"Is the triple ""Metoprolol disrupts ventricular tachycardia"" supported by the sentence: ""Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.""?",False, -12510783,Metoprolol disrupts cardiac rhythm disease,1084,"However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.","Is the triple ""Metoprolol disrupts cardiac rhythm disease"" supported by the sentence: ""However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.""?",False, -16624344,Metoprolol prevents cardiac rhythm disease,1085,Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.,"Is the triple ""Metoprolol prevents cardiac rhythm disease"" supported by the sentence: ""Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.""?",False, -13530896,Metoprolol prevents myocardial infarction,1086,"POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.","Is the triple ""Metoprolol prevents myocardial infarction"" supported by the sentence: ""POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.""?",False, -13366014,Metoprolol prevents hypertensive disorder,1087,Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.,"Is the triple ""Metoprolol prevents hypertensive disorder"" supported by the sentence: ""Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.""?",False, -13268090,Metoprolol prevents ventricular fibrillation,1088,"CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.","Is the triple ""Metoprolol prevents ventricular fibrillation"" supported by the sentence: ""CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.""?",False, -9428080,Metoprolol prevents atrial fibrillation,1089,Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.,"Is the triple ""Metoprolol prevents atrial fibrillation"" supported by the sentence: ""Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.""?",False, -7236533,Metoprolol prevents atherosclerosis,1090,"The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.","Is the triple ""Metoprolol prevents atherosclerosis"" supported by the sentence: ""The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.""?",False, -22663349,Metoprolol predisposes atrial fibrillation,1091,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Metoprolol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, -25990864,Acebutolol affects hypertensive disorder,1092,The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.,"Is the triple ""Acebutolol affects hypertensive disorder"" supported by the sentence: ""The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.""?",False, -25995365,Acebutolol prevents hypertensive disorder,1093,"Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.","Is the triple ""Acebutolol prevents hypertensive disorder"" supported by the sentence: ""Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.""?",False, -24856753,Pretomanid affects multidrug-resistant tuberculosis,1094,"Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.","Is the triple ""Pretomanid affects multidrug-resistant tuberculosis"" supported by the sentence: ""Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.""?",False, -17848125,Nitrogen related to chronic obstructive pulmonary disease,1095,"Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.","Is the triple ""Nitrogen related to chronic obstructive pulmonary disease"" supported by the sentence: ""Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.""?",False, -15192685,Nitrogen related to ischemia reperfusion injury,1096,"Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.","Is the triple ""Nitrogen related to ischemia reperfusion injury"" supported by the sentence: ""Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.""?",False, -10505101,Nitrogen related to burn,1097,The effect on the nitrogen metabolism of severely burned patients.,"Is the triple ""Nitrogen related to burn"" supported by the sentence: ""The effect on the nitrogen metabolism of severely burned patients.""?",False, -10425490,Nitrogen related to cystic fibrosis,1098,Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.,"Is the triple ""Nitrogen related to cystic fibrosis"" supported by the sentence: ""Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.""?",False, -16934805,Nitrogen causes ischemia reperfusion injury,1099,"METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.","Is the triple ""Nitrogen causes ischemia reperfusion injury"" supported by the sentence: ""METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.""?",False, -13030867,Nitrogen affects ischemia reperfusion injury,1100,Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.,"Is the triple ""Nitrogen affects ischemia reperfusion injury"" supported by the sentence: ""Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.""?",False, -9020164,Nitrogen affects severe acute respiratory syndrome,1101,"The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.","Is the triple ""Nitrogen affects severe acute respiratory syndrome"" supported by the sentence: ""The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.""?",False, -17493096,Nitrogen predisposes ischemia reperfusion injury,1102,BACKGROUND: Nitrogen may contribute to reperfusion injury.,"Is the triple ""Nitrogen predisposes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Nitrogen may contribute to reperfusion injury.""?",False, -25313239,Helium related to status asthmaticus,1103,[Use of helium and oxygen mixtures in status asthmaticus].,"Is the triple ""Helium related to status asthmaticus"" supported by the sentence: ""[Use of helium and oxygen mixtures in status asthmaticus].""?",False, -12274245,Helium related to chronic obstructive pulmonary disease,1104,The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.,"Is the triple ""Helium related to chronic obstructive pulmonary disease"" supported by the sentence: ""The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.""?",False, -15248421,Carbon Dioxide related to Pain,1105,"Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.","Is the triple ""Carbon Dioxide related to Pain"" supported by the sentence: ""Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.""?",False, -11844945,Carbon Dioxide related to sleep apnea syndrome,1106,"Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.","Is the triple ""Carbon Dioxide related to sleep apnea syndrome"" supported by the sentence: ""Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.""?",False, -10575797,Carbon Dioxide related to respiratory failure,1107,Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.,"Is the triple ""Carbon Dioxide related to respiratory failure"" supported by the sentence: ""Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.""?",False, -7620110,Carbon Dioxide related to panic disorder,1108,To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.,"Is the triple ""Carbon Dioxide related to panic disorder"" supported by the sentence: ""To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.""?",False, -16671036,Carbon Dioxide causes panic disorder,1109,"We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.","Is the triple ""Carbon Dioxide causes panic disorder"" supported by the sentence: ""We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.""?",False, -11038318,Carbon Dioxide causes respiratory failure,1110,"BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.","Is the triple ""Carbon Dioxide causes respiratory failure"" supported by the sentence: ""BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.""?",False, -20071308,Carbon Dioxide affects Pain,1111,"INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.","Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.""?",False, -15771768,Carbon Dioxide affects Pain,1112,Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.,"Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.""?",False, -15385933,Carbon Dioxide affects panic disorder,1113,"In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.","Is the triple ""Carbon Dioxide affects panic disorder"" supported by the sentence: ""In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.""?",False, -14460813,Carbon Dioxide affects respiratory failure,1114,"Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.","Is the triple ""Carbon Dioxide affects respiratory failure"" supported by the sentence: ""Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.""?",False, -15294247,Carbon Dioxide produces respiratory failure,1115,"As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.","Is the triple ""Carbon Dioxide produces respiratory failure"" supported by the sentence: ""As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.""?",False, -11946282,Carbon Dioxide disrupts Pain,1116,BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.,"Is the triple ""Carbon Dioxide disrupts Pain"" supported by the sentence: ""BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.""?",False, -17126447,Carbon Dioxide predisposes Pain,1117,OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.,"Is the triple ""Carbon Dioxide predisposes Pain"" supported by the sentence: ""OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.""?",False, -11404382,Carbon Dioxide predisposes panic disorder,1118,"Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.","Is the triple ""Carbon Dioxide predisposes panic disorder"" supported by the sentence: ""Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.""?",False, -7432027,Carbon Dioxide predisposes respiratory failure,1119,"At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.","Is the triple ""Carbon Dioxide predisposes respiratory failure"" supported by the sentence: ""At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.""?",False, -24776228,Ethambutol causes tuberculosis,1120,From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.,"Is the triple ""Ethambutol causes tuberculosis"" supported by the sentence: ""From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.""?",False, -25946331,Ethambutol affects tuberculosis,1121,Effects of ethambutol on tuberculous diseases of the eye.,"Is the triple ""Ethambutol affects tuberculosis"" supported by the sentence: ""Effects of ethambutol on tuberculous diseases of the eye.""?",False, -24875144,Ethambutol affects pulmonary tuberculosis,1122,Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).,"Is the triple ""Ethambutol affects pulmonary tuberculosis"" supported by the sentence: ""Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).""?",False, -25597027,Ethambutol disrupts tuberculosis,1123,Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.,"Is the triple ""Ethambutol disrupts tuberculosis"" supported by the sentence: ""Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.""?",False, -18704735,Ethambutol prevents tuberculosis,1124,"After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.","Is the triple ""Ethambutol prevents tuberculosis"" supported by the sentence: ""After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.""?",False, -14472959,Pyrazinamide affects pulmonary tuberculosis,1125,Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.,"Is the triple ""Pyrazinamide affects pulmonary tuberculosis"" supported by the sentence: ""Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.""?",False, -10149898,Pyrazinamide affects tuberculosis,1126,Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.,"Is the triple ""Pyrazinamide affects tuberculosis"" supported by the sentence: ""Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.""?",False, -8080030,Pyrazinamide prevents tuberculosis,1127,Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.,"Is the triple ""Pyrazinamide prevents tuberculosis"" supported by the sentence: ""Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.""?",False, -27556045,Pyrazinamide predisposes tuberculosis,1128,"The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.","Is the triple ""Pyrazinamide predisposes tuberculosis"" supported by the sentence: ""The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.""?",False, -26376727,Androstanolone related to hypogonadism,1129,"The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.","Is the triple ""Androstanolone related to hypogonadism"" supported by the sentence: ""The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.""?",False, -22807780,Androstanolone affects hypogonadism,1130,"In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.","Is the triple ""Androstanolone affects hypogonadism"" supported by the sentence: ""In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.""?",False, -7261548,Nebivolol related to essential hypertension,1131,Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.,"Is the triple ""Nebivolol related to essential hypertension"" supported by the sentence: ""Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.""?",False, -10251853,Nebivolol affects hypertensive disorder,1132,In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.,"Is the triple ""Nebivolol affects hypertensive disorder"" supported by the sentence: ""In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.""?",False, -20026875,Nebivolol prevents cardiovascular disorder,1133,Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.,"Is the triple ""Nebivolol prevents cardiovascular disorder"" supported by the sentence: ""Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.""?",False, -10251855,Nebivolol prevents hypertensive disorder,1134,These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.,"Is the triple ""Nebivolol prevents hypertensive disorder"" supported by the sentence: ""These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.""?",False, -11558481,Nebivolol exacerbates hypertensive disorder,1135,"Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.","Is the triple ""Nebivolol exacerbates hypertensive disorder"" supported by the sentence: ""Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.""?",False, -17527026,Landiolol related to atrial fibrillation,1136,INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.,"Is the triple ""Landiolol related to atrial fibrillation"" supported by the sentence: ""INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.""?",False, -14267268,Landiolol affects atrial fibrillation,1137,The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.,"Is the triple ""Landiolol affects atrial fibrillation"" supported by the sentence: ""The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.""?",False, -16074351,Landiolol disrupts atrial fibrillation,1138,"RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).","Is the triple ""Landiolol disrupts atrial fibrillation"" supported by the sentence: ""RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).""?",False, -21882778,Landiolol prevents cardiac rhythm disease,1139,INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.,"Is the triple ""Landiolol prevents cardiac rhythm disease"" supported by the sentence: ""INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.""?",False, -14873276,Landiolol prevents atrial fibrillation,1140,"Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.","Is the triple ""Landiolol prevents atrial fibrillation"" supported by the sentence: ""Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.""?",False, -20190145,Landiolol predisposes atrial fibrillation,1141,"In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.","Is the triple ""Landiolol predisposes atrial fibrillation"" supported by the sentence: ""In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.""?",False, -26530979,Oxandrolone related to nutritional disorder,1142,"For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.","Is the triple ""Oxandrolone related to nutritional disorder"" supported by the sentence: ""For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.""?",False, -17138340,Oxandrolone related to Fanconi anemia,1143,"CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.","Is the triple ""Oxandrolone related to Fanconi anemia"" supported by the sentence: ""CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.""?",False, -12117784,Oxandrolone related to Turner syndrome,1144,"Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.","Is the triple ""Oxandrolone related to Turner syndrome"" supported by the sentence: ""Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.""?",False, -11269262,Oxandrolone related to burn,1145,The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.,"Is the triple ""Oxandrolone related to burn"" supported by the sentence: ""The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.""?",False, -7561027,Cefepime causes toxic shock syndrome,1146,"Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.","Is the triple ""Cefepime causes toxic shock syndrome"" supported by the sentence: ""Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.""?",False, -19437692,Cefepime affects bacterial infectious disease,1147,"OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.","Is the triple ""Cefepime affects bacterial infectious disease"" supported by the sentence: ""OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.""?",False, -17947468,Cefepime affects infectious disease,1148,"CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.","Is the triple ""Cefepime affects infectious disease"" supported by the sentence: ""CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.""?",False, -19800344,Cefepime disrupts infectious disease,1149,"CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.","Is the triple ""Cefepime disrupts infectious disease"" supported by the sentence: ""CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.""?",False, -26336145,"Hydrocortisone butyrate related to dermatitis, atopic",1150,[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].,"Is the triple ""Hydrocortisone butyrate related to dermatitis, atopic"" supported by the sentence: ""[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].""?",False, -26243703,Hydrocortisone butyrate related to skin disorder,1151,[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].,"Is the triple ""Hydrocortisone butyrate related to skin disorder"" supported by the sentence: ""[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].""?",False, -25968096,Hydrocortisone butyrate related to psoriasis,1152,Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.,"Is the triple ""Hydrocortisone butyrate related to psoriasis"" supported by the sentence: ""Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.""?",False, -17603464,Hydrocortisone butyrate disrupts psoriasis,1153,"Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.","Is the triple ""Hydrocortisone butyrate disrupts psoriasis"" supported by the sentence: ""Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.""?",False, -9729745,Adapalene related to acne,1154,The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.,"Is the triple ""Adapalene related to acne"" supported by the sentence: ""The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.""?",False, -8571018,Adapalene physically interacts with Retinoic Acid Receptor,1155,Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.,"Is the triple ""Adapalene physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.""?",False, -13523825,Retinol related to eye disorder,1156,"A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.","Is the triple ""Retinol related to eye disorder"" supported by the sentence: ""A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.""?",False, -11015290,Retinol related to tuberculosis,1157,[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].,"Is the triple ""Retinol related to tuberculosis"" supported by the sentence: ""[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].""?",False, -10457909,Retinol related to acne,1158,Vitamin A in acne vulgaris.,"Is the triple ""Retinol related to acne"" supported by the sentence: ""Vitamin A in acne vulgaris.""?",False, -8518043,Retinol related to malaria,1159,Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.,"Is the triple ""Retinol related to malaria"" supported by the sentence: ""Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.""?",False, -8137103,Retinol related to vitamin A deficiency,1160,"CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.","Is the triple ""Retinol related to vitamin A deficiency"" supported by the sentence: ""CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.""?",False, -7807614,Retinol related to retinitis pigmentosa,1161,"Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.","Is the triple ""Retinol related to retinitis pigmentosa"" supported by the sentence: ""Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.""?",False, -9304322,Retinol causes malaria,1162,"Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).","Is the triple ""Retinol causes malaria"" supported by the sentence: ""Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).""?",False, -27090494,Retinol affects diarrheal disease,1163,"However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.","Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.""?",False, -21959378,Retinol affects nutritional disorder,1164,Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.,"Is the triple ""Retinol affects nutritional disorder"" supported by the sentence: ""Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.""?",False, -17401879,Retinol affects tuberculosis,1165,"Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.","Is the triple ""Retinol affects tuberculosis"" supported by the sentence: ""Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.""?",False, -17082512,Retinol affects acne,1166,"Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.","Is the triple ""Retinol affects acne"" supported by the sentence: ""Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.""?",False, -12962972,Retinol affects eye disorder,1167,"The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.","Is the triple ""Retinol affects eye disorder"" supported by the sentence: ""The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.""?",False, -12534891,Retinol affects vitamin A deficiency,1168,The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.,"Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.""?",False, -11508263,Retinol affects diarrheal disease,1169,OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.,"Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.""?",False, -10941106,Retinol affects vitamin A deficiency,1170,"Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.","Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.""?",False, -22325993,Retinol produces Infection,1171,"As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).","Is the triple ""Retinol produces Infection"" supported by the sentence: ""As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).""?",False, -23772860,Retinol disrupts vitamin A deficiency,1172,"Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.","Is the triple ""Retinol disrupts vitamin A deficiency"" supported by the sentence: ""Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.""?",False, -12105339,Retinol disrupts diarrheal disease,1173,"Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.","Is the triple ""Retinol disrupts diarrheal disease"" supported by the sentence: ""Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.""?",False, -24823924,Retinol prevents Infection,1174,Vitamin A protects against infections and maintains epithelial integrity.,"Is the triple ""Retinol prevents Infection"" supported by the sentence: ""Vitamin A protects against infections and maintains epithelial integrity.""?",False, -17332605,Retinol prevents malaria,1175,CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.,"Is the triple ""Retinol prevents malaria"" supported by the sentence: ""CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.""?",False, -11445573,Retinol prevents nutritional disorder,1176,"Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.","Is the triple ""Retinol prevents nutritional disorder"" supported by the sentence: ""Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.""?",False, -8153477,Retinol prevents diarrheal disease,1177,"BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.","Is the triple ""Retinol prevents diarrheal disease"" supported by the sentence: ""BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.""?",False, -23860384,Retinol predisposes nutritional disorder,1178,"The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.","Is the triple ""Retinol predisposes nutritional disorder"" supported by the sentence: ""The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.""?",False, -19923430,Retinol predisposes malaria,1179,"We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.","Is the triple ""Retinol predisposes malaria"" supported by the sentence: ""We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.""?",False, -16391363,Retinol predisposes tuberculosis,1180,"A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.","Is the triple ""Retinol predisposes tuberculosis"" supported by the sentence: ""A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.""?",False, -15050082,Retinol predisposes diarrheal disease,1181,"Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.","Is the triple ""Retinol predisposes diarrheal disease"" supported by the sentence: ""Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.""?",False, -9744244,Retinol predisposes vitamin A deficiency,1182,"VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.","Is the triple ""Retinol predisposes vitamin A deficiency"" supported by the sentence: ""VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.""?",False, -18962170,Isotretinoin related to neuroblastoma,1183,We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.,"Is the triple ""Isotretinoin related to neuroblastoma"" supported by the sentence: ""We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.""?",False, -16229483,Isotretinoin related to brain cancer,1184,"Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.","Is the triple ""Isotretinoin related to brain cancer"" supported by the sentence: ""Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.""?",False, -15225681,Isotretinoin related to acne,1185,"The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.","Is the triple ""Isotretinoin related to acne"" supported by the sentence: ""The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.""?",False, -14091563,Isotretinoin related to myelodysplastic syndrome,1186,Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.,"Is the triple ""Isotretinoin related to myelodysplastic syndrome"" supported by the sentence: ""Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.""?",False, -9061344,Isotretinoin related to renal cell carcinoma,1187,BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).,"Is the triple ""Isotretinoin related to renal cell carcinoma"" supported by the sentence: ""BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).""?",False, -11768316,Isotretinoin physically interacts with Retinoic Acid Receptor,1188,"The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.","Is the triple ""Isotretinoin physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.""?",False, -21199868,Isotretinoin causes neuroblastoma,1189,"We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.","Is the triple ""Isotretinoin causes neuroblastoma"" supported by the sentence: ""We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.""?",False, -19803622,Isotretinoin causes acne,1190,Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.,"Is the triple ""Isotretinoin causes acne"" supported by the sentence: ""Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.""?",False, -19310397,Isotretinoin causes breast neoplasm,1191,Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.,"Is the triple ""Isotretinoin causes breast neoplasm"" supported by the sentence: ""Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.""?",False, -13522698,Isotretinoin causes neoplasm,1192,"We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.","Is the triple ""Isotretinoin causes neoplasm"" supported by the sentence: ""We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.""?",False, -23934527,Isotretinoin affects neoplasm,1193,"Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.""?",False, -20382078,Isotretinoin affects neuroblastoma,1194,"To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.","Is the triple ""Isotretinoin affects neuroblastoma"" supported by the sentence: ""To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.""?",False, -15927367,Isotretinoin affects rosacea,1195,"Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.","Is the triple ""Isotretinoin affects rosacea"" supported by the sentence: ""Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.""?",False, -15330626,Isotretinoin affects acne,1196,"In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.","Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.""?",False, -11212975,Isotretinoin affects neoplasm,1197,"CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.""?",False, -9764204,Isotretinoin affects acne,1198,Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.,"Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.""?",False, -21476432,Isotretinoin disrupts neuroblastoma,1199,Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.,"Is the triple ""Isotretinoin disrupts neuroblastoma"" supported by the sentence: ""Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.""?",False, -14724193,Isotretinoin disrupts neoplasm,1200,"Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.","Is the triple ""Isotretinoin disrupts neoplasm"" supported by the sentence: ""Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.""?",False, -14863864,Isotretinoin prevents acne,1201,"The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.","Is the triple ""Isotretinoin prevents acne"" supported by the sentence: ""The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.""?",False, -8312321,Isotretinoin prevents neoplasm,1202,Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.,"Is the triple ""Isotretinoin prevents neoplasm"" supported by the sentence: ""Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.""?",False, -15444114,Isotretinoin exacerbates ichthyosis,1203,We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.,"Is the triple ""Isotretinoin exacerbates ichthyosis"" supported by the sentence: ""We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.""?",False, -15310461,Isotretinoin predisposes acne,1204,"OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.","Is the triple ""Isotretinoin predisposes acne"" supported by the sentence: ""OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.""?",False, -24593446,Trifarotene affects acne,1205,The current review evaluates the role of trifarotene in treating acne.,"Is the triple ""Trifarotene affects acne"" supported by the sentence: ""The current review evaluates the role of trifarotene in treating acne.""?",False, -21448312,Atazanavir affects AIDS,1206,Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?,"Is the triple ""Atazanavir affects AIDS"" supported by the sentence: ""Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?""?",False, -24947472,Atazanavir disrupts HIV infectious disease,1207,"This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.","Is the triple ""Atazanavir disrupts HIV infectious disease"" supported by the sentence: ""This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.""?",False, -13198660,Atazanavir disrupts AIDS,1208,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Atazanavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, -20253995,Atazanavir prevents AIDS,1209,"Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.","Is the triple ""Atazanavir prevents AIDS"" supported by the sentence: ""Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.""?",False, -8134603,Saquinavir affects HIV infectious disease,1210,The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.,"Is the triple ""Saquinavir affects HIV infectious disease"" supported by the sentence: ""The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.""?",False, -16320598,Saquinavir disrupts viral infectious disease,1211,"SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.","Is the triple ""Saquinavir disrupts viral infectious disease"" supported by the sentence: ""SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.""?",False, -13198658,Saquinavir disrupts AIDS,1212,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Saquinavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, -17107608,Saquinavir prevents HIV infectious disease,1213,The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.,"Is the triple ""Saquinavir prevents HIV infectious disease"" supported by the sentence: ""The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.""?",False, -12560548,Indinavir prevents viral infectious disease,1214,Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.,"Is the triple ""Indinavir prevents viral infectious disease"" supported by the sentence: ""Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.""?",False, -15113750,Ritonavir related to AIDS,1215,Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.,"Is the triple ""Ritonavir related to AIDS"" supported by the sentence: ""Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.""?",False, -7566746,Ritonavir related to Cytochrome P-450 CYP3A,1216,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, -7566746,Ritonavir related to Cytochrome P-450 CYP3A,1217,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, -15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1218,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, -15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1219,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, -11500913,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1220,"In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).""?",False, -8329957,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1221,"Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.""?",False, -8452370,Ritonavir causes AIDS,1222,"Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.","Is the triple ""Ritonavir causes AIDS"" supported by the sentence: ""Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.""?",False, -21492333,Ritonavir affects neoplasm,1223,Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.,"Is the triple ""Ritonavir affects neoplasm"" supported by the sentence: ""Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.""?",False, -12140603,Ritonavir affects Insulin resistance,1224,"All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.","Is the triple ""Ritonavir affects Insulin resistance"" supported by the sentence: ""All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.""?",False, -9520105,Ritonavir affects HIV infectious disease,1225,This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.,"Is the triple ""Ritonavir affects HIV infectious disease"" supported by the sentence: ""This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.""?",False, -7566745,Ritonavir affects Cytochrome P-450 CYP3A,1226,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, -15873481,Ritonavir affects Cytochrome P-450 CYP3A,1227,"As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.""?",False, -21820102,Ritonavir disrupts Coronavinae infectious disease,1228,"Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.","Is the triple ""Ritonavir disrupts Coronavinae infectious disease"" supported by the sentence: ""Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.""?",False, -15656958,Ritonavir disrupts HIV infectious disease,1229,Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.,"Is the triple ""Ritonavir disrupts HIV infectious disease"" supported by the sentence: ""Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.""?",False, -9520113,Ritonavir disrupts neoplasm,1230,"In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.","Is the triple ""Ritonavir disrupts neoplasm"" supported by the sentence: ""In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.""?",False, -22737012,Ritonavir prevents neoplasm,1231,"Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.","Is the triple ""Ritonavir prevents neoplasm"" supported by the sentence: ""Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.""?",False, -10934319,Ritonavir prevents Kaposi's sarcoma,1232,The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.,"Is the triple ""Ritonavir prevents Kaposi's sarcoma"" supported by the sentence: ""The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.""?",False, -12915909,Nelfinavir causes diarrheal disease,1233,Does Roche's nelfinavir cause less diarrhea?,"Is the triple ""Nelfinavir causes diarrheal disease"" supported by the sentence: ""Does Roche's nelfinavir cause less diarrhea?""?",False, -19184628,Nelfinavir affects neoplasm,1234,"Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.","Is the triple ""Nelfinavir affects neoplasm"" supported by the sentence: ""Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.""?",False, -16087478,Nelfinavir affects plasma cell myeloma,1235,We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.,"Is the triple ""Nelfinavir affects plasma cell myeloma"" supported by the sentence: ""We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.""?",False, -11272488,Nelfinavir affects diarrheal disease,1236,"The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.","Is the triple ""Nelfinavir affects diarrheal disease"" supported by the sentence: ""The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.""?",False, -10940786,Thiopental affects brain injury,1237,"Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.","Is the triple ""Thiopental affects brain injury"" supported by the sentence: ""Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.""?",False, -7790675,Thiopental prevents brain injury,1238,"BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.","Is the triple ""Thiopental prevents brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.""?",False, -26262897,Pentobarbital causes insomnia,1239,The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.,"Is the triple ""Pentobarbital causes insomnia"" supported by the sentence: ""The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.""?",False, -25778415,Pentobarbital affects insomnia,1240,"Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""","Is the triple ""Pentobarbital affects insomnia"" supported by the sentence: ""Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""""?",False, -13642757,Pentobarbital disrupts status epilepticus,1241,"The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.","Is the triple ""Pentobarbital disrupts status epilepticus"" supported by the sentence: ""The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.""?",False, -23761012,Amobarbital prevents osteoarthritis,1242,"A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).","Is the triple ""Amobarbital prevents osteoarthritis"" supported by the sentence: ""A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).""?",False, -26983984,Moxisylyte causes erectile dysfunction,1243,"Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.","Is the triple ""Moxisylyte causes erectile dysfunction"" supported by the sentence: ""Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.""?",False, -26385811,Mepyramine prevents allergic disease,1244,Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).,"Is the triple ""Mepyramine prevents allergic disease"" supported by the sentence: ""Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).""?",False, -27140633,Promethazine subclass of Promethazine sulfoxide,1245,Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.,"Is the triple ""Promethazine subclass of Promethazine sulfoxide"" supported by the sentence: ""Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.""?",False, -19124534,Promethazine related to Vomiting,1246,"A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.","Is the triple ""Promethazine related to Vomiting"" supported by the sentence: ""A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.""?",False, -26252918,Promethazine causes Vomiting,1247,"Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.","Is the triple ""Promethazine causes Vomiting"" supported by the sentence: ""Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.""?",False, -8157500,Promethazine causes depressive disorder,1248,Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.,"Is the triple ""Promethazine causes depressive disorder"" supported by the sentence: ""Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.""?",False, -19547748,Promethazine affects Vomiting,1249,"The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).""?",False, -12404928,Promethazine affects Pruritus,1250,"Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.","Is the triple ""Promethazine affects Pruritus"" supported by the sentence: ""Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.""?",False, -10742218,Promethazine affects Nausea,1251,The effect of promethazine in nausea and vomiting of pregnancy.,"Is the triple ""Promethazine affects Nausea"" supported by the sentence: ""The effect of promethazine in nausea and vomiting of pregnancy.""?",False, -10228295,Promethazine affects central nervous system origin vertigo,1252,"We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.","Is the triple ""Promethazine affects central nervous system origin vertigo"" supported by the sentence: ""We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.""?",False, -7912966,Promethazine affects Vomiting,1253,"STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.""?",False, -13616931,Promethazine disrupts Nausea,1254,"Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).","Is the triple ""Promethazine disrupts Nausea"" supported by the sentence: ""Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).""?",False, -17497020,Promethazine prevents central nervous system origin vertigo,1255,OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.,"Is the triple ""Promethazine prevents central nervous system origin vertigo"" supported by the sentence: ""OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.""?",False, -11541778,Promethazine prevents Pruritus,1256,RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.,"Is the triple ""Promethazine prevents Pruritus"" supported by the sentence: ""RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.""?",False, -7912965,Promethazine prevents Vomiting,1257,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Vomiting"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, -7912964,Promethazine prevents Nausea,1258,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Nausea"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, -25750000,Clemastine causes urticaria,1259,"The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.","Is the triple ""Clemastine causes urticaria"" supported by the sentence: ""The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.""?",False, -25747466,Clemastine affects urticaria,1260,"The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.","Is the triple ""Clemastine affects urticaria"" supported by the sentence: ""The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.""?",False, -19433677,Clemastine affects Pruritus,1261,"The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.","Is the triple ""Clemastine affects Pruritus"" supported by the sentence: ""The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.""?",False, -25634655,Clemastine disrupts urticaria,1262,"Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.","Is the triple ""Clemastine disrupts urticaria"" supported by the sentence: ""Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.""?",False, -24612586,Clemastine prevents urticaria,1263,"An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.","Is the triple ""Clemastine prevents urticaria"" supported by the sentence: ""An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.""?",False, -17916924,Clemastine prevents dermatitis,1264,"The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.","Is the triple ""Clemastine prevents dermatitis"" supported by the sentence: ""The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.""?",False, -24699384,Clemastine predisposes allergic disease,1265,"To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.","Is the triple ""Clemastine predisposes allergic disease"" supported by the sentence: ""To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.""?",False, -25081855,Tiapride affects Dopamine D2 Receptor,1266,"Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.","Is the triple ""Tiapride affects Dopamine D2 Receptor"" supported by the sentence: ""Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.""?",False, -19553406,Amisulpride causes schizophrenia,1267,rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.,"Is the triple ""Amisulpride causes schizophrenia"" supported by the sentence: ""rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.""?",False, -9337142,Amisulpride causes psychotic disorder,1268,"Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.","Is the triple ""Amisulpride causes psychotic disorder"" supported by the sentence: ""Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.""?",False, -24415555,Amisulpride affects depressive disorder,1269,"The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.","Is the triple ""Amisulpride affects depressive disorder"" supported by the sentence: ""The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.""?",False, -8493076,Amisulpride affects schizophrenia,1270,"In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.","Is the triple ""Amisulpride affects schizophrenia"" supported by the sentence: ""In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.""?",False, -20532376,Amisulpride prevents Postoperative Nausea and Vomiting,1271,"Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.","Is the triple ""Amisulpride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.""?",False, -19821343,Amisulpride prevents Nausea,1272,Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.,"Is the triple ""Amisulpride prevents Nausea"" supported by the sentence: ""Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.""?",False, -11149280,Remoxipride physically interacts with Dopamine D2 Receptor,1273,Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.,"Is the triple ""Remoxipride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.""?",False, -9174370,Remoxipride affects Dopamine D2 Receptor,1274,Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.,"Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.""?",False, -24158881,Remoxipride affects Dopamine D2 Receptor,1275,"Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.","Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.""?",False, -20394421,Levosulpiride affects Dopamine D2 Receptor,1276,"Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.","Is the triple ""Levosulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.""?",False, -26880772,Nitroglycerin related to coronary artery disorder,1277,Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.,"Is the triple ""Nitroglycerin related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.""?",False, -26139329,Nitroglycerin related to hypertensive disorder,1278,A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.,"Is the triple ""Nitroglycerin related to hypertensive disorder"" supported by the sentence: ""A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.""?",False, -21173297,Nitroglycerin related to injury,1279,"Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.","Is the triple ""Nitroglycerin related to injury"" supported by the sentence: ""Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.""?",False, -26585664,Nitroglycerin causes Raynaud disease,1280,Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.,"Is the triple ""Nitroglycerin causes Raynaud disease"" supported by the sentence: ""Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.""?",False, -26278376,Nitroglycerin causes Angina pectoris,1281,Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.,"Is the triple ""Nitroglycerin causes Angina pectoris"" supported by the sentence: ""Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.""?",False, -26148974,Nitroglycerin causes myocardial infarction,1282,Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.,"Is the triple ""Nitroglycerin causes myocardial infarction"" supported by the sentence: ""Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.""?",False, -15949436,Nitroglycerin causes injury,1283,"If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.","Is the triple ""Nitroglycerin causes injury"" supported by the sentence: ""If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.""?",False, -15624022,Nitroglycerin causes Inflammation,1284,Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.,"Is the triple ""Nitroglycerin causes Inflammation"" supported by the sentence: ""Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.""?",False, -14985558,Nitroglycerin causes hypertensive disorder,1285,STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.,"Is the triple ""Nitroglycerin causes hypertensive disorder"" supported by the sentence: ""STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.""?",False, -8402702,Nitroglycerin causes Pain,1286,Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.,"Is the triple ""Nitroglycerin causes Pain"" supported by the sentence: ""Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.""?",False, -7629693,Nitroglycerin causes hypotensive disorder,1287,"In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.","Is the triple ""Nitroglycerin causes hypotensive disorder"" supported by the sentence: ""In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.""?",False, -26786108,Nitroglycerin affects coronary artery disorder,1288,Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.""?",False, -26278652,Nitroglycerin affects hypotensive disorder,1289,"This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.","Is the triple ""Nitroglycerin affects hypotensive disorder"" supported by the sentence: ""This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.""?",False, -25994904,Nitroglycerin affects Raynaud disease,1290,"The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.","Is the triple ""Nitroglycerin affects Raynaud disease"" supported by the sentence: ""The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.""?",False, -25747829,Nitroglycerin affects erectile dysfunction,1291,Impotence responsive to glyceryl trinitrate.,"Is the triple ""Nitroglycerin affects erectile dysfunction"" supported by the sentence: ""Impotence responsive to glyceryl trinitrate.""?",False, -25260538,Nitroglycerin affects Muscle spasm,1292,Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.,"Is the triple ""Nitroglycerin affects Muscle spasm"" supported by the sentence: ""Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.""?",False, -23178151,Nitroglycerin affects coronary artery disorder,1293,Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.""?",False, -20885558,Nitroglycerin affects injury,1294,Cardiac output effects of nitroglycerin in experimental lung injury.,"Is the triple ""Nitroglycerin affects injury"" supported by the sentence: ""Cardiac output effects of nitroglycerin in experimental lung injury.""?",False, -18491008,Nitroglycerin affects Hot flashes,1295,"After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).","Is the triple ""Nitroglycerin affects Hot flashes"" supported by the sentence: ""After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).""?",False, -14421188,Nitroglycerin affects Angina pectoris,1296,"Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).","Is the triple ""Nitroglycerin affects Angina pectoris"" supported by the sentence: ""Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).""?",False, -13478654,Nitroglycerin affects osteoporosis,1297,The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.,"Is the triple ""Nitroglycerin affects osteoporosis"" supported by the sentence: ""The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.""?",False, -11707783,Nitroglycerin affects Pain,1298,"We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.","Is the triple ""Nitroglycerin affects Pain"" supported by the sentence: ""We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.""?",False, -11174035,Nitroglycerin affects hypertensive disorder,1299,"The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.","Is the triple ""Nitroglycerin affects hypertensive disorder"" supported by the sentence: ""The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.""?",False, -10595566,Nitroglycerin affects stroke disorder,1300,[On the effect of nitroglycerin on the stroke- and minute volume of the heart].,"Is the triple ""Nitroglycerin affects stroke disorder"" supported by the sentence: ""[On the effect of nitroglycerin on the stroke- and minute volume of the heart].""?",False, -8601510,Nitroglycerin affects myocardial ischemia,1301,Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.,"Is the triple ""Nitroglycerin affects myocardial ischemia"" supported by the sentence: ""Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.""?",False, -8521770,Nitroglycerin affects phlebitis,1302,Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.,"Is the triple ""Nitroglycerin affects phlebitis"" supported by the sentence: ""Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.""?",False, -8049127,Nitroglycerin affects ischemia reperfusion injury,1303,Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.,"Is the triple ""Nitroglycerin affects ischemia reperfusion injury"" supported by the sentence: ""Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.""?",False, -26813951,Nitroglycerin disrupts myocardial ischemia,1304,Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.,"Is the triple ""Nitroglycerin disrupts myocardial ischemia"" supported by the sentence: ""Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.""?",False, -26590847,Nitroglycerin disrupts hypertensive disorder,1305,"CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.","Is the triple ""Nitroglycerin disrupts hypertensive disorder"" supported by the sentence: ""CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.""?",False, -24386334,Nitroglycerin disrupts phlebitis,1306,"The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).","Is the triple ""Nitroglycerin disrupts phlebitis"" supported by the sentence: ""The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).""?",False, -19274234,Nitroglycerin disrupts injury,1307,"Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.","Is the triple ""Nitroglycerin disrupts injury"" supported by the sentence: ""Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.""?",False, -10081147,Nitroglycerin disrupts Marchiafava-Bignami disease,1308,These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.,"Is the triple ""Nitroglycerin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.""?",False, -9796564,Nitroglycerin disrupts Pain,1309,At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.,"Is the triple ""Nitroglycerin disrupts Pain"" supported by the sentence: ""At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.""?",False, -25569906,Nitroglycerin prevents phlebitis,1310,CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.,"Is the triple ""Nitroglycerin prevents phlebitis"" supported by the sentence: ""CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.""?",False, -21983895,Nitroglycerin prevents Muscle spasm,1311,Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.,"Is the triple ""Nitroglycerin prevents Muscle spasm"" supported by the sentence: ""Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.""?",False, -20473117,Nitroglycerin prevents Inflammation,1312,Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.,"Is the triple ""Nitroglycerin prevents Inflammation"" supported by the sentence: ""Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.""?",False, -18491009,Nitroglycerin prevents Hot flashes,1313,CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.,"Is the triple ""Nitroglycerin prevents Hot flashes"" supported by the sentence: ""CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.""?",False, -17804368,Nitroglycerin prevents hypertensive disorder,1314,"Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.","Is the triple ""Nitroglycerin prevents hypertensive disorder"" supported by the sentence: ""Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.""?",False, -11496690,Nitroglycerin prevents ischemia reperfusion injury,1315,CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.,"Is the triple ""Nitroglycerin prevents ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.""?",False, -10695579,Nitroglycerin prevents Angina pectoris,1316,A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.,"Is the triple ""Nitroglycerin prevents Angina pectoris"" supported by the sentence: ""A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.""?",False, -10573276,Nitroglycerin prevents myocardial infarction,1317,Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.,"Is the triple ""Nitroglycerin prevents myocardial infarction"" supported by the sentence: ""Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.""?",False, -9096899,Nitroglycerin prevents Pain,1318,Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.,"Is the triple ""Nitroglycerin prevents Pain"" supported by the sentence: ""Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.""?",False, -9057729,Nitroglycerin prevents Shock,1319,"Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).","Is the triple ""Nitroglycerin prevents Shock"" supported by the sentence: ""Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).""?",False, -8235862,Nitroglycerin prevents Marchiafava-Bignami disease,1320,"Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).","Is the triple ""Nitroglycerin prevents Marchiafava-Bignami disease"" supported by the sentence: ""Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).""?",False, -7713034,Nitroglycerin prevents injury,1321,"It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.","Is the triple ""Nitroglycerin prevents injury"" supported by the sentence: ""It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.""?",False, -13750741,Nitroglycerin exacerbates myocardial ischemia,1322,"RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).","Is the triple ""Nitroglycerin exacerbates myocardial ischemia"" supported by the sentence: ""RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).""?",False, -20483551,Nitroglycerin predisposes myocardial ischemia,1323,OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.,"Is the triple ""Nitroglycerin predisposes myocardial ischemia"" supported by the sentence: ""OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.""?",False, -9897513,Nitroglycerin predisposes Angina pectoris,1324,Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.,"Is the triple ""Nitroglycerin predisposes Angina pectoris"" supported by the sentence: ""Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.""?",False, -20924645,Isosorbide dinitrate related to myocardial ischemia,1325,Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.,"Is the triple ""Isosorbide dinitrate related to myocardial ischemia"" supported by the sentence: ""Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.""?",False, -10616906,Isosorbide dinitrate related to Angina pectoris,1326,Isosorbide dinitrate in angina pectoris.,"Is the triple ""Isosorbide dinitrate related to Angina pectoris"" supported by the sentence: ""Isosorbide dinitrate in angina pectoris.""?",False, -9112334,Isosorbide dinitrate related to coronary artery disorder,1327,Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.,"Is the triple ""Isosorbide dinitrate related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.""?",False, -26334868,Isosorbide dinitrate affects Angina pectoris,1328,The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.,"Is the triple ""Isosorbide dinitrate affects Angina pectoris"" supported by the sentence: ""The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.""?",False, -10884689,Isosorbide dinitrate affects myocardial ischemia,1329,The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.,"Is the triple ""Isosorbide dinitrate affects myocardial ischemia"" supported by the sentence: ""The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.""?",False, -9112335,Isosorbide dinitrate prevents myocardial ischemia,1330,"To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.","Is the triple ""Isosorbide dinitrate prevents myocardial ischemia"" supported by the sentence: ""To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.""?",False, -17782283,Sulpiride physically interacts with Dopamine D2 Receptor,1331,"The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.""?",False, -7084056,Sulpiride physically interacts with Dopamine D2 Receptor,1332,"Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.""?",False, -25690684,Sulpiride causes depressive disorder,1333,"Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.","Is the triple ""Sulpiride causes depressive disorder"" supported by the sentence: ""Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.""?",False, -26343015,Sulpiride affects schizophrenia,1334,"On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.","Is the triple ""Sulpiride affects schizophrenia"" supported by the sentence: ""On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.""?",False, -23882267,Sulpiride affects anxiety,1335,Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.,"Is the triple ""Sulpiride affects anxiety"" supported by the sentence: ""Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.""?",False, -8960439,Sulpiride affects depressive disorder,1336,"This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.""?",False, -8364166,Sulpiride affects Dopamine D2 Receptor,1337,"Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.","Is the triple ""Sulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.""?",False, -7538297,Sulpiride affects depressive disorder,1338,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, -25756981,Sulpiride disrupts depressive disorder,1339,"(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.","Is the triple ""Sulpiride disrupts depressive disorder"" supported by the sentence: ""(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.""?",False, -8859505,Sulpiride disrupts anxiety,1340,"Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.","Is the triple ""Sulpiride disrupts anxiety"" supported by the sentence: ""Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.""?",False, -26753868,Isosorbide mononitrate causes Angina pectoris,1341,"To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.","Is the triple ""Isosorbide mononitrate causes Angina pectoris"" supported by the sentence: ""To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.""?",False, -15856723,Isosorbide mononitrate affects Angina pectoris,1342,Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.,"Is the triple ""Isosorbide mononitrate affects Angina pectoris"" supported by the sentence: ""Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.""?",False, -24979081,Isosorbide mononitrate prevents vascular disorder,1343,METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.,"Is the triple ""Isosorbide mononitrate prevents vascular disorder"" supported by the sentence: ""METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.""?",False, -22319748,Isosorbide mononitrate prevents Angina pectoris,1344,"Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.","Is the triple ""Isosorbide mononitrate prevents Angina pectoris"" supported by the sentence: ""Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.""?",False, -23203614,Ribociclib related to squamous cell carcinoma,1345,"Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.","Is the triple ""Ribociclib related to squamous cell carcinoma"" supported by the sentence: ""Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.""?",False, -23890460,Abemaciclib related to non-small cell lung carcinoma,1346,Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.,"Is the triple ""Abemaciclib related to non-small cell lung carcinoma"" supported by the sentence: ""Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.""?",False, -24133672,Abemaciclib affects neoplasm,1347,"We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.","Is the triple ""Abemaciclib affects neoplasm"" supported by the sentence: ""We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.""?",False, -23820208,Abemaciclib disrupts neoplasm,1348,Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.,"Is the triple ""Abemaciclib disrupts neoplasm"" supported by the sentence: ""Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.""?",False, -7114439,Sodium Chloride subclass of Electrolytes,1349,"LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.","Is the triple ""Sodium Chloride subclass of Electrolytes"" supported by the sentence: ""LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.""?",False, -27178225,Sodium Chloride related to hypoglycemia,1350,Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.,"Is the triple ""Sodium Chloride related to hypoglycemia"" supported by the sentence: ""Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.""?",False, -26906663,Sodium Chloride related to ventricular septal defect,1351,"When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).","Is the triple ""Sodium Chloride related to ventricular septal defect"" supported by the sentence: ""When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).""?",False, -26538206,Sodium Chloride related to papilloma,1352,The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.,"Is the triple ""Sodium Chloride related to papilloma"" supported by the sentence: ""The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.""?",False, -26529472,Sodium Chloride related to chronic obstructive pulmonary disease,1353,"Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.","Is the triple ""Sodium Chloride related to chronic obstructive pulmonary disease"" supported by the sentence: ""Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.""?",False, -26267091,Sodium Chloride related to Sepsis,1354,"The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.","Is the triple ""Sodium Chloride related to Sepsis"" supported by the sentence: ""The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.""?",False, -26209731,Sodium Chloride related to cataract,1355,Basic data supporting the use of the l-lysine salt of bendazac in cataract.,"Is the triple ""Sodium Chloride related to cataract"" supported by the sentence: ""Basic data supporting the use of the l-lysine salt of bendazac in cataract.""?",False, -25917183,Sodium Chloride related to Hypoxemia,1356,[Effect of vitamin C on water-salt metabolism in experimental hypoxia].,"Is the triple ""Sodium Chloride related to Hypoxemia"" supported by the sentence: ""[Effect of vitamin C on water-salt metabolism in experimental hypoxia].""?",False, -20673450,Sodium Chloride related to Alzheimer disease,1357,The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.,"Is the triple ""Sodium Chloride related to Alzheimer disease"" supported by the sentence: ""The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.""?",False, -20617514,Sodium Chloride related to type 2 diabetes mellitus,1358,"Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.","Is the triple ""Sodium Chloride related to type 2 diabetes mellitus"" supported by the sentence: ""Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.""?",False, -20321366,Sodium Chloride related to type 1 diabetes mellitus,1359,"In addition, NEN could impede the progression of DKD in T1D.","Is the triple ""Sodium Chloride related to type 1 diabetes mellitus"" supported by the sentence: ""In addition, NEN could impede the progression of DKD in T1D.""?",False, -19962817,Sodium Chloride related to Inflammation,1360,"These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.","Is the triple ""Sodium Chloride related to Inflammation"" supported by the sentence: ""These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.""?",False, -19891172,Sodium Chloride related to acute lung injury,1361,BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.,"Is the triple ""Sodium Chloride related to acute lung injury"" supported by the sentence: ""BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.""?",False, -19636264,Sodium Chloride related to ischemic disease,1362,"Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.","Is the triple ""Sodium Chloride related to ischemic disease"" supported by the sentence: ""Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.""?",False, -19577743,Sodium Chloride related to spinal cord injury,1363,OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.,"Is the triple ""Sodium Chloride related to spinal cord injury"" supported by the sentence: ""OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.""?",False, -19497082,Sodium Chloride related to primary ciliary dyskinesia,1364,A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.,"Is the triple ""Sodium Chloride related to primary ciliary dyskinesia"" supported by the sentence: ""A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.""?",False, -18975700,Sodium Chloride related to bacterial infectious disease,1365,Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.,"Is the triple ""Sodium Chloride related to bacterial infectious disease"" supported by the sentence: ""Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.""?",False, -18966398,Sodium Chloride related to osteoarthritis,1366,"CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.","Is the triple ""Sodium Chloride related to osteoarthritis"" supported by the sentence: ""CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.""?",False, -18860303,Sodium Chloride related to bone fracture,1367,Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).,"Is the triple ""Sodium Chloride related to bone fracture"" supported by the sentence: ""Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).""?",False, -18738706,Sodium Chloride related to toxic shock syndrome,1368,CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.,"Is the triple ""Sodium Chloride related to toxic shock syndrome"" supported by the sentence: ""CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.""?",False, -18679247,Sodium Chloride related to Electrolytes,1369,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, -18617363,Sodium Chloride related to iron deficiency anemia,1370,"At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.","Is the triple ""Sodium Chloride related to iron deficiency anemia"" supported by the sentence: ""At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.""?",False, -18287282,Sodium Chloride related to Pruritus,1371,"The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).","Is the triple ""Sodium Chloride related to Pruritus"" supported by the sentence: ""The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).""?",False, -17603340,Sodium Chloride related to brain injury,1372,Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.,"Is the triple ""Sodium Chloride related to brain injury"" supported by the sentence: ""Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.""?",False, -17533385,Sodium Chloride related to myocardial infarction,1373,Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.,"Is the triple ""Sodium Chloride related to myocardial infarction"" supported by the sentence: ""Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.""?",False, -17525035,Sodium Chloride related to coronary artery disorder,1374,The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.,"Is the triple ""Sodium Chloride related to coronary artery disorder"" supported by the sentence: ""The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.""?",False, -17213013,Sodium Chloride related to hepatocellular carcinoma,1375,"In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.","Is the triple ""Sodium Chloride related to hepatocellular carcinoma"" supported by the sentence: ""In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.""?",False, -17202845,Sodium Chloride related to Parkinson disease,1376,These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.,"Is the triple ""Sodium Chloride related to Parkinson disease"" supported by the sentence: ""These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.""?",False, -16886803,Sodium Chloride related to ischemia reperfusion injury,1377,Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.,"Is the triple ""Sodium Chloride related to ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.""?",False, -16594665,Sodium Chloride related to Pain,1378,"In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.","Is the triple ""Sodium Chloride related to Pain"" supported by the sentence: ""In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.""?",False, -16433967,Sodium Chloride related to liver and intrahepatic bile duct neoplasm,1379,Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.,"Is the triple ""Sodium Chloride related to liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.""?",False, -15412515,Sodium Chloride related to subarachnoid hemorrhage,1380,Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).,"Is the triple ""Sodium Chloride related to subarachnoid hemorrhage"" supported by the sentence: ""Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).""?",False, -14710472,Sodium Chloride related to bronchiolitis,1381,"High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.","Is the triple ""Sodium Chloride related to bronchiolitis"" supported by the sentence: ""High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.""?",False, -14037713,Sodium Chloride related to ventricular tachycardia,1382,"Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.","Is the triple ""Sodium Chloride related to ventricular tachycardia"" supported by the sentence: ""Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.""?",False, -13928740,Sodium Chloride related to pulmonary edema,1383,"Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.","Is the triple ""Sodium Chloride related to pulmonary edema"" supported by the sentence: ""Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.""?",False, -13375642,Sodium Chloride related to Insulin resistance,1384,"CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.","Is the triple ""Sodium Chloride related to Insulin resistance"" supported by the sentence: ""CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.""?",False, -13343201,Sodium Chloride related to Hypernatremia,1385,CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.,"Is the triple ""Sodium Chloride related to Hypernatremia"" supported by the sentence: ""CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.""?",False, -13277977,Sodium Chloride related to diabetic ketoacidosis,1386,The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.,"Is the triple ""Sodium Chloride related to diabetic ketoacidosis"" supported by the sentence: ""The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.""?",False, -11905993,Sodium Chloride related to depressive disorder,1387,"This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.","Is the triple ""Sodium Chloride related to depressive disorder"" supported by the sentence: ""This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.""?",False, -11014479,Sodium Chloride related to glaucoma,1388,[Dynamics of sodium chloride in the blood in glaucoma].,"Is the triple ""Sodium Chloride related to glaucoma"" supported by the sentence: ""[Dynamics of sodium chloride in the blood in glaucoma].""?",False, -10966302,Sodium Chloride related to malaria,1389,"Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.","Is the triple ""Sodium Chloride related to malaria"" supported by the sentence: ""Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.""?",False, -10739226,Sodium Chloride related to heart disorder,1390,[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].,"Is the triple ""Sodium Chloride related to heart disorder"" supported by the sentence: ""[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].""?",False, -10689901,Sodium Chloride related to diabetes mellitus,1391,[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].,"Is the triple ""Sodium Chloride related to diabetes mellitus"" supported by the sentence: ""[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].""?",False, -10566407,Sodium Chloride related to brain cancer,1392,[Water-salt and carbohydrate metabolism in brain tumors].,"Is the triple ""Sodium Chloride related to brain cancer"" supported by the sentence: ""[Water-salt and carbohydrate metabolism in brain tumors].""?",False, -10531148,Sodium Chloride related to kidney failure,1393,"[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].","Is the triple ""Sodium Chloride related to kidney failure"" supported by the sentence: ""[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].""?",False, -10510273,Sodium Chloride related to Shock,1394,[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].,"Is the triple ""Sodium Chloride related to Shock"" supported by the sentence: ""[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].""?",False, -10504585,Sodium Chloride related to tuberculosis,1395,[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].,"Is the triple ""Sodium Chloride related to tuberculosis"" supported by the sentence: ""[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].""?",False, -10502982,Sodium Chloride related to nutritional disorder,1396,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to nutritional disorder"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, -10502981,Sodium Chloride related to cirrhosis of liver,1397,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to cirrhosis of liver"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, -10487095,Sodium Chloride related to pneumonia,1398,[Water and salt content in the lung in vagus pneumonia].,"Is the triple ""Sodium Chloride related to pneumonia"" supported by the sentence: ""[Water and salt content in the lung in vagus pneumonia].""?",False, -10439781,Sodium Chloride related to acute kidney failure,1399,Patterns of renal salt loss in acute renal failure.,"Is the triple ""Sodium Chloride related to acute kidney failure"" supported by the sentence: ""Patterns of renal salt loss in acute renal failure.""?",False, -10433628,Sodium Chloride related to psoriasis,1400,[Studies on water and salt metabolism in psoriasis].,"Is the triple ""Sodium Chloride related to psoriasis"" supported by the sentence: ""[Studies on water and salt metabolism in psoriasis].""?",False, -10370762,Sodium Chloride related to Hypothermia,1401,[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].,"Is the triple ""Sodium Chloride related to Hypothermia"" supported by the sentence: ""[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].""?",False, -10318383,Sodium Chloride related to cardiovascular disorder,1402,Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.,"Is the triple ""Sodium Chloride related to cardiovascular disorder"" supported by the sentence: ""Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.""?",False, -10300324,Sodium Chloride related to stroke disorder,1403,"Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).","Is the triple ""Sodium Chloride related to stroke disorder"" supported by the sentence: ""Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).""?",False, -10268953,Sodium Chloride related to brain edema,1404,"The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.","Is the triple ""Sodium Chloride related to brain edema"" supported by the sentence: ""The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.""?",False, -9985623,Sodium Chloride related to Nausea,1405,"Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.","Is the triple ""Sodium Chloride related to Nausea"" supported by the sentence: ""Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.""?",False, -9642141,Sodium Chloride related to obesity disorder,1406,"The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).","Is the triple ""Sodium Chloride related to obesity disorder"" supported by the sentence: ""The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).""?",False, -9504754,Sodium Chloride related to asthma,1407,Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.,"Is the triple ""Sodium Chloride related to asthma"" supported by the sentence: ""Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.""?",False, -9350794,Sodium Chloride related to essential hypertension,1408,[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].,"Is the triple ""Sodium Chloride related to essential hypertension"" supported by the sentence: ""[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].""?",False, -9217528,Sodium Chloride related to dry eye syndrome,1409,The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.,"Is the triple ""Sodium Chloride related to dry eye syndrome"" supported by the sentence: ""The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.""?",False, -8489872,Sodium Chloride related to injury,1410,Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.,"Is the triple ""Sodium Chloride related to injury"" supported by the sentence: ""Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.""?",False, -8486278,Sodium Chloride related to cystic fibrosis,1411,"We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.","Is the triple ""Sodium Chloride related to cystic fibrosis"" supported by the sentence: ""We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.""?",False, -7822303,Sodium Chloride related to neoplasm,1412,"Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.","Is the triple ""Sodium Chloride related to neoplasm"" supported by the sentence: ""Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.""?",False, -7455347,Sodium Chloride related to Hypovolemia,1413,"It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.","Is the triple ""Sodium Chloride related to Hypovolemia"" supported by the sentence: ""It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.""?",False, -7397406,Sodium Chloride related to kidney disorder,1414,Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.,"Is the triple ""Sodium Chloride related to kidney disorder"" supported by the sentence: ""Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.""?",False, -7259411,Sodium Chloride related to hypertensive disorder,1415,"Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.","Is the triple ""Sodium Chloride related to hypertensive disorder"" supported by the sentence: ""Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.""?",False, -19769676,Sodium Chloride related to Electrolytes,1416,"Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.","Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.""?",False, -18679248,Sodium Chloride close match Electrolytes,1417,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride close match Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, -7792933,Sodium Chloride coexists with Electrolytes,1418,"Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).","Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).""?",False, -9181325,Sodium Chloride coexists with Electrolytes,1419,Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.,"Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.""?",False, -27223278,Sodium Chloride derives from Electrolytes,1420,The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.,"Is the triple ""Sodium Chloride derives from Electrolytes"" supported by the sentence: ""The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.""?",False, -9585905,Sodium Chloride physically interacts with Electrolytes,1421,"The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.""?",False, -9585904,Sodium Chloride physically interacts with Electrolytes,1422,"The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.""?",False, -26947391,Sodium Chloride causes acute kidney tubular necrosis,1423,"Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).","Is the triple ""Sodium Chloride causes acute kidney tubular necrosis"" supported by the sentence: ""Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).""?",False, -26813055,Sodium Chloride causes Dyspnea,1424,"When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.","Is the triple ""Sodium Chloride causes Dyspnea"" supported by the sentence: ""When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.""?",False, -26651944,Sodium Chloride causes severe cutaneous adverse reaction,1425,In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.,"Is the triple ""Sodium Chloride causes severe cutaneous adverse reaction"" supported by the sentence: ""In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.""?",False, -26200221,Sodium Chloride causes melanoma,1426,In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.,"Is the triple ""Sodium Chloride causes melanoma"" supported by the sentence: ""In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.""?",False, -25963723,Sodium Chloride causes cardiac arrest,1427,Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.,"Is the triple ""Sodium Chloride causes cardiac arrest"" supported by the sentence: ""Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.""?",False, -24999522,Sodium Chloride causes Nausea,1428,"In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.","Is the triple ""Sodium Chloride causes Nausea"" supported by the sentence: ""In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.""?",False, -23507574,Sodium Chloride causes burn,1429,"The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.","Is the triple ""Sodium Chloride causes burn"" supported by the sentence: ""The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.""?",False, -21365055,Sodium Chloride causes respiratory failure,1430,Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.,"Is the triple ""Sodium Chloride causes respiratory failure"" supported by the sentence: ""Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.""?",False, -20716492,Sodium Chloride causes multiple organ dysfunction syndrome,1431,"Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.","Is the triple ""Sodium Chloride causes multiple organ dysfunction syndrome"" supported by the sentence: ""Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.""?",False, -20666627,Sodium Chloride causes malaria,1432,"During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.","Is the triple ""Sodium Chloride causes malaria"" supported by the sentence: ""During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.""?",False, -20168868,Sodium Chloride causes fibromyalgia,1433,"Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.","Is the triple ""Sodium Chloride causes fibromyalgia"" supported by the sentence: ""Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.""?",False, -19652731,Sodium Chloride causes Chronic pain,1434,"METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.","Is the triple ""Sodium Chloride causes Chronic pain"" supported by the sentence: ""METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.""?",False, -19581650,Sodium Chloride causes neoplasm,1435,"NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.","Is the triple ""Sodium Chloride causes neoplasm"" supported by the sentence: ""NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.""?",False, -19527177,Sodium Chloride causes liver and intrahepatic bile duct neoplasm,1436,"Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.","Is the triple ""Sodium Chloride causes liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.""?",False, -19434783,Sodium Chloride causes Low back pain,1437,"METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).","Is the triple ""Sodium Chloride causes Low back pain"" supported by the sentence: ""METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).""?",False, -19352698,Sodium Chloride causes bone fracture,1438,"Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.","Is the triple ""Sodium Chloride causes bone fracture"" supported by the sentence: ""Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.""?",False, -19268574,Sodium Chloride causes ulcerative colitis,1439,"Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.","Is the triple ""Sodium Chloride causes ulcerative colitis"" supported by the sentence: ""Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.""?",False, -18873789,Sodium Chloride causes preeclampsia,1440,This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.,"Is the triple ""Sodium Chloride causes preeclampsia"" supported by the sentence: ""This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.""?",False, -18760766,Sodium Chloride causes heart disorder,1441,"Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.","Is the triple ""Sodium Chloride causes heart disorder"" supported by the sentence: ""Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.""?",False, -18419412,Sodium Chloride causes infertility disorder,1442,"The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.","Is the triple ""Sodium Chloride causes infertility disorder"" supported by the sentence: ""The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.""?",False, -18184755,Sodium Chloride causes intervertebral disc degenerative disorder,1443,"Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.","Is the triple ""Sodium Chloride causes intervertebral disc degenerative disorder"" supported by the sentence: ""Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.""?",False, -18174270,Sodium Chloride causes asthma,1444,"We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.","Is the triple ""Sodium Chloride causes asthma"" supported by the sentence: ""We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.""?",False, -17957169,Sodium Chloride causes subarachnoid hemorrhage,1445,Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.,"Is the triple ""Sodium Chloride causes subarachnoid hemorrhage"" supported by the sentence: ""Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.""?",False, -17846702,Sodium Chloride causes cardiovascular disorder,1446,"Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.","Is the triple ""Sodium Chloride causes cardiovascular disorder"" supported by the sentence: ""Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.""?",False, -17472790,Sodium Chloride causes Postoperative Complications,1447,"BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.","Is the triple ""Sodium Chloride causes Postoperative Complications"" supported by the sentence: ""BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.""?",False, -17050802,Sodium Chloride causes pulmonary arterial hypertension,1448,Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.,"Is the triple ""Sodium Chloride causes pulmonary arterial hypertension"" supported by the sentence: ""Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.""?",False, -16922792,Sodium Chloride causes aortic aneurysm,1449,"CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.","Is the triple ""Sodium Chloride causes aortic aneurysm"" supported by the sentence: ""CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.""?",False, -16902385,Sodium Chloride causes Hypoxemia,1450,The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.,"Is the triple ""Sodium Chloride causes Hypoxemia"" supported by the sentence: ""The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.""?",False, -16884655,Sodium Chloride causes obesity disorder,1451,[Promoting obesity with the salt shaker. How too much salt causes obesity in children].,"Is the triple ""Sodium Chloride causes obesity disorder"" supported by the sentence: ""[Promoting obesity with the salt shaker. How too much salt causes obesity in children].""?",False, -15862216,Sodium Chloride causes Sepsis,1452,"In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.","Is the triple ""Sodium Chloride causes Sepsis"" supported by the sentence: ""In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.""?",False, -15183436,Sodium Chloride causes cardiac rhythm disease,1453,"CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""","Is the triple ""Sodium Chloride causes cardiac rhythm disease"" supported by the sentence: ""CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""""?",False, -14507617,Sodium Chloride causes brain edema,1454,"The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.","Is the triple ""Sodium Chloride causes brain edema"" supported by the sentence: ""The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.""?",False, -14335740,Sodium Chloride causes essential hypertension,1455,"Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.","Is the triple ""Sodium Chloride causes essential hypertension"" supported by the sentence: ""Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.""?",False, -14100671,Sodium Chloride causes Cough,1456,"Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.","Is the triple ""Sodium Chloride causes Cough"" supported by the sentence: ""Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.""?",False, -13899816,Sodium Chloride causes brain injury,1457,BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.,"Is the triple ""Sodium Chloride causes brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.""?",False, -13415978,Sodium Chloride causes rhinitis,1458,Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).,"Is the triple ""Sodium Chloride causes rhinitis"" supported by the sentence: ""Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).""?",False, -13156241,Sodium Chloride causes allergic disease,1459,"The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.","Is the triple ""Sodium Chloride causes allergic disease"" supported by the sentence: ""The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.""?",False, -12922926,Sodium Chloride causes periodontitis,1460,"Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.","Is the triple ""Sodium Chloride causes periodontitis"" supported by the sentence: ""Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.""?",False, -12796728,Sodium Chloride causes myocardial infarction,1461,"Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.","Is the triple ""Sodium Chloride causes myocardial infarction"" supported by the sentence: ""Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.""?",False, -12757253,Sodium Chloride causes urticaria,1462,"If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.","Is the triple ""Sodium Chloride causes urticaria"" supported by the sentence: ""If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.""?",False, -12052924,Sodium Chloride causes Fever,1463,"Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.","Is the triple ""Sodium Chloride causes Fever"" supported by the sentence: ""Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.""?",False, -11367442,Sodium Chloride causes Hypothermia,1464,"In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.","Is the triple ""Sodium Chloride causes Hypothermia"" supported by the sentence: ""In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.""?",False, -10844905,Sodium Chloride causes kidney disorder,1465,These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.,"Is the triple ""Sodium Chloride causes kidney disorder"" supported by the sentence: ""These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.""?",False, -10703852,Sodium Chloride causes Ascites,1466,Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.,"Is the triple ""Sodium Chloride causes Ascites"" supported by the sentence: ""Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.""?",False, -10680402,Sodium Chloride causes kidney failure,1467,[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].,"Is the triple ""Sodium Chloride causes kidney failure"" supported by the sentence: ""[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].""?",False, -10468869,Sodium Chloride causes Hyperhidrosis,1468,The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.,"Is the triple ""Sodium Chloride causes Hyperhidrosis"" supported by the sentence: ""The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.""?",False, -10303736,Sodium Chloride causes Hemorrhage,1469,Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.,"Is the triple ""Sodium Chloride causes Hemorrhage"" supported by the sentence: ""Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.""?",False, -10216492,Sodium Chloride causes Insulin resistance,1470,"What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.","Is the triple ""Sodium Chloride causes Insulin resistance"" supported by the sentence: ""What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.""?",False, -9649854,Sodium Chloride causes Inflammation,1471,Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.,"Is the triple ""Sodium Chloride causes Inflammation"" supported by the sentence: ""Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.""?",False, -9417058,Sodium Chloride causes stroke disorder,1472,"The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.","Is the triple ""Sodium Chloride causes stroke disorder"" supported by the sentence: ""The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.""?",False, -9370401,Sodium Chloride causes acute kidney failure,1473,"RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.","Is the triple ""Sodium Chloride causes acute kidney failure"" supported by the sentence: ""RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.""?",False, -9311776,Sodium Chloride causes hypotensive disorder,1474,Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.,"Is the triple ""Sodium Chloride causes hypotensive disorder"" supported by the sentence: ""Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.""?",False, -8912328,Sodium Chloride causes injury,1475,"Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.","Is the triple ""Sodium Chloride causes injury"" supported by the sentence: ""Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.""?",False, -8760965,Sodium Chloride causes hyperinsulinism,1476,"Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).","Is the triple ""Sodium Chloride causes hyperinsulinism"" supported by the sentence: ""Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).""?",False, -8723767,Sodium Chloride causes Hyponatremia,1477,"The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.","Is the triple ""Sodium Chloride causes Hyponatremia"" supported by the sentence: ""The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.""?",False, -8658207,Sodium Chloride causes ischemic disease,1478,"Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.","Is the triple ""Sodium Chloride causes ischemic disease"" supported by the sentence: ""Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.""?",False, -8215909,Sodium Chloride causes type 2 diabetes mellitus,1479,"The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.","Is the triple ""Sodium Chloride causes type 2 diabetes mellitus"" supported by the sentence: ""The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.""?",False, -7966995,Sodium Chloride causes Shock,1480,"In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.","Is the triple ""Sodium Chloride causes Shock"" supported by the sentence: ""In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.""?",False, -7871886,Sodium Chloride causes Hypernatremia,1481,"Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').","Is the triple ""Sodium Chloride causes Hypernatremia"" supported by the sentence: ""Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').""?",False, -7769838,Sodium Chloride causes Pain,1482,The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.,"Is the triple ""Sodium Chloride causes Pain"" supported by the sentence: ""The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.""?",False, -7535626,Sodium Chloride causes pulmonary edema,1483,"The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.","Is the triple ""Sodium Chloride causes pulmonary edema"" supported by the sentence: ""The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.""?",False, -7170398,Sodium Chloride causes cataract,1484,"Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.","Is the triple ""Sodium Chloride causes cataract"" supported by the sentence: ""Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.""?",False, -7067270,Sodium Chloride causes hypertensive disorder,1485,"The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.","Is the triple ""Sodium Chloride causes hypertensive disorder"" supported by the sentence: ""The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.""?",False, -27640062,Sodium Chloride affects hyperinsulinism,1486,Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.,"Is the triple ""Sodium Chloride affects hyperinsulinism"" supported by the sentence: ""Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.""?",False, -27459630,Sodium Chloride affects ischemic disease,1487,"In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.","Is the triple ""Sodium Chloride affects ischemic disease"" supported by the sentence: ""In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.""?",False, -26883243,Sodium Chloride affects pulmonary edema,1488,"The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.","Is the triple ""Sodium Chloride affects pulmonary edema"" supported by the sentence: ""The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.""?",False, -25873721,Sodium Chloride affects stroke disorder,1489,Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].,"Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].""?",False, -25698961,Sodium Chloride affects Hypovolemia,1490,"However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.","Is the triple ""Sodium Chloride affects Hypovolemia"" supported by the sentence: ""However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.""?",False, -23350231,Sodium Chloride affects allergic disease,1491,"Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.""?",False, -21279163,Sodium Chloride affects Postoperative Nausea and Vomiting,1492,Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride affects Postoperative Nausea and Vomiting"" supported by the sentence: ""Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.""?",False, -19916489,Sodium Chloride affects malaria,1493,"The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.""?",False, -19654566,Sodium Chloride affects Fever,1494,The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.,"Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.""?",False, -19387644,Sodium Chloride affects Dyspnea,1495,The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.,"Is the triple ""Sodium Chloride affects Dyspnea"" supported by the sentence: ""The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.""?",False, -19198162,Sodium Chloride affects Hyperhidrosis,1496,"ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.""?",False, -19068195,Sodium Chloride affects Pain,1497,RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.,"Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.""?",False, -18857149,Sodium Chloride affects injury,1498,We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.""?",False, -18063112,Sodium Chloride affects myocardial infarction,1499,Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.,"Is the triple ""Sodium Chloride affects myocardial infarction"" supported by the sentence: ""Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.""?",False, -17981225,Sodium Chloride affects Fever,1500,"The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.""?",False, -17956116,Sodium Chloride affects Hyponatremia,1501,Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.,"Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.""?",False, -17749046,Sodium Chloride affects asthma,1502,The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.""?",False, -17453252,Sodium Chloride affects Hyperhidrosis,1503,"The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.""?",False, -17320603,Sodium Chloride affects brain injury,1504,"STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.""?",False, -17252322,Sodium Chloride affects iron deficiency anemia,1505,"At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.","Is the triple ""Sodium Chloride affects iron deficiency anemia"" supported by the sentence: ""At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.""?",False, -17081119,Sodium Chloride affects cataract,1506,PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride affects cataract"" supported by the sentence: ""PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.""?",False, -17021361,Sodium Chloride affects urticaria,1507,"CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.","Is the triple ""Sodium Chloride affects urticaria"" supported by the sentence: ""CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.""?",False, -16829226,Sodium Chloride affects osteoarthritis,1508,"The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.","Is the triple ""Sodium Chloride affects osteoarthritis"" supported by the sentence: ""The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.""?",False, -16392979,Sodium Chloride affects Sepsis,1509,Effects of hydrogen-rich saline treatment on polymicrobial sepsis.,"Is the triple ""Sodium Chloride affects Sepsis"" supported by the sentence: ""Effects of hydrogen-rich saline treatment on polymicrobial sepsis.""?",False, -16339812,Sodium Chloride affects Inflammation,1510,OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.,"Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.""?",False, -16191401,Sodium Chloride affects Shock,1511,"When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.","Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.""?",False, -16150899,Sodium Chloride affects severe cutaneous adverse reaction,1512,Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.,"Is the triple ""Sodium Chloride affects severe cutaneous adverse reaction"" supported by the sentence: ""Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.""?",False, -15784044,Sodium Chloride affects Electrolytes,1513,From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.,"Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.""?",False, -15684126,Sodium Chloride affects malaria,1514,"Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.""?",False, -15518572,Sodium Chloride affects ischemia reperfusion injury,1515,This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.,"Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.""?",False, -15358630,Sodium Chloride affects brain injury,1516,"Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.""?",False, -14974493,Sodium Chloride affects cardiovascular disorder,1517,"OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.","Is the triple ""Sodium Chloride affects cardiovascular disorder"" supported by the sentence: ""OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.""?",False, -14875621,Sodium Chloride affects Hypoxemia,1518,"CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.","Is the triple ""Sodium Chloride affects Hypoxemia"" supported by the sentence: ""CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.""?",False, -14652078,Sodium Chloride affects preeclampsia,1519,Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.,"Is the triple ""Sodium Chloride affects preeclampsia"" supported by the sentence: ""Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.""?",False, -14650670,Sodium Chloride affects Ascites,1520,In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.""?",False, -14454543,Sodium Chloride affects Inflammation,1521,"Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.","Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.""?",False, -14269847,Sodium Chloride affects kidney disorder,1522,"Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.","Is the triple ""Sodium Chloride affects kidney disorder"" supported by the sentence: ""Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.""?",False, -13713189,Sodium Chloride affects acute lung injury,1523,Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.,"Is the triple ""Sodium Chloride affects acute lung injury"" supported by the sentence: ""Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.""?",False, -13361928,Sodium Chloride affects cardiac rhythm disease,1524,"This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.","Is the triple ""Sodium Chloride affects cardiac rhythm disease"" supported by the sentence: ""This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.""?",False, -13091031,Sodium Chloride affects ischemia reperfusion injury,1525,"Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.","Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.""?",False, -12113298,Sodium Chloride affects diabetes mellitus,1526,"The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.","Is the triple ""Sodium Chloride affects diabetes mellitus"" supported by the sentence: ""The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.""?",False, -11936868,Sodium Chloride affects allergic disease,1527,"In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.""?",False, -11761266,Sodium Chloride affects stroke disorder,1528,"CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.","Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.""?",False, -11373059,Sodium Chloride affects Pain,1529,"In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.","Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.""?",False, -11352407,Sodium Chloride affects hypotensive disorder,1530,"Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.","Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.""?",False, -10762234,Sodium Chloride affects hypotensive disorder,1531,[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].,"Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].""?",False, -10689150,Sodium Chloride affects Hemorrhage,1532,"The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).""?",False, -10555492,Sodium Chloride affects nutritional disorder,1533,[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].,"Is the triple ""Sodium Chloride affects nutritional disorder"" supported by the sentence: ""[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].""?",False, -10543207,Sodium Chloride affects myocarditis,1534,"Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.","Is the triple ""Sodium Chloride affects myocarditis"" supported by the sentence: ""Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.""?",False, -10409590,Sodium Chloride affects essential hypertension,1535,"The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.","Is the triple ""Sodium Chloride affects essential hypertension"" supported by the sentence: ""The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.""?",False, -10373089,Sodium Chloride affects Hypernatremia,1536,"Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.","Is the triple ""Sodium Chloride affects Hypernatremia"" supported by the sentence: ""Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.""?",False, -10347664,Sodium Chloride affects neoplasm,1537,"However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.","Is the triple ""Sodium Chloride affects neoplasm"" supported by the sentence: ""However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.""?",False, -10303742,Sodium Chloride affects Hemorrhage,1538,"In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.""?",False, -10216887,Sodium Chloride affects Shock,1539,Refolding of a high molecular weight protein: salt effect on collapse.,"Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""Refolding of a high molecular weight protein: salt effect on collapse.""?",False, -10038950,Sodium Chloride affects injury,1540,This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.""?",False, -9833746,Sodium Chloride affects obesity disorder,1541,"Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.","Is the triple ""Sodium Chloride affects obesity disorder"" supported by the sentence: ""Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.""?",False, -9701968,Sodium Chloride affects brain edema,1542,The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.,"Is the triple ""Sodium Chloride affects brain edema"" supported by the sentence: ""The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.""?",False, -9235049,Sodium Chloride affects Hyponatremia,1543,"Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.","Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.""?",False, -9211629,Sodium Chloride affects asthma,1544,OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.""?",False, -8885675,Sodium Chloride affects Ascites,1545,The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.""?",False, -8142503,Sodium Chloride affects Insulin resistance,1546,"These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.","Is the triple ""Sodium Chloride affects Insulin resistance"" supported by the sentence: ""These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.""?",False, -7538296,Sodium Chloride affects depressive disorder,1547,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, -7487288,Sodium Chloride affects Hemorrhage,1548,Epinephrine in bupivacaine or saline reduced peroperative bleeding.,"Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""Epinephrine in bupivacaine or saline reduced peroperative bleeding.""?",False, -7249676,Sodium Chloride affects Fever,1549,"By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.""?",False, -7189372,Sodium Chloride affects depressive disorder,1550,"Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.""?",False, -7186849,Sodium Chloride affects hypertensive disorder,1551,"Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.","Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.""?",False, -7146026,Sodium Chloride affects hypertensive disorder,1552,This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.,"Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.""?",False, -10370500,Sodium Chloride affects Electrolytes,1553,"As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.","Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.""?",False, -14010559,Sodium Chloride produces hypertensive disorder,1554,Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.,"Is the triple ""Sodium Chloride produces hypertensive disorder"" supported by the sentence: ""Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.""?",False, -25864505,Sodium Chloride disrupts malaria,1555,A trial of chloroquine-medicated salt for malaria suppression in Uganda.,"Is the triple ""Sodium Chloride disrupts malaria"" supported by the sentence: ""A trial of chloroquine-medicated salt for malaria suppression in Uganda.""?",False, -19817939,Sodium Chloride disrupts chronic obstructive pulmonary disease,1556,Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.,"Is the triple ""Sodium Chloride disrupts chronic obstructive pulmonary disease"" supported by the sentence: ""Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.""?",False, -19569177,Sodium Chloride disrupts anxiety,1557,Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.,"Is the triple ""Sodium Chloride disrupts anxiety"" supported by the sentence: ""Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.""?",False, -19347835,Sodium Chloride disrupts cardiac rhythm disease,1558,Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.,"Is the triple ""Sodium Chloride disrupts cardiac rhythm disease"" supported by the sentence: ""Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.""?",False, -19339201,Sodium Chloride disrupts Cough,1559,"On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.","Is the triple ""Sodium Chloride disrupts Cough"" supported by the sentence: ""On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.""?",False, -18711875,Sodium Chloride disrupts pulmonary edema,1560,"Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.","Is the triple ""Sodium Chloride disrupts pulmonary edema"" supported by the sentence: ""Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.""?",False, -18638520,Sodium Chloride disrupts brain edema,1561,TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.,"Is the triple ""Sodium Chloride disrupts brain edema"" supported by the sentence: ""TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.""?",False, -18394970,Sodium Chloride disrupts Inflammation,1562,"In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.","Is the triple ""Sodium Chloride disrupts Inflammation"" supported by the sentence: ""In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.""?",False, -17319016,Sodium Chloride disrupts dental caries,1563,"Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.","Is the triple ""Sodium Chloride disrupts dental caries"" supported by the sentence: ""Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.""?",False, -17223012,Sodium Chloride disrupts hypertensive disorder,1564,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts hypertensive disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, -17223011,Sodium Chloride disrupts cardiovascular disorder,1565,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts cardiovascular disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, -17009512,Sodium Chloride disrupts allergic disease,1566,"Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.","Is the triple ""Sodium Chloride disrupts allergic disease"" supported by the sentence: ""Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.""?",False, -13585452,Sodium Chloride disrupts neoplasm,1567,"Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.","Is the triple ""Sodium Chloride disrupts neoplasm"" supported by the sentence: ""Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.""?",False, -12586414,Sodium Chloride disrupts Hypoxemia,1568,"Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.","Is the triple ""Sodium Chloride disrupts Hypoxemia"" supported by the sentence: ""Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.""?",False, -12214170,Sodium Chloride disrupts injury,1569,"Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.","Is the triple ""Sodium Chloride disrupts injury"" supported by the sentence: ""Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.""?",False, -10927798,Sodium Chloride disrupts stroke disorder,1570,"The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.","Is the triple ""Sodium Chloride disrupts stroke disorder"" supported by the sentence: ""The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.""?",False, -8273399,Sodium Chloride disrupts Pain,1571,Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.,"Is the triple ""Sodium Chloride disrupts Pain"" supported by the sentence: ""Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.""?",False, -27207716,Sodium Chloride prevents periodontal disorder,1572,"Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.","Is the triple ""Sodium Chloride prevents periodontal disorder"" supported by the sentence: ""Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.""?",False, -27075073,Sodium Chloride prevents subarachnoid hemorrhage,1573,"The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.","Is the triple ""Sodium Chloride prevents subarachnoid hemorrhage"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.""?",False, -23771600,Sodium Chloride prevents sinusitis,1574,Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.,"Is the triple ""Sodium Chloride prevents sinusitis"" supported by the sentence: ""Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.""?",False, -21279166,Sodium Chloride prevents Postoperative Nausea and Vomiting,1575,Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.""?",False, -20586429,Sodium Chloride prevents stroke disorder,1576,"In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).","Is the triple ""Sodium Chloride prevents stroke disorder"" supported by the sentence: ""In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).""?",False, -20472317,Sodium Chloride prevents myocardial infarction,1577,This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.,"Is the triple ""Sodium Chloride prevents myocardial infarction"" supported by the sentence: ""This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.""?",False, -20150308,Sodium Chloride prevents Chronic pain,1578,"Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.","Is the triple ""Sodium Chloride prevents Chronic pain"" supported by the sentence: ""Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.""?",False, -20050861,Sodium Chloride prevents Dyspnea,1579,DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.,"Is the triple ""Sodium Chloride prevents Dyspnea"" supported by the sentence: ""DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.""?",False, -19622277,Sodium Chloride prevents Pruritus,1580,"IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).","Is the triple ""Sodium Chloride prevents Pruritus"" supported by the sentence: ""IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).""?",False, -19347836,Sodium Chloride prevents cardiac rhythm disease,1581,"Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.","Is the triple ""Sodium Chloride prevents cardiac rhythm disease"" supported by the sentence: ""Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.""?",False, -18643598,Sodium Chloride prevents ventricular tachycardia,1582,"Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.","Is the triple ""Sodium Chloride prevents ventricular tachycardia"" supported by the sentence: ""Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.""?",False, -18145237,Sodium Chloride prevents Nausea,1583,The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).,"Is the triple ""Sodium Chloride prevents Nausea"" supported by the sentence: ""The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).""?",False, -17285701,Sodium Chloride prevents neuralgia,1584,"In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).","Is the triple ""Sodium Chloride prevents neuralgia"" supported by the sentence: ""In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).""?",False, -17081118,Sodium Chloride prevents cataract,1585,CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride prevents cataract"" supported by the sentence: ""CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.""?",False, -16603496,Sodium Chloride prevents brain injury,1586,DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.,"Is the triple ""Sodium Chloride prevents brain injury"" supported by the sentence: ""DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.""?",False, -16427621,Sodium Chloride prevents diabetes mellitus,1587,"Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.","Is the triple ""Sodium Chloride prevents diabetes mellitus"" supported by the sentence: ""Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.""?",False, -16310359,Sodium Chloride prevents burn,1588,CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.,"Is the triple ""Sodium Chloride prevents burn"" supported by the sentence: ""CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.""?",False, -16010295,Sodium Chloride prevents ischemic disease,1589,These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.,"Is the triple ""Sodium Chloride prevents ischemic disease"" supported by the sentence: ""These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.""?",False, -15507954,Sodium Chloride prevents pulmonary arterial hypertension,1590,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.","Is the triple ""Sodium Chloride prevents pulmonary arterial hypertension"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.""?",False, -15307837,Sodium Chloride prevents acute lung injury,1591,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.","Is the triple ""Sodium Chloride prevents acute lung injury"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.""?",False, -15219283,Sodium Chloride prevents allergic disease,1592,"KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.","Is the triple ""Sodium Chloride prevents allergic disease"" supported by the sentence: ""KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.""?",False, -14919203,Sodium Chloride prevents spinal cord injury,1593,Hydrogen-rich saline protects against spinal cord injury in rats.,"Is the triple ""Sodium Chloride prevents spinal cord injury"" supported by the sentence: ""Hydrogen-rich saline protects against spinal cord injury in rats.""?",False, -14359710,Sodium Chloride prevents obesity disorder,1594,"METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.","Is the triple ""Sodium Chloride prevents obesity disorder"" supported by the sentence: ""METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.""?",False, -14313516,Sodium Chloride prevents Inflammation,1595,"In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.","Is the triple ""Sodium Chloride prevents Inflammation"" supported by the sentence: ""In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.""?",False, -14313515,Sodium Chloride prevents ischemia reperfusion injury,1596,Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.,"Is the triple ""Sodium Chloride prevents ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.""?",False, -13297854,Sodium Chloride prevents kidney disorder,1597,"In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.","Is the triple ""Sodium Chloride prevents kidney disorder"" supported by the sentence: ""In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.""?",False, -12464836,Sodium Chloride prevents malaria,1598,"The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.","Is the triple ""Sodium Chloride prevents malaria"" supported by the sentence: ""The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.""?",False, -12453134,Sodium Chloride prevents iron deficiency anemia,1599,Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).,"Is the triple ""Sodium Chloride prevents iron deficiency anemia"" supported by the sentence: ""Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).""?",False, -12276610,Sodium Chloride prevents essential hypertension,1600,The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.,"Is the triple ""Sodium Chloride prevents essential hypertension"" supported by the sentence: ""The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.""?",False, -12092501,Sodium Chloride prevents hypertensive disorder,1601,"Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.","Is the triple ""Sodium Chloride prevents hypertensive disorder"" supported by the sentence: ""Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.""?",False, -11205687,Sodium Chloride prevents acute kidney failure,1602,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Chloride prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, -10429352,Sodium Chloride prevents injury,1603,"Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.","Is the triple ""Sodium Chloride prevents injury"" supported by the sentence: ""Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.""?",False, -10205494,Sodium Chloride prevents Hypovolemia,1604,"Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.","Is the triple ""Sodium Chloride prevents Hypovolemia"" supported by the sentence: ""Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.""?",False, -9628485,Sodium Chloride prevents anemia,1605,The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.,"Is the triple ""Sodium Chloride prevents anemia"" supported by the sentence: ""The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.""?",False, -8227059,Sodium Chloride prevents Shock,1606,The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.,"Is the triple ""Sodium Chloride prevents Shock"" supported by the sentence: ""The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.""?",False, -8196581,Sodium Chloride prevents dental caries,1607,Fluorinated salt was added to rations of preschool children for preventing dental caries.,"Is the triple ""Sodium Chloride prevents dental caries"" supported by the sentence: ""Fluorinated salt was added to rations of preschool children for preventing dental caries.""?",False, -8059428,Sodium Chloride prevents Pain,1608,"RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.","Is the triple ""Sodium Chloride prevents Pain"" supported by the sentence: ""RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.""?",False, -22103068,Sodium Chloride exacerbates hypertensive disorder,1609,The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.,"Is the triple ""Sodium Chloride exacerbates hypertensive disorder"" supported by the sentence: ""The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.""?",False, -20308305,Sodium Chloride exacerbates Inflammation,1610,"NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.","Is the triple ""Sodium Chloride exacerbates Inflammation"" supported by the sentence: ""NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.""?",False, -21816011,Sodium Chloride predisposes essential hypertension,1611,"This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.","Is the triple ""Sodium Chloride predisposes essential hypertension"" supported by the sentence: ""This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.""?",False, -19774957,Sodium Chloride predisposes pulmonary edema,1612,"Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.","Is the triple ""Sodium Chloride predisposes pulmonary edema"" supported by the sentence: ""Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.""?",False, -18380691,Sodium Chloride predisposes myocardial infarction,1613,"Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.","Is the triple ""Sodium Chloride predisposes myocardial infarction"" supported by the sentence: ""Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.""?",False, -18041213,Sodium Chloride predisposes Inflammation,1614,The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.,"Is the triple ""Sodium Chloride predisposes Inflammation"" supported by the sentence: ""The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.""?",False, -16033022,Sodium Chloride predisposes injury,1615,"In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.","Is the triple ""Sodium Chloride predisposes injury"" supported by the sentence: ""In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.""?",False, -13840593,Sodium Chloride predisposes allergic disease,1616,IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.,"Is the triple ""Sodium Chloride predisposes allergic disease"" supported by the sentence: ""IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.""?",False, -13808663,Sodium Chloride predisposes diabetes mellitus,1617,"Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.","Is the triple ""Sodium Chloride predisposes diabetes mellitus"" supported by the sentence: ""Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.""?",False, -13731023,Sodium Chloride predisposes cardiovascular disorder,1618,It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.,"Is the triple ""Sodium Chloride predisposes cardiovascular disorder"" supported by the sentence: ""It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.""?",False, -12280034,Sodium Chloride predisposes neoplasm,1619,"The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.","Is the triple ""Sodium Chloride predisposes neoplasm"" supported by the sentence: ""The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.""?",False, -12079247,Sodium Chloride predisposes hypertensive disorder,1620,"Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.","Is the triple ""Sodium Chloride predisposes hypertensive disorder"" supported by the sentence: ""Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.""?",False, -11776631,Sodium Chloride predisposes stroke disorder,1621,"These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.","Is the triple ""Sodium Chloride predisposes stroke disorder"" supported by the sentence: ""These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.""?",False, -11266800,Sodium Chloride predisposes kidney disorder,1622,"The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.","Is the triple ""Sodium Chloride predisposes kidney disorder"" supported by the sentence: ""The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.""?",False, -10118531,Sodium Chloride predisposes obesity disorder,1623,"To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).","Is the triple ""Sodium Chloride predisposes obesity disorder"" supported by the sentence: ""To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).""?",False, -9111875,Sodium Chloride predisposes cardiac rhythm disease,1624,"Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).","Is the triple ""Sodium Chloride predisposes cardiac rhythm disease"" supported by the sentence: ""Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).""?",False, -9647073,Dexpanthenol related to skin disorder,1625,Topical use of dexpanthenol in skin disorders.,"Is the triple ""Dexpanthenol related to skin disorder"" supported by the sentence: ""Topical use of dexpanthenol in skin disorders.""?",False, -26305399,Dexpanthenol affects Erythema,1626,"Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.","Is the triple ""Dexpanthenol affects Erythema"" supported by the sentence: ""Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.""?",False, -25421467,Dexpanthenol prevents cheilitis,1627,OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.,"Is the triple ""Dexpanthenol prevents cheilitis"" supported by the sentence: ""OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.""?",False, -24024712,ELTROMBOPAG related to autoimmune thrombocytopenic purpura,1628,"CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.","Is the triple ""ELTROMBOPAG related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.""?",False, -22097814,ELTROMBOPAG related to acute myeloid leukemia,1629,A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.,"Is the triple ""ELTROMBOPAG related to acute myeloid leukemia"" supported by the sentence: ""A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.""?",False, -22063304,ELTROMBOPAG related to aplastic anemia,1630,The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.,"Is the triple ""ELTROMBOPAG related to aplastic anemia"" supported by the sentence: ""The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.""?",False, -22063303,ELTROMBOPAG related to myelodysplastic syndrome,1631,We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.,"Is the triple ""ELTROMBOPAG related to myelodysplastic syndrome"" supported by the sentence: ""We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.""?",False, -22049758,ELTROMBOPAG related to thrombocytopenia,1632,"Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.","Is the triple ""ELTROMBOPAG related to thrombocytopenia"" supported by the sentence: ""Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.""?",False, -23835836,ELTROMBOPAG causes anemia,1633,This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.,"Is the triple ""ELTROMBOPAG causes anemia"" supported by the sentence: ""This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.""?",False, -22601227,ELTROMBOPAG affects thrombocytopenia,1634,The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.""?",False, -21709185,ELTROMBOPAG affects thrombocytopenia,1635,We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.""?",False, -22821304,ELTROMBOPAG prevents Hemorrhage,1636,"Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.","Is the triple ""ELTROMBOPAG prevents Hemorrhage"" supported by the sentence: ""Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.""?",False, -22169266,ELTROMBOPAG prevents thrombocytopenia,1637,We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.,"Is the triple ""ELTROMBOPAG prevents thrombocytopenia"" supported by the sentence: ""We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.""?",False, -12546229,Etamsylate affects Hemorrhage,1638,"Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.","Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.""?",False, -9791897,Etamsylate affects Hemorrhage,1639,Effect of Etamsylate on menstrual blood loss in women using IUDs.,"Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Effect of Etamsylate on menstrual blood loss in women using IUDs.""?",False, -22608563,Etamsylate prevents Hemorrhage,1640,Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.,"Is the triple ""Etamsylate prevents Hemorrhage"" supported by the sentence: ""Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.""?",False, -26536250,mitomycin C related to Deoxyribonucleic acid,1641,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, -26536250,mitomycin C related to Deoxyribonucleic acid,1642,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, -26158944,mitomycin C related to adenocarcinoma,1643,"Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.","Is the triple ""mitomycin C related to adenocarcinoma"" supported by the sentence: ""Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.""?",False, -26111339,mitomycin C related to squamous cell carcinoma,1644,"Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.","Is the triple ""mitomycin C related to squamous cell carcinoma"" supported by the sentence: ""Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.""?",False, -26043076,mitomycin C related to neoplasm,1645,"The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.","Is the triple ""mitomycin C related to neoplasm"" supported by the sentence: ""The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.""?",False, -25722815,mitomycin C related to leukemia,1646,"Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.","Is the triple ""mitomycin C related to leukemia"" supported by the sentence: ""Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.""?",False, -12722759,mitomycin C related to carcinoma,1647,"Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.","Is the triple ""mitomycin C related to carcinoma"" supported by the sentence: ""Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.""?",False, -10467532,mitomycin C related to non-small cell lung carcinoma,1648,"A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.","Is the triple ""mitomycin C related to non-small cell lung carcinoma"" supported by the sentence: ""A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.""?",False, -7255625,mitomycin C related to Deoxyribonucleic acid,1649,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, -7255625,mitomycin C related to Deoxyribonucleic acid,1650,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, -8689799,mitomycin C coexists with Deoxyribonucleic acid,1651,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, -8689799,mitomycin C coexists with Deoxyribonucleic acid,1652,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, -8030161,mitomycin C coexists with Deoxyribonucleic acid,1653,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, -8030161,mitomycin C coexists with Deoxyribonucleic acid,1654,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, -7255626,mitomycin C physically interacts with Deoxyribonucleic acid,1655,"Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.","Is the triple ""mitomycin C physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.""?",False, -25769130,mitomycin C causes sarcoma,1656,"Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.","Is the triple ""mitomycin C causes sarcoma"" supported by the sentence: ""Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.""?",False, -25692678,mitomycin C causes hepatocellular carcinoma,1657,The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.,"Is the triple ""mitomycin C causes hepatocellular carcinoma"" supported by the sentence: ""The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.""?",False, -20975852,mitomycin C causes carcinoma,1658,CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.,"Is the triple ""mitomycin C causes carcinoma"" supported by the sentence: ""CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.""?",False, -12184177,mitomycin C causes Corneal opacity,1659,"When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.","Is the triple ""mitomycin C causes Corneal opacity"" supported by the sentence: ""When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.""?",False, -11626710,mitomycin C causes urethral stricture,1660,Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.,"Is the triple ""mitomycin C causes urethral stricture"" supported by the sentence: ""Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.""?",False, -9485346,mitomycin C causes neoplasm,1661,The influence of mitomycin C on the induction of crown-gall tumors.,"Is the triple ""mitomycin C causes neoplasm"" supported by the sentence: ""The influence of mitomycin C on the induction of crown-gall tumors.""?",False, -26017044,mitomycin C affects squamous cell carcinoma,1662,Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.,"Is the triple ""mitomycin C affects squamous cell carcinoma"" supported by the sentence: ""Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.""?",False, -25924198,mitomycin C affects adenocarcinoma,1663,Effect of mitomycin-C on McCall rat colon adenocarcinoma.,"Is the triple ""mitomycin C affects adenocarcinoma"" supported by the sentence: ""Effect of mitomycin-C on McCall rat colon adenocarcinoma.""?",False, -24961205,mitomycin C affects neoplasm,1664,"CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.""?",False, -21183193,mitomycin C affects transitional cell carcinoma,1665,Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.,"Is the triple ""mitomycin C affects transitional cell carcinoma"" supported by the sentence: ""Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.""?",False, -20995393,mitomycin C affects urinary bladder neoplasm,1666,"Instillation of MMC markedly increased the development of bladder tumors, although CA did not.","Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""Instillation of MMC markedly increased the development of bladder tumors, although CA did not.""?",False, -20865956,mitomycin C affects pterygium,1667,Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.,"Is the triple ""mitomycin C affects pterygium"" supported by the sentence: ""Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.""?",False, -17166086,mitomycin C affects mesothelioma,1668,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""mitomycin C affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, -15342296,mitomycin C affects sclerosing cholangitis,1669,Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.,"Is the triple ""mitomycin C affects sclerosing cholangitis"" supported by the sentence: ""Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.""?",False, -14897135,mitomycin C affects Corneal opacity,1670,PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.,"Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.""?",False, -14480408,mitomycin C affects liver and intrahepatic bile duct neoplasm,1671,"The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.","Is the triple ""mitomycin C affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.""?",False, -14435862,mitomycin C affects Corneal opacity,1672,"Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.","Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.""?",False, -10146530,mitomycin C affects open-angle glaucoma,1673,A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.,"Is the triple ""mitomycin C affects open-angle glaucoma"" supported by the sentence: ""A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.""?",False, -8885108,mitomycin C affects urinary bladder neoplasm,1674,These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.,"Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.""?",False, -8612675,mitomycin C affects Deoxyribonucleic acid,1675,It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.,"Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.""?",False, -8242643,mitomycin C affects neoplasm,1676,"CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.""?",False, -8428809,mitomycin C affects Deoxyribonucleic acid,1677,"DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.","Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.""?",False, -26926271,mitomycin C disrupts Neoplasm Metastasis,1678,"When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.","Is the triple ""mitomycin C disrupts Neoplasm Metastasis"" supported by the sentence: ""When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.""?",False, -21172443,mitomycin C disrupts urinary bladder neoplasm,1679,"However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.","Is the triple ""mitomycin C disrupts urinary bladder neoplasm"" supported by the sentence: ""However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.""?",False, -16608751,mitomycin C disrupts carcinoma,1680,RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.,"Is the triple ""mitomycin C disrupts carcinoma"" supported by the sentence: ""RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.""?",False, -12093037,mitomycin C disrupts neoplasm,1681,"As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.","Is the triple ""mitomycin C disrupts neoplasm"" supported by the sentence: ""As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.""?",False, -8920186,mitomycin C disrupts Corneal opacity,1682,CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.,"Is the triple ""mitomycin C disrupts Corneal opacity"" supported by the sentence: ""CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.""?",False, -22973529,mitomycin C prevents glaucoma,1683,"CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.","Is the triple ""mitomycin C prevents glaucoma"" supported by the sentence: ""CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.""?",False, -19902018,mitomycin C prevents keratoconus,1684,Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.,"Is the triple ""mitomycin C prevents keratoconus"" supported by the sentence: ""Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.""?",False, -19673685,mitomycin C prevents urethral stricture,1685,Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.,"Is the triple ""mitomycin C prevents urethral stricture"" supported by the sentence: ""Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.""?",False, -12959208,mitomycin C prevents Neoplasm Metastasis,1686,"Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.","Is the triple ""mitomycin C prevents Neoplasm Metastasis"" supported by the sentence: ""Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.""?",False, -11642092,mitomycin C prevents Esophageal stenosis,1687,"The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.","Is the triple ""mitomycin C prevents Esophageal stenosis"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.""?",False, -9925117,mitomycin C prevents neoplasm,1688,"An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).","Is the triple ""mitomycin C prevents neoplasm"" supported by the sentence: ""An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).""?",False, -8410588,mitomycin C prevents pterygium,1689,"CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.","Is the triple ""mitomycin C prevents pterygium"" supported by the sentence: ""CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.""?",False, -7308263,mitomycin C prevents urinary bladder neoplasm,1690,"CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.","Is the triple ""mitomycin C prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.""?",False, -20886584,mitomycin C predisposes neoplasm,1691,These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.,"Is the triple ""mitomycin C predisposes neoplasm"" supported by the sentence: ""These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.""?",False, -17638153,Cefazolin related to bone fracture,1692,"The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.","Is the triple ""Cefazolin related to bone fracture"" supported by the sentence: ""The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.""?",False, -20958121,Cefazolin causes bacterial infectious disease with sepsis,1693,BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.,"Is the triple ""Cefazolin causes bacterial infectious disease with sepsis"" supported by the sentence: ""BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.""?",False, -25339548,Cefazolin affects obesity disorder,1694,"Overall, cefazolin pharmacokinetics are substantially altered in obesity.","Is the triple ""Cefazolin affects obesity disorder"" supported by the sentence: ""Overall, cefazolin pharmacokinetics are substantially altered in obesity.""?",False, -27670629,Cefazolin prevents staphylococcal infection,1695,PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.,"Is the triple ""Cefazolin prevents staphylococcal infection"" supported by the sentence: ""PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.""?",False, -10537097,Cefazolin prevents bacterial infectious disease,1696,"The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.","Is the triple ""Cefazolin prevents bacterial infectious disease"" supported by the sentence: ""The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.""?",False, -7415834,Famciclovir affects herpes zoster,1697,"However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.","Is the triple ""Famciclovir affects herpes zoster"" supported by the sentence: ""However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.""?",False, -27310156,Famciclovir disrupts viral infectious disease,1698,Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.,"Is the triple ""Famciclovir disrupts viral infectious disease"" supported by the sentence: ""Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.""?",False, -11859744,Famciclovir disrupts herpes simplex infectious disease,1699,OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.,"Is the triple ""Famciclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.""?",False, -11859743,Famciclovir disrupts genital herpes,1700,Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.,"Is the triple ""Famciclovir disrupts genital herpes"" supported by the sentence: ""Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.""?",False, -7415831,Famciclovir prevents herpes zoster,1701,"In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.","Is the triple ""Famciclovir prevents herpes zoster"" supported by the sentence: ""In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.""?",False, -27248580,Acyclovir related to herpes zoster,1702,Effect of acyclovir and prednisolone on the serological response in herpes zoster.,"Is the triple ""Acyclovir related to herpes zoster"" supported by the sentence: ""Effect of acyclovir and prednisolone on the serological response in herpes zoster.""?",False, -20916830,Acyclovir causes viral infectious disease,1703,"Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.","Is the triple ""Acyclovir causes viral infectious disease"" supported by the sentence: ""Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.""?",False, -21459205,Acyclovir affects herpes zoster,1704,"Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.","Is the triple ""Acyclovir affects herpes zoster"" supported by the sentence: ""Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.""?",False, -17108497,Acyclovir affects genital herpes,1705,In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.,"Is the triple ""Acyclovir affects genital herpes"" supported by the sentence: ""In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.""?",False, -15677184,Acyclovir affects viral infectious disease,1706,The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.,"Is the triple ""Acyclovir affects viral infectious disease"" supported by the sentence: ""The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.""?",False, -9966648,Acyclovir affects chickenpox,1707,2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.,"Is the triple ""Acyclovir affects chickenpox"" supported by the sentence: ""2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.""?",False, -8137898,Acyclovir affects cytomegalovirus infection,1708,"In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.","Is the triple ""Acyclovir affects cytomegalovirus infection"" supported by the sentence: ""In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.""?",False, -26100053,Acyclovir disrupts herpes zoster,1709,"When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.","Is the triple ""Acyclovir disrupts herpes zoster"" supported by the sentence: ""When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.""?",False, -21196251,Acyclovir disrupts cytomegalovirus infection,1710,"METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.","Is the triple ""Acyclovir disrupts cytomegalovirus infection"" supported by the sentence: ""METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.""?",False, -21045605,Acyclovir disrupts herpes simplex infectious disease,1711,Bortezomib and acyclovir acted synergistically to inhibit HSV infection.,"Is the triple ""Acyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Bortezomib and acyclovir acted synergistically to inhibit HSV infection.""?",False, -13979845,Acyclovir disrupts HIV infectious disease,1712,"In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.","Is the triple ""Acyclovir disrupts HIV infectious disease"" supported by the sentence: ""In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.""?",False, -11163493,Acyclovir disrupts chickenpox,1713,BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.,"Is the triple ""Acyclovir disrupts chickenpox"" supported by the sentence: ""BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.""?",False, -10081763,Acyclovir disrupts viral infectious disease,1714,"Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.","Is the triple ""Acyclovir disrupts viral infectious disease"" supported by the sentence: ""Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.""?",False, -8112053,Acyclovir disrupts genital herpes,1715,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Acyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, -22220716,Acyclovir prevents chickenpox,1716,Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.,"Is the triple ""Acyclovir prevents chickenpox"" supported by the sentence: ""Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.""?",False, -14453930,Acyclovir prevents herpes zoster,1717,Continuous administration of ACV decreased the incidence of HZ infection.,"Is the triple ""Acyclovir prevents herpes zoster"" supported by the sentence: ""Continuous administration of ACV decreased the incidence of HZ infection.""?",False, -11048138,Acyclovir prevents herpes labialis,1718,The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.,"Is the triple ""Acyclovir prevents herpes labialis"" supported by the sentence: ""The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.""?",False, -10652424,Acyclovir prevents viral infectious disease,1719,The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.,"Is the triple ""Acyclovir prevents viral infectious disease"" supported by the sentence: ""The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.""?",False, -9977810,Acyclovir prevents genital herpes,1720,CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.,"Is the triple ""Acyclovir prevents genital herpes"" supported by the sentence: ""CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.""?",False, -8973083,Acyclovir prevents cytomegalovirus infection,1721,The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.,"Is the triple ""Acyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.""?",False, -8455850,Acyclovir prevents herpes simplex infectious disease,1722,"HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.","Is the triple ""Acyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.""?",False, -16777411,Acyclovir predisposes herpes simplex infectious disease,1723,"CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.","Is the triple ""Acyclovir predisposes herpes simplex infectious disease"" supported by the sentence: ""CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.""?",False, -14602481,Acyclovir predisposes HIV infectious disease,1724,We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.,"Is the triple ""Acyclovir predisposes HIV infectious disease"" supported by the sentence: ""We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.""?",False, -7066348,Idoxuridine coexists with Deoxyribonucleic acid,1725,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, -7066348,Idoxuridine coexists with Deoxyribonucleic acid,1726,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, -10786366,Idoxuridine coexists with Deoxyribonucleic acid,1727,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, -10786366,Idoxuridine coexists with Deoxyribonucleic acid,1728,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, -15969143,Idoxuridine derives from Deoxyribonucleic acid,1729,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, -15969143,Idoxuridine derives from Deoxyribonucleic acid,1730,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, -10765452,Idoxuridine physically interacts with Deoxyribonucleic acid,1731,Role of MutSalpha in the recognition of iododeoxyuridine in DNA.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Role of MutSalpha in the recognition of iododeoxyuridine in DNA.""?",False, -8193345,Idoxuridine physically interacts with Deoxyribonucleic acid,1732,The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.""?",False, -13332148,Idoxuridine causes viral infectious disease,1733,"Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.","Is the triple ""Idoxuridine causes viral infectious disease"" supported by the sentence: ""Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.""?",False, -25762983,Idoxuridine affects viral infectious disease,1734,Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.,"Is the triple ""Idoxuridine affects viral infectious disease"" supported by the sentence: ""Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.""?",False, -25024576,Idoxuridine affects Deoxyribonucleic acid,1735,"Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.","Is the triple ""Idoxuridine affects Deoxyribonucleic acid"" supported by the sentence: ""Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.""?",False, -25798138,Vidarabine affects herpes simplex infectious disease,1736,Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.,"Is the triple ""Vidarabine affects herpes simplex infectious disease"" supported by the sentence: ""Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.""?",False, -18005400,Ganciclovir related to AIDS,1737,[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].,"Is the triple ""Ganciclovir related to AIDS"" supported by the sentence: ""[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].""?",False, -11769089,Ganciclovir related to lymphoma,1738,Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.,"Is the triple ""Ganciclovir related to lymphoma"" supported by the sentence: ""Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.""?",False, -7813894,Ganciclovir causes hepatocellular carcinoma,1739,"However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.","Is the triple ""Ganciclovir causes hepatocellular carcinoma"" supported by the sentence: ""However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.""?",False, -21315977,Ganciclovir affects melanoma,1740,"In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.","Is the triple ""Ganciclovir affects melanoma"" supported by the sentence: ""In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.""?",False, -18696617,Ganciclovir affects viral infectious disease,1741,"It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.","Is the triple ""Ganciclovir affects viral infectious disease"" supported by the sentence: ""It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.""?",False, -14018850,Ganciclovir affects graft versus host disease,1742,OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).,"Is the triple ""Ganciclovir affects graft versus host disease"" supported by the sentence: ""OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).""?",False, -7745805,Ganciclovir affects hepatocellular carcinoma,1743,"Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.","Is the triple ""Ganciclovir affects hepatocellular carcinoma"" supported by the sentence: ""Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.""?",False, -7264703,Ganciclovir affects retinitis,1744,"CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.","Is the triple ""Ganciclovir affects retinitis"" supported by the sentence: ""CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.""?",False, -7193112,Ganciclovir affects cytomegalovirus retinitis,1745,"Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.","Is the triple ""Ganciclovir affects cytomegalovirus retinitis"" supported by the sentence: ""Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.""?",False, -27515973,Ganciclovir disrupts viral infectious disease,1746,"Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.","Is the triple ""Ganciclovir disrupts viral infectious disease"" supported by the sentence: ""Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.""?",False, -20042666,Ganciclovir disrupts glioblastoma,1747,"Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.","Is the triple ""Ganciclovir disrupts glioblastoma"" supported by the sentence: ""Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.""?",False, -11829393,Ganciclovir disrupts cytomegalovirus infection,1748,CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.,"Is the triple ""Ganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.""?",False, -9242712,Ganciclovir disrupts hepatocellular carcinoma,1749,Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.,"Is the triple ""Ganciclovir disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.""?",False, -27273103,Ganciclovir prevents retinitis,1750,"TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.","Is the triple ""Ganciclovir prevents retinitis"" supported by the sentence: ""TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.""?",False, -14947813,Ganciclovir prevents viral infectious disease,1751,"This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.","Is the triple ""Ganciclovir prevents viral infectious disease"" supported by the sentence: ""This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.""?",False, -8898867,Ganciclovir prevents cytomegalovirus retinitis,1752,"Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.","Is the triple ""Ganciclovir prevents cytomegalovirus retinitis"" supported by the sentence: ""Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.""?",False, -7606615,Ganciclovir prevents cytomegalovirus infection,1753,"Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.","Is the triple ""Ganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.""?",False, -26756507,Nedocromil affects asthma,1754,"As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.","Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.""?",False, -12807968,Nedocromil affects asthma,1755,AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.,"Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.""?",False, -15773495,Nedocromil disrupts asthma,1756,Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.,"Is the triple ""Nedocromil disrupts asthma"" supported by the sentence: ""Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.""?",False, -26602335,Nedocromil prevents asthma,1757,Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.,"Is the triple ""Nedocromil prevents asthma"" supported by the sentence: ""Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.""?",False, -25857910,Flumedroxone related to migraine disorder,1758,"A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.","Is the triple ""Flumedroxone related to migraine disorder"" supported by the sentence: ""A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.""?",False, -26456255,Valrubicin coexists with Deoxyribonucleic acid,1759,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, -26456255,Valrubicin coexists with Deoxyribonucleic acid,1760,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, -26331358,Valrubicin affects Deoxyribonucleic acid,1761,The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.,"Is the triple ""Valrubicin affects Deoxyribonucleic acid"" supported by the sentence: ""The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.""?",False, -9013591,Valrubicin affects neoplasm,1762,OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).,"Is the triple ""Valrubicin affects neoplasm"" supported by the sentence: ""OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).""?",False, -15048973,Valrubicin disrupts neoplasm,1763,Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.,"Is the triple ""Valrubicin disrupts neoplasm"" supported by the sentence: ""Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.""?",False, -19780799,"Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive",1764,"BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.","Is the triple ""Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.""?",False, -19123529,Idarubicin related to acute lymphoblastic leukemia,1765,"A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.","Is the triple ""Idarubicin related to acute lymphoblastic leukemia"" supported by the sentence: ""A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.""?",False, -17160344,Idarubicin related to myelodysplastic syndrome,1766,"Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.","Is the triple ""Idarubicin related to myelodysplastic syndrome"" supported by the sentence: ""Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.""?",False, -13481436,Idarubicin related to acute myeloid leukemia,1767,Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).,"Is the triple ""Idarubicin related to acute myeloid leukemia"" supported by the sentence: ""Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).""?",False, -12261572,Idarubicin related to plasma cell myeloma,1768,"High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.","Is the triple ""Idarubicin related to plasma cell myeloma"" supported by the sentence: ""High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.""?",False, -10347974,Idarubicin related to non-Hodgkin lymphoma,1769,"Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.","Is the triple ""Idarubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.""?",False, -8798925,Idarubicin related to acute promyelocytic leukemia,1770,Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.,"Is the triple ""Idarubicin related to acute promyelocytic leukemia"" supported by the sentence: ""Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.""?",False, -17955637,Idarubicin causes acute myeloid leukemia,1771,"On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.","Is the triple ""Idarubicin causes acute myeloid leukemia"" supported by the sentence: ""On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.""?",False, -10037923,Idarubicin causes neutropenia,1772,The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.,"Is the triple ""Idarubicin causes neutropenia"" supported by the sentence: ""The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.""?",False, -27637811,Idarubicin affects acute myeloid leukemia,1773,"In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.""?",False, -27582612,Idarubicin affects acute lymphoblastic leukemia,1774,The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.,"Is the triple ""Idarubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.""?",False, -27363552,Idarubicin affects neoplasm,1775,"However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.""?",False, -10133635,Idarubicin affects acute myeloid leukemia,1776,"Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.""?",False, -9755321,Idarubicin affects leukemia,1777,"We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.","Is the triple ""Idarubicin affects leukemia"" supported by the sentence: ""We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.""?",False, -9560678,Idarubicin affects neoplasm,1778,"Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.""?",False, -9242996,Idarubicin affects neutropenia,1779,These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.,"Is the triple ""Idarubicin affects neutropenia"" supported by the sentence: ""These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.""?",False, -18342294,Pirarubicin causes neoplasm,1780,RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.,"Is the triple ""Pirarubicin causes neoplasm"" supported by the sentence: ""RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.""?",False, -16182034,Pirarubicin affects neoplasm,1781,Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.,"Is the triple ""Pirarubicin affects neoplasm"" supported by the sentence: ""Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.""?",False, -19153993,Pirarubicin disrupts neoplasm,1782,"As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.","Is the triple ""Pirarubicin disrupts neoplasm"" supported by the sentence: ""As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.""?",False, -14778803,Pirarubicin prevents neoplasm,1783,"Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.","Is the triple ""Pirarubicin prevents neoplasm"" supported by the sentence: ""Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.""?",False, -20218174,Mitoxantrone subclass of Mitoxantrone dicarboxylic acid,1784,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone subclass of Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, -25737166,Mitoxantrone related to lymphoma,1785,"Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.","Is the triple ""Mitoxantrone related to lymphoma"" supported by the sentence: ""Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.""?",False, -19961419,Mitoxantrone related to breast neoplasm,1786,Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.,"Is the triple ""Mitoxantrone related to breast neoplasm"" supported by the sentence: ""Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.""?",False, -14217137,Mitoxantrone related to mantle cell lymphoma,1787,Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.,"Is the triple ""Mitoxantrone related to mantle cell lymphoma"" supported by the sentence: ""Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.""?",False, -13051364,Mitoxantrone related to multiple sclerosis,1788,"Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.","Is the triple ""Mitoxantrone related to multiple sclerosis"" supported by the sentence: ""Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.""?",False, -8903075,Mitoxantrone related to acute myeloid leukemia,1789,"Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.","Is the triple ""Mitoxantrone related to acute myeloid leukemia"" supported by the sentence: ""Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.""?",False, -8584278,Mitoxantrone causes acute myeloid leukemia,1790,"CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.","Is the triple ""Mitoxantrone causes acute myeloid leukemia"" supported by the sentence: ""CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.""?",False, -26143277,Mitoxantrone affects lymphoma,1791,"Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.","Is the triple ""Mitoxantrone affects lymphoma"" supported by the sentence: ""Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.""?",False, -20218175,Mitoxantrone affects Mitoxantrone dicarboxylic acid,1792,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone affects Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, -11986455,Mitoxantrone affects multiple sclerosis,1793,Therapeutic role of mitoxantrone in multiple sclerosis.,"Is the triple ""Mitoxantrone affects multiple sclerosis"" supported by the sentence: ""Therapeutic role of mitoxantrone in multiple sclerosis.""?",False, -9134230,Mitoxantrone prevents neoplasm,1794,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Mitoxantrone prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, -11307631,Mitoxantrone exacerbates multiple sclerosis,1795,Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.,"Is the triple ""Mitoxantrone exacerbates multiple sclerosis"" supported by the sentence: ""Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.""?",False, -26844498,Doxorubicin related to renal cell carcinoma,1796,Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.,"Is the triple ""Doxorubicin related to renal cell carcinoma"" supported by the sentence: ""Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.""?",False, -26506763,Doxorubicin related to Kaposi's sarcoma,1797,"The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.","Is the triple ""Doxorubicin related to Kaposi's sarcoma"" supported by the sentence: ""The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.""?",False, -26097255,Doxorubicin related to hepatocellular carcinoma,1798,The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.,"Is the triple ""Doxorubicin related to hepatocellular carcinoma"" supported by the sentence: ""The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.""?",False, -25468576,Doxorubicin related to non-Hodgkin lymphoma,1799,"OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.","Is the triple ""Doxorubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.""?",False, -21586070,Doxorubicin related to diffuse large B-cell lymphoma,1800,"Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.","Is the triple ""Doxorubicin related to diffuse large B-cell lymphoma"" supported by the sentence: ""Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.""?",False, -17293414,Doxorubicin related to neoplasm,1801,"Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.","Is the triple ""Doxorubicin related to neoplasm"" supported by the sentence: ""Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.""?",False, -14824461,Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma,1802,"A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.","Is the triple ""Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.""?",False, -12975330,"Doxorubicin related to Lymphoma, AIDS-Related",1803,"BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.","Is the triple ""Doxorubicin related to Lymphoma, AIDS-Related"" supported by the sentence: ""BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.""?",False, -12635005,Doxorubicin related to neuroendocrine neoplasm,1804,"Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.","Is the triple ""Doxorubicin related to neuroendocrine neoplasm"" supported by the sentence: ""Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.""?",False, -11664648,Doxorubicin related to non-small cell lung carcinoma,1805,"Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.","Is the triple ""Doxorubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.""?",False, -8248824,Doxorubicin related to lymphoma,1806,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Doxorubicin related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, -7897058,Doxorubicin related to leukemia,1807,Combined effect of lipoic acid and doxorubicin in murine leukemia.,"Is the triple ""Doxorubicin related to leukemia"" supported by the sentence: ""Combined effect of lipoic acid and doxorubicin in murine leukemia.""?",False, -7111309,Doxorubicin related to Hodgkins lymphoma,1808,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Doxorubicin related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, -26198671,Doxorubicin causes acute myeloid leukemia,1809,"Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.","Is the triple ""Doxorubicin causes acute myeloid leukemia"" supported by the sentence: ""Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.""?",False, -20905498,Doxorubicin causes prostate cancer,1810,"In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.","Is the triple ""Doxorubicin causes prostate cancer"" supported by the sentence: ""In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.""?",False, -19998968,Doxorubicin causes Hodgkins lymphoma,1811,"Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.","Is the triple ""Doxorubicin causes Hodgkins lymphoma"" supported by the sentence: ""Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.""?",False, -17176693,Doxorubicin causes B-cell neoplasm,1812,"Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.","Is the triple ""Doxorubicin causes B-cell neoplasm"" supported by the sentence: ""Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.""?",False, -16306119,Doxorubicin causes hepatocellular carcinoma,1813,"In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.","Is the triple ""Doxorubicin causes hepatocellular carcinoma"" supported by the sentence: ""In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.""?",False, -14936910,Doxorubicin causes plasma cell myeloma,1814,"Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.","Is the triple ""Doxorubicin causes plasma cell myeloma"" supported by the sentence: ""Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.""?",False, -13613509,Doxorubicin causes sarcoma,1815,Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.,"Is the triple ""Doxorubicin causes sarcoma"" supported by the sentence: ""Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.""?",False, -12176485,"Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive",1816,"Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.","Is the triple ""Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.""?",False, -12086573,Doxorubicin causes leukemia,1817,"We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.","Is the triple ""Doxorubicin causes leukemia"" supported by the sentence: ""We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.""?",False, -11480674,Doxorubicin causes Neoplasm Metastasis,1818,"The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.","Is the triple ""Doxorubicin causes Neoplasm Metastasis"" supported by the sentence: ""The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.""?",False, -11088747,Doxorubicin causes neoplasm,1819,"Furthermore, doxorubicin is known to induce tumor resistance genes.","Is the triple ""Doxorubicin causes neoplasm"" supported by the sentence: ""Furthermore, doxorubicin is known to induce tumor resistance genes.""?",False, -7374660,Doxorubicin causes neutropenia,1820,"Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.","Is the triple ""Doxorubicin causes neutropenia"" supported by the sentence: ""Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.""?",False, -25410483,Doxorubicin affects glioma,1821,"By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.","Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.""?",False, -25202161,Doxorubicin affects glioblastoma,1822,The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.,"Is the triple ""Doxorubicin affects glioblastoma"" supported by the sentence: ""The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.""?",False, -24066270,Doxorubicin affects triple-negative breast carcinoma,1823,Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.,"Is the triple ""Doxorubicin affects triple-negative breast carcinoma"" supported by the sentence: ""Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.""?",False, -23980169,Doxorubicin affects hematopoietic and lymphoid system neoplasm,1824,"Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.","Is the triple ""Doxorubicin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.""?",False, -20976248,Doxorubicin affects neuroblastoma,1825,"For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.","Is the triple ""Doxorubicin affects neuroblastoma"" supported by the sentence: ""For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.""?",False, -20526631,Doxorubicin affects gastric neoplasm,1826,"Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.","Is the triple ""Doxorubicin affects gastric neoplasm"" supported by the sentence: ""Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.""?",False, -20464122,Doxorubicin affects T-cell non-Hodgkin lymphoma,1827,"Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.","Is the triple ""Doxorubicin affects T-cell non-Hodgkin lymphoma"" supported by the sentence: ""Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.""?",False, -19907850,Doxorubicin affects renal cell carcinoma,1828,"Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.","Is the triple ""Doxorubicin affects renal cell carcinoma"" supported by the sentence: ""Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.""?",False, -18966824,Doxorubicin affects leiomyosarcoma,1829,"Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.","Is the triple ""Doxorubicin affects leiomyosarcoma"" supported by the sentence: ""Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.""?",False, -18841320,Doxorubicin affects B-cell chronic lymphocytic leukemia,1830,This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.,"Is the triple ""Doxorubicin affects B-cell chronic lymphocytic leukemia"" supported by the sentence: ""This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.""?",False, -17410518,Doxorubicin affects rhabdomyosarcoma,1831,The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.,"Is the triple ""Doxorubicin affects rhabdomyosarcoma"" supported by the sentence: ""The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.""?",False, -17166104,Doxorubicin affects mesothelioma,1832,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""Doxorubicin affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, -17156749,Doxorubicin affects non-Hodgkin lymphoma,1833,From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).,"Is the triple ""Doxorubicin affects non-Hodgkin lymphoma"" supported by the sentence: ""From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).""?",False, -17092174,Doxorubicin affects glioma,1834,Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.,"Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.""?",False, -16319458,Doxorubicin affects sarcoma,1835,Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.,"Is the triple ""Doxorubicin affects sarcoma"" supported by the sentence: ""Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.""?",False, -15641121,Doxorubicin affects liver and intrahepatic bile duct neoplasm,1836,"The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.","Is the triple ""Doxorubicin affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.""?",False, -15592048,Doxorubicin affects diffuse large B-cell lymphoma,1837,"Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.","Is the triple ""Doxorubicin affects diffuse large B-cell lymphoma"" supported by the sentence: ""Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.""?",False, -15335028,Doxorubicin affects pancreatic ductal adenocarcinoma,1838,"We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.","Is the triple ""Doxorubicin affects pancreatic ductal adenocarcinoma"" supported by the sentence: ""We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.""?",False, -15288278,Doxorubicin affects mantle cell lymphoma,1839,"Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.","Is the triple ""Doxorubicin affects mantle cell lymphoma"" supported by the sentence: ""Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.""?",False, -15233880,Doxorubicin affects prostate cancer,1840,"In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.","Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.""?",False, -14862593,Doxorubicin affects liposarcoma,1841,"We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.","Is the triple ""Doxorubicin affects liposarcoma"" supported by the sentence: ""We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.""?",False, -13717435,Doxorubicin affects prostate cancer,1842,CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.,"Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.""?",False, -13641465,Doxorubicin affects Ewing sarcoma,1843,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects Ewing sarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, -13641464,Doxorubicin affects bone osteosarcoma,1844,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects bone osteosarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, -13477582,Doxorubicin affects hepatocellular carcinoma,1845,Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.,"Is the triple ""Doxorubicin affects hepatocellular carcinoma"" supported by the sentence: ""Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.""?",False, -12593977,Doxorubicin affects Kaposi's sarcoma,1846,Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.,"Is the triple ""Doxorubicin affects Kaposi's sarcoma"" supported by the sentence: ""Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.""?",False, -12038917,Doxorubicin affects acute lymphoblastic leukemia,1847,Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.,"Is the triple ""Doxorubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.""?",False, -11963770,Doxorubicin affects angiosarcoma,1848,DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.,"Is the triple ""Doxorubicin affects angiosarcoma"" supported by the sentence: ""DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.""?",False, -11068243,Doxorubicin affects neutropenia,1849,"Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.","Is the triple ""Doxorubicin affects neutropenia"" supported by the sentence: ""Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.""?",False, -9029101,Doxorubicin affects neoplasm,1850,"Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.""?",False, -7957058,Doxorubicin affects neoplasm,1851,"In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.""?",False, -7468708,Doxorubicin affects carcinoma,1852,Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.,"Is the triple ""Doxorubicin affects carcinoma"" supported by the sentence: ""Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.""?",False, -7221748,Doxorubicin affects small cell lung carcinoma,1853,"Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.","Is the triple ""Doxorubicin affects small cell lung carcinoma"" supported by the sentence: ""Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.""?",False, -22415368,Doxorubicin disrupts glioma,1854,"In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.","Is the triple ""Doxorubicin disrupts glioma"" supported by the sentence: ""In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.""?",False, -21775806,Doxorubicin disrupts non-small cell lung carcinoma,1855,Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.,"Is the triple ""Doxorubicin disrupts non-small cell lung carcinoma"" supported by the sentence: ""Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.""?",False, -19908932,Doxorubicin disrupts hematopoietic and lymphoid system neoplasm,1856,Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.,"Is the triple ""Doxorubicin disrupts hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.""?",False, -19216444,Doxorubicin disrupts lymphoma,1857,Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.,"Is the triple ""Doxorubicin disrupts lymphoma"" supported by the sentence: ""Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.""?",False, -18593046,Doxorubicin disrupts bone osteosarcoma,1858,"A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.","Is the triple ""Doxorubicin disrupts bone osteosarcoma"" supported by the sentence: ""A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.""?",False, -17338969,Doxorubicin disrupts melanoma,1859,In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).,"Is the triple ""Doxorubicin disrupts melanoma"" supported by the sentence: ""In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).""?",False, -15233882,Doxorubicin disrupts prostate cancer,1860,"In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.","Is the triple ""Doxorubicin disrupts prostate cancer"" supported by the sentence: ""In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.""?",False, -15026936,Doxorubicin disrupts B-cell neoplasm,1861,"RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.","Is the triple ""Doxorubicin disrupts B-cell neoplasm"" supported by the sentence: ""RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.""?",False, -14123664,Doxorubicin disrupts hepatocellular carcinoma,1862,CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.,"Is the triple ""Doxorubicin disrupts hepatocellular carcinoma"" supported by the sentence: ""CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.""?",False, -11529496,Doxorubicin disrupts neuroblastoma,1863,"We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.","Is the triple ""Doxorubicin disrupts neuroblastoma"" supported by the sentence: ""We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.""?",False, -8800155,Doxorubicin disrupts neoplasm,1864,"Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).","Is the triple ""Doxorubicin disrupts neoplasm"" supported by the sentence: ""Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).""?",False, -8316270,Doxorubicin disrupts Neoplasm Metastasis,1865,"However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.","Is the triple ""Doxorubicin disrupts Neoplasm Metastasis"" supported by the sentence: ""However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.""?",False, -24403937,Doxorubicin prevents triple-negative breast carcinoma,1866,"Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.","Is the triple ""Doxorubicin prevents triple-negative breast carcinoma"" supported by the sentence: ""Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.""?",False, -23195923,Doxorubicin prevents lung neoplasm,1867,In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.,"Is the triple ""Doxorubicin prevents lung neoplasm"" supported by the sentence: ""In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.""?",False, -22365593,Doxorubicin prevents leukemia,1868,"Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.","Is the triple ""Doxorubicin prevents leukemia"" supported by the sentence: ""Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.""?",False, -15227703,Doxorubicin prevents sarcoma,1869,"In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.","Is the triple ""Doxorubicin prevents sarcoma"" supported by the sentence: ""In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.""?",False, -10708896,Doxorubicin prevents urinary bladder neoplasm,1870,"CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.","Is the triple ""Doxorubicin prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.""?",False, -8872024,Doxorubicin prevents Neoplasm Metastasis,1871,"Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.","Is the triple ""Doxorubicin prevents Neoplasm Metastasis"" supported by the sentence: ""Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.""?",False, -8737011,Doxorubicin prevents neutropenia,1872,"CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.","Is the triple ""Doxorubicin prevents neutropenia"" supported by the sentence: ""CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.""?",False, -7721507,Doxorubicin prevents neoplasm,1873,"(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.","Is the triple ""Doxorubicin prevents neoplasm"" supported by the sentence: ""(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.""?",False, -18908502,Doxorubicin exacerbates neoplasm,1874,"Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.","Is the triple ""Doxorubicin exacerbates neoplasm"" supported by the sentence: ""Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.""?",False, -25000938,Doxorubicin predisposes bone osteosarcoma,1875,"CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.","Is the triple ""Doxorubicin predisposes bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.""?",False, -20426915,Doxorubicin predisposes neoplasm,1876,Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.,"Is the triple ""Doxorubicin predisposes neoplasm"" supported by the sentence: ""Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.""?",False, -19669792,Doxorubicin predisposes sarcoma,1877,"Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.","Is the triple ""Doxorubicin predisposes sarcoma"" supported by the sentence: ""Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.""?",False, -18137816,Doxorubicin predisposes lymphoma,1878,"Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.","Is the triple ""Doxorubicin predisposes lymphoma"" supported by the sentence: ""Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.""?",False, -12722667,Doxorubicin predisposes acute myeloid leukemia,1879,"Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.","Is the triple ""Doxorubicin predisposes acute myeloid leukemia"" supported by the sentence: ""Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.""?",False, -8803332,Doxorubicin predisposes kidney Wilms tumor,1880,CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.,"Is the triple ""Doxorubicin predisposes kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.""?",False, -7173827,Doxorubicin predisposes leukemia,1881,"CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.","Is the triple ""Doxorubicin predisposes leukemia"" supported by the sentence: ""CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.""?",False, -26966260,Iproniazid related to Monoamine Oxidase,1882,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, -26966260,Iproniazid related to Monoamine Oxidase,1883,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, -10565399,Iproniazid physically interacts with Monoamine Oxidase,1884,The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.,"Is the triple ""Iproniazid physically interacts with Monoamine Oxidase"" supported by the sentence: ""The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.""?",False, -12902070,Iproniazid affects depressive disorder,1885,"Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.","Is the triple ""Iproniazid affects depressive disorder"" supported by the sentence: ""Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.""?",False, -9833655,Iproniazid affects Monoamine Oxidase,1886,"The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.","Is the triple ""Iproniazid affects Monoamine Oxidase"" supported by the sentence: ""The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.""?",False, -10498318,Epirubicin related to non-small cell lung carcinoma,1887,Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.,"Is the triple ""Epirubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.""?",False, -10228088,Epirubicin related to ovarian cancer,1888,Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.,"Is the triple ""Epirubicin related to ovarian cancer"" supported by the sentence: ""Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.""?",False, -10182077,Epirubicin related to non-Hodgkin lymphoma,1889,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, -10182076,Epirubicin related to Hodgkins lymphoma,1890,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to Hodgkins lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, -8413603,Epirubicin related to small cell lung carcinoma,1891,"Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.","Is the triple ""Epirubicin related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.""?",False, -7746533,Epirubicin related to castration-resistant prostate carcinoma,1892,"The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.","Is the triple ""Epirubicin related to castration-resistant prostate carcinoma"" supported by the sentence: ""The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.""?",False, -26737878,Epirubicin physically interacts with 7-Deoxydoxorubicinone,1893,"In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.","Is the triple ""Epirubicin physically interacts with 7-Deoxydoxorubicinone"" supported by the sentence: ""In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.""?",False, -18781215,Epirubicin causes neoplasm,1894,"In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.","Is the triple ""Epirubicin causes neoplasm"" supported by the sentence: ""In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.""?",False, -26736958,Epirubicin affects hepatocellular carcinoma,1895,"Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.","Is the triple ""Epirubicin affects hepatocellular carcinoma"" supported by the sentence: ""Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.""?",False, -12104701,Epirubicin affects neoplasm,1896,RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.,"Is the triple ""Epirubicin affects neoplasm"" supported by the sentence: ""RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.""?",False, -14784473,Epirubicin prevents neoplasm,1897,"The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.","Is the triple ""Epirubicin prevents neoplasm"" supported by the sentence: ""The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.""?",False, -10544897,Nialamide physically interacts with Monoamine Oxidase,1898,"The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.","Is the triple ""Nialamide physically interacts with Monoamine Oxidase"" supported by the sentence: ""The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.""?",False, -9388429,Nialamide affects Monoamine Oxidase,1899,"Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.","Is the triple ""Nialamide affects Monoamine Oxidase"" supported by the sentence: ""Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.""?",False, -10646811,Isocarboxazid affects Monoamine Oxidase,1900,Monoamine oxidase inhibition by isocarboxazid.,"Is the triple ""Isocarboxazid affects Monoamine Oxidase"" supported by the sentence: ""Monoamine oxidase inhibition by isocarboxazid.""?",False, -14451724,Valacyclovir causes psychotic disorder,1901,"Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.","Is the triple ""Valacyclovir causes psychotic disorder"" supported by the sentence: ""Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.""?",False, -27205274,Valacyclovir affects postherpetic neuralgia,1902,"The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.","Is the triple ""Valacyclovir affects postherpetic neuralgia"" supported by the sentence: ""The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.""?",False, -25557382,Valacyclovir affects Pregnancy,1903,"METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).","Is the triple ""Valacyclovir affects Pregnancy"" supported by the sentence: ""METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).""?",False, -19384061,Valacyclovir disrupts herpes simplex infectious disease,1904,Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.,"Is the triple ""Valacyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.""?",False, -14963245,Valacyclovir disrupts herpes zoster,1905,VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.,"Is the triple ""Valacyclovir disrupts herpes zoster"" supported by the sentence: ""VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.""?",False, -10778326,Valacyclovir disrupts viral infectious disease,1906,"To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.","Is the triple ""Valacyclovir disrupts viral infectious disease"" supported by the sentence: ""To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.""?",False, -10108851,Valacyclovir disrupts herpes labialis,1907,The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.,"Is the triple ""Valacyclovir disrupts herpes labialis"" supported by the sentence: ""The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.""?",False, -8112054,Valacyclovir disrupts genital herpes,1908,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Valacyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, -19368060,Valacyclovir prevents postherpetic neuralgia,1909,FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.,"Is the triple ""Valacyclovir prevents postherpetic neuralgia"" supported by the sentence: ""FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.""?",False, -12346968,Valacyclovir prevents genital herpes,1910,Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.,"Is the triple ""Valacyclovir prevents genital herpes"" supported by the sentence: ""Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.""?",False, -10108849,Valacyclovir prevents herpes labialis,1911,"Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.","Is the triple ""Valacyclovir prevents herpes labialis"" supported by the sentence: ""Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.""?",False, -9970234,Valacyclovir prevents herpes simplex infectious disease,1912,Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.,"Is the triple ""Valacyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.""?",False, -8018684,Valacyclovir prevents cytomegalovirus infection,1913,The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.,"Is the triple ""Valacyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.""?",False, -8899981,Cidofovir affects cytomegalovirus retinitis,1914,The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.,"Is the triple ""Cidofovir affects cytomegalovirus retinitis"" supported by the sentence: ""The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.""?",False, -7346321,Cidofovir affects viral infectious disease,1915,The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.,"Is the triple ""Cidofovir affects viral infectious disease"" supported by the sentence: ""The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.""?",False, -11567412,Cidofovir disrupts cytomegalovirus infection,1916,These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.,"Is the triple ""Cidofovir disrupts cytomegalovirus infection"" supported by the sentence: ""These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.""?",False, -27502123,Cidofovir prevents herpes simplex infectious disease,1917,Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.,"Is the triple ""Cidofovir prevents herpes simplex infectious disease"" supported by the sentence: ""Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.""?",False, -16212718,Cidofovir prevents cytomegalovirus infection,1918,"* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.","Is the triple ""Cidofovir prevents cytomegalovirus infection"" supported by the sentence: ""* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.""?",False, -11248462,Cidofovir prevents viral infectious disease,1919,"Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.","Is the triple ""Cidofovir prevents viral infectious disease"" supported by the sentence: ""Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.""?",False, -26922185,Penciclovir affects viral infectious disease,1920,"Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.","Is the triple ""Penciclovir affects viral infectious disease"" supported by the sentence: ""Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.""?",False, -22087736,Valganciclovir affects cytomegalovirus infection,1921,The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.,"Is the triple ""Valganciclovir affects cytomegalovirus infection"" supported by the sentence: ""The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.""?",False, -18756429,Valganciclovir affects sensorineural hearing loss disorder,1922,IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.,"Is the triple ""Valganciclovir affects sensorineural hearing loss disorder"" supported by the sentence: ""IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.""?",False, -20121657,Valganciclovir disrupts cytomegalovirus infection,1923,"CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.","Is the triple ""Valganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.""?",False, -12085189,Valganciclovir prevents sensorineural hearing loss disorder,1924,"We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.","Is the triple ""Valganciclovir prevents sensorineural hearing loss disorder"" supported by the sentence: ""We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.""?",False, -11282399,Valganciclovir prevents cytomegalovirus infection,1925,"These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.","Is the triple ""Valganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.""?",False, -23156448,Valganciclovir predisposes kidney disorder,1926,"CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?","Is the triple ""Valganciclovir predisposes kidney disorder"" supported by the sentence: ""CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?""?",False, -20121656,Valganciclovir predisposes cytomegalovirus infection,1927,Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.,"Is the triple ""Valganciclovir predisposes cytomegalovirus infection"" supported by the sentence: ""Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.""?",False, -24607675,Remdesivir prevents adult acute respiratory distress syndrome,1928,Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.,"Is the triple ""Remdesivir prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.""?",False, -18302878,Pixantrone related to Deoxyribonucleic acid,1929,"The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.","Is the triple ""Pixantrone related to Deoxyribonucleic acid"" supported by the sentence: ""The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.""?",False, -19964229,Amrubicin affects small cell lung carcinoma,1930,"However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.","Is the triple ""Amrubicin affects small cell lung carcinoma"" supported by the sentence: ""However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.""?",False, -15413207,Amrubicin disrupts neoplasm,1931,"Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.","Is the triple ""Amrubicin disrupts neoplasm"" supported by the sentence: ""Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.""?",False, -16523835,Sevoflurane related to delirium,1932,"Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.","Is the triple ""Sevoflurane related to delirium"" supported by the sentence: ""Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.""?",False, -24969850,Sevoflurane causes adult acute respiratory distress syndrome,1933,This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.,"Is the triple ""Sevoflurane causes adult acute respiratory distress syndrome"" supported by the sentence: ""This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.""?",False, -24682900,Sevoflurane causes acute kidney failure,1934,The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.,"Is the triple ""Sevoflurane causes acute kidney failure"" supported by the sentence: ""The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.""?",False, -18232524,Sevoflurane causes Inflammation,1935,"The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.","Is the triple ""Sevoflurane causes Inflammation"" supported by the sentence: ""The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.""?",False, -17508909,Sevoflurane causes brain injury,1936,These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.,"Is the triple ""Sevoflurane causes brain injury"" supported by the sentence: ""These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.""?",False, -17459839,Sevoflurane causes ischemia reperfusion injury,1937,"BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).","Is the triple ""Sevoflurane causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).""?",False, -11419059,Sevoflurane causes delirium,1938,"Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.","Is the triple ""Sevoflurane causes delirium"" supported by the sentence: ""Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.""?",False, -7326848,Sevoflurane causes Pain,1939,"Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.","Is the triple ""Sevoflurane causes Pain"" supported by the sentence: ""Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.""?",False, -25308865,Sevoflurane affects neoplasm,1940,"Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.","Is the triple ""Sevoflurane affects neoplasm"" supported by the sentence: ""Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.""?",False, -25006055,Sevoflurane affects Pain,1941,Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.,"Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.""?",False, -21710900,Sevoflurane affects obesity disorder,1942,"To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.","Is the triple ""Sevoflurane affects obesity disorder"" supported by the sentence: ""To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.""?",False, -18602416,Sevoflurane affects delirium,1943,The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.,"Is the triple ""Sevoflurane affects delirium"" supported by the sentence: ""The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.""?",False, -17685948,Sevoflurane affects Pain,1944,"Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.","Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.""?",False, -17508906,Sevoflurane affects brain injury,1945,We investigated the effects of sevoflurane on EMP-induced brain injury.,"Is the triple ""Sevoflurane affects brain injury"" supported by the sentence: ""We investigated the effects of sevoflurane on EMP-induced brain injury.""?",False, -13563816,Sevoflurane affects Inflammation,1946,The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.,"Is the triple ""Sevoflurane affects Inflammation"" supported by the sentence: ""The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.""?",False, -7303814,Sevoflurane affects ischemia reperfusion injury,1947,"Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.","Is the triple ""Sevoflurane affects ischemia reperfusion injury"" supported by the sentence: ""Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.""?",False, -22571416,Sevoflurane disrupts myocardial infarction,1948,RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.,"Is the triple ""Sevoflurane disrupts myocardial infarction"" supported by the sentence: ""RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.""?",False, -22138617,Sevoflurane disrupts brain injury,1949,These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.,"Is the triple ""Sevoflurane disrupts brain injury"" supported by the sentence: ""These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.""?",False, -19949689,Sevoflurane disrupts ischemia reperfusion injury,1950,"New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.","Is the triple ""Sevoflurane disrupts ischemia reperfusion injury"" supported by the sentence: ""New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.""?",False, -17977822,Sevoflurane disrupts Inflammation,1951,Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.,"Is the triple ""Sevoflurane disrupts Inflammation"" supported by the sentence: ""Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.""?",False, -24348187,Sevoflurane prevents acute kidney failure,1952,Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.,"Is the triple ""Sevoflurane prevents acute kidney failure"" supported by the sentence: ""Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.""?",False, -24204877,Sevoflurane prevents neoplasm,1953,"BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.","Is the triple ""Sevoflurane prevents neoplasm"" supported by the sentence: ""BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.""?",False, -20028749,Sevoflurane prevents delirium,1954,Sevoflurane might be beneficial for reducing delirium and POCD.,"Is the triple ""Sevoflurane prevents delirium"" supported by the sentence: ""Sevoflurane might be beneficial for reducing delirium and POCD.""?",False, -19290567,Sevoflurane prevents Pain,1955,"CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.","Is the triple ""Sevoflurane prevents Pain"" supported by the sentence: ""CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.""?",False, -16830216,Sevoflurane prevents Inflammation,1956,This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.,"Is the triple ""Sevoflurane prevents Inflammation"" supported by the sentence: ""This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.""?",False, -11671117,Sevoflurane prevents brain injury,1957,Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.,"Is the triple ""Sevoflurane prevents brain injury"" supported by the sentence: ""Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.""?",False, -9664903,Sevoflurane prevents ischemia reperfusion injury,1958,BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.,"Is the triple ""Sevoflurane prevents ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.""?",False, -18320093,Sevoflurane predisposes delirium,1959,"Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.","Is the triple ""Sevoflurane predisposes delirium"" supported by the sentence: ""Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.""?",False, -18121347,Sevoflurane predisposes Inflammation,1960,Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.,"Is the triple ""Sevoflurane predisposes Inflammation"" supported by the sentence: ""Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.""?",False, -24455592,Desflurane causes Postoperative Complications,1961,Desflurane resulted in fewer postoperative complications.,"Is the triple ""Desflurane causes Postoperative Complications"" supported by the sentence: ""Desflurane resulted in fewer postoperative complications.""?",False, -16095968,Heroin related to heroin dependence,1962,The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.,"Is the triple ""Heroin related to heroin dependence"" supported by the sentence: ""The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.""?",False, -9440915,Heroin related to opiate dependence,1963,"This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.","Is the triple ""Heroin related to opiate dependence"" supported by the sentence: ""This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.""?",False, -18531996,Heroin causes heroin dependence,1964,"Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.","Is the triple ""Heroin causes heroin dependence"" supported by the sentence: ""Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.""?",False, -14784390,Heroin causes opiate dependence,1965,A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.,"Is the triple ""Heroin causes opiate dependence"" supported by the sentence: ""A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.""?",False, -19449218,Aluminum hydroxide related to type 1 diabetes mellitus,1966,Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.,"Is the triple ""Aluminum hydroxide related to type 1 diabetes mellitus"" supported by the sentence: ""Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.""?",False, -19135529,Aluminum hydroxide related to malaria,1967,METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.,"Is the triple ""Aluminum hydroxide related to malaria"" supported by the sentence: ""METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.""?",False, -18758930,Aluminum hydroxide related to influenza,1968,Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.,"Is the triple ""Aluminum hydroxide related to influenza"" supported by the sentence: ""Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.""?",False, -15398111,Aluminum hydroxide prevents stomatitis,1969,This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).,"Is the triple ""Aluminum hydroxide prevents stomatitis"" supported by the sentence: ""This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).""?",False, -15812884,Methadone related to heroin dependence,1970,Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.,"Is the triple ""Methadone related to heroin dependence"" supported by the sentence: ""Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.""?",False, -19260564,Methadone causes neonatal abstinence syndrome,1971,"Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.","Is the triple ""Methadone causes neonatal abstinence syndrome"" supported by the sentence: ""Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.""?",False, -18130331,Methadone causes neuralgia,1972,We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.,"Is the triple ""Methadone causes neuralgia"" supported by the sentence: ""We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.""?",False, -18100345,Methadone causes Pain,1973,Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.,"Is the triple ""Methadone causes Pain"" supported by the sentence: ""Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.""?",False, -21405277,Methadone affects opiate dependence,1974,"Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).","Is the triple ""Methadone affects opiate dependence"" supported by the sentence: ""Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).""?",False, -21075382,Methadone affects neoplasm,1975,The analgesic drug methadone is able to sensitize various tumors to chemotherapy.,"Is the triple ""Methadone affects neoplasm"" supported by the sentence: ""The analgesic drug methadone is able to sensitize various tumors to chemotherapy.""?",False, -20010980,Methadone affects Premature birth,1976,They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.,"Is the triple ""Methadone affects Premature birth"" supported by the sentence: ""They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.""?",False, -18302283,Methadone affects Pain,1977,"There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.","Is the triple ""Methadone affects Pain"" supported by the sentence: ""There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.""?",False, -18207522,Methadone affects neonatal abstinence syndrome,1978,"The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.","Is the triple ""Methadone affects neonatal abstinence syndrome"" supported by the sentence: ""The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.""?",False, -18078354,Methadone affects cocaine dependence,1979,"Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.","Is the triple ""Methadone affects cocaine dependence"" supported by the sentence: ""Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.""?",False, -11558529,Methadone affects HIV infectious disease,1980,"OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.","Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.""?",False, -9289228,Methadone affects HIV infectious disease,1981,Methadone enhances human immunodeficiency virus infection of human immune cells.,"Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""Methadone enhances human immunodeficiency virus infection of human immune cells.""?",False, -8979183,Methadone affects neuralgia,1982,Studies are on going to assess the potential role of methadone in treating neuropathic pain.,"Is the triple ""Methadone affects neuralgia"" supported by the sentence: ""Studies are on going to assess the potential role of methadone in treating neuropathic pain.""?",False, -16059875,Methadone disrupts neonatal abstinence syndrome,1983,"Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.","Is the triple ""Methadone disrupts neonatal abstinence syndrome"" supported by the sentence: ""Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.""?",False, -10769844,Methadone disrupts Pain,1984,"However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.","Is the triple ""Methadone disrupts Pain"" supported by the sentence: ""However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.""?",False, -17766557,Methadone prevents hepatitis C virus infection,1985,There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.,"Is the triple ""Methadone prevents hepatitis C virus infection"" supported by the sentence: ""There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.""?",False, -15264750,Methadone prevents opiate dependence,1986,Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.,"Is the triple ""Methadone prevents opiate dependence"" supported by the sentence: ""Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.""?",False, -8905283,Methadone prevents Pain,1987,"In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.","Is the triple ""Methadone prevents Pain"" supported by the sentence: ""In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.""?",False, -8022918,Methadone prevents neonatal abstinence syndrome,1988,Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.,"Is the triple ""Methadone prevents neonatal abstinence syndrome"" supported by the sentence: ""Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.""?",False, -26487110,Methadone predisposes HIV infectious disease,1989,"A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.","Is the triple ""Methadone predisposes HIV infectious disease"" supported by the sentence: ""A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.""?",False, -15424591,Methadone predisposes neonatal abstinence syndrome,1990,CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.,"Is the triple ""Methadone predisposes neonatal abstinence syndrome"" supported by the sentence: ""CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.""?",False, -14491460,Methadone predisposes Premature birth,1991,"CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.","Is the triple ""Methadone predisposes Premature birth"" supported by the sentence: ""CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.""?",False, -26386166,Levomethadyl acetate causes opiate dependence,1992,"Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.","Is the triple ""Levomethadyl acetate causes opiate dependence"" supported by the sentence: ""Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.""?",False, -26901861,Halofantrine prevents malaria,1993,Postexposure administration of halofantrine for the prevention of malaria.,"Is the triple ""Halofantrine prevents malaria"" supported by the sentence: ""Postexposure administration of halofantrine for the prevention of malaria.""?",False, -27668107,Erythropoietin related to HIV infectious disease,1994,"Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.","Is the triple ""Erythropoietin related to HIV infectious disease"" supported by the sentence: ""Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.""?",False, -24695634,Erythropoietin related to optic nerve disorder,1995,Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.,"Is the triple ""Erythropoietin related to optic nerve disorder"" supported by the sentence: ""Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.""?",False, -21186290,Erythropoietin related to Premature birth,1996,"To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.","Is the triple ""Erythropoietin related to Premature birth"" supported by the sentence: ""To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.""?",False, -20871066,Erythropoietin related to necrotizing enterocolitis,1997,"The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.","Is the triple ""Erythropoietin related to necrotizing enterocolitis"" supported by the sentence: ""The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.""?",False, -18130124,Erythropoietin related to mood disorder,1998,Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.,"Is the triple ""Erythropoietin related to mood disorder"" supported by the sentence: ""Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.""?",False, -17186873,Erythropoietin related to ST-elevation myocardial infarction,1999,High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.,"Is the triple ""Erythropoietin related to ST-elevation myocardial infarction"" supported by the sentence: ""High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.""?",False, -16980950,Erythropoietin related to acute myeloid leukemia,2000,The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.,"Is the triple ""Erythropoietin related to acute myeloid leukemia"" supported by the sentence: ""The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.""?",False, -16468663,Erythropoietin related to optic neuritis,2001,"A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.","Is the triple ""Erythropoietin related to optic neuritis"" supported by the sentence: ""A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.""?",False, -16173384,Erythropoietin related to Friedreich ataxia,2002,Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.,"Is the triple ""Erythropoietin related to Friedreich ataxia"" supported by the sentence: ""Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.""?",False, -15054484,Erythropoietin related to breast neoplasm,2003,"EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.","Is the triple ""Erythropoietin related to breast neoplasm"" supported by the sentence: ""EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.""?",False, -14004775,Erythropoietin related to malaria,2004,"To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.","Is the triple ""Erythropoietin related to malaria"" supported by the sentence: ""To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.""?",False, -13955435,Erythropoietin related to chronic renal failure syndrome,2005,[Erythropoietin in the treatment of anemia in chronic renal insufficiency].,"Is the triple ""Erythropoietin related to chronic renal failure syndrome"" supported by the sentence: ""[Erythropoietin in the treatment of anemia in chronic renal insufficiency].""?",False, -13624052,Erythropoietin related to stroke disorder,2006,"Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.","Is the triple ""Erythropoietin related to stroke disorder"" supported by the sentence: ""Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.""?",False, -13580694,Erythropoietin related to Fatigue,2007,Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).,"Is the triple ""Erythropoietin related to Fatigue"" supported by the sentence: ""Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).""?",False, -13206114,Erythropoietin related to sickle cell anemia,2008,Erythropoietin for anemia of renal failure in sickle cell disease.,"Is the triple ""Erythropoietin related to sickle cell anemia"" supported by the sentence: ""Erythropoietin for anemia of renal failure in sickle cell disease.""?",False, -12496787,Erythropoietin related to subarachnoid hemorrhage,2009,Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.,"Is the triple ""Erythropoietin related to subarachnoid hemorrhage"" supported by the sentence: ""Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.""?",False, -12188394,Erythropoietin related to Parkinson disease,2010,"These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.","Is the triple ""Erythropoietin related to Parkinson disease"" supported by the sentence: ""These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.""?",False, -12126135,Erythropoietin related to spinal cord injury,2011,We determined whether EPO and MPSS act synergistically in SCI.,"Is the triple ""Erythropoietin related to spinal cord injury"" supported by the sentence: ""We determined whether EPO and MPSS act synergistically in SCI.""?",False, -11923140,Erythropoietin related to acute kidney failure,2012,Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.,"Is the triple ""Erythropoietin related to acute kidney failure"" supported by the sentence: ""Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.""?",False, -11799479,Erythropoietin related to myocardial infarction,2013,A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.,"Is the triple ""Erythropoietin related to myocardial infarction"" supported by the sentence: ""A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.""?",False, -11734187,Erythropoietin related to multiple sclerosis,2014,Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.,"Is the triple ""Erythropoietin related to multiple sclerosis"" supported by the sentence: ""Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.""?",False, -11580074,Erythropoietin related to ischemia reperfusion injury,2015,We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.,"Is the triple ""Erythropoietin related to ischemia reperfusion injury"" supported by the sentence: ""We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.""?",False, -11529882,Erythropoietin related to myocardial ischemia,2016,"To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.","Is the triple ""Erythropoietin related to myocardial ischemia"" supported by the sentence: ""To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.""?",False, -11452051,Erythropoietin related to prostate cancer,2017,These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.,"Is the triple ""Erythropoietin related to prostate cancer"" supported by the sentence: ""These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.""?",False, -11316441,Erythropoietin related to Ischemic stroke,2018,The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.,"Is the triple ""Erythropoietin related to Ischemic stroke"" supported by the sentence: ""The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.""?",False, -11293850,Erythropoietin related to amyotrophic lateral sclerosis,2019,"Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.","Is the triple ""Erythropoietin related to amyotrophic lateral sclerosis"" supported by the sentence: ""Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.""?",False, -10879812,Erythropoietin related to hepatitis C virus infection,2020,Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.,"Is the triple ""Erythropoietin related to hepatitis C virus infection"" supported by the sentence: ""Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.""?",False, -10348029,Erythropoietin related to neoplasm,2021,We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.,"Is the triple ""Erythropoietin related to neoplasm"" supported by the sentence: ""We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.""?",False, -9392178,Erythropoietin related to injury,2022,Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.,"Is the triple ""Erythropoietin related to injury"" supported by the sentence: ""Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.""?",False, -9089666,Erythropoietin related to chronic myelomonocytic leukemia,2023,Response to erythropoietin in chronic myelomonocytic leukaemia.,"Is the triple ""Erythropoietin related to chronic myelomonocytic leukemia"" supported by the sentence: ""Response to erythropoietin in chronic myelomonocytic leukaemia.""?",False, -8164061,Erythropoietin related to myelodysplastic syndrome,2024,"We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.","Is the triple ""Erythropoietin related to myelodysplastic syndrome"" supported by the sentence: ""We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.""?",False, -7458321,Erythropoietin related to brain ischemia,2025,A potential role for erythropoietin in focal permanent cerebral ischemia in mice.,"Is the triple ""Erythropoietin related to brain ischemia"" supported by the sentence: ""A potential role for erythropoietin in focal permanent cerebral ischemia in mice.""?",False, -7310369,Erythropoietin related to anemia,2026,"The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.","Is the triple ""Erythropoietin related to anemia"" supported by the sentence: ""The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.""?",False, -7231907,Erythropoietin related to chronic kidney disease,2027,Drug usage evaluation of epoetin in chronic renal failure.,"Is the triple ""Erythropoietin related to chronic kidney disease"" supported by the sentence: ""Drug usage evaluation of epoetin in chronic renal failure.""?",False, -7137476,Erythropoietin related to kidney failure,2028,This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.,"Is the triple ""Erythropoietin related to kidney failure"" supported by the sentence: ""This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.""?",False, -12479345,Erythropoietin has part myelodysplastic syndrome,2029,"An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.","Is the triple ""Erythropoietin has part myelodysplastic syndrome"" supported by the sentence: ""An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.""?",False, -9398172,Erythropoietin has part neoplasm,2030,"Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.","Is the triple ""Erythropoietin has part neoplasm"" supported by the sentence: ""Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.""?",False, -27259307,Erythropoietin causes acute kidney failure,2031,"To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.","Is the triple ""Erythropoietin causes acute kidney failure"" supported by the sentence: ""To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.""?",False, -20985522,Erythropoietin causes ischemia reperfusion injury,2032,"RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.","Is the triple ""Erythropoietin causes ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.""?",False, -19282478,Erythropoietin causes neoplasm,2033,"Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.","Is the triple ""Erythropoietin causes neoplasm"" supported by the sentence: ""Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.""?",False, -19178150,Erythropoietin causes spinal cord injury,2034,"AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.","Is the triple ""Erythropoietin causes spinal cord injury"" supported by the sentence: ""AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.""?",False, -18508111,Erythropoietin causes Parkinson disease,2035,"The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.","Is the triple ""Erythropoietin causes Parkinson disease"" supported by the sentence: ""The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.""?",False, -16355442,Erythropoietin causes brain ischemia,2036,"Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.","Is the triple ""Erythropoietin causes brain ischemia"" supported by the sentence: ""Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.""?",False, -15387266,Erythropoietin causes stroke disorder,2037,Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.,"Is the triple ""Erythropoietin causes stroke disorder"" supported by the sentence: ""Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.""?",False, -13935957,Erythropoietin causes injury,2038,OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.,"Is the triple ""Erythropoietin causes injury"" supported by the sentence: ""OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.""?",False, -12824447,Erythropoietin causes chronic kidney disease,2039,"BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.","Is the triple ""Erythropoietin causes chronic kidney disease"" supported by the sentence: ""BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.""?",False, -11912976,Erythropoietin causes myocardial infarction,2040,"Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).","Is the triple ""Erythropoietin causes myocardial infarction"" supported by the sentence: ""Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).""?",False, -11763164,Erythropoietin causes Fatigue,2041,"The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.","Is the triple ""Erythropoietin causes Fatigue"" supported by the sentence: ""The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.""?",False, -9672360,Erythropoietin causes kidney failure,2042,"Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.","Is the triple ""Erythropoietin causes kidney failure"" supported by the sentence: ""Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.""?",False, -9370139,Erythropoietin causes subarachnoid hemorrhage,2043,"A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).","Is the triple ""Erythropoietin causes subarachnoid hemorrhage"" supported by the sentence: ""A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).""?",False, -8009177,Erythropoietin causes anemia,2044,Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.,"Is the triple ""Erythropoietin causes anemia"" supported by the sentence: ""Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.""?",False, -26962810,Erythropoietin affects HIV infectious disease,2045,These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.,"Is the triple ""Erythropoietin affects HIV infectious disease"" supported by the sentence: ""These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.""?",False, -26278974,Erythropoietin affects sickle cell anemia,2046,These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.,"Is the triple ""Erythropoietin affects sickle cell anemia"" supported by the sentence: ""These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.""?",False, -24983690,Erythropoietin affects acute myeloid leukemia,2047,We conclude that both erythropoietin and BPA are appropriately increased in ANLL.,"Is the triple ""Erythropoietin affects acute myeloid leukemia"" supported by the sentence: ""We conclude that both erythropoietin and BPA are appropriately increased in ANLL.""?",False, -20885392,Erythropoietin affects ST-elevation myocardial infarction,2048,Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).,"Is the triple ""Erythropoietin affects ST-elevation myocardial infarction"" supported by the sentence: ""Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).""?",False, -20610677,Erythropoietin affects stroke disorder,2049,"In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.","Is the triple ""Erythropoietin affects stroke disorder"" supported by the sentence: ""In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.""?",False, -18390137,Erythropoietin affects chronic kidney disease,2050,The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.""?",False, -18352546,Erythropoietin affects injury,2051,Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.,"Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.""?",False, -17607901,Erythropoietin affects necrotizing enterocolitis,2052,The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.,"Is the triple ""Erythropoietin affects necrotizing enterocolitis"" supported by the sentence: ""The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.""?",False, -15862945,Erythropoietin affects Ischemic stroke,2053,"To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.","Is the triple ""Erythropoietin affects Ischemic stroke"" supported by the sentence: ""To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.""?",False, -15862785,Erythropoietin affects malaria,2054,"CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.","Is the triple ""Erythropoietin affects malaria"" supported by the sentence: ""CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.""?",False, -15728394,Erythropoietin affects myocardial infarction,2055,"Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.""?",False, -15532613,Erythropoietin affects myocardial infarction,2056,"Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.""?",False, -12937865,Erythropoietin affects anemia,2057,"CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.","Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.""?",False, -12867407,Erythropoietin affects myocardial ischemia,2058,Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.,"Is the triple ""Erythropoietin affects myocardial ischemia"" supported by the sentence: ""Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.""?",False, -11701568,Erythropoietin affects Fatigue,2059,"This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.","Is the triple ""Erythropoietin affects Fatigue"" supported by the sentence: ""This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.""?",False, -11563361,Erythropoietin affects neoplasm,2060,"Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.","Is the triple ""Erythropoietin affects neoplasm"" supported by the sentence: ""Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.""?",False, -10970912,Erythropoietin affects brain injury,2061,BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.,"Is the triple ""Erythropoietin affects brain injury"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.""?",False, -10068762,Erythropoietin affects injury,2062,"Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.","Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.""?",False, -9989127,Erythropoietin affects ischemia reperfusion injury,2063,OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.,"Is the triple ""Erythropoietin affects ischemia reperfusion injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.""?",False, -9392180,Erythropoietin affects spinal cord injury,2064,These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.,"Is the triple ""Erythropoietin affects spinal cord injury"" supported by the sentence: ""These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.""?",False, -8981317,Erythropoietin affects brain ischemia,2065,"When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.","Is the triple ""Erythropoietin affects brain ischemia"" supported by the sentence: ""When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.""?",False, -7400221,Erythropoietin affects chronic kidney disease,2066,Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.""?",False, -7278560,Erythropoietin affects anemia,2067,Erythropoietin elevation in anemia of thermal injury.,"Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""Erythropoietin elevation in anemia of thermal injury.""?",False, -27259305,Erythropoietin produces acute kidney failure,2068,Erythropoietin production in rats with post-ischemic acute renal failure.,"Is the triple ""Erythropoietin produces acute kidney failure"" supported by the sentence: ""Erythropoietin production in rats with post-ischemic acute renal failure.""?",False, -26811591,Erythropoietin produces HIV infectious disease,2069,The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.,"Is the triple ""Erythropoietin produces HIV infectious disease"" supported by the sentence: ""The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.""?",False, -26231858,Erythropoietin produces lymphoma,2070,Renal lymphosarcoma with inappropriate erythropoietin production in a dog.,"Is the triple ""Erythropoietin produces lymphoma"" supported by the sentence: ""Renal lymphosarcoma with inappropriate erythropoietin production in a dog.""?",False, -14673419,Erythropoietin produces myocardial infarction,2071,Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.,"Is the triple ""Erythropoietin produces myocardial infarction"" supported by the sentence: ""Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.""?",False, -11452049,Erythropoietin produces prostate cancer,2072,"To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.","Is the triple ""Erythropoietin produces prostate cancer"" supported by the sentence: ""To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.""?",False, -8829207,Erythropoietin produces neoplasm,2073,The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.,"Is the triple ""Erythropoietin produces neoplasm"" supported by the sentence: ""The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.""?",False, -8032421,Erythropoietin produces chronic renal failure syndrome,2074,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic renal failure syndrome"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, -8032418,Erythropoietin produces chronic kidney disease,2075,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic kidney disease"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, -7919214,Erythropoietin produces anemia,2076,"The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.","Is the triple ""Erythropoietin produces anemia"" supported by the sentence: ""The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.""?",False, -7844664,Erythropoietin produces kidney failure,2077,Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.,"Is the triple ""Erythropoietin produces kidney failure"" supported by the sentence: ""Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.""?",False, -17835656,Erythropoietin disrupts brain injury,2078,"CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.","Is the triple ""Erythropoietin disrupts brain injury"" supported by the sentence: ""CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.""?",False, -17602040,Erythropoietin disrupts Hemorrhage,2079,"CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.","Is the triple ""Erythropoietin disrupts Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.""?",False, -17384804,Erythropoietin disrupts Ischemic stroke,2080,"Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.","Is the triple ""Erythropoietin disrupts Ischemic stroke"" supported by the sentence: ""Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.""?",False, -15027834,Erythropoietin disrupts Fatigue,2081,"In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.","Is the triple ""Erythropoietin disrupts Fatigue"" supported by the sentence: ""In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.""?",False, -13243471,Erythropoietin disrupts chronic kidney disease,2082,"Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).","Is the triple ""Erythropoietin disrupts chronic kidney disease"" supported by the sentence: ""Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).""?",False, -13033535,Erythropoietin disrupts amyotrophic lateral sclerosis,2083,Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.,"Is the triple ""Erythropoietin disrupts amyotrophic lateral sclerosis"" supported by the sentence: ""Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.""?",False, -11253087,Erythropoietin disrupts injury,2084,"Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.","Is the triple ""Erythropoietin disrupts injury"" supported by the sentence: ""Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.""?",False, -8818732,Erythropoietin disrupts anemia,2085,"Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.","Is the triple ""Erythropoietin disrupts anemia"" supported by the sentence: ""Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.""?",False, -22124183,Erythropoietin prevents Premature birth,2086,Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.,"Is the triple ""Erythropoietin prevents Premature birth"" supported by the sentence: ""Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.""?",False, -19522952,Erythropoietin prevents Asphyxia,2087,OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.,"Is the triple ""Erythropoietin prevents Asphyxia"" supported by the sentence: ""OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.""?",False, -17246645,Erythropoietin prevents cerebral palsy,2088,"We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.","Is the triple ""Erythropoietin prevents cerebral palsy"" supported by the sentence: ""We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.""?",False, -16915551,Erythropoietin prevents coronary artery disorder,2089,"Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.","Is the triple ""Erythropoietin prevents coronary artery disorder"" supported by the sentence: ""Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.""?",False, -16468664,Erythropoietin prevents optic neuritis,2090,INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.,"Is the triple ""Erythropoietin prevents optic neuritis"" supported by the sentence: ""INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.""?",False, -16040441,Erythropoietin prevents spinal cord injury,2091,This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.,"Is the triple ""Erythropoietin prevents spinal cord injury"" supported by the sentence: ""This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.""?",False, -15444373,Erythropoietin prevents Parkinson disease,2092,"In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.","Is the triple ""Erythropoietin prevents Parkinson disease"" supported by the sentence: ""In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.""?",False, -14252439,Erythropoietin prevents kidney failure,2093,"The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.","Is the triple ""Erythropoietin prevents kidney failure"" supported by the sentence: ""The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.""?",False, -13347324,Erythropoietin prevents subarachnoid hemorrhage,2094,BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.,"Is the triple ""Erythropoietin prevents subarachnoid hemorrhage"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.""?",False, -13017739,Erythropoietin prevents chronic kidney disease,2095,[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].,"Is the triple ""Erythropoietin prevents chronic kidney disease"" supported by the sentence: ""[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].""?",False, -11480928,Erythropoietin prevents Ischemic stroke,2096,"Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.","Is the triple ""Erythropoietin prevents Ischemic stroke"" supported by the sentence: ""Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.""?",False, -11148609,Erythropoietin prevents myocardial ischemia,2097,"Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.","Is the triple ""Erythropoietin prevents myocardial ischemia"" supported by the sentence: ""Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.""?",False, -11115141,Erythropoietin prevents stroke disorder,2098,"Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.","Is the triple ""Erythropoietin prevents stroke disorder"" supported by the sentence: ""Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.""?",False, -10838253,Erythropoietin prevents necrotizing enterocolitis,2099,Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.,"Is the triple ""Erythropoietin prevents necrotizing enterocolitis"" supported by the sentence: ""Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.""?",False, -10766440,Erythropoietin prevents myocardial infarction,2100,Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.,"Is the triple ""Erythropoietin prevents myocardial infarction"" supported by the sentence: ""Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.""?",False, -10125087,Erythropoietin prevents ischemia reperfusion injury,2101,"HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.","Is the triple ""Erythropoietin prevents ischemia reperfusion injury"" supported by the sentence: ""HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.""?",False, -8434315,Erythropoietin prevents injury,2102,"In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.","Is the triple ""Erythropoietin prevents injury"" supported by the sentence: ""In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.""?",False, -8405867,Erythropoietin prevents brain ischemia,2103,Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.,"Is the triple ""Erythropoietin prevents brain ischemia"" supported by the sentence: ""Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.""?",False, -8369017,Erythropoietin prevents brain injury,2104,Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.,"Is the triple ""Erythropoietin prevents brain injury"" supported by the sentence: ""Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.""?",False, -7400218,Erythropoietin prevents Fatigue,2105,"Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.","Is the triple ""Erythropoietin prevents Fatigue"" supported by the sentence: ""Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.""?",False, -7236347,Erythropoietin prevents anemia,2106,"Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.","Is the triple ""Erythropoietin prevents anemia"" supported by the sentence: ""Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.""?",False, -18610239,Erythropoietin exacerbates injury,2107,"However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.","Is the triple ""Erythropoietin exacerbates injury"" supported by the sentence: ""However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.""?",False, -14126866,Erythropoietin exacerbates anemia,2108,"Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.","Is the triple ""Erythropoietin exacerbates anemia"" supported by the sentence: ""Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.""?",False, -25818939,Erythropoietin predisposes neoplasm,2109,"Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.","Is the triple ""Erythropoietin predisposes neoplasm"" supported by the sentence: ""Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.""?",False, -19869298,Erythropoietin predisposes coronary artery disorder,2110,CONCLUSION: Increased EPO and RDW might be risk factors for CAD.,"Is the triple ""Erythropoietin predisposes coronary artery disorder"" supported by the sentence: ""CONCLUSION: Increased EPO and RDW might be risk factors for CAD.""?",False, -19564296,Erythropoietin predisposes Asphyxia,2111,Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.,"Is the triple ""Erythropoietin predisposes Asphyxia"" supported by the sentence: ""Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.""?",False, -19270398,Erythropoietin predisposes brain injury,2112,"According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.","Is the triple ""Erythropoietin predisposes brain injury"" supported by the sentence: ""According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.""?",False, -18282528,Erythropoietin predisposes chronic kidney disease,2113,"Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.","Is the triple ""Erythropoietin predisposes chronic kidney disease"" supported by the sentence: ""Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.""?",False, -16056103,Erythropoietin predisposes Ischemic stroke,2114,CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.,"Is the triple ""Erythropoietin predisposes Ischemic stroke"" supported by the sentence: ""CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.""?",False, -14483144,Erythropoietin predisposes injury,2115,"METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.","Is the triple ""Erythropoietin predisposes injury"" supported by the sentence: ""METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.""?",False, -12166360,Erythropoietin predisposes kidney failure,2116,Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.,"Is the triple ""Erythropoietin predisposes kidney failure"" supported by the sentence: ""Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.""?",False, -8361116,Erythropoietin predisposes anemia,2117,"Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.","Is the triple ""Erythropoietin predisposes anemia"" supported by the sentence: ""Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.""?",False, -24327196,Daprodustat affects anemia,2118,METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.,"Is the triple ""Daprodustat affects anemia"" supported by the sentence: ""METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.""?",False, -24574810,Daprodustat prevents anemia,2119,Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.,"Is the triple ""Daprodustat prevents anemia"" supported by the sentence: ""Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.""?",False, -19595886,mecobalamin related to vitamin B12 deficiency,2120,Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?,"Is the triple ""mecobalamin related to vitamin B12 deficiency"" supported by the sentence: ""Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?""?",False, -13417310,mecobalamin related to amyotrophic lateral sclerosis,2121,[Clinical trials of ultra-high-dose methylcobalamin in ALS].,"Is the triple ""mecobalamin related to amyotrophic lateral sclerosis"" supported by the sentence: ""[Clinical trials of ultra-high-dose methylcobalamin in ALS].""?",False, -26391120,vitamin B12 related to myocardial infarction,2122,[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].,"Is the triple ""vitamin B12 related to myocardial infarction"" supported by the sentence: ""[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].""?",False, -21860699,vitamin B12 related to type 2 diabetes mellitus,2123,"Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.","Is the triple ""vitamin B12 related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.""?",False, -20662929,vitamin B12 related to non-small cell lung carcinoma,2124,CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.,"Is the triple ""vitamin B12 related to non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.""?",False, -19346996,vitamin B12 related to myocardial ischemia,2125,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""vitamin B12 related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, -12974621,vitamin B12 related to osteoporosis,2126,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""vitamin B12 related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, -10934739,vitamin B12 related to chronic kidney disease,2127,Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.,"Is the triple ""vitamin B12 related to chronic kidney disease"" supported by the sentence: ""Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.""?",False, -10883089,vitamin B12 related to depressive disorder,2128,BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.,"Is the triple ""vitamin B12 related to depressive disorder"" supported by the sentence: ""BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.""?",False, -10658870,vitamin B12 related to psoriasis,2129,Is vitamin B12 of value in psoriasis?,"Is the triple ""vitamin B12 related to psoriasis"" supported by the sentence: ""Is vitamin B12 of value in psoriasis?""?",False, -10535786,vitamin B12 related to atherosclerosis,2130,Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.,"Is the triple ""vitamin B12 related to atherosclerosis"" supported by the sentence: ""Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.""?",False, -10535188,vitamin B12 related to lymphoma,2131,Serum vitamin B12 in leukemias and malignant lymphomas.,"Is the triple ""vitamin B12 related to lymphoma"" supported by the sentence: ""Serum vitamin B12 in leukemias and malignant lymphomas.""?",False, -10508686,vitamin B12 related to vitamin B12 deficiency,2132,[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].,"Is the triple ""vitamin B12 related to vitamin B12 deficiency"" supported by the sentence: ""[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].""?",False, -10438501,vitamin B12 related to iron deficiency anemia,2133,Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.,"Is the triple ""vitamin B12 related to iron deficiency anemia"" supported by the sentence: ""Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.""?",False, -9977774,vitamin B12 related to psychotic disorder,2134,Letter: Vitamin B12 in late-onset psychosis of childhood.,"Is the triple ""vitamin B12 related to psychotic disorder"" supported by the sentence: ""Letter: Vitamin B12 in late-onset psychosis of childhood.""?",False, -9644935,vitamin B12 related to anemia,2135,"However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.","Is the triple ""vitamin B12 related to anemia"" supported by the sentence: ""However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.""?",False, -9118739,vitamin B12 related to Low back pain,2136,"Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.","Is the triple ""vitamin B12 related to Low back pain"" supported by the sentence: ""Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.""?",False, -8678107,vitamin B12 related to Alzheimer disease,2137,"Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.","Is the triple ""vitamin B12 related to Alzheimer disease"" supported by the sentence: ""Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.""?",False, -27330642,vitamin B12 causes depressive disorder,2138,"Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.","Is the triple ""vitamin B12 causes depressive disorder"" supported by the sentence: ""Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.""?",False, -26003936,vitamin B12 causes diabetic neuropathy,2139,Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?,"Is the triple ""vitamin B12 causes diabetic neuropathy"" supported by the sentence: ""Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?""?",False, -17687811,vitamin B12 causes osteoporosis,2140,"In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.","Is the triple ""vitamin B12 causes osteoporosis"" supported by the sentence: ""In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.""?",False, -11993792,vitamin B12 causes Reduced blood folate concentration,2141,RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.,"Is the triple ""vitamin B12 causes Reduced blood folate concentration"" supported by the sentence: ""RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.""?",False, -10806959,vitamin B12 causes psychotic disorder,2142,"Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.","Is the triple ""vitamin B12 causes psychotic disorder"" supported by the sentence: ""Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.""?",False, -10716413,vitamin B12 causes vitamin B12 deficiency,2143,[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].,"Is the triple ""vitamin B12 causes vitamin B12 deficiency"" supported by the sentence: ""[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].""?",False, -9828196,vitamin B12 causes anemia,2144,Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.,"Is the triple ""vitamin B12 causes anemia"" supported by the sentence: ""Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.""?",False, -7900732,vitamin B12 causes atherosclerosis,2145,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""vitamin B12 causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, -25091008,vitamin B12 affects HIV infectious disease,2146,"Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.","Is the triple ""vitamin B12 affects HIV infectious disease"" supported by the sentence: ""Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.""?",False, -20098295,vitamin B12 affects depressive disorder,2147,"At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.""?",False, -19763864,vitamin B12 affects Alzheimer disease,2148,"This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.","Is the triple ""vitamin B12 affects Alzheimer disease"" supported by the sentence: ""This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.""?",False, -18490813,vitamin B12 affects depressive disorder,2149,"In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.""?",False, -17348852,vitamin B12 affects vitamin B12 deficiency,2150,"Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.","Is the triple ""vitamin B12 affects vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.""?",False, -16930257,vitamin B12 affects amyotrophic lateral sclerosis,2151,"Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.","Is the triple ""vitamin B12 affects amyotrophic lateral sclerosis"" supported by the sentence: ""Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.""?",False, -13607058,vitamin B12 affects depressive disorder,2152,"Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.""?",False, -12773836,vitamin B12 affects atherosclerosis,2153,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""vitamin B12 affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, -11945900,vitamin B12 affects Pregnancy,2154,"RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.""?",False, -11927611,vitamin B12 affects diabetic neuropathy,2155,"However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.","Is the triple ""vitamin B12 affects diabetic neuropathy"" supported by the sentence: ""However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.""?",False, -10798681,vitamin B12 affects type 2 diabetes mellitus,2156,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""vitamin B12 affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, -10424959,vitamin B12 affects anemia,2157,[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].,"Is the triple ""vitamin B12 affects anemia"" supported by the sentence: ""[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].""?",False, -8733280,vitamin B12 affects Pregnancy,2158,"The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.""?",False, -8015838,vitamin B12 affects chronic kidney disease,2159,Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.,"Is the triple ""vitamin B12 affects chronic kidney disease"" supported by the sentence: ""Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.""?",False, -23636866,vitamin B12 produces vitamin B12 deficiency,2160,"Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.","Is the triple ""vitamin B12 produces vitamin B12 deficiency"" supported by the sentence: ""Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.""?",False, -11124683,vitamin B12 disrupts chronic kidney disease,2161,"CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.","Is the triple ""vitamin B12 disrupts chronic kidney disease"" supported by the sentence: ""CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.""?",False, -20603701,vitamin B12 prevents Alzheimer disease,2162,"Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.","Is the triple ""vitamin B12 prevents Alzheimer disease"" supported by the sentence: ""Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.""?",False, -14586818,vitamin B12 prevents anemia,2163,"The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.","Is the triple ""vitamin B12 prevents anemia"" supported by the sentence: ""The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.""?",False, -10782972,vitamin B12 prevents atherosclerosis,2164,"Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.","Is the triple ""vitamin B12 prevents atherosclerosis"" supported by the sentence: ""Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.""?",False, -9545669,vitamin B12 prevents vitamin B12 deficiency,2165,Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.,"Is the triple ""vitamin B12 prevents vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.""?",False, -27415421,vitamin B12 predisposes myocardial infarction,2166,"BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).","Is the triple ""vitamin B12 predisposes myocardial infarction"" supported by the sentence: ""BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).""?",False, -21063265,vitamin B12 predisposes depressive disorder,2167,Risk of depression in pregnant women with low-normal serum Vitamin B12.,"Is the triple ""vitamin B12 predisposes depressive disorder"" supported by the sentence: ""Risk of depression in pregnant women with low-normal serum Vitamin B12.""?",False, -20875915,vitamin B12 predisposes chronic kidney disease,2168,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""vitamin B12 predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, -15081186,vitamin B12 predisposes osteoporosis,2169,BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.,"Is the triple ""vitamin B12 predisposes osteoporosis"" supported by the sentence: ""BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.""?",False, -12678935,vitamin B12 predisposes atherosclerosis,2170,"Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.","Is the triple ""vitamin B12 predisposes atherosclerosis"" supported by the sentence: ""Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.""?",False, -12664527,vitamin B12 predisposes Alzheimer disease,2171,"OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.","Is the triple ""vitamin B12 predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.""?",False, -8590188,vitamin B12 predisposes anemia,2172,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""vitamin B12 predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, -22149451,Ipragliflozin affects type 2 diabetes mellitus,2173,"Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.","Is the triple ""Ipragliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.""?",False, -24120079,Ertugliflozin disrupts diabetes mellitus,2174,"Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.","Is the triple ""Ertugliflozin disrupts diabetes mellitus"" supported by the sentence: ""Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.""?",False, -23006843,Empagliflozin related to diabetes mellitus,2175,"We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.","Is the triple ""Empagliflozin related to diabetes mellitus"" supported by the sentence: ""We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.""?",False, -22183651,Empagliflozin related to type 2 diabetes mellitus,2176,Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.,"Is the triple ""Empagliflozin related to type 2 diabetes mellitus"" supported by the sentence: ""Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.""?",False, -24924157,Empagliflozin causes non-alcoholic fatty liver disease,2177,This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.,"Is the triple ""Empagliflozin causes non-alcoholic fatty liver disease"" supported by the sentence: ""This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.""?",False, -23515975,Empagliflozin causes myocardial infarction,2178,"METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).","Is the triple ""Empagliflozin causes myocardial infarction"" supported by the sentence: ""METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).""?",False, -23240834,Empagliflozin causes acute kidney failure,2179,Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.,"Is the triple ""Empagliflozin causes acute kidney failure"" supported by the sentence: ""Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.""?",False, -25094844,Empagliflozin affects diabetes mellitus,2180,Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.,"Is the triple ""Empagliflozin affects diabetes mellitus"" supported by the sentence: ""Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.""?",False, -24520517,Empagliflozin affects Insulin resistance,2181,Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.,"Is the triple ""Empagliflozin affects Insulin resistance"" supported by the sentence: ""Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.""?",False, -24184835,Empagliflozin affects diabetic kidney disease,2182,"Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.","Is the triple ""Empagliflozin affects diabetic kidney disease"" supported by the sentence: ""Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.""?",False, -24091231,Empagliflozin affects kidney disorder,2183,Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.,"Is the triple ""Empagliflozin affects kidney disorder"" supported by the sentence: ""Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.""?",False, -22935616,Empagliflozin affects non-alcoholic fatty liver disease,2184,"Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.","Is the triple ""Empagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.""?",False, -22175650,Empagliflozin affects acute kidney failure,2185,We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.,"Is the triple ""Empagliflozin affects acute kidney failure"" supported by the sentence: ""We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.""?",False, -22027265,Empagliflozin affects type 2 diabetes mellitus,2186,Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.,"Is the triple ""Empagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.""?",False, -21867589,Empagliflozin affects myocardial infarction,2187,Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.,"Is the triple ""Empagliflozin affects myocardial infarction"" supported by the sentence: ""Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.""?",False, -21618629,Empagliflozin affects pulmonary arterial hypertension,2188,"While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.","Is the triple ""Empagliflozin affects pulmonary arterial hypertension"" supported by the sentence: ""While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.""?",False, -22842915,Empagliflozin disrupts type 2 diabetes mellitus,2189,"AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).","Is the triple ""Empagliflozin disrupts type 2 diabetes mellitus"" supported by the sentence: ""AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).""?",False, -23528682,Empagliflozin prevents myocardial infarction,2190,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Empagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, -23286446,Empagliflozin prevents acute kidney failure,2191,"In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.","Is the triple ""Empagliflozin prevents acute kidney failure"" supported by the sentence: ""In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.""?",False, -24551007,Empagliflozin predisposes acute kidney failure,2192,Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.,"Is the triple ""Empagliflozin predisposes acute kidney failure"" supported by the sentence: ""Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.""?",False, -24497752,Empagliflozin predisposes hypoglycemia,2193,We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.,"Is the triple ""Empagliflozin predisposes hypoglycemia"" supported by the sentence: ""We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.""?",False, -23163444,Empagliflozin predisposes diabetic kidney disease,2194,These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.,"Is the triple ""Empagliflozin predisposes diabetic kidney disease"" supported by the sentence: ""These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.""?",False, -21786786,Dapagliflozin related to Alzheimer disease,2195,"For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.","Is the triple ""Dapagliflozin related to Alzheimer disease"" supported by the sentence: ""For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.""?",False, -23582915,Dapagliflozin causes Weight loss,2196,"RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).","Is the triple ""Dapagliflozin causes Weight loss"" supported by the sentence: ""RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).""?",False, -25156234,Dapagliflozin affects non-alcoholic fatty liver disease,2197,The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.,"Is the triple ""Dapagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.""?",False, -23530734,Dapagliflozin affects Albuminuria,2198,The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.,"Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.""?",False, -23107287,Dapagliflozin affects type 1 diabetes mellitus,2199,"In conclusion, dapagliflozin had a significant effect on type 1 diabetes.","Is the triple ""Dapagliflozin affects type 1 diabetes mellitus"" supported by the sentence: ""In conclusion, dapagliflozin had a significant effect on type 1 diabetes.""?",False, -23072376,Dapagliflozin affects ischemia reperfusion injury,2200,"RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.","Is the triple ""Dapagliflozin affects ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.""?",False, -22916804,Dapagliflozin affects diabetic kidney disease,2201,Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.,"Is the triple ""Dapagliflozin affects diabetic kidney disease"" supported by the sentence: ""Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.""?",False, -22845588,Dapagliflozin affects type 2 diabetes mellitus,2202,This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.,"Is the triple ""Dapagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.""?",False, -22578057,Dapagliflozin affects Albuminuria,2203,"The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).","Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).""?",False, -22163310,Dapagliflozin affects Weight loss,2204,The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.,"Is the triple ""Dapagliflozin affects Weight loss"" supported by the sentence: ""The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.""?",False, -21622453,Dapagliflozin affects atrial fibrillation,2205,Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.,"Is the triple ""Dapagliflozin affects atrial fibrillation"" supported by the sentence: ""Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.""?",False, -25362847,Dapagliflozin disrupts acute kidney failure,2206,"Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).","Is the triple ""Dapagliflozin disrupts acute kidney failure"" supported by the sentence: ""Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).""?",False, -23258105,Dapagliflozin disrupts kidney failure,2207,"In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.","Is the triple ""Dapagliflozin disrupts kidney failure"" supported by the sentence: ""In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.""?",False, -22845589,Dapagliflozin disrupts diabetes mellitus,2208,"Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).","Is the triple ""Dapagliflozin disrupts diabetes mellitus"" supported by the sentence: ""Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).""?",False, -23973238,Dapagliflozin prevents type 2 diabetes mellitus,2209,INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .,"Is the triple ""Dapagliflozin prevents type 2 diabetes mellitus"" supported by the sentence: ""INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .""?",False, -23528684,Dapagliflozin prevents myocardial infarction,2210,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Dapagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, -23138841,Dapagliflozin prevents diabetic kidney disease,2211,"Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.","Is the triple ""Dapagliflozin prevents diabetic kidney disease"" supported by the sentence: ""Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.""?",False, -22845590,Dapagliflozin prevents diabetes mellitus,2212,"CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.","Is the triple ""Dapagliflozin prevents diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.""?",False, -22832530,Dapagliflozin prevents kidney failure,2213,BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.,"Is the triple ""Dapagliflozin prevents kidney failure"" supported by the sentence: ""BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.""?",False, -21513723,Dapagliflozin prevents obesity disorder,2214,"We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.","Is the triple ""Dapagliflozin prevents obesity disorder"" supported by the sentence: ""We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.""?",False, -25236689,Dapagliflozin predisposes kidney failure,2215,"CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.","Is the triple ""Dapagliflozin predisposes kidney failure"" supported by the sentence: ""CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.""?",False, -23072379,Dapagliflozin predisposes myocardial infarction,2216,"Also, the administration of DAPA mitigated the production of myocardial infarction markers.","Is the triple ""Dapagliflozin predisposes myocardial infarction"" supported by the sentence: ""Also, the administration of DAPA mitigated the production of myocardial infarction markers.""?",False, -20833370,Methyldopa related to type 1 diabetes mellitus,2217,"SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.","Is the triple ""Methyldopa related to type 1 diabetes mellitus"" supported by the sentence: ""SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.""?",False, -15433400,Methyldopa related to preeclampsia,2218,"Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.","Is the triple ""Methyldopa related to preeclampsia"" supported by the sentence: ""Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.""?",False, -7364754,Methyldopa related to hypertensive disorder,2219,"[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].","Is the triple ""Methyldopa related to hypertensive disorder"" supported by the sentence: ""[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].""?",False, -25805913,Methyldopa causes hypertensive disorder,2220,Letter: Methyldopa-induced hypertension.,"Is the triple ""Methyldopa causes hypertensive disorder"" supported by the sentence: ""Letter: Methyldopa-induced hypertension.""?",False, -23430063,Methyldopa causes preeclampsia,2221,"The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.","Is the triple ""Methyldopa causes preeclampsia"" supported by the sentence: ""The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.""?",False, -26257846,Methyldopa affects hypertensive disorder,2222,"In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.","Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.""?",False, -10671192,Methyldopa affects hypertensive disorder,2223,A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.,"Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.""?",False, -26170425,Methyldopa prevents hypertensive disorder,2224,Methyldopa decreased the supine hypertension and increased the standing blood pressure.,"Is the triple ""Methyldopa prevents hypertensive disorder"" supported by the sentence: ""Methyldopa decreased the supine hypertension and increased the standing blood pressure.""?",False, -8219214,Methyldopa exacerbates hypertensive disorder,2225,Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.,"Is the triple ""Methyldopa exacerbates hypertensive disorder"" supported by the sentence: ""Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.""?",False, -20611289,Methyldopa predisposes preeclampsia,2226,"There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.","Is the triple ""Methyldopa predisposes preeclampsia"" supported by the sentence: ""There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.""?",False, -19343164,Exemestane related to male breast carcinoma,2227,Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.,"Is the triple ""Exemestane related to male breast carcinoma"" supported by the sentence: ""Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.""?",False, -14849934,Exemestane related to ductal breast carcinoma in situ,2228,CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.,"Is the triple ""Exemestane related to ductal breast carcinoma in situ"" supported by the sentence: ""CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.""?",False, -14694867,Exemestane related to non-small cell lung carcinoma,2229,Further studies are needed to assess the activity of exemestane in NSCLC.,"Is the triple ""Exemestane related to non-small cell lung carcinoma"" supported by the sentence: ""Further studies are needed to assess the activity of exemestane in NSCLC.""?",False, -11511167,Exemestane related to neoplasm,2230,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Exemestane related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, -18732584,Exemestane affects neoplasm,2231,"RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).","Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).""?",False, -14063167,Exemestane affects neoplasm,2232,Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.,"Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.""?",False, -16053578,Exemestane prevents breast neoplasm,2233,"However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.","Is the triple ""Exemestane prevents breast neoplasm"" supported by the sentence: ""However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.""?",False, -20235097,Rivizor disrupts neoplasm,2234,Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.,"Is the triple ""Rivizor disrupts neoplasm"" supported by the sentence: ""Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.""?",False, -24226617,Letrozole related to polycystic ovary syndrome,2235,"Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.","Is the triple ""Letrozole related to polycystic ovary syndrome"" supported by the sentence: ""Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.""?",False, -19925368,Letrozole related to infertility disorder,2236,"OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.","Is the triple ""Letrozole related to infertility disorder"" supported by the sentence: ""OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.""?",False, -13004646,Letrozole related to endometriosis,2237,Letrozole and norethisterone acetate in rectovaginal endometriosis.,"Is the triple ""Letrozole related to endometriosis"" supported by the sentence: ""Letrozole and norethisterone acetate in rectovaginal endometriosis.""?",False, -11511165,Letrozole related to neoplasm,2238,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Letrozole related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, -22485512,Letrozole causes infertility disorder,2239,(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.,"Is the triple ""Letrozole causes infertility disorder"" supported by the sentence: ""(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.""?",False, -17708157,Letrozole causes neoplasm,2240,RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.,"Is the triple ""Letrozole causes neoplasm"" supported by the sentence: ""RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.""?",False, -14659251,Letrozole causes endometriosis,2241,"INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.","Is the triple ""Letrozole causes endometriosis"" supported by the sentence: ""INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.""?",False, -11078418,Letrozole causes polycystic ovary syndrome,2242,Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.,"Is the triple ""Letrozole causes polycystic ovary syndrome"" supported by the sentence: ""Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.""?",False, -10282160,Letrozole causes hypogonadism,2243,"In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.","Is the triple ""Letrozole causes hypogonadism"" supported by the sentence: ""In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.""?",False, -25205942,Letrozole affects ovarian hyperstimulation syndrome,2244,Whether letrozole has a direct effect in reducing OHSS requires further investigation.,"Is the triple ""Letrozole affects ovarian hyperstimulation syndrome"" supported by the sentence: ""Whether letrozole has a direct effect in reducing OHSS requires further investigation.""?",False, -18870552,Letrozole affects Pregnancy,2245,CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.,"Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.""?",False, -18835925,Letrozole affects inflammatory breast carcinoma,2246,"The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.","Is the triple ""Letrozole affects inflammatory breast carcinoma"" supported by the sentence: ""The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.""?",False, -10866444,Letrozole affects Pregnancy,2247,"In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.","Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.""?",False, -7871182,Letrozole affects neoplasm,2248,"The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.","Is the triple ""Letrozole affects neoplasm"" supported by the sentence: ""The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.""?",False, -21352213,Letrozole disrupts Pregnancy,2249,"Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).","Is the triple ""Letrozole disrupts Pregnancy"" supported by the sentence: ""Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).""?",False, -25448977,Letrozole prevents prostate cancer,2250,To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.,"Is the triple ""Letrozole prevents prostate cancer"" supported by the sentence: ""To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.""?",False, -19305611,Letrozole prevents Spontaneous abortion,2251,SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.,"Is the triple ""Letrozole prevents Spontaneous abortion"" supported by the sentence: ""SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.""?",False, -17892609,Letrozole prevents ovarian hyperstimulation syndrome,2252,"Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.","Is the triple ""Letrozole prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.""?",False, -13373696,Letrozole prevents neoplasm,2253,"Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).","Is the triple ""Letrozole prevents neoplasm"" supported by the sentence: ""Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).""?",False, -20363763,Letrozole predisposes ovarian hyperstimulation syndrome,2254,Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.,"Is the triple ""Letrozole predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.""?",False, -19305612,Letrozole predisposes Spontaneous abortion,2255,"MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).","Is the triple ""Letrozole predisposes Spontaneous abortion"" supported by the sentence: ""MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).""?",False, -26765214,Formestane affects neoplasm,2256,"In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.","Is the triple ""Formestane affects neoplasm"" supported by the sentence: ""In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.""?",False, -25526748,Formestane disrupts neoplasm,2257,Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.,"Is the triple ""Formestane disrupts neoplasm"" supported by the sentence: ""Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.""?",False, -13022860,Formestane prevents neoplasm,2258,"Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.","Is the triple ""Formestane prevents neoplasm"" supported by the sentence: ""Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.""?",False, -26325498,Aminoglutethimide affects neoplasm,2259,The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.,"Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.""?",False, -12185634,Aminoglutethimide affects neoplasm,2260,"Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.","Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.""?",False, -22275813,Relugolix related to prostate cancer,2261,Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.,"Is the triple ""Relugolix related to prostate cancer"" supported by the sentence: ""Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.""?",False, -23469407,Relugolix prevents Pain,2262,CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.,"Is the triple ""Relugolix prevents Pain"" supported by the sentence: ""CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.""?",False, -25422975,Abiraterone related to castration-resistant prostate carcinoma,2263,CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.,"Is the triple ""Abiraterone related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.""?",False, -20717678,Abiraterone related to prostate cancer,2264,Abiraterone and spironolactone in prostate cancer: a combination to avoid.,"Is the triple ""Abiraterone related to prostate cancer"" supported by the sentence: ""Abiraterone and spironolactone in prostate cancer: a combination to avoid.""?",False, -16721978,Abiraterone affects prostate cancer,2265,The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.,"Is the triple ""Abiraterone affects prostate cancer"" supported by the sentence: ""The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.""?",False, -15794241,Abiraterone prevents neoplasm,2266,"The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.","Is the triple ""Abiraterone prevents neoplasm"" supported by the sentence: ""The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.""?",False, -19010753,Abiraterone predisposes prostate cancer,2267,"The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.","Is the triple ""Abiraterone predisposes prostate cancer"" supported by the sentence: ""The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.""?",False, -11344546,Finasteride related to acne,2268,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to acne"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, -11344545,Finasteride related to alopecia,2269,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to alopecia"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, -9840638,Finasteride related to prostate cancer,2270,CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.,"Is the triple ""Finasteride related to prostate cancer"" supported by the sentence: ""CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.""?",False, -7359591,Finasteride related to benign prostatic hyperplasia,2271,"CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).","Is the triple ""Finasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).""?",False, -21759063,Finasteride causes benign prostatic hyperplasia,2272,"Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.","Is the triple ""Finasteride causes benign prostatic hyperplasia"" supported by the sentence: ""Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.""?",False, -11694493,Finasteride causes prostate cancer,2273,"The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).","Is the triple ""Finasteride causes prostate cancer"" supported by the sentence: ""The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).""?",False, -11326933,Finasteride affects prostate cancer,2274,The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.,"Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.""?",False, -9873046,Finasteride affects benign prostatic hyperplasia,2275,Indeed the effect of finasteride in BPH was proven in clinical studies.,"Is the triple ""Finasteride affects benign prostatic hyperplasia"" supported by the sentence: ""Indeed the effect of finasteride in BPH was proven in clinical studies.""?",False, -9845785,Finasteride affects alopecia,2276,We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.,"Is the triple ""Finasteride affects alopecia"" supported by the sentence: ""We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.""?",False, -7857572,Finasteride affects prostate cancer,2277,"To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.","Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.""?",False, -21155186,Finasteride disrupts benign prostatic hyperplasia,2278,"Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.","Is the triple ""Finasteride disrupts benign prostatic hyperplasia"" supported by the sentence: ""Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.""?",False, -10949204,Finasteride disrupts prostate cancer,2279,The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.,"Is the triple ""Finasteride disrupts prostate cancer"" supported by the sentence: ""The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.""?",False, -7931250,Finasteride disrupts alopecia,2280,Finasteride can also be used to stop male baldness.,"Is the triple ""Finasteride disrupts alopecia"" supported by the sentence: ""Finasteride can also be used to stop male baldness.""?",False, -11279550,Finasteride prevents benign prostatic hyperplasia,2281,Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.,"Is the triple ""Finasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.""?",False, -8938663,Finasteride prevents alopecia,2282,It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.,"Is the triple ""Finasteride prevents alopecia"" supported by the sentence: ""It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.""?",False, -7857569,Finasteride prevents prostate cancer,2283,Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.,"Is the triple ""Finasteride prevents prostate cancer"" supported by the sentence: ""Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.""?",False, -9840634,Finasteride predisposes prostate cancer,2284,"Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).","Is the triple ""Finasteride predisposes prostate cancer"" supported by the sentence: ""Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).""?",False, -8913536,Finasteride predisposes benign prostatic hyperplasia,2285,"CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.","Is the triple ""Finasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.""?",False, -15677403,Dutasteride related to benign prostatic hyperplasia,2286,"CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.","Is the triple ""Dutasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.""?",False, -14665250,Dutasteride related to prostate cancer,2287,"Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.","Is the triple ""Dutasteride related to prostate cancer"" supported by the sentence: ""Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.""?",False, -22506276,Dutasteride causes prostatitis,2288,Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.,"Is the triple ""Dutasteride causes prostatitis"" supported by the sentence: ""Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.""?",False, -14995448,Dutasteride affects prostate cancer,2289,"Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.","Is the triple ""Dutasteride affects prostate cancer"" supported by the sentence: ""Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.""?",False, -11407079,Dutasteride affects prostatitis,2290,"Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.","Is the triple ""Dutasteride affects prostatitis"" supported by the sentence: ""Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.""?",False, -10333399,Dutasteride affects benign prostatic hyperplasia,2291,"OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.","Is the triple ""Dutasteride affects benign prostatic hyperplasia"" supported by the sentence: ""OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.""?",False, -15838005,Dutasteride disrupts prostate cancer,2292,"BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.","Is the triple ""Dutasteride disrupts prostate cancer"" supported by the sentence: ""BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.""?",False, -16876475,Dutasteride prevents benign prostatic hyperplasia,2293,"On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).","Is the triple ""Dutasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).""?",False, -13018366,Dutasteride prevents alopecia,2294,"CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.","Is the triple ""Dutasteride prevents alopecia"" supported by the sentence: ""CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.""?",False, -12506526,Dutasteride prevents prostate cancer,2295,"Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.","Is the triple ""Dutasteride prevents prostate cancer"" supported by the sentence: ""Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.""?",False, -13749427,Dutasteride predisposes benign prostatic hyperplasia,2296,The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.,"Is the triple ""Dutasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.""?",False, -13628345,Dutasteride predisposes prostate cancer,2297,Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.,"Is the triple ""Dutasteride predisposes prostate cancer"" supported by the sentence: ""Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.""?",False, -23122900,Celecoxib related to Pain,2298,"The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.","Is the triple ""Celecoxib related to Pain"" supported by the sentence: ""The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.""?",False, -20821764,Celecoxib related to prostate cancer,2299,"Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.","Is the triple ""Celecoxib related to prostate cancer"" supported by the sentence: ""Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.""?",False, -14485082,Celecoxib related to castration-resistant prostate carcinoma,2300,"Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.","Is the triple ""Celecoxib related to castration-resistant prostate carcinoma"" supported by the sentence: ""Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.""?",False, -14288130,Celecoxib related to neoplasm,2301,"Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).","Is the triple ""Celecoxib related to neoplasm"" supported by the sentence: ""Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).""?",False, -15210658,Celecoxib related to Cyclooxygenase 2,2302,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, -15210658,Celecoxib related to Cyclooxygenase 2,2303,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, -11056859,Celecoxib coexists with Cyclooxygenase 2,2304,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, -11056859,Celecoxib coexists with Cyclooxygenase 2,2305,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, -19664582,Celecoxib coexists with Cyclooxygenase 2,2306,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, -19664582,Celecoxib coexists with Cyclooxygenase 2,2307,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, -8460221,Celecoxib physically interacts with Cyclooxygenase 2,2308,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, -9140190,Celecoxib physically interacts with Cyclooxygenase 2,2309,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, -22101111,Celecoxib causes Alzheimer disease,2310,"In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).","Is the triple ""Celecoxib causes Alzheimer disease"" supported by the sentence: ""In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).""?",False, -21110777,Celecoxib causes schizophrenia,2311,"We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.","Is the triple ""Celecoxib causes schizophrenia"" supported by the sentence: ""We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.""?",False, -20555672,Celecoxib causes hepatocellular carcinoma,2312,"The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.","Is the triple ""Celecoxib causes hepatocellular carcinoma"" supported by the sentence: ""The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.""?",False, -14478589,Celecoxib causes Inflammation,2313,"In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.","Is the triple ""Celecoxib causes Inflammation"" supported by the sentence: ""In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.""?",False, -14396158,Celecoxib causes neoplasm,2314,"In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.","Is the triple ""Celecoxib causes neoplasm"" supported by the sentence: ""In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.""?",False, -13894212,Celecoxib causes peptic ulcer disease,2315,"AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.","Is the triple ""Celecoxib causes peptic ulcer disease"" supported by the sentence: ""AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.""?",False, -13829410,Celecoxib causes Pain,2316,"Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.","Is the triple ""Celecoxib causes Pain"" supported by the sentence: ""Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.""?",False, -12882318,Celecoxib causes colorectal neoplasm,2317,"We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.","Is the triple ""Celecoxib causes colorectal neoplasm"" supported by the sentence: ""We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.""?",False, -12147702,Celecoxib causes osteoarthritis,2318,"CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.","Is the triple ""Celecoxib causes osteoarthritis"" supported by the sentence: ""CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.""?",False, -12029200,Celecoxib causes Hemorrhage,2319,"Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.","Is the triple ""Celecoxib causes Hemorrhage"" supported by the sentence: ""Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.""?",False, -10018014,Celecoxib causes hypertensive disorder,2320,"A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.","Is the triple ""Celecoxib causes hypertensive disorder"" supported by the sentence: ""A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.""?",False, -25555760,Celecoxib affects postpartum depression,2321,"METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.","Is the triple ""Celecoxib affects postpartum depression"" supported by the sentence: ""METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.""?",False, -21116356,Celecoxib affects major depressive disorder,2322,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Celecoxib affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, -19634803,Celecoxib affects Hemorrhage,2323,Therapy: Celecoxib reduces risk of ulcer bleeding.,"Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""Therapy: Celecoxib reduces risk of ulcer bleeding.""?",False, -18087191,Celecoxib affects breast neoplasm,2324,The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.,"Is the triple ""Celecoxib affects breast neoplasm"" supported by the sentence: ""The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.""?",False, -17669654,Celecoxib affects glioma,2325,Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.,"Is the triple ""Celecoxib affects glioma"" supported by the sentence: ""Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.""?",False, -17634409,Celecoxib affects depressive disorder,2326,Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.,"Is the triple ""Celecoxib affects depressive disorder"" supported by the sentence: ""Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.""?",False, -16787676,Celecoxib affects hypertensive disorder,2327,CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.,"Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.""?",False, -15889622,Celecoxib affects osteoarthritis,2328,"Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.","Is the triple ""Celecoxib affects osteoarthritis"" supported by the sentence: ""Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.""?",False, -13667242,Celecoxib affects obesity disorder,2329,"CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.","Is the triple ""Celecoxib affects obesity disorder"" supported by the sentence: ""CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.""?",False, -13414910,Celecoxib affects Hemorrhage,2330,"We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).","Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).""?",False, -13122831,Celecoxib affects hypertensive disorder,2331,"However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.","Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.""?",False, -12419082,Celecoxib affects neoplasm,2332,"In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.""?",False, -11947530,Celecoxib affects hepatocellular carcinoma,2333,Antitumoral effect of celecoxib in hepatocellular carcinoma.,"Is the triple ""Celecoxib affects hepatocellular carcinoma"" supported by the sentence: ""Antitumoral effect of celecoxib in hepatocellular carcinoma.""?",False, -11444192,Celecoxib affects neoplasm,2334,"Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.""?",False, -11303331,Celecoxib affects non-small cell lung carcinoma,2335,"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.","Is the triple ""Celecoxib affects non-small cell lung carcinoma"" supported by the sentence: ""Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.""?",False, -10337670,Celecoxib affects colorectal neoplasm,2336,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Celecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, -10157341,Celecoxib affects injury,2337,"Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.","Is the triple ""Celecoxib affects injury"" supported by the sentence: ""Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.""?",False, -9967873,Celecoxib affects Palmar-plantar erythrodysesthesia syndrome,2338,Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.,"Is the triple ""Celecoxib affects Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.""?",False, -9574485,Celecoxib affects schizophrenia,2339,"METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.","Is the triple ""Celecoxib affects schizophrenia"" supported by the sentence: ""METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.""?",False, -9038473,Celecoxib affects peptic ulcer disease,2340,"The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.","Is the triple ""Celecoxib affects peptic ulcer disease"" supported by the sentence: ""The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.""?",False, -7841958,Celecoxib affects rheumatoid arthritis,2341,Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.,"Is the triple ""Celecoxib affects rheumatoid arthritis"" supported by the sentence: ""Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.""?",False, -7726669,Celecoxib affects Pain,2342,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Pain"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, -7726668,Celecoxib affects Inflammation,2343,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Inflammation"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, -7264055,Celecoxib affects Cyclooxygenase 2,2344,"Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.""?",False, -11464194,Celecoxib affects Cyclooxygenase 2,2345,"In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.""?",False, -11846592,Celecoxib produces Cyclooxygenase 2,2346,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, -11846592,Celecoxib produces Cyclooxygenase 2,2347,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, -14865798,Celecoxib has input Cyclooxygenase 2,2348,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, -14865798,Celecoxib has input Cyclooxygenase 2,2349,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, -22029254,Celecoxib disrupts major depressive disorder,2350,Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.,"Is the triple ""Celecoxib disrupts major depressive disorder"" supported by the sentence: ""Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.""?",False, -16862201,Celecoxib disrupts hepatocellular carcinoma,2351,"Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.","Is the triple ""Celecoxib disrupts hepatocellular carcinoma"" supported by the sentence: ""Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.""?",False, -15337601,Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome,2352,"RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).","Is the triple ""Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).""?",False, -15029907,Celecoxib disrupts Pain,2353,"RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.","Is the triple ""Celecoxib disrupts Pain"" supported by the sentence: ""RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.""?",False, -14234726,Celecoxib disrupts adenoma,2354,"Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.","Is the triple ""Celecoxib disrupts adenoma"" supported by the sentence: ""Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.""?",False, -12025752,Celecoxib disrupts colonic neoplasm,2355,Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.,"Is the triple ""Celecoxib disrupts colonic neoplasm"" supported by the sentence: ""Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.""?",False, -9589598,Celecoxib disrupts neoplasm,2356,"RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.","Is the triple ""Celecoxib disrupts neoplasm"" supported by the sentence: ""RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.""?",False, -9384934,Celecoxib disrupts breast neoplasm,2357,Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.,"Is the triple ""Celecoxib disrupts breast neoplasm"" supported by the sentence: ""Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.""?",False, -8528907,Celecoxib disrupts Inflammation,2358,"Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).","Is the triple ""Celecoxib disrupts Inflammation"" supported by the sentence: ""Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).""?",False, -19393781,Celecoxib prevents stroke disorder,2359,"Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].","Is the triple ""Celecoxib prevents stroke disorder"" supported by the sentence: ""Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].""?",False, -18309561,Celecoxib prevents hepatocellular carcinoma,2360,"In addition, celecoxib was found to significantly reduce HCC progression.","Is the triple ""Celecoxib prevents hepatocellular carcinoma"" supported by the sentence: ""In addition, celecoxib was found to significantly reduce HCC progression.""?",False, -17468664,Celecoxib prevents non-small cell lung carcinoma,2361,"In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.","Is the triple ""Celecoxib prevents non-small cell lung carcinoma"" supported by the sentence: ""In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.""?",False, -16386169,Celecoxib prevents actinic keratosis,2362,QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?,"Is the triple ""Celecoxib prevents actinic keratosis"" supported by the sentence: ""QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?""?",False, -16323754,Celecoxib prevents hypertensive disorder,2363,"RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.","Is the triple ""Celecoxib prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.""?",False, -15947575,Celecoxib prevents osteoarthritis,2364,"OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.","Is the triple ""Celecoxib prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.""?",False, -15337603,Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome,2365,"CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.","Is the triple ""Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.""?",False, -14688780,Celecoxib prevents Low back pain,2366,RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.,"Is the triple ""Celecoxib prevents Low back pain"" supported by the sentence: ""RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.""?",False, -13346756,Celecoxib prevents prostate cancer,2367,A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.,"Is the triple ""Celecoxib prevents prostate cancer"" supported by the sentence: ""A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.""?",False, -12969778,Celecoxib prevents neuroblastoma,2368,Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.,"Is the triple ""Celecoxib prevents neuroblastoma"" supported by the sentence: ""Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.""?",False, -12687466,Celecoxib prevents adenoma,2369,Risks and benefits of celecoxib to prevent recurrent adenomas.,"Is the triple ""Celecoxib prevents adenoma"" supported by the sentence: ""Risks and benefits of celecoxib to prevent recurrent adenomas.""?",False, -11060421,Celecoxib prevents classic familial adenomatous polyposis,2370,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Celecoxib prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, -10931690,Celecoxib prevents breast neoplasm,2371,"The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.","Is the triple ""Celecoxib prevents breast neoplasm"" supported by the sentence: ""The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.""?",False, -10337661,Celecoxib prevents colorectal neoplasm,2372,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Celecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, -9969498,Celecoxib prevents Acute Pain,2373,"Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.","Is the triple ""Celecoxib prevents Acute Pain"" supported by the sentence: ""Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.""?",False, -9525867,Celecoxib prevents injury,2374,Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.,"Is the triple ""Celecoxib prevents injury"" supported by the sentence: ""Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.""?",False, -9508533,Celecoxib prevents Pain,2375,IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.,"Is the triple ""Celecoxib prevents Pain"" supported by the sentence: ""IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.""?",False, -8844228,Celecoxib prevents Inflammation,2376,"Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.","Is the triple ""Celecoxib prevents Inflammation"" supported by the sentence: ""Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.""?",False, -7720173,Celecoxib prevents neoplasm,2377,The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.,"Is the triple ""Celecoxib prevents neoplasm"" supported by the sentence: ""The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.""?",False, -14426267,Celecoxib predisposes Inflammation,2378,"In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.","Is the triple ""Celecoxib predisposes Inflammation"" supported by the sentence: ""In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.""?",False, -12799788,Celecoxib predisposes hypertensive disorder,2379,"Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.","Is the triple ""Celecoxib predisposes hypertensive disorder"" supported by the sentence: ""Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.""?",False, -11130431,Celecoxib predisposes injury,2380,CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.,"Is the triple ""Celecoxib predisposes injury"" supported by the sentence: ""CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.""?",False, -12352394,Rofecoxib related to Cyclooxygenase 2,2381,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, -12352394,Rofecoxib related to Cyclooxygenase 2,2382,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, -14685035,Rofecoxib related to Cyclooxygenase 2,2383,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, -14685035,Rofecoxib related to Cyclooxygenase 2,2384,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, -8460222,Rofecoxib physically interacts with Cyclooxygenase 2,2385,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, -9140191,Rofecoxib physically interacts with Cyclooxygenase 2,2386,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, -10265772,Rofecoxib causes Pain,2387,We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.,"Is the triple ""Rofecoxib causes Pain"" supported by the sentence: ""We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.""?",False, -13140649,Rofecoxib affects Pain,2388,"Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.","Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.""?",False, -13143485,Rofecoxib affects osteoarthritis,2389,Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).""?",False, -12129893,Rofecoxib affects adenoma,2390,Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.,"Is the triple ""Rofecoxib affects adenoma"" supported by the sentence: ""Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.""?",False, -11539323,Rofecoxib affects Pain,2391,Effect of rofecoxib on pain caused by osteoid osteoma.,"Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Effect of rofecoxib on pain caused by osteoid osteoma.""?",False, -10337671,Rofecoxib affects colorectal neoplasm,2392,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Rofecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, -8436303,Rofecoxib affects osteoarthritis,2393,The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.""?",False, -7546790,Rofecoxib affects Cyclooxygenase 2,2394,"Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.""?",False, -11143316,Rofecoxib affects Cyclooxygenase 2,2395,"Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.""?",False, -11899486,Rofecoxib disrupts Pain,2396,Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.,"Is the triple ""Rofecoxib disrupts Pain"" supported by the sentence: ""Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.""?",False, -12422414,Rofecoxib prevents adenoma,2397,BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.,"Is the triple ""Rofecoxib prevents adenoma"" supported by the sentence: ""BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.""?",False, -10337662,Rofecoxib prevents colorectal neoplasm,2398,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Rofecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, -9488144,Rofecoxib prevents Pain,2399,"This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.","Is the triple ""Rofecoxib prevents Pain"" supported by the sentence: ""This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.""?",False, -12808149,Rofecoxib predisposes adenoma,2400,Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).,"Is the triple ""Rofecoxib predisposes adenoma"" supported by the sentence: ""Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).""?",False, -21440548,Etoricoxib affects osteoarthritis,2401,"In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.","Is the triple ""Etoricoxib affects osteoarthritis"" supported by the sentence: ""In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.""?",False, -17783506,Etoricoxib affects injury,2402,The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.,"Is the triple ""Etoricoxib affects injury"" supported by the sentence: ""The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.""?",False, -15015650,Etoricoxib affects Pain,2403,DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.,"Is the triple ""Etoricoxib affects Pain"" supported by the sentence: ""DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.""?",False, -13276651,Etoricoxib affects rheumatic disorder,2404,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Etoricoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, -8656381,Etoricoxib affects Cyclooxygenase 2,2405,"In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.","Is the triple ""Etoricoxib affects Cyclooxygenase 2"" supported by the sentence: ""In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.""?",False, -21271381,Etoricoxib prevents osteoarthritis,2406,The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.,"Is the triple ""Etoricoxib prevents osteoarthritis"" supported by the sentence: ""The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.""?",False, -17783508,Etoricoxib prevents injury,2407,The results of this study show that etoricoxib treatment could decrease kidney injury during IR.,"Is the triple ""Etoricoxib prevents injury"" supported by the sentence: ""The results of this study show that etoricoxib treatment could decrease kidney injury during IR.""?",False, -13679347,Etoricoxib prevents Pain,2408,CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.,"Is the triple ""Etoricoxib prevents Pain"" supported by the sentence: ""CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.""?",False, -11619190,Lumiracoxib coexists with Cyclooxygenase 2,2409,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, -11619190,Lumiracoxib coexists with Cyclooxygenase 2,2410,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, -17164065,Lumiracoxib physically interacts with Cyclooxygenase 2,2411,The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.,"Is the triple ""Lumiracoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.""?",False, -13276652,Lumiracoxib affects rheumatic disorder,2412,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Lumiracoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, -10245332,Lumiracoxib affects Cyclooxygenase 2,2413,"Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.","Is the triple ""Lumiracoxib affects Cyclooxygenase 2"" supported by the sentence: ""Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.""?",False, -13077914,Valdecoxib physically interacts with Cyclooxygenase 2,2414,We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.,"Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.""?",False, -11476053,Valdecoxib physically interacts with Cyclooxygenase 2,2415,"Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).","Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).""?",False, -9552647,Valdecoxib affects Cyclooxygenase 2,2416,"Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].","Is the triple ""Valdecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].""?",False, -11215677,Valdecoxib disrupts Pain,2417,Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.,"Is the triple ""Valdecoxib disrupts Pain"" supported by the sentence: ""Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.""?",False, -15156435,Valdecoxib prevents pancreatitis,2418,CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.,"Is the triple ""Valdecoxib prevents pancreatitis"" supported by the sentence: ""CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.""?",False, -10035578,Valdecoxib prevents Pain,2419,"Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.","Is the triple ""Valdecoxib prevents Pain"" supported by the sentence: ""Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.""?",False, -17909160,Parecoxib coexists with Cyclooxygenase 2,2420,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, -17909160,Parecoxib coexists with Cyclooxygenase 2,2421,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, -16597136,Parecoxib affects Shoulder pain,2422,BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.,"Is the triple ""Parecoxib affects Shoulder pain"" supported by the sentence: ""BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.""?",False, -13492238,Parecoxib affects Pain,2423,Preventive effects of perioperative parecoxib on post-discectomy pain.,"Is the triple ""Parecoxib affects Pain"" supported by the sentence: ""Preventive effects of perioperative parecoxib on post-discectomy pain.""?",False, -12600950,Parecoxib affects Cyclooxygenase 2,2424,Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.,"Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.""?",False, -18579418,Parecoxib affects Cyclooxygenase 2,2425,"While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).","Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).""?",False, -18207264,Parecoxib disrupts Pain,2426,"Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).","Is the triple ""Parecoxib disrupts Pain"" supported by the sentence: ""Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).""?",False, -16597135,Parecoxib prevents Shoulder pain,2427,"Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.","Is the triple ""Parecoxib prevents Shoulder pain"" supported by the sentence: ""Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.""?",False, -14081775,Parecoxib prevents Pain,2428,RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.,"Is the triple ""Parecoxib prevents Pain"" supported by the sentence: ""RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.""?",False, -22281663,Drospirenone related to polycystic ovary syndrome,2429,"METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.","Is the triple ""Drospirenone related to polycystic ovary syndrome"" supported by the sentence: ""METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.""?",False, -21546756,Drospirenone related to acne,2430,"Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).","Is the triple ""Drospirenone related to acne"" supported by the sentence: ""Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).""?",False, -20964606,Drospirenone predisposes polycystic ovary syndrome,2431,"Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.","Is the triple ""Drospirenone predisposes polycystic ovary syndrome"" supported by the sentence: ""Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.""?",False, -8455182,Ropinirole related to Parkinson disease,2432,Ropinirole as compared with levodopa in Parkinson's disease.,"Is the triple ""Ropinirole related to Parkinson disease"" supported by the sentence: ""Ropinirole as compared with levodopa in Parkinson's disease.""?",False, -17774585,Ropinirole causes Parkinson disease,2433,"Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.","Is the triple ""Ropinirole causes Parkinson disease"" supported by the sentence: ""Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.""?",False, -14587825,Ropinirole affects Parkinson disease,2434,An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.,"Is the triple ""Ropinirole affects Parkinson disease"" supported by the sentence: ""An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.""?",False, -11791368,Ropinirole affects restless legs syndrome,2435,The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.,"Is the triple ""Ropinirole affects restless legs syndrome"" supported by the sentence: ""The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.""?",False, -9334943,Ropinirole disrupts Parkinson disease,2436,"A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).","Is the triple ""Ropinirole disrupts Parkinson disease"" supported by the sentence: ""A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).""?",False, -10286489,Ropinirole prevents Parkinson disease,2437,"Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.","Is the triple ""Ropinirole prevents Parkinson disease"" supported by the sentence: ""Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.""?",False, -27727471,Pergolide related to Parkinson disease,2438,Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.,"Is the triple ""Pergolide related to Parkinson disease"" supported by the sentence: ""Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.""?",False, -11914502,Pergolide causes Parkinson disease,2439,"The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.","Is the triple ""Pergolide causes Parkinson disease"" supported by the sentence: ""The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.""?",False, -10881399,Pergolide affects Parkinson disease,2440,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pergolide affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, -16163315,Bromocriptine related to Parkinson disease,2441,Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.,"Is the triple ""Bromocriptine related to Parkinson disease"" supported by the sentence: ""Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.""?",False, -15233295,Bromocriptine related to type 1 diabetes mellitus,2442,Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.,"Is the triple ""Bromocriptine related to type 1 diabetes mellitus"" supported by the sentence: ""Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.""?",False, -17352665,Bromocriptine causes obesity disorder,2443,"SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.","Is the triple ""Bromocriptine causes obesity disorder"" supported by the sentence: ""SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.""?",False, -12630193,Bromocriptine causes Parkinson disease,2444,"The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.","Is the triple ""Bromocriptine causes Parkinson disease"" supported by the sentence: ""The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.""?",False, -22488533,Bromocriptine affects adenomyosis,2445,The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.,"Is the triple ""Bromocriptine affects adenomyosis"" supported by the sentence: ""The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.""?",False, -20888778,Bromocriptine affects Parkinson disease,2446,"Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.","Is the triple ""Bromocriptine affects Parkinson disease"" supported by the sentence: ""Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.""?",False, -27647530,Bromocriptine prevents obesity disorder,2447,"Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.","Is the triple ""Bromocriptine prevents obesity disorder"" supported by the sentence: ""Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.""?",False, -15529387,Bromocriptine prevents ovarian hyperstimulation syndrome,2448,Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.,"Is the triple ""Bromocriptine prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.""?",False, -18216941,Piribedil causes Parkinson disease,2449,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Piribedil causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, -8408670,Piribedil affects Parkinson disease,2450,Action of piribedil in Parkinson's disease: I.V. test and oral treatment.,"Is the triple ""Piribedil affects Parkinson disease"" supported by the sentence: ""Action of piribedil in Parkinson's disease: I.V. test and oral treatment.""?",False, -8818724,Apomorphine related to Parkinson disease,2451,The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine related to Parkinson disease"" supported by the sentence: ""The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.""?",False, -23018637,Apomorphine causes erectile dysfunction,2452,Apomorphine was used to induce diabetic erectile dysfunction.,"Is the triple ""Apomorphine causes erectile dysfunction"" supported by the sentence: ""Apomorphine was used to induce diabetic erectile dysfunction.""?",False, -11364291,Apomorphine causes Parkinson disease,2453,"Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.","Is the triple ""Apomorphine causes Parkinson disease"" supported by the sentence: ""Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.""?",False, -8320181,Apomorphine affects Parkinson disease,2454,The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine affects Parkinson disease"" supported by the sentence: ""The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.""?",False, -16869339,Cabergoline related to Parkinson disease,2455,OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).,"Is the triple ""Cabergoline related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).""?",False, -19536611,Cabergoline physically interacts with Dopamine D2 Receptor,2456,CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.,"Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.""?",False, -15320456,Cabergoline physically interacts with Dopamine D2 Receptor,2457,"In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.","Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.""?",False, -20751353,Cabergoline causes endometriosis,2458,"Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).","Is the triple ""Cabergoline causes endometriosis"" supported by the sentence: ""Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).""?",False, -26585560,Cabergoline affects pituitary tumor,2459,The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.,"Is the triple ""Cabergoline affects pituitary tumor"" supported by the sentence: ""The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.""?",False, -19237315,Cabergoline affects endometriosis,2460,Effect of Cabergoline in Experimental Endometriosis in Rats.,"Is the triple ""Cabergoline affects endometriosis"" supported by the sentence: ""Effect of Cabergoline in Experimental Endometriosis in Rats.""?",False, -17463083,Cabergoline affects Dopamine D2 Receptor,2461,Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.,"Is the triple ""Cabergoline affects Dopamine D2 Receptor"" supported by the sentence: ""Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.""?",False, -12695381,Cabergoline affects ovarian hyperstimulation syndrome,2462,OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.,"Is the triple ""Cabergoline affects ovarian hyperstimulation syndrome"" supported by the sentence: ""OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.""?",False, -13380476,Cabergoline prevents ovarian hyperstimulation syndrome,2463,Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.,"Is the triple ""Cabergoline prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.""?",False, -9194241,Cabergoline predisposes ovarian hyperstimulation syndrome,2464,"CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.","Is the triple ""Cabergoline predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.""?",False, -15982499,Pramipexole related to restless legs syndrome,2465,"Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.","Is the triple ""Pramipexole related to restless legs syndrome"" supported by the sentence: ""Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.""?",False, -9735890,Pramipexole related to Parkinson disease,2466,Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.,"Is the triple ""Pramipexole related to Parkinson disease"" supported by the sentence: ""Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.""?",False, -21401262,Pramipexole causes restless legs syndrome,2467,Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.,"Is the triple ""Pramipexole causes restless legs syndrome"" supported by the sentence: ""Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.""?",False, -15033700,Pramipexole causes obsessive-compulsive disorder,2468,"CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.","Is the triple ""Pramipexole causes obsessive-compulsive disorder"" supported by the sentence: ""CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.""?",False, -13328857,Pramipexole causes Parkinson disease,2469,"We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.","Is the triple ""Pramipexole causes Parkinson disease"" supported by the sentence: ""We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.""?",False, -18143671,Pramipexole affects depressive disorder,2470,The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.,"Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.""?",False, -12990655,Pramipexole affects restless legs syndrome,2471,The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.,"Is the triple ""Pramipexole affects restless legs syndrome"" supported by the sentence: ""The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.""?",False, -12579916,Pramipexole affects depressive disorder,2472,"Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.","Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.""?",False, -10881401,Pramipexole affects Parkinson disease,2473,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pramipexole affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, -11457313,Pramipexole prevents Parkinson disease,2474,"Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.","Is the triple ""Pramipexole prevents Parkinson disease"" supported by the sentence: ""Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.""?",False, -24610805,Rotigotine affects Parkinson disease,2475,"A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.","Is the triple ""Rotigotine affects Parkinson disease"" supported by the sentence: ""A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.""?",False, -10840977,Norethindrone subclass of Norethindrone acetate,2476,"Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.","Is the triple ""Norethindrone subclass of Norethindrone acetate"" supported by the sentence: ""Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.""?",False, -8232443,Norethindrone related to Norethindrone acetate,2477,"The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.","Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.""?",False, -11686400,Norethindrone related to Norethindrone acetate,2478,OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).,"Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).""?",False, -9474851,Norethindrone coexists with Norethindrone acetate,2479,"The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.","Is the triple ""Norethindrone coexists with Norethindrone acetate"" supported by the sentence: ""The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.""?",False, -9781055,Norethindrone physically interacts with Norethindrone acetate,2480,"Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.","Is the triple ""Norethindrone physically interacts with Norethindrone acetate"" supported by the sentence: ""Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.""?",False, -21462883,Norethindrone causes neoplasm,2481,"Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.","Is the triple ""Norethindrone causes neoplasm"" supported by the sentence: ""Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.""?",False, -27429354,Pramocaine affects Pruritus,2482,Effect of topical pramoxine on experimentally induced pruritus in humans.,"Is the triple ""Pramocaine affects Pruritus"" supported by the sentence: ""Effect of topical pramoxine on experimentally induced pruritus in humans.""?",False, -19275366,Miconazole disrupts fungal infectious disease,2483,"Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.","Is the triple ""Miconazole disrupts fungal infectious disease"" supported by the sentence: ""Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.""?",False, -26511975,Miconazole prevents fungal infectious disease,2484,"The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.","Is the triple ""Miconazole prevents fungal infectious disease"" supported by the sentence: ""The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.""?",False, -26530559,Benzocaine affects Pain,2485,OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.,"Is the triple ""Benzocaine affects Pain"" supported by the sentence: ""OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.""?",False, -8870493,Benzocaine disrupts Pain,2486,CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.,"Is the triple ""Benzocaine disrupts Pain"" supported by the sentence: ""CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.""?",False, -8870496,Benzocaine prevents Pain,2487,"Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.","Is the triple ""Benzocaine prevents Pain"" supported by the sentence: ""Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.""?",False, -25561815,Folic Acid related to systemic lupus erythematosus,2488,Folic acid in systemic lupus erythematosus - a new aspect.,"Is the triple ""Folic Acid related to systemic lupus erythematosus"" supported by the sentence: ""Folic acid in systemic lupus erythematosus - a new aspect.""?",False, -23703706,Folic Acid related to neoplasm of esophagus,2489,"We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.","Is the triple ""Folic Acid related to neoplasm of esophagus"" supported by the sentence: ""We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.""?",False, -23248765,Folic Acid related to chronic renal failure syndrome,2490,"Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.","Is the triple ""Folic Acid related to chronic renal failure syndrome"" supported by the sentence: ""Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.""?",False, -20038856,Folic Acid related to psychotic disorder,2491,Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.,"Is the triple ""Folic Acid related to psychotic disorder"" supported by the sentence: ""Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.""?",False, -19346997,Folic Acid related to myocardial ischemia,2492,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""Folic Acid related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, -19301020,Folic Acid related to type 2 diabetes mellitus,2493,"In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.","Is the triple ""Folic Acid related to type 2 diabetes mellitus"" supported by the sentence: ""In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.""?",False, -19114314,Folic Acid related to tuberculosis,2494,Information about folate status in tuberculosis in developing countries is scanty.,"Is the triple ""Folic Acid related to tuberculosis"" supported by the sentence: ""Information about folate status in tuberculosis in developing countries is scanty.""?",False, -18323097,Folic Acid related to HIV infectious disease,2495,"CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.","Is the triple ""Folic Acid related to HIV infectious disease"" supported by the sentence: ""CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.""?",False, -17591518,Folic Acid related to infertility disorder,2496,Folate is one of the B vitamins which has been suggested to be related to infertility.,"Is the triple ""Folic Acid related to infertility disorder"" supported by the sentence: ""Folate is one of the B vitamins which has been suggested to be related to infertility.""?",False, -15826430,Folic Acid related to male infertility,2497,Folate and vitamin B12 in idiopathic male infertility.,"Is the triple ""Folic Acid related to male infertility"" supported by the sentence: ""Folate and vitamin B12 in idiopathic male infertility.""?",False, -14280104,Folic Acid related to myocardial infarction,2498,"CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.","Is the triple ""Folic Acid related to myocardial infarction"" supported by the sentence: ""CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.""?",False, -12974622,Folic Acid related to osteoporosis,2499,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""Folic Acid related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, -12112288,Folic Acid related to autism spectrum disorder,2500,"Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.","Is the triple ""Folic Acid related to autism spectrum disorder"" supported by the sentence: ""Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.""?",False, -11305980,Folic Acid related to cleft palate,2501,"The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.","Is the triple ""Folic Acid related to cleft palate"" supported by the sentence: ""The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.""?",False, -10745702,Folic Acid related to malaria,2502,Administration of pyrimethamine with folic acid and folinic acids in human malaria.,"Is the triple ""Folic Acid related to malaria"" supported by the sentence: ""Administration of pyrimethamine with folic acid and folinic acids in human malaria.""?",False, -10717915,Folic Acid related to habitual spontaneous abortion,2503,SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.,"Is the triple ""Folic Acid related to habitual spontaneous abortion"" supported by the sentence: ""SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.""?",False, -10644755,Folic Acid related to atherosclerosis,2504,[Use of vitamin B12 and folic acid in atherosclerosis].,"Is the triple ""Folic Acid related to atherosclerosis"" supported by the sentence: ""[Use of vitamin B12 and folic acid in atherosclerosis].""?",False, -10226420,Folic Acid related to cervical polyp,2505,"Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.","Is the triple ""Folic Acid related to cervical polyp"" supported by the sentence: ""Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.""?",False, -10177078,Folic Acid related to colorectal neoplasm,2506,CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.,"Is the triple ""Folic Acid related to colorectal neoplasm"" supported by the sentence: ""CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.""?",False, -10046990,Folic Acid related to depressive disorder,2507,This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.,"Is the triple ""Folic Acid related to depressive disorder"" supported by the sentence: ""This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.""?",False, -9815747,Folic Acid related to hypertensive disorder,2508,"In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.","Is the triple ""Folic Acid related to hypertensive disorder"" supported by the sentence: ""In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.""?",False, -9628243,Folic Acid related to mesothelioma,2509,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to mesothelioma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, -9628242,Folic Acid related to non-small cell lung carcinoma,2510,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to non-small cell lung carcinoma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, -9060030,Folic Acid related to neoplasm,2511,Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.,"Is the triple ""Folic Acid related to neoplasm"" supported by the sentence: ""Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.""?",False, -8875457,Folic Acid related to lymphoma,2512,"The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.","Is the triple ""Folic Acid related to lymphoma"" supported by the sentence: ""The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.""?",False, -8584638,Folic Acid related to sickle cell anemia,2513,Erythrocyte folate does not accurately reflect folate status in sickle cell disease.,"Is the triple ""Folic Acid related to sickle cell anemia"" supported by the sentence: ""Erythrocyte folate does not accurately reflect folate status in sickle cell disease.""?",False, -8274471,Folic Acid related to chronic kidney disease,2514,"In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.","Is the triple ""Folic Acid related to chronic kidney disease"" supported by the sentence: ""In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.""?",False, -8259960,Folic Acid related to type 1 diabetes mellitus,2515,"OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.","Is the triple ""Folic Acid related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.""?",False, -8078141,Folic Acid related to Alzheimer disease,2516,Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.,"Is the triple ""Folic Acid related to Alzheimer disease"" supported by the sentence: ""Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.""?",False, -7868306,Folic Acid related to coronary artery disorder,2517,"In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.","Is the triple ""Folic Acid related to coronary artery disorder"" supported by the sentence: ""In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.""?",False, -7765942,Folic Acid related to anemia,2518,"No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.","Is the triple ""Folic Acid related to anemia"" supported by the sentence: ""No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.""?",False, -7303518,Folic Acid related to epilepsy,2519,"Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.","Is the triple ""Folic Acid related to epilepsy"" supported by the sentence: ""Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.""?",False, -7234301,Folic Acid related to Reduced blood folate concentration,2520,Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.,"Is the triple ""Folic Acid related to Reduced blood folate concentration"" supported by the sentence: ""Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.""?",False, -7229825,Folic Acid related to iron deficiency anemia,2521,Status of labile folate in iron deficiency anaemia.,"Is the triple ""Folic Acid related to iron deficiency anemia"" supported by the sentence: ""Status of labile folate in iron deficiency anaemia.""?",False, -7175279,Folic Acid related to rheumatoid arthritis,2522,[Methotrexate and folates in rheumatoid arthritis].,"Is the triple ""Folic Acid related to rheumatoid arthritis"" supported by the sentence: ""[Methotrexate and folates in rheumatoid arthritis].""?",False, -25522909,Folic Acid causes diabetic kidney disease,2523,"The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.","Is the triple ""Folic Acid causes diabetic kidney disease"" supported by the sentence: ""The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.""?",False, -18689556,Folic Acid causes Alzheimer disease,2524,Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.,"Is the triple ""Folic Acid causes Alzheimer disease"" supported by the sentence: ""Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.""?",False, -17559847,Folic Acid causes iron deficiency anemia,2525,"With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).","Is the triple ""Folic Acid causes iron deficiency anemia"" supported by the sentence: ""With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).""?",False, -17044072,Folic Acid causes depressive disorder,2526,The low blood level of folates is the primary cause of depression in Alzheimer's disease.,"Is the triple ""Folic Acid causes depressive disorder"" supported by the sentence: ""The low blood level of folates is the primary cause of depression in Alzheimer's disease.""?",False, -15826434,Folic Acid causes male infertility,2527,This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.,"Is the triple ""Folic Acid causes male infertility"" supported by the sentence: ""This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.""?",False, -15057448,Folic Acid causes chronic kidney disease,2528,"The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.","Is the triple ""Folic Acid causes chronic kidney disease"" supported by the sentence: ""The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.""?",False, -14954987,Folic Acid causes autism spectrum disorder,2529,"Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.","Is the triple ""Folic Acid causes autism spectrum disorder"" supported by the sentence: ""Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.""?",False, -13825749,Folic Acid causes cleft lip,2530,The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).,"Is the triple ""Folic Acid causes cleft lip"" supported by the sentence: ""The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).""?",False, -13656973,Folic Acid causes neoplasm,2531,Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.,"Is the triple ""Folic Acid causes neoplasm"" supported by the sentence: ""Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.""?",False, -12212539,Folic Acid causes lymphoma,2532,"Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.","Is the triple ""Folic Acid causes lymphoma"" supported by the sentence: ""Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.""?",False, -11472417,Folic Acid causes gingival overgrowth,2533,Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.,"Is the triple ""Folic Acid causes gingival overgrowth"" supported by the sentence: ""Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.""?",False, -11073752,Folic Acid causes myocardial ischemia,2534,[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].,"Is the triple ""Folic Acid causes myocardial ischemia"" supported by the sentence: ""[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].""?",False, -10016854,Folic Acid causes hypertensive disorder,2535,"In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.","Is the triple ""Folic Acid causes hypertensive disorder"" supported by the sentence: ""In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.""?",False, -8671948,Folic Acid causes cleft palate,2536,"These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.","Is the triple ""Folic Acid causes cleft palate"" supported by the sentence: ""These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.""?",False, -8640403,Folic Acid causes epilepsy,2537,Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.,"Is the triple ""Folic Acid causes epilepsy"" supported by the sentence: ""Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.""?",False, -7900734,Folic Acid causes coronary artery disorder,2538,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes coronary artery disorder"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, -7900729,Folic Acid causes atherosclerosis,2539,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, -7637475,Folic Acid causes Reduced blood folate concentration,2540,"The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.","Is the triple ""Folic Acid causes Reduced blood folate concentration"" supported by the sentence: ""The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.""?",False, -7460069,Folic Acid causes anemia,2541,"If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.","Is the triple ""Folic Acid causes anemia"" supported by the sentence: ""If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.""?",False, -7392389,Folic Acid causes neural tube defect,2542,The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.,"Is the triple ""Folic Acid causes neural tube defect"" supported by the sentence: ""The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.""?",False, -27400709,Folic Acid affects coronary artery disorder,2543,"Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.","Is the triple ""Folic Acid affects coronary artery disorder"" supported by the sentence: ""Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.""?",False, -27350602,Folic Acid affects cleft palate,2544,"Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.""?",False, -26684582,Folic Acid affects colorectal neoplasm,2545,The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.,"Is the triple ""Folic Acid affects colorectal neoplasm"" supported by the sentence: ""The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.""?",False, -26504524,Folic Acid affects neoplasm,2546,"In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.""?",False, -26433324,Folic Acid affects psychotic disorder,2547,Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.,"Is the triple ""Folic Acid affects psychotic disorder"" supported by the sentence: ""Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.""?",False, -25046427,Folic Acid affects malaria,2548,Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.,"Is the triple ""Folic Acid affects malaria"" supported by the sentence: ""Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.""?",False, -24121807,Folic Acid affects osteoporosis,2549,"However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.","Is the triple ""Folic Acid affects osteoporosis"" supported by the sentence: ""However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.""?",False, -23769753,Folic Acid affects anemia,2550,Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.,"Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.""?",False, -22602503,Folic Acid affects gingival overgrowth,2551,The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.,"Is the triple ""Folic Acid affects gingival overgrowth"" supported by the sentence: ""The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.""?",False, -21177262,Folic Acid affects autism spectrum disorder,2552,The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.,"Is the triple ""Folic Acid affects autism spectrum disorder"" supported by the sentence: ""The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.""?",False, -20060781,Folic Acid affects Hemorrhage,2553,"Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.","Is the triple ""Folic Acid affects Hemorrhage"" supported by the sentence: ""Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.""?",False, -19336710,Folic Acid affects polycystic ovary syndrome,2554,"Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).","Is the triple ""Folic Acid affects polycystic ovary syndrome"" supported by the sentence: ""Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).""?",False, -19172236,Folic Acid affects chronic kidney disease,2555,"Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.","Is the triple ""Folic Acid affects chronic kidney disease"" supported by the sentence: ""Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.""?",False, -19066599,Folic Acid affects Alzheimer disease,2556,"Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.""?",False, -15798837,Folic Acid affects hypertensive disorder,2557,"BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.","Is the triple ""Folic Acid affects hypertensive disorder"" supported by the sentence: ""BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.""?",False, -15143772,Folic Acid affects Reduced blood folate concentration,2558,"However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.""?",False, -14869410,Folic Acid affects epilepsy,2559,It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.,"Is the triple ""Folic Acid affects epilepsy"" supported by the sentence: ""It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.""?",False, -14664528,Folic Acid affects depressive disorder,2560,Our findings that poor folate status may increase depression needs to be further investigated.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Our findings that poor folate status may increase depression needs to be further investigated.""?",False, -14002988,Folic Acid affects depressive disorder,2561,We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.""?",False, -13092563,Folic Acid affects depressive disorder,2562,"Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.","Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.""?",False, -12773835,Folic Acid affects atherosclerosis,2563,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""Folic Acid affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, -11897009,Folic Acid affects Alzheimer disease,2564,"As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.""?",False, -10798682,Folic Acid affects type 2 diabetes mellitus,2565,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""Folic Acid affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, -10733114,Folic Acid affects Reduced blood folate concentration,2566,"Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.""?",False, -10375553,Folic Acid affects neoplasm,2567,"When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.""?",False, -10355008,Folic Acid affects anemia,2568,"The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.","Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.""?",False, -8962241,Folic Acid affects cleft palate,2569,"OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.""?",False, -8101952,Folic Acid affects neural tube defect,2570,"CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.""?",False, -7127212,Folic Acid affects neural tube defect,2571,"To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.""?",False, -19290979,Folic Acid produces neoplasm,2572,"Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.","Is the triple ""Folic Acid produces neoplasm"" supported by the sentence: ""Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.""?",False, -26301481,Folic Acid disrupts epilepsy,2573,A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.,"Is the triple ""Folic Acid disrupts epilepsy"" supported by the sentence: ""A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.""?",False, -22602502,Folic Acid disrupts gingival overgrowth,2574,"Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.","Is the triple ""Folic Acid disrupts gingival overgrowth"" supported by the sentence: ""Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.""?",False, -21452213,Folic Acid disrupts cleft palate,2575,"Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).","Is the triple ""Folic Acid disrupts cleft palate"" supported by the sentence: ""Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).""?",False, -20711939,Folic Acid disrupts autism spectrum disorder,2576,Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.,"Is the triple ""Folic Acid disrupts autism spectrum disorder"" supported by the sentence: ""Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.""?",False, -20091947,Folic Acid disrupts atherosclerosis,2577,"Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.","Is the triple ""Folic Acid disrupts atherosclerosis"" supported by the sentence: ""Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.""?",False, -18758283,Folic Acid disrupts malaria,2578,"Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.","Is the triple ""Folic Acid disrupts malaria"" supported by the sentence: ""Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.""?",False, -18711179,Folic Acid disrupts hypertensive disorder,2579,"Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.","Is the triple ""Folic Acid disrupts hypertensive disorder"" supported by the sentence: ""Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.""?",False, -16597425,Folic Acid disrupts neoplasm,2580,"Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.","Is the triple ""Folic Acid disrupts neoplasm"" supported by the sentence: ""Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.""?",False, -13887579,Folic Acid disrupts anemia,2581,Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.,"Is the triple ""Folic Acid disrupts anemia"" supported by the sentence: ""Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.""?",False, -13415357,Folic Acid disrupts cleft lip,2582,[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].,"Is the triple ""Folic Acid disrupts cleft lip"" supported by the sentence: ""[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].""?",False, -12569851,Folic Acid disrupts HIV infectious disease,2583,"Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.","Is the triple ""Folic Acid disrupts HIV infectious disease"" supported by the sentence: ""Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.""?",False, -11807458,Folic Acid disrupts colorectal neoplasm,2584,Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.,"Is the triple ""Folic Acid disrupts colorectal neoplasm"" supported by the sentence: ""Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.""?",False, -10170875,Folic Acid disrupts depressive disorder,2585,The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.,"Is the triple ""Folic Acid disrupts depressive disorder"" supported by the sentence: ""The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.""?",False, -8333532,Folic Acid disrupts neural tube defect,2586,"Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.","Is the triple ""Folic Acid disrupts neural tube defect"" supported by the sentence: ""Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.""?",False, -8088152,Folic Acid disrupts Reduced blood folate concentration,2587,"We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.","Is the triple ""Folic Acid disrupts Reduced blood folate concentration"" supported by the sentence: ""We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.""?",False, -7255352,Folic Acid disrupts coronary artery disorder,2588,Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.,"Is the triple ""Folic Acid disrupts coronary artery disorder"" supported by the sentence: ""Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.""?",False, -24827653,Folic Acid prevents Hemorrhage,2589,"Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.","Is the triple ""Folic Acid prevents Hemorrhage"" supported by the sentence: ""Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.""?",False, -19249670,Folic Acid prevents epilepsy,2590,"The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.","Is the triple ""Folic Acid prevents epilepsy"" supported by the sentence: ""The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.""?",False, -18676969,Folic Acid prevents neoplasm,2591,"Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.","Is the triple ""Folic Acid prevents neoplasm"" supported by the sentence: ""Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.""?",False, -17577921,Folic Acid prevents diabetic kidney disease,2592,Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.,"Is the triple ""Folic Acid prevents diabetic kidney disease"" supported by the sentence: ""Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.""?",False, -16233198,Folic Acid prevents iron deficiency anemia,2593,"UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.","Is the triple ""Folic Acid prevents iron deficiency anemia"" supported by the sentence: ""UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.""?",False, -15458838,Folic Acid prevents myocardial ischemia,2594,"Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.","Is the triple ""Folic Acid prevents myocardial ischemia"" supported by the sentence: ""Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.""?",False, -15385859,Folic Acid prevents depressive disorder,2595,These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.,"Is the triple ""Folic Acid prevents depressive disorder"" supported by the sentence: ""These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.""?",False, -13602735,Folic Acid prevents gingival overgrowth,2596,A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.,"Is the triple ""Folic Acid prevents gingival overgrowth"" supported by the sentence: ""A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.""?",False, -12999215,Folic Acid prevents hypertensive disorder,2597,"Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.","Is the triple ""Folic Acid prevents hypertensive disorder"" supported by the sentence: ""Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.""?",False, -12947495,Folic Acid prevents cleft lip,2598,CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.,"Is the triple ""Folic Acid prevents cleft lip"" supported by the sentence: ""CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.""?",False, -12911127,Folic Acid prevents Alzheimer disease,2599,BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.,"Is the triple ""Folic Acid prevents Alzheimer disease"" supported by the sentence: ""BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.""?",False, -11842763,Folic Acid prevents cervical polyp,2600,"Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.","Is the triple ""Folic Acid prevents cervical polyp"" supported by the sentence: ""Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.""?",False, -10283354,Folic Acid prevents heart disorder,2601,"Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?","Is the triple ""Folic Acid prevents heart disorder"" supported by the sentence: ""Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?""?",False, -10242010,Folic Acid prevents cleft palate,2602,"CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.","Is the triple ""Folic Acid prevents cleft palate"" supported by the sentence: ""CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.""?",False, -9547944,Folic Acid prevents atherosclerosis,2603,CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.,"Is the triple ""Folic Acid prevents atherosclerosis"" supported by the sentence: ""CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.""?",False, -9000016,Folic Acid prevents anemia,2604,OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.,"Is the triple ""Folic Acid prevents anemia"" supported by the sentence: ""OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.""?",False, -8746975,Folic Acid prevents Reduced blood folate concentration,2605,The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.,"Is the triple ""Folic Acid prevents Reduced blood folate concentration"" supported by the sentence: ""The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.""?",False, -8675157,Folic Acid prevents coronary artery disorder,2606,"Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.","Is the triple ""Folic Acid prevents coronary artery disorder"" supported by the sentence: ""Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.""?",False, -8467407,Folic Acid prevents myocardial infarction,2607,"Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.","Is the triple ""Folic Acid prevents myocardial infarction"" supported by the sentence: ""Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.""?",False, -7303516,Folic Acid prevents neural tube defect,2608,She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.,"Is the triple ""Folic Acid prevents neural tube defect"" supported by the sentence: ""She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.""?",False, -23795062,Folic Acid predisposes depressive disorder,2609,A low level of folate is also thought to be a risk for depression in adults.,"Is the triple ""Folic Acid predisposes depressive disorder"" supported by the sentence: ""A low level of folate is also thought to be a risk for depression in adults.""?",False, -20875914,Folic Acid predisposes chronic kidney disease,2610,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""Folic Acid predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, -20436878,Folic Acid predisposes psychotic disorder,2611,"Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.","Is the triple ""Folic Acid predisposes psychotic disorder"" supported by the sentence: ""Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.""?",False, -19071958,Folic Acid predisposes type 1 diabetes mellitus,2612,"The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.","Is the triple ""Folic Acid predisposes type 1 diabetes mellitus"" supported by the sentence: ""The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.""?",False, -18723777,Folic Acid predisposes systemic lupus erythematosus,2613,"CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.","Is the triple ""Folic Acid predisposes systemic lupus erythematosus"" supported by the sentence: ""CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.""?",False, -16571781,Folic Acid predisposes habitual spontaneous abortion,2614,"Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.","Is the triple ""Folic Acid predisposes habitual spontaneous abortion"" supported by the sentence: ""Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.""?",False, -16186991,Folic Acid predisposes Reduced blood folate concentration,2615,"This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.","Is the triple ""Folic Acid predisposes Reduced blood folate concentration"" supported by the sentence: ""This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.""?",False, -15780148,Folic Acid predisposes epilepsy,2616,Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.,"Is the triple ""Folic Acid predisposes epilepsy"" supported by the sentence: ""Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.""?",False, -15351663,Folic Acid predisposes breast neoplasm,2617,Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.,"Is the triple ""Folic Acid predisposes breast neoplasm"" supported by the sentence: ""Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.""?",False, -14681570,Folic Acid predisposes malaria,2618,"Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.","Is the triple ""Folic Acid predisposes malaria"" supported by the sentence: ""Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.""?",False, -13204073,Folic Acid predisposes autism spectrum disorder,2619,"Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.","Is the triple ""Folic Acid predisposes autism spectrum disorder"" supported by the sentence: ""Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.""?",False, -12966788,Folic Acid predisposes cleft palate,2620,"In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.","Is the triple ""Folic Acid predisposes cleft palate"" supported by the sentence: ""In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.""?",False, -12851634,Folic Acid predisposes osteoporosis,2621,"We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.","Is the triple ""Folic Acid predisposes osteoporosis"" supported by the sentence: ""We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.""?",False, -12628867,Folic Acid predisposes neoplasm,2622,"In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.","Is the triple ""Folic Acid predisposes neoplasm"" supported by the sentence: ""In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.""?",False, -11373442,Folic Acid predisposes colorectal neoplasm,2623,Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.,"Is the triple ""Folic Acid predisposes colorectal neoplasm"" supported by the sentence: ""Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.""?",False, -11241979,Folic Acid predisposes hypertensive disorder,2624,"CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.","Is the triple ""Folic Acid predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.""?",False, -9419598,Folic Acid predisposes Alzheimer disease,2625,"Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.","Is the triple ""Folic Acid predisposes Alzheimer disease"" supported by the sentence: ""Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.""?",False, -9024956,Folic Acid predisposes non-small cell lung carcinoma,2626,CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.,"Is the triple ""Folic Acid predisposes non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.""?",False, -8876702,Folic Acid predisposes atherosclerosis,2627,"The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.","Is the triple ""Folic Acid predisposes atherosclerosis"" supported by the sentence: ""The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.""?",False, -8590186,Folic Acid predisposes anemia,2628,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""Folic Acid predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, -8210149,Folic Acid predisposes myocardial ischemia,2629,Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.,"Is the triple ""Folic Acid predisposes myocardial ischemia"" supported by the sentence: ""Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.""?",False, -8202566,Folic Acid predisposes coronary artery disorder,2630,"Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.","Is the triple ""Folic Acid predisposes coronary artery disorder"" supported by the sentence: ""Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.""?",False, -7807562,Folic Acid predisposes myocardial infarction,2631,The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.,"Is the triple ""Folic Acid predisposes myocardial infarction"" supported by the sentence: ""The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.""?",False, -7720012,Phenylbutazone subclass of Oxyphenbutazone,2632,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Phenylbutazone subclass of Oxyphenbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, -26246718,Phenylbutazone related to Oxyphenbutazone,2633,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, -25613560,Phenylbutazone related to Oxyphenbutazone,2634,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, -20340997,Phenylbutazone physically interacts with Oxyphenbutazone,2635,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Phenylbutazone physically interacts with Oxyphenbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, -26417219,"Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",2636,"At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.","Is the triple ""Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine"" supported by the sentence: ""At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.""?",False, -17467114,Phenylbutazone affects rheumatic disorder,2637,[Research on the mechanism of action of phenylbutazone in rheumatic diseases].,"Is the triple ""Phenylbutazone affects rheumatic disorder"" supported by the sentence: ""[Research on the mechanism of action of phenylbutazone in rheumatic diseases].""?",False, -8146434,Phenylbutazone affects Oxyphenbutazone,2638,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Phenylbutazone affects Oxyphenbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, -7720012,Oxyphenbutazone subclass of Phenylbutazone,2639,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Oxyphenbutazone subclass of Phenylbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, -25613560,Oxyphenbutazone related to Phenylbutazone,2640,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, -26246718,Oxyphenbutazone related to Phenylbutazone,2641,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, -20340997,Oxyphenbutazone physically interacts with Phenylbutazone,2642,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Oxyphenbutazone physically interacts with Phenylbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, -8146434,Oxyphenbutazone affects Phenylbutazone,2643,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Oxyphenbutazone affects Phenylbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, -19336632,Etofenamate prevents Arthralgia,2644,The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.,"Is the triple ""Etofenamate prevents Arthralgia"" supported by the sentence: ""The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.""?",False, -11418550,Piroxicam subclass of 5'-Hydroxypiroxicam,2645,"The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.","Is the triple ""Piroxicam subclass of 5'-Hydroxypiroxicam"" supported by the sentence: ""The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.""?",False, -27695181,Piroxicam affects osteoarthritis,2646,Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.,"Is the triple ""Piroxicam affects osteoarthritis"" supported by the sentence: ""Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.""?",False, -24435495,Piroxicam affects Pain,2647,The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.,"Is the triple ""Piroxicam affects Pain"" supported by the sentence: ""The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.""?",False, -18791248,Piroxicam disrupts Pain,2648,Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.,"Is the triple ""Piroxicam disrupts Pain"" supported by the sentence: ""Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.""?",False, -13746683,Piroxicam prevents Myalgia,2649,"We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.","Is the triple ""Piroxicam prevents Myalgia"" supported by the sentence: ""We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.""?",False, -13092622,Piroxicam prevents Pain,2650,"CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.","Is the triple ""Piroxicam prevents Pain"" supported by the sentence: ""CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.""?",False, -9050885,Bufexamac related to rheumatic disorder,2651,[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].,"Is the triple ""Bufexamac related to rheumatic disorder"" supported by the sentence: ""[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].""?",False, -27600921,Mometasone furoate related to psoriasis,2652,[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].,"Is the triple ""Mometasone furoate related to psoriasis"" supported by the sentence: ""[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].""?",False, -26936147,Mometasone furoate related to skin disorder,2653,Mometasone versus betamethasone creams: a trial in dermatoses.,"Is the triple ""Mometasone furoate related to skin disorder"" supported by the sentence: ""Mometasone versus betamethasone creams: a trial in dermatoses.""?",False, -20328277,Mometasone furoate related to obstructive sleep apnea syndrome,2654,"Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.","Is the triple ""Mometasone furoate related to obstructive sleep apnea syndrome"" supported by the sentence: ""Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.""?",False, -20031657,Mometasone furoate related to diffuse alopecia areata,2655,Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.,"Is the triple ""Mometasone furoate related to diffuse alopecia areata"" supported by the sentence: ""Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.""?",False, -18451558,Mometasone furoate related to spinal cord injury,2656,The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).,"Is the triple ""Mometasone furoate related to spinal cord injury"" supported by the sentence: ""The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).""?",False, -15193244,Mometasone furoate related to severe acute respiratory syndrome,2657,CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.,"Is the triple ""Mometasone furoate related to severe acute respiratory syndrome"" supported by the sentence: ""CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.""?",False, -12129006,Mometasone furoate related to asthma,2658,Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.,"Is the triple ""Mometasone furoate related to asthma"" supported by the sentence: ""Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.""?",False, -12122099,Mometasone furoate related to allergic rhinitis,2659,"The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.","Is the triple ""Mometasone furoate related to allergic rhinitis"" supported by the sentence: ""The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.""?",False, -11696210,Mometasone furoate related to chronic obstructive pulmonary disease,2660,Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.,"Is the triple ""Mometasone furoate related to chronic obstructive pulmonary disease"" supported by the sentence: ""Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.""?",False, -10078337,Mometasone furoate related to perennial allergic rhinitis,2661,Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.,"Is the triple ""Mometasone furoate related to perennial allergic rhinitis"" supported by the sentence: ""Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.""?",False, -8366912,Mometasone furoate related to seasonal allergic rhinitis,2662,[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].,"Is the triple ""Mometasone furoate related to seasonal allergic rhinitis"" supported by the sentence: ""[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].""?",False, -15620377,Mometasone furoate affects asthma,2663,"Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).","Is the triple ""Mometasone furoate affects asthma"" supported by the sentence: ""Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).""?",False, -14474022,Mometasone furoate affects Nasal congestion,2664,CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.,"Is the triple ""Mometasone furoate affects Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.""?",False, -8375063,Mometasone furoate affects allergic rhinitis,2665,The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.,"Is the triple ""Mometasone furoate affects allergic rhinitis"" supported by the sentence: ""The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.""?",False, -17026384,Mometasone furoate prevents Nasal congestion,2666,CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.,"Is the triple ""Mometasone furoate prevents Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.""?",False, -15945486,Mometasone furoate prevents nasal cavity polyp,2667,Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.,"Is the triple ""Mometasone furoate prevents nasal cavity polyp"" supported by the sentence: ""Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.""?",False, -10581126,Methimazole related to hyperthyroidism,2668,Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.,"Is the triple ""Methimazole related to hyperthyroidism"" supported by the sentence: ""Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.""?",False, -8213703,Methimazole causes hyperthyroidism,2669,"These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.","Is the triple ""Methimazole causes hyperthyroidism"" supported by the sentence: ""These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.""?",False, -10543639,Methimazole affects hyperthyroidism,2670,Exacerbation of hyperthyroidism by methimazole during iodide therapy.,"Is the triple ""Methimazole affects hyperthyroidism"" supported by the sentence: ""Exacerbation of hyperthyroidism by methimazole during iodide therapy.""?",False, -25010771,Methimazole prevents hyperthyroidism,2671,"Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.","Is the triple ""Methimazole prevents hyperthyroidism"" supported by the sentence: ""Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.""?",False, -24946616,Safinamide physically interacts with Monoamine Oxidase B,2672,"Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.","Is the triple ""Safinamide physically interacts with Monoamine Oxidase B"" supported by the sentence: ""Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.""?",False, -19231919,Safinamide affects Parkinson disease,2673,"The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.","Is the triple ""Safinamide affects Parkinson disease"" supported by the sentence: ""The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.""?",False, -13464423,Safinamide affects Monoamine Oxidase B,2674,"A third agent with MAO-B inhibition properties, safinamide, is in phase III development.","Is the triple ""Safinamide affects Monoamine Oxidase B"" supported by the sentence: ""A third agent with MAO-B inhibition properties, safinamide, is in phase III development.""?",False, -25942595,Furosemide related to nephrotic syndrome,2675,[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].,"Is the triple ""Furosemide related to nephrotic syndrome"" supported by the sentence: ""[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].""?",False, -25824332,Furosemide related to Fibrosis,2676,Spironolactone and frusemide in cirrhosis with ascites.,"Is the triple ""Furosemide related to Fibrosis"" supported by the sentence: ""Spironolactone and frusemide in cirrhosis with ascites.""?",False, -25791999,Furosemide related to cirrhosis of liver,2677,[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].,"Is the triple ""Furosemide related to cirrhosis of liver"" supported by the sentence: ""[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].""?",False, -25414865,Furosemide related to syndromic disease,2678,"In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.","Is the triple ""Furosemide related to syndromic disease"" supported by the sentence: ""In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.""?",False, -24461287,Furosemide related to essential hypertension,2679,Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.,"Is the triple ""Furosemide related to essential hypertension"" supported by the sentence: ""Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.""?",False, -22834232,Furosemide related to type 2 diabetes mellitus,2680,The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.,"Is the triple ""Furosemide related to type 2 diabetes mellitus"" supported by the sentence: ""The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.""?",False, -19148228,Furosemide related to hypertensive disorder,2681,"A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.","Is the triple ""Furosemide related to hypertensive disorder"" supported by the sentence: ""A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.""?",False, -13031496,Furosemide related to acute kidney failure,2682,Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.,"Is the triple ""Furosemide related to acute kidney failure"" supported by the sentence: ""Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.""?",False, -8084093,Furosemide related to kidney failure,2683,"The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.","Is the triple ""Furosemide related to kidney failure"" supported by the sentence: ""The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.""?",False, -27482853,Furosemide causes Edema,2684,In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.,"Is the triple ""Furosemide causes Edema"" supported by the sentence: ""In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.""?",False, -27015887,Furosemide causes diabetes mellitus,2685,Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.,"Is the triple ""Furosemide causes diabetes mellitus"" supported by the sentence: ""Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.""?",False, -25990601,Furosemide causes hypertensive disorder,2686,[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].,"Is the triple ""Furosemide causes hypertensive disorder"" supported by the sentence: ""[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].""?",False, -25918508,Furosemide causes kidney disorder,2687,[Furosemide-induced nephropathy (author's transl)].,"Is the triple ""Furosemide causes kidney disorder"" supported by the sentence: ""[Furosemide-induced nephropathy (author's transl)].""?",False, -20167150,Furosemide causes syndromic disease,2688,"CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.","Is the triple ""Furosemide causes syndromic disease"" supported by the sentence: ""CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.""?",False, -19659078,Furosemide causes kidney failure,2689,"Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).","Is the triple ""Furosemide causes kidney failure"" supported by the sentence: ""Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).""?",False, -11605290,Furosemide causes nephrotic syndrome,2690,"Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.","Is the triple ""Furosemide causes nephrotic syndrome"" supported by the sentence: ""Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.""?",False, -9601857,Furosemide causes acute kidney failure,2691,"Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.","Is the triple ""Furosemide causes acute kidney failure"" supported by the sentence: ""Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.""?",False, -8252635,Furosemide causes Dyspnea,2692,Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.,"Is the triple ""Furosemide causes Dyspnea"" supported by the sentence: ""Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.""?",False, -26185017,Furosemide affects myocardial infarction,2693,Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.,"Is the triple ""Furosemide affects myocardial infarction"" supported by the sentence: ""Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.""?",False, -25909260,Furosemide affects nephrotic syndrome,2694,Plasma volume and effect of high dose frusemide in nephrotic syndrome.,"Is the triple ""Furosemide affects nephrotic syndrome"" supported by the sentence: ""Plasma volume and effect of high dose frusemide in nephrotic syndrome.""?",False, -22504977,Furosemide affects cirrhosis of liver,2695,"Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.","Is the triple ""Furosemide affects cirrhosis of liver"" supported by the sentence: ""Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.""?",False, -17729926,Furosemide affects Edema,2696,"Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.""?",False, -16155102,Furosemide affects kidney disorder,2697,"This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.","Is the triple ""Furosemide affects kidney disorder"" supported by the sentence: ""This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.""?",False, -15732141,Furosemide affects hypertensive disorder,2698,As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.,"Is the triple ""Furosemide affects hypertensive disorder"" supported by the sentence: ""As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.""?",False, -14935630,Furosemide affects kidney failure,2699,"In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.","Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.""?",False, -14887041,Furosemide affects acute kidney failure,2700,CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.""?",False, -14148250,Furosemide affects kidney failure,2701,OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.,"Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.""?",False, -13740455,Furosemide affects Dyspnea,2702,"Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.","Is the triple ""Furosemide affects Dyspnea"" supported by the sentence: ""Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.""?",False, -12836864,Furosemide affects Edema,2703,"BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.""?",False, -10718312,Furosemide affects diabetes mellitus,2704,[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].,"Is the triple ""Furosemide affects diabetes mellitus"" supported by the sentence: ""[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].""?",False, -8299615,Furosemide affects acute kidney failure,2705,Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.""?",False, -27482854,Furosemide disrupts Edema,2706,Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.,"Is the triple ""Furosemide disrupts Edema"" supported by the sentence: ""Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.""?",False, -19844878,Furosemide disrupts Dyspnea,2707,"At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.","Is the triple ""Furosemide disrupts Dyspnea"" supported by the sentence: ""At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.""?",False, -24717003,Furosemide prevents pulmonary edema,2708,"Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.","Is the triple ""Furosemide prevents pulmonary edema"" supported by the sentence: ""Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.""?",False, -22953098,Furosemide prevents Dyspnea,2709,"Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.","Is the triple ""Furosemide prevents Dyspnea"" supported by the sentence: ""Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.""?",False, -21527038,Furosemide prevents schizophrenia,2710,"Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.","Is the triple ""Furosemide prevents schizophrenia"" supported by the sentence: ""Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.""?",False, -20769925,Furosemide prevents bronchopulmonary dysplasia,2711,CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.,"Is the triple ""Furosemide prevents bronchopulmonary dysplasia"" supported by the sentence: ""CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.""?",False, -12415888,Furosemide prevents kidney disorder,2712,The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.,"Is the triple ""Furosemide prevents kidney disorder"" supported by the sentence: ""The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.""?",False, -11075685,Furosemide prevents hypertensive disorder,2713,"The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.","Is the triple ""Furosemide prevents hypertensive disorder"" supported by the sentence: ""The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.""?",False, -9165205,Furosemide prevents Edema,2714,Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.,"Is the triple ""Furosemide prevents Edema"" supported by the sentence: ""Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.""?",False, -8733555,Furosemide prevents syndromic disease,2715,"The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".","Is the triple ""Furosemide prevents syndromic disease"" supported by the sentence: ""The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".""?",False, -7901682,Furosemide prevents kidney failure,2716,"In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.","Is the triple ""Furosemide prevents kidney failure"" supported by the sentence: ""In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.""?",False, -24388792,Furosemide predisposes acute kidney failure,2717,Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?,"Is the triple ""Furosemide predisposes acute kidney failure"" supported by the sentence: ""Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?""?",False, -23800241,Furosemide predisposes myocardial infarction,2718,"METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).","Is the triple ""Furosemide predisposes myocardial infarction"" supported by the sentence: ""METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).""?",False, -21525697,Furosemide predisposes atherosclerosis,2719,"RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).","Is the triple ""Furosemide predisposes atherosclerosis"" supported by the sentence: ""RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).""?",False, -16660855,Furosemide predisposes kidney disorder,2720,"Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).","Is the triple ""Furosemide predisposes kidney disorder"" supported by the sentence: ""Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).""?",False, -19565633,Nabumetone physically interacts with Cyclooxygenase 2,2721,"The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.""?",False, -14176438,Nabumetone physically interacts with Cyclooxygenase 2,2722,"Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.""?",False, -15189827,Nabumetone affects osteoarthritis,2723,Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.,"Is the triple ""Nabumetone affects osteoarthritis"" supported by the sentence: ""Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.""?",False, -9219116,Nabumetone affects Cyclooxygenase 2,2724,"Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.","Is the triple ""Nabumetone affects Cyclooxygenase 2"" supported by the sentence: ""Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.""?",False, -11784119,Selegiline related to Parkinson disease,2725,Long-term experience with selegiline and levodopa in Parkinson's disease.,"Is the triple ""Selegiline related to Parkinson disease"" supported by the sentence: ""Long-term experience with selegiline and levodopa in Parkinson's disease.""?",False, -7091710,Selegiline related to Monoamine Oxidase B,2726,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, -7091710,Selegiline related to Monoamine Oxidase B,2727,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, -26670675,Selegiline coexists with Monoamine Oxidase B,2728,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, -26670675,Selegiline coexists with Monoamine Oxidase B,2729,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, -13016594,Selegiline physically interacts with Monoamine Oxidase B,2730,L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.,"Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.""?",False, -26762387,Selegiline physically interacts with Monoamine Oxidase B,2731,"MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.","Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.""?",False, -27251718,Selegiline causes depressive disorder,2732,These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.,"Is the triple ""Selegiline causes depressive disorder"" supported by the sentence: ""These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.""?",False, -18216942,Selegiline causes Parkinson disease,2733,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Selegiline causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, -8842901,Selegiline affects Parkinson disease,2734,Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.,"Is the triple ""Selegiline affects Parkinson disease"" supported by the sentence: ""Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.""?",False, -7091708,Selegiline affects Monoamine Oxidase B,2735,"In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.","Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.""?",False, -8615177,Selegiline affects Monoamine Oxidase B,2736,MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.,"Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.""?",False, -11022843,Selegiline disrupts Parkinson disease,2737,"Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.","Is the triple ""Selegiline disrupts Parkinson disease"" supported by the sentence: ""Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.""?",False, -8202759,Selegiline prevents depressive disorder,2738,"The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.","Is the triple ""Selegiline prevents depressive disorder"" supported by the sentence: ""The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.""?",False, -7205408,Selegiline prevents Parkinson disease,2739,Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.,"Is the triple ""Selegiline prevents Parkinson disease"" supported by the sentence: ""Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.""?",False, -21543223,Bumetanide causes pervasive developmental disorder,2740,This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.,"Is the triple ""Bumetanide causes pervasive developmental disorder"" supported by the sentence: ""This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.""?",False, -22325231,Bumetanide affects pervasive developmental disorder,2741,"Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).","Is the triple ""Bumetanide affects pervasive developmental disorder"" supported by the sentence: ""Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).""?",False, -20190253,Bumetanide affects autism spectrum disorder,2742,Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.,"Is the triple ""Bumetanide affects autism spectrum disorder"" supported by the sentence: ""Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.""?",False, -16914848,Bumetanide prevents autism spectrum disorder,2743,"UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.","Is the triple ""Bumetanide prevents autism spectrum disorder"" supported by the sentence: ""UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.""?",False, -11943751,D-Glucosamine related to breast neoplasm,2744,Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.,"Is the triple ""D-Glucosamine related to breast neoplasm"" supported by the sentence: ""Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.""?",False, -7809202,D-Glucosamine related to osteoarthritis,2745,Glucosamine in osteoarthritis.,"Is the triple ""D-Glucosamine related to osteoarthritis"" supported by the sentence: ""Glucosamine in osteoarthritis.""?",False, -27619077,D-Glucosamine causes obesity disorder,2746,"Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.","Is the triple ""D-Glucosamine causes obesity disorder"" supported by the sentence: ""Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.""?",False, -18633463,D-Glucosamine causes osteoarthritis,2747,Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.,"Is the triple ""D-Glucosamine causes osteoarthritis"" supported by the sentence: ""Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.""?",False, -9909825,D-Glucosamine affects osteoarthritis,2748,The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.,"Is the triple ""D-Glucosamine affects osteoarthritis"" supported by the sentence: ""The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.""?",False, -8968754,D-Glucosamine affects obesity disorder,2749,Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).,"Is the triple ""D-Glucosamine affects obesity disorder"" supported by the sentence: ""Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).""?",False, -13460623,D-Glucosamine disrupts osteoarthritis,2750,"Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.","Is the triple ""D-Glucosamine disrupts osteoarthritis"" supported by the sentence: ""Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.""?",False, -11817662,D-Glucosamine prevents osteoarthritis,2751,"OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.","Is the triple ""D-Glucosamine prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.""?",False, -25749858,Torsemide causes hypertensive disorder,2752,Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.,"Is the triple ""Torsemide causes hypertensive disorder"" supported by the sentence: ""Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.""?",False, -26478746,Torsemide affects hypertensive disorder,2753,"The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.","Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.""?",False, -13754465,Torsemide affects hypertensive disorder,2754,Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.,"Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.""?",False, -24478260,Leuprorelin related to infertility disorder,2755,Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.,"Is the triple ""Leuprorelin related to infertility disorder"" supported by the sentence: ""Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.""?",False, -22375547,Leuprorelin related to neoplasm,2756,"For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.","Is the triple ""Leuprorelin related to neoplasm"" supported by the sentence: ""For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.""?",False, -17696905,Leuprorelin related to leiomyoma,2757,"Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.","Is the triple ""Leuprorelin related to leiomyoma"" supported by the sentence: ""Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.""?",False, -16368292,Leuprorelin related to prostate cancer,2758,OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.,"Is the triple ""Leuprorelin related to prostate cancer"" supported by the sentence: ""OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.""?",False, -15413679,Leuprorelin related to endometriosis,2759,The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.,"Is the triple ""Leuprorelin related to endometriosis"" supported by the sentence: ""The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.""?",False, -9878755,Leuprorelin causes hypogonadism,2760,"Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.","Is the triple ""Leuprorelin causes hypogonadism"" supported by the sentence: ""Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.""?",False, -7418968,Leuprorelin causes neoplasm,2761,"In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.","Is the triple ""Leuprorelin causes neoplasm"" supported by the sentence: ""In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.""?",False, -27571709,Leuprorelin affects prostate cancer,2762,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, -27571708,Leuprorelin affects endometriosis,2763,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, -26547561,Leuprorelin affects endometriosis,2764,"Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.""?",False, -26152029,Leuprorelin affects prostate cancer,2765,Endocrine and clinical effects of leuprolide in prostatic cancer.,"Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""Endocrine and clinical effects of leuprolide in prostatic cancer.""?",False, -27542556,Leuprorelin prevents neoplasm,2766,In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.,"Is the triple ""Leuprorelin prevents neoplasm"" supported by the sentence: ""In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.""?",False, -12402472,Leuprorelin prevents Pain,2767,"CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.","Is the triple ""Leuprorelin prevents Pain"" supported by the sentence: ""CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.""?",False, -7814590,Sodium Bicarbonate subclass of Electrolytes,2768,"Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.","Is the triple ""Sodium Bicarbonate subclass of Electrolytes"" supported by the sentence: ""Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.""?",False, -26447678,Sodium Bicarbonate related to cystic fibrosis,2769,Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.,"Is the triple ""Sodium Bicarbonate related to cystic fibrosis"" supported by the sentence: ""Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.""?",False, -26270339,Sodium Bicarbonate related to kidney failure,2770,"Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.","Is the triple ""Sodium Bicarbonate related to kidney failure"" supported by the sentence: ""Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.""?",False, -20718850,Sodium Bicarbonate related to acidosis disorder,2771,There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.,"Is the triple ""Sodium Bicarbonate related to acidosis disorder"" supported by the sentence: ""There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.""?",False, -15047625,Sodium Bicarbonate related to Pain,2772,"We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.","Is the triple ""Sodium Bicarbonate related to Pain"" supported by the sentence: ""We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.""?",False, -14688492,Sodium Bicarbonate related to chronic renal failure syndrome,2773,"We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.","Is the triple ""Sodium Bicarbonate related to chronic renal failure syndrome"" supported by the sentence: ""We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.""?",False, -13166244,Sodium Bicarbonate related to kidney disorder,2774,REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.,"Is the triple ""Sodium Bicarbonate related to kidney disorder"" supported by the sentence: ""REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.""?",False, -12100581,Sodium Bicarbonate physically interacts with Electrolytes,2775,"NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.""?",False, -13772853,Sodium Bicarbonate physically interacts with Electrolytes,2776,"Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.""?",False, -27495118,Sodium Bicarbonate causes kidney failure,2777,"In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.","Is the triple ""Sodium Bicarbonate causes kidney failure"" supported by the sentence: ""In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.""?",False, -18327883,Sodium Bicarbonate causes kidney disorder,2778,This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.,"Is the triple ""Sodium Bicarbonate causes kidney disorder"" supported by the sentence: ""This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.""?",False, -14549296,Sodium Bicarbonate causes injury,2779,Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.,"Is the triple ""Sodium Bicarbonate causes injury"" supported by the sentence: ""Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.""?",False, -8914995,Sodium Bicarbonate causes acidosis disorder,2780,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate causes acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, -25712033,Sodium Bicarbonate affects Abnormality of acid-base homeostasis,2781,An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.,"Is the triple ""Sodium Bicarbonate affects Abnormality of acid-base homeostasis"" supported by the sentence: ""An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.""?",False, -18411502,Sodium Bicarbonate affects injury,2782,OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.,"Is the triple ""Sodium Bicarbonate affects injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.""?",False, -17654743,Sodium Bicarbonate affects kidney disorder,2783,"Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.","Is the triple ""Sodium Bicarbonate affects kidney disorder"" supported by the sentence: ""Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.""?",False, -12960490,Sodium Bicarbonate affects Pain,2784,Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.,"Is the triple ""Sodium Bicarbonate affects Pain"" supported by the sentence: ""Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.""?",False, -8914994,Sodium Bicarbonate affects acidosis disorder,2785,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate affects acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, -14651482,Sodium Bicarbonate disrupts acidosis disorder,2786,"The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.","Is the triple ""Sodium Bicarbonate disrupts acidosis disorder"" supported by the sentence: ""The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.""?",False, -21103228,Sodium Bicarbonate prevents acidosis disorder,2787,According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.,"Is the triple ""Sodium Bicarbonate prevents acidosis disorder"" supported by the sentence: ""According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.""?",False, -13938650,Sodium Bicarbonate prevents injury,2788,Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.,"Is the triple ""Sodium Bicarbonate prevents injury"" supported by the sentence: ""Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.""?",False, -11746267,Sodium Bicarbonate prevents kidney failure,2789,"SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.","Is the triple ""Sodium Bicarbonate prevents kidney failure"" supported by the sentence: ""SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.""?",False, -11205688,Sodium Bicarbonate prevents acute kidney failure,2790,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Bicarbonate prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, -11205686,Sodium Bicarbonate prevents kidney disorder,2791,Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.,"Is the triple ""Sodium Bicarbonate prevents kidney disorder"" supported by the sentence: ""Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.""?",False, -14663272,Sodium Bicarbonate predisposes kidney disorder,2792,PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.,"Is the triple ""Sodium Bicarbonate predisposes kidney disorder"" supported by the sentence: ""PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.""?",False, -14542214,Sodium Bicarbonate predisposes injury,2793,"We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.","Is the triple ""Sodium Bicarbonate predisposes injury"" supported by the sentence: ""We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.""?",False, -17530350,Olmesartan medoxomil affects diabetic kidney disease,2794,Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.,"Is the triple ""Olmesartan medoxomil affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.""?",False, -12894557,Olmesartan medoxomil affects atherosclerosis,2795,Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.,"Is the triple ""Olmesartan medoxomil affects atherosclerosis"" supported by the sentence: ""Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.""?",False, -12254737,Olmesartan medoxomil affects diabetes mellitus,2796,A further evaluation of the effects of OM in diabetes is warranted.,"Is the triple ""Olmesartan medoxomil affects diabetes mellitus"" supported by the sentence: ""A further evaluation of the effects of OM in diabetes is warranted.""?",False, -15583038,Olmesartan medoxomil disrupts hypertensive disorder,2797,"Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.","Is the triple ""Olmesartan medoxomil disrupts hypertensive disorder"" supported by the sentence: ""Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.""?",False, -12254736,Olmesartan medoxomil disrupts proteinuria,2798,"These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).","Is the triple ""Olmesartan medoxomil disrupts proteinuria"" supported by the sentence: ""These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).""?",False, -12254735,Olmesartan medoxomil prevents hypertensive disorder,2799,"At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.","Is the triple ""Olmesartan medoxomil prevents hypertensive disorder"" supported by the sentence: ""At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.""?",False, -9359700,Olmesartan medoxomil prevents atherosclerosis,2800,This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.,"Is the triple ""Olmesartan medoxomil prevents atherosclerosis"" supported by the sentence: ""This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.""?",False, -8752749,Candesartan related to essential hypertension,2801,Comparison of candesartan versus enalapril in essential hypertension.,"Is the triple ""Candesartan related to essential hypertension"" supported by the sentence: ""Comparison of candesartan versus enalapril in essential hypertension.""?",False, -20752265,Candesartan causes Cognitive impairment,2802,"Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.","Is the triple ""Candesartan causes Cognitive impairment"" supported by the sentence: ""Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.""?",False, -14838058,Candesartan causes hypertensive disorder,2803,"Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.","Is the triple ""Candesartan causes hypertensive disorder"" supported by the sentence: ""Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.""?",False, -20512666,Candesartan affects Cognitive impairment,2804,"We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.""?",False, -20051167,Candesartan affects hypertensive disorder,2805,"Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.""?",False, -19501045,Candesartan affects Cognitive impairment,2806,"METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.""?",False, -14118850,Candesartan affects Left ventricular hypertrophy,2807,"The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.","Is the triple ""Candesartan affects Left ventricular hypertrophy"" supported by the sentence: ""The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.""?",False, -9919312,Candesartan affects hypertensive disorder,2808,"RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).""?",False, -14542524,Candesartan disrupts Left ventricular hypertrophy,2809,"A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.","Is the triple ""Candesartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.""?",False, -9479295,Candesartan disrupts hypertensive disorder,2810,Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.,"Is the triple ""Candesartan disrupts hypertensive disorder"" supported by the sentence: ""Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.""?",False, -24756017,Candesartan prevents Cognitive impairment,2811,"Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.","Is the triple ""Candesartan prevents Cognitive impairment"" supported by the sentence: ""Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.""?",False, -15502429,Candesartan prevents cardiovascular disorder,2812,"The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).","Is the triple ""Candesartan prevents cardiovascular disorder"" supported by the sentence: ""The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).""?",False, -12994289,Candesartan prevents Left ventricular hypertrophy,2813,"Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.","Is the triple ""Candesartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.""?",False, -12444324,Candesartan prevents atrial fibrillation,2814,"CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.","Is the triple ""Candesartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.""?",False, -12421723,Candesartan prevents migraine disorder,2815,"CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.","Is the triple ""Candesartan prevents migraine disorder"" supported by the sentence: ""CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.""?",False, -8787605,Candesartan prevents hypertensive disorder,2816,"When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.","Is the triple ""Candesartan prevents hypertensive disorder"" supported by the sentence: ""When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.""?",False, -9420113,Telmisartan related to diabetes mellitus,2817,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to diabetes mellitus"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, -9420112,Telmisartan related to hypertensive disorder,2818,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to hypertensive disorder"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, -16669618,Telmisartan causes cardiovascular disorder,2819,These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.,"Is the triple ""Telmisartan causes cardiovascular disorder"" supported by the sentence: ""These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.""?",False, -16637024,Telmisartan causes hypertensive disorder,2820,Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.,"Is the triple ""Telmisartan causes hypertensive disorder"" supported by the sentence: ""Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.""?",False, -16559226,Telmisartan causes myocardial infarction,2821,"Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.","Is the triple ""Telmisartan causes myocardial infarction"" supported by the sentence: ""Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.""?",False, -14418892,Telmisartan causes Albuminuria,2822,CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.,"Is the triple ""Telmisartan causes Albuminuria"" supported by the sentence: ""CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.""?",False, -13301662,Telmisartan causes diabetes mellitus,2823,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Telmisartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, -20835589,Telmisartan affects diabetic kidney disease,2824,This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.,"Is the triple ""Telmisartan affects diabetic kidney disease"" supported by the sentence: ""This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.""?",False, -17882285,Telmisartan affects Albuminuria,2825,"Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.""?",False, -16266744,Telmisartan affects Albuminuria,2826,Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.,"Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.""?",False, -15802746,Telmisartan affects diabetes mellitus,2827,"Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.""?",False, -13992848,Telmisartan affects diabetes mellitus,2828,"Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.""?",False, -13861721,Telmisartan affects type 2 diabetes mellitus,2829,Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.,"Is the triple ""Telmisartan affects type 2 diabetes mellitus"" supported by the sentence: ""Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.""?",False, -13824093,Telmisartan affects Albuminuria,2830,"An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.""?",False, -13501012,Telmisartan affects essential hypertension,2831,CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.,"Is the triple ""Telmisartan affects essential hypertension"" supported by the sentence: ""CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.""?",False, -13178302,Telmisartan affects hypertensive disorder,2832,"In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.","Is the triple ""Telmisartan affects hypertensive disorder"" supported by the sentence: ""In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.""?",False, -25051574,Telmisartan disrupts Alzheimer disease,2833,"RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).","Is the triple ""Telmisartan disrupts Alzheimer disease"" supported by the sentence: ""RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).""?",False, -14418891,Telmisartan disrupts Albuminuria,2834,RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.,"Is the triple ""Telmisartan disrupts Albuminuria"" supported by the sentence: ""RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.""?",False, -13325686,Telmisartan disrupts hypertensive disorder,2835,"WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.","Is the triple ""Telmisartan disrupts hypertensive disorder"" supported by the sentence: ""WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.""?",False, -21182197,Telmisartan prevents Alzheimer disease,2836,Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.,"Is the triple ""Telmisartan prevents Alzheimer disease"" supported by the sentence: ""Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.""?",False, -17513403,Telmisartan prevents myocardial infarction,2837,This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.,"Is the triple ""Telmisartan prevents myocardial infarction"" supported by the sentence: ""This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.""?",False, -17170882,Telmisartan prevents type 2 diabetes mellitus,2838,"OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).","Is the triple ""Telmisartan prevents type 2 diabetes mellitus"" supported by the sentence: ""OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).""?",False, -13010398,Telmisartan prevents stroke disorder,2839,"The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.","Is the triple ""Telmisartan prevents stroke disorder"" supported by the sentence: ""The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.""?",False, -12278433,Telmisartan prevents diabetic kidney disease,2840,"In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.","Is the triple ""Telmisartan prevents diabetic kidney disease"" supported by the sentence: ""In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.""?",False, -11585228,Telmisartan prevents diabetes mellitus,2841,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents diabetes mellitus"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, -11585227,Telmisartan prevents cardiovascular disorder,2842,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents cardiovascular disorder"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, -11473935,Telmisartan prevents hypertensive disorder,2843,"In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.","Is the triple ""Telmisartan prevents hypertensive disorder"" supported by the sentence: ""In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.""?",False, -17028323,Telmisartan predisposes stroke disorder,2844,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes stroke disorder"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, -17028322,Telmisartan predisposes myocardial infarction,2845,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes myocardial infarction"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, -21651336,Irbesartan causes hypertensive disorder,2846,"The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.","Is the triple ""Irbesartan causes hypertensive disorder"" supported by the sentence: ""The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.""?",False, -19454247,Irbesartan affects Sepsis,2847,Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.,"Is the triple ""Irbesartan affects Sepsis"" supported by the sentence: ""Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.""?",False, -13143483,Irbesartan affects type 2 diabetes mellitus,2848,CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.,"Is the triple ""Irbesartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.""?",False, -9015828,Irbesartan affects chronic kidney disease,2849,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects chronic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, -9015827,Irbesartan affects diabetic kidney disease,2850,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects diabetic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, -7812861,Irbesartan affects acute kidney failure,2851,[Acute renal failure associated with irbesartan].,"Is the triple ""Irbesartan affects acute kidney failure"" supported by the sentence: ""[Acute renal failure associated with irbesartan].""?",False, -19016605,Irbesartan disrupts atrial fibrillation,2852,Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.,"Is the triple ""Irbesartan disrupts atrial fibrillation"" supported by the sentence: ""Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.""?",False, -11936096,Irbesartan disrupts hypertensive disorder,2853,"Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.","Is the triple ""Irbesartan disrupts hypertensive disorder"" supported by the sentence: ""Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.""?",False, -9297339,Irbesartan disrupts diabetic kidney disease,2854,Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.,"Is the triple ""Irbesartan disrupts diabetic kidney disease"" supported by the sentence: ""Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.""?",False, -11467158,Irbesartan prevents chronic kidney disease,2855,"In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.","Is the triple ""Irbesartan prevents chronic kidney disease"" supported by the sentence: ""In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.""?",False, -9856662,Irbesartan prevents diabetic kidney disease,2856,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Irbesartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, -8753962,Irbesartan prevents hypertensive disorder,2857,Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.,"Is the triple ""Irbesartan prevents hypertensive disorder"" supported by the sentence: ""Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.""?",False, -15497727,Irbesartan predisposes cardiovascular disorder,2858,"PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.","Is the triple ""Irbesartan predisposes cardiovascular disorder"" supported by the sentence: ""PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.""?",False, -12041301,Irbesartan predisposes IgA glomerulonephritis,2859,OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.,"Is the triple ""Irbesartan predisposes IgA glomerulonephritis"" supported by the sentence: ""OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.""?",False, -9459261,Eprosartan related to essential hypertension,2860,Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.,"Is the triple ""Eprosartan related to essential hypertension"" supported by the sentence: ""Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.""?",False, -8111433,Valsartan related to essential hypertension,2861,"While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.","Is the triple ""Valsartan related to essential hypertension"" supported by the sentence: ""While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.""?",False, -18505936,Valsartan causes myocardial infarction,2862,Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.,"Is the triple ""Valsartan causes myocardial infarction"" supported by the sentence: ""Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.""?",False, -13301661,Valsartan causes diabetes mellitus,2863,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Valsartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, -18533693,Valsartan affects hypertensive disorder,2864,"TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.","Is the triple ""Valsartan affects hypertensive disorder"" supported by the sentence: ""TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.""?",False, -18130226,Valsartan affects stroke disorder,2865,"We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.","Is the triple ""Valsartan affects stroke disorder"" supported by the sentence: ""We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.""?",False, -16609149,Valsartan affects kidney disorder,2866,"This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.","Is the triple ""Valsartan affects kidney disorder"" supported by the sentence: ""This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.""?",False, -9837968,Valsartan affects Abnormal left ventricular function,2867,Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.,"Is the triple ""Valsartan affects Abnormal left ventricular function"" supported by the sentence: ""Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.""?",False, -15479686,Valsartan disrupts type 2 diabetes mellitus,2868,These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.,"Is the triple ""Valsartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.""?",False, -11438135,Valsartan disrupts atherosclerosis,2869,"Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.","Is the triple ""Valsartan disrupts atherosclerosis"" supported by the sentence: ""Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.""?",False, -20671333,Valsartan prevents Abnormal left ventricular function,2870,"CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.","Is the triple ""Valsartan prevents Abnormal left ventricular function"" supported by the sentence: ""CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.""?",False, -15012324,Valsartan prevents type 2 diabetes mellitus,2871,"In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.","Is the triple ""Valsartan prevents type 2 diabetes mellitus"" supported by the sentence: ""In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.""?",False, -13899819,Valsartan prevents stroke disorder,2872,"Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.","Is the triple ""Valsartan prevents stroke disorder"" supported by the sentence: ""Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.""?",False, -12374506,Valsartan prevents diabetes mellitus,2873,"Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.","Is the triple ""Valsartan prevents diabetes mellitus"" supported by the sentence: ""Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.""?",False, -12038680,Valsartan prevents myocardial infarction,2874,"For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.","Is the triple ""Valsartan prevents myocardial infarction"" supported by the sentence: ""For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.""?",False, -11801448,Valsartan prevents atrial fibrillation,2875,CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.,"Is the triple ""Valsartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.""?",False, -8617185,Valsartan prevents coronary artery disorder,2876,"Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.","Is the triple ""Valsartan prevents coronary artery disorder"" supported by the sentence: ""Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.""?",False, -7691192,Valsartan prevents hypertensive disorder,2877,"Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.","Is the triple ""Valsartan prevents hypertensive disorder"" supported by the sentence: ""Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.""?",False, -7604460,Valsartan prevents atherosclerosis,2878,CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.,"Is the triple ""Valsartan prevents atherosclerosis"" supported by the sentence: ""CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.""?",False, -21524148,Valsartan predisposes myocardial infarction,2879,"Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).","Is the triple ""Valsartan predisposes myocardial infarction"" supported by the sentence: ""Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).""?",False, -11133518,Valsartan predisposes cardiovascular disorder,2880,"Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.","Is the triple ""Valsartan predisposes cardiovascular disorder"" supported by the sentence: ""Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.""?",False, -13065808,Losartan related to non-alcoholic fatty liver disease,2881,"AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.","Is the triple ""Losartan related to non-alcoholic fatty liver disease"" supported by the sentence: ""AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.""?",False, -12094342,Losartan related to proteinuria,2882,"The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.","Is the triple ""Losartan related to proteinuria"" supported by the sentence: ""The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.""?",False, -11472713,Losartan related to kidney disorder,2883,Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.,"Is the triple ""Losartan related to kidney disorder"" supported by the sentence: ""Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.""?",False, -10013644,Losartan related to hypertensive disorder,2884,"OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.","Is the triple ""Losartan related to hypertensive disorder"" supported by the sentence: ""OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.""?",False, -8975375,Losartan related to IgA glomerulonephritis,2885,Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.,"Is the triple ""Losartan related to IgA glomerulonephritis"" supported by the sentence: ""Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.""?",False, -16215194,Losartan causes injury,2886,"METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.","Is the triple ""Losartan causes injury"" supported by the sentence: ""METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.""?",False, -15690681,Losartan causes kidney disorder,2887,"Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.","Is the triple ""Losartan causes kidney disorder"" supported by the sentence: ""Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.""?",False, -9749061,Losartan causes hypertensive disorder,2888,Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.,"Is the triple ""Losartan causes hypertensive disorder"" supported by the sentence: ""Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.""?",False, -7310301,Losartan causes proteinuria,2889,"In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.","Is the triple ""Losartan causes proteinuria"" supported by the sentence: ""In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.""?",False, -7204638,Losartan causes Left ventricular hypertrophy,2890,The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.,"Is the triple ""Losartan causes Left ventricular hypertrophy"" supported by the sentence: ""The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.""?",False, -26608778,Losartan affects essential hypertension,2891,The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.,"Is the triple ""Losartan affects essential hypertension"" supported by the sentence: ""The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.""?",False, -24425437,Losartan affects cystic fibrosis,2892,Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.,"Is the triple ""Losartan affects cystic fibrosis"" supported by the sentence: ""Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.""?",False, -21888728,Losartan affects proteinuria,2893,"Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.""?",False, -20488125,Losartan affects hypertensive disorder,2894,"The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.","Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.""?",False, -19990804,Losartan affects aortic valve insufficiency,2895,Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.,"Is the triple ""Losartan affects aortic valve insufficiency"" supported by the sentence: ""Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.""?",False, -18707849,Losartan affects hypertrophic cardiomyopathy,2896,Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.,"Is the triple ""Losartan affects hypertrophic cardiomyopathy"" supported by the sentence: ""Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.""?",False, -16976701,Losartan affects IgA glomerulonephritis,2897,CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.,"Is the triple ""Losartan affects IgA glomerulonephritis"" supported by the sentence: ""CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.""?",False, -13986638,Losartan affects adult acute respiratory distress syndrome,2898,This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.,"Is the triple ""Losartan affects adult acute respiratory distress syndrome"" supported by the sentence: ""This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.""?",False, -13539739,Losartan affects proteinuria,2899,"Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.""?",False, -13498248,Losartan affects Inflammation,2900,"Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.","Is the triple ""Losartan affects Inflammation"" supported by the sentence: ""Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.""?",False, -12531070,Losartan affects Left ventricular hypertrophy,2901,Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.,"Is the triple ""Losartan affects Left ventricular hypertrophy"" supported by the sentence: ""Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.""?",False, -10809955,Losartan affects hypertensive disorder,2902,Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).,"Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).""?",False, -9615315,Losartan affects diabetic kidney disease,2903,Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?,"Is the triple ""Losartan affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?""?",False, -9459571,Losartan affects type 2 diabetes mellitus,2904,CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.""?",False, -9229634,Losartan affects kidney disorder,2905,Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.,"Is the triple ""Losartan affects kidney disorder"" supported by the sentence: ""Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.""?",False, -8678480,Losartan affects injury,2906,"Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.","Is the triple ""Losartan affects injury"" supported by the sentence: ""Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.""?",False, -8551167,Losartan affects type 2 diabetes mellitus,2907,METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.""?",False, -18715311,Losartan disrupts breast neoplasm,2908,"In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.","Is the triple ""Losartan disrupts breast neoplasm"" supported by the sentence: ""In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.""?",False, -14458903,Losartan disrupts pancreatic neoplasm,2909,"When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.","Is the triple ""Losartan disrupts pancreatic neoplasm"" supported by the sentence: ""When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.""?",False, -13976332,Losartan disrupts diabetic kidney disease,2910,OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.,"Is the triple ""Losartan disrupts diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.""?",False, -12949848,Losartan disrupts Inflammation,2911,"Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.","Is the triple ""Losartan disrupts Inflammation"" supported by the sentence: ""Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.""?",False, -9870082,Losartan disrupts hypertensive disorder,2912,Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).,"Is the triple ""Losartan disrupts hypertensive disorder"" supported by the sentence: ""Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).""?",False, -9655766,Losartan disrupts type 2 diabetes mellitus,2913,"Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.","Is the triple ""Losartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.""?",False, -8325352,Losartan disrupts Left ventricular hypertrophy,2914,"Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.","Is the triple ""Losartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.""?",False, -7975855,Losartan disrupts injury,2915,Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.,"Is the triple ""Losartan disrupts injury"" supported by the sentence: ""Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.""?",False, -7310299,Losartan disrupts proteinuria,2916,"CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.","Is the triple ""Losartan disrupts proteinuria"" supported by the sentence: ""CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.""?",False, -21356716,Losartan prevents post-traumatic stress disorder,2917,"We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.","Is the triple ""Losartan prevents post-traumatic stress disorder"" supported by the sentence: ""We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.""?",False, -14540327,Losartan prevents kidney disorder,2918,BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.,"Is the triple ""Losartan prevents kidney disorder"" supported by the sentence: ""BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.""?",False, -12407992,Losartan prevents Inflammation,2919,"RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.","Is the triple ""Losartan prevents Inflammation"" supported by the sentence: ""RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.""?",False, -10030687,Losartan prevents cardiovascular disorder,2920,Losartan vs atenolol in prevention of stroke and cardiovascular disease.,"Is the triple ""Losartan prevents cardiovascular disorder"" supported by the sentence: ""Losartan vs atenolol in prevention of stroke and cardiovascular disease.""?",False, -9856661,Losartan prevents diabetic kidney disease,2921,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Losartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, -9773800,Losartan prevents Left ventricular hypertrophy,2922,Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.,"Is the triple ""Losartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.""?",False, -9766007,Losartan prevents adult acute respiratory distress syndrome,2923,"Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.","Is the triple ""Losartan prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.""?",False, -9420091,Losartan prevents Stenosis,2924,The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.,"Is the triple ""Losartan prevents Stenosis"" supported by the sentence: ""The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.""?",False, -9077908,Losartan prevents proteinuria,2925,"Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.","Is the triple ""Losartan prevents proteinuria"" supported by the sentence: ""Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.""?",False, -8542944,Losartan prevents injury,2926,Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.,"Is the triple ""Losartan prevents injury"" supported by the sentence: ""Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.""?",False, -7768196,Losartan prevents hypertensive disorder,2927,"RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.","Is the triple ""Losartan prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.""?",False, -14272023,Losartan predisposes kidney disorder,2928,"Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.","Is the triple ""Losartan predisposes kidney disorder"" supported by the sentence: ""Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.""?",False, -12616336,Losartan predisposes cardiovascular disorder,2929,"Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.","Is the triple ""Losartan predisposes cardiovascular disorder"" supported by the sentence: ""Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.""?",False, -9964252,Losartan predisposes Left ventricular hypertrophy,2930,"In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).","Is the triple ""Losartan predisposes Left ventricular hypertrophy"" supported by the sentence: ""In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).""?",False, -20586471,Dronabinol related to multiple sclerosis,2931,A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.,"Is the triple ""Dronabinol related to multiple sclerosis"" supported by the sentence: ""A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.""?",False, -25459397,Dronabinol causes cannabis dependence,2932,"BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.","Is the triple ""Dronabinol causes cannabis dependence"" supported by the sentence: ""BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.""?",False, -22027243,Dronabinol causes Nausea,2933,"CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.","Is the triple ""Dronabinol causes Nausea"" supported by the sentence: ""CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.""?",False, -17252204,Dronabinol causes schizophrenia,2934,"Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.","Is the triple ""Dronabinol causes schizophrenia"" supported by the sentence: ""Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.""?",False, -12205989,Dronabinol causes Cognitive impairment,2935,"Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.","Is the triple ""Dronabinol causes Cognitive impairment"" supported by the sentence: ""Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.""?",False, -27448088,Dronabinol affects Anorexia,2936,Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.,"Is the triple ""Dronabinol affects Anorexia"" supported by the sentence: ""Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.""?",False, -25890458,Dronabinol affects Nausea,2937,"Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.","Is the triple ""Dronabinol affects Nausea"" supported by the sentence: ""Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.""?",False, -21879717,Dronabinol affects anorexia nervosa,2938,"The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.","Is the triple ""Dronabinol affects anorexia nervosa"" supported by the sentence: ""The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.""?",False, -20855895,Dronabinol affects neoplasm,2939,"Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.","Is the triple ""Dronabinol affects neoplasm"" supported by the sentence: ""Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.""?",False, -19991701,Dronabinol affects obstructive sleep apnea syndrome,2940,"Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.","Is the triple ""Dronabinol affects obstructive sleep apnea syndrome"" supported by the sentence: ""Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.""?",False, -19474044,Dronabinol affects multiple sclerosis,2941,Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.,"Is the triple ""Dronabinol affects multiple sclerosis"" supported by the sentence: ""Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.""?",False, -16547908,Dronabinol affects schizophrenia,2942,"CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.""?",False, -14443952,Dronabinol affects opiate dependence,2943,Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.,"Is the triple ""Dronabinol affects opiate dependence"" supported by the sentence: ""Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.""?",False, -13958866,Dronabinol affects Cognitive impairment,2944,"Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.","Is the triple ""Dronabinol affects Cognitive impairment"" supported by the sentence: ""Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.""?",False, -13933776,Dronabinol affects schizophrenia,2945,"This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.""?",False, -11304843,Dronabinol affects neuralgia,2946,OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.,"Is the triple ""Dronabinol affects neuralgia"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.""?",False, -11058493,Dronabinol affects Pain,2947,"THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.","Is the triple ""Dronabinol affects Pain"" supported by the sentence: ""THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.""?",False, -24013541,Dronabinol disrupts Pain,2948,"Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.","Is the triple ""Dronabinol disrupts Pain"" supported by the sentence: ""Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.""?",False, -17477155,Dronabinol disrupts HIV infectious disease,2949,"Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.","Is the triple ""Dronabinol disrupts HIV infectious disease"" supported by the sentence: ""Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.""?",False, -11615857,Dronabinol disrupts Nausea,2950,"The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.","Is the triple ""Dronabinol disrupts Nausea"" supported by the sentence: ""The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.""?",False, -25196408,Dronabinol prevents dementia,2951,Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.,"Is the triple ""Dronabinol prevents dementia"" supported by the sentence: ""Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.""?",False, -25026370,Dronabinol prevents neuralgia,2952,We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.,"Is the triple ""Dronabinol prevents neuralgia"" supported by the sentence: ""We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.""?",False, -18579580,Dronabinol prevents Postoperative Nausea and Vomiting,2953,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, -18554637,Dronabinol prevents Nausea,2954,"However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.","Is the triple ""Dronabinol prevents Nausea"" supported by the sentence: ""However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.""?",False, -17477149,Dronabinol prevents HIV infectious disease,2955,THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.,"Is the triple ""Dronabinol prevents HIV infectious disease"" supported by the sentence: ""THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.""?",False, -9671016,Dronabinol prevents Pain,2956,"There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.","Is the triple ""Dronabinol prevents Pain"" supported by the sentence: ""There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.""?",False, -22976957,Dronabinol predisposes Cognitive impairment,2957,"The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.","Is the triple ""Dronabinol predisposes Cognitive impairment"" supported by the sentence: ""The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.""?",False, -18579581,Dronabinol predisposes Postoperative Nausea and Vomiting,2958,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol predisposes Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, -26722658,Cesamet affects Postoperative Nausea and Vomiting,2959,"In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).","Is the triple ""Cesamet affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).""?",False, -26699974,Cesamet affects Nausea,2960,Effect of nabilone on nausea and vomiting.,"Is the triple ""Cesamet affects Nausea"" supported by the sentence: ""Effect of nabilone on nausea and vomiting.""?",False, -19460580,Cesamet prevents Postoperative Nausea and Vomiting,2961,METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.,"Is the triple ""Cesamet prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.""?",False, -25552574,Aprepitant related to glioblastoma,2962,"The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.","Is the triple ""Aprepitant related to glioblastoma"" supported by the sentence: ""The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.""?",False, -18054447,Aprepitant related to Vomiting,2963,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Vomiting"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, -18054446,Aprepitant related to Nausea,2964,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Nausea"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, -11788538,Aprepitant causes Vomiting,2965,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Vomiting"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, -11788537,Aprepitant causes Nausea,2966,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Nausea"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, -23692862,Aprepitant affects Nausea,2967,"The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.","Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.""?",False, -19750085,Aprepitant affects Postoperative Nausea and Vomiting,2968,"In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.","Is the triple ""Aprepitant affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.""?",False, -17874842,Aprepitant affects Vomiting,2969,"Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.","Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.""?",False, -12562288,Aprepitant affects Nausea,2970,Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.,"Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.""?",False, -11119543,Aprepitant affects Vomiting,2971,Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.,"Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.""?",False, -19013645,Aprepitant disrupts HIV infectious disease,2972,RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.,"Is the triple ""Aprepitant disrupts HIV infectious disease"" supported by the sentence: ""RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.""?",False, -16125731,Aprepitant disrupts Vomiting,2973,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Vomiting"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, -16125730,Aprepitant disrupts Nausea,2974,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Nausea"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, -16513148,Aprepitant prevents Pruritus,2975,"INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.","Is the triple ""Aprepitant prevents Pruritus"" supported by the sentence: ""INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.""?",False, -15868137,Aprepitant prevents Postoperative Nausea and Vomiting,2976,We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.,"Is the triple ""Aprepitant prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.""?",False, -10160541,Aprepitant prevents Vomiting,2977,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Vomiting"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, -10160540,Aprepitant prevents Nausea,2978,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Nausea"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, -20804596,Aprepitant predisposes Nausea,2979,"CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.","Is the triple ""Aprepitant predisposes Nausea"" supported by the sentence: ""CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.""?",False, -22122089,Neratinib affects neoplasm,2980,The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].,"Is the triple ""Neratinib affects neoplasm"" supported by the sentence: ""The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].""?",False, -21597229,Lapatinib related to neoplasm,2981,"Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.","Is the triple ""Lapatinib related to neoplasm"" supported by the sentence: ""Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.""?",False, -13650844,Lapatinib related to non-small cell lung carcinoma,2982,"In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.","Is the triple ""Lapatinib related to non-small cell lung carcinoma"" supported by the sentence: ""In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.""?",False, -18268107,Lapatinib affects neoplasm,2983,Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.,"Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.""?",False, -15442238,Lapatinib affects breast neoplasm,2984,HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.,"Is the triple ""Lapatinib affects breast neoplasm"" supported by the sentence: ""HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.""?",False, -14691634,Lapatinib affects neoplasm,2985,"However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.","Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.""?",False, -17546445,Lapatinib disrupts neoplasm,2986,"Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.","Is the triple ""Lapatinib disrupts neoplasm"" supported by the sentence: ""Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.""?",False, -19410918,Lapatinib prevents breast neoplasm,2987,"Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.","Is the triple ""Lapatinib prevents breast neoplasm"" supported by the sentence: ""Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.""?",False, -19317295,Lapatinib prevents neoplasm,2988,CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.,"Is the triple ""Lapatinib prevents neoplasm"" supported by the sentence: ""CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.""?",False, -16643911,Lapatinib predisposes neoplasm,2989,"We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.","Is the triple ""Lapatinib predisposes neoplasm"" supported by the sentence: ""We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.""?",False, -24360220,Nifurtimox related to human African trypanosomiasis,2990,Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.,"Is the triple ""Nifurtimox related to human African trypanosomiasis"" supported by the sentence: ""Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.""?",False, -25977066,Nifurtimox coexists with Deoxyribonucleic acid,2991,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, -25977066,Nifurtimox coexists with Deoxyribonucleic acid,2992,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, -25822629,Nifurtimox causes Chagas disease,2993,Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.,"Is the triple ""Nifurtimox causes Chagas disease"" supported by the sentence: ""Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.""?",False, -21140520,Nifurtimox affects neuroblastoma,2994,"Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.","Is the triple ""Nifurtimox affects neuroblastoma"" supported by the sentence: ""Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.""?",False, -19390598,Nifurtimox affects trypanosomiasis,2995,"The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.","Is the triple ""Nifurtimox affects trypanosomiasis"" supported by the sentence: ""The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.""?",False, -18236131,Nifurtimox affects Deoxyribonucleic acid,2996,"Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).","Is the triple ""Nifurtimox affects Deoxyribonucleic acid"" supported by the sentence: ""Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).""?",False, -21140519,Nifurtimox disrupts neuroblastoma,2997,"Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.","Is the triple ""Nifurtimox disrupts neuroblastoma"" supported by the sentence: ""Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.""?",False, -16729888,Nifurtimox prevents Chagas disease,2998,"Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.","Is the triple ""Nifurtimox prevents Chagas disease"" supported by the sentence: ""Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.""?",False, -8359719,Nitrofurazone coexists with Deoxyribonucleic acid,2999,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, -8359719,Nitrofurazone coexists with Deoxyribonucleic acid,3000,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, -21506050,Nitrofurazone physically interacts with Deoxyribonucleic acid,3001,"Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.""?",False, -16350865,Nitrofurazone physically interacts with Deoxyribonucleic acid,3002,"In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.""?",False, -26982963,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3003,The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.""?",False, -14891197,SCOPOLAMINE HYDROBROMIDE affects Pain,3004,Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Pain"" supported by the sentence: ""Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.""?",False, -13216168,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3005,The effects of scopolamine on MS were studied in mice and rats.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The effects of scopolamine on MS were studied in mice and rats.""?",False, -9844335,SCOPOLAMINE HYDROBROMIDE affects Drooling,3006,"CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.","Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Drooling"" supported by the sentence: ""CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.""?",False, -11447618,SCOPOLAMINE HYDROBROMIDE prevents Pain,3007,In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Pain"" supported by the sentence: ""In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.""?",False, -11253841,SCOPOLAMINE HYDROBROMIDE prevents Drooling,3008,"Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.","Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Drooling"" supported by the sentence: ""Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.""?",False, -8806634,SCOPOLAMINE HYDROBROMIDE prevents motion sickness,3009,Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents motion sickness"" supported by the sentence: ""Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.""?",False, -26997768,Metopimazine affects Nausea,3010,"RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.","Is the triple ""Metopimazine affects Nausea"" supported by the sentence: ""RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.""?",False, -12265728,Metopimazine prevents Nausea,3011,"This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.","Is the triple ""Metopimazine prevents Nausea"" supported by the sentence: ""This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.""?",False, -27200379,Lincomycin related to osteomyelitis,3012,[Optimal regime of intravenous administration of lincomycin in osteomyelitis].,"Is the triple ""Lincomycin related to osteomyelitis"" supported by the sentence: ""[Optimal regime of intravenous administration of lincomycin in osteomyelitis].""?",False, -9905527,Sulindac causes classic familial adenomatous polyposis,3013,"CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.","Is the triple ""Sulindac causes classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.""?",False, -9905522,Sulindac affects classic familial adenomatous polyposis,3014,Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.""?",False, -8547552,Sulindac affects classic familial adenomatous polyposis,3015,CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.""?",False, -11060423,Sulindac prevents classic familial adenomatous polyposis,3016,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Sulindac prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, -20876966,Ketorolac related to migraine disorder,3017,"Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.","Is the triple ""Ketorolac related to migraine disorder"" supported by the sentence: ""Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.""?",False, -27688883,Ketorolac causes Inflammation,3018,We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.,"Is the triple ""Ketorolac causes Inflammation"" supported by the sentence: ""We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.""?",False, -21368479,Ketorolac causes pancreatitis,3019,Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.,"Is the triple ""Ketorolac causes pancreatitis"" supported by the sentence: ""Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.""?",False, -19597016,Ketorolac causes Miosis,3020,CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.,"Is the triple ""Ketorolac causes Miosis"" supported by the sentence: ""CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.""?",False, -12090892,Ketorolac causes Pain,3021,"However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.","Is the triple ""Ketorolac causes Pain"" supported by the sentence: ""However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.""?",False, -20018980,Ketorolac affects breast neoplasm,3022,The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.,"Is the triple ""Ketorolac affects breast neoplasm"" supported by the sentence: ""The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.""?",False, -19245410,Ketorolac affects Miosis,3023,"Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.","Is the triple ""Ketorolac affects Miosis"" supported by the sentence: ""Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.""?",False, -9719257,Ketorolac affects Pain,3024,Effect of pretreatment with ketorolac on propofol injection pain.,"Is the triple ""Ketorolac affects Pain"" supported by the sentence: ""Effect of pretreatment with ketorolac on propofol injection pain.""?",False, -24071071,Ketorolac disrupts Headache,3025,CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.,"Is the triple ""Ketorolac disrupts Headache"" supported by the sentence: ""CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.""?",False, -24029444,Ketorolac disrupts Inflammation,3026,"Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.","Is the triple ""Ketorolac disrupts Inflammation"" supported by the sentence: ""Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.""?",False, -11549492,Ketorolac disrupts Pain,3027,Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.,"Is the triple ""Ketorolac disrupts Pain"" supported by the sentence: ""Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.""?",False, -11362008,Ketorolac disrupts Back pain,3028,"Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.","Is the triple ""Ketorolac disrupts Back pain"" supported by the sentence: ""Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.""?",False, -24306825,Ketorolac prevents Renal Colic,3029,"Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.","Is the triple ""Ketorolac prevents Renal Colic"" supported by the sentence: ""Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.""?",False, -23612322,Ketorolac prevents Chronic pain,3030,"A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.","Is the triple ""Ketorolac prevents Chronic pain"" supported by the sentence: ""A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.""?",False, -20717559,Ketorolac prevents injury,3031,There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.,"Is the triple ""Ketorolac prevents injury"" supported by the sentence: ""There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.""?",False, -11362007,Ketorolac prevents Back pain,3032,Intradermal ketorolac for reduction of epidural back pain.,"Is the triple ""Ketorolac prevents Back pain"" supported by the sentence: ""Intradermal ketorolac for reduction of epidural back pain.""?",False, -11361661,Ketorolac prevents Inflammation,3033,CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.,"Is the triple ""Ketorolac prevents Inflammation"" supported by the sentence: ""CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.""?",False, -11043378,Ketorolac prevents Headache,3034,"At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).","Is the triple ""Ketorolac prevents Headache"" supported by the sentence: ""At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).""?",False, -7985904,Ketorolac prevents Pain,3035,Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.,"Is the triple ""Ketorolac prevents Pain"" supported by the sentence: ""Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.""?",False, -20028754,Ketorolac predisposes injury,3036,"The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.","Is the triple ""Ketorolac predisposes injury"" supported by the sentence: ""The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.""?",False, -25929768,Sulfadiazine related to congenital toxoplasmosis,3037,"[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].","Is the triple ""Sulfadiazine related to congenital toxoplasmosis"" supported by the sentence: ""[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].""?",False, -16546748,Sulfadiazine related to chorioretinitis,3038,"The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.","Is the triple ""Sulfadiazine related to chorioretinitis"" supported by the sentence: ""The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.""?",False, -27660461,Sulfamethoxazole causes pneumonia,3039,"Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.","Is the triple ""Sulfamethoxazole causes pneumonia"" supported by the sentence: ""Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.""?",False, -24328685,Sulfamethoxazole causes kidney disorder,3040,"In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.","Is the triple ""Sulfamethoxazole causes kidney disorder"" supported by the sentence: ""In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.""?",False, -14835537,Sulfamethoxazole affects cystic fibrosis,3041,The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).,"Is the triple ""Sulfamethoxazole affects cystic fibrosis"" supported by the sentence: ""The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).""?",False, -12226918,Sulfamethoxazole affects ocular toxoplasmosis,3042,PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.,"Is the triple ""Sulfamethoxazole affects ocular toxoplasmosis"" supported by the sentence: ""PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.""?",False, -26634163,Sulfamethoxazole prevents bacterial infectious disease,3043,These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.,"Is the triple ""Sulfamethoxazole prevents bacterial infectious disease"" supported by the sentence: ""These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.""?",False, -23781290,Sulfamethoxazole prevents Infection,3044,"Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.","Is the triple ""Sulfamethoxazole prevents Infection"" supported by the sentence: ""Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.""?",False, -22185408,Sulfamethoxazole prevents pneumocystosis,3045,The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.,"Is the triple ""Sulfamethoxazole prevents pneumocystosis"" supported by the sentence: ""The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.""?",False, -21716989,Glycyrrhizic acid affects osteoarthritis,3046,"However, it has not been reported whether glycyrrhizin has a positive effect on OA development.","Is the triple ""Glycyrrhizic acid affects osteoarthritis"" supported by the sentence: ""However, it has not been reported whether glycyrrhizin has a positive effect on OA development.""?",False, -21716987,Glycyrrhizic acid disrupts osteoarthritis,3047,Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.,"Is the triple ""Glycyrrhizic acid disrupts osteoarthritis"" supported by the sentence: ""Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.""?",False, -13246285,Ciclesonide related to perennial allergic rhinitis,3048,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to perennial allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, -13246284,Ciclesonide related to seasonal allergic rhinitis,3049,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to seasonal allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, -10789097,Ciclesonide related to asthma,3050,[Safety and efficacy of inhaled ciclesonide in asthma].,"Is the triple ""Ciclesonide related to asthma"" supported by the sentence: ""[Safety and efficacy of inhaled ciclesonide in asthma].""?",False, -13334776,Ciclesonide causes asthma,3051,Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.,"Is the triple ""Ciclesonide causes asthma"" supported by the sentence: ""Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.""?",False, -13603690,Ciclesonide affects asthma,3052,Ciclesonide improves measures of small airway involvement in asthma.,"Is the triple ""Ciclesonide affects asthma"" supported by the sentence: ""Ciclesonide improves measures of small airway involvement in asthma.""?",False, -26135729,Flunisolide related to perennial allergic rhinitis,3053,Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.,"Is the triple ""Flunisolide related to perennial allergic rhinitis"" supported by the sentence: ""Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.""?",False, -16438918,Flunisolide related to rhinitis,3054,"Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.","Is the triple ""Flunisolide related to rhinitis"" supported by the sentence: ""Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.""?",False, -7778368,Flunisolide related to asthma,3055,"Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.","Is the triple ""Flunisolide related to asthma"" supported by the sentence: ""Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.""?",False, -12189287,Flunisolide prevents Nasal congestion,3056,"The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.","Is the triple ""Flunisolide prevents Nasal congestion"" supported by the sentence: ""The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.""?",False, -27725383,Etoposide related to hepatoblastoma,3057,"Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.","Is the triple ""Etoposide related to hepatoblastoma"" supported by the sentence: ""Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.""?",False, -27360363,Etoposide related to ependymoma,3058,Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.,"Is the triple ""Etoposide related to ependymoma"" supported by the sentence: ""Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.""?",False, -27062931,Etoposide related to supratentorial primitive neuroectodermal tumor,3059,Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.,"Is the triple ""Etoposide related to supratentorial primitive neuroectodermal tumor"" supported by the sentence: ""Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.""?",False, -26965210,Etoposide related to kidney Wilms tumor,3060,"CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.","Is the triple ""Etoposide related to kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.""?",False, -26632944,Etoposide related to HIV infectious disease,3061,Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.,"Is the triple ""Etoposide related to HIV infectious disease"" supported by the sentence: ""Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.""?",False, -22727077,Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma,3062,"Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.","Is the triple ""Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.""?",False, -21142004,Etoposide related to AIDS,3063,"The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.","Is the triple ""Etoposide related to AIDS"" supported by the sentence: ""The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.""?",False, -20988037,Etoposide related to retinoblastoma,3064,"The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.","Is the triple ""Etoposide related to retinoblastoma"" supported by the sentence: ""The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.""?",False, -20394132,Etoposide related to B-cell neoplasm,3065,"Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.","Is the triple ""Etoposide related to B-cell neoplasm"" supported by the sentence: ""Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.""?",False, -19900770,Etoposide related to myelodysplastic syndrome,3066,Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.,"Is the triple ""Etoposide related to myelodysplastic syndrome"" supported by the sentence: ""Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.""?",False, -18768176,Etoposide related to hematopoietic and lymphoid system neoplasm,3067,"Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.","Is the triple ""Etoposide related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.""?",False, -17380085,Etoposide related to Kaposi's sarcoma,3068,"Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.","Is the triple ""Etoposide related to Kaposi's sarcoma"" supported by the sentence: ""Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.""?",False, -17284305,Etoposide related to bone osteosarcoma,3069,We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.,"Is the triple ""Etoposide related to bone osteosarcoma"" supported by the sentence: ""We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.""?",False, -17191209,Etoposide related to hepatocellular carcinoma,3070,The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).,"Is the triple ""Etoposide related to hepatocellular carcinoma"" supported by the sentence: ""The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).""?",False, -17136035,Etoposide related to diffuse large B-cell lymphoma,3071,"Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).","Is the triple ""Etoposide related to diffuse large B-cell lymphoma"" supported by the sentence: ""Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).""?",False, -16406847,Etoposide related to neuroendocrine carcinoma,3072,"However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.","Is the triple ""Etoposide related to neuroendocrine carcinoma"" supported by the sentence: ""However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.""?",False, -16067960,Etoposide related to cutaneous neuroendocrine carcinoma,3073,"In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.","Is the triple ""Etoposide related to cutaneous neuroendocrine carcinoma"" supported by the sentence: ""In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.""?",False, -15501025,Etoposide related to brain cancer,3074,"Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.","Is the triple ""Etoposide related to brain cancer"" supported by the sentence: ""Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.""?",False, -15141728,Etoposide related to testicular cancer,3075,[Continuous infusion of cisplatin plus etoposide in testicular cancer].,"Is the triple ""Etoposide related to testicular cancer"" supported by the sentence: ""[Continuous infusion of cisplatin plus etoposide in testicular cancer].""?",False, -15031494,Etoposide related to lymphoid leukemia,3076,"Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.","Is the triple ""Etoposide related to lymphoid leukemia"" supported by the sentence: ""Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.""?",False, -14511230,Etoposide related to glioblastoma,3077,Preliminary data by cis-platin and etoposide using in primary glioblastoma.,"Is the triple ""Etoposide related to glioblastoma"" supported by the sentence: ""Preliminary data by cis-platin and etoposide using in primary glioblastoma.""?",False, -14453465,Etoposide related to T-cell non-Hodgkin lymphoma,3078,High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).,"Is the triple ""Etoposide related to T-cell non-Hodgkin lymphoma"" supported by the sentence: ""High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).""?",False, -13764189,"Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive",3079,Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.,"Is the triple ""Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.""?",False, -12298091,Etoposide related to breast neoplasm,3080,"Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.","Is the triple ""Etoposide related to breast neoplasm"" supported by the sentence: ""Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.""?",False, -11028194,Etoposide related to acute lymphoblastic leukemia,3081,"Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.","Is the triple ""Etoposide related to acute lymphoblastic leukemia"" supported by the sentence: ""Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.""?",False, -10672040,Etoposide related to Ewing sarcoma,3082,Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.,"Is the triple ""Etoposide related to Ewing sarcoma"" supported by the sentence: ""Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.""?",False, -10503115,Etoposide related to kidney cancer,3083,We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.,"Is the triple ""Etoposide related to kidney cancer"" supported by the sentence: ""We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.""?",False, -10441577,Etoposide related to chronic myelomonocytic leukemia,3084,"Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.","Is the triple ""Etoposide related to chronic myelomonocytic leukemia"" supported by the sentence: ""Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.""?",False, -10410657,Etoposide related to neutropenia,3085,"The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).","Is the triple ""Etoposide related to neutropenia"" supported by the sentence: ""The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).""?",False, -10182075,Etoposide related to non-Hodgkin lymphoma,3086,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Etoposide related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, -10161953,Etoposide related to squamous cell carcinoma,3087,"Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.","Is the triple ""Etoposide related to squamous cell carcinoma"" supported by the sentence: ""Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.""?",False, -9231982,Etoposide related to carcinoma,3088,"In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].","Is the triple ""Etoposide related to carcinoma"" supported by the sentence: ""In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].""?",False, -9157972,Etoposide related to thymoma,3089,"High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.","Is the triple ""Etoposide related to thymoma"" supported by the sentence: ""High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.""?",False, -9138703,Etoposide related to ovarian cancer,3090,A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.,"Is the triple ""Etoposide related to ovarian cancer"" supported by the sentence: ""A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.""?",False, -9115115,Etoposide related to sarcoma,3091,"The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.","Is the triple ""Etoposide related to sarcoma"" supported by the sentence: ""The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.""?",False, -9024985,Etoposide related to leukemia,3092,The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.,"Is the triple ""Etoposide related to leukemia"" supported by the sentence: ""The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.""?",False, -9008448,Etoposide related to Hodgkins lymphoma,3093,"Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.","Is the triple ""Etoposide related to Hodgkins lymphoma"" supported by the sentence: ""Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.""?",False, -9006645,Etoposide related to neuroblastoma,3094,Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.,"Is the triple ""Etoposide related to neuroblastoma"" supported by the sentence: ""Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.""?",False, -8074798,Etoposide related to medulloblastoma,3095,"When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.","Is the triple ""Etoposide related to medulloblastoma"" supported by the sentence: ""When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.""?",False, -8048523,Etoposide related to lymphoma,3096,Oral etoposide in lymphoma.,"Is the triple ""Etoposide related to lymphoma"" supported by the sentence: ""Oral etoposide in lymphoma.""?",False, -7998504,Etoposide related to plasma cell myeloma,3097,"Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.","Is the triple ""Etoposide related to plasma cell myeloma"" supported by the sentence: ""Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.""?",False, -7989979,Etoposide related to neoplasm,3098,"Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.","Is the triple ""Etoposide related to neoplasm"" supported by the sentence: ""Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.""?",False, -7896801,Etoposide related to adult T-cell leukemia/lymphoma,3099,"Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.","Is the triple ""Etoposide related to adult T-cell leukemia/lymphoma"" supported by the sentence: ""Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.""?",False, -7845509,Etoposide related to glioma,3100,Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.,"Is the triple ""Etoposide related to glioma"" supported by the sentence: ""Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.""?",False, -7810052,Etoposide related to castration-resistant prostate carcinoma,3101,"Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.","Is the triple ""Etoposide related to castration-resistant prostate carcinoma"" supported by the sentence: ""Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.""?",False, -7711547,Etoposide related to acute myeloid leukemia,3102,Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.,"Is the triple ""Etoposide related to acute myeloid leukemia"" supported by the sentence: ""Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.""?",False, -7319060,Etoposide related to small cell lung carcinoma,3103,Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.,"Is the triple ""Etoposide related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.""?",False, -7200681,Etoposide related to non-small cell lung carcinoma,3104,Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.,"Is the triple ""Etoposide related to non-small cell lung carcinoma"" supported by the sentence: ""Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.""?",False, -23328204,Etoposide causes small cell lung carcinoma,3105,This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.,"Is the triple ""Etoposide causes small cell lung carcinoma"" supported by the sentence: ""This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.""?",False, -12215704,Etoposide causes neoplasm,3106,"In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.","Is the triple ""Etoposide causes neoplasm"" supported by the sentence: ""In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.""?",False, -8706370,Etoposide causes neutropenia,3107,"The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.","Is the triple ""Etoposide causes neutropenia"" supported by the sentence: ""The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.""?",False, -7869845,Etoposide causes leukemia,3108,"There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.","Is the triple ""Etoposide causes leukemia"" supported by the sentence: ""There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.""?",False, -7642766,Etoposide causes acute myeloid leukemia,3109,Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.,"Is the triple ""Etoposide causes acute myeloid leukemia"" supported by the sentence: ""Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.""?",False, -27374335,Etoposide affects retinoblastoma,3110,"METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.","Is the triple ""Etoposide affects retinoblastoma"" supported by the sentence: ""METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.""?",False, -26960810,Etoposide affects small cell lung carcinoma,3111,"BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.","Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.""?",False, -25269562,Etoposide affects hemophagocytic syndrome,3112,"She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.","Is the triple ""Etoposide affects hemophagocytic syndrome"" supported by the sentence: ""She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.""?",False, -23238600,Etoposide affects choriocarcinoma,3113,[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].,"Is the triple ""Etoposide affects choriocarcinoma"" supported by the sentence: ""[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].""?",False, -18166706,Etoposide affects neuroblastoma,3114,Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.,"Is the triple ""Etoposide affects neuroblastoma"" supported by the sentence: ""Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.""?",False, -17967080,Etoposide affects leukemia,3115,"Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.""?",False, -17160632,Etoposide affects carcinoma,3116,The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.,"Is the triple ""Etoposide affects carcinoma"" supported by the sentence: ""The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.""?",False, -16724406,Etoposide affects neoplasm,3117,The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.,"Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.""?",False, -16425822,Etoposide affects leukemia,3118,"Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.""?",False, -15965763,Etoposide affects testicular cancer,3119,"Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).","Is the triple ""Etoposide affects testicular cancer"" supported by the sentence: ""Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).""?",False, -12798395,Etoposide affects hematopoietic and lymphoid system neoplasm,3120,Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.,"Is the triple ""Etoposide affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.""?",False, -11699750,Etoposide affects small cell lung carcinoma,3121,CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.,"Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.""?",False, -11396769,Etoposide affects chronic myelomonocytic leukemia,3122,"He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.","Is the triple ""Etoposide affects chronic myelomonocytic leukemia"" supported by the sentence: ""He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.""?",False, -9913818,Etoposide affects acute erythroid leukemia,3123,"Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.","Is the triple ""Etoposide affects acute erythroid leukemia"" supported by the sentence: ""Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.""?",False, -9397866,Etoposide affects fallopian tube neoplasm,3124,Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.,"Is the triple ""Etoposide affects fallopian tube neoplasm"" supported by the sentence: ""Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.""?",False, -9293530,Etoposide affects carcinoid tumor,3125,Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.,"Is the triple ""Etoposide affects carcinoid tumor"" supported by the sentence: ""Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.""?",False, -8200378,Etoposide affects neoplasm,3126,"Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.","Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.""?",False, -8003315,Etoposide affects cutaneous neuroendocrine carcinoma,3127,"We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.","Is the triple ""Etoposide affects cutaneous neuroendocrine carcinoma"" supported by the sentence: ""We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.""?",False, -7908520,Etoposide affects B-cell neoplasm,3128,CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).,"Is the triple ""Etoposide affects B-cell neoplasm"" supported by the sentence: ""CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).""?",False, -24115005,Etoposide disrupts small cell lung carcinoma,3129,In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.,"Is the triple ""Etoposide disrupts small cell lung carcinoma"" supported by the sentence: ""In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.""?",False, -17149618,Etoposide disrupts hemophagocytic syndrome,3130,Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).,"Is the triple ""Etoposide disrupts hemophagocytic syndrome"" supported by the sentence: ""Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).""?",False, -16511954,Etoposide disrupts glioblastoma,3131,"In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.","Is the triple ""Etoposide disrupts glioblastoma"" supported by the sentence: ""In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.""?",False, -16039903,Etoposide disrupts neoplasm,3132,"While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).","Is the triple ""Etoposide disrupts neoplasm"" supported by the sentence: ""While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).""?",False, -14383828,Etoposide disrupts bone osteosarcoma,3133,CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).,"Is the triple ""Etoposide disrupts bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).""?",False, -9134229,Etoposide prevents neoplasm,3134,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Etoposide prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, -22634859,Etoposide predisposes neoplasm,3135,Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.,"Is the triple ""Etoposide predisposes neoplasm"" supported by the sentence: ""Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.""?",False, -18673787,Etoposide predisposes brain cancer,3136,"Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.","Is the triple ""Etoposide predisposes brain cancer"" supported by the sentence: ""Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.""?",False, -16345738,Etoposide predisposes myelodysplastic syndrome,3137,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes myelodysplastic syndrome"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, -16345737,Etoposide predisposes acute myeloid leukemia,3138,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes acute myeloid leukemia"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, -10333072,Etoposide predisposes leukemia,3139,"Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.","Is the triple ""Etoposide predisposes leukemia"" supported by the sentence: ""Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.""?",False, -16677028,Teniposide related to neoplasm,3140,"Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.","Is the triple ""Teniposide related to neoplasm"" supported by the sentence: ""Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.""?",False, -10688707,Teniposide related to lymphoma,3141,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to lymphoma"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, -10688706,Teniposide related to leukemia,3142,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to leukemia"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, -27095076,Teniposide affects leukemia,3143,"These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.","Is the triple ""Teniposide affects leukemia"" supported by the sentence: ""These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.""?",False, -26849066,Teniposide predisposes leukemia,3144,"CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.","Is the triple ""Teniposide predisposes leukemia"" supported by the sentence: ""CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.""?",False, -18768362,Urofollitropin related to hypogonadism,3145,"RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.","Is the triple ""Urofollitropin related to hypogonadism"" supported by the sentence: ""RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.""?",False, -18095820,Urofollitropin related to primary ovarian failure,3146,"In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.","Is the triple ""Urofollitropin related to primary ovarian failure"" supported by the sentence: ""In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.""?",False, -9960851,Urofollitropin related to anovulation,3147,Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.,"Is the triple ""Urofollitropin related to anovulation"" supported by the sentence: ""Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.""?",False, -9716197,Urofollitropin related to female infertility,3148,OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.,"Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.""?",False, -8496709,Urofollitropin related to infertility disorder,3149,"BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.","Is the triple ""Urofollitropin related to infertility disorder"" supported by the sentence: ""BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.""?",False, -8454088,Urofollitropin related to male infertility,3150,Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.,"Is the triple ""Urofollitropin related to male infertility"" supported by the sentence: ""Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.""?",False, -8378642,Urofollitropin related to polycystic ovary syndrome,3151,"From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.","Is the triple ""Urofollitropin related to polycystic ovary syndrome"" supported by the sentence: ""From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.""?",False, -8205307,Urofollitropin related to azoospermia,3152,"Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.","Is the triple ""Urofollitropin related to azoospermia"" supported by the sentence: ""Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.""?",False, -14878529,Urofollitropin related to female infertility,3153,"OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).","Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).""?",False, -9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3154,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, -9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3155,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, -10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3156,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, -10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3157,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, -7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3158,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, -7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3159,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, -7302412,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3160,The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.,"Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.""?",False, -7606444,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3161,"The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.","Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.""?",False, -21372974,Urofollitropin causes polycystic ovary syndrome,3162,"In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.","Is the triple ""Urofollitropin causes polycystic ovary syndrome"" supported by the sentence: ""In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.""?",False, -16723493,Urofollitropin causes hypogonadism,3163,"FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.","Is the triple ""Urofollitropin causes hypogonadism"" supported by the sentence: ""FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.""?",False, -16322495,Urofollitropin causes azoospermia,3164,Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.,"Is the triple ""Urofollitropin causes azoospermia"" supported by the sentence: ""Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.""?",False, -9453052,Urofollitropin causes primary ovarian failure,3165,"An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.","Is the triple ""Urofollitropin causes primary ovarian failure"" supported by the sentence: ""An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.""?",False, -8923757,Urofollitropin causes Pregnancy,3166,"However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.","Is the triple ""Urofollitropin causes Pregnancy"" supported by the sentence: ""However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.""?",False, -8815215,Urofollitropin causes anovulation,3167,"Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.","Is the triple ""Urofollitropin causes anovulation"" supported by the sentence: ""Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.""?",False, -8590972,Urofollitropin causes male infertility,3168,"Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.","Is the triple ""Urofollitropin causes male infertility"" supported by the sentence: ""Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.""?",False, -8270576,Urofollitropin causes infertility disorder,3169,Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.,"Is the triple ""Urofollitropin causes infertility disorder"" supported by the sentence: ""Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.""?",False, -19357829,Urofollitropin affects gonadal disorder,3170,"Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.","Is the triple ""Urofollitropin affects gonadal disorder"" supported by the sentence: ""Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.""?",False, -15865492,Urofollitropin affects polycystic ovary syndrome,3171,"The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.","Is the triple ""Urofollitropin affects polycystic ovary syndrome"" supported by the sentence: ""The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.""?",False, -14984090,Urofollitropin affects male infertility,3172,The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.""?",False, -13249247,Urofollitropin affects Pregnancy,3173,"CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.","Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.""?",False, -10980447,Urofollitropin affects Pregnancy,3174,BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.,"Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.""?",False, -8590971,Urofollitropin affects male infertility,3175,The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.""?",False, -7302415,Urofollitropin affects Follicle Stimulating Hormone Receptor,3176,These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.""?",False, -9844029,Urofollitropin affects Follicle Stimulating Hormone Receptor,3177,This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.""?",False, -27587327,Urofollitropin produces primary ovarian failure,3178,"Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).","Is the triple ""Urofollitropin produces primary ovarian failure"" supported by the sentence: ""Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).""?",False, -20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3179,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, -20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3180,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, -8502213,Urofollitropin produces polycystic ovary syndrome,3181,"RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.","Is the triple ""Urofollitropin produces polycystic ovary syndrome"" supported by the sentence: ""RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.""?",False, -20569186,Urofollitropin disrupts Pregnancy,3182,"RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.","Is the triple ""Urofollitropin disrupts Pregnancy"" supported by the sentence: ""RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.""?",False, -11195885,Urofollitropin prevents azoospermia,3183,"While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.","Is the triple ""Urofollitropin prevents azoospermia"" supported by the sentence: ""While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.""?",False, -17502146,Urofollitropin predisposes azoospermia,3184,"On multivariate analysis, only FSH remained predictive of NOA.","Is the triple ""Urofollitropin predisposes azoospermia"" supported by the sentence: ""On multivariate analysis, only FSH remained predictive of NOA.""?",False, -16417247,Urofollitropin predisposes anovulation,3185,"CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.","Is the triple ""Urofollitropin predisposes anovulation"" supported by the sentence: ""CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.""?",False, -16278695,Urofollitropin predisposes infertility disorder,3186,"The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).","Is the triple ""Urofollitropin predisposes infertility disorder"" supported by the sentence: ""The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).""?",False, -15110465,Urofollitropin predisposes polycystic ovary syndrome,3187,"LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).","Is the triple ""Urofollitropin predisposes polycystic ovary syndrome"" supported by the sentence: ""LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).""?",False, -7379891,Urofollitropin predisposes primary ovarian failure,3188,Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.,"Is the triple ""Urofollitropin predisposes primary ovarian failure"" supported by the sentence: ""Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.""?",False, -23895216,Ivacaftor affects cystic fibrosis,3189,Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.,"Is the triple ""Ivacaftor affects cystic fibrosis"" supported by the sentence: ""Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.""?",False, -20354463,Nitric oxide related to ST-elevation myocardial infarction,3190,The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.,"Is the triple ""Nitric oxide related to ST-elevation myocardial infarction"" supported by the sentence: ""The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.""?",False, -17273075,Nitric oxide related to bronchiolitis,3191,"By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.","Is the triple ""Nitric oxide related to bronchiolitis"" supported by the sentence: ""By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.""?",False, -15880296,Nitric oxide related to Diabetic Foot,3192,"Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).","Is the triple ""Nitric oxide related to Diabetic Foot"" supported by the sentence: ""Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).""?",False, -14910010,Nitric oxide related to severe acute respiratory syndrome,3193,Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.,"Is the triple ""Nitric oxide related to severe acute respiratory syndrome"" supported by the sentence: ""Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.""?",False, -14573099,Nitric oxide related to bronchopulmonary dysplasia,3194,"The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.","Is the triple ""Nitric oxide related to bronchopulmonary dysplasia"" supported by the sentence: ""The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.""?",False, -11752178,Nitric oxide related to cutaneous leishmaniasis,3195,"Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.","Is the triple ""Nitric oxide related to cutaneous leishmaniasis"" supported by the sentence: ""Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.""?",False, -9816415,Nitric oxide related to newborn respiratory distress syndrome,3196,"To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.","Is the triple ""Nitric oxide related to newborn respiratory distress syndrome"" supported by the sentence: ""To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.""?",False, -9774015,Nitric oxide related to respiratory system disorder,3197,Nitric oxide in respiratory diseases.,"Is the triple ""Nitric oxide related to respiratory system disorder"" supported by the sentence: ""Nitric oxide in respiratory diseases.""?",False, -8707490,Nitric oxide related to myocardial infarction,3198,"Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.","Is the triple ""Nitric oxide related to myocardial infarction"" supported by the sentence: ""Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.""?",False, -8593326,Nitric oxide related to neuralgia,3199,This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.,"Is the triple ""Nitric oxide related to neuralgia"" supported by the sentence: ""This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.""?",False, -8476870,Nitric oxide related to lung disorder,3200,"Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.","Is the triple ""Nitric oxide related to lung disorder"" supported by the sentence: ""Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.""?",False, -8350800,Nitric oxide related to opiate dependence,3201,"RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.","Is the triple ""Nitric oxide related to opiate dependence"" supported by the sentence: ""RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.""?",False, -8343542,Nitric oxide related to Varicose Ulcer,3202,"NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.","Is the triple ""Nitric oxide related to Varicose Ulcer"" supported by the sentence: ""NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.""?",False, -8057943,Nitric oxide related to malaria,3203,Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.,"Is the triple ""Nitric oxide related to malaria"" supported by the sentence: ""Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.""?",False, -8040944,Nitric oxide related to sickle cell anemia,3204,Strategies that enhance NO activity may be therapeutic in sickle cell disease.,"Is the triple ""Nitric oxide related to sickle cell anemia"" supported by the sentence: ""Strategies that enhance NO activity may be therapeutic in sickle cell disease.""?",False, -7963930,Nitric oxide related to cystic fibrosis,3205,"As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.","Is the triple ""Nitric oxide related to cystic fibrosis"" supported by the sentence: ""As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.""?",False, -7923041,Nitric oxide related to brain injury,3206,"While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.","Is the triple ""Nitric oxide related to brain injury"" supported by the sentence: ""While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.""?",False, -7788094,Nitric oxide related to myocardial ischemia,3207,"This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.","Is the triple ""Nitric oxide related to myocardial ischemia"" supported by the sentence: ""This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.""?",False, -7738003,Nitric oxide related to Hypoxemia,3208,"In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.","Is the triple ""Nitric oxide related to Hypoxemia"" supported by the sentence: ""In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.""?",False, -7725812,Nitric oxide related to Premature birth,3209,"Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.","Is the triple ""Nitric oxide related to Premature birth"" supported by the sentence: ""Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.""?",False, -7657450,Nitric oxide related to pulmonary embolism,3210,Use of inhaled nitric oxide in pulmonary embolism.,"Is the triple ""Nitric oxide related to pulmonary embolism"" supported by the sentence: ""Use of inhaled nitric oxide in pulmonary embolism.""?",False, -7539810,Nitric oxide related to stroke disorder,3211,The findings indicate the importance of nitric oxide in stroke and ischemia.,"Is the triple ""Nitric oxide related to stroke disorder"" supported by the sentence: ""The findings indicate the importance of nitric oxide in stroke and ischemia.""?",False, -7481315,Nitric oxide related to chronic obstructive pulmonary disease,3212,Exhaled nitric oxide in COPD: glancing through a smoke screen.,"Is the triple ""Nitric oxide related to chronic obstructive pulmonary disease"" supported by the sentence: ""Exhaled nitric oxide in COPD: glancing through a smoke screen.""?",False, -7449413,Nitric oxide related to respiratory failure,3213,Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.,"Is the triple ""Nitric oxide related to respiratory failure"" supported by the sentence: ""Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.""?",False, -7439172,Nitric oxide related to neoplasm,3214,"Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.","Is the triple ""Nitric oxide related to neoplasm"" supported by the sentence: ""Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.""?",False, -7418030,Nitric oxide related to acute kidney failure,3215,BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.,"Is the triple ""Nitric oxide related to acute kidney failure"" supported by the sentence: ""BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.""?",False, -7373096,Nitric oxide related to brain ischemia,3216,"Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.","Is the triple ""Nitric oxide related to brain ischemia"" supported by the sentence: ""Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.""?",False, -7345317,Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins,3217,"CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.","Is the triple ""Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.""?",False, -7242606,Nitric oxide related to adult acute respiratory distress syndrome,3218,Inhaled nitric oxide may also have therapeutic potential in ARDS.,"Is the triple ""Nitric oxide related to adult acute respiratory distress syndrome"" supported by the sentence: ""Inhaled nitric oxide may also have therapeutic potential in ARDS.""?",False, -7159413,Nitric oxide related to Sepsis,3219,"CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.","Is the triple ""Nitric oxide related to Sepsis"" supported by the sentence: ""CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.""?",False, -7145311,Nitric oxide related to Inflammation,3220,Nitric oxide protects in intestinal inflammation.,"Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Nitric oxide protects in intestinal inflammation.""?",False, -7091337,Nitric oxide related to ischemia reperfusion injury,3221,This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.,"Is the triple ""Nitric oxide related to ischemia reperfusion injury"" supported by the sentence: ""This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.""?",False, -14184908,Nitric oxide related to Inflammation,3222,"Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.","Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.""?",False, -27698007,Nitric oxide causes lung disorder,3223,"Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.","Is the triple ""Nitric oxide causes lung disorder"" supported by the sentence: ""Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.""?",False, -23636922,Nitric oxide causes Infection,3224,"Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.","Is the triple ""Nitric oxide causes Infection"" supported by the sentence: ""Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.""?",False, -22013082,Nitric oxide causes sickle cell anemia,3225,"Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.","Is the triple ""Nitric oxide causes sickle cell anemia"" supported by the sentence: ""Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.""?",False, -21447838,Nitric oxide causes respiratory system disorder,3226,NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.,"Is the triple ""Nitric oxide causes respiratory system disorder"" supported by the sentence: ""NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.""?",False, -14028136,Nitric oxide causes stroke disorder,3227,"OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.","Is the triple ""Nitric oxide causes stroke disorder"" supported by the sentence: ""OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.""?",False, -12046903,Nitric oxide causes cystic fibrosis,3228,CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.,"Is the triple ""Nitric oxide causes cystic fibrosis"" supported by the sentence: ""CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.""?",False, -11887505,Nitric oxide causes myocardial ischemia,3229,"RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.","Is the triple ""Nitric oxide causes myocardial ischemia"" supported by the sentence: ""RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.""?",False, -11842330,Nitric oxide causes ischemia reperfusion injury,3230,BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).,"Is the triple ""Nitric oxide causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).""?",False, -11556568,Nitric oxide causes acute kidney failure,3231,NO plays a dual role of protection and damage in the pathogenesis of ARF.,"Is the triple ""Nitric oxide causes acute kidney failure"" supported by the sentence: ""NO plays a dual role of protection and damage in the pathogenesis of ARF.""?",False, -11353052,Nitric oxide causes adult acute respiratory distress syndrome,3232,"CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.","Is the triple ""Nitric oxide causes adult acute respiratory distress syndrome"" supported by the sentence: ""CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.""?",False, -9962165,Nitric oxide causes malaria,3233,We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.,"Is the triple ""Nitric oxide causes malaria"" supported by the sentence: ""We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.""?",False, -9795722,Nitric oxide causes neuralgia,3234,OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.,"Is the triple ""Nitric oxide causes neuralgia"" supported by the sentence: ""OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.""?",False, -9068211,Nitric oxide causes pneumonia,3235,"A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.","Is the triple ""Nitric oxide causes pneumonia"" supported by the sentence: ""A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.""?",False, -8934561,Nitric oxide causes brain injury,3236,"It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.","Is the triple ""Nitric oxide causes brain injury"" supported by the sentence: ""It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.""?",False, -8855613,Nitric oxide causes neoplasm,3237,Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.,"Is the triple ""Nitric oxide causes neoplasm"" supported by the sentence: ""Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.""?",False, -8834736,Nitric oxide causes myocardial infarction,3238,"Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.","Is the triple ""Nitric oxide causes myocardial infarction"" supported by the sentence: ""Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.""?",False, -8346309,Nitric oxide causes Premature birth,3239,The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.,"Is the triple ""Nitric oxide causes Premature birth"" supported by the sentence: ""The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.""?",False, -8185371,Nitric oxide causes Inflammation,3240,Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.,"Is the triple ""Nitric oxide causes Inflammation"" supported by the sentence: ""Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.""?",False, -8037779,Nitric oxide causes brain ischemia,3241,"Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.","Is the triple ""Nitric oxide causes brain ischemia"" supported by the sentence: ""Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.""?",False, -7409857,Nitric oxide causes Sepsis,3242,Nitric oxide in the pathogenesis of sepsis.,"Is the triple ""Nitric oxide causes Sepsis"" supported by the sentence: ""Nitric oxide in the pathogenesis of sepsis.""?",False, -7184490,Nitric oxide causes Hypoxemia,3243,These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.,"Is the triple ""Nitric oxide causes Hypoxemia"" supported by the sentence: ""These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.""?",False, -27626134,Nitric oxide affects cystic fibrosis,3244,"We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.","Is the triple ""Nitric oxide affects cystic fibrosis"" supported by the sentence: ""We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.""?",False, -27208311,Nitric oxide affects opiate dependence,3245,"NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.","Is the triple ""Nitric oxide affects opiate dependence"" supported by the sentence: ""NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.""?",False, -27058878,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3246,The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.,"Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.""?",False, -20413999,Nitric oxide affects brain injury,3247,"Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.","Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.""?",False, -19764415,Nitric oxide affects pneumonia,3248,"Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.""?",False, -18632674,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3249,"We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.","Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.""?",False, -17798838,Nitric oxide affects neuralgia,3250,"All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.","Is the triple ""Nitric oxide affects neuralgia"" supported by the sentence: ""All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.""?",False, -17030125,Nitric oxide affects bronchiolitis,3251,Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.,"Is the triple ""Nitric oxide affects bronchiolitis"" supported by the sentence: ""Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.""?",False, -12566083,Nitric oxide affects respiratory system disorder,3252,Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.,"Is the triple ""Nitric oxide affects respiratory system disorder"" supported by the sentence: ""Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.""?",False, -11778681,Nitric oxide affects stroke disorder,3253,Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.,"Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.""?",False, -11521495,Nitric oxide affects severe acute respiratory syndrome,3254,"These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.","Is the triple ""Nitric oxide affects severe acute respiratory syndrome"" supported by the sentence: ""These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.""?",False, -11353389,Nitric oxide affects myocardial infarction,3255,Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.,"Is the triple ""Nitric oxide affects myocardial infarction"" supported by the sentence: ""Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.""?",False, -10403969,Nitric oxide affects anemia,3256,"Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.""?",False, -10222313,Nitric oxide affects ischemia reperfusion injury,3257,CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.,"Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.""?",False, -10099288,Nitric oxide affects myocardial ischemia,3258,Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.""?",False, -10018002,Nitric oxide affects acute kidney failure,3259,"Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.","Is the triple ""Nitric oxide affects acute kidney failure"" supported by the sentence: ""Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.""?",False, -10008267,Nitric oxide affects lung disorder,3260,"Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.","Is the triple ""Nitric oxide affects lung disorder"" supported by the sentence: ""Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.""?",False, -9982988,Nitric oxide affects respiratory failure,3261,Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.,"Is the triple ""Nitric oxide affects respiratory failure"" supported by the sentence: ""Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.""?",False, -9910920,Nitric oxide affects brain ischemia,3262,These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.,"Is the triple ""Nitric oxide affects brain ischemia"" supported by the sentence: ""These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.""?",False, -9742582,Nitric oxide affects stroke disorder,3263,"The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.","Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.""?",False, -9649727,Nitric oxide affects neoplasm,3264,Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.""?",False, -9102608,Nitric oxide affects Hypoxemia,3265,Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.,"Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.""?",False, -9095187,Nitric oxide affects newborn respiratory distress syndrome,3266,"There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.","Is the triple ""Nitric oxide affects newborn respiratory distress syndrome"" supported by the sentence: ""There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.""?",False, -8891949,Nitric oxide affects Sepsis,3267,"Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.""?",False, -8832872,Nitric oxide affects pneumonia,3268,"The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.""?",False, -8646255,Nitric oxide affects myocardial ischemia,3269,The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.""?",False, -8473168,Nitric oxide affects neoplasm,3270,NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.""?",False, -8202584,Nitric oxide affects Sepsis,3271,"Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.""?",False, -8139693,Nitric oxide affects brain injury,3272,Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.,"Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.""?",False, -7935763,Nitric oxide affects chronic obstructive pulmonary disease,3273,The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.""?",False, -7896362,Nitric oxide affects Inflammation,3274,"Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.","Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.""?",False, -7780898,Nitric oxide affects chronic obstructive pulmonary disease,3275,Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.""?",False, -7712088,Nitric oxide affects Hypoxemia,3276,"By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.","Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.""?",False, -7542916,Nitric oxide affects anemia,3277,"Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).""?",False, -7169788,Nitric oxide affects Inflammation,3278,Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.,"Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.""?",False, -7164340,Nitric oxide affects ischemia reperfusion injury,3279,"The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.","Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.""?",False, -7094195,Nitric oxide affects malaria,3280,Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.,"Is the triple ""Nitric oxide affects malaria"" supported by the sentence: ""Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.""?",False, -20359925,Nitric oxide produces chronic obstructive pulmonary disease,3281,"However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.","Is the triple ""Nitric oxide produces chronic obstructive pulmonary disease"" supported by the sentence: ""However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.""?",False, -20299429,Nitric oxide produces pneumonia,3282,We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.,"Is the triple ""Nitric oxide produces pneumonia"" supported by the sentence: ""We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.""?",False, -17925357,Nitric oxide produces bronchopulmonary dysplasia,3283,"The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.","Is the triple ""Nitric oxide produces bronchopulmonary dysplasia"" supported by the sentence: ""The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.""?",False, -15219259,Nitric oxide produces Premature birth,3284,CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.,"Is the triple ""Nitric oxide produces Premature birth"" supported by the sentence: ""CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.""?",False, -13106727,Nitric oxide produces adult acute respiratory distress syndrome,3285,"Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.","Is the triple ""Nitric oxide produces adult acute respiratory distress syndrome"" supported by the sentence: ""Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.""?",False, -12774415,Nitric oxide produces stroke disorder,3286,The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.,"Is the triple ""Nitric oxide produces stroke disorder"" supported by the sentence: ""The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.""?",False, -12205025,Nitric oxide produces Varicose Ulcer,3287,"The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.","Is the triple ""Nitric oxide produces Varicose Ulcer"" supported by the sentence: ""The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.""?",False, -11786457,Nitric oxide produces brain ischemia,3288,"One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.","Is the triple ""Nitric oxide produces brain ischemia"" supported by the sentence: ""One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.""?",False, -9816411,Nitric oxide produces newborn respiratory distress syndrome,3289,Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.,"Is the triple ""Nitric oxide produces newborn respiratory distress syndrome"" supported by the sentence: ""Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.""?",False, -8745644,Nitric oxide produces sickle cell anemia,3290,We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.,"Is the triple ""Nitric oxide produces sickle cell anemia"" supported by the sentence: ""We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.""?",False, -8339020,Nitric oxide produces acute kidney failure,3291,"In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.","Is the triple ""Nitric oxide produces acute kidney failure"" supported by the sentence: ""In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.""?",False, -7963932,Nitric oxide produces cystic fibrosis,3292,The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.,"Is the triple ""Nitric oxide produces cystic fibrosis"" supported by the sentence: ""The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.""?",False, -7644756,Nitric oxide produces anemia,3293,"Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.","Is the triple ""Nitric oxide produces anemia"" supported by the sentence: ""Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.""?",False, -7555266,Nitric oxide produces myocardial ischemia,3294,Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.,"Is the triple ""Nitric oxide produces myocardial ischemia"" supported by the sentence: ""Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.""?",False, -7511323,Nitric oxide produces myocardial infarction,3295,"The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).","Is the triple ""Nitric oxide produces myocardial infarction"" supported by the sentence: ""The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).""?",False, -7507297,Nitric oxide produces Inflammation,3296,Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.,"Is the triple ""Nitric oxide produces Inflammation"" supported by the sentence: ""Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.""?",False, -7461061,Nitric oxide produces Hypoxemia,3297,"Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.","Is the triple ""Nitric oxide produces Hypoxemia"" supported by the sentence: ""Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.""?",False, -7435212,Nitric oxide produces neoplasm,3298,"Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.","Is the triple ""Nitric oxide produces neoplasm"" supported by the sentence: ""Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.""?",False, -7390889,Nitric oxide produces Sepsis,3299,"In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.","Is the triple ""Nitric oxide produces Sepsis"" supported by the sentence: ""In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.""?",False, -7094197,Nitric oxide produces malaria,3300,"However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.","Is the triple ""Nitric oxide produces malaria"" supported by the sentence: ""However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.""?",False, -26705109,Nitric oxide disrupts anemia,3301,"NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.","Is the triple ""Nitric oxide disrupts anemia"" supported by the sentence: ""NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.""?",False, -19923810,Nitric oxide disrupts stroke disorder,3302,"CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.","Is the triple ""Nitric oxide disrupts stroke disorder"" supported by the sentence: ""CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.""?",False, -14786185,Nitric oxide disrupts Sepsis,3303,Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.,"Is the triple ""Nitric oxide disrupts Sepsis"" supported by the sentence: ""Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.""?",False, -12247489,Nitric oxide disrupts sickle cell anemia,3304,"Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.","Is the triple ""Nitric oxide disrupts sickle cell anemia"" supported by the sentence: ""Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.""?",False, -11088644,Nitric oxide disrupts cystic fibrosis,3305,"Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.","Is the triple ""Nitric oxide disrupts cystic fibrosis"" supported by the sentence: ""Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.""?",False, -10963665,Nitric oxide disrupts neoplasm,3306,"Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.","Is the triple ""Nitric oxide disrupts neoplasm"" supported by the sentence: ""Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.""?",False, -10158293,Nitric oxide disrupts myocardial ischemia,3307,"Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.","Is the triple ""Nitric oxide disrupts myocardial ischemia"" supported by the sentence: ""Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.""?",False, -9091818,Nitric oxide disrupts respiratory failure,3308,"However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.","Is the triple ""Nitric oxide disrupts respiratory failure"" supported by the sentence: ""However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.""?",False, -8577648,Nitric oxide disrupts Inflammation,3309,In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.,"Is the triple ""Nitric oxide disrupts Inflammation"" supported by the sentence: ""In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.""?",False, -7822328,Nitric oxide disrupts adult acute respiratory distress syndrome,3310,BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).,"Is the triple ""Nitric oxide disrupts adult acute respiratory distress syndrome"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).""?",False, -7750750,Nitric oxide disrupts myocardial infarction,3311,"Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.","Is the triple ""Nitric oxide disrupts myocardial infarction"" supported by the sentence: ""Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.""?",False, -7555296,Nitric oxide disrupts ischemia reperfusion injury,3312,NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.,"Is the triple ""Nitric oxide disrupts ischemia reperfusion injury"" supported by the sentence: ""NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.""?",False, -7358959,Nitric oxide disrupts Hypoxemia,3313,CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.,"Is the triple ""Nitric oxide disrupts Hypoxemia"" supported by the sentence: ""CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.""?",False, -26913950,Nitric oxide prevents adult acute respiratory distress syndrome,3314,"Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.","Is the triple ""Nitric oxide prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.""?",False, -25277893,Nitric oxide prevents neuralgia,3315,"Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.","Is the triple ""Nitric oxide prevents neuralgia"" supported by the sentence: ""Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.""?",False, -22898445,Nitric oxide prevents Infection,3316,The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.,"Is the triple ""Nitric oxide prevents Infection"" supported by the sentence: ""The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.""?",False, -21669107,Nitric oxide prevents neoplasm,3317,"CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.","Is the triple ""Nitric oxide prevents neoplasm"" supported by the sentence: ""CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.""?",False, -21628822,Nitric oxide prevents Hypoxemia,3318,"The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.","Is the triple ""Nitric oxide prevents Hypoxemia"" supported by the sentence: ""The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.""?",False, -21494876,Nitric oxide prevents Inflammation,3319,"This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.","Is the triple ""Nitric oxide prevents Inflammation"" supported by the sentence: ""This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.""?",False, -21062009,Nitric oxide prevents pulmonary embolism,3320,"Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.","Is the triple ""Nitric oxide prevents pulmonary embolism"" supported by the sentence: ""Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.""?",False, -16675253,Nitric oxide prevents stroke disorder,3321,"Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.","Is the triple ""Nitric oxide prevents stroke disorder"" supported by the sentence: ""Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.""?",False, -13634130,Nitric oxide prevents sickle cell anemia,3322,"Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).","Is the triple ""Nitric oxide prevents sickle cell anemia"" supported by the sentence: ""Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).""?",False, -11584828,Nitric oxide prevents brain ischemia,3323,"CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.","Is the triple ""Nitric oxide prevents brain ischemia"" supported by the sentence: ""CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.""?",False, -11450951,Nitric oxide prevents myocardial infarction,3324,BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.,"Is the triple ""Nitric oxide prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.""?",False, -10887585,Nitric oxide prevents pneumonia,3325,"BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.","Is the triple ""Nitric oxide prevents pneumonia"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.""?",False, -9990816,Nitric oxide prevents acute kidney failure,3326,"Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.","Is the triple ""Nitric oxide prevents acute kidney failure"" supported by the sentence: ""Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.""?",False, -9464831,Nitric oxide prevents myocardial ischemia,3327,We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.,"Is the triple ""Nitric oxide prevents myocardial ischemia"" supported by the sentence: ""We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.""?",False, -8988568,Nitric oxide prevents chronic obstructive pulmonary disease,3328,Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).,"Is the triple ""Nitric oxide prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).""?",False, -8396830,Nitric oxide prevents cystic fibrosis,3329,"Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.","Is the triple ""Nitric oxide prevents cystic fibrosis"" supported by the sentence: ""Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.""?",False, -8224065,Nitric oxide prevents brain injury,3330,NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.,"Is the triple ""Nitric oxide prevents brain injury"" supported by the sentence: ""NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.""?",False, -8045867,Nitric oxide prevents lung disorder,3331,These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.,"Is the triple ""Nitric oxide prevents lung disorder"" supported by the sentence: ""These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.""?",False, -7996843,Nitric oxide prevents Sepsis,3332,"One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.","Is the triple ""Nitric oxide prevents Sepsis"" supported by the sentence: ""One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.""?",False, -7713281,Nitric oxide prevents respiratory failure,3333,Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.,"Is the triple ""Nitric oxide prevents respiratory failure"" supported by the sentence: ""Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.""?",False, -7103253,Nitric oxide prevents ischemia reperfusion injury,3334,It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.,"Is the triple ""Nitric oxide prevents ischemia reperfusion injury"" supported by the sentence: ""It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.""?",False, -27558971,Nitric oxide exacerbates myocardial ischemia,3335,Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.,"Is the triple ""Nitric oxide exacerbates myocardial ischemia"" supported by the sentence: ""Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.""?",False, -26883794,Nitric oxide exacerbates acute kidney failure,3336,Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.,"Is the triple ""Nitric oxide exacerbates acute kidney failure"" supported by the sentence: ""Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.""?",False, -24530593,Nitric oxide exacerbates ischemia reperfusion injury,3337,"NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.","Is the triple ""Nitric oxide exacerbates ischemia reperfusion injury"" supported by the sentence: ""NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.""?",False, -23305196,Nitric oxide predisposes cystic fibrosis,3338,"It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.","Is the triple ""Nitric oxide predisposes cystic fibrosis"" supported by the sentence: ""It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.""?",False, -18515843,Nitric oxide predisposes malaria,3339,"We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.","Is the triple ""Nitric oxide predisposes malaria"" supported by the sentence: ""We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.""?",False, -17339126,Nitric oxide predisposes stroke disorder,3340,"OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.","Is the triple ""Nitric oxide predisposes stroke disorder"" supported by the sentence: ""OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.""?",False, -17303048,Nitric oxide predisposes brain ischemia,3341,"To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.","Is the triple ""Nitric oxide predisposes brain ischemia"" supported by the sentence: ""To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.""?",False, -16438716,Nitric oxide predisposes respiratory system disorder,3342,Nitric oxide (NO) is now considered an important biomarker for respiratory disease.,"Is the triple ""Nitric oxide predisposes respiratory system disorder"" supported by the sentence: ""Nitric oxide (NO) is now considered an important biomarker for respiratory disease.""?",False, -16061041,Nitric oxide predisposes lung disorder,3343,"As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.","Is the triple ""Nitric oxide predisposes lung disorder"" supported by the sentence: ""As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.""?",False, -15696584,Nitric oxide predisposes chronic obstructive pulmonary disease,3344,"Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.","Is the triple ""Nitric oxide predisposes chronic obstructive pulmonary disease"" supported by the sentence: ""Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.""?",False, -13236015,Nitric oxide predisposes bronchopulmonary dysplasia,3345,Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.,"Is the triple ""Nitric oxide predisposes bronchopulmonary dysplasia"" supported by the sentence: ""Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.""?",False, -12163328,Nitric oxide predisposes acute kidney failure,3346,"However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).","Is the triple ""Nitric oxide predisposes acute kidney failure"" supported by the sentence: ""However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).""?",False, -12068938,Nitric oxide predisposes neuralgia,3347,"During such processes, NO contributes to the development of neuropathic pain.","Is the triple ""Nitric oxide predisposes neuralgia"" supported by the sentence: ""During such processes, NO contributes to the development of neuropathic pain.""?",False, -11569688,Nitric oxide predisposes Premature birth,3348,CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.,"Is the triple ""Nitric oxide predisposes Premature birth"" supported by the sentence: ""CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.""?",False, -9326529,Nitric oxide predisposes brain injury,3349,"Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.","Is the triple ""Nitric oxide predisposes brain injury"" supported by the sentence: ""Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.""?",False, -8098085,Nitric oxide predisposes neoplasm,3350,These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.,"Is the triple ""Nitric oxide predisposes neoplasm"" supported by the sentence: ""These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.""?",False, -7895713,Nitric oxide predisposes pneumonia,3351,"METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).","Is the triple ""Nitric oxide predisposes pneumonia"" supported by the sentence: ""METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).""?",False, -7863118,Nitric oxide predisposes Hypoxemia,3352,"CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.","Is the triple ""Nitric oxide predisposes Hypoxemia"" supported by the sentence: ""CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.""?",False, -7644760,Nitric oxide predisposes anemia,3353,"After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.","Is the triple ""Nitric oxide predisposes anemia"" supported by the sentence: ""After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.""?",False, -7373094,Nitric oxide predisposes ischemia reperfusion injury,3354,Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.,"Is the triple ""Nitric oxide predisposes ischemia reperfusion injury"" supported by the sentence: ""Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.""?",False, -7119398,Nitric oxide predisposes Inflammation,3355,Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.,"Is the triple ""Nitric oxide predisposes Inflammation"" supported by the sentence: ""Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.""?",False, -18948956,CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome,3356,"OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).","Is the triple ""CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome"" supported by the sentence: ""OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).""?",False, -10437081,CHORIONIC GONADOTROPIN related to hypogonadism,3357,[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].,"Is the triple ""CHORIONIC GONADOTROPIN related to hypogonadism"" supported by the sentence: ""[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].""?",False, -10427260,CHORIONIC GONADOTROPIN related to infertility disorder,3358,[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].,"Is the triple ""CHORIONIC GONADOTROPIN related to infertility disorder"" supported by the sentence: ""[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].""?",False, -25953720,CHORIONIC GONADOTROPIN causes infertility disorder,3359,[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].,"Is the triple ""CHORIONIC GONADOTROPIN causes infertility disorder"" supported by the sentence: ""[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].""?",False, -12680602,CHORIONIC GONADOTROPIN causes Pregnancy,3360,Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.,"Is the triple ""CHORIONIC GONADOTROPIN causes Pregnancy"" supported by the sentence: ""Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.""?",False, -19382665,CHORIONIC GONADOTROPIN affects Pregnancy,3361,"Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.","Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.""?",False, -10661395,CHORIONIC GONADOTROPIN affects Pregnancy,3362,Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.,"Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.""?",False, -11878666,CHORIONIC GONADOTROPIN produces Pregnancy,3363,Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.,"Is the triple ""CHORIONIC GONADOTROPIN produces Pregnancy"" supported by the sentence: ""Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.""?",False, -19257969,Triclosan causes allergic disease,3364,Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.,"Is the triple ""Triclosan causes allergic disease"" supported by the sentence: ""Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.""?",False, -17886883,Triclosan affects gingivitis,3365,A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.,"Is the triple ""Triclosan affects gingivitis"" supported by the sentence: ""A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.""?",False, -9651026,Triclosan disrupts gingivitis,3366,"It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.","Is the triple ""Triclosan disrupts gingivitis"" supported by the sentence: ""It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.""?",False, -16053270,Triclosan prevents allergic disease,3367,"Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.","Is the triple ""Triclosan prevents allergic disease"" supported by the sentence: ""Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.""?",False, -20585436,Povidone iodine affects stomatitis,3368,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Povidone iodine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, -22182083,Povidone iodine prevents Infection,3369,"Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.","Is the triple ""Povidone iodine prevents Infection"" supported by the sentence: ""Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.""?",False, -22061199,Povidone iodine prevents dental caries,3370,"OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.","Is the triple ""Povidone iodine prevents dental caries"" supported by the sentence: ""OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.""?",False, -20053240,Povidone iodine prevents keratitis,3371,"The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.","Is the triple ""Povidone iodine prevents keratitis"" supported by the sentence: ""The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.""?",False, -25268747,Vinblastine related to acute myeloid leukemia,3372,Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.,"Is the triple ""Vinblastine related to acute myeloid leukemia"" supported by the sentence: ""Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.""?",False, -24601120,Vinblastine related to leukemia,3373,Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.,"Is the triple ""Vinblastine related to leukemia"" supported by the sentence: ""Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.""?",False, -17518639,Vinblastine related to testicular cancer,3374,"Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.","Is the triple ""Vinblastine related to testicular cancer"" supported by the sentence: ""Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.""?",False, -11295996,Vinblastine related to melanoma,3375,"The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.","Is the triple ""Vinblastine related to melanoma"" supported by the sentence: ""The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.""?",False, -10629211,Vinblastine related to castration-resistant prostate carcinoma,3376,CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.,"Is the triple ""Vinblastine related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.""?",False, -9405598,Vinblastine related to glioma,3377,The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.,"Is the triple ""Vinblastine related to glioma"" supported by the sentence: ""The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.""?",False, -8887641,Vinblastine related to neoplasm,3378,"Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.","Is the triple ""Vinblastine related to neoplasm"" supported by the sentence: ""Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.""?",False, -8831546,Vinblastine related to renal cell carcinoma,3379,Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.,"Is the triple ""Vinblastine related to renal cell carcinoma"" supported by the sentence: ""Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.""?",False, -8248825,Vinblastine related to lymphoma,3380,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Vinblastine related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, -8201846,Vinblastine related to Langerhans cell histiocytosis,3381,[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].,"Is the triple ""Vinblastine related to Langerhans cell histiocytosis"" supported by the sentence: ""[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].""?",False, -7111310,Vinblastine related to Hodgkins lymphoma,3382,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Vinblastine related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, -22913920,Vinblastine causes neoplasm,3383,"Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.","Is the triple ""Vinblastine causes neoplasm"" supported by the sentence: ""Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.""?",False, -14498052,Vinblastine affects Langerhans cell histiocytosis,3384,"Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.","Is the triple ""Vinblastine affects Langerhans cell histiocytosis"" supported by the sentence: ""Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.""?",False, -12889760,Vinblastine affects renal cell carcinoma,3385,"In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.","Is the triple ""Vinblastine affects renal cell carcinoma"" supported by the sentence: ""In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.""?",False, -11723511,Vinblastine affects neoplasm,3386,"By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.","Is the triple ""Vinblastine affects neoplasm"" supported by the sentence: ""By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.""?",False, -19032862,Vinblastine disrupts neoplasm,3387,We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.,"Is the triple ""Vinblastine disrupts neoplasm"" supported by the sentence: ""We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.""?",False, -26195658,Desacetylvinblastine amide related to lymphoma,3388,Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.,"Is the triple ""Desacetylvinblastine amide related to lymphoma"" supported by the sentence: ""Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.""?",False, -26116904,Desacetylvinblastine amide related to acute lymphoblastic leukemia,3389,"Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.","Is the triple ""Desacetylvinblastine amide related to acute lymphoblastic leukemia"" supported by the sentence: ""Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.""?",False, -25980030,Desacetylvinblastine amide related to small cell lung carcinoma,3390,"Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.","Is the triple ""Desacetylvinblastine amide related to small cell lung carcinoma"" supported by the sentence: ""Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.""?",False, -26313629,Desacetylvinblastine amide affects neoplasm,3391,Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).,"Is the triple ""Desacetylvinblastine amide affects neoplasm"" supported by the sentence: ""Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).""?",False, -26201212,Desacetylvinblastine amide affects acute lymphoblastic leukemia,3392,A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.,"Is the triple ""Desacetylvinblastine amide affects acute lymphoblastic leukemia"" supported by the sentence: ""A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.""?",False, -26302410,Desacetylvinblastine amide prevents neoplasm,3393,"No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.","Is the triple ""Desacetylvinblastine amide prevents neoplasm"" supported by the sentence: ""No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.""?",False, -25951740,Diazoxide causes hyperinsulinism,3394,"[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].","Is the triple ""Diazoxide causes hyperinsulinism"" supported by the sentence: ""[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].""?",False, -17059197,Diazoxide causes hypoglycemia,3395,CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.,"Is the triple ""Diazoxide causes hypoglycemia"" supported by the sentence: ""CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.""?",False, -25817473,Diazoxide affects hypertensive disorder,3396,The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.,"Is the triple ""Diazoxide affects hypertensive disorder"" supported by the sentence: ""The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.""?",False, -20202762,Diazoxide affects obesity disorder,3397,"Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.","Is the triple ""Diazoxide affects obesity disorder"" supported by the sentence: ""Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.""?",False, -11393233,Diazoxide affects hyperinsulinism,3398,Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).,"Is the triple ""Diazoxide affects hyperinsulinism"" supported by the sentence: ""Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).""?",False, -8184004,Diazoxide affects hypoglycemia,3399,"An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.","Is the triple ""Diazoxide affects hypoglycemia"" supported by the sentence: ""An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.""?",False, -9572369,Diazoxide disrupts hyperinsulinism,3400,"CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.","Is the triple ""Diazoxide disrupts hyperinsulinism"" supported by the sentence: ""CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.""?",False, -26286810,Diazoxide prevents hypoglycemia,3401,Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.,"Is the triple ""Diazoxide prevents hypoglycemia"" supported by the sentence: ""Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.""?",False, -22404640,Diazoxide prevents hypertensive disorder,3402,Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.,"Is the triple ""Diazoxide prevents hypertensive disorder"" supported by the sentence: ""Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.""?",False, -19200973,Diazoxide prevents obesity disorder,3403,OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.,"Is the triple ""Diazoxide prevents obesity disorder"" supported by the sentence: ""OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.""?",False, -16737667,Diazoxide predisposes hypoglycemia,3404,Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.,"Is the triple ""Diazoxide predisposes hypoglycemia"" supported by the sentence: ""Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.""?",False, -14267417,Pantoprazole affects gastroesophageal reflux disease,3405,Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).,"Is the triple ""Pantoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).""?",False, -12160514,Pantoprazole prevents active peptic ulcer disease,3406,"Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.","Is the triple ""Pantoprazole prevents active peptic ulcer disease"" supported by the sentence: ""Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.""?",False, -8423273,Pantoprazole prevents peptic ulcer disease,3407,"Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.","Is the triple ""Pantoprazole prevents peptic ulcer disease"" supported by the sentence: ""Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.""?",False, -7509578,Pantoprazole prevents ulcer disease,3408,"In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.","Is the triple ""Pantoprazole prevents ulcer disease"" supported by the sentence: ""In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.""?",False, -21088628,Pantoprazole predisposes active peptic ulcer disease,3409,"Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.","Is the triple ""Pantoprazole predisposes active peptic ulcer disease"" supported by the sentence: ""Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.""?",False, -20047688,Lansoprazole causes gastric ulcer,3410,"AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.","Is the triple ""Lansoprazole causes gastric ulcer"" supported by the sentence: ""AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.""?",False, -26544602,Lansoprazole affects peptic ulcer disease,3411,Effect of lansoprazole on peptic ulcers.,"Is the triple ""Lansoprazole affects peptic ulcer disease"" supported by the sentence: ""Effect of lansoprazole on peptic ulcers.""?",False, -11547923,Lansoprazole affects gastroesophageal reflux disease,3412,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Lansoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, -10008124,Lansoprazole affects peptic esophagitis,3413,"When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.","Is the triple ""Lansoprazole affects peptic esophagitis"" supported by the sentence: ""When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.""?",False, -7314434,Lansoprazole affects Helicobacter pylori infectious disease,3414,"Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.","Is the triple ""Lansoprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.""?",False, -9466998,Lansoprazole disrupts gastroesophageal reflux disease,3415,"In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).","Is the triple ""Lansoprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).""?",False, -20033093,Lansoprazole prevents peptic ulcer disease,3416,"CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.","Is the triple ""Lansoprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.""?",False, -15339719,Lansoprazole prevents duodenal ulcer,3417,"The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.","Is the triple ""Lansoprazole prevents duodenal ulcer"" supported by the sentence: ""The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.""?",False, -9335785,Lansoprazole prevents gastric ulcer,3418,"CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.","Is the triple ""Lansoprazole prevents gastric ulcer"" supported by the sentence: ""CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.""?",False, -8183428,Lansoprazole prevents gastroesophageal reflux disease,3419,"In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.","Is the triple ""Lansoprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.""?",False, -27664803,Lansoprazole exacerbates gastritis,3420,RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.,"Is the triple ""Lansoprazole exacerbates gastritis"" supported by the sentence: ""RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.""?",False, -10008126,Lansoprazole predisposes gastroesophageal reflux disease,3421,AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.,"Is the triple ""Lansoprazole predisposes gastroesophageal reflux disease"" supported by the sentence: ""AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.""?",False, -10345128,Omeprazole subclass of Omeprazole sulfone,3422,"The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.","Is the triple ""Omeprazole subclass of Omeprazole sulfone"" supported by the sentence: ""The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.""?",False, -8512321,Omeprazole subclass of Hydroxyomeprazole,3423,"The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.","Is the triple ""Omeprazole subclass of Hydroxyomeprazole"" supported by the sentence: ""The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.""?",False, -27115212,Omeprazole related to Omeprazole sulfone,3424,"Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.","Is the triple ""Omeprazole related to Omeprazole sulfone"" supported by the sentence: ""Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.""?",False, -12365583,Omeprazole related to gastric ulcer,3425,Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?,"Is the triple ""Omeprazole related to gastric ulcer"" supported by the sentence: ""Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?""?",False, -7744216,Omeprazole related to Hydroxyomeprazole,3426,"Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.","Is the triple ""Omeprazole related to Hydroxyomeprazole"" supported by the sentence: ""Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.""?",False, -26722672,Omeprazole physically interacts with Omeprazole sulfone,3427,"The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.","Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.""?",False, -9932953,Omeprazole physically interacts with Hydroxyomeprazole,3428,"Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).","Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).""?",False, -22198908,Omeprazole physically interacts with Omeprazole sulfone,3429,Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.,"Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.""?",False, -13085286,Omeprazole physically interacts with Hydroxyomeprazole,3430,The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.,"Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.""?",False, -27703677,Omeprazole causes anemia,3431,"Pyrexia, anaemia and acute renal failure secondary to omeprazole.","Is the triple ""Omeprazole causes anemia"" supported by the sentence: ""Pyrexia, anaemia and acute renal failure secondary to omeprazole.""?",False, -27298440,Omeprazole causes Hemorrhage,3432,"Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.","Is the triple ""Omeprazole causes Hemorrhage"" supported by the sentence: ""Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.""?",False, -24514538,Omeprazole causes peptic ulcer disease,3433,Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.,"Is the triple ""Omeprazole causes peptic ulcer disease"" supported by the sentence: ""Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.""?",False, -19641302,Omeprazole causes gastroesophageal reflux disease,3434,"The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.","Is the triple ""Omeprazole causes gastroesophageal reflux disease"" supported by the sentence: ""The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.""?",False, -15956000,Omeprazole causes esophagitis,3435,"Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.","Is the triple ""Omeprazole causes esophagitis"" supported by the sentence: ""Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.""?",False, -12187782,Omeprazole causes ulcer disease,3436,"Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.","Is the triple ""Omeprazole causes ulcer disease"" supported by the sentence: ""Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.""?",False, -11135889,Omeprazole causes injury,3437,"DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.","Is the triple ""Omeprazole causes injury"" supported by the sentence: ""DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.""?",False, -10813876,Omeprazole causes Cough,3438,Omeprazole-induced intractable cough.,"Is the triple ""Omeprazole causes Cough"" supported by the sentence: ""Omeprazole-induced intractable cough.""?",False, -8871402,Omeprazole causes gastric ulcer,3439,"Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.","Is the triple ""Omeprazole causes gastric ulcer"" supported by the sentence: ""Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.""?",False, -7272148,Omeprazole causes duodenal ulcer,3440,"Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.","Is the triple ""Omeprazole causes duodenal ulcer"" supported by the sentence: ""Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.""?",False, -27758339,Omeprazole affects Zollinger-Ellison syndrome,3441,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects Zollinger-Ellison syndrome"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, -27758338,Omeprazole affects peptic ulcer disease,3442,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, -27758337,Omeprazole affects peptic esophagitis,3443,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, -27733079,Omeprazole affects peptic esophagitis,3444,The effect of treating reflux oesophagitis with omeprazole on quality of life.,"Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""The effect of treating reflux oesophagitis with omeprazole on quality of life.""?",False, -27346919,Omeprazole affects peptic ulcer disease,3445,[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].,"Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].""?",False, -22440533,Omeprazole affects anemia,3446,Prolonged use of omeprazole may involve in inducing anemia.,"Is the triple ""Omeprazole affects anemia"" supported by the sentence: ""Prolonged use of omeprazole may involve in inducing anemia.""?",False, -18634760,Omeprazole affects Pain,3447,"Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.","Is the triple ""Omeprazole affects Pain"" supported by the sentence: ""Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.""?",False, -17967745,Omeprazole affects injury,3448,Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.,"Is the triple ""Omeprazole affects injury"" supported by the sentence: ""Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.""?",False, -12114858,Omeprazole affects ulcer disease,3449,"Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.""?",False, -11576921,Omeprazole affects Hydroxyomeprazole,3450,CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.""?",False, -10321262,Omeprazole affects duodenal ulcer,3451,"46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.","Is the triple ""Omeprazole affects duodenal ulcer"" supported by the sentence: ""46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.""?",False, -9976497,Omeprazole affects gastric ulcer,3452,A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.,"Is the triple ""Omeprazole affects gastric ulcer"" supported by the sentence: ""A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.""?",False, -8694897,Omeprazole affects Helicobacter pylori infectious disease,3453,"The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.","Is the triple ""Omeprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.""?",False, -8349380,Omeprazole affects Hemorrhage,3454,"CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.","Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.""?",False, -8349375,Omeprazole affects Hemorrhage,3455,Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, -7653505,Omeprazole affects gastroesophageal reflux disease,3456,The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.,"Is the triple ""Omeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.""?",False, -7572363,Omeprazole affects ulcer disease,3457,"Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".""?",False, -14345083,Omeprazole affects Hydroxyomeprazole,3458,The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.""?",False, -26726289,Omeprazole disrupts gastroesophageal reflux disease,3459,"A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.","Is the triple ""Omeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.""?",False, -26000029,Omeprazole disrupts Zollinger-Ellison syndrome,3460,Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.,"Is the triple ""Omeprazole disrupts Zollinger-Ellison syndrome"" supported by the sentence: ""Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.""?",False, -20129793,Omeprazole disrupts Barrett esophagus,3461,"Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.","Is the triple ""Omeprazole disrupts Barrett esophagus"" supported by the sentence: ""Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.""?",False, -19299462,Omeprazole disrupts active peptic ulcer disease,3462,"The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.","Is the triple ""Omeprazole disrupts active peptic ulcer disease"" supported by the sentence: ""The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.""?",False, -15524012,Omeprazole disrupts peptic ulcer disease,3463,Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.,"Is the triple ""Omeprazole disrupts peptic ulcer disease"" supported by the sentence: ""Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.""?",False, -13078646,Omeprazole disrupts ulcer disease,3464,"The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.","Is the triple ""Omeprazole disrupts ulcer disease"" supported by the sentence: ""The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.""?",False, -10891179,Omeprazole disrupts gastric ulcer,3465,"POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.","Is the triple ""Omeprazole disrupts gastric ulcer"" supported by the sentence: ""POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.""?",False, -10776897,Omeprazole disrupts duodenal ulcer,3466,"(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.","Is the triple ""Omeprazole disrupts duodenal ulcer"" supported by the sentence: ""(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.""?",False, -8884340,Omeprazole disrupts esophagitis,3467,"The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).","Is the triple ""Omeprazole disrupts esophagitis"" supported by the sentence: ""The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).""?",False, -27690262,Omeprazole prevents Helicobacter pylori infectious disease,3468,"To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.","Is the triple ""Omeprazole prevents Helicobacter pylori infectious disease"" supported by the sentence: ""To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.""?",False, -27025148,Omeprazole prevents Cough,3469,"Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.","Is the triple ""Omeprazole prevents Cough"" supported by the sentence: ""Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.""?",False, -26715213,Omeprazole prevents Pain,3470,Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.,"Is the triple ""Omeprazole prevents Pain"" supported by the sentence: ""Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.""?",False, -16929638,Omeprazole prevents esophagitis,3471,"Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.","Is the triple ""Omeprazole prevents esophagitis"" supported by the sentence: ""Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.""?",False, -15601042,Omeprazole prevents active peptic ulcer disease,3472,Omeprazole even can decrease gastro-intestinal bleeding in those patients.,"Is the triple ""Omeprazole prevents active peptic ulcer disease"" supported by the sentence: ""Omeprazole even can decrease gastro-intestinal bleeding in those patients.""?",False, -9292674,Omeprazole prevents peptic ulcer disease,3473,"CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.","Is the triple ""Omeprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.""?",False, -8884338,Omeprazole prevents peptic esophagitis,3474,IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.,"Is the triple ""Omeprazole prevents peptic esophagitis"" supported by the sentence: ""IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.""?",False, -8341772,Omeprazole prevents duodenal ulcer,3475,The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].,"Is the triple ""Omeprazole prevents duodenal ulcer"" supported by the sentence: ""The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].""?",False, -8169375,Omeprazole prevents injury,3476,"The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).","Is the triple ""Omeprazole prevents injury"" supported by the sentence: ""The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).""?",False, -7646984,Omeprazole prevents gastric ulcer,3477,Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.,"Is the triple ""Omeprazole prevents gastric ulcer"" supported by the sentence: ""Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.""?",False, -7653510,Omeprazole prevents gastroesophageal reflux disease,3478,"CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.","Is the triple ""Omeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.""?",False, -7332307,Omeprazole prevents ulcer disease,3479,Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.,"Is the triple ""Omeprazole prevents ulcer disease"" supported by the sentence: ""Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.""?",False, -24752030,Omeprazole predisposes type 2 diabetes mellitus,3480,"Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.","Is the triple ""Omeprazole predisposes type 2 diabetes mellitus"" supported by the sentence: ""Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.""?",False, -21309680,Omeprazole predisposes melanoma,3481,"The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.","Is the triple ""Omeprazole predisposes melanoma"" supported by the sentence: ""The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.""?",False, -20838741,Omeprazole predisposes Barrett esophagus,3482,"Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.","Is the triple ""Omeprazole predisposes Barrett esophagus"" supported by the sentence: ""Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.""?",False, -12649375,Rabeprazole affects infectious disease,3483,"METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).","Is the triple ""Rabeprazole affects infectious disease"" supported by the sentence: ""METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).""?",False, -11547924,Rabeprazole affects gastroesophageal reflux disease,3484,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Rabeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, -15461842,Rabeprazole disrupts gastroesophageal reflux disease,3485,CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.,"Is the triple ""Rabeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.""?",False, -16244495,Rabeprazole prevents peptic ulcer disease,3486,"We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.","Is the triple ""Rabeprazole prevents peptic ulcer disease"" supported by the sentence: ""We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.""?",False, -15354267,Rabeprazole prevents active peptic ulcer disease,3487,The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.,"Is the triple ""Rabeprazole prevents active peptic ulcer disease"" supported by the sentence: ""The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.""?",False, -8397732,Rabeprazole prevents gastroesophageal reflux disease,3488,RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).,"Is the triple ""Rabeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).""?",False, -23526790,Esomeprazole causes active peptic ulcer disease,3489,"Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.","Is the triple ""Esomeprazole causes active peptic ulcer disease"" supported by the sentence: ""Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.""?",False, -20333475,Esomeprazole causes preeclampsia,3490,We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.,"Is the triple ""Esomeprazole causes preeclampsia"" supported by the sentence: ""We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.""?",False, -15271081,Esomeprazole causes gastric ulcer,3491,The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.,"Is the triple ""Esomeprazole causes gastric ulcer"" supported by the sentence: ""The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.""?",False, -22638872,Esomeprazole affects neoplasm,3492,"Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.","Is the triple ""Esomeprazole affects neoplasm"" supported by the sentence: ""Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.""?",False, -20180848,Esomeprazole affects preeclampsia,3493,Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.,"Is the triple ""Esomeprazole affects preeclampsia"" supported by the sentence: ""Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.""?",False, -19360632,Esomeprazole affects ulcer disease,3494,Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.,"Is the triple ""Esomeprazole affects ulcer disease"" supported by the sentence: ""Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.""?",False, -18357402,Esomeprazole affects dyspepsia,3495,"Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.","Is the triple ""Esomeprazole affects dyspepsia"" supported by the sentence: ""Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.""?",False, -14247859,Esomeprazole affects gastric ulcer,3496,"In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.","Is the triple ""Esomeprazole affects gastric ulcer"" supported by the sentence: ""In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.""?",False, -12902689,Esomeprazole affects Hemorrhage,3497,The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, -12902688,Esomeprazole affects Hemorrhage,3498,Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, -12527967,Esomeprazole affects gastroesophageal reflux disease,3499,CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.,"Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.""?",False, -12015567,Esomeprazole affects gastroesophageal reflux disease,3500,"This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.","Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.""?",False, -10805094,Esomeprazole disrupts gastroesophageal reflux disease,3501,"The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.","Is the triple ""Esomeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.""?",False, -15938697,Esomeprazole prevents gastric ulcer,3502,"Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.","Is the triple ""Esomeprazole prevents gastric ulcer"" supported by the sentence: ""Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.""?",False, -14015294,Esomeprazole prevents gastroesophageal reflux disease,3503,CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.,"Is the triple ""Esomeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.""?",False, -13576722,Esomeprazole prevents peptic ulcer disease,3504,Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.,"Is the triple ""Esomeprazole prevents peptic ulcer disease"" supported by the sentence: ""Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.""?",False, -12321750,Esomeprazole prevents ulcer disease,3505,"CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.","Is the triple ""Esomeprazole prevents ulcer disease"" supported by the sentence: ""CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.""?",False, -10396538,Roflumilast related to asthma,3506,Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.,"Is the triple ""Roflumilast related to asthma"" supported by the sentence: ""Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.""?",False, -21017284,Roflumilast causes chronic obstructive pulmonary disease,3507,"Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.","Is the triple ""Roflumilast causes chronic obstructive pulmonary disease"" supported by the sentence: ""Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.""?",False, -21116198,Roflumilast affects obesity disorder,3508,"Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.","Is the triple ""Roflumilast affects obesity disorder"" supported by the sentence: ""Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.""?",False, -12290110,Roflumilast affects chronic obstructive pulmonary disease,3509,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects chronic obstructive pulmonary disease"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, -12290109,Roflumilast affects asthma,3510,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects asthma"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, -22432515,Roflumilast disrupts schizophrenia,3511,"CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.","Is the triple ""Roflumilast disrupts schizophrenia"" supported by the sentence: ""CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.""?",False, -24502817,Roflumilast prevents obesity disorder,3512,"RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.","Is the triple ""Roflumilast prevents obesity disorder"" supported by the sentence: ""RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.""?",False, -17763098,Roflumilast prevents diabetic kidney disease,3513,Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.,"Is the triple ""Roflumilast prevents diabetic kidney disease"" supported by the sentence: ""Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.""?",False, -15955656,Roflumilast prevents chronic obstructive pulmonary disease,3514,"Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.","Is the triple ""Roflumilast prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.""?",False, -8310806,Meperidine causes Pain,3515,OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.,"Is the triple ""Meperidine causes Pain"" supported by the sentence: ""OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.""?",False, -26434893,Meperidine affects Pain,3516,The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.,"Is the triple ""Meperidine affects Pain"" supported by the sentence: ""The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.""?",False, -18658715,Meperidine affects Pain,3517,"Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.","Is the triple ""Meperidine affects Pain"" supported by the sentence: ""Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.""?",False, -8345324,Meperidine prevents Pain,3518,The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.,"Is the triple ""Meperidine prevents Pain"" supported by the sentence: ""The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.""?",False, -21672389,Ketobemidone affects Pain,3519,"Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.","Is the triple ""Ketobemidone affects Pain"" supported by the sentence: ""Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.""?",False, -11850764,Travoprost related to ocular hypertension,3520,"CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.","Is the triple ""Travoprost related to ocular hypertension"" supported by the sentence: ""CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.""?",False, -12116829,Travoprost physically interacts with prostanoid FP receptor,3521,"PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.","Is the triple ""Travoprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.""?",False, -18294152,Travoprost affects ocular hypertension,3522,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects ocular hypertension"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, -18294151,Travoprost affects glaucoma,3523,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects glaucoma"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, -10166996,Travoprost prevents ocular hypertension,3524,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents ocular hypertension"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, -10166995,Travoprost prevents open-angle glaucoma,3525,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents open-angle glaucoma"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, -17904574,Tafluprost related to glaucoma,3526,Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.,"Is the triple ""Tafluprost related to glaucoma"" supported by the sentence: ""Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.""?",False, -15304153,Tafluprost related to ocular hypertension,3527,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to ocular hypertension"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, -15304152,Tafluprost related to open-angle glaucoma,3528,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to open-angle glaucoma"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, -14941475,Tafluprost physically interacts with prostanoid FP receptor,3529,Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.,"Is the triple ""Tafluprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.""?",False, -14941474,Tafluprost disrupts ocular hypertension,3530,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts ocular hypertension"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, -14941473,Tafluprost disrupts open-angle glaucoma,3531,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts open-angle glaucoma"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, -14231277,Ramelteon affects insomnia,3532,"Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.","Is the triple ""Ramelteon affects insomnia"" supported by the sentence: ""Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.""?",False, -21718213,Ramelteon prevents sleep-wake disorder,3533,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Ramelteon prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, -22873470,Melatonin related to acute kidney failure,3534,"Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.","Is the triple ""Melatonin related to acute kidney failure"" supported by the sentence: ""Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.""?",False, -22002909,Melatonin related to metabolic disease,3535,"Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.","Is the triple ""Melatonin related to metabolic disease"" supported by the sentence: ""Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.""?",False, -21777340,Melatonin related to Cognitive impairment,3536,"Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.","Is the triple ""Melatonin related to Cognitive impairment"" supported by the sentence: ""Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.""?",False, -18920431,Melatonin related to burn,3537,"CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.","Is the triple ""Melatonin related to burn"" supported by the sentence: ""CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.""?",False, -18846352,Melatonin related to skin disorder,3538,And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.,"Is the triple ""Melatonin related to skin disorder"" supported by the sentence: ""And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.""?",False, -18613354,Melatonin related to Neonatal sepsis,3539,Use of melatonin as an adjuvant therapy in neonatal sepsis.,"Is the triple ""Melatonin related to Neonatal sepsis"" supported by the sentence: ""Use of melatonin as an adjuvant therapy in neonatal sepsis.""?",False, -18189253,Melatonin related to necrotizing enterocolitis,3540,"This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.","Is the triple ""Melatonin related to necrotizing enterocolitis"" supported by the sentence: ""This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.""?",False, -17471678,"Melatonin related to dermatitis, atopic",3541,"To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.","Is the triple ""Melatonin related to dermatitis, atopic"" supported by the sentence: ""To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.""?",False, -17103445,Melatonin related to obstructive sleep apnea syndrome,3542,Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?,"Is the triple ""Melatonin related to obstructive sleep apnea syndrome"" supported by the sentence: ""Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?""?",False, -16423098,Melatonin related to periodontitis,3543,Previous studies reported decreased salivary and serum melatonin levels in periodontitis.,"Is the triple ""Melatonin related to periodontitis"" supported by the sentence: ""Previous studies reported decreased salivary and serum melatonin levels in periodontitis.""?",False, -16022569,Melatonin related to metabolic syndrome X,3544,"In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.","Is the triple ""Melatonin related to metabolic syndrome X"" supported by the sentence: ""In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.""?",False, -15882605,Melatonin related to enuresis,3545,"Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.","Is the triple ""Melatonin related to enuresis"" supported by the sentence: ""Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.""?",False, -15709123,Melatonin related to fibromyalgia,3546,Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.,"Is the triple ""Melatonin related to fibromyalgia"" supported by the sentence: ""Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.""?",False, -15665905,"Melatonin related to attention deficit hyperactivity disorder, inattentive type",3547,These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.,"Is the triple ""Melatonin related to attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.""?",False, -14933527,Melatonin related to autism spectrum disorder,3548,"Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.","Is the triple ""Melatonin related to autism spectrum disorder"" supported by the sentence: ""Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.""?",False, -14875890,Melatonin related to pervasive developmental disorder,3549,"Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.","Is the triple ""Melatonin related to pervasive developmental disorder"" supported by the sentence: ""Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.""?",False, -14786958,Melatonin related to gastroesophageal reflux disease,3550,The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.,"Is the triple ""Melatonin related to gastroesophageal reflux disease"" supported by the sentence: ""The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.""?",False, -13857052,Melatonin related to ulcerative colitis,3551,In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.,"Is the triple ""Melatonin related to ulcerative colitis"" supported by the sentence: ""In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.""?",False, -13491215,Melatonin related to diabetes mellitus,3552,(v) Melatonin influences diabetes and associated metabolic disturbances.,"Is the triple ""Melatonin related to diabetes mellitus"" supported by the sentence: ""(v) Melatonin influences diabetes and associated metabolic disturbances.""?",False, -13407170,Melatonin related to periodontal disorder,3553,BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.,"Is the triple ""Melatonin related to periodontal disorder"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.""?",False, -13365823,Melatonin related to tooth disorder,3554,"Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.","Is the triple ""Melatonin related to tooth disorder"" supported by the sentence: ""Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.""?",False, -12843346,Melatonin related to melanoma,3555,"Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.","Is the triple ""Melatonin related to melanoma"" supported by the sentence: ""Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.""?",False, -12132104,Melatonin related to irritable bowel syndrome,3556,AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).,"Is the triple ""Melatonin related to irritable bowel syndrome"" supported by the sentence: ""AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).""?",False, -11584899,Melatonin related to brain ischemia,3557,"Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.","Is the triple ""Melatonin related to brain ischemia"" supported by the sentence: ""Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.""?",False, -11533403,Melatonin related to hypertensive disorder,3558,"Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.","Is the triple ""Melatonin related to hypertensive disorder"" supported by the sentence: ""Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.""?",False, -11319171,Melatonin related to Pain,3559,These results suggest a proalgesic role of endogenous melatonin in tonic pain.,"Is the triple ""Melatonin related to Pain"" supported by the sentence: ""These results suggest a proalgesic role of endogenous melatonin in tonic pain.""?",False, -11137637,Melatonin related to essential hypertension,3560,"OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.","Is the triple ""Melatonin related to essential hypertension"" supported by the sentence: ""OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.""?",False, -10685850,Melatonin related to major depressive disorder,3561,"Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.","Is the triple ""Melatonin related to major depressive disorder"" supported by the sentence: ""Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.""?",False, -10528037,Melatonin related to multiple sclerosis,3562,"Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.","Is the triple ""Melatonin related to multiple sclerosis"" supported by the sentence: ""Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.""?",False, -10477010,Melatonin related to non-small cell lung carcinoma,3563,"On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.","Is the triple ""Melatonin related to non-small cell lung carcinoma"" supported by the sentence: ""On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.""?",False, -10371972,Melatonin related to delirium,3564,"Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.","Is the triple ""Melatonin related to delirium"" supported by the sentence: ""Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.""?",False, -10204563,Melatonin related to depressive disorder,3565,"Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.","Is the triple ""Melatonin related to depressive disorder"" supported by the sentence: ""Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.""?",False, -9947492,Melatonin related to myocardial infarction,3566,Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.,"Is the triple ""Melatonin related to myocardial infarction"" supported by the sentence: ""Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.""?",False, -9516882,Melatonin related to Parkinson disease,3567,Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.,"Is the triple ""Melatonin related to Parkinson disease"" supported by the sentence: ""Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.""?",False, -9086006,Melatonin related to ischemia reperfusion injury,3568,"Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.","Is the triple ""Melatonin related to ischemia reperfusion injury"" supported by the sentence: ""Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.""?",False, -9074687,Melatonin related to Sepsis,3569,"These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.","Is the triple ""Melatonin related to Sepsis"" supported by the sentence: ""These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.""?",False, -8867365,Melatonin related to schizophrenia,3570,"CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.","Is the triple ""Melatonin related to schizophrenia"" supported by the sentence: ""CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.""?",False, -8780387,Melatonin related to insomnia,3571,"The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.","Is the triple ""Melatonin related to insomnia"" supported by the sentence: ""The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.""?",False, -8686098,Melatonin related to dementia,3572,OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.,"Is the triple ""Melatonin related to dementia"" supported by the sentence: ""OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.""?",False, -8623112,Melatonin related to migraine disorder,3573,"This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.","Is the triple ""Melatonin related to migraine disorder"" supported by the sentence: ""This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.""?",False, -7795396,Melatonin related to injury,3574,"Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.","Is the triple ""Melatonin related to injury"" supported by the sentence: ""Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.""?",False, -7482169,Melatonin related to neoplasm,3575,Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.,"Is the triple ""Melatonin related to neoplasm"" supported by the sentence: ""Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.""?",False, -7440685,Melatonin related to Fatigue,3576,"Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.","Is the triple ""Melatonin related to Fatigue"" supported by the sentence: ""Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.""?",False, -7185935,Melatonin related to epilepsy,3577,Melatonin in epilepsy: first results of replacement therapy and first clinical results.,"Is the triple ""Melatonin related to epilepsy"" supported by the sentence: ""Melatonin in epilepsy: first results of replacement therapy and first clinical results.""?",False, -7185921,Melatonin related to sleep-wake disorder,3578,Melatonin in circadian sleep disorders in the blind.,"Is the triple ""Melatonin related to sleep-wake disorder"" supported by the sentence: ""Melatonin in circadian sleep disorders in the blind.""?",False, -26987553,Melatonin causes Fatigue,3579,"Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.","Is the triple ""Melatonin causes Fatigue"" supported by the sentence: ""Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.""?",False, -24500836,Melatonin causes anxiety,3580,"Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.","Is the triple ""Melatonin causes anxiety"" supported by the sentence: ""Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.""?",False, -22662368,Melatonin causes dementia,3581,"A chronic melatonin deficiency, with loss of dreams, could cause dementia.","Is the triple ""Melatonin causes dementia"" supported by the sentence: ""A chronic melatonin deficiency, with loss of dreams, could cause dementia.""?",False, -21258564,Melatonin causes multiple sclerosis,3582,"A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.","Is the triple ""Melatonin causes multiple sclerosis"" supported by the sentence: ""A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.""?",False, -19886996,Melatonin causes Cognitive impairment,3583,"However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.","Is the triple ""Melatonin causes Cognitive impairment"" supported by the sentence: ""However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.""?",False, -19573910,Melatonin causes periodontitis,3584,Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.,"Is the triple ""Melatonin causes periodontitis"" supported by the sentence: ""Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.""?",False, -17837306,Melatonin causes metabolic disease,3585,"This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.","Is the triple ""Melatonin causes metabolic disease"" supported by the sentence: ""This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.""?",False, -17714427,Melatonin causes myocardial infarction,3586,The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.,"Is the triple ""Melatonin causes myocardial infarction"" supported by the sentence: ""The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.""?",False, -16705153,Melatonin causes Sepsis,3587,Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.,"Is the triple ""Melatonin causes Sepsis"" supported by the sentence: ""Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.""?",False, -15644359,Melatonin causes gastroesophageal reflux disease,3588,Low levels of melatonin lead to gastroesophageal reflux disease (GERD).,"Is the triple ""Melatonin causes gastroesophageal reflux disease"" supported by the sentence: ""Low levels of melatonin lead to gastroesophageal reflux disease (GERD).""?",False, -14831403,Melatonin causes periodontal disorder,3589,"BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.","Is the triple ""Melatonin causes periodontal disorder"" supported by the sentence: ""BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.""?",False, -14171289,Melatonin causes Parkinson disease,3590,"Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.","Is the triple ""Melatonin causes Parkinson disease"" supported by the sentence: ""Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.""?",False, -14078373,Melatonin causes hypertensive disorder,3591,Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.,"Is the triple ""Melatonin causes hypertensive disorder"" supported by the sentence: ""Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.""?",False, -13896033,Melatonin causes breast neoplasm,3592,"Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.","Is the triple ""Melatonin causes breast neoplasm"" supported by the sentence: ""Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.""?",False, -13361926,Melatonin causes ischemia reperfusion injury,3593,The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.,"Is the triple ""Melatonin causes ischemia reperfusion injury"" supported by the sentence: ""The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.""?",False, -13039360,Melatonin causes epilepsy,3594,"In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.","Is the triple ""Melatonin causes epilepsy"" supported by the sentence: ""In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.""?",False, -12762592,Melatonin causes enuresis,3595,"CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.","Is the triple ""Melatonin causes enuresis"" supported by the sentence: ""CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.""?",False, -12275569,Melatonin causes diabetes mellitus,3596,"Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.","Is the triple ""Melatonin causes diabetes mellitus"" supported by the sentence: ""Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.""?",False, -12071557,Melatonin causes insomnia,3597,"Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.","Is the triple ""Melatonin causes insomnia"" supported by the sentence: ""Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.""?",False, -10432083,Melatonin causes migraine disorder,3598,"The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.","Is the triple ""Melatonin causes migraine disorder"" supported by the sentence: ""The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.""?",False, -10432067,Melatonin causes schizophrenia,3599,"I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.","Is the triple ""Melatonin causes schizophrenia"" supported by the sentence: ""I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.""?",False, -9114525,Melatonin causes neoplasm,3600,"Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.","Is the triple ""Melatonin causes neoplasm"" supported by the sentence: ""Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.""?",False, -8785660,Melatonin causes depressive disorder,3601,The melatonin-induced depression was followed by a slow recovery phase.,"Is the triple ""Melatonin causes depressive disorder"" supported by the sentence: ""The melatonin-induced depression was followed by a slow recovery phase.""?",False, -8291971,Melatonin causes injury,3602,"Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.","Is the triple ""Melatonin causes injury"" supported by the sentence: ""Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.""?",False, -25620630,Melatonin affects Fatigue,3603,"Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.""?",False, -25259613,Melatonin affects atrial fibrillation,3604,"Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.","Is the triple ""Melatonin affects atrial fibrillation"" supported by the sentence: ""Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.""?",False, -24144792,Melatonin affects myocardial infarction,3605,"RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.","Is the triple ""Melatonin affects myocardial infarction"" supported by the sentence: ""RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.""?",False, -24094187,Melatonin affects major depressive disorder,3606,"A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.","Is the triple ""Melatonin affects major depressive disorder"" supported by the sentence: ""A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.""?",False, -23101890,Melatonin affects periodontitis,3607,The Effect of Melatonin on Periodontitis.,"Is the triple ""Melatonin affects periodontitis"" supported by the sentence: ""The Effect of Melatonin on Periodontitis.""?",False, -22037016,Melatonin affects diabetes mellitus,3608,Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.,"Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.""?",False, -21523229,Melatonin affects anxiety,3609,The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.,"Is the triple ""Melatonin affects anxiety"" supported by the sentence: ""The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.""?",False, -21046382,Melatonin affects non-small cell lung carcinoma,3610,"Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.","Is the triple ""Melatonin affects non-small cell lung carcinoma"" supported by the sentence: ""Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.""?",False, -20888328,Melatonin affects autism spectrum disorder,3611,"In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.","Is the triple ""Melatonin affects autism spectrum disorder"" supported by the sentence: ""In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.""?",False, -18858036,Melatonin affects Cognitive impairment,3612,Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.,"Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.""?",False, -18703578,Melatonin affects Marchiafava-Bignami disease,3613,"The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.","Is the triple ""Melatonin affects Marchiafava-Bignami disease"" supported by the sentence: ""The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.""?",False, -18605461,Melatonin affects Neonatal sepsis,3614,CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.""?",False, -18605459,Melatonin affects Neonatal sepsis,3615,Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.""?",False, -18111864,Melatonin affects Hemorrhage,3616,Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.,"Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.""?",False, -17774103,Melatonin affects fibromyalgia,3617,"Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).","Is the triple ""Melatonin affects fibromyalgia"" supported by the sentence: ""Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).""?",False, -17471677,"Melatonin affects dermatitis, atopic",3618,Alterations of melatonin secretion in atopic eczema.,"Is the triple ""Melatonin affects dermatitis, atopic"" supported by the sentence: ""Alterations of melatonin secretion in atopic eczema.""?",False, -17402992,Melatonin affects Fatigue,3619,"Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.""?",False, -17199486,Melatonin affects Sepsis,3620,Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.,"Is the triple ""Melatonin affects Sepsis"" supported by the sentence: ""Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.""?",False, -17103446,Melatonin affects obstructive sleep apnea syndrome,3621,The data on the involvement of melatonin in OSAS are rare.,"Is the triple ""Melatonin affects obstructive sleep apnea syndrome"" supported by the sentence: ""The data on the involvement of melatonin in OSAS are rare.""?",False, -17112614,Melatonin affects ulcerative colitis,3622,Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.,"Is the triple ""Melatonin affects ulcerative colitis"" supported by the sentence: ""Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.""?",False, -16898660,Melatonin affects Cognitive impairment,3623,"Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.""?",False, -16300651,Melatonin affects depressive disorder,3624,"Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.""?",False, -16293202,Melatonin affects Hemorrhage,3625,"Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.","Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.""?",False, -16189615,Melatonin affects Cognitive impairment,3626,"The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.""?",False, -15390003,Melatonin affects delirium,3627,Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.,"Is the triple ""Melatonin affects delirium"" supported by the sentence: ""Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.""?",False, -14400565,Melatonin affects burn,3628,Effect of melatonin on burn-induced gastric mucosal injury in rats.,"Is the triple ""Melatonin affects burn"" supported by the sentence: ""Effect of melatonin on burn-induced gastric mucosal injury in rats.""?",False, -14333232,Melatonin affects schizophrenia,3629,"""Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.","Is the triple ""Melatonin affects schizophrenia"" supported by the sentence: """"Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.""?",False, -13430046,Melatonin affects epilepsy,3630,"Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.","Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.""?",False, -13158859,Melatonin affects tooth disorder,3631,"RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.","Is the triple ""Melatonin affects tooth disorder"" supported by the sentence: ""RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.""?",False, -12620684,Melatonin affects melanoma,3632,Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.,"Is the triple ""Melatonin affects melanoma"" supported by the sentence: ""Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.""?",False, -12473519,Melatonin affects Parkinson disease,3633,Melatonin secretion has been found to be altered in AD and PD.,"Is the triple ""Melatonin affects Parkinson disease"" supported by the sentence: ""Melatonin secretion has been found to be altered in AD and PD.""?",False, -11739216,Melatonin affects sleep-wake disorder,3634,"To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).","Is the triple ""Melatonin affects sleep-wake disorder"" supported by the sentence: ""To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).""?",False, -11451669,Melatonin affects depressive disorder,3635,"Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.""?",False, -10979770,Melatonin affects insomnia,3636,Potential action of melatonin in insomnia.,"Is the triple ""Melatonin affects insomnia"" supported by the sentence: ""Potential action of melatonin in insomnia.""?",False, -10516034,Melatonin affects Pain,3637,"An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.","Is the triple ""Melatonin affects Pain"" supported by the sentence: ""An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.""?",False, -10432086,Melatonin affects multiple sclerosis,3638,Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.,"Is the triple ""Melatonin affects multiple sclerosis"" supported by the sentence: ""Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.""?",False, -10047665,Melatonin affects hypertensive disorder,3639,Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.,"Is the triple ""Melatonin affects hypertensive disorder"" supported by the sentence: ""Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.""?",False, -9535418,Melatonin affects injury,3640,We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.,"Is the triple ""Melatonin affects injury"" supported by the sentence: ""We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.""?",False, -9364224,Melatonin affects Pain,3641,Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.,"Is the triple ""Melatonin affects Pain"" supported by the sentence: ""Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.""?",False, -9244581,Melatonin affects migraine disorder,3642,"The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.","Is the triple ""Melatonin affects migraine disorder"" supported by the sentence: ""The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.""?",False, -9153135,Melatonin affects diabetes mellitus,3643,"Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.","Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.""?",False, -9143737,Melatonin affects epilepsy,3644,Melatonin effect on seizures in children with severe neurologic deficit disorders.,"Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Melatonin effect on seizures in children with severe neurologic deficit disorders.""?",False, -9114510,Melatonin affects ischemia reperfusion injury,3645,This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.,"Is the triple ""Melatonin affects ischemia reperfusion injury"" supported by the sentence: ""This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.""?",False, -8993003,Melatonin affects neoplasm,3646,"However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.","Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.""?",False, -8720758,Melatonin affects breast neoplasm,3647,We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.,"Is the triple ""Melatonin affects breast neoplasm"" supported by the sentence: ""We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.""?",False, -8108047,Melatonin affects depressive disorder,3648,"Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.""?",False, -7564928,Melatonin affects neoplasm,3649,Melatonin also affects tumorigenesis and tumor development.,"Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""Melatonin also affects tumorigenesis and tumor development.""?",False, -7382212,Melatonin affects brain ischemia,3650,These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.,"Is the triple ""Melatonin affects brain ischemia"" supported by the sentence: ""These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.""?",False, -26765396,Melatonin produces epilepsy,3651,Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.,"Is the triple ""Melatonin produces epilepsy"" supported by the sentence: ""Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.""?",False, -22867260,Melatonin produces diabetes mellitus,3652,"Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.","Is the triple ""Melatonin produces diabetes mellitus"" supported by the sentence: ""Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.""?",False, -18240585,Melatonin produces ulcerative colitis,3653,METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.,"Is the triple ""Melatonin produces ulcerative colitis"" supported by the sentence: ""METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.""?",False, -17207380,Melatonin produces autism spectrum disorder,3654,"Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.","Is the triple ""Melatonin produces autism spectrum disorder"" supported by the sentence: ""Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.""?",False, -17051558,Melatonin produces depressive disorder,3655,These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.,"Is the triple ""Melatonin produces depressive disorder"" supported by the sentence: ""These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.""?",False, -16192357,Melatonin produces sleep-wake disorder,3656,"The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.","Is the triple ""Melatonin produces sleep-wake disorder"" supported by the sentence: ""The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.""?",False, -13817260,Melatonin produces Parkinson disease,3657,"Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.","Is the triple ""Melatonin produces Parkinson disease"" supported by the sentence: ""Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.""?",False, -11388402,Melatonin produces neoplasm,3658,"The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.","Is the triple ""Melatonin produces neoplasm"" supported by the sentence: ""The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.""?",False, -9153153,Melatonin produces hypertensive disorder,3659,"Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.","Is the triple ""Melatonin produces hypertensive disorder"" supported by the sentence: ""Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.""?",False, -8191029,Melatonin produces breast neoplasm,3660,"The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.","Is the triple ""Melatonin produces breast neoplasm"" supported by the sentence: ""The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.""?",False, -24623673,Melatonin disrupts atrial fibrillation,3661,Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).,"Is the triple ""Melatonin disrupts atrial fibrillation"" supported by the sentence: ""Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).""?",False, -24220852,Melatonin disrupts metabolic disease,3662,"Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.","Is the triple ""Melatonin disrupts metabolic disease"" supported by the sentence: ""Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.""?",False, -22817547,Melatonin disrupts anxiety,3663,"Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.","Is the triple ""Melatonin disrupts anxiety"" supported by the sentence: ""Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.""?",False, -20966258,Melatonin disrupts Cognitive impairment,3664,"Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.","Is the triple ""Melatonin disrupts Cognitive impairment"" supported by the sentence: ""Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.""?",False, -20623050,"Melatonin disrupts attention deficit hyperactivity disorder, inattentive type",3665,Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.,"Is the triple ""Melatonin disrupts attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.""?",False, -19958338,Melatonin disrupts multiple sclerosis,3666,Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.,"Is the triple ""Melatonin disrupts multiple sclerosis"" supported by the sentence: ""Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.""?",False, -18007482,Melatonin disrupts Sepsis,3667,"Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.","Is the triple ""Melatonin disrupts Sepsis"" supported by the sentence: ""Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.""?",False, -18002672,Melatonin disrupts Pain,3668,STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.,"Is the triple ""Melatonin disrupts Pain"" supported by the sentence: ""STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.""?",False, -16753621,Melatonin disrupts sleep-wake disorder,3669,"Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.","Is the triple ""Melatonin disrupts sleep-wake disorder"" supported by the sentence: ""Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.""?",False, -14914180,Melatonin disrupts melanoma,3670,"Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.","Is the triple ""Melatonin disrupts melanoma"" supported by the sentence: ""Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.""?",False, -14617999,"Melatonin disrupts dermatitis, atopic",3671,"Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.","Is the triple ""Melatonin disrupts dermatitis, atopic"" supported by the sentence: ""Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.""?",False, -13855513,Melatonin disrupts Hemorrhage,3672,"Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.","Is the triple ""Melatonin disrupts Hemorrhage"" supported by the sentence: ""Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.""?",False, -10721769,Melatonin disrupts depressive disorder,3673,Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.,"Is the triple ""Melatonin disrupts depressive disorder"" supported by the sentence: ""Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.""?",False, -10333555,Melatonin disrupts injury,3674,"Moreover, melatonin diminished iron-induced oxidative injury.","Is the triple ""Melatonin disrupts injury"" supported by the sentence: ""Moreover, melatonin diminished iron-induced oxidative injury.""?",False, -10294227,Melatonin disrupts breast neoplasm,3675,"During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.","Is the triple ""Melatonin disrupts breast neoplasm"" supported by the sentence: ""During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.""?",False, -10070181,Melatonin disrupts brain ischemia,3676,"Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.","Is the triple ""Melatonin disrupts brain ischemia"" supported by the sentence: ""Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.""?",False, -10008170,Melatonin disrupts Marchiafava-Bignami disease,3677,"Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.","Is the triple ""Melatonin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.""?",False, -8932328,Melatonin disrupts epilepsy,3678,"Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.","Is the triple ""Melatonin disrupts epilepsy"" supported by the sentence: ""Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.""?",False, -7916082,Melatonin disrupts ischemia reperfusion injury,3679,"Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.","Is the triple ""Melatonin disrupts ischemia reperfusion injury"" supported by the sentence: ""Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.""?",False, -7545973,Melatonin disrupts neoplasm,3680,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin disrupts neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, -24902716,Melatonin prevents stomatitis,3681,"MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).","Is the triple ""Melatonin prevents stomatitis"" supported by the sentence: ""MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).""?",False, -24687342,Melatonin prevents essential hypertension,3682,The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.,"Is the triple ""Melatonin prevents essential hypertension"" supported by the sentence: ""The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.""?",False, -24623674,Melatonin prevents atrial fibrillation,3683,"Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.","Is the triple ""Melatonin prevents atrial fibrillation"" supported by the sentence: ""Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.""?",False, -24368351,Melatonin prevents acute kidney failure,3684,"Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.","Is the triple ""Melatonin prevents acute kidney failure"" supported by the sentence: ""Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.""?",False, -23824121,Melatonin prevents dementia,3685,"While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.","Is the triple ""Melatonin prevents dementia"" supported by the sentence: ""While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.""?",False, -23122960,Melatonin prevents Cognitive impairment,3686,Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.,"Is the triple ""Melatonin prevents Cognitive impairment"" supported by the sentence: ""Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.""?",False, -22817548,Melatonin prevents anxiety,3687,"Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).","Is the triple ""Melatonin prevents anxiety"" supported by the sentence: ""Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).""?",False, -21718214,Melatonin prevents sleep-wake disorder,3688,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Melatonin prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, -20260777,Melatonin prevents Pain,3689,"In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).","Is the triple ""Melatonin prevents Pain"" supported by the sentence: ""In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).""?",False, -19640170,Melatonin prevents aortic aneurysm,3690,This study examined whether melatonin has protective or therapeutic effects against AAAs.,"Is the triple ""Melatonin prevents aortic aneurysm"" supported by the sentence: ""This study examined whether melatonin has protective or therapeutic effects against AAAs.""?",False, -18396849,Melatonin prevents Sepsis,3691,Previous studies have suggested that melatonin is protective during sepsis.,"Is the triple ""Melatonin prevents Sepsis"" supported by the sentence: ""Previous studies have suggested that melatonin is protective during sepsis.""?",False, -18141997,Melatonin prevents metabolic disease,3692,Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.,"Is the triple ""Melatonin prevents metabolic disease"" supported by the sentence: ""Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.""?",False, -16995162,Melatonin prevents metabolic syndrome X,3693,Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.,"Is the triple ""Melatonin prevents metabolic syndrome X"" supported by the sentence: ""Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.""?",False, -16549748,Melatonin prevents burn,3694,Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.,"Is the triple ""Melatonin prevents burn"" supported by the sentence: ""Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.""?",False, -16245777,Melatonin prevents schizophrenia,3695,"The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.","Is the triple ""Melatonin prevents schizophrenia"" supported by the sentence: ""The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.""?",False, -16232642,Melatonin prevents Marchiafava-Bignami disease,3696,"This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.","Is the triple ""Melatonin prevents Marchiafava-Bignami disease"" supported by the sentence: ""This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.""?",False, -15150085,Melatonin prevents depressive disorder,3697,"It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.","Is the triple ""Melatonin prevents depressive disorder"" supported by the sentence: ""It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.""?",False, -14373042,Melatonin prevents Parkinson disease,3698,"We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.","Is the triple ""Melatonin prevents Parkinson disease"" supported by the sentence: ""We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.""?",False, -11616466,Melatonin prevents autism spectrum disorder,3699,CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.,"Is the triple ""Melatonin prevents autism spectrum disorder"" supported by the sentence: ""CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.""?",False, -11366467,Melatonin prevents migraine disorder,3700,"Melatonin, 3 mg, is effective for migraine prevention.","Is the triple ""Melatonin prevents migraine disorder"" supported by the sentence: ""Melatonin, 3 mg, is effective for migraine prevention.""?",False, -11108260,Melatonin prevents hypertensive disorder,3701,We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.,"Is the triple ""Melatonin prevents hypertensive disorder"" supported by the sentence: ""We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.""?",False, -11061121,Melatonin prevents insomnia,3702,Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.,"Is the triple ""Melatonin prevents insomnia"" supported by the sentence: ""Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.""?",False, -10234923,Melatonin prevents breast neoplasm,3703,Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.,"Is the triple ""Melatonin prevents breast neoplasm"" supported by the sentence: ""Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.""?",False, -10127047,Melatonin prevents myocardial infarction,3704,Protective effect of melatonin on myocardial infarction.,"Is the triple ""Melatonin prevents myocardial infarction"" supported by the sentence: ""Protective effect of melatonin on myocardial infarction.""?",False, -9561452,Melatonin prevents diabetes mellitus,3705,Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.,"Is the triple ""Melatonin prevents diabetes mellitus"" supported by the sentence: ""Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.""?",False, -9346845,Melatonin prevents delirium,3706,Two cases are presented where melatonin was used to treat and prevent postoperative delirium.,"Is the triple ""Melatonin prevents delirium"" supported by the sentence: ""Two cases are presented where melatonin was used to treat and prevent postoperative delirium.""?",False, -9336280,Melatonin prevents brain ischemia,3707,"Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.","Is the triple ""Melatonin prevents brain ischemia"" supported by the sentence: ""Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.""?",False, -8678642,Melatonin prevents epilepsy,3708,"The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.","Is the triple ""Melatonin prevents epilepsy"" supported by the sentence: ""The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.""?",False, -8166782,Melatonin prevents ischemia reperfusion injury,3709,"In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.","Is the triple ""Melatonin prevents ischemia reperfusion injury"" supported by the sentence: ""In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.""?",False, -7622774,Melatonin prevents injury,3710,CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.,"Is the triple ""Melatonin prevents injury"" supported by the sentence: ""CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.""?",False, -7545974,Melatonin prevents neoplasm,3711,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin prevents neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, -19276524,Melatonin exacerbates diabetes mellitus,3712,"However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.","Is the triple ""Melatonin exacerbates diabetes mellitus"" supported by the sentence: ""However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.""?",False, -7980097,Melatonin exacerbates brain ischemia,3713,"Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.","Is the triple ""Melatonin exacerbates brain ischemia"" supported by the sentence: ""Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.""?",False, -27283551,Melatonin predisposes hypertensive disorder,3714,"Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.","Is the triple ""Melatonin predisposes hypertensive disorder"" supported by the sentence: ""Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.""?",False, -23266236,Melatonin predisposes epilepsy,3715,"CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.","Is the triple ""Melatonin predisposes epilepsy"" supported by the sentence: ""CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.""?",False, -21026194,Melatonin predisposes migraine disorder,3716,"CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.","Is the triple ""Melatonin predisposes migraine disorder"" supported by the sentence: ""CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.""?",False, -20835242,Melatonin predisposes metabolic syndrome X,3717,"Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.","Is the triple ""Melatonin predisposes metabolic syndrome X"" supported by the sentence: ""Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.""?",False, -20419573,Melatonin predisposes major depressive disorder,3718,Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.,"Is the triple ""Melatonin predisposes major depressive disorder"" supported by the sentence: ""Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.""?",False, -19382519,Melatonin predisposes periodontal disorder,3719,"With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.","Is the triple ""Melatonin predisposes periodontal disorder"" supported by the sentence: ""With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.""?",False, -18749948,Melatonin predisposes autism spectrum disorder,3720,"This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.","Is the triple ""Melatonin predisposes autism spectrum disorder"" supported by the sentence: ""This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.""?",False, -18605458,Melatonin predisposes Neonatal sepsis,3721,OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.,"Is the triple ""Melatonin predisposes Neonatal sepsis"" supported by the sentence: ""OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.""?",False, -18359560,Melatonin predisposes depressive disorder,3722,Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).,"Is the triple ""Melatonin predisposes depressive disorder"" supported by the sentence: ""Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).""?",False, -16852096,Melatonin predisposes diabetes mellitus,3723,Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.,"Is the triple ""Melatonin predisposes diabetes mellitus"" supported by the sentence: ""Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.""?",False, -15094135,Melatonin predisposes injury,3724,"The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.","Is the triple ""Melatonin predisposes injury"" supported by the sentence: ""The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.""?",False, -14875892,Melatonin predisposes pervasive developmental disorder,3725,A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.,"Is the triple ""Melatonin predisposes pervasive developmental disorder"" supported by the sentence: ""A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.""?",False, -11794031,Melatonin predisposes neoplasm,3726,"Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.","Is the triple ""Melatonin predisposes neoplasm"" supported by the sentence: ""Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.""?",False, -11643546,Melatonin predisposes dementia,3727,Melatonin relieves the neural oxidative burden that contributes to dementias.,"Is the triple ""Melatonin predisposes dementia"" supported by the sentence: ""Melatonin relieves the neural oxidative burden that contributes to dementias.""?",False, -10915746,Melatonin predisposes sleep-wake disorder,3728,"CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.","Is the triple ""Melatonin predisposes sleep-wake disorder"" supported by the sentence: ""CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.""?",False, -10114913,Melatonin predisposes myocardial infarction,3729,These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.,"Is the triple ""Melatonin predisposes myocardial infarction"" supported by the sentence: ""These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.""?",False, -12950718,RETEPLASE related to thrombotic disease,3730,Spotlight on reteplase in thrombotic occlusive disorders.,"Is the triple ""RETEPLASE related to thrombotic disease"" supported by the sentence: ""Spotlight on reteplase in thrombotic occlusive disorders.""?",False, -7082056,RETEPLASE related to stroke disorder,3731,"Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.","Is the triple ""RETEPLASE related to stroke disorder"" supported by the sentence: ""Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.""?",False, -12026281,UROKINASE related to stroke disorder,3732,Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.,"Is the triple ""UROKINASE related to stroke disorder"" supported by the sentence: ""Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.""?",False, -11808316,UROKINASE related to empyema,3733,"Intrapleural urokinase is an effective treatment, including in empyemas without loculation.","Is the triple ""UROKINASE related to empyema"" supported by the sentence: ""Intrapleural urokinase is an effective treatment, including in empyemas without loculation.""?",False, -9909017,UROKINASE related to pleural empyema,3734,Use of urokinase in childhood pleural empyema.,"Is the triple ""UROKINASE related to pleural empyema"" supported by the sentence: ""Use of urokinase in childhood pleural empyema.""?",False, -9695495,UROKINASE related to thrombotic disease,3735,Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.,"Is the triple ""UROKINASE related to thrombotic disease"" supported by the sentence: ""Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.""?",False, -7757067,UROKINASE related to pulmonary embolism,3736,CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.,"Is the triple ""UROKINASE related to pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.""?",False, -20949144,UROKINASE causes thrombotic disease,3737,"After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.","Is the triple ""UROKINASE causes thrombotic disease"" supported by the sentence: ""After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.""?",False, -7392657,UROKINASE causes pulmonary embolism,3738,"Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.","Is the triple ""UROKINASE causes pulmonary embolism"" supported by the sentence: ""Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.""?",False, -26135964,UROKINASE affects pulmonary embolism,3739,A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.,"Is the triple ""UROKINASE affects pulmonary embolism"" supported by the sentence: ""A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.""?",False, -25781305,UROKINASE affects thrombotic disease,3740,"Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.","Is the triple ""UROKINASE affects thrombotic disease"" supported by the sentence: ""Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.""?",False, -26885635,UROKINASE disrupts thrombotic disease,3741,"In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.","Is the triple ""UROKINASE disrupts thrombotic disease"" supported by the sentence: ""In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.""?",False, -11607211,UROKINASE prevents thrombotic disease,3742,"To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.","Is the triple ""UROKINASE prevents thrombotic disease"" supported by the sentence: ""To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.""?",False, -8505599,UROKINASE prevents pulmonary embolism,3743,"CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.","Is the triple ""UROKINASE prevents pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.""?",False, -26334889,UROKINASE predisposes pulmonary embolism,3744,"Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.","Is the triple ""UROKINASE predisposes pulmonary embolism"" supported by the sentence: ""Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.""?",False, -13797160,UROKINASE predisposes thrombotic disease,3745,"Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.","Is the triple ""UROKINASE predisposes thrombotic disease"" supported by the sentence: ""Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.""?",False, -13590349,Buspirone causes depressive disorder,3746,"Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.","Is the triple ""Buspirone causes depressive disorder"" supported by the sentence: ""Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.""?",False, -7712722,Buspirone affects depressive disorder,3747,"The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.","Is the triple ""Buspirone affects depressive disorder"" supported by the sentence: ""The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.""?",False, -7425584,Buspirone affects physiological sexual disorder,3748,It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.,"Is the triple ""Buspirone affects physiological sexual disorder"" supported by the sentence: ""It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.""?",False, -19950288,Buspirone disrupts schizophrenia,3749,Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.,"Is the triple ""Buspirone disrupts schizophrenia"" supported by the sentence: ""Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.""?",False, -10992881,Buspirone disrupts anxiety,3750,"CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.","Is the triple ""Buspirone disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.""?",False, -19904227,Iodine related to thyroid tumor,3751,Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.,"Is the triple ""Iodine related to thyroid tumor"" supported by the sentence: ""Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.""?",False, -10048388,Iodine related to breast neoplasm,3752,"Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.","Is the triple ""Iodine related to breast neoplasm"" supported by the sentence: ""Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.""?",False, -10651106,Iodine causes thyroid tumor,3753,Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.,"Is the triple ""Iodine causes thyroid tumor"" supported by the sentence: ""Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.""?",False, -10745802,Iodine affects thyroid tumor,3754,Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.,"Is the triple ""Iodine affects thyroid tumor"" supported by the sentence: ""Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.""?",False, -24773674,Iodine prevents thyroid tumor,3755,These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.,"Is the triple ""Iodine prevents thyroid tumor"" supported by the sentence: ""These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.""?",False, -27167996,Iodine predisposes thyroid tumor,3756,Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.,"Is the triple ""Iodine predisposes thyroid tumor"" supported by the sentence: ""Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.""?",False, -7362584,Acetaminophen subclass of Acetaminophen sulfate,3757,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen sulfate"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, -7362582,Acetaminophen subclass of Acetaminophen glucuronide,3758,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen glucuronide"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, -26133523,Acetaminophen related to neoplasm,3759,"None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.","Is the triple ""Acetaminophen related to neoplasm"" supported by the sentence: ""None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.""?",False, -25084939,Acetaminophen related to Acetimidoquinone,3760,"Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.","Is the triple ""Acetaminophen related to Acetimidoquinone"" supported by the sentence: ""Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.""?",False, -24055705,Acetaminophen related to osteoarthritis,3761,"As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.","Is the triple ""Acetaminophen related to osteoarthritis"" supported by the sentence: ""As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.""?",False, -20371329,Acetaminophen related to digestive system disorder,3762,Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.,"Is the triple ""Acetaminophen related to digestive system disorder"" supported by the sentence: ""Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.""?",False, -19637295,Acetaminophen related to Renal Colic,3763,"METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.","Is the triple ""Acetaminophen related to Renal Colic"" supported by the sentence: ""METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.""?",False, -16009572,Acetaminophen related to rheumatoid arthritis,3764,"The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).","Is the triple ""Acetaminophen related to rheumatoid arthritis"" supported by the sentence: ""The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).""?",False, -12233599,Acetaminophen related to Acetaminophen glucuronide,3765,The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.,"Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.""?",False, -12541409,Acetaminophen related to Acetaminophen glucuronide,3766,"The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).","Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).""?",False, -15777318,Acetaminophen coexists with Acetimidoquinone,3767,"In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.","Is the triple ""Acetaminophen coexists with Acetimidoquinone"" supported by the sentence: ""In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.""?",False, -18513016,Acetaminophen derives from Acetimidoquinone,3768,"Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.","Is the triple ""Acetaminophen derives from Acetimidoquinone"" supported by the sentence: ""Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.""?",False, -16596646,Acetaminophen derives from Acetaminophen glucuronide,3769,Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.,"Is the triple ""Acetaminophen derives from Acetaminophen glucuronide"" supported by the sentence: ""Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.""?",False, -7891577,Acetaminophen physically interacts with Acetimidoquinone,3770,"Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.""?",False, -11100770,Acetaminophen physically interacts with Acetimidoquinone,3771,"All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).""?",False, -8441876,Acetaminophen physically interacts with Acetaminophen glucuronide,3772,"Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.","Is the triple ""Acetaminophen physically interacts with Acetaminophen glucuronide"" supported by the sentence: ""Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.""?",False, -25685005,Acetaminophen causes neoplasm,3773,No pathologic or statistical evidence of induction of tumors by AAP was found.,"Is the triple ""Acetaminophen causes neoplasm"" supported by the sentence: ""No pathologic or statistical evidence of induction of tumors by AAP was found.""?",False, -24327037,Acetaminophen causes anxiety,3774,"In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.","Is the triple ""Acetaminophen causes anxiety"" supported by the sentence: ""In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.""?",False, -23482103,Acetaminophen causes nervous system disorder,3775,"Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.","Is the triple ""Acetaminophen causes nervous system disorder"" supported by the sentence: ""Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.""?",False, -21920646,Acetaminophen causes type 1 diabetes mellitus,3776,"A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.","Is the triple ""Acetaminophen causes type 1 diabetes mellitus"" supported by the sentence: ""A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.""?",False, -21160030,Acetaminophen causes Postoperative Nausea and Vomiting,3777,Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.,"Is the triple ""Acetaminophen causes Postoperative Nausea and Vomiting"" supported by the sentence: ""Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.""?",False, -19409287,Acetaminophen causes myopia,3778,ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.,"Is the triple ""Acetaminophen causes myopia"" supported by the sentence: ""ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.""?",False, -17485084,Acetaminophen causes obesity disorder,3779,Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.,"Is the triple ""Acetaminophen causes obesity disorder"" supported by the sentence: ""Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.""?",False, -17093716,Acetaminophen causes kidney disorder,3780,"PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.","Is the triple ""Acetaminophen causes kidney disorder"" supported by the sentence: ""PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.""?",False, -16903597,Acetaminophen causes hypertensive disorder,3781,"Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.","Is the triple ""Acetaminophen causes hypertensive disorder"" supported by the sentence: ""Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.""?",False, -16867510,Acetaminophen causes delirium,3782,Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.,"Is the triple ""Acetaminophen causes delirium"" supported by the sentence: ""Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.""?",False, -16756158,Acetaminophen causes osteoarthritis,3783,"Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.","Is the triple ""Acetaminophen causes osteoarthritis"" supported by the sentence: ""Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.""?",False, -16155885,Acetaminophen causes Hemorrhage,3784,"CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.","Is the triple ""Acetaminophen causes Hemorrhage"" supported by the sentence: ""CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.""?",False, -15922778,Acetaminophen causes Pruritus,3785,"Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.","Is the triple ""Acetaminophen causes Pruritus"" supported by the sentence: ""Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.""?",False, -14972793,Acetaminophen causes brain injury,3786,High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.,"Is the triple ""Acetaminophen causes brain injury"" supported by the sentence: ""High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.""?",False, -12302511,Acetaminophen causes Headache,3787,"Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.","Is the triple ""Acetaminophen causes Headache"" supported by the sentence: ""Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.""?",False, -9507087,Acetaminophen causes Vomiting,3788,A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.,"Is the triple ""Acetaminophen causes Vomiting"" supported by the sentence: ""A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.""?",False, -8697178,Acetaminophen causes Pain,3789,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Pain"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, -8697177,Acetaminophen causes Fever,3790,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Fever"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, -7330301,Acetaminophen causes injury,3791,"Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.","Is the triple ""Acetaminophen causes injury"" supported by the sentence: ""Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.""?",False, -24793249,Acetaminophen affects hypertensive disorder,3792,Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.,"Is the triple ""Acetaminophen affects hypertensive disorder"" supported by the sentence: ""Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.""?",False, -23912807,Acetaminophen affects Vomiting,3793,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, -23912806,Acetaminophen affects Nausea,3794,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, -23442508,Acetaminophen affects pharyngitis,3795,"The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.","Is the triple ""Acetaminophen affects pharyngitis"" supported by the sentence: ""The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.""?",False, -23226380,Acetaminophen affects anxiety,3796,"Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.","Is the triple ""Acetaminophen affects anxiety"" supported by the sentence: ""Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.""?",False, -22849168,Acetaminophen affects neoplasm,3797,The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.,"Is the triple ""Acetaminophen affects neoplasm"" supported by the sentence: ""The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.""?",False, -22389406,Acetaminophen affects Low back pain,3798,"This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.","Is the triple ""Acetaminophen affects Low back pain"" supported by the sentence: ""This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.""?",False, -22267005,Acetaminophen affects Acute Pain,3799,"Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.","Is the triple ""Acetaminophen affects Acute Pain"" supported by the sentence: ""Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.""?",False, -21609859,Acetaminophen affects migraine disorder,3800,The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.,"Is the triple ""Acetaminophen affects migraine disorder"" supported by the sentence: ""The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.""?",False, -21375424,Acetaminophen affects preeclampsia,3801,"Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.","Is the triple ""Acetaminophen affects preeclampsia"" supported by the sentence: ""Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.""?",False, -21166764,Acetaminophen affects Parkinson disease,3802,"Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.","Is the triple ""Acetaminophen affects Parkinson disease"" supported by the sentence: ""Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.""?",False, -20477729,Acetaminophen affects Hemorrhage,3803,"RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).","Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).""?",False, -20447454,Acetaminophen affects rheumatoid arthritis,3804,"Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.","Is the triple ""Acetaminophen affects rheumatoid arthritis"" supported by the sentence: ""Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.""?",False, -19937801,Acetaminophen affects Pain,3805,Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.,"Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.""?",False, -19285056,Acetaminophen affects Renal Colic,3806,"BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.","Is the triple ""Acetaminophen affects Renal Colic"" supported by the sentence: ""BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.""?",False, -18899993,Acetaminophen affects Abdominal pain,3807,Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).,"Is the triple ""Acetaminophen affects Abdominal pain"" supported by the sentence: ""Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).""?",False, -18709599,Acetaminophen affects Acetimidoquinone,3808,The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.,"Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.""?",False, -18394888,Acetaminophen affects Headache,3809,"She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.","Is the triple ""Acetaminophen affects Headache"" supported by the sentence: ""She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.""?",False, -18298999,Acetaminophen affects patent ductus arteriosus,3810,Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.,"Is the triple ""Acetaminophen affects patent ductus arteriosus"" supported by the sentence: ""Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.""?",False, -16707575,Acetaminophen affects obesity disorder,3811,"The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.","Is the triple ""Acetaminophen affects obesity disorder"" supported by the sentence: ""The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.""?",False, -16662805,Acetaminophen affects Vomiting,3812,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, -16662804,Acetaminophen affects Nausea,3813,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, -15922777,Acetaminophen affects Pruritus,3814,Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.,"Is the triple ""Acetaminophen affects Pruritus"" supported by the sentence: ""Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.""?",False, -15909356,Acetaminophen affects Postoperative Nausea and Vomiting,3815,OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.,"Is the triple ""Acetaminophen affects Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.""?",False, -12673406,Acetaminophen affects bone fracture,3816,"For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).","Is the triple ""Acetaminophen affects bone fracture"" supported by the sentence: ""For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).""?",False, -12488756,Acetaminophen affects Acetaminophen glucuronide,3817,"The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.""?",False, -11625632,Acetaminophen affects Chronic pain,3818,The role of paracetamol in chronic pain: an evidence-based approach.,"Is the triple ""Acetaminophen affects Chronic pain"" supported by the sentence: ""The role of paracetamol in chronic pain: an evidence-based approach.""?",False, -11439823,Acetaminophen affects type 1 diabetes mellitus,3819,"The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.","Is the triple ""Acetaminophen affects type 1 diabetes mellitus"" supported by the sentence: ""The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.""?",False, -11319146,Acetaminophen affects neuralgia,3820,The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.,"Is the triple ""Acetaminophen affects neuralgia"" supported by the sentence: ""The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.""?",False, -11289717,Acetaminophen affects osteoarthritis,3821,"Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.","Is the triple ""Acetaminophen affects osteoarthritis"" supported by the sentence: ""Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.""?",False, -11227783,Acetaminophen affects Fever,3822,Young age and high fever were associated with significantly higher acetaminophen levels.,"Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Young age and high fever were associated with significantly higher acetaminophen levels.""?",False, -11159989,Acetaminophen affects Hemorrhage,3823,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?",False, -10410536,Acetaminophen affects injury,3824,Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).,"Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).""?",False, -10195419,Acetaminophen affects Pain,3825,"The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.","Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.""?",False, -9259287,Acetaminophen affects Fever,3826,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, -8642669,Acetaminophen affects Hemorrhage,3827,CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.""?",False, -8097597,Acetaminophen affects injury,3828,"These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.","Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.""?",False, -25639149,Acetaminophen affects Acetaminophen glucuronide,3829,"Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.""?",False, -20782169,Acetaminophen affects Acetimidoquinone,3830,"Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.","Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.""?",False, -25481457,Acetaminophen disrupts patent ductus arteriosus,3831,"Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.","Is the triple ""Acetaminophen disrupts patent ductus arteriosus"" supported by the sentence: ""Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.""?",False, -25355292,Acetaminophen disrupts delirium,3832,"Individually, acetaminophen was associated with reduced delirium.","Is the triple ""Acetaminophen disrupts delirium"" supported by the sentence: ""Individually, acetaminophen was associated with reduced delirium.""?",False, -19614622,Acetaminophen disrupts Headache,3833,The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.,"Is the triple ""Acetaminophen disrupts Headache"" supported by the sentence: ""The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.""?",False, -16273113,Acetaminophen disrupts Fever,3834,"Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.","Is the triple ""Acetaminophen disrupts Fever"" supported by the sentence: ""Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.""?",False, -12102031,Acetaminophen disrupts Pain,3835,Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.,"Is the triple ""Acetaminophen disrupts Pain"" supported by the sentence: ""Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.""?",False, -7794905,Acetaminophen disrupts influenza,3836,"Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.","Is the triple ""Acetaminophen disrupts influenza"" supported by the sentence: ""Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.""?",False, -7640332,Acetaminophen disrupts injury,3837,"RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).","Is the triple ""Acetaminophen disrupts injury"" supported by the sentence: ""RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).""?",False, -26559635,Acetaminophen prevents malaria,3838,Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.,"Is the triple ""Acetaminophen prevents malaria"" supported by the sentence: ""Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.""?",False, -22159381,Acetaminophen prevents Hemorrhage,3839,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.","Is the triple ""Acetaminophen prevents Hemorrhage"" supported by the sentence: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?",False, -22123298,Acetaminophen prevents Fever,3840,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,"Is the triple ""Acetaminophen prevents Fever"" supported by the sentence: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?",False, -20154151,Acetaminophen prevents neuralgia,3841,"Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.","Is the triple ""Acetaminophen prevents neuralgia"" supported by the sentence: ""Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.""?",False, -20107193,Acetaminophen prevents delirium,3842,The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.,"Is the triple ""Acetaminophen prevents delirium"" supported by the sentence: ""The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.""?",False, -19168014,Acetaminophen prevents obesity disorder,3843,AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.,"Is the triple ""Acetaminophen prevents obesity disorder"" supported by the sentence: ""AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.""?",False, -19006111,Acetaminophen prevents patent ductus arteriosus,3844,Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.,"Is the triple ""Acetaminophen prevents patent ductus arteriosus"" supported by the sentence: ""Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.""?",False, -18131378,Acetaminophen prevents Low back pain,3845,CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.,"Is the triple ""Acetaminophen prevents Low back pain"" supported by the sentence: ""CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.""?",False, -18033682,Acetaminophen prevents Vomiting,3846,"Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).","Is the triple ""Acetaminophen prevents Vomiting"" supported by the sentence: ""Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).""?",False, -16975983,Acetaminophen prevents neoplasm,3847,Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.,"Is the triple ""Acetaminophen prevents neoplasm"" supported by the sentence: ""Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.""?",False, -16828191,Acetaminophen prevents rheumatoid arthritis,3848,"RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.","Is the triple ""Acetaminophen prevents rheumatoid arthritis"" supported by the sentence: ""RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.""?",False, -16784082,Acetaminophen prevents injury,3849,Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.,"Is the triple ""Acetaminophen prevents injury"" supported by the sentence: ""Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.""?",False, -16782348,Acetaminophen prevents Nausea,3850,"When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).","Is the triple ""Acetaminophen prevents Nausea"" supported by the sentence: ""When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).""?",False, -15909357,Acetaminophen prevents Postoperative Nausea and Vomiting,3851,CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.,"Is the triple ""Acetaminophen prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.""?",False, -15525446,Acetaminophen prevents Acute Pain,3852,Review: acetaminophen reduces acute migraine pain in adults.,"Is the triple ""Acetaminophen prevents Acute Pain"" supported by the sentence: ""Review: acetaminophen reduces acute migraine pain in adults.""?",False, -15467414,Acetaminophen prevents influenza,3853,METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.,"Is the triple ""Acetaminophen prevents influenza"" supported by the sentence: ""METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.""?",False, -14660734,Acetaminophen prevents cardiac rhythm disease,3854,"This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.","Is the triple ""Acetaminophen prevents cardiac rhythm disease"" supported by the sentence: ""This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.""?",False, -14372292,Acetaminophen prevents Headache,3855,"Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.","Is the triple ""Acetaminophen prevents Headache"" supported by the sentence: ""Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.""?",False, -13804263,Acetaminophen prevents type 2 diabetes mellitus,3856,"We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.","Is the triple ""Acetaminophen prevents type 2 diabetes mellitus"" supported by the sentence: ""We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.""?",False, -8695490,Acetaminophen prevents Pain,3857,"Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.","Is the triple ""Acetaminophen prevents Pain"" supported by the sentence: ""Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.""?",False, -25567880,Acetaminophen predisposes Sepsis,3858,Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?,"Is the triple ""Acetaminophen predisposes Sepsis"" supported by the sentence: ""Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?""?",False, -24917204,Acetaminophen predisposes type 2 diabetes mellitus,3859,"CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.","Is the triple ""Acetaminophen predisposes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.""?",False, -22230555,Acetaminophen predisposes delirium,3860,"Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.","Is the triple ""Acetaminophen predisposes delirium"" supported by the sentence: ""Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.""?",False, -21723139,Acetaminophen predisposes Hemorrhage,3861,"Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.","Is the triple ""Acetaminophen predisposes Hemorrhage"" supported by the sentence: ""Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.""?",False, -20594449,Acetaminophen predisposes neoplasm,3862,"The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Acetaminophen predisposes neoplasm"" supported by the sentence: ""The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).""?",False, -19914508,Acetaminophen predisposes Pain,3863,"Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.","Is the triple ""Acetaminophen predisposes Pain"" supported by the sentence: ""Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.""?",False, -16209480,Acetaminophen predisposes kidney disorder,3864,Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).,"Is the triple ""Acetaminophen predisposes kidney disorder"" supported by the sentence: ""Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).""?",False, -13597848,Acetaminophen predisposes injury,3865,"After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.","Is the triple ""Acetaminophen predisposes injury"" supported by the sentence: ""After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.""?",False, -13536066,Acetaminophen predisposes non-small cell lung carcinoma,3866,"METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.","Is the triple ""Acetaminophen predisposes non-small cell lung carcinoma"" supported by the sentence: ""METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.""?",False, -12673403,Acetaminophen predisposes bone fracture,3867,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Acetaminophen predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, -12109634,Acetaminophen predisposes Parkinson disease,3868,"No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.","Is the triple ""Acetaminophen predisposes Parkinson disease"" supported by the sentence: ""No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.""?",False, -11873681,Acetaminophen predisposes non-Hodgkin lymphoma,3869,"Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.","Is the triple ""Acetaminophen predisposes non-Hodgkin lymphoma"" supported by the sentence: ""Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.""?",False, -9834508,Acetaminophen predisposes hypertensive disorder,3870,"CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.","Is the triple ""Acetaminophen predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.""?",False, -8862839,Acetaminophen predisposes streptococcal infection,3871,Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.,"Is the triple ""Acetaminophen predisposes streptococcal infection"" supported by the sentence: ""Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.""?",False, -10289439,Chlorthalidone related to hypertensive disorder,3872,Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.,"Is the triple ""Chlorthalidone related to hypertensive disorder"" supported by the sentence: ""Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.""?",False, -10185607,Chlorthalidone related to coronary artery disorder,3873,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to coronary artery disorder"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, -10185606,Chlorthalidone related to myocardial infarction,3874,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to myocardial infarction"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, -7839079,Chlorthalidone related to essential hypertension,3875,Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.,"Is the triple ""Chlorthalidone related to essential hypertension"" supported by the sentence: ""Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.""?",False, -21616164,Chlorthalidone affects myocardial infarction,3876,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects myocardial infarction"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, -21616163,Chlorthalidone affects coronary artery disorder,3877,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects coronary artery disorder"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, -16399514,Chlorthalidone affects essential hypertension,3878,"In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.","Is the triple ""Chlorthalidone affects essential hypertension"" supported by the sentence: ""In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.""?",False, -16281975,Chlorthalidone affects hypertensive disorder,3879,"In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.","Is the triple ""Chlorthalidone affects hypertensive disorder"" supported by the sentence: ""In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.""?",False, -11587035,Chlorthalidone affects diabetes mellitus,3880,Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.,"Is the triple ""Chlorthalidone affects diabetes mellitus"" supported by the sentence: ""Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.""?",False, -11095498,Chlorthalidone prevents myocardial infarction,3881,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents myocardial infarction"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, -11095497,Chlorthalidone prevents coronary artery disorder,3882,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents coronary artery disorder"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, -8853238,Chlorthalidone prevents myocardial ischemia,3883,"CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.","Is the triple ""Chlorthalidone prevents myocardial ischemia"" supported by the sentence: ""CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.""?",False, -8036244,Chlorthalidone prevents hypertensive disorder,3884,"Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.","Is the triple ""Chlorthalidone prevents hypertensive disorder"" supported by the sentence: ""Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.""?",False, -11078982,Chlorthalidone predisposes coronary artery disorder,3885,"The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.","Is the triple ""Chlorthalidone predisposes coronary artery disorder"" supported by the sentence: ""The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.""?",False, -19123757,Propacetamol causes Pain,3886,"In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.","Is the triple ""Propacetamol causes Pain"" supported by the sentence: ""In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.""?",False, -11402898,Propacetamol prevents Pain,3887,BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.,"Is the triple ""Propacetamol prevents Pain"" supported by the sentence: ""BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.""?",False, -25540651,Isopropyl Alcohol affects Nausea,3888,"CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.","Is the triple ""Isopropyl Alcohol affects Nausea"" supported by the sentence: ""CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.""?",False, -18311094,Isopropyl Alcohol affects infectious disease,3889,CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.,"Is the triple ""Isopropyl Alcohol affects infectious disease"" supported by the sentence: ""CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.""?",False, -10697335,Isopropyl Alcohol affects burn,3890,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Isopropyl Alcohol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, -9427033,Isopropyl Alcohol prevents infectious disease,3891,"The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.","Is the triple ""Isopropyl Alcohol prevents infectious disease"" supported by the sentence: ""The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.""?",False, -21320482,Ethanol related to substance-related disorder,3892,"METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).","Is the triple ""Ethanol related to substance-related disorder"" supported by the sentence: ""METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).""?",False, -15908919,Ethanol related to hypertensive disorder,3893,"Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.","Is the triple ""Ethanol related to hypertensive disorder"" supported by the sentence: ""Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.""?",False, -14538852,Ethanol related to atrial fibrillation,3894,CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.,"Is the triple ""Ethanol related to atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.""?",False, -13852361,Ethanol related to obesity disorder,3895,"Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.","Is the triple ""Ethanol related to obesity disorder"" supported by the sentence: ""Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.""?",False, -27116018,Ethanol causes neutropenia,3896,"EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.","Is the triple ""Ethanol causes neutropenia"" supported by the sentence: ""EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.""?",False, -26520376,Ethanol causes essential hypertension,3897,"Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.","Is the triple ""Ethanol causes essential hypertension"" supported by the sentence: ""Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.""?",False, -17336935,Ethanol causes Tremor,3898,"We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.","Is the triple ""Ethanol causes Tremor"" supported by the sentence: ""We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.""?",False, -15073107,Ethanol causes alcohol-related disorders,3899,"CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.","Is the triple ""Ethanol causes alcohol-related disorders"" supported by the sentence: ""CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.""?",False, -14779551,Ethanol causes burn,3900,CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.,"Is the triple ""Ethanol causes burn"" supported by the sentence: ""CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.""?",False, -12227250,Ethanol causes bacterial infectious disease with sepsis,3901,Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.,"Is the triple ""Ethanol causes bacterial infectious disease with sepsis"" supported by the sentence: ""Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.""?",False, -11665347,Ethanol causes erectile dysfunction,3902,"Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.","Is the triple ""Ethanol causes erectile dysfunction"" supported by the sentence: ""Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.""?",False, -11096896,Ethanol causes type 2 diabetes mellitus,3903,"Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.","Is the triple ""Ethanol causes type 2 diabetes mellitus"" supported by the sentence: ""Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.""?",False, -10962858,Ethanol causes atrial fibrillation,3904,This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.,"Is the triple ""Ethanol causes atrial fibrillation"" supported by the sentence: ""This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.""?",False, -9159992,Ethanol causes obesity disorder,3905,"In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.","Is the triple ""Ethanol causes obesity disorder"" supported by the sentence: ""In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.""?",False, -8743651,Ethanol causes alcohol abuse,3906,"Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.","Is the triple ""Ethanol causes alcohol abuse"" supported by the sentence: ""Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.""?",False, -8636726,Ethanol causes major depressive disorder,3907,"For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.","Is the triple ""Ethanol causes major depressive disorder"" supported by the sentence: ""For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.""?",False, -8268450,Ethanol causes atopic eczema,3908,Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.,"Is the triple ""Ethanol causes atopic eczema"" supported by the sentence: ""Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.""?",False, -7771647,Ethanol causes hypertensive disorder,3909,High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.,"Is the triple ""Ethanol causes hypertensive disorder"" supported by the sentence: ""High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.""?",False, -7460012,Ethanol causes cirrhosis of liver,3910,[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].,"Is the triple ""Ethanol causes cirrhosis of liver"" supported by the sentence: ""[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].""?",False, -27580478,Ethanol affects cirrhosis of liver,3911,CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.,"Is the triple ""Ethanol affects cirrhosis of liver"" supported by the sentence: ""CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.""?",False, -27514790,Ethanol affects Thyroid nodule,3912,"In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.","Is the triple ""Ethanol affects Thyroid nodule"" supported by the sentence: ""In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.""?",False, -26762447,Ethanol affects neutropenia,3913,"To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).","Is the triple ""Ethanol affects neutropenia"" supported by the sentence: ""To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).""?",False, -23912654,Ethanol affects atrial fibrillation,3914,"Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.""?",False, -23763968,Ethanol affects substance-related disorder,3915,"CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.","Is the triple ""Ethanol affects substance-related disorder"" supported by the sentence: ""CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.""?",False, -19533165,Ethanol affects hypertensive disorder,3916,"As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.","Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.""?",False, -19155713,Ethanol affects cannabis dependence,3917,"Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.","Is the triple ""Ethanol affects cannabis dependence"" supported by the sentence: ""Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.""?",False, -16819917,Ethanol affects Chronic pain,3918,"INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.""?",False, -15671844,Ethanol affects obesity disorder,3919,"The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.""?",False, -14737169,Ethanol affects Chronic pain,3920,"Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.""?",False, -14527564,Ethanol affects benign prostatic hyperplasia,3921,Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.,"Is the triple ""Ethanol affects benign prostatic hyperplasia"" supported by the sentence: ""Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.""?",False, -13226372,Ethanol affects atrial fibrillation,3922,"BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.""?",False, -12698965,Ethanol affects major depressive disorder,3923,"An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.""?",False, -12166837,Ethanol affects type 2 diabetes mellitus,3924,Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.""?",False, -10697334,Ethanol affects burn,3925,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, -9822489,Ethanol affects Tremor,3926,"Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.""?",False, -9174558,Ethanol affects Tremor,3927,"The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.""?",False, -9116052,Ethanol affects major depressive disorder,3928,"RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.""?",False, -8931619,Ethanol affects hypertensive disorder,3929,The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.,"Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.""?",False, -8730041,Ethanol affects burn,3930,"Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.""?",False, -8616967,Ethanol affects type 2 diabetes mellitus,3931,CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.""?",False, -8569555,Ethanol affects alcohol abuse,3932,"This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.""?",False, -8363507,Ethanol affects obesity disorder,3933,"Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.""?",False, -7210977,Ethanol affects alcohol abuse,3934,"CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.""?",False, -25366419,Ethanol disrupts ventricular tachycardia,3935,"However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.","Is the triple ""Ethanol disrupts ventricular tachycardia"" supported by the sentence: ""However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.""?",False, -24747388,Ethanol disrupts obesity disorder,3936,"In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.","Is the triple ""Ethanol disrupts obesity disorder"" supported by the sentence: ""In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.""?",False, -22793590,Ethanol disrupts Infection,3937,"In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.","Is the triple ""Ethanol disrupts Infection"" supported by the sentence: ""In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.""?",False, -20664067,Ethanol disrupts Chronic pain,3938,"Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).","Is the triple ""Ethanol disrupts Chronic pain"" supported by the sentence: ""Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).""?",False, -19084276,Ethanol disrupts hypertensive disorder,3939,"Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.","Is the triple ""Ethanol disrupts hypertensive disorder"" supported by the sentence: ""Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.""?",False, -15586620,Ethanol disrupts Tremor,3940,Temporary suppression of the tremor by alcohol is seen in about one-third of cases.,"Is the triple ""Ethanol disrupts Tremor"" supported by the sentence: ""Temporary suppression of the tremor by alcohol is seen in about one-third of cases.""?",False, -15580442,Ethanol disrupts atrial fibrillation,3941,"In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).","Is the triple ""Ethanol disrupts atrial fibrillation"" supported by the sentence: ""In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).""?",False, -12535146,Ethanol disrupts type 2 diabetes mellitus,3942,Alcohol from wine was associated with reduced risk of Type 2 diabetes.,"Is the triple ""Ethanol disrupts type 2 diabetes mellitus"" supported by the sentence: ""Alcohol from wine was associated with reduced risk of Type 2 diabetes.""?",False, -9920913,Ethanol disrupts constipation disorder,3943,"Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).","Is the triple ""Ethanol disrupts constipation disorder"" supported by the sentence: ""Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).""?",False, -27717904,Ethanol prevents cirrhosis of liver,3944,HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.,"Is the triple ""Ethanol prevents cirrhosis of liver"" supported by the sentence: ""HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.""?",False, -22976273,Ethanol prevents Infection,3945,Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.,"Is the triple ""Ethanol prevents Infection"" supported by the sentence: ""Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.""?",False, -21338360,Ethanol prevents atrial fibrillation,3946,Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.,"Is the triple ""Ethanol prevents atrial fibrillation"" supported by the sentence: ""Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.""?",False, -20664068,Ethanol prevents Chronic pain,3947,An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.,"Is the triple ""Ethanol prevents Chronic pain"" supported by the sentence: ""An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.""?",False, -14465260,Ethanol prevents bacterial infectious disease with sepsis,3948,Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.,"Is the triple ""Ethanol prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.""?",False, -13158318,Ethanol prevents erectile dysfunction,3949,More research is needed to confirm whether alcohol is protective or is unrelated to ED development.,"Is the triple ""Ethanol prevents erectile dysfunction"" supported by the sentence: ""More research is needed to confirm whether alcohol is protective or is unrelated to ED development.""?",False, -12078103,Ethanol prevents alcohol abuse,3950,"Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.","Is the triple ""Ethanol prevents alcohol abuse"" supported by the sentence: ""Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.""?",False, -11890775,Ethanol prevents type 2 diabetes mellitus,3951,Alcohol for the prevention of type 2 diabetes mellitus?,"Is the triple ""Ethanol prevents type 2 diabetes mellitus"" supported by the sentence: ""Alcohol for the prevention of type 2 diabetes mellitus?""?",False, -11547578,Ethanol prevents Tremor,3952,"Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.","Is the triple ""Ethanol prevents Tremor"" supported by the sentence: ""Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.""?",False, -10032139,Ethanol prevents obesity disorder,3953,"During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.","Is the triple ""Ethanol prevents obesity disorder"" supported by the sentence: ""During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.""?",False, -8207881,Ethanol prevents hypertensive disorder,3954,Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.,"Is the triple ""Ethanol prevents hypertensive disorder"" supported by the sentence: ""Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.""?",False, -26228661,Ethanol predisposes essential hypertension,3955,"Alcohol, personality and predisposition to essential hypertension.","Is the triple ""Ethanol predisposes essential hypertension"" supported by the sentence: ""Alcohol, personality and predisposition to essential hypertension.""?",False, -23006394,Ethanol predisposes constipation disorder,3956,"The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.","Is the triple ""Ethanol predisposes constipation disorder"" supported by the sentence: ""The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.""?",False, -21458894,Ethanol predisposes burn,3957,The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.,"Is the triple ""Ethanol predisposes burn"" supported by the sentence: ""The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.""?",False, -21015200,Ethanol predisposes benign prostatic hyperplasia,3958,The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.,"Is the triple ""Ethanol predisposes benign prostatic hyperplasia"" supported by the sentence: ""The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.""?",False, -20014749,Ethanol predisposes neuroblastoma,3959,"STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.","Is the triple ""Ethanol predisposes neuroblastoma"" supported by the sentence: ""STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.""?",False, -19550164,Ethanol predisposes endometriosis,3960,"Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.","Is the triple ""Ethanol predisposes endometriosis"" supported by the sentence: ""Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.""?",False, -15239058,Ethanol predisposes cannabis dependence,3961,"Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.","Is the triple ""Ethanol predisposes cannabis dependence"" supported by the sentence: ""Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.""?",False, -13742110,Ethanol predisposes cirrhosis of liver,3962,"It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.","Is the triple ""Ethanol predisposes cirrhosis of liver"" supported by the sentence: ""It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.""?",False, -13158317,Ethanol predisposes erectile dysfunction,3963,"Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.","Is the triple ""Ethanol predisposes erectile dysfunction"" supported by the sentence: ""Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.""?",False, -11801709,Ethanol predisposes type 2 diabetes mellitus,3964,No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.,"Is the triple ""Ethanol predisposes type 2 diabetes mellitus"" supported by the sentence: ""No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.""?",False, -11652545,Ethanol predisposes obesity disorder,3965,Alcohol could contribute to obesity.,"Is the triple ""Ethanol predisposes obesity disorder"" supported by the sentence: ""Alcohol could contribute to obesity.""?",False, -11461204,Ethanol predisposes atrial fibrillation,3966,"In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.","Is the triple ""Ethanol predisposes atrial fibrillation"" supported by the sentence: ""In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.""?",False, -9864711,Ethanol predisposes major depressive disorder,3967,"Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.","Is the triple ""Ethanol predisposes major depressive disorder"" supported by the sentence: ""Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.""?",False, -9226083,Ethanol predisposes alcohol abuse,3968,BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.,"Is the triple ""Ethanol predisposes alcohol abuse"" supported by the sentence: ""BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.""?",False, -8895200,Ethanol predisposes hypertensive disorder,3969,The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.,"Is the triple ""Ethanol predisposes hypertensive disorder"" supported by the sentence: ""The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.""?",False, -22402878,Sodium Hypochlorite related to Infection,3970,Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.,"Is the triple ""Sodium Hypochlorite related to Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.""?",False, -22402879,Sodium Hypochlorite prevents Infection,3971,"Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.","Is the triple ""Sodium Hypochlorite prevents Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.""?",False, -22325598,Sodium Hypochlorite prevents Pain,3972,"Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.","Is the triple ""Sodium Hypochlorite prevents Pain"" supported by the sentence: ""Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.""?",False, -23522159,Hydrogen Peroxide related to gingivitis,3973,"Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.","Is the triple ""Hydrogen Peroxide related to gingivitis"" supported by the sentence: ""Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.""?",False, -10185817,Hydrogen Peroxide related to acne,3974,STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.,"Is the triple ""Hydrogen Peroxide related to acne"" supported by the sentence: ""STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.""?",False, -9091124,Hydrogen Peroxide related to injury,3975,Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.,"Is the triple ""Hydrogen Peroxide related to injury"" supported by the sentence: ""Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.""?",False, -21979927,Hydrogen Peroxide causes seborrheic keratosis,3976,Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.,"Is the triple ""Hydrogen Peroxide causes seborrheic keratosis"" supported by the sentence: ""Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.""?",False, -7121153,Hydrogen Peroxide causes injury,3977,Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.,"Is the triple ""Hydrogen Peroxide causes injury"" supported by the sentence: ""Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.""?",False, -18988282,Hydrogen Peroxide affects severe acute respiratory syndrome,3978,"Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.","Is the triple ""Hydrogen Peroxide affects severe acute respiratory syndrome"" supported by the sentence: ""Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.""?",False, -15261236,Hydrogen Peroxide affects gingivitis,3979,"Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.","Is the triple ""Hydrogen Peroxide affects gingivitis"" supported by the sentence: ""Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.""?",False, -9489971,Hydrogen Peroxide affects injury,3980,Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.""?",False, -7188934,Hydrogen Peroxide affects injury,3981,These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.""?",False, -20490056,Hydrogen Peroxide disrupts dental caries,3982,"Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.","Is the triple ""Hydrogen Peroxide disrupts dental caries"" supported by the sentence: ""Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.""?",False, -17081431,Hydrogen Peroxide disrupts injury,3983,Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.,"Is the triple ""Hydrogen Peroxide disrupts injury"" supported by the sentence: ""Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.""?",False, -8804977,Hydrogen Peroxide disrupts gingivitis,3984,CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.,"Is the triple ""Hydrogen Peroxide disrupts gingivitis"" supported by the sentence: ""CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.""?",False, -21124110,Hydrogen Peroxide prevents acne,3985,"Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.","Is the triple ""Hydrogen Peroxide prevents acne"" supported by the sentence: ""Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.""?",False, -11091070,Hydrogen Peroxide prevents gingivitis,3986,CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.,"Is the triple ""Hydrogen Peroxide prevents gingivitis"" supported by the sentence: ""CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.""?",False, -7482647,Hydrogen Peroxide prevents injury,3987,"Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.","Is the triple ""Hydrogen Peroxide prevents injury"" supported by the sentence: ""Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.""?",False, -19925807,Hydrogen Peroxide predisposes dental caries,3988,"Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.","Is the triple ""Hydrogen Peroxide predisposes dental caries"" supported by the sentence: ""Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.""?",False, -10852631,Hydrogen Peroxide predisposes injury,3989,Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.,"Is the triple ""Hydrogen Peroxide predisposes injury"" supported by the sentence: ""Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.""?",False, -23181733,Vitamin K1 related to Hemorrhage,3990,"Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).","Is the triple ""Vitamin K1 related to Hemorrhage"" supported by the sentence: ""Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).""?",False, -20221966,Vitamin K1 related to postmenopausal osteoporosis,3991,Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.,"Is the triple ""Vitamin K1 related to postmenopausal osteoporosis"" supported by the sentence: ""Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.""?",False, -19764095,Vitamin K1 related to osteoporosis,3992,Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.,"Is the triple ""Vitamin K1 related to osteoporosis"" supported by the sentence: ""Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.""?",False, -17682094,Vitamin K1 related to atrial fibrillation,3993,We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.,"Is the triple ""Vitamin K1 related to atrial fibrillation"" supported by the sentence: ""We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.""?",False, -13777524,Vitamin K1 related to cystic fibrosis,3994,Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.,"Is the triple ""Vitamin K1 related to cystic fibrosis"" supported by the sentence: ""Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.""?",False, -11304774,Vitamin K1 affects Hemorrhage,3995,"RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.","Is the triple ""Vitamin K1 affects Hemorrhage"" supported by the sentence: ""RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.""?",False, -24408540,Vitamin K1 prevents Hemorrhage,3996,OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.,"Is the triple ""Vitamin K1 prevents Hemorrhage"" supported by the sentence: ""OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.""?",False, -13476259,Vitamin K1 prevents vitamin K deficiency hemorrhagic disease,3997,OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.,"Is the triple ""Vitamin K1 prevents vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.""?",False, -10772424,Vitamin K1 predisposes postmenopausal osteoporosis,3998,"If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.","Is the triple ""Vitamin K1 predisposes postmenopausal osteoporosis"" supported by the sentence: ""If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.""?",False, -9319754,Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease,3999,"Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.","Is the triple ""Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.""?",False, -24430542,Indapamide causes type 2 diabetes mellitus,4000,The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).,"Is the triple ""Indapamide causes type 2 diabetes mellitus"" supported by the sentence: ""The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).""?",False, -24430545,Indapamide affects type 2 diabetes mellitus,4001,"INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.","Is the triple ""Indapamide affects type 2 diabetes mellitus"" supported by the sentence: ""INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.""?",False, -10214767,Indapamide affects hypertensive disorder,4002,This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.,"Is the triple ""Indapamide affects hypertensive disorder"" supported by the sentence: ""This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.""?",False, -13327254,Indapamide prevents hypertensive disorder,4003,During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.,"Is the triple ""Indapamide prevents hypertensive disorder"" supported by the sentence: ""During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.""?",False, -18173402,Perphenazine related to schizophrenia,4004,Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.,"Is the triple ""Perphenazine related to schizophrenia"" supported by the sentence: ""Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.""?",False, -11307427,Perphenazine related to Postoperative Nausea and Vomiting,4005,"CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.","Is the triple ""Perphenazine related to Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.""?",False, -19924977,Perphenazine disrupts cocaine dependence,4006,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts cocaine dependence"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, -19924976,Perphenazine disrupts schizophrenia,4007,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts schizophrenia"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, -15171439,Perphenazine prevents Postoperative Nausea and Vomiting,4008,CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.,"Is the triple ""Perphenazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.""?",False, -27208453,Perphenazine exacerbates dementia,4009,We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.,"Is the triple ""Perphenazine exacerbates dementia"" supported by the sentence: ""We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.""?",False, -26847530,Fluphenazine affects psychotic disorder,4010,BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.,"Is the triple ""Fluphenazine affects psychotic disorder"" supported by the sentence: ""BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.""?",False, -11127872,Fluphenazine prevents psychotic disorder,4011,"Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.","Is the triple ""Fluphenazine prevents psychotic disorder"" supported by the sentence: ""Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.""?",False, -10396371,Prochlorperazine disrupts Nausea,4012,"A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.","Is the triple ""Prochlorperazine disrupts Nausea"" supported by the sentence: ""A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.""?",False, -11808182,Prochlorperazine prevents Postoperative Nausea and Vomiting,4013,"OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.","Is the triple ""Prochlorperazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.""?",False, -10634177,Prochlorperazine prevents migraine disorder,4014,Prevention of migraine in children by prochlorperazine.,"Is the triple ""Prochlorperazine prevents migraine disorder"" supported by the sentence: ""Prevention of migraine in children by prochlorperazine.""?",False, -7427448,Prochlorperazine prevents Nausea,4015,Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.,"Is the triple ""Prochlorperazine prevents Nausea"" supported by the sentence: ""Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.""?",False, -11272109,ELOSULFASE ALFA related to mucopolysaccharidosis type 4,4016,N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.,"Is the triple ""ELOSULFASE ALFA related to mucopolysaccharidosis type 4"" supported by the sentence: ""N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.""?",False, -26291786,ELOSULFASE ALFA derives from Keratan,4017,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, -26291786,ELOSULFASE ALFA derives from Keratan,4018,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, -16241796,ELOSULFASE ALFA physically interacts with Keratan,4019,"The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA physically interacts with Keratan"" supported by the sentence: ""The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, -16652816,ELOSULFASE ALFA causes mucopolysaccharidosis type 4,4020,PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.,"Is the triple ""ELOSULFASE ALFA causes mucopolysaccharidosis type 4"" supported by the sentence: ""PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.""?",False, -13130107,ELOSULFASE ALFA affects Keratan,4021,"Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA affects Keratan"" supported by the sentence: ""Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, -21593588,Pegvaliase related to phenylketonuria,4022,Case-control study about the acceptance of Pegvaliase in Phenylketonuria.,"Is the triple ""Pegvaliase related to phenylketonuria"" supported by the sentence: ""Case-control study about the acceptance of Pegvaliase in Phenylketonuria.""?",False, -23111774,Labetalol related to preeclampsia,4023,"To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.","Is the triple ""Labetalol related to preeclampsia"" supported by the sentence: ""To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.""?",False, -19865755,Labetalol related to hypertensive disorder,4024,"Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.","Is the triple ""Labetalol related to hypertensive disorder"" supported by the sentence: ""Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.""?",False, -19886747,Labetalol causes hypertensive disorder,4025,Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.,"Is the triple ""Labetalol causes hypertensive disorder"" supported by the sentence: ""Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.""?",False, -7968423,Labetalol causes hypotensive disorder,4026,"For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.","Is the triple ""Labetalol causes hypotensive disorder"" supported by the sentence: ""For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.""?",False, -26371124,Labetalol affects hypertensive disorder,4027,The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.""?",False, -16245918,Labetalol affects stroke disorder,4028,"BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.","Is the triple ""Labetalol affects stroke disorder"" supported by the sentence: ""BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.""?",False, -15472186,Labetalol affects hypertensive disorder,4029,The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.""?",False, -11424839,Labetalol affects hypotensive disorder,4030,The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.,"Is the triple ""Labetalol affects hypotensive disorder"" supported by the sentence: ""The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.""?",False, -24194004,Labetalol prevents preeclampsia,4031,"CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.","Is the triple ""Labetalol prevents preeclampsia"" supported by the sentence: ""CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.""?",False, -16282554,Labetalol prevents hypertensive disorder,4032,"Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.","Is the triple ""Labetalol prevents hypertensive disorder"" supported by the sentence: ""Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.""?",False, -16892434,Labetalol predisposes stroke disorder,4033,"Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.","Is the triple ""Labetalol predisposes stroke disorder"" supported by the sentence: ""Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.""?",False, -15232781,Carvedilol related to hypertensive disorder,4034,Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.,"Is the triple ""Carvedilol related to hypertensive disorder"" supported by the sentence: ""Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.""?",False, -15407113,Carvedilol causes Left ventricular hypertrophy,4035,Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.,"Is the triple ""Carvedilol causes Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.""?",False, -14049404,Carvedilol causes epilepsy,4036,Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.,"Is the triple ""Carvedilol causes epilepsy"" supported by the sentence: ""Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.""?",False, -19046224,Carvedilol affects esophageal varices,4037,Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.,"Is the triple ""Carvedilol affects esophageal varices"" supported by the sentence: ""Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.""?",False, -17542363,Carvedilol affects Left ventricular hypertrophy,4038,"Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.""?",False, -11530189,Carvedilol affects essential hypertension,4039,Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.,"Is the triple ""Carvedilol affects essential hypertension"" supported by the sentence: ""Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.""?",False, -11200172,Carvedilol affects atrial fibrillation,4040,Role of carvedilol in atrial fibrillation: insights from clinical trials.,"Is the triple ""Carvedilol affects atrial fibrillation"" supported by the sentence: ""Role of carvedilol in atrial fibrillation: insights from clinical trials.""?",False, -10614289,Carvedilol affects Stable angina,4041,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects Stable angina"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, -10614288,Carvedilol affects hypertensive disorder,4042,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, -10402879,Carvedilol affects hypertensive disorder,4043,"In addition, carvedilol reduced elevated blood pressure in allografted rats.","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""In addition, carvedilol reduced elevated blood pressure in allografted rats.""?",False, -9269217,Carvedilol affects Left ventricular hypertrophy,4044,"Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.""?",False, -9116913,Carvedilol affects cardiovascular disorder,4045,All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.,"Is the triple ""Carvedilol affects cardiovascular disorder"" supported by the sentence: ""All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.""?",False, -7256243,Carvedilol affects portal hypertension,4046,BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.,"Is the triple ""Carvedilol affects portal hypertension"" supported by the sentence: ""BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.""?",False, -24587957,Carvedilol disrupts portal hypertension,4047,"Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.","Is the triple ""Carvedilol disrupts portal hypertension"" supported by the sentence: ""Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.""?",False, -21108262,Carvedilol disrupts myocardial infarction,4048,"The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.","Is the triple ""Carvedilol disrupts myocardial infarction"" supported by the sentence: ""The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.""?",False, -13210472,Carvedilol disrupts atrial fibrillation,4049,"The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.","Is the triple ""Carvedilol disrupts atrial fibrillation"" supported by the sentence: ""The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.""?",False, -23631897,Carvedilol prevents neoplasm,4050,Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.,"Is the triple ""Carvedilol prevents neoplasm"" supported by the sentence: ""Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.""?",False, -23413400,Carvedilol prevents myocardial infarction,4051,Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.,"Is the triple ""Carvedilol prevents myocardial infarction"" supported by the sentence: ""Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.""?",False, -20796578,Carvedilol prevents hypoglycemia,4052,"To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.","Is the triple ""Carvedilol prevents hypoglycemia"" supported by the sentence: ""To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.""?",False, -17416516,Carvedilol prevents portal hypertension,4053,CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.,"Is the triple ""Carvedilol prevents portal hypertension"" supported by the sentence: ""CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.""?",False, -15996194,Carvedilol prevents hypertensive disorder,4054,Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.,"Is the triple ""Carvedilol prevents hypertensive disorder"" supported by the sentence: ""Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.""?",False, -15794060,Carvedilol prevents Abnormal left ventricular function,4055,Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.,"Is the triple ""Carvedilol prevents Abnormal left ventricular function"" supported by the sentence: ""Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.""?",False, -15707001,Carvedilol prevents kidney disorder,4056,"Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.","Is the triple ""Carvedilol prevents kidney disorder"" supported by the sentence: ""Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.""?",False, -12564717,Carvedilol prevents atrial fibrillation,4057,Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).,"Is the triple ""Carvedilol prevents atrial fibrillation"" supported by the sentence: ""Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).""?",False, -8686828,Carvedilol prevents Left ventricular hypertrophy,4058,Carvedilol reduced LVH by 20%.,"Is the triple ""Carvedilol prevents Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol reduced LVH by 20%.""?",False, -23747042,Carvedilol predisposes type 2 diabetes mellitus,4059,"However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.","Is the triple ""Carvedilol predisposes type 2 diabetes mellitus"" supported by the sentence: ""However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.""?",False, -22663350,Carvedilol predisposes atrial fibrillation,4060,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Carvedilol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, -21640789,Carvedilol predisposes hypoglycemia,4061,"This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.","Is the triple ""Carvedilol predisposes hypoglycemia"" supported by the sentence: ""This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.""?",False, -21331523,Carvedilol predisposes myocardial infarction,4062,The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).,"Is the triple ""Carvedilol predisposes myocardial infarction"" supported by the sentence: ""The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).""?",False, -20291576,Raloxifene related to schizophrenia,4063,A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.,"Is the triple ""Raloxifene related to schizophrenia"" supported by the sentence: ""A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.""?",False, -13558027,Raloxifene related to postmenopausal osteoporosis,4064,Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.,"Is the triple ""Raloxifene related to postmenopausal osteoporosis"" supported by the sentence: ""Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.""?",False, -27583128,Raloxifene causes breast neoplasm,4065,Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.,"Is the triple ""Raloxifene causes breast neoplasm"" supported by the sentence: ""Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.""?",False, -20242808,Raloxifene affects psychotic disorder,4066,"In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.","Is the triple ""Raloxifene affects psychotic disorder"" supported by the sentence: ""In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.""?",False, -16098538,Raloxifene affects schizophrenia,4067,Beneficial effects of add-on raloxifene in schizophrenia.,"Is the triple ""Raloxifene affects schizophrenia"" supported by the sentence: ""Beneficial effects of add-on raloxifene in schizophrenia.""?",False, -15267794,Raloxifene affects Marchiafava-Bignami disease,4068,"To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.","Is the triple ""Raloxifene affects Marchiafava-Bignami disease"" supported by the sentence: ""To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.""?",False, -11233936,Raloxifene affects breast neoplasm,4069,"OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.","Is the triple ""Raloxifene affects breast neoplasm"" supported by the sentence: ""OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.""?",False, -10869334,Raloxifene affects osteoporosis,4070,"While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.","Is the triple ""Raloxifene affects osteoporosis"" supported by the sentence: ""While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.""?",False, -9569313,Raloxifene affects postmenopausal osteoporosis,4071,"Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.","Is the triple ""Raloxifene affects postmenopausal osteoporosis"" supported by the sentence: ""Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.""?",False, -15267792,Raloxifene disrupts Marchiafava-Bignami disease,4072,Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.,"Is the triple ""Raloxifene disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.""?",False, -13369623,Raloxifene disrupts osteoporosis,4073,Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.,"Is the triple ""Raloxifene disrupts osteoporosis"" supported by the sentence: ""Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.""?",False, -7874352,Raloxifene disrupts postmenopausal osteoporosis,4074,The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.,"Is the triple ""Raloxifene disrupts postmenopausal osteoporosis"" supported by the sentence: ""The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.""?",False, -16984197,Raloxifene prevents Alzheimer disease,4075,"We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.","Is the triple ""Raloxifene prevents Alzheimer disease"" supported by the sentence: ""We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.""?",False, -12036378,Raloxifene prevents breast neoplasm,4076,"We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.","Is the triple ""Raloxifene prevents breast neoplasm"" supported by the sentence: ""We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.""?",False, -7813032,Raloxifene prevents postmenopausal osteoporosis,4077,Raloxifene to prevent postmenopausal osteoporosis.,"Is the triple ""Raloxifene prevents postmenopausal osteoporosis"" supported by the sentence: ""Raloxifene to prevent postmenopausal osteoporosis.""?",False, -7578651,Raloxifene prevents osteoporosis,4078,"Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.","Is the triple ""Raloxifene prevents osteoporosis"" supported by the sentence: ""Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.""?",False, -7570810,Raloxifene prevents Marchiafava-Bignami disease,4079,RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.,"Is the triple ""Raloxifene prevents Marchiafava-Bignami disease"" supported by the sentence: ""RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.""?",False, -11746046,Raloxifene predisposes Alzheimer disease,4080,"OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.","Is the triple ""Raloxifene predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.""?",False, -11350173,Raloxifene predisposes osteoporosis,4081,"Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.","Is the triple ""Raloxifene predisposes osteoporosis"" supported by the sentence: ""Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.""?",False, -23481448,Bazedoxifene acetate prevents osteoporosis,4082,"These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.","Is the triple ""Bazedoxifene acetate prevents osteoporosis"" supported by the sentence: ""These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.""?",False, -19905553,Ospemifene disrupts psychologic dyspareunia,4083,"In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.","Is the triple ""Ospemifene disrupts psychologic dyspareunia"" supported by the sentence: ""In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.""?",False, -15516940,Sufentanil affects Pain,4084,The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.,"Is the triple ""Sufentanil affects Pain"" supported by the sentence: ""The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.""?",False, -20743116,Sufentanil prevents delirium,4085,"CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.","Is the triple ""Sufentanil prevents delirium"" supported by the sentence: ""CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.""?",False, -8151024,Sufentanil prevents Pain,4086,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Sufentanil prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, -12819365,Streptomycin related to Buruli ulcer disease,4087,The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.,"Is the triple ""Streptomycin related to Buruli ulcer disease"" supported by the sentence: ""The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.""?",False, -11425591,Streptomycin related to osteomyelitis,4088,Streptomycin in chronic traumatic osteomyelitis.,"Is the triple ""Streptomycin related to osteomyelitis"" supported by the sentence: ""Streptomycin in chronic traumatic osteomyelitis.""?",False, -10417352,Streptomycin related to plague,4089,Role of streptomycin in plague.,"Is the triple ""Streptomycin related to plague"" supported by the sentence: ""Role of streptomycin in plague.""?",False, -10748245,Streptomycin causes plague,4090,[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].,"Is the triple ""Streptomycin causes plague"" supported by the sentence: ""[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].""?",False, -26655494,Streptomycin prevents mycobacterium avium complex disease,4091,"Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.","Is the triple ""Streptomycin prevents mycobacterium avium complex disease"" supported by the sentence: ""Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.""?",False, -14226518,Paromomycin related to cutaneous leishmaniasis,4092,"In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).","Is the triple ""Paromomycin related to cutaneous leishmaniasis"" supported by the sentence: ""In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).""?",False, -12550860,Paromomycin related to visceral leishmaniasis,4093,"Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.","Is the triple ""Paromomycin related to visceral leishmaniasis"" supported by the sentence: ""Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.""?",False, -24692385,Paromomycin affects leishmaniasis,4094,"Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.","Is the triple ""Paromomycin affects leishmaniasis"" supported by the sentence: ""Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.""?",False, -23700620,Paromomycin affects visceral leishmaniasis,4095,The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.,"Is the triple ""Paromomycin affects visceral leishmaniasis"" supported by the sentence: ""The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.""?",False, -22567030,Paromomycin affects cutaneous leishmaniasis,4096,"Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.","Is the triple ""Paromomycin affects cutaneous leishmaniasis"" supported by the sentence: ""Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.""?",False, -27729096,Kanamycin related to bacterial infectious disease,4097,The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.,"Is the triple ""Kanamycin related to bacterial infectious disease"" supported by the sentence: ""The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.""?",False, -10553348,Kanamycin related to tuberculosis,4098,Kanamycin in experimental guinea pig tuberculosis.,"Is the triple ""Kanamycin related to tuberculosis"" supported by the sentence: ""Kanamycin in experimental guinea pig tuberculosis.""?",False, -10567002,Kanamycin affects tuberculosis,4099,Effects of kanamycin in experimental tuberculosis of guinea pigs.,"Is the triple ""Kanamycin affects tuberculosis"" supported by the sentence: ""Effects of kanamycin in experimental tuberculosis of guinea pigs.""?",False, -25418796,Vancomycin related to ulcerative colitis,4100,Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.,"Is the triple ""Vancomycin related to ulcerative colitis"" supported by the sentence: ""Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.""?",False, -24528866,Vancomycin related to bacterial infectious disease,4101,"Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.","Is the triple ""Vancomycin related to bacterial infectious disease"" supported by the sentence: ""Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.""?",False, -23989025,Vancomycin related to Inflammation,4102,"The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.""?",False, -22667296,Vancomycin related to arthropathy,4103,"Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).","Is the triple ""Vancomycin related to arthropathy"" supported by the sentence: ""Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).""?",False, -21740759,Vancomycin related to Infection,4104,"Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.""?",False, -20543239,Vancomycin related to hematopoietic and lymphoid system neoplasm,4105,"Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.","Is the triple ""Vancomycin related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.""?",False, -20099844,Vancomycin related to cystic fibrosis,4106,Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.,"Is the triple ""Vancomycin related to cystic fibrosis"" supported by the sentence: ""Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.""?",False, -18717834,Vancomycin related to eye infectious disorder,4107,"MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.","Is the triple ""Vancomycin related to eye infectious disorder"" supported by the sentence: ""MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.""?",False, -18563763,Vancomycin related to staphylococcal pneumonia,4108,No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.,"Is the triple ""Vancomycin related to staphylococcal pneumonia"" supported by the sentence: ""No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.""?",False, -17578296,Vancomycin related to Peptidoglycan,4109,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, -17578296,Vancomycin related to Peptidoglycan,4110,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, -15843803,Vancomycin related to Diabetic Foot,4111,"With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.","Is the triple ""Vancomycin related to Diabetic Foot"" supported by the sentence: ""With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.""?",False, -15502624,Vancomycin related to abscess,4112,Vancomycin and ciprofloxacin levels were inadequate in most abscesses.,"Is the triple ""Vancomycin related to abscess"" supported by the sentence: ""Vancomycin and ciprofloxacin levels were inadequate in most abscesses.""?",False, -15448370,Vancomycin related to obesity disorder,4113,There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).,"Is the triple ""Vancomycin related to obesity disorder"" supported by the sentence: ""There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).""?",False, -15389679,Vancomycin related to osteomyelitis,4114,Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.,"Is the triple ""Vancomycin related to osteomyelitis"" supported by the sentence: ""Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.""?",False, -15008716,Vancomycin related to peritonitis,4115,CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.""?",False, -14607992,Vancomycin related to pneumonia,4116,"Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.","Is the triple ""Vancomycin related to pneumonia"" supported by the sentence: ""Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.""?",False, -14564943,Vancomycin related to gram-positive bacterial infections,4117,"Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.","Is the triple ""Vancomycin related to gram-positive bacterial infections"" supported by the sentence: ""Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.""?",False, -11348824,Vancomycin related to kidney failure,4118,"The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.","Is the triple ""Vancomycin related to kidney failure"" supported by the sentence: ""The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.""?",False, -11195361,Vancomycin related to Neonatal sepsis,4119,"Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.","Is the triple ""Vancomycin related to Neonatal sepsis"" supported by the sentence: ""Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.""?",False, -10946982,Vancomycin related to respiratory tract infectious disorder,4120,This may give linezolid an advantage over vancomycin in certain respiratory infections.,"Is the triple ""Vancomycin related to respiratory tract infectious disorder"" supported by the sentence: ""This may give linezolid an advantage over vancomycin in certain respiratory infections.""?",False, -10225522,Vancomycin related to bacterial infectious disease with sepsis,4121,These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.,"Is the triple ""Vancomycin related to bacterial infectious disease with sepsis"" supported by the sentence: ""These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.""?",False, -9057886,Vancomycin related to nosocomial infection,4122,A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.,"Is the triple ""Vancomycin related to nosocomial infection"" supported by the sentence: ""A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.""?",False, -9057885,Vancomycin related to staphylococcal infection,4123,Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.,"Is the triple ""Vancomycin related to staphylococcal infection"" supported by the sentence: ""Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.""?",False, -8859000,Vancomycin related to endocarditis,4124,"Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.","Is the triple ""Vancomycin related to endocarditis"" supported by the sentence: ""Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.""?",False, -8170422,Vancomycin related to Sepsis,4125,"DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.","Is the triple ""Vancomycin related to Sepsis"" supported by the sentence: ""DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.""?",False, -23445509,Vancomycin related to peritonitis,4126,Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.""?",False, -22719539,Vancomycin related to Infection,4127,"For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).""?",False, -11098147,Vancomycin related to Inflammation,4128,"Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.""?",False, -14094746,Vancomycin coexists with Peptidoglycan,4129,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, -14094746,Vancomycin coexists with Peptidoglycan,4130,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, -7840667,Vancomycin physically interacts with Peptidoglycan,4131,Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.,"Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.""?",False, -7710804,Vancomycin physically interacts with Peptidoglycan,4132,"The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.","Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.""?",False, -26896148,Vancomycin causes endocarditis,4133,Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.,"Is the triple ""Vancomycin causes endocarditis"" supported by the sentence: ""Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.""?",False, -26320414,Vancomycin causes enterocolitis,4134,"Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.","Is the triple ""Vancomycin causes enterocolitis"" supported by the sentence: ""Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.""?",False, -22849619,Vancomycin causes Infection,4135,"Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).","Is the triple ""Vancomycin causes Infection"" supported by the sentence: ""Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).""?",False, -22231760,Vancomycin causes Inflammation,4136,"Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.","Is the triple ""Vancomycin causes Inflammation"" supported by the sentence: ""Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.""?",False, -21632936,Vancomycin causes bacterial infectious disease with sepsis,4137,"Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.","Is the triple ""Vancomycin causes bacterial infectious disease with sepsis"" supported by the sentence: ""Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.""?",False, -18945219,Vancomycin causes peritonitis,4138,A literature search identified one other published report of vancomycin-induced EP.,"Is the triple ""Vancomycin causes peritonitis"" supported by the sentence: ""A literature search identified one other published report of vancomycin-induced EP.""?",False, -15481792,Vancomycin causes skin disorder,4139,We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.,"Is the triple ""Vancomycin causes skin disorder"" supported by the sentence: ""We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.""?",False, -12001625,Vancomycin causes kidney failure,4140,"The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.","Is the triple ""Vancomycin causes kidney failure"" supported by the sentence: ""The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.""?",False, -9570250,Vancomycin causes nosocomial infection,4141,Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.,"Is the triple ""Vancomycin causes nosocomial infection"" supported by the sentence: ""Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.""?",False, -23893373,Vancomycin affects Infection,4142,"CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.""?",False, -21581118,Vancomycin affects Infection,4143,"As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.""?",False, -21291384,Vancomycin affects hematopoietic and lymphoid system neoplasm,4144,"In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.","Is the triple ""Vancomycin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.""?",False, -20283933,Vancomycin affects enterocolitis,4145,"Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.","Is the triple ""Vancomycin affects enterocolitis"" supported by the sentence: ""Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.""?",False, -19879029,Vancomycin affects cystic fibrosis,4146,"Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.","Is the triple ""Vancomycin affects cystic fibrosis"" supported by the sentence: ""Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.""?",False, -16899271,Vancomycin affects Sepsis,4147,"CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.""?",False, -15270589,Vancomycin affects peritonitis,4148,Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.,"Is the triple ""Vancomycin affects peritonitis"" supported by the sentence: ""Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.""?",False, -13735180,Vancomycin affects pneumonia,4149,"Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.","Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.""?",False, -12348278,Vancomycin affects Sepsis,4150,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, -12348277,Vancomycin affects osteomyelitis,4151,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects osteomyelitis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, -12348276,Vancomycin affects endocarditis,4152,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects endocarditis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, -7991855,Vancomycin affects Peptidoglycan,4153,These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.,"Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.""?",False, -7527991,Vancomycin affects pneumonia,4154,The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.,"Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.""?",False, -17707788,Vancomycin affects Peptidoglycan,4155,"In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.","Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.""?",False, -22719533,Vancomycin disrupts Infection,4156,We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.,"Is the triple ""Vancomycin disrupts Infection"" supported by the sentence: ""We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.""?",False, -21036263,Vancomycin disrupts osteomyelitis,4157,"More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.","Is the triple ""Vancomycin disrupts osteomyelitis"" supported by the sentence: ""More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.""?",False, -19924841,Vancomycin disrupts Inflammation,4158,"More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.","Is the triple ""Vancomycin disrupts Inflammation"" supported by the sentence: ""More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.""?",False, -14538194,Vancomycin disrupts enterocolitis,4159,"Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.","Is the triple ""Vancomycin disrupts enterocolitis"" supported by the sentence: ""Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.""?",False, -21888394,Vancomycin prevents bacterial infectious disease,4160,"Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.","Is the triple ""Vancomycin prevents bacterial infectious disease"" supported by the sentence: ""Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.""?",False, -21518539,Vancomycin prevents Infection,4161,Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .,"Is the triple ""Vancomycin prevents Infection"" supported by the sentence: ""Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .""?",False, -21292683,Vancomycin prevents osteomyelitis,4162,"CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.","Is the triple ""Vancomycin prevents osteomyelitis"" supported by the sentence: ""CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.""?",False, -20759704,Vancomycin prevents kidney failure,4163,Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.,"Is the triple ""Vancomycin prevents kidney failure"" supported by the sentence: ""Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.""?",False, -20759520,Vancomycin prevents arthropathy,4164,"Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.","Is the triple ""Vancomycin prevents arthropathy"" supported by the sentence: ""Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.""?",False, -16424860,Vancomycin prevents pneumonia,4165,"Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.","Is the triple ""Vancomycin prevents pneumonia"" supported by the sentence: ""Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.""?",False, -11136130,Vancomycin prevents nosocomial infection,4166,"Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.","Is the triple ""Vancomycin prevents nosocomial infection"" supported by the sentence: ""Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.""?",False, -8520533,Vancomycin prevents peritonitis,4167,The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.,"Is the triple ""Vancomycin prevents peritonitis"" supported by the sentence: ""The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.""?",False, -8203212,Vancomycin prevents endocarditis,4168,"Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.","Is the triple ""Vancomycin prevents endocarditis"" supported by the sentence: ""Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.""?",False, -8170423,Vancomycin prevents Neonatal sepsis,4169,MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.,"Is the triple ""Vancomycin prevents Neonatal sepsis"" supported by the sentence: ""MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.""?",False, -8170420,Vancomycin prevents Sepsis,4170,REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.,"Is the triple ""Vancomycin prevents Sepsis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.""?",False, -7111089,Vancomycin prevents Inflammation,4171,We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.,"Is the triple ""Vancomycin prevents Inflammation"" supported by the sentence: ""We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.""?",False, -25178384,Vancomycin exacerbates Inflammation,4172,"Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.","Is the triple ""Vancomycin exacerbates Inflammation"" supported by the sentence: ""Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.""?",False, -21622859,Vancomycin exacerbates pneumonia,4173,The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.,"Is the triple ""Vancomycin exacerbates pneumonia"" supported by the sentence: ""The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.""?",False, -21314122,Vancomycin predisposes Sepsis,4174,"OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.","Is the triple ""Vancomycin predisposes Sepsis"" supported by the sentence: ""OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.""?",False, -19879549,Vancomycin predisposes kidney failure,4175,"Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.","Is the triple ""Vancomycin predisposes kidney failure"" supported by the sentence: ""Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.""?",False, -18555479,Vancomycin predisposes pneumonia,4176,"Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.","Is the triple ""Vancomycin predisposes pneumonia"" supported by the sentence: ""Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.""?",False, -18327103,Vancomycin predisposes nosocomial infection,4177,"CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.","Is the triple ""Vancomycin predisposes nosocomial infection"" supported by the sentence: ""CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.""?",False, -12689487,Vancomycin predisposes bacterial infectious disease with sepsis,4178,"CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.","Is the triple ""Vancomycin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.""?",False, -12018679,LENOGRASTIM related to plasma cell myeloma,4179,We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.,"Is the triple ""LENOGRASTIM related to plasma cell myeloma"" supported by the sentence: ""We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.""?",False, -24207855,SARGRAMOSTIM related to pulmonary alveolar proteinosis,4180,NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.,"Is the triple ""SARGRAMOSTIM related to pulmonary alveolar proteinosis"" supported by the sentence: ""NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.""?",False, -23712911,SARGRAMOSTIM related to Sepsis,4181,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to Sepsis"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, -23712910,SARGRAMOSTIM related to adult acute respiratory distress syndrome,4182,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to adult acute respiratory distress syndrome"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, -23177848,SARGRAMOSTIM related to Alzheimer disease,4183,An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.,"Is the triple ""SARGRAMOSTIM related to Alzheimer disease"" supported by the sentence: ""An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.""?",False, -16827749,SARGRAMOSTIM related to prostate cancer,4184,Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.,"Is the triple ""SARGRAMOSTIM related to prostate cancer"" supported by the sentence: ""Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.""?",False, -11846978,SARGRAMOSTIM related to Crohn disease,4185,Preliminary studies suggest sargramostim may have activity in Crohn's disease.,"Is the triple ""SARGRAMOSTIM related to Crohn disease"" supported by the sentence: ""Preliminary studies suggest sargramostim may have activity in Crohn's disease.""?",False, -7671811,SARGRAMOSTIM related to HIV infectious disease,4186,"Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.","Is the triple ""SARGRAMOSTIM related to HIV infectious disease"" supported by the sentence: ""Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.""?",False, -7896656,SARGRAMOSTIM prevents neutropenia,4187,Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.,"Is the triple ""SARGRAMOSTIM prevents neutropenia"" supported by the sentence: ""Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.""?",False, -27611311,Filgrastim related to sarcoma,4188,Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.,"Is the triple ""Filgrastim related to sarcoma"" supported by the sentence: ""Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.""?",False, -26602673,Filgrastim related to acute lymphoblastic leukemia,4189,Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.,"Is the triple ""Filgrastim related to acute lymphoblastic leukemia"" supported by the sentence: ""Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.""?",False, -26505391,Filgrastim related to Hodgkins lymphoma,4190,"CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.","Is the triple ""Filgrastim related to Hodgkins lymphoma"" supported by the sentence: ""CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.""?",False, -23038064,Filgrastim related to Infection,4191,"RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.","Is the triple ""Filgrastim related to Infection"" supported by the sentence: ""RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.""?",False, -22749433,Filgrastim related to neoplasm,4192,"Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.","Is the triple ""Filgrastim related to neoplasm"" supported by the sentence: ""Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.""?",False, -19713781,Filgrastim related to lymphoma,4193,A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.,"Is the triple ""Filgrastim related to lymphoma"" supported by the sentence: ""A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.""?",False, -18903615,Filgrastim related to HIV infectious disease,4194,"Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.","Is the triple ""Filgrastim related to HIV infectious disease"" supported by the sentence: ""Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.""?",False, -17402873,Filgrastim related to acute myeloid leukemia,4195,"Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.","Is the triple ""Filgrastim related to acute myeloid leukemia"" supported by the sentence: ""Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.""?",False, -16080456,Filgrastim related to plasma cell myeloma,4196,"Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).","Is the triple ""Filgrastim related to plasma cell myeloma"" supported by the sentence: ""Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).""?",False, -14467347,Filgrastim related to myocardial infarction,4197,"Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.","Is the triple ""Filgrastim related to myocardial infarction"" supported by the sentence: ""Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.""?",False, -13860825,Filgrastim related to small cell lung carcinoma,4198,Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.,"Is the triple ""Filgrastim related to small cell lung carcinoma"" supported by the sentence: ""Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.""?",False, -10253688,Filgrastim related to ovarian cancer,4199,"Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.","Is the triple ""Filgrastim related to ovarian cancer"" supported by the sentence: ""Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.""?",False, -9334871,Filgrastim related to non-small cell lung carcinoma,4200,"A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.","Is the triple ""Filgrastim related to non-small cell lung carcinoma"" supported by the sentence: ""A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.""?",False, -7868897,Filgrastim related to neutropenia,4201,"Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.","Is the triple ""Filgrastim related to neutropenia"" supported by the sentence: ""Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.""?",False, -7775323,Filgrastim related to non-Hodgkin lymphoma,4202,Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.,"Is the triple ""Filgrastim related to non-Hodgkin lymphoma"" supported by the sentence: ""Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.""?",False, -13176527,Filgrastim has part non-Hodgkin lymphoma,4203,Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.,"Is the triple ""Filgrastim has part non-Hodgkin lymphoma"" supported by the sentence: ""Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.""?",False, -27488127,Filgrastim causes acute myeloid leukemia,4204,"The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.","Is the triple ""Filgrastim causes acute myeloid leukemia"" supported by the sentence: ""The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.""?",False, -26596932,Filgrastim causes acute lymphoblastic leukemia,4205,Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.,"Is the triple ""Filgrastim causes acute lymphoblastic leukemia"" supported by the sentence: ""Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.""?",False, -19245347,Filgrastim causes myeloproliferative neoplasm,4206,Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.,"Is the triple ""Filgrastim causes myeloproliferative neoplasm"" supported by the sentence: ""Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.""?",False, -8419399,Filgrastim causes neutropenia,4207,Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.,"Is the triple ""Filgrastim causes neutropenia"" supported by the sentence: ""Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.""?",False, -26496059,Filgrastim affects neutropenia,4208,"The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.","Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.""?",False, -15351355,Filgrastim affects Fever,4209,"Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.","Is the triple ""Filgrastim affects Fever"" supported by the sentence: ""Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.""?",False, -7868413,Filgrastim affects neutropenia,4210,Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.,"Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.""?",False, -9501874,Filgrastim disrupts neutropenia,4211,Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.,"Is the triple ""Filgrastim disrupts neutropenia"" supported by the sentence: ""Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.""?",False, -14309803,Filgrastim prevents non-Hodgkin lymphoma,4212,"The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).","Is the triple ""Filgrastim prevents non-Hodgkin lymphoma"" supported by the sentence: ""The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).""?",False, -7265196,Filgrastim prevents neutropenia,4213,We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.,"Is the triple ""Filgrastim prevents neutropenia"" supported by the sentence: ""We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.""?",False, -16134815,Filgrastim predisposes hematopoietic and lymphoid system neoplasm,4214,BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.,"Is the triple ""Filgrastim predisposes hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.""?",False, -14495646,Filgrastim predisposes neutropenia,4215,"Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.","Is the triple ""Filgrastim predisposes neutropenia"" supported by the sentence: ""Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.""?",False, -12306052,Tibolone affects physiological sexual disorder,4216,"Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.","Is the triple ""Tibolone affects physiological sexual disorder"" supported by the sentence: ""Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.""?",False, -7873396,Tibolone prevents osteoporosis,4217,"In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.","Is the triple ""Tibolone prevents osteoporosis"" supported by the sentence: ""In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.""?",False, -17565484,Cosyntropin affects West syndrome,4218,"TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.","Is the triple ""Cosyntropin affects West syndrome"" supported by the sentence: ""TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.""?",False, -11757081,Cosyntropin disrupts hypertensive disorder,4219,In one child synthetic ACTH was stopped because of arterial hypertension.,"Is the triple ""Cosyntropin disrupts hypertensive disorder"" supported by the sentence: ""In one child synthetic ACTH was stopped because of arterial hypertension.""?",False, -19585114,Corticotropin related to chronic progressive multiple sclerosis,4220,Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.,"Is the triple ""Corticotropin related to chronic progressive multiple sclerosis"" supported by the sentence: ""Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.""?",False, -15839924,Corticotropin related to membranous glomerulonephritis,4221,The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.,"Is the triple ""Corticotropin related to membranous glomerulonephritis"" supported by the sentence: ""The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.""?",False, -10947313,Corticotropin related to polycystic ovary syndrome,4222,"CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.","Is the triple ""Corticotropin related to polycystic ovary syndrome"" supported by the sentence: ""CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.""?",False, -10518316,Corticotropin related to dermatomyositis,4223,Corticotrophin and cortisone therapy in dermatomyositis.,"Is the triple ""Corticotropin related to dermatomyositis"" supported by the sentence: ""Corticotrophin and cortisone therapy in dermatomyositis.""?",False, -10489579,Corticotropin related to epilepsy,4224,[Observations on several cases of epilepsy in children with ACTH and cortisone].,"Is the triple ""Corticotropin related to epilepsy"" supported by the sentence: ""[Observations on several cases of epilepsy in children with ACTH and cortisone].""?",False, -10438408,Corticotropin related to nephrotic syndrome,4225,Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.,"Is the triple ""Corticotropin related to nephrotic syndrome"" supported by the sentence: ""Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.""?",False, -10431205,Corticotropin related to sarcoidosis,4226,[ACTH and cortisone in sarcoidosis; preliminary report].,"Is the triple ""Corticotropin related to sarcoidosis"" supported by the sentence: ""[ACTH and cortisone in sarcoidosis; preliminary report].""?",False, -10427009,Corticotropin related to optic neuritis,4227,Intravenous use of corticotropin in optic neuritis.,"Is the triple ""Corticotropin related to optic neuritis"" supported by the sentence: ""Intravenous use of corticotropin in optic neuritis.""?",False, -9718321,Corticotropin related to rheumatoid arthritis,4228,"ACTH, cortisol and prolactin in active rheumatoid arthritis.","Is the triple ""Corticotropin related to rheumatoid arthritis"" supported by the sentence: ""ACTH, cortisol and prolactin in active rheumatoid arthritis.""?",False, -8496620,Corticotropin related to multiple sclerosis,4229,Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.,"Is the triple ""Corticotropin related to multiple sclerosis"" supported by the sentence: ""Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.""?",False, -7394246,Corticotropin related to West syndrome,4230,ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.,"Is the triple ""Corticotropin related to West syndrome"" supported by the sentence: ""ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.""?",False, -22849896,Corticotropin causes West syndrome,4231,Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.,"Is the triple ""Corticotropin causes West syndrome"" supported by the sentence: ""Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.""?",False, -12436107,Corticotropin causes epilepsy,4232,"The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.","Is the triple ""Corticotropin causes epilepsy"" supported by the sentence: ""The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.""?",False, -11010111,Corticotropin causes rheumatoid arthritis,4233,The natural course of rheumatoid arthritis and the changes induced by ACTH.,"Is the triple ""Corticotropin causes rheumatoid arthritis"" supported by the sentence: ""The natural course of rheumatoid arthritis and the changes induced by ACTH.""?",False, -17565428,Corticotropin affects West syndrome,4234,Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.,"Is the triple ""Corticotropin affects West syndrome"" supported by the sentence: ""Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.""?",False, -15783986,Corticotropin affects multiple sclerosis,4235,"At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.","Is the triple ""Corticotropin affects multiple sclerosis"" supported by the sentence: ""At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.""?",False, -15695412,Corticotropin affects polycystic ovary syndrome,4236,Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.,"Is the triple ""Corticotropin affects polycystic ovary syndrome"" supported by the sentence: ""Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.""?",False, -11427275,Corticotropin affects dermatomyositis,4237,The effect of pituitary adrenocorticotropin in dermatomyositis.,"Is the triple ""Corticotropin affects dermatomyositis"" supported by the sentence: ""The effect of pituitary adrenocorticotropin in dermatomyositis.""?",False, -10737513,Corticotropin affects sarcoidosis,4238,The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).,"Is the triple ""Corticotropin affects sarcoidosis"" supported by the sentence: ""The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).""?",False, -10422766,Corticotropin affects rheumatoid arthritis,4239,On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.,"Is the triple ""Corticotropin affects rheumatoid arthritis"" supported by the sentence: ""On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.""?",False, -9312832,Corticotropin affects epilepsy,4240,"The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).","Is the triple ""Corticotropin affects epilepsy"" supported by the sentence: ""The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).""?",False, -15159690,Corticotropin disrupts epilepsy,4241,AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.,"Is the triple ""Corticotropin disrupts epilepsy"" supported by the sentence: ""AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.""?",False, -27033387,Corticotropin prevents West syndrome,4242,Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.,"Is the triple ""Corticotropin prevents West syndrome"" supported by the sentence: ""Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.""?",False, -10517176,Corticotropin prevents epilepsy,4243,"Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.","Is the triple ""Corticotropin prevents epilepsy"" supported by the sentence: ""Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.""?",False, -23224982,Corticotropin predisposes epilepsy,4244,"The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.","Is the triple ""Corticotropin predisposes epilepsy"" supported by the sentence: ""The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.""?",False, -15800284,Dabigatran etexilate related to atrial fibrillation,4245,"In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.","Is the triple ""Dabigatran etexilate related to atrial fibrillation"" supported by the sentence: ""In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.""?",False, -16972150,Dabigatran etexilate affects stroke disorder,4246,This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.,"Is the triple ""Dabigatran etexilate affects stroke disorder"" supported by the sentence: ""This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.""?",False, -21262475,Dabigatran etexilate prevents thrombophilia due to thrombin defect,4247,Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.,"Is the triple ""Dabigatran etexilate prevents thrombophilia due to thrombin defect"" supported by the sentence: ""Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.""?",False, -19084221,Dabigatran etexilate prevents thrombotic disease,4248,"A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.","Is the triple ""Dabigatran etexilate prevents thrombotic disease"" supported by the sentence: ""A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.""?",False, -14524874,Dabigatran etexilate prevents stroke disorder,4249,"Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.","Is the triple ""Dabigatran etexilate prevents stroke disorder"" supported by the sentence: ""Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.""?",False, -11599698,Dabigatran etexilate prevents Thromboembolism,4250,"A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.","Is the triple ""Dabigatran etexilate prevents Thromboembolism"" supported by the sentence: ""A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.""?",False, -15929248,Dabigatran etexilate predisposes stroke disorder,4251,"Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.","Is the triple ""Dabigatran etexilate predisposes stroke disorder"" supported by the sentence: ""Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.""?",False, -13343476,Dabigatran etexilate predisposes Thromboembolism,4252,"INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.","Is the triple ""Dabigatran etexilate predisposes Thromboembolism"" supported by the sentence: ""INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.""?",False, -10867084,Ximelagatran related to atrial fibrillation,4253,Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.,"Is the triple ""Ximelagatran related to atrial fibrillation"" supported by the sentence: ""Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.""?",False, -12162541,Ximelagatran prevents thrombotic disease,4254,A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.,"Is the triple ""Ximelagatran prevents thrombotic disease"" supported by the sentence: ""A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.""?",False, -9396435,Ximelagatran prevents Thromboembolism,4255,"In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.","Is the triple ""Ximelagatran prevents Thromboembolism"" supported by the sentence: ""In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.""?",False, -13148663,Ximelagatran predisposes Thromboembolism,4256,"OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.","Is the triple ""Ximelagatran predisposes Thromboembolism"" supported by the sentence: ""OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.""?",False, -24220155,Bivalirudin related to Hemorrhage,4257,"CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.""?",False, -23845334,Bivalirudin related to thrombocytopenia,4258,"Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).","Is the triple ""Bivalirudin related to thrombocytopenia"" supported by the sentence: ""Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).""?",False, -21128552,Bivalirudin related to heart disorder,4259,"AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.","Is the triple ""Bivalirudin related to heart disorder"" supported by the sentence: ""AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.""?",False, -16166302,Bivalirudin related to coronary artery disorder,4260,Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.,"Is the triple ""Bivalirudin related to coronary artery disorder"" supported by the sentence: ""Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.""?",False, -9469606,Bivalirudin related to myocardial infarction,4261,"Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.","Is the triple ""Bivalirudin related to myocardial infarction"" supported by the sentence: ""Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.""?",False, -9060136,Bivalirudin related to acute coronary syndrome,4262,Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.,"Is the triple ""Bivalirudin related to acute coronary syndrome"" supported by the sentence: ""Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.""?",False, -21743704,Bivalirudin related to Hemorrhage,4263,"On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.""?",False, -18003165,Bivalirudin related to thrombotic disease,4264,"CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.","Is the triple ""Bivalirudin related to thrombotic disease"" supported by the sentence: ""CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.""?",False, -15575490,Bivalirudin causes myocardial infarction,4265,These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.,"Is the triple ""Bivalirudin causes myocardial infarction"" supported by the sentence: ""These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.""?",False, -10298579,Bivalirudin causes Hemorrhage,4266,"However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).","Is the triple ""Bivalirudin causes Hemorrhage"" supported by the sentence: ""However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).""?",False, -19056194,Bivalirudin affects thrombotic disease,4267,Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.""?",False, -15575489,Bivalirudin affects thrombotic disease,4268,DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).""?",False, -14748514,Bivalirudin affects myocardial infarction,4269,"Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.","Is the triple ""Bivalirudin affects myocardial infarction"" supported by the sentence: ""Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.""?",False, -14318099,Bivalirudin affects Hemorrhage,4270,Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.,"Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.""?",False, -9597163,Bivalirudin affects Hemorrhage,4271,"In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.","Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.""?",False, -19316921,Bivalirudin disrupts myocardial infarction,4272,"CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.","Is the triple ""Bivalirudin disrupts myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.""?",False, -19056195,Bivalirudin disrupts thrombotic disease,4273,"BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.","Is the triple ""Bivalirudin disrupts thrombotic disease"" supported by the sentence: ""BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.""?",False, -13525067,Bivalirudin disrupts acute coronary syndrome,4274,Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.,"Is the triple ""Bivalirudin disrupts acute coronary syndrome"" supported by the sentence: ""Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.""?",False, -13434992,Bivalirudin disrupts Hemorrhage,4275,"Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.","Is the triple ""Bivalirudin disrupts Hemorrhage"" supported by the sentence: ""Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.""?",False, -21793150,Bivalirudin prevents Hemorrhage,4276,Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.,"Is the triple ""Bivalirudin prevents Hemorrhage"" supported by the sentence: ""Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.""?",False, -20637086,Bivalirudin prevents syndromic disease,4277,Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.,"Is the triple ""Bivalirudin prevents syndromic disease"" supported by the sentence: ""Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.""?",False, -17823880,Bivalirudin prevents myocardial infarction,4278,"This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).","Is the triple ""Bivalirudin prevents myocardial infarction"" supported by the sentence: ""This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).""?",False, -10215156,Bivalirudin prevents thrombotic disease,4279,Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.,"Is the triple ""Bivalirudin prevents thrombotic disease"" supported by the sentence: ""Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.""?",False, -22425248,Bivalirudin predisposes Hemorrhage,4280,"Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.","Is the triple ""Bivalirudin predisposes Hemorrhage"" supported by the sentence: ""Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.""?",False, -16276306,Bivalirudin predisposes thrombotic disease,4281,"Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.","Is the triple ""Bivalirudin predisposes thrombotic disease"" supported by the sentence: ""Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.""?",False, -14172527,Bivalirudin predisposes myocardial infarction,4282,A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).,"Is the triple ""Bivalirudin predisposes myocardial infarction"" supported by the sentence: ""A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).""?",False, -17086386,Melagatran disrupts thrombotic disease,4283,"The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.","Is the triple ""Melagatran disrupts thrombotic disease"" supported by the sentence: ""The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.""?",False, -9182682,Lepirudin related to thrombotic disease,4284,"Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.","Is the triple ""Lepirudin related to thrombotic disease"" supported by the sentence: ""Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.""?",False, -27183131,Lepirudin affects thrombotic disease,4285,Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.,"Is the triple ""Lepirudin affects thrombotic disease"" supported by the sentence: ""Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.""?",False, -26612130,Lepirudin disrupts thrombotic disease,4286,Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.,"Is the triple ""Lepirudin disrupts thrombotic disease"" supported by the sentence: ""Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.""?",False, -9038512,Lepirudin prevents thrombotic disease,4287,"Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.","Is the triple ""Lepirudin prevents thrombotic disease"" supported by the sentence: ""Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.""?",False, -24074121,Ripasudil affects Fuchs' endothelial dystrophy,4288,"Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).","Is the triple ""Ripasudil affects Fuchs' endothelial dystrophy"" supported by the sentence: ""Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).""?",False, -23144840,Netarsudil prevents corneal edema,4289,CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.,"Is the triple ""Netarsudil prevents corneal edema"" supported by the sentence: ""CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.""?",False, -21457868,Netarsudil prevents open-angle glaucoma,4290,Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.,"Is the triple ""Netarsudil prevents open-angle glaucoma"" supported by the sentence: ""Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.""?",False, -25249408,Calcitriol related to Hypocalcemia,4291,We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.,"Is the triple ""Calcitriol related to Hypocalcemia"" supported by the sentence: ""We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.""?",False, -24424216,Calcitriol related to Crohn disease,4292,"From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].","Is the triple ""Calcitriol related to Crohn disease"" supported by the sentence: ""From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].""?",False, -23057137,Calcitriol related to acute kidney failure,4293,Production and metabolic clearance of calcitriol in acute renal failure.,"Is the triple ""Calcitriol related to acute kidney failure"" supported by the sentence: ""Production and metabolic clearance of calcitriol in acute renal failure.""?",False, -21048179,Calcitriol related to breast neoplasm,4294,"In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.","Is the triple ""Calcitriol related to breast neoplasm"" supported by the sentence: ""In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.""?",False, -18873537,Calcitriol related to diabetic kidney disease,4295,"The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.","Is the triple ""Calcitriol related to diabetic kidney disease"" supported by the sentence: ""The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.""?",False, -17759117,Calcitriol related to Sepsis,4296,Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.,"Is the triple ""Calcitriol related to Sepsis"" supported by the sentence: ""Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.""?",False, -17014883,Calcitriol related to hypoparathyroidism,4297,We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.,"Is the triple ""Calcitriol related to hypoparathyroidism"" supported by the sentence: ""We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.""?",False, -16783681,Calcitriol related to non-small cell lung carcinoma,4298,A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.,"Is the triple ""Calcitriol related to non-small cell lung carcinoma"" supported by the sentence: ""A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.""?",False, -16670490,Calcitriol related to postmenopausal osteoporosis,4299,Long-term treatment with calcitriol in postmenopausal osteoporosis.,"Is the triple ""Calcitriol related to postmenopausal osteoporosis"" supported by the sentence: ""Long-term treatment with calcitriol in postmenopausal osteoporosis.""?",False, -16084679,Calcitriol related to hypertensive disorder,4300,"AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.","Is the triple ""Calcitriol related to hypertensive disorder"" supported by the sentence: ""AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.""?",False, -15183062,Calcitriol related to type 1 diabetes mellitus,4301,OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.,"Is the triple ""Calcitriol related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.""?",False, -13574949,Calcitriol related to neoplasm,4302,"We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.","Is the triple ""Calcitriol related to neoplasm"" supported by the sentence: ""We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.""?",False, -13228040,Calcitriol related to castration-resistant prostate carcinoma,4303,"Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.","Is the triple ""Calcitriol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.""?",False, -11632117,Calcitriol related to prostate cancer,4304,Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.,"Is the triple ""Calcitriol related to prostate cancer"" supported by the sentence: ""Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.""?",False, -11549262,Calcitriol related to renal osteodystrophy,4305,"In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.","Is the triple ""Calcitriol related to renal osteodystrophy"" supported by the sentence: ""In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.""?",False, -11138207,Calcitriol related to skin basal cell carcinoma,4306,"RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.","Is the triple ""Calcitriol related to skin basal cell carcinoma"" supported by the sentence: ""RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.""?",False, -9056874,Calcitriol related to psoriasis,4307,"Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.","Is the triple ""Calcitriol related to psoriasis"" supported by the sentence: ""Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.""?",False, -8335532,Calcitriol related to chronic kidney disease,4308,This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.,"Is the triple ""Calcitriol related to chronic kidney disease"" supported by the sentence: ""This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.""?",False, -7638906,Calcitriol related to myelodysplastic syndrome,4309,Calcitriol in myelodysplastic syndromes.,"Is the triple ""Calcitriol related to myelodysplastic syndrome"" supported by the sentence: ""Calcitriol in myelodysplastic syndromes.""?",False, -7210521,Calcitriol related to osteoporosis,4310,"To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.","Is the triple ""Calcitriol related to osteoporosis"" supported by the sentence: ""To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.""?",False, -23300761,Calcitriol causes hypoparathyroidism,4311,Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.,"Is the triple ""Calcitriol causes hypoparathyroidism"" supported by the sentence: ""Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.""?",False, -22190855,Calcitriol causes Hypocalcemia,4312,"At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.","Is the triple ""Calcitriol causes Hypocalcemia"" supported by the sentence: ""At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.""?",False, -13672029,Calcitriol causes renal osteodystrophy,4313,"Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.","Is the triple ""Calcitriol causes renal osteodystrophy"" supported by the sentence: ""Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.""?",False, -8610431,Calcitriol causes neoplasm,4314,In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.,"Is the triple ""Calcitriol causes neoplasm"" supported by the sentence: ""In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.""?",False, -26699785,Calcitriol affects myelodysplastic syndrome,4315,"Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.","Is the triple ""Calcitriol affects myelodysplastic syndrome"" supported by the sentence: ""Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.""?",False, -26649101,Calcitriol affects psoriasis,4316,Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.,"Is the triple ""Calcitriol affects psoriasis"" supported by the sentence: ""Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.""?",False, -20118335,Calcitriol affects chronic kidney disease,4317,"A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.","Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.""?",False, -18144364,Calcitriol affects diabetic kidney disease,4318,CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.,"Is the triple ""Calcitriol affects diabetic kidney disease"" supported by the sentence: ""CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.""?",False, -17907580,Calcitriol affects breast neoplasm,4319,In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.,"Is the triple ""Calcitriol affects breast neoplasm"" supported by the sentence: ""In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.""?",False, -15840384,Calcitriol affects skin basal cell carcinoma,4320,Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.,"Is the triple ""Calcitriol affects skin basal cell carcinoma"" supported by the sentence: ""Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.""?",False, -15206874,Calcitriol affects neoplasm,4321,Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.""?",False, -15145405,Calcitriol affects neoplasm,4322,Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.""?",False, -10932246,Calcitriol affects chronic kidney disease,4323,Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.,"Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.""?",False, -9912093,Calcitriol affects prostate cancer,4324,Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.,"Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.""?",False, -9912091,Calcitriol affects prostate cancer,4325,"As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.","Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.""?",False, -26695789,Calcitriol produces renal osteodystrophy,4326,Renal osteodystrophy may be modulated by extrarenal production of calcitriol.,"Is the triple ""Calcitriol produces renal osteodystrophy"" supported by the sentence: ""Renal osteodystrophy may be modulated by extrarenal production of calcitriol.""?",False, -14288417,Calcitriol produces Crohn disease,4327,"Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).","Is the triple ""Calcitriol produces Crohn disease"" supported by the sentence: ""Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).""?",False, -19013737,Calcitriol disrupts chronic kidney disease,4328,"Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.","Is the triple ""Calcitriol disrupts chronic kidney disease"" supported by the sentence: ""Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.""?",False, -17492128,Calcitriol disrupts prostate cancer,4329,"Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).","Is the triple ""Calcitriol disrupts prostate cancer"" supported by the sentence: ""Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).""?",False, -15711853,Calcitriol disrupts neoplasm,4330,"Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.","Is the triple ""Calcitriol disrupts neoplasm"" supported by the sentence: ""Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.""?",False, -23005720,Calcitriol prevents neoplasm,4331,"We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.","Is the triple ""Calcitriol prevents neoplasm"" supported by the sentence: ""We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.""?",False, -22688863,Calcitriol prevents Hypocalcemia,4332,"Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.","Is the triple ""Calcitriol prevents Hypocalcemia"" supported by the sentence: ""Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.""?",False, -18398383,Calcitriol prevents diabetic kidney disease,4333,OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).,"Is the triple ""Calcitriol prevents diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).""?",False, -17492127,Calcitriol prevents prostate cancer,4334,"To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)","Is the triple ""Calcitriol prevents prostate cancer"" supported by the sentence: ""To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)""?",False, -8346486,Calcitriol prevents osteoporosis,4335,Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.,"Is the triple ""Calcitriol prevents osteoporosis"" supported by the sentence: ""Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.""?",False, -8053720,Calcitriol prevents postmenopausal osteoporosis,4336,CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.,"Is the triple ""Calcitriol prevents postmenopausal osteoporosis"" supported by the sentence: ""CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.""?",False, -24886178,Calcitriol exacerbates Sepsis,4337,"Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.","Is the triple ""Calcitriol exacerbates Sepsis"" supported by the sentence: ""Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.""?",False, -18653087,Calcitriol exacerbates hypertensive disorder,4338,"Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.","Is the triple ""Calcitriol exacerbates hypertensive disorder"" supported by the sentence: ""Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.""?",False, -21373396,Calcitriol predisposes chronic kidney disease,4339,"Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.","Is the triple ""Calcitriol predisposes chronic kidney disease"" supported by the sentence: ""Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.""?",False, -17377804,Calcitriol predisposes hypertensive disorder,4340,Calcitriol deficiency is a risk factor for DM and hypertension.,"Is the triple ""Calcitriol predisposes hypertensive disorder"" supported by the sentence: ""Calcitriol deficiency is a risk factor for DM and hypertension.""?",False, -16828204,Calcitriol predisposes osteoporosis,4341,OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.,"Is the triple ""Calcitriol predisposes osteoporosis"" supported by the sentence: ""OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.""?",False, -9760670,Calcitriol predisposes prostate cancer,4342,"Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.","Is the triple ""Calcitriol predisposes prostate cancer"" supported by the sentence: ""Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.""?",False, -26462827,Alfacalcidol related to kidney failure,4343,The use of alfacalcidol in the prevention of bone disease in early renal failure.,"Is the triple ""Alfacalcidol related to kidney failure"" supported by the sentence: ""The use of alfacalcidol in the prevention of bone disease in early renal failure.""?",False, -9037270,Alfacalcidol related to postmenopausal osteoporosis,4344,"We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.","Is the triple ""Alfacalcidol related to postmenopausal osteoporosis"" supported by the sentence: ""We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.""?",False, -7210524,Alfacalcidol related to osteoporosis,4345,"These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.","Is the triple ""Alfacalcidol related to osteoporosis"" supported by the sentence: ""These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.""?",False, -22711685,Alfacalcidol causes osteoporosis,4346,"Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.","Is the triple ""Alfacalcidol causes osteoporosis"" supported by the sentence: ""Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.""?",False, -26635675,Alfacalcidol affects kidney failure,4347,"Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.","Is the triple ""Alfacalcidol affects kidney failure"" supported by the sentence: ""Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.""?",False, -21927698,Alfacalcidol affects myopathy,4348,This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.,"Is the triple ""Alfacalcidol affects myopathy"" supported by the sentence: ""This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.""?",False, -11900508,Alfacalcidol affects postmenopausal osteoporosis,4349,"The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.","Is the triple ""Alfacalcidol affects postmenopausal osteoporosis"" supported by the sentence: ""The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.""?",False, -8505855,Alfacalcidol affects osteoporosis,4350,Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.,"Is the triple ""Alfacalcidol affects osteoporosis"" supported by the sentence: ""Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.""?",False, -20641062,Alfacalcidol disrupts osteoporosis,4351,The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.,"Is the triple ""Alfacalcidol disrupts osteoporosis"" supported by the sentence: ""The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.""?",False, -21927699,Alfacalcidol prevents myopathy,4352,Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.,"Is the triple ""Alfacalcidol prevents myopathy"" supported by the sentence: ""Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.""?",False, -7684744,Alfacalcidol prevents osteoporosis,4353,"There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.","Is the triple ""Alfacalcidol prevents osteoporosis"" supported by the sentence: ""There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.""?",False, -7684734,Alfacalcidol prevents postmenopausal osteoporosis,4354,Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.,"Is the triple ""Alfacalcidol prevents postmenopausal osteoporosis"" supported by the sentence: ""Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.""?",False, -24020567,Cholecalciferol related to male infertility,4355,Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.,"Is the triple ""Cholecalciferol related to male infertility"" supported by the sentence: ""Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.""?",False, -23185349,Cholecalciferol related to ulcerative colitis,4356,Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.,"Is the triple ""Cholecalciferol related to ulcerative colitis"" supported by the sentence: ""Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.""?",False, -22584995,Cholecalciferol related to acute myeloid leukemia,4357,"CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.","Is the triple ""Cholecalciferol related to acute myeloid leukemia"" supported by the sentence: ""CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.""?",False, -21514930,Cholecalciferol related to Infection,4358,"Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.","Is the triple ""Cholecalciferol related to Infection"" supported by the sentence: ""Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.""?",False, -21254434,Cholecalciferol related to depressive disorder,4359,"Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.","Is the triple ""Cholecalciferol related to depressive disorder"" supported by the sentence: ""Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.""?",False, -20389616,Cholecalciferol related to anemia,4360,Proportion of anemia increased by trimester among women with colecalciferol deficiency.,"Is the triple ""Cholecalciferol related to anemia"" supported by the sentence: ""Proportion of anemia increased by trimester among women with colecalciferol deficiency.""?",False, -20190699,Cholecalciferol related to autism spectrum disorder,4361,Untangling the most probable role for vitamin D3 in autism.,"Is the triple ""Cholecalciferol related to autism spectrum disorder"" supported by the sentence: ""Untangling the most probable role for vitamin D3 in autism.""?",False, -19639056,Cholecalciferol related to pulmonary tuberculosis,4362,Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.,"Is the triple ""Cholecalciferol related to pulmonary tuberculosis"" supported by the sentence: ""Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.""?",False, -18980881,Cholecalciferol related to chronic obstructive pulmonary disease,4363,"These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.","Is the triple ""Cholecalciferol related to chronic obstructive pulmonary disease"" supported by the sentence: ""These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.""?",False, -18889413,Cholecalciferol related to polycystic ovary syndrome,4364,Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?,"Is the triple ""Cholecalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?""?",False, -18830431,Cholecalciferol related to prostate cancer,4365,"Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.","Is the triple ""Cholecalciferol related to prostate cancer"" supported by the sentence: ""Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.""?",False, -18776998,Cholecalciferol related to epilepsy,4366,"These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.","Is the triple ""Cholecalciferol related to epilepsy"" supported by the sentence: ""These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.""?",False, -18009382,Cholecalciferol related to type 1 diabetes mellitus,4367,Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.,"Is the triple ""Cholecalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.""?",False, -17581366,Cholecalciferol related to vitamin D deficiency,4368,The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.,"Is the triple ""Cholecalciferol related to vitamin D deficiency"" supported by the sentence: ""The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.""?",False, -17374616,Cholecalciferol related to type 2 diabetes mellitus,4369,METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.,"Is the triple ""Cholecalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.""?",False, -17169513,Cholecalciferol related to Parkinson disease,4370,CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.,"Is the triple ""Cholecalciferol related to Parkinson disease"" supported by the sentence: ""CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.""?",False, -17054911,Cholecalciferol related to tuberculosis,4371,Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.,"Is the triple ""Cholecalciferol related to tuberculosis"" supported by the sentence: ""Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.""?",False, -16909919,Cholecalciferol related to inflammatory bowel disease,4372,Vitamin D3 has been considered a viable adjunctive therapy in IBD.,"Is the triple ""Cholecalciferol related to inflammatory bowel disease"" supported by the sentence: ""Vitamin D3 has been considered a viable adjunctive therapy in IBD.""?",False, -16219443,"Cholecalciferol related to dermatitis, atopic",4373,Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.,"Is the triple ""Cholecalciferol related to dermatitis, atopic"" supported by the sentence: ""Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.""?",False, -16115730,Cholecalciferol related to cardiovascular disorder,4374,Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.,"Is the triple ""Cholecalciferol related to cardiovascular disorder"" supported by the sentence: ""Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.""?",False, -15133291,Cholecalciferol related to Marchiafava-Bignami disease,4375,"Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.","Is the triple ""Cholecalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.""?",False, -14512631,Cholecalciferol related to hyperparathyroidism,4376,Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.,"Is the triple ""Cholecalciferol related to hyperparathyroidism"" supported by the sentence: ""Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.""?",False, -13680137,Cholecalciferol related to multiple sclerosis,4377,"Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.","Is the triple ""Cholecalciferol related to multiple sclerosis"" supported by the sentence: ""Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.""?",False, -13562951,Cholecalciferol related to metabolic syndrome X,4378,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to metabolic syndrome X"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, -13562949,Cholecalciferol related to obesity disorder,4379,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to obesity disorder"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, -13035326,Cholecalciferol related to bone fracture,4380,Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.,"Is the triple ""Cholecalciferol related to bone fracture"" supported by the sentence: ""Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.""?",False, -11935565,Cholecalciferol related to osteoporosis,4381,"The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.","Is the triple ""Cholecalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.""?",False, -11152529,Cholecalciferol related to diabetes mellitus,4382,"Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.","Is the triple ""Cholecalciferol related to diabetes mellitus"" supported by the sentence: ""Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.""?",False, -10386853,Cholecalciferol related to Crohn disease,4383,OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.,"Is the triple ""Cholecalciferol related to Crohn disease"" supported by the sentence: ""OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.""?",False, -9703967,Cholecalciferol related to melanoma,4384,"As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.","Is the triple ""Cholecalciferol related to melanoma"" supported by the sentence: ""As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.""?",False, -9414232,Cholecalciferol related to psoriasis,4385,Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.,"Is the triple ""Cholecalciferol related to psoriasis"" supported by the sentence: ""Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.""?",False, -8798994,Cholecalciferol related to hip fracture,4386,"Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.","Is the triple ""Cholecalciferol related to hip fracture"" supported by the sentence: ""Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.""?",False, -20878953,Cholecalciferol causes polycystic ovary syndrome,4387,"Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.","Is the triple ""Cholecalciferol causes polycystic ovary syndrome"" supported by the sentence: ""Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.""?",False, -20469671,Cholecalciferol causes tuberculosis,4388,Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.,"Is the triple ""Cholecalciferol causes tuberculosis"" supported by the sentence: ""Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.""?",False, -20417553,Cholecalciferol causes psoriasis,4389,There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.,"Is the triple ""Cholecalciferol causes psoriasis"" supported by the sentence: ""There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.""?",False, -19411734,"Cholecalciferol causes dermatitis, atopic",4390,"In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.","Is the triple ""Cholecalciferol causes dermatitis, atopic"" supported by the sentence: ""In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.""?",False, -17854537,Cholecalciferol causes neoplasm,4391,"Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.","Is the triple ""Cholecalciferol causes neoplasm"" supported by the sentence: ""Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.""?",False, -15944158,Cholecalciferol causes vitamin D deficiency,4392,"Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.","Is the triple ""Cholecalciferol causes vitamin D deficiency"" supported by the sentence: ""Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.""?",False, -13998286,Cholecalciferol causes depressive disorder,4393,"Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.","Is the triple ""Cholecalciferol causes depressive disorder"" supported by the sentence: ""Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.""?",False, -27560876,Cholecalciferol affects prostate cancer,4394,Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.,"Is the triple ""Cholecalciferol affects prostate cancer"" supported by the sentence: ""Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.""?",False, -22640117,Cholecalciferol affects severe acute respiratory syndrome,4395,Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?,"Is the triple ""Cholecalciferol affects severe acute respiratory syndrome"" supported by the sentence: ""Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?""?",False, -21843529,Cholecalciferol affects Pregnancy,4396,"Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.""?",False, -21703950,Cholecalciferol affects Marchiafava-Bignami disease,4397,"VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.","Is the triple ""Cholecalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.""?",False, -20945952,Cholecalciferol affects type 2 diabetes mellitus,4398,Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.,"Is the triple ""Cholecalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.""?",False, -20733345,Cholecalciferol affects epilepsy,4399,"Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.","Is the triple ""Cholecalciferol affects epilepsy"" supported by the sentence: ""Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.""?",False, -20612106,Cholecalciferol affects Cognitive impairment,4400,Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.,"Is the triple ""Cholecalciferol affects Cognitive impairment"" supported by the sentence: ""Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.""?",False, -19925618,Cholecalciferol affects asthma,4401,"METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.","Is the triple ""Cholecalciferol affects asthma"" supported by the sentence: ""METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.""?",False, -19815601,Cholecalciferol affects ulcerative colitis,4402,The effect of vitamin D3 on UC disease activity is still unclear.,"Is the triple ""Cholecalciferol affects ulcerative colitis"" supported by the sentence: ""The effect of vitamin D3 on UC disease activity is still unclear.""?",False, -19556148,Cholecalciferol affects neoplasm,4403,"In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.""?",False, -19132727,Cholecalciferol affects obesity disorder,4404,Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.,"Is the triple ""Cholecalciferol affects obesity disorder"" supported by the sentence: ""Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.""?",False, -18122364,Cholecalciferol affects metabolic syndrome X,4405,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects metabolic syndrome X"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, -18122363,Cholecalciferol affects cardiovascular disorder,4406,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects cardiovascular disorder"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, -17715748,Cholecalciferol affects hip fracture,4407,"Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.","Is the triple ""Cholecalciferol affects hip fracture"" supported by the sentence: ""Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.""?",False, -17674517,Cholecalciferol affects Pregnancy,4408,"OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.""?",False, -17585577,Cholecalciferol affects depressive disorder,4409,"It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.","Is the triple ""Cholecalciferol affects depressive disorder"" supported by the sentence: ""It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.""?",False, -17451551,Cholecalciferol affects neoplasm,4410,"Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.""?",False, -16299943,Cholecalciferol affects polycystic ovary syndrome,4411,"The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).","Is the triple ""Cholecalciferol affects polycystic ovary syndrome"" supported by the sentence: ""The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).""?",False, -16007821,Cholecalciferol affects psoriasis,4412,Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.,"Is the triple ""Cholecalciferol affects psoriasis"" supported by the sentence: ""Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.""?",False, -15977971,Cholecalciferol affects melanoma,4413,"CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.","Is the triple ""Cholecalciferol affects melanoma"" supported by the sentence: ""CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.""?",False, -15944152,Cholecalciferol affects osteoporosis,4414,[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].,"Is the triple ""Cholecalciferol affects osteoporosis"" supported by the sentence: ""[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].""?",False, -15393278,Cholecalciferol affects chronic obstructive pulmonary disease,4415,"Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.","Is the triple ""Cholecalciferol affects chronic obstructive pulmonary disease"" supported by the sentence: ""Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.""?",False, -15170889,Cholecalciferol affects multiple sclerosis,4416,The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.,"Is the triple ""Cholecalciferol affects multiple sclerosis"" supported by the sentence: ""The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.""?",False, -13518388,Cholecalciferol affects bone fracture,4417,[Latest evidence on the suppressive effect of active vitamin D3 on fractures].,"Is the triple ""Cholecalciferol affects bone fracture"" supported by the sentence: ""[Latest evidence on the suppressive effect of active vitamin D3 on fractures].""?",False, -21045274,Cholecalciferol produces Marchiafava-Bignami disease,4418,"CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.","Is the triple ""Cholecalciferol produces Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.""?",False, -17840044,Cholecalciferol produces inflammatory bowel disease,4419,"The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.","Is the triple ""Cholecalciferol produces inflammatory bowel disease"" supported by the sentence: ""The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.""?",False, -20733344,Cholecalciferol disrupts epilepsy,4420,Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.,"Is the triple ""Cholecalciferol disrupts epilepsy"" supported by the sentence: ""Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.""?",False, -19044664,Cholecalciferol disrupts AIDS,4421,Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.,"Is the triple ""Cholecalciferol disrupts AIDS"" supported by the sentence: ""Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.""?",False, -15558469,Cholecalciferol disrupts HIV infectious disease,4422,"Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.","Is the triple ""Cholecalciferol disrupts HIV infectious disease"" supported by the sentence: ""Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.""?",False, -14834931,Cholecalciferol disrupts neoplasm,4423,"Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.","Is the triple ""Cholecalciferol disrupts neoplasm"" supported by the sentence: ""Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.""?",False, -14617748,Cholecalciferol disrupts multiple sclerosis,4424,"Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.","Is the triple ""Cholecalciferol disrupts multiple sclerosis"" supported by the sentence: ""Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.""?",False, -14491908,Cholecalciferol disrupts vitamin D deficiency,4425,"Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.","Is the triple ""Cholecalciferol disrupts vitamin D deficiency"" supported by the sentence: ""Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.""?",False, -11194374,Cholecalciferol disrupts Marchiafava-Bignami disease,4426,Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.,"Is the triple ""Cholecalciferol disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.""?",False, -25419746,Cholecalciferol prevents Infection,4427,This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.,"Is the triple ""Cholecalciferol prevents Infection"" supported by the sentence: ""This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.""?",False, -23552226,Cholecalciferol prevents type 1 diabetes mellitus,4428,Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?,"Is the triple ""Cholecalciferol prevents type 1 diabetes mellitus"" supported by the sentence: ""Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?""?",False, -23324302,Cholecalciferol prevents ulcerative colitis,4429,CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.,"Is the triple ""Cholecalciferol prevents ulcerative colitis"" supported by the sentence: ""CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.""?",False, -22418643,Cholecalciferol prevents chronic obstructive pulmonary disease,4430,"MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).","Is the triple ""Cholecalciferol prevents chronic obstructive pulmonary disease"" supported by the sentence: ""MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).""?",False, -22340834,Cholecalciferol prevents depressive disorder,4431,These findings do not support the use of vitamin D3 in adults to prevent depression.,"Is the triple ""Cholecalciferol prevents depressive disorder"" supported by the sentence: ""These findings do not support the use of vitamin D3 in adults to prevent depression.""?",False, -20959064,Cholecalciferol prevents postmenopausal osteoporosis,4432,"Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?","Is the triple ""Cholecalciferol prevents postmenopausal osteoporosis"" supported by the sentence: ""Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?""?",False, -20699168,Cholecalciferol prevents cardiovascular disorder,4433,"Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.","Is the triple ""Cholecalciferol prevents cardiovascular disorder"" supported by the sentence: ""Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.""?",False, -19389521,Cholecalciferol prevents epilepsy,4434,"Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.","Is the triple ""Cholecalciferol prevents epilepsy"" supported by the sentence: ""Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.""?",False, -18282049,Cholecalciferol prevents inherited lipid metabolism disorder,4435,"Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.","Is the triple ""Cholecalciferol prevents inherited lipid metabolism disorder"" supported by the sentence: ""Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.""?",False, -17951280,Cholecalciferol prevents anemia,4436,VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.,"Is the triple ""Cholecalciferol prevents anemia"" supported by the sentence: ""VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.""?",False, -17701830,Cholecalciferol prevents influenza,4437,[Does vitamin D3 fail to protect against influenza after all?].,"Is the triple ""Cholecalciferol prevents influenza"" supported by the sentence: ""[Does vitamin D3 fail to protect against influenza after all?].""?",False, -15773595,Cholecalciferol prevents neoplasm,4438,[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].,"Is the triple ""Cholecalciferol prevents neoplasm"" supported by the sentence: ""[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].""?",False, -15663430,Cholecalciferol prevents diabetes mellitus,4439,"There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.","Is the triple ""Cholecalciferol prevents diabetes mellitus"" supported by the sentence: ""There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.""?",False, -12943427,Cholecalciferol prevents vitamin D deficiency,4440,"The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.","Is the triple ""Cholecalciferol prevents vitamin D deficiency"" supported by the sentence: ""The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.""?",False, -11194373,Cholecalciferol prevents osteoporosis,4441,"The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.","Is the triple ""Cholecalciferol prevents osteoporosis"" supported by the sentence: ""The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.""?",False, -11017561,Cholecalciferol prevents Marchiafava-Bignami disease,4442,Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.,"Is the triple ""Cholecalciferol prevents Marchiafava-Bignami disease"" supported by the sentence: ""Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.""?",False, -10503621,Cholecalciferol prevents bone fracture,4443,CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.,"Is the triple ""Cholecalciferol prevents bone fracture"" supported by the sentence: ""CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.""?",False, -9458588,Cholecalciferol prevents hip fracture,4444,We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.,"Is the triple ""Cholecalciferol prevents hip fracture"" supported by the sentence: ""We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.""?",False, -21072124,Cholecalciferol predisposes metabolic syndrome X,4445,"Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.","Is the triple ""Cholecalciferol predisposes metabolic syndrome X"" supported by the sentence: ""Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.""?",False, -18104348,Cholecalciferol predisposes colorectal neoplasm,4446,These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.,"Is the triple ""Cholecalciferol predisposes colorectal neoplasm"" supported by the sentence: ""These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.""?",False, -17901013,Cholecalciferol predisposes bone fracture,4447,"Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.","Is the triple ""Cholecalciferol predisposes bone fracture"" supported by the sentence: ""Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.""?",False, -17714481,Cholecalciferol predisposes asthma,4448,"Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.","Is the triple ""Cholecalciferol predisposes asthma"" supported by the sentence: ""Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.""?",False, -17184810,Cholecalciferol predisposes multiple sclerosis,4449,"There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.","Is the triple ""Cholecalciferol predisposes multiple sclerosis"" supported by the sentence: ""There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.""?",False, -15110409,Cholecalciferol predisposes vitamin D deficiency,4450,Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.,"Is the triple ""Cholecalciferol predisposes vitamin D deficiency"" supported by the sentence: ""Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.""?",False, -13562954,Cholecalciferol predisposes type 2 diabetes mellitus,4451,"In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.","Is the triple ""Cholecalciferol predisposes type 2 diabetes mellitus"" supported by the sentence: ""In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.""?",False, -9524358,Cholecalciferol predisposes hip fracture,4452,"Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.","Is the triple ""Cholecalciferol predisposes hip fracture"" supported by the sentence: ""Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.""?",False, -9314384,Cholecalciferol predisposes Marchiafava-Bignami disease,4453,"Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.","Is the triple ""Cholecalciferol predisposes Marchiafava-Bignami disease"" supported by the sentence: ""Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.""?",False, -27330803,Ergocalciferol related to Familial hypophosphatemia,4454,Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.,"Is the triple ""Ergocalciferol related to Familial hypophosphatemia"" supported by the sentence: ""Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.""?",False, -26089502,Ergocalciferol related to osteogenesis imperfecta,4455,Vitamin D and related research in osteogenesis imperfecta.,"Is the triple ""Ergocalciferol related to osteogenesis imperfecta"" supported by the sentence: ""Vitamin D and related research in osteogenesis imperfecta.""?",False, -22199149,Ergocalciferol related to Hypocalcemia,4456,Hypocalcemia may be associated with imbalanced VD and PTH levels.,"Is the triple ""Ergocalciferol related to Hypocalcemia"" supported by the sentence: ""Hypocalcemia may be associated with imbalanced VD and PTH levels.""?",False, -22194600,Ergocalciferol related to severe acute respiratory syndrome,4457,"Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.","Is the triple ""Ergocalciferol related to severe acute respiratory syndrome"" supported by the sentence: ""Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.""?",False, -21840711,Ergocalciferol related to castration-resistant prostate carcinoma,4458,"Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.","Is the triple ""Ergocalciferol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.""?",False, -21543726,Ergocalciferol related to sarcopenia,4459,"Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.","Is the triple ""Ergocalciferol related to sarcopenia"" supported by the sentence: ""Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.""?",False, -21516783,Ergocalciferol related to non-alcoholic fatty liver disease,4460,"Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.","Is the triple ""Ergocalciferol related to non-alcoholic fatty liver disease"" supported by the sentence: ""Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.""?",False, -21478252,Ergocalciferol related to bone fracture,4461,"Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.","Is the triple ""Ergocalciferol related to bone fracture"" supported by the sentence: ""Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.""?",False, -21128214,Ergocalciferol related to bone Paget disease,4462,Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.,"Is the triple ""Ergocalciferol related to bone Paget disease"" supported by the sentence: ""Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.""?",False, -20256197,Ergocalciferol related to restless legs syndrome,4463,"After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).","Is the triple ""Ergocalciferol related to restless legs syndrome"" supported by the sentence: ""After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).""?",False, -19853448,Ergocalciferol related to neuralgia,4464,This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.,"Is the triple ""Ergocalciferol related to neuralgia"" supported by the sentence: ""This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.""?",False, -19595978,Ergocalciferol related to hepatitis C virus infection,4465,BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.,"Is the triple ""Ergocalciferol related to hepatitis C virus infection"" supported by the sentence: ""BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.""?",False, -19221334,Ergocalciferol related to spinal cord injury,4466,"Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.","Is the triple ""Ergocalciferol related to spinal cord injury"" supported by the sentence: ""Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.""?",False, -18303138,Ergocalciferol related to optic neuritis,4467,"The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.","Is the triple ""Ergocalciferol related to optic neuritis"" supported by the sentence: ""The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.""?",False, -17457750,Ergocalciferol related to migraine disorder,4468,"CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.","Is the triple ""Ergocalciferol related to migraine disorder"" supported by the sentence: ""CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.""?",False, -17248671,Ergocalciferol related to diffuse alopecia areata,4469,"There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.","Is the triple ""Ergocalciferol related to diffuse alopecia areata"" supported by the sentence: ""There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.""?",False, -16231683,Ergocalciferol related to chronic hepatitis C virus infection,4470,Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.,"Is the triple ""Ergocalciferol related to chronic hepatitis C virus infection"" supported by the sentence: ""Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.""?",False, -16050991,Ergocalciferol related to lung neoplasm,4471,"In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.","Is the triple ""Ergocalciferol related to lung neoplasm"" supported by the sentence: ""In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.""?",False, -15954794,Ergocalciferol related to femoral neck fracture,4472,Spontaneous femoral neck fracture associated with a low serum level of vitamin D.,"Is the triple ""Ergocalciferol related to femoral neck fracture"" supported by the sentence: ""Spontaneous femoral neck fracture associated with a low serum level of vitamin D.""?",False, -15739454,Ergocalciferol related to diabetic neuropathy,4473,Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.,"Is the triple ""Ergocalciferol related to diabetic neuropathy"" supported by the sentence: ""Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.""?",False, -15603622,Ergocalciferol related to HIV infectious disease,4474,Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.,"Is the triple ""Ergocalciferol related to HIV infectious disease"" supported by the sentence: ""Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.""?",False, -15306422,Ergocalciferol related to blood coagulation disease,4475,"Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.","Is the triple ""Ergocalciferol related to blood coagulation disease"" supported by the sentence: ""Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.""?",False, -15165807,Ergocalciferol related to postmenopausal osteoporosis,4476,Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.,"Is the triple ""Ergocalciferol related to postmenopausal osteoporosis"" supported by the sentence: ""Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.""?",False, -14949967,Ergocalciferol related to Premature birth,4477,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to Premature birth"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, -14949966,Ergocalciferol related to gestational diabetes,4478,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to gestational diabetes"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, -14870236,Ergocalciferol related to chronic renal failure syndrome,4479,[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].,"Is the triple ""Ergocalciferol related to chronic renal failure syndrome"" supported by the sentence: ""[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].""?",False, -14594285,Ergocalciferol related to colorectal neoplasm,4480,"Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.","Is the triple ""Ergocalciferol related to colorectal neoplasm"" supported by the sentence: ""Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.""?",False, -14321159,Ergocalciferol related to asthma,4481,"Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.","Is the triple ""Ergocalciferol related to asthma"" supported by the sentence: ""Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.""?",False, -13975664,Ergocalciferol related to cutaneous lupus erythematosus,4482,Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.,"Is the triple ""Ergocalciferol related to cutaneous lupus erythematosus"" supported by the sentence: ""Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.""?",False, -13939480,Ergocalciferol related to mood disorder,4483,This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.,"Is the triple ""Ergocalciferol related to mood disorder"" supported by the sentence: ""This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.""?",False, -13895667,Ergocalciferol related to sudden cardiac arrest,4484,OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).,"Is the triple ""Ergocalciferol related to sudden cardiac arrest"" supported by the sentence: ""OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).""?",False, -13383363,Ergocalciferol related to sickle cell anemia,4485,The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.,"Is the triple ""Ergocalciferol related to sickle cell anemia"" supported by the sentence: ""The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.""?",False, -13199782,Ergocalciferol related to Alzheimer disease,4486,"Consequently, this study provides evidence for a possible link between AD and vitamin D.","Is the triple ""Ergocalciferol related to Alzheimer disease"" supported by the sentence: ""Consequently, this study provides evidence for a possible link between AD and vitamin D.""?",False, -12834035,Ergocalciferol related to inflammatory bowel disease,4487,Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.,"Is the triple ""Ergocalciferol related to inflammatory bowel disease"" supported by the sentence: ""Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.""?",False, -12803681,Ergocalciferol related to Insulin resistance,4488,We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.,"Is the triple ""Ergocalciferol related to Insulin resistance"" supported by the sentence: ""We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.""?",False, -12377378,Ergocalciferol related to non-Hodgkin lymphoma,4489,CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.,"Is the triple ""Ergocalciferol related to non-Hodgkin lymphoma"" supported by the sentence: ""CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.""?",False, -12131992,Ergocalciferol related to primary hyperparathyroidism,4490,"Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.","Is the triple ""Ergocalciferol related to primary hyperparathyroidism"" supported by the sentence: ""Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.""?",False, -11979233,Ergocalciferol related to leukemia,4491,Vitamin D compounds in leukemia.,"Is the triple ""Ergocalciferol related to leukemia"" supported by the sentence: ""Vitamin D compounds in leukemia.""?",False, -11933002,Ergocalciferol related to Pain,4492,"CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.","Is the triple ""Ergocalciferol related to Pain"" supported by the sentence: ""CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.""?",False, -11653558,Ergocalciferol related to melanoma,4493,The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.,"Is the triple ""Ergocalciferol related to melanoma"" supported by the sentence: ""The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.""?",False, -11434397,Ergocalciferol related to type 1 diabetes mellitus,4494,"Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.","Is the triple ""Ergocalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.""?",False, -11002964,Ergocalciferol related to pulmonary tuberculosis,4495,[Effect of vitamin D2 in pulmonary tuberculosis].,"Is the triple ""Ergocalciferol related to pulmonary tuberculosis"" supported by the sentence: ""[Effect of vitamin D2 in pulmonary tuberculosis].""?",False, -10894479,Ergocalciferol related to Crohn disease,4496,"A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.","Is the triple ""Ergocalciferol related to Crohn disease"" supported by the sentence: ""A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.""?",False, -10768947,Ergocalciferol related to hip fracture,4497,BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.,"Is the triple ""Ergocalciferol related to hip fracture"" supported by the sentence: ""BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.""?",False, -10183383,Ergocalciferol related to Marchiafava-Bignami disease,4498,"Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.","Is the triple ""Ergocalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.""?",False, -10168534,Ergocalciferol related to tuberculosis,4499,"Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.","Is the triple ""Ergocalciferol related to tuberculosis"" supported by the sentence: ""Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.""?",False, -10066878,Ergocalciferol related to lymphoma,4500,"However, the cellular source of the vitamin D hormone in lymphomas remains unclear.","Is the triple ""Ergocalciferol related to lymphoma"" supported by the sentence: ""However, the cellular source of the vitamin D hormone in lymphomas remains unclear.""?",False, -9770434,Ergocalciferol related to neoplasm,4501,"On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.","Is the triple ""Ergocalciferol related to neoplasm"" supported by the sentence: ""On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.""?",False, -9499640,Ergocalciferol related to hypoparathyroidism,4502,The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.,"Is the triple ""Ergocalciferol related to hypoparathyroidism"" supported by the sentence: ""The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.""?",False, -9487308,Ergocalciferol related to myocardial ischemia,4503,Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).,"Is the triple ""Ergocalciferol related to myocardial ischemia"" supported by the sentence: ""Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).""?",False, -9462983,Ergocalciferol related to ulcerative colitis,4504,Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.,"Is the triple ""Ergocalciferol related to ulcerative colitis"" supported by the sentence: ""Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.""?",False, -9176947,Ergocalciferol related to psoriasis,4505,[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].,"Is the triple ""Ergocalciferol related to psoriasis"" supported by the sentence: ""[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].""?",False, -9137351,Ergocalciferol related to nutritional disorder,4506,"RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.","Is the triple ""Ergocalciferol related to nutritional disorder"" supported by the sentence: ""RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.""?",False, -8792180,Ergocalciferol related to type 2 diabetes mellitus,4507,Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.,"Is the triple ""Ergocalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.""?",False, -8116213,Ergocalciferol related to obesity disorder,4508,These data suggest that low vitamin D may be associated with obesity per se.,"Is the triple ""Ergocalciferol related to obesity disorder"" supported by the sentence: ""These data suggest that low vitamin D may be associated with obesity per se.""?",False, -8093753,Ergocalciferol related to vitamin D deficiency,4509,The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.,"Is the triple ""Ergocalciferol related to vitamin D deficiency"" supported by the sentence: ""The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.""?",False, -8061037,Ergocalciferol related to multiple sclerosis,4510,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to multiple sclerosis"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, -8061036,Ergocalciferol related to diabetes mellitus,4511,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to diabetes mellitus"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, -7613246,Ergocalciferol related to osteoporosis,4512,The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.,"Is the triple ""Ergocalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.""?",False, -7587226,Ergocalciferol related to polycystic ovary syndrome,4513,Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.,"Is the triple ""Ergocalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.""?",False, -7252642,Ergocalciferol related to prostate cancer,4514,"Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.","Is the triple ""Ergocalciferol related to prostate cancer"" supported by the sentence: ""Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.""?",False, -26403196,Ergocalciferol causes primary hyperparathyroidism,4515,Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.,"Is the triple ""Ergocalciferol causes primary hyperparathyroidism"" supported by the sentence: ""Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.""?",False, -25624374,Ergocalciferol causes leukemia,4516,Reversibility of vitamin D-induced human leukemia cell-line maturation.,"Is the triple ""Ergocalciferol causes leukemia"" supported by the sentence: ""Reversibility of vitamin D-induced human leukemia cell-line maturation.""?",False, -25513025,Ergocalciferol causes restless legs syndrome,4517,We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.,"Is the triple ""Ergocalciferol causes restless legs syndrome"" supported by the sentence: ""We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.""?",False, -25147512,Ergocalciferol causes sarcopenia,4518,"To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.","Is the triple ""Ergocalciferol causes sarcopenia"" supported by the sentence: ""To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.""?",False, -21420546,Ergocalciferol causes diabetic neuropathy,4519,"Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).","Is the triple ""Ergocalciferol causes diabetic neuropathy"" supported by the sentence: ""Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).""?",False, -21344725,Ergocalciferol causes diffuse alopecia areata,4520,"This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.","Is the triple ""Ergocalciferol causes diffuse alopecia areata"" supported by the sentence: ""This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.""?",False, -19221130,Ergocalciferol causes non-alcoholic fatty liver disease,4521,"Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.","Is the triple ""Ergocalciferol causes non-alcoholic fatty liver disease"" supported by the sentence: ""Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.""?",False, -19022139,Ergocalciferol causes gestational diabetes,4522,BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).,"Is the triple ""Ergocalciferol causes gestational diabetes"" supported by the sentence: ""BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).""?",False, -18967408,Ergocalciferol causes polycystic ovary syndrome,4523,"BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.","Is the triple ""Ergocalciferol causes polycystic ovary syndrome"" supported by the sentence: ""BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.""?",False, -18875338,Ergocalciferol causes psoriasis,4524,"The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.","Is the triple ""Ergocalciferol causes psoriasis"" supported by the sentence: ""The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.""?",False, -18041148,Ergocalciferol causes Crohn disease,4525,"Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.","Is the triple ""Ergocalciferol causes Crohn disease"" supported by the sentence: ""Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.""?",False, -16369420,Ergocalciferol causes neoplasm,4526,"Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.","Is the triple ""Ergocalciferol causes neoplasm"" supported by the sentence: ""Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.""?",False, -16017645,Ergocalciferol causes obesity disorder,4527,This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.,"Is the triple ""Ergocalciferol causes obesity disorder"" supported by the sentence: ""This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.""?",False, -15862130,Ergocalciferol causes type 2 diabetes mellitus,4528,"CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.","Is the triple ""Ergocalciferol causes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.""?",False, -15179909,Ergocalciferol causes asthma,4529,"OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.","Is the triple ""Ergocalciferol causes asthma"" supported by the sentence: ""OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.""?",False, -14594790,Ergocalciferol causes Insulin resistance,4530,"In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.","Is the triple ""Ergocalciferol causes Insulin resistance"" supported by the sentence: ""In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.""?",False, -14004176,Ergocalciferol causes Pain,4531,The independent role of vitamin D in the etiology of pain remains controversial.,"Is the triple ""Ergocalciferol causes Pain"" supported by the sentence: ""The independent role of vitamin D in the etiology of pain remains controversial.""?",False, -12191251,Ergocalciferol causes osteoporosis,4532,"We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.","Is the triple ""Ergocalciferol causes osteoporosis"" supported by the sentence: ""We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.""?",False, -11612180,Ergocalciferol causes colorectal neoplasm,4533,There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.,"Is the triple ""Ergocalciferol causes colorectal neoplasm"" supported by the sentence: ""There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.""?",False, -11557471,Ergocalciferol causes vitamin D deficiency,4534,"Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).","Is the triple ""Ergocalciferol causes vitamin D deficiency"" supported by the sentence: ""Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).""?",False, -11557464,Ergocalciferol causes inflammatory bowel disease,4535,Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.,"Is the triple ""Ergocalciferol causes inflammatory bowel disease"" supported by the sentence: ""Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.""?",False, -11275618,Ergocalciferol causes type 1 diabetes mellitus,4536,These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol causes type 1 diabetes mellitus"" supported by the sentence: ""These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.""?",False, -10362733,Ergocalciferol causes multiple sclerosis,4537,Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.,"Is the triple ""Ergocalciferol causes multiple sclerosis"" supported by the sentence: ""Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.""?",False, -8719466,Ergocalciferol causes diabetes mellitus,4538,"In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).","Is the triple ""Ergocalciferol causes diabetes mellitus"" supported by the sentence: ""In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).""?",False, -8407906,Ergocalciferol causes Marchiafava-Bignami disease,4539,Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.,"Is the triple ""Ergocalciferol causes Marchiafava-Bignami disease"" supported by the sentence: ""Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.""?",False, -7553325,Ergocalciferol causes prostate cancer,4540,"OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).","Is the triple ""Ergocalciferol causes prostate cancer"" supported by the sentence: ""OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).""?",False, -7357695,Ergocalciferol causes bone fracture,4541,Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.,"Is the triple ""Ergocalciferol causes bone fracture"" supported by the sentence: ""Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.""?",False, -25936029,Ergocalciferol affects nutritional disorder,4542,"Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.","Is the triple ""Ergocalciferol affects nutritional disorder"" supported by the sentence: ""Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.""?",False, -25430100,Ergocalciferol affects primary hyperparathyroidism,4543,Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.""?",False, -24682916,Ergocalciferol affects bone fracture,4544,"Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.""?",False, -24133915,Ergocalciferol affects HIV infectious disease,4545,Potential immune modulatory effect of vitamin D in HIV infection: A review.,"Is the triple ""Ergocalciferol affects HIV infectious disease"" supported by the sentence: ""Potential immune modulatory effect of vitamin D in HIV infection: A review.""?",False, -23716846,Ergocalciferol affects Premature birth,4546,Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.""?",False, -22436428,Ergocalciferol affects obesity disorder,4547,Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).,"Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).""?",False, -22382447,Ergocalciferol affects Pregnancy,4548,Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.""?",False, -21132793,Ergocalciferol affects breast neoplasm,4549,"As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.","Is the triple ""Ergocalciferol affects breast neoplasm"" supported by the sentence: ""As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.""?",False, -20959246,Ergocalciferol affects diabetes mellitus,4550,These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.,"Is the triple ""Ergocalciferol affects diabetes mellitus"" supported by the sentence: ""These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.""?",False, -20298561,Ergocalciferol affects inflammatory bowel disease,4551,"We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.","Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.""?",False, -20058982,Ergocalciferol affects gestational diabetes,4552,TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.""?",False, -19907316,Ergocalciferol affects gestational diabetes,4553,This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.""?",False, -19815602,Ergocalciferol affects ulcerative colitis,4554,Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.,"Is the triple ""Ergocalciferol affects ulcerative colitis"" supported by the sentence: ""Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.""?",False, -19320344,Ergocalciferol affects Premature birth,4555,We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.""?",False, -19221129,Ergocalciferol affects non-alcoholic fatty liver disease,4556,"Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.","Is the triple ""Ergocalciferol affects non-alcoholic fatty liver disease"" supported by the sentence: ""Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.""?",False, -18424308,Ergocalciferol affects vitamin D deficiency,4557,Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.,"Is the triple ""Ergocalciferol affects vitamin D deficiency"" supported by the sentence: ""Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.""?",False, -18115621,Ergocalciferol affects asthma,4558,"BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.""?",False, -17654393,Ergocalciferol affects optic neuritis,4559,"CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.","Is the triple ""Ergocalciferol affects optic neuritis"" supported by the sentence: ""CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.""?",False, -17646826,Ergocalciferol affects migraine disorder,4560,"However, the data examining the relation of vitamin D with migraine are limited.","Is the triple ""Ergocalciferol affects migraine disorder"" supported by the sentence: ""However, the data examining the relation of vitamin D with migraine are limited.""?",False, -17581908,Ergocalciferol affects Pain,4561,Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.,"Is the triple ""Ergocalciferol affects Pain"" supported by the sentence: ""Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.""?",False, -17056932,Ergocalciferol affects sarcopenia,4562,"Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.""?",False, -16630786,Ergocalciferol affects sarcopenia,4563,"Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.""?",False, -16542255,Ergocalciferol affects melanoma,4564,"Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.","Is the triple ""Ergocalciferol affects melanoma"" supported by the sentence: ""Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.""?",False, -16343274,Ergocalciferol affects restless legs syndrome,4565,"Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.","Is the triple ""Ergocalciferol affects restless legs syndrome"" supported by the sentence: ""Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.""?",False, -16273798,Ergocalciferol affects Insulin resistance,4566,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, -16273796,Ergocalciferol affects type 2 diabetes mellitus,4567,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, -15812657,Ergocalciferol affects prostate cancer,4568,Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.""?",False, -15750325,Ergocalciferol affects polycystic ovary syndrome,4569,"Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.","Is the triple ""Ergocalciferol affects polycystic ovary syndrome"" supported by the sentence: ""Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.""?",False, -15694248,Ergocalciferol affects mood disorder,4570,"BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.","Is the triple ""Ergocalciferol affects mood disorder"" supported by the sentence: ""BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.""?",False, -15543952,Ergocalciferol affects osteoporosis,4571,"Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.","Is the triple ""Ergocalciferol affects osteoporosis"" supported by the sentence: ""Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.""?",False, -15528071,Ergocalciferol affects Alzheimer disease,4572,These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.,"Is the triple ""Ergocalciferol affects Alzheimer disease"" supported by the sentence: ""These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.""?",False, -15258155,Ergocalciferol affects obesity disorder,4573,"Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.","Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.""?",False, -14609756,Ergocalciferol affects tuberculosis,4574,Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.,"Is the triple ""Ergocalciferol affects tuberculosis"" supported by the sentence: ""Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.""?",False, -14384550,Ergocalciferol affects psoriasis,4575,"CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.","Is the triple ""Ergocalciferol affects psoriasis"" supported by the sentence: ""CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.""?",False, -14233188,Ergocalciferol affects Insulin resistance,4576,The possible correlations of the calciotropic hormones with insulin resistance were also examined.,"Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""The possible correlations of the calciotropic hormones with insulin resistance were also examined.""?",False, -13916047,Ergocalciferol affects hip fracture,4577,"RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).""?",False, -13794313,Ergocalciferol affects multiple sclerosis,4578,"Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.""?",False, -13764162,Ergocalciferol affects type 2 diabetes mellitus,4579,The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.,"Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.""?",False, -13437693,Ergocalciferol affects Crohn disease,4580,These findings suggest that vitD may play a therapeutic role in CD.,"Is the triple ""Ergocalciferol affects Crohn disease"" supported by the sentence: ""These findings suggest that vitD may play a therapeutic role in CD.""?",False, -13211992,Ergocalciferol affects type 1 diabetes mellitus,4581,BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.""?",False, -13015298,Ergocalciferol affects asthma,4582,"Although vitamin D has important immunologic effects, its relation with asthma is unknown.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""Although vitamin D has important immunologic effects, its relation with asthma is unknown.""?",False, -12698804,Ergocalciferol affects chronic renal failure syndrome,4583,[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].,"Is the triple ""Ergocalciferol affects chronic renal failure syndrome"" supported by the sentence: ""[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].""?",False, -12502345,Ergocalciferol affects inflammatory bowel disease,4584,This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.,"Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.""?",False, -12032067,Ergocalciferol affects multiple sclerosis,4585,"If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.""?",False, -11831475,Ergocalciferol affects bone fracture,4586,"BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.""?",False, -10991167,Ergocalciferol affects type 1 diabetes mellitus,4587,CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.""?",False, -10917919,Ergocalciferol affects primary hyperparathyroidism,4588,Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.""?",False, -10608353,Ergocalciferol affects Pregnancy,4589,Effect of overdose of vitamin D2 on pregnancy in the rat.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Effect of overdose of vitamin D2 on pregnancy in the rat.""?",False, -8987937,Ergocalciferol affects hip fracture,4590,"To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.""?",False, -8925552,Ergocalciferol affects prostate cancer,4591,Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.""?",False, -8894668,Ergocalciferol affects Marchiafava-Bignami disease,4592,"However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.","Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.""?",False, -8321224,Ergocalciferol affects neoplasm,4593,Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.,"Is the triple ""Ergocalciferol affects neoplasm"" supported by the sentence: ""Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.""?",False, -7878820,Ergocalciferol affects Marchiafava-Bignami disease,4594,High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.,"Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.""?",False, -21952380,Ergocalciferol produces obesity disorder,4595,"Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.","Is the triple ""Ergocalciferol produces obesity disorder"" supported by the sentence: ""Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.""?",False, -21636964,Ergocalciferol produces asthma,4596,"Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.","Is the triple ""Ergocalciferol produces asthma"" supported by the sentence: ""Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.""?",False, -20636497,Ergocalciferol produces Pregnancy,4597,"Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.","Is the triple ""Ergocalciferol produces Pregnancy"" supported by the sentence: ""Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.""?",False, -20444810,Ergocalciferol produces Alzheimer disease,4598,"Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.","Is the triple ""Ergocalciferol produces Alzheimer disease"" supported by the sentence: ""Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.""?",False, -15318015,Ergocalciferol produces melanoma,4599,"Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.","Is the triple ""Ergocalciferol produces melanoma"" supported by the sentence: ""Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.""?",False, -14384547,Ergocalciferol produces psoriasis,4600,"Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.","Is the triple ""Ergocalciferol produces psoriasis"" supported by the sentence: ""Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.""?",False, +23573980,Methylprednisolone related to pneumonia,501,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,"Is the triple ""Methylprednisolone related to pneumonia"" supported by the sentence: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?",False, +23514846,Methylprednisolone related to carpal tunnel syndrome,502,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,"Is the triple ""Methylprednisolone related to carpal tunnel syndrome"" supported by the sentence: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?",False, +23364897,Methylprednisolone related to West syndrome,503,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,"Is the triple ""Methylprednisolone related to West syndrome"" supported by the sentence: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?",False, +22495910,Methylprednisolone related to myocarditis,504,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,"Is the triple ""Methylprednisolone related to myocarditis"" supported by the sentence: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?",False, +22175056,Methylprednisolone related to myopathy,505,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.","Is the triple ""Methylprednisolone related to myopathy"" supported by the sentence: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?",False, +20879022,Methylprednisolone related to Pain,506,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.","Is the triple ""Methylprednisolone related to Pain"" supported by the sentence: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?",False, +20342058,Methylprednisolone related to chronic progressive multiple sclerosis,507,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,"Is the triple ""Methylprednisolone related to chronic progressive multiple sclerosis"" supported by the sentence: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?",False, +20290784,Methylprednisolone related to membranous glomerulonephritis,508,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,"Is the triple ""Methylprednisolone related to membranous glomerulonephritis"" supported by the sentence: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?",False, +20286711,Methylprednisolone related to neuromyelitis optica,509,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".","Is the triple ""Methylprednisolone related to neuromyelitis optica"" supported by the sentence: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?",False, +19340184,Methylprednisolone related to chronic obstructive pulmonary disease,510,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,"Is the triple ""Methylprednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?",False, +18938435,Methylprednisolone related to graft versus host disease,511,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,"Is the triple ""Methylprednisolone related to graft versus host disease"" supported by the sentence: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?",False, +17333962,Methylprednisolone related to Inflammation,512,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,"Is the triple ""Methylprednisolone related to Inflammation"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?",False, +17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,513,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,"Is the triple ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?",False, +15936572,Methylprednisolone related to endocrine exophthalmos,514,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,"Is the triple ""Methylprednisolone related to endocrine exophthalmos"" supported by the sentence: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?",False, +15072844,Methylprednisolone related to Edema,515,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.","Is the triple ""Methylprednisolone related to Edema"" supported by the sentence: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?",False, +14876749,Methylprednisolone related to osteoarthritis,516,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,"Is the triple ""Methylprednisolone related to osteoarthritis"" supported by the sentence: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?",False, +14399082,Methylprednisolone related to aplastic anemia,517,Long-term results of high-dose methylprednisolone in aplastic anemia.,"Is the triple ""Methylprednisolone related to aplastic anemia"" supported by the sentence: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?",False, +14398237,Methylprednisolone related to IgA glomerulonephritis,518,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.","Is the triple ""Methylprednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?",False, +14278238,"Methylprednisolone related to dermatitis, atopic",519,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.","Is the triple ""Methylprednisolone related to dermatitis, atopic"" supported by the sentence: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?",False, +14166179,Methylprednisolone related to cardiac arrest,520,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.","Is the triple ""Methylprednisolone related to cardiac arrest"" supported by the sentence: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?",False, +12755316,Methylprednisolone related to plasma cell myeloma,521,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,"Is the triple ""Methylprednisolone related to plasma cell myeloma"" supported by the sentence: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?",False, +12183687,Methylprednisolone related to acute lymphoblastic leukemia,522,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,"Is the triple ""Methylprednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?",False, +11720471,Methylprednisolone related to systemic lupus erythematosus,523,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,"Is the triple ""Methylprednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?",False, +10812685,Methylprednisolone related to immunoglobulin a vasculitis,524,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,"Is the triple ""Methylprednisolone related to immunoglobulin a vasculitis"" supported by the sentence: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?",False, +10763477,Methylprednisolone related to ulcerative colitis,525,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,"Is the triple ""Methylprednisolone related to ulcerative colitis"" supported by the sentence: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?",False, +10558884,Methylprednisolone related to lupus nephritis,526,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,"Is the triple ""Methylprednisolone related to lupus nephritis"" supported by the sentence: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?",False, +10130342,Methylprednisolone related to adult acute respiratory distress syndrome,527,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.","Is the triple ""Methylprednisolone related to adult acute respiratory distress syndrome"" supported by the sentence: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?",False, +9229208,Methylprednisolone related to vestibular neuronitis,528,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.","Is the triple ""Methylprednisolone related to vestibular neuronitis"" supported by the sentence: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?",False, +9003326,Methylprednisolone related to systemic sclerosis,529,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,"Is the triple ""Methylprednisolone related to systemic sclerosis"" supported by the sentence: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?",False, +8447481,Methylprednisolone related to rheumatoid arthritis,530,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,"Is the triple ""Methylprednisolone related to rheumatoid arthritis"" supported by the sentence: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?",False, +8282330,Methylprednisolone related to spinal cord injury,531,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.","Is the triple ""Methylprednisolone related to spinal cord injury"" supported by the sentence: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?",False, +7944646,Methylprednisolone related to myasthenia gravis,532,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,"Is the triple ""Methylprednisolone related to myasthenia gravis"" supported by the sentence: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?",False, +7668599,Methylprednisolone related to multiple sclerosis,533,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,"Is the triple ""Methylprednisolone related to multiple sclerosis"" supported by the sentence: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?",False, +7443745,Methylprednisolone related to asthma,534,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.","Is the triple ""Methylprednisolone related to asthma"" supported by the sentence: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?",False, +24973247,Methylprednisolone causes lupus nephritis,535,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.","Is the triple ""Methylprednisolone causes lupus nephritis"" supported by the sentence: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?",False, +24161886,Methylprednisolone causes Edema,536,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,"Is the triple ""Methylprednisolone causes Edema"" supported by the sentence: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?",False, +18534953,Methylprednisolone causes Inflammation,537,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.","Is the triple ""Methylprednisolone causes Inflammation"" supported by the sentence: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?",False, +18260665,Methylprednisolone causes neoplasm,538,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,"Is the triple ""Methylprednisolone causes neoplasm"" supported by the sentence: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?",False, +17307095,Methylprednisolone causes pneumonia,539,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.","Is the triple ""Methylprednisolone causes pneumonia"" supported by the sentence: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?",False, +15906641,Methylprednisolone causes Pain,540,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,"Is the triple ""Methylprednisolone causes Pain"" supported by the sentence: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?",False, +13166073,Methylprednisolone causes thrombocytopenia,541,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.","Is the triple ""Methylprednisolone causes thrombocytopenia"" supported by the sentence: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?",False, +12672767,Methylprednisolone causes drug-induced liver injury,542,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.","Is the triple ""Methylprednisolone causes drug-induced liver injury"" supported by the sentence: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?",False, +8525599,Methylprednisolone causes myopathy,543,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.","Is the triple ""Methylprednisolone causes myopathy"" supported by the sentence: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?",False, +27357949,Methylprednisolone affects neoplasm,544,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.","Is the triple ""Methylprednisolone affects neoplasm"" supported by the sentence: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?",False, +24420470,Methylprednisolone affects Inflammation,545,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.","Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?",False, +23472756,Methylprednisolone affects Inflammation,546,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,"Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?",False, +20530617,Methylprednisolone affects systemic sclerosis,547,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.","Is the triple ""Methylprednisolone affects systemic sclerosis"" supported by the sentence: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?",False, +20254789,Methylprednisolone affects adult acute respiratory distress syndrome,548,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.","Is the triple ""Methylprednisolone affects adult acute respiratory distress syndrome"" supported by the sentence: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?",False, +17649050,Methylprednisolone affects optic nerve disorder,549,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,"Is the triple ""Methylprednisolone affects optic nerve disorder"" supported by the sentence: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?",False, +16634377,Methylprednisolone affects myasthenia gravis,550,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,"Is the triple ""Methylprednisolone affects myasthenia gravis"" supported by the sentence: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?",False, +16277488,Methylprednisolone affects neuromyelitis optica,551,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,"Is the triple ""Methylprednisolone affects neuromyelitis optica"" supported by the sentence: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?",False, +15906642,Methylprednisolone affects Pain,552,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?",False, +15610554,Methylprednisolone affects rheumatoid arthritis,553,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,"Is the triple ""Methylprednisolone affects rheumatoid arthritis"" supported by the sentence: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?",False, +15186368,Methylprednisolone affects graft versus host disease,554,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,"Is the triple ""Methylprednisolone affects graft versus host disease"" supported by the sentence: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?",False, +14891106,Methylprednisolone affects kidney disorder,555,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.","Is the triple ""Methylprednisolone affects kidney disorder"" supported by the sentence: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?",False, +11819955,Methylprednisolone affects spinal cord injury,556,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.","Is the triple ""Methylprednisolone affects spinal cord injury"" supported by the sentence: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?",False, +10845505,Methylprednisolone affects Pain,557,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?",False, +10048898,Methylprednisolone affects ulcerative colitis,558,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,"Is the triple ""Methylprednisolone affects ulcerative colitis"" supported by the sentence: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?",False, +9646753,Methylprednisolone affects multiple sclerosis,559,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,"Is the triple ""Methylprednisolone affects multiple sclerosis"" supported by the sentence: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?",False, +9346353,Methylprednisolone affects chronic obstructive pulmonary disease,560,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).","Is the triple ""Methylprednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?",False, +9107378,Methylprednisolone affects Edema,561,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.","Is the triple ""Methylprednisolone affects Edema"" supported by the sentence: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?",False, +8596544,Methylprednisolone affects asthma,562,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,"Is the triple ""Methylprednisolone affects asthma"" supported by the sentence: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?",False, +8330909,Methylprednisolone affects systemic lupus erythematosus,563,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,"Is the triple ""Methylprednisolone affects systemic lupus erythematosus"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?",False, +19744632,Methylprednisolone disrupts Edema,564,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.","Is the triple ""Methylprednisolone disrupts Edema"" supported by the sentence: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?",False, +18407557,Methylprednisolone disrupts thrombocytopenia,565,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,"Is the triple ""Methylprednisolone disrupts thrombocytopenia"" supported by the sentence: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?",False, +11106658,Methylprednisolone disrupts Pain,566,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.","Is the triple ""Methylprednisolone disrupts Pain"" supported by the sentence: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?",False, +8640603,Methylprednisolone disrupts Inflammation,567,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,"Is the triple ""Methylprednisolone disrupts Inflammation"" supported by the sentence: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?",False, +23934495,Methylprednisolone prevents Cognitive impairment,568,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.","Is the triple ""Methylprednisolone prevents Cognitive impairment"" supported by the sentence: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?",False, +20014108,Methylprednisolone prevents rheumatoid arthritis,569,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).","Is the triple ""Methylprednisolone prevents rheumatoid arthritis"" supported by the sentence: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?",False, +18266414,Methylprednisolone prevents Abdominal pain,570,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,"Is the triple ""Methylprednisolone prevents Abdominal pain"" supported by the sentence: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?",False, +14967074,Methylprednisolone prevents asthma,571,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,"Is the triple ""Methylprednisolone prevents asthma"" supported by the sentence: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?",False, +9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,572,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,"Is the triple ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?",False, +8345063,Methylprednisolone prevents Pain,573,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.","Is the triple ""Methylprednisolone prevents Pain"" supported by the sentence: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?",False, +8291272,Methylprednisolone prevents graft versus host disease,574,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,"Is the triple ""Methylprednisolone prevents graft versus host disease"" supported by the sentence: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?",False, +7980138,Methylprednisolone prevents spinal cord injury,575,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.","Is the triple ""Methylprednisolone prevents spinal cord injury"" supported by the sentence: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?",False, +7414405,Methylprednisolone prevents Edema,576,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.","Is the triple ""Methylprednisolone prevents Edema"" supported by the sentence: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?",False, +18106042,Methylprednisolone predisposes pneumonia,577,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,"Is the triple ""Methylprednisolone predisposes pneumonia"" supported by the sentence: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?",False, +9645180,Methylprednisolone predisposes Inflammation,578,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.","Is the triple ""Methylprednisolone predisposes Inflammation"" supported by the sentence: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?",False, +12905337,Cefotaxime related to Sepsis,579,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.","Is the triple ""Cefotaxime related to Sepsis"" supported by the sentence: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?",False, +24475300,Cefotaxime affects bacterial infectious disease,580,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.","Is the triple ""Cefotaxime affects bacterial infectious disease"" supported by the sentence: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?",False, +23922029,Cefotaxime affects Sepsis,581,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).","Is the triple ""Cefotaxime affects Sepsis"" supported by the sentence: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?",False, +18672205,Cefotaxime affects peritonitis,582,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.","Is the triple ""Cefotaxime affects peritonitis"" supported by the sentence: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?",False, +15853591,Cefotaxime prevents Sepsis,583,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.","Is the triple ""Cefotaxime prevents Sepsis"" supported by the sentence: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?",False, +19081412,Ceftriaxone prevents bacterial infectious disease,584,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.","Is the triple ""Ceftriaxone prevents bacterial infectious disease"" supported by the sentence: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?",False, +25827448,Gefarnate related to gastric ulcer,585,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,"Is the triple ""Gefarnate related to gastric ulcer"" supported by the sentence: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?",False, +24296137,Gefarnate related to duodenal ulcer,586,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,"Is the triple ""Gefarnate related to duodenal ulcer"" supported by the sentence: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?",False, +25993651,Gefarnate disrupts gastric ulcer,587,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,"Is the triple ""Gefarnate disrupts gastric ulcer"" supported by the sentence: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?",False, +17758516,Neobiotic related to Inflammation,588,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,"Is the triple ""Neobiotic related to Inflammation"" supported by the sentence: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?",False, +10690423,Neobiotic related to burn,589,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,"Is the triple ""Neobiotic related to burn"" supported by the sentence: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?",False, +20263460,Neobiotic affects neoplasm,590,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.","Is the triple ""Neobiotic affects neoplasm"" supported by the sentence: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?",False, +19744068,Neobiotic affects Inflammation,591,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,"Is the triple ""Neobiotic affects Inflammation"" supported by the sentence: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?",False, +24669492,Neobiotic disrupts bacterial infectious disease,592,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.","Is the triple ""Neobiotic disrupts bacterial infectious disease"" supported by the sentence: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?",False, +17119153,Neobiotic disrupts neoplasm,593,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,"Is the triple ""Neobiotic disrupts neoplasm"" supported by the sentence: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?",False, +26428369,Neobiotic prevents bacterial infectious disease,594,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Neobiotic prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, +25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,595,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,"Is the triple ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" supported by the sentence: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?",False, +22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,596,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.","Is the triple ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?",False, +21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,597,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,"Is the triple ""BLINATUMOMAB related to acute lymphoblastic leukemia"" supported by the sentence: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?",False, +27155094,Ciprofloxacin related to endophthalmitis,598,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,"Is the triple ""Ciprofloxacin related to endophthalmitis"" supported by the sentence: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?",False, +16836665,Ciprofloxacin related to Crohn disease,599,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,"Is the triple ""Ciprofloxacin related to Crohn disease"" supported by the sentence: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?",False, +19572117,Ciprofloxacin related to DNA Gyrase,600,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, +19572117,Ciprofloxacin related to DNA Gyrase,601,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, +12385742,Ciprofloxacin coexists with DNA Gyrase,602,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, +12385742,Ciprofloxacin coexists with DNA Gyrase,603,These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.,"Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""These data indicate that persistence of Pseudomonas aeruginosa to ciprofloxacin involves changes in DNA gyrase and is associated with pleiotropic changes in outer membrane proteins and lipopolysaccharide.""?",False, +17007621,Ciprofloxacin coexists with DNA Gyrase,604,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, +17007621,Ciprofloxacin coexists with DNA Gyrase,605,"We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.","Is the triple ""Ciprofloxacin coexists with DNA Gyrase"" supported by the sentence: ""We reveal here for the first time the architecture of the full-length Thermus thermophilus DNA gyrase alone and in a cleavage complex with a 155 bp DNA duplex in the presence of the antibiotic ciprofloxacin, using cryo-electron microscopy.""?",False, +9387116,Ciprofloxacin physically interacts with DNA Gyrase,606,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.","Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.""?",False, +8212496,Ciprofloxacin physically interacts with DNA Gyrase,607,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,"Is the triple ""Ciprofloxacin physically interacts with DNA Gyrase"" supported by the sentence: ""Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.""?",False, +25648466,Ciprofloxacin causes abscess,608,Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.,"Is the triple ""Ciprofloxacin causes abscess"" supported by the sentence: ""Distribution of [14C]-ciprofloxacin in experimentally induced intramuscular abscesses of rats.""?",False, +24716241,Ciprofloxacin causes peritonitis,609,The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.,"Is the triple ""Ciprofloxacin causes peritonitis"" supported by the sentence: ""The mean peak dialysate level (2.17 +/- 1.63 mg/l) exceeded the MIC of ciprofloxacin for 32 of 34 bacterial strains responsible for peritonitis.""?",False, +17154464,Ciprofloxacin causes prostatitis,610,"After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).","Is the triple ""Ciprofloxacin causes prostatitis"" supported by the sentence: ""After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8).""?",False, +14369807,Ciprofloxacin causes neutropenia,611,[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].,"Is the triple ""Ciprofloxacin causes neutropenia"" supported by the sentence: ""[Neutropenia caused by ciprofloxacin and Escherichia coli bacteremia. Bone marrow examination].""?",False, +13950319,Ciprofloxacin causes pneumonia,612,"According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.","Is the triple ""Ciprofloxacin causes pneumonia"" supported by the sentence: ""According to PK/PD analysis, the liposomal CPFX exhibited potent antibacterial effects against the causative organisms of pneumonia.""?",False, +10209213,Ciprofloxacin causes infectious disease,613,"Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.","Is the triple ""Ciprofloxacin causes infectious disease"" supported by the sentence: ""Conversely, some broad-spectrum antibiotics, including ureidopenicillins (e.g. piperacillin-tazobactam) and ciprofloxacin, are less likely to induce C. difficile infection.""?",False, +7113733,Ciprofloxacin causes osteomyelitis,614,A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.,"Is the triple ""Ciprofloxacin causes osteomyelitis"" supported by the sentence: ""A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described.""?",False, +21996198,Ciprofloxacin affects infectious disease,615,Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.,"Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""Novel enterocin E20c purified from Enterococcus hirae 20c synergised with ss-lactams and ciprofloxacin against Salmonella enterica.BACKGROUND: An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases.""?",False, +16563368,Ciprofloxacin affects Fever,616,"Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""Ciprofloxacin significantly reduced the occurrence of febrile episodes in patients with acute lymphoblastic leukemia in the induction phase of chemotherapy, but not in patients with lymphoma or in the consolidation phase of chemotherapy.""?",False, +16125923,Ciprofloxacin affects osteomyelitis,617,"Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.","Is the triple ""Ciprofloxacin affects osteomyelitis"" supported by the sentence: ""Effect of ciprofloxacin on experimental osteomyelitis in the rabbit tibia, induced with a mixed infection of Staphylococcus epidermidis and Bacteroides thetaiotaomicron.""?",False, +12942741,Ciprofloxacin affects Crohn disease,618,BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.,"Is the triple ""Ciprofloxacin affects Crohn disease"" supported by the sentence: ""BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole.""?",False, +11440816,Ciprofloxacin affects typhoid fever,619,A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.,"Is the triple ""Ciprofloxacin affects typhoid fever"" supported by the sentence: ""A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol.""?",False, +11267024,Ciprofloxacin affects eye infectious disorder,620,The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).,"Is the triple ""Ciprofloxacin affects eye infectious disorder"" supported by the sentence: ""The authors studied the bactericidal action and therapeutic effectiveness of ciprofloxacin in treating external ocular infections (bacterial conjunctivitis and bacterial blepharoconjunctivitis).""?",False, +10672042,Ciprofloxacin affects Abdominal Infection,621,The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.,"Is the triple ""Ciprofloxacin affects Abdominal Infection"" supported by the sentence: ""The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.""?",False, +9891814,Ciprofloxacin affects pneumonia,622,"This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.","Is the triple ""Ciprofloxacin affects pneumonia"" supported by the sentence: ""This study compared the in vitro activity of ertapenem, ceftriaxone, cefepime, ciprofloxacin and amoxicillin-clavulanate against 381 aerobic and facultative bacterial pathogens isolated from 320 patients with acute bacterial exacerbation of chronic bronchitis or community-acquired pneumonia.""?",False, +9122989,Ciprofloxacin affects infectious disease,623,"The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.","Is the triple ""Ciprofloxacin affects infectious disease"" supported by the sentence: ""The effect of a 21-day treatment with cefuroxime, vancomycin, tobramycin or ciprofloxacin on infection was studied in this model 42 days after surgery.""?",False, +8956826,Ciprofloxacin affects Pseudomonas infection,624,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects Pseudomonas infection"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, +8956825,Ciprofloxacin affects cystic fibrosis,625,"Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.","Is the triple ""Ciprofloxacin affects cystic fibrosis"" supported by the sentence: ""Ciprofloxacin is effective in complicated and severe lower respiratory tract infections, including those in patients with infective exacerbations of chronic bronchitis and cystic fibrosis, and pseudomonal infections.""?",False, +8669720,Ciprofloxacin affects Fever,626,"(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.","Is the triple ""Ciprofloxacin affects Fever"" supported by the sentence: ""(0.18 microg /mL) and AUC (0.99 microg .h/mL) of ciprofloxacin were significantly decreased, whereas its t1/2beta (2.75 h) and MRT (4.58 h) were prolonged in febrile than in normal goats.""?",False, +7886704,Ciprofloxacin affects bronchiectasis,627,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects bronchiectasis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, +7886701,Ciprofloxacin affects chronic bronchitis,628,AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.,"Is the triple ""Ciprofloxacin affects chronic bronchitis"" supported by the sentence: ""AIMS: To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment.""?",False, +7781719,Ciprofloxacin affects DNA Gyrase,629,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.","Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.""?",False, +7592205,Ciprofloxacin affects chronic obstructive pulmonary disease,630,"Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.","Is the triple ""Ciprofloxacin affects chronic obstructive pulmonary disease"" supported by the sentence: ""Azithromycin, sultamicillin, ciprofloxacin and cefaclor monohydrate were found to be effective in treating COPD exacerbations.""?",False, +18400322,Ciprofloxacin affects DNA Gyrase,631,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,"Is the triple ""Ciprofloxacin affects DNA Gyrase"" supported by the sentence: ""Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.""?",False, +26984478,Ciprofloxacin disrupts Fever,632,"In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.","Is the triple ""Ciprofloxacin disrupts Fever"" supported by the sentence: ""In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies.""?",False, +26466958,Ciprofloxacin disrupts pneumonia,633,"At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.","Is the triple ""Ciprofloxacin disrupts pneumonia"" supported by the sentence: ""At physiologically relevant concentrations of piperacillin and ciprofloxacin, ciprofloxacin had the highest rates of killing against K. pneumoniae.""?",False, +18480207,Ciprofloxacin disrupts infectious disease,634,"We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.","Is the triple ""Ciprofloxacin disrupts infectious disease"" supported by the sentence: ""We tested the effectiveness of keratin-based hydrogels (termed ""keratose"") loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.""?",False, +10323767,Ciprofloxacin disrupts bacterial infectious disease with sepsis,635,Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.,"Is the triple ""Ciprofloxacin disrupts bacterial infectious disease with sepsis"" supported by the sentence: ""Ciprofloxacin was administered orally in order to suppress bacteremia for 36 months.""?",False, +27242944,Ciprofloxacin prevents pyelonephritis,636,"In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.","Is the triple ""Ciprofloxacin prevents pyelonephritis"" supported by the sentence: ""In the present murine model of pyelonephritis, levofloxacin was superior to ciprofloxacin in preventing pyelonephritis and eradicating S. aureus.""?",False, +21807033,Ciprofloxacin prevents Infection,637,25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.,"Is the triple ""Ciprofloxacin prevents Infection"" supported by the sentence: ""25.2% of the urologists experienced ciprofloxacin resistance as a current problem in the prevention of biopsy related infections and 73.6% as a future problem.""?",False, +16138544,Ciprofloxacin prevents diarrheal disease,638,"Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.","Is the triple ""Ciprofloxacin prevents diarrheal disease"" supported by the sentence: ""Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.""?",False, +15438014,Ciprofloxacin prevents Sepsis,639,"CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.","Is the triple ""Ciprofloxacin prevents Sepsis"" supported by the sentence: ""CONCLUSIONS: The 24-hour clear-fluid diet and the use of disposable enemas combined with a regimen of ciprofloxacin decreased the rate of postbiopsy sepsis in patients who underwent transrectal ultrasound-guided prostate biopsy, but the results were not significantly different.""?",False, +14202377,Ciprofloxacin prevents plague,640,"Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.","Is the triple ""Ciprofloxacin prevents plague"" supported by the sentence: ""Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols.""?",False, +12292532,Ciprofloxacin prevents endophthalmitis,641,These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.,"Is the triple ""Ciprofloxacin prevents endophthalmitis"" supported by the sentence: ""These studies indicate that a combination of ciprofloxacin and dexamethasone has the potential for reducing the risk of PVR formation and aiding in the prevention of endophthalmitis.""?",False, +10767980,Ciprofloxacin prevents bacterial infectious disease with sepsis,642,"To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.","Is the triple ""Ciprofloxacin prevents bacterial infectious disease with sepsis"" supported by the sentence: ""To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.""?",False, +9947057,Ciprofloxacin prevents bacterial infectious disease,643,[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].,"Is the triple ""Ciprofloxacin prevents bacterial infectious disease"" supported by the sentence: ""[Prospective randomized trial of intravenous ciprofloxacin for prevention of bacterial infection in cirrhotic patients with esophageal variceal bleeding].""?",False, +8364719,Ciprofloxacin prevents pneumonia,644,The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.,"Is the triple ""Ciprofloxacin prevents pneumonia"" supported by the sentence: ""The susceptibility to ciprofloxacin decreased successively with decreasing susceptibility to cefuroxime for K. pneumoniae.""?",False, +8054296,Ciprofloxacin prevents infectious disease,645,"PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.","Is the triple ""Ciprofloxacin prevents infectious disease"" supported by the sentence: ""PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.""?",False, +18366035,Ciprofloxacin predisposes infectious disease,646,"Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.","Is the triple ""Ciprofloxacin predisposes infectious disease"" supported by the sentence: ""Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin.""?",False, +15459841,Ciprofloxacin predisposes bacterial infectious disease with sepsis,647,"CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.","Is the triple ""Ciprofloxacin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: The present study shows a significant correlation between ciprofloxacin resistance and fluoroquinolone use, and indicates that prior fluoroquinolone use seems to be the most important risk factor for ciprofloxacin-resistant E. coli bacteremia.""?",False, +8758764,Ciprofloxacin predisposes gonorrhea,648,These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.,"Is the triple ""Ciprofloxacin predisposes gonorrhea"" supported by the sentence: ""These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.""?",False, +15493028,Chloramphenicol disrupts acne,649,Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.,"Is the triple ""Chloramphenicol disrupts acne"" supported by the sentence: ""Lysis of P. acnes by the lytic factor was inhibited by adding chloramphenicol which was assumed to inhibit the release of lipoteichoic acid.""?",False, +21241586,Chloramphenicol prevents eye infectious disorder,650,"Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.","Is the triple ""Chloramphenicol prevents eye infectious disorder"" supported by the sentence: ""Chloramphenicol is experiencing its renaissance because it is widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and other useful antimicrobial peculiarities, such as the antibiofilm properties.""?",False, +16722213,Rebamipide causes osteoarthritis,651,Oral administration of rebamipide was initiated on the day of OA induction.,"Is the triple ""Rebamipide causes osteoarthritis"" supported by the sentence: ""Oral administration of rebamipide was initiated on the day of OA induction.""?",False, +27679650,Rebamipide affects peptic ulcer disease,652,Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.,"Is the triple ""Rebamipide affects peptic ulcer disease"" supported by the sentence: ""Rebamipide might act as a radical scavenger and have favorable effects on peptic ulcer diseases.""?",False, +10125846,Rebamipide affects gastric ulcer,653,Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.,"Is the triple ""Rebamipide affects gastric ulcer"" supported by the sentence: ""Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor.""?",False, +16923576,Rebamipide disrupts gastritis,654,"Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.","Is the triple ""Rebamipide disrupts gastritis"" supported by the sentence: ""Others reported that rebamipide, a gastroprotective drug, could not only increase the gastric mucus production, but also suppressed gastric mucosal inflammation and that it was dominantly distributed in mucosal tissues.""?",False, +20953135,Rebamipide prevents peptic ulcer disease,655,CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).,"Is the triple ""Rebamipide prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Rebamipide is safe and may prevent peptic ulcers >= 5 mm in diameter or those with pigmented spots in patients receiving dual antiplatelets for 1 year (NCT02166008).""?",False, +13727344,Rebamipide prevents gastritis,656,Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.,"Is the triple ""Rebamipide prevents gastritis"" supported by the sentence: ""Improvement of gastritis might be the mechanism by which rebamipide prevents gastric mucosal inflammation.""?",False, +10452606,Rebamipide prevents gastric ulcer,657,These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.,"Is the triple ""Rebamipide prevents gastric ulcer"" supported by the sentence: ""These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.""?",False, +23020953,DINUTUXIMAB related to neoplasm,658,"In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.","Is the triple ""DINUTUXIMAB related to neoplasm"" supported by the sentence: ""In summary, our data provide evidence that dinutuximab might be effective in tumors with high GD2 expression.""?",False, +12385638,DINUTUXIMAB related to neuroblastoma,659,The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.,"Is the triple ""DINUTUXIMAB related to neuroblastoma"" supported by the sentence: ""The mouse/human chimeric anti-GD2 mAb ch14.18 is already applied in melanoma and neuroblastoma trials as a passive immunotherapy.""?",False, +21974466,DINUTUXIMAB causes neuroblastoma,660,Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.,"Is the triple ""DINUTUXIMAB causes neuroblastoma"" supported by the sentence: ""Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing.""?",False, +23929422,BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma,661,INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).,"Is the triple ""BRENTUXIMAB VEDOTIN related to anaplastic large cell lymphoma"" supported by the sentence: ""INTRODUCTION: Brentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin's lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).""?",False, +23730531,BRENTUXIMAB VEDOTIN related to mycosis fungoides,662,"These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to mycosis fungoides"" supported by the sentence: ""These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL.""?",False, +23653011,BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma,663,Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.,"Is the triple ""BRENTUXIMAB VEDOTIN related to diffuse large B-cell lymphoma"" supported by the sentence: ""Our study thus provides a feasible explanation for the clinical impact of BV in CD30 - DLBCL and warrants confirming studies in animal models.""?",False, +23065539,BRENTUXIMAB VEDOTIN related to lymphoma,664,"Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.","Is the triple ""BRENTUXIMAB VEDOTIN related to lymphoma"" supported by the sentence: ""Clinical activity of targeted antibodies, such as daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL.""?",False, +21812241,BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma,665,Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.,"Is the triple ""BRENTUXIMAB VEDOTIN related to Hodgkins lymphoma"" supported by the sentence: ""Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.BACKGROUND CNS involvement in Hodgkin lymphoma is rare.""?",False, +21657994,BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma,666,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, +21657993,BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma,667,"In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.","Is the triple ""BRENTUXIMAB VEDOTIN related to primary cutaneous T-cell non-Hodgkin lymphoma"" supported by the sentence: ""In this review, we discuss key studies of BV in peripheral T cell lymphoma (PTCL) and cutaneous T cell lymphoma (CTCL) and highlight important questions for further investigation.""?",False, +22071488,BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma,668,Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.,"Is the triple ""BRENTUXIMAB VEDOTIN has part mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Targeting CD30+ PTCL with the antibody-drug conjugate brentuximab vedotin in the relapsed setting and in combination with chemotherapy in the frontline setting has improved patient survivals.""?",False, +21553377,BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma,669,"Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.","Is the triple ""BRENTUXIMAB VEDOTIN has part diffuse large B-cell lymphoma"" supported by the sentence: ""Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.""?",False, +23435913,BRENTUXIMAB VEDOTIN affects lymphoma,670,"Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.","Is the triple ""BRENTUXIMAB VEDOTIN affects lymphoma"" supported by the sentence: ""Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.""?",False, +20170701,Tetracycline causes periodontitis,671,"In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.","Is the triple ""Tetracycline causes periodontitis"" supported by the sentence: ""In conclusion, long term systemic administration of tetracycline in the rat may be of value in reducing the amount of tissue destruction in experimentally induced periodontitis.""?",False, +19472933,Tetracycline causes Helicobacter pylori infectious disease,672,"In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.","Is the triple ""Tetracycline causes Helicobacter pylori infectious disease"" supported by the sentence: ""In spite of the low reactivity of chloramines towards tetracycline, it is evident that, in the concentration range where they are produced in a H. pylori infection (millimolar range), the reactions lead to oxidation and/or chlorination of tetracycline.""?",False, +18080767,Tetracycline affects periodontitis,673,Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.,"Is the triple ""Tetracycline affects periodontitis"" supported by the sentence: ""Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.""?",False, +17969405,Tetracycline affects bacterial infectious disease,674,"We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.","Is the triple ""Tetracycline affects bacterial infectious disease"" supported by the sentence: ""We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.""?",False, +24565223,Tetracycline prevents bacterial infectious disease,675,"Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .","Is the triple ""Tetracycline prevents bacterial infectious disease"" supported by the sentence: ""Resistance to tetracycline, used to prevent bacterial infections in beehives, was only found in Bombella apis MRM1 T .""?",False, +10847016,Tetracycline prevents inclusion conjunctivitis,676,"Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.","Is the triple ""Tetracycline prevents inclusion conjunctivitis"" supported by the sentence: ""Prophylaxis with silver nitrate solution, 1.0% tetracycline, or 0.05% erythromycin ointment is effective for the prevention of gonococcal and chlamydial conjunctivitis in the newborn.""?",False, +12376615,(Alginate)n related to gastroesophageal reflux disease,677,Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.,"Is the triple ""(Alginate)n related to gastroesophageal reflux disease"" supported by the sentence: ""Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease.""?",False, +11754791,(Alginate)n related to cystic fibrosis,678,Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.,"Is the triple ""(Alginate)n related to cystic fibrosis"" supported by the sentence: ""Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.""?",False, +10599430,(Alginate)n related to obesity disorder,679,[Alginate--skimmed milk mixture as an aid in obesity].,"Is the triple ""(Alginate)n related to obesity disorder"" supported by the sentence: ""[Alginate--skimmed milk mixture as an aid in obesity].""?",False, +27435796,(Alginate)n affects cystic fibrosis,680,"Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.","Is the triple ""(Alginate)n affects cystic fibrosis"" supported by the sentence: ""Two CF strains, selected for further study based on the dependence of their alginate production on the concentration of salt in the medium, were used to examine the effects of mucoidy on pulmonary clearance.""?",False, +27132270,(Alginate)n affects gastroesophageal reflux disease,681,Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.""?",False, +23415127,(Alginate)n affects obesity disorder,682,"Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.","Is the triple ""(Alginate)n affects obesity disorder"" supported by the sentence: ""Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.""?",False, +19854419,(Alginate)n affects gastroesophageal reflux disease,683,Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.,"Is the triple ""(Alginate)n affects gastroesophageal reflux disease"" supported by the sentence: ""Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation.""?",False, +8246131,(Alginate)n disrupts gastroesophageal reflux disease,684,"Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.","Is the triple ""(Alginate)n disrupts gastroesophageal reflux disease"" supported by the sentence: ""Although some alginate-based formulations also contain antacid components which can provide significant acid neutralization capacity, the efficacy of these formulations to reduce heartburn symptoms does not appear to be totally dependent on the neutralization of bulk gastric contents.""?",False, +11492096,(Alginate)n prevents gastroesophageal reflux disease,685,Alginic acid decreases postprandial upright gastroesophageal reflux.,"Is the triple ""(Alginate)n prevents gastroesophageal reflux disease"" supported by the sentence: ""Alginic acid decreases postprandial upright gastroesophageal reflux.""?",False, +23508922,(Alginate)n predisposes obesity disorder,686,The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.,"Is the triple ""(Alginate)n predisposes obesity disorder"" supported by the sentence: ""The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.""?",False, +11597598,Zolimidine related to peptic ulcer disease,687,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Zolimidine related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, +20742970,Chlorhexidine causes infectious disease,688,"Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.","Is the triple ""Chlorhexidine causes infectious disease"" supported by the sentence: ""Chlorhexidine, for example, has been shown to cause markedly less SSIs compared with povidone-iodine prep in general surgery cases.""?",False, +16147932,Chlorhexidine causes gingivitis,689,CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.,"Is the triple ""Chlorhexidine causes gingivitis"" supported by the sentence: ""CONCLUSION: A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.""?",False, +15413413,Chlorhexidine causes stomatitis,690,Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.,"Is the triple ""Chlorhexidine causes stomatitis"" supported by the sentence: ""Current dermatitis or stomatitis caused by chlorhexidine-containing topical medicaments was seen in 5 patients.""?",False, +13735208,Chlorhexidine causes bacterial infectious disease with sepsis,691,Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.,"Is the triple ""Chlorhexidine causes bacterial infectious disease with sepsis"" supported by the sentence: ""Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit.""?",False, +23793676,Chlorhexidine affects Infection,692,This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.,"Is the triple ""Chlorhexidine affects Infection"" supported by the sentence: ""This meta-analysis aimed to examine the impact of CHX on infections after cardiac surgery compared with other cleansers or antiseptics.""?",False, +21319017,Chlorhexidine affects pneumonia,693,Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.,"Is the triple ""Chlorhexidine affects pneumonia"" supported by the sentence: ""Oral care with chlorhexidine may increase mortality risk and stress ulcer prophylaxis may facilitate pneumonia.""?",False, +20585434,Chlorhexidine affects stomatitis,694,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Chlorhexidine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, +13503760,Chlorhexidine affects periodontal disorder,695,"Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.","Is the triple ""Chlorhexidine affects periodontal disorder"" supported by the sentence: ""Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease.""?",False, +8506996,Chlorhexidine affects gingivitis,696,Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.,"Is the triple ""Chlorhexidine affects gingivitis"" supported by the sentence: ""Effect of chlorhexidine on dental plaque and gingivitis in mentally retarded children.""?",False, +25489531,"Chlorhexidine disrupts Pneumonia, Ventilator-Associated",697,"Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).","Is the triple ""Chlorhexidine disrupts Pneumonia, Ventilator-Associated"" supported by the sentence: ""Tooth brushing + 0.2%/0.12% chlorhexidine was associated with reduced incidence of VAP compared to chlorhexidine (OR = 0.63, 95% confidence interval [CI]: 0.43-0.91, P = .01) or tooth brushing + placebo (OR = 0.47, 95% CI: 0.25-0.86, P = .02) in patients with mechanical ventilation in ICU, but was similar to cotton wipe with 0.2% or 0.12% chlorhexidine (OR = 1.33, 95% CI: 0.77-2.29, P = .31).""?",False, +22304373,Chlorhexidine disrupts dental caries,698,This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.,"Is the triple ""Chlorhexidine disrupts dental caries"" supported by the sentence: ""This study sheds significant new light on the potential to develop TC in combination with chlorhexidine or fluoride as novel treatments to arrest dental caries.""?",False, +21939464,Chlorhexidine disrupts Infection,699,"In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).","Is the triple ""Chlorhexidine disrupts Infection"" supported by the sentence: ""In high-resource pediatric and adult intensive care units, use of aqueous chlorhexidine (CHG) solution has been associated with reduced risk of bloodstream infections (BSI).""?",False, +19793680,Chlorhexidine disrupts bacterial infectious disease,700,This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.,"Is the triple ""Chlorhexidine disrupts bacterial infectious disease"" supported by the sentence: ""This selective reduction in bacterial infectivity by chlorhexidine should be taken into account when conventional in vitro tests are used to assess the clinical effectiveness of chlorhexidine-containing antiseptics.""?",False, +18040358,Chlorhexidine disrupts infectious disease,701,Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.,"Is the triple ""Chlorhexidine disrupts infectious disease"" supported by the sentence: ""Using isopropyl alcohol to thoroughly remove all gel before application of chlorhexidine was associated with reduced rates of postsurgical infection at our institution.""?",False, +11272633,Chlorhexidine disrupts gingivitis,702,The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.,"Is the triple ""Chlorhexidine disrupts gingivitis"" supported by the sentence: ""The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation.""?",False, +26042520,Chlorhexidine prevents staphylococcal infection,703,"It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.","Is the triple ""Chlorhexidine prevents staphylococcal infection"" supported by the sentence: ""It is concluded that the superior activity of chlorhexidine in this model is a good indication that it should be a highly effective agent in the prevention of staphylococcal wound infection, and that this is probably due to a combination of bactericidal and persistent action together with low toxicity.""?",False, +22617089,Chlorhexidine prevents periodontitis,704,"Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.","Is the triple ""Chlorhexidine prevents periodontitis"" supported by the sentence: ""Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain.""?",False, +22038778,Chlorhexidine prevents bacterial infectious disease,705,"CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.","Is the triple ""Chlorhexidine prevents bacterial infectious disease"" supported by the sentence: ""CONCLUSION: Our findings suggest that both CHX and NaOCl can reduce bacterial infections after irrigation, without any significant difference in antimicrobial efficacy between them.""?",False, +22000060,Chlorhexidine prevents Infection,706,"Thus, CHX can be used to prevent subsequent biofilm infections.","Is the triple ""Chlorhexidine prevents Infection"" supported by the sentence: ""Thus, CHX can be used to prevent subsequent biofilm infections.""?",False, +21737487,"Chlorhexidine prevents Pneumonia, Ventilator-Associated",707,Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.,"Is the triple ""Chlorhexidine prevents Pneumonia, Ventilator-Associated"" supported by the sentence: ""Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation.""?",False, +19905103,Chlorhexidine prevents periodontal disorder,708,"The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.","Is the triple ""Chlorhexidine prevents periodontal disorder"" supported by the sentence: ""The findings of this study have illustrated the limited antibacterial activity of presently available toothpastes on the salivary flora compared to chlorhexidine, and as such, would tend to question the relative benefit of toothpaste in preventing periodontal disease through an antimicrobial effect.""?",False, +16765643,Chlorhexidine prevents Neonatal sepsis,709,AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).,"Is the triple ""Chlorhexidine prevents Neonatal sepsis"" supported by the sentence: ""AIM: To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).""?",False, +14052320,Chlorhexidine prevents pneumonia,710,Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.,"Is the triple ""Chlorhexidine prevents pneumonia"" supported by the sentence: ""Oral hygiene with chlorhexidine in preventing pneumonia associated with mechanical ventilation.""?",False, +11830955,Chlorhexidine prevents bacterial infectious disease with sepsis,711,"Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.","Is the triple ""Chlorhexidine prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Because the application of chlorhexidine and povidone-iodine before acid etching did not cause any decrease in bond strength, it is advisable for use under the orthodontic resin composite to obtain an antibacterial effect or to prevent the risk of bacteremia.""?",False, +11145796,Chlorhexidine prevents infectious disease,712,CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.,"Is the triple ""Chlorhexidine prevents infectious disease"" supported by the sentence: ""CONCLUSIONS: Skin disinfection with propanol/chlorhexidine followed by PVP-iodine was superior in the prevention of microbial CVC colonisation compared to either of the regimens alone.""?",False, +10739867,Chlorhexidine prevents stomatitis,713,"The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.","Is the triple ""Chlorhexidine prevents stomatitis"" supported by the sentence: ""The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection.""?",False, +10141569,Chlorhexidine prevents dental caries,714,The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.,"Is the triple ""Chlorhexidine prevents dental caries"" supported by the sentence: ""The literature remains mixed on the success of chlorhexidine for the reduction of dental caries.""?",False, +7990742,Chlorhexidine prevents gingivitis,715,"Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.","Is the triple ""Chlorhexidine prevents gingivitis"" supported by the sentence: ""Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.""?",False, +23454202,"Chlorhexidine predisposes Pneumonia, Ventilator-Associated",716,"The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.","Is the triple ""Chlorhexidine predisposes Pneumonia, Ventilator-Associated"" supported by the sentence: ""The meta-analysis revealed that the risk of VAP was 24% lower in patients receiving chlorhexidine combined with toothbrushing than in those receiving chlorhexidine alone (RR: 0.76; 95% confidence interval: 0.55-1.06), with moderate certainty of evidence and without statistical significance.""?",False, +19942414,Chlorhexidine predisposes periodontal disorder,717,CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.,"Is the triple ""Chlorhexidine predisposes periodontal disorder"" supported by the sentence: ""CLINICAL RELEVANCE: A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease.""?",False, +18735040,Chlorhexidine predisposes dental caries,718,"Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.","Is the triple ""Chlorhexidine predisposes dental caries"" supported by the sentence: ""Current evidence also indicates that use of specific oral topical agents like chlorhexidine, fluoride, and triclosan can aid in reducing risk for gingival inflammation, dental caries, and candidiasis.""?",False, +16765642,Chlorhexidine predisposes Neonatal sepsis,719,Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.,"Is the triple ""Chlorhexidine predisposes Neonatal sepsis"" supported by the sentence: ""Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.""?",False, +24905090,Nicergoline causes depressive disorder,720,"RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.","Is the triple ""Nicergoline causes depressive disorder"" supported by the sentence: ""RESULTS: A more pronounced reflex depression of the above-described effectors was caused by Nicergoline, it was less pronounced when using Vinpocetine and Pentoxifylline.""?",False, +25103280,RAMUCIRUMAB related to hepatocellular carcinoma,721,"Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.","Is the triple ""RAMUCIRUMAB related to hepatocellular carcinoma"" supported by the sentence: ""Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP) levels.""?",False, +22612331,RAMUCIRUMAB related to neoplasm,722,"CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.","Is the triple ""RAMUCIRUMAB related to neoplasm"" supported by the sentence: ""CONCLUSIONS: First-line therapy with ramucirumab plus pembrolizumab has a manageable safety profile in patients with NSCLC, and the efficacy signal seems to be strongest in tumors with high PD-L1 expression.""?",False, +21600131,RAMUCIRUMAB related to non-small cell lung carcinoma,723,Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.,"Is the triple ""RAMUCIRUMAB related to non-small cell lung carcinoma"" supported by the sentence: ""Randomized phase 1b/3 study of erlotinib plus ramucirumab in first-line EGFR mut + stage IV NSCLC: phase 1b safety results.""?",False, +22008312,RAMUCIRUMAB affects neoplasm,724,"This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).","Is the triple ""RAMUCIRUMAB affects neoplasm"" supported by the sentence: ""This multicenter phase II N-DOCC-F-C-1701 trial is being planned in order to investigate the efficacy and safety of CPT-11+S-1 +Ramucirumab (IRIS+Rmab), which is anticipated to have a stronger anti-tumor effect than IRIS+Bmab in patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin (L-OHP) containing regimen, in consideration of the result of RAISE, FIRIS and some phase II trials of IRIS+Bevacicizumab (Bmab).""?",False, +23569571,TAFASITAMAB related to diffuse large B-cell lymphoma,725,The use of tafasitamab in diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB related to diffuse large B-cell lymphoma"" supported by the sentence: ""The use of tafasitamab in diffuse large B-cell lymphoma.""?",False, +24533103,TAFASITAMAB disrupts diffuse large B-cell lymphoma,726,MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.,"Is the triple ""TAFASITAMAB disrupts diffuse large B-cell lymphoma"" supported by the sentence: ""MANAGEMENT AND OUTCOME: Tafasitamab and reduced dose lenalidomide were initiated for relapsed diffuse large B-cell lymphoma.""?",False, +21884997,Thioctic acid related to cystinuria,727,alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.,"Is the triple ""Thioctic acid related to cystinuria"" supported by the sentence: ""alpha-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.""?",False, +20207321,Thioctic acid related to chronic progressive multiple sclerosis,728,Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.,"Is the triple ""Thioctic acid related to chronic progressive multiple sclerosis"" supported by the sentence: ""Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS.""?",False, +18115881,Thioctic acid related to hypertensive disorder,729,"INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.","Is the triple ""Thioctic acid related to hypertensive disorder"" supported by the sentence: ""INTRODUCTION: The ?-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism.""?",False, +15406106,Thioctic acid related to optic neuritis,730,This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.,"Is the triple ""Thioctic acid related to optic neuritis"" supported by the sentence: ""This study provides a rationale for investigating the therapeutic efficacy of LA in acute optic neuritis in humans.""?",False, +12204809,Thioctic acid related to type 2 diabetes mellitus,731,"As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.","Is the triple ""Thioctic acid related to type 2 diabetes mellitus"" supported by the sentence: ""As can be expected, administration of antioxidants such as lipoic acid in oxidized cells, in animal models of diabetes, and in type 2 diabetes shows improved insulin sensitivity.""?",False, +11741203,Thioctic acid related to multiple sclerosis,732,Lipoic acid in multiple sclerosis: a pilot study.,"Is the triple ""Thioctic acid related to multiple sclerosis"" supported by the sentence: ""Lipoic acid in multiple sclerosis: a pilot study.""?",False, +11010945,Thioctic acid related to AIDS,733,These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.,"Is the triple ""Thioctic acid related to AIDS"" supported by the sentence: ""These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.""?",False, +10648973,Thioctic acid related to skin disorder,734,[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].,"Is the triple ""Thioctic acid related to skin disorder"" supported by the sentence: ""[Studies on the metabolism of thioctic acid in skin diseases. II. Quantitative determination of thioctic acid in various skin diseases].""?",False, +7603472,Thioctic acid related to diabetic neuropathy,735,[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].,"Is the triple ""Thioctic acid related to diabetic neuropathy"" supported by the sentence: ""[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].""?",False, +16842192,Thioctic acid causes hypertensive disorder,736,"AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.","Is the triple ""Thioctic acid causes hypertensive disorder"" supported by the sentence: ""AIMS: To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition.""?",False, +21111426,Thioctic acid affects optic neuritis,737,"Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.","Is the triple ""Thioctic acid affects optic neuritis"" supported by the sentence: ""Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis.""?",False, +18505755,Thioctic acid affects diabetic neuropathy,738,"Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.","Is the triple ""Thioctic acid affects diabetic neuropathy"" supported by the sentence: ""Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.""?",False, +17198477,Thioctic acid affects type 2 diabetes mellitus,739,"A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.","Is the triple ""Thioctic acid affects type 2 diabetes mellitus"" supported by the sentence: ""A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.""?",False, +12393284,Thioctic acid affects Alzheimer disease,740,"The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.","Is the triple ""Thioctic acid affects Alzheimer disease"" supported by the sentence: ""The study demonstrated the effectiveness of alpha lipoic acid, melatonin and trans resveratrol in preventing spatial memory deficit induced by intracerebroventricular streptozotocin and it's potential in age related neurodegenerative disorders where oxidative stress is involved such as Alzheimer's disease.""?",False, +9028391,Thioctic acid affects hypertensive disorder,741,"Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.","Is the triple ""Thioctic acid affects hypertensive disorder"" supported by the sentence: ""Daily administration of 100 mg/kg alpha-lipoic acid for 2 weeks suppressed the increase in systolic blood pressure, whereas 10 mg/kg alpha-lipoic acid did not affect the progression of DOCA-salt-induced hypertension.""?",False, +21111429,Thioctic acid prevents optic neuritis,742,Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.,"Is the triple ""Thioctic acid prevents optic neuritis"" supported by the sentence: ""Objective: To determine whether lipoic acid is neuroprotective in acute optic neuritis.""?",False, +18775341,Thioctic acid prevents skin disorder,743,"Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.","Is the triple ""Thioctic acid prevents skin disorder"" supported by the sentence: ""Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.""?",False, +18076378,Thioctic acid prevents type 2 diabetes mellitus,744,"Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.","Is the triple ""Thioctic acid prevents type 2 diabetes mellitus"" supported by the sentence: ""Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population.""?",False, +15377554,Thioctic acid prevents stroke disorder,745,We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.,"Is the triple ""Thioctic acid prevents stroke disorder"" supported by the sentence: ""We tested the hypothesis that lipoic acid is protective against the cell death observed following stroke.""?",False, +13878249,Thioctic acid prevents Alzheimer disease,746,Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.,"Is the triple ""Thioctic acid prevents Alzheimer disease"" supported by the sentence: ""Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.""?",False, +8826102,Thioctic acid prevents hypertensive disorder,747,"The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.","Is the triple ""Thioctic acid prevents hypertensive disorder"" supported by the sentence: ""The aim of this work was to investigate whether dietary supplementation of an endogenous fatty acid, alpha-lipoic acid, another thiol compound known to increase cysteine and glutathione, prevents this hypertension and its associated biochemical and histopathological changes.""?",False, +8682086,Thioctic acid prevents diabetic neuropathy,748,alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.,"Is the triple ""Thioctic acid prevents diabetic neuropathy"" supported by the sentence: ""alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy.""?",False, +15385084,Thioctic acid predisposes Alzheimer disease,749,"Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.","Is the triple ""Thioctic acid predisposes Alzheimer disease"" supported by the sentence: ""Modulatory effects of vitamin E, acetyl-L-carnitine and alpha-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.""?",False, +26276598,Ampicillin related to Sepsis,750,Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.,"Is the triple ""Ampicillin related to Sepsis"" supported by the sentence: ""Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved.""?",False, +19644222,Ampicillin related to pneumonia,751,"This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.","Is the triple ""Ampicillin related to pneumonia"" supported by the sentence: ""This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina.""?",False, +27702232,Ampicillin causes Sepsis,752,Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.,"Is the triple ""Ampicillin causes Sepsis"" supported by the sentence: ""Gut-derived sepsis was induced by administering cyclophosphamide and ampicillin while feeding P. aeruginosa to specific-pathogen-free mice.""?",False, +15854005,Ampicillin causes pneumonia,753,"Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.","Is the triple ""Ampicillin causes pneumonia"" supported by the sentence: ""Lysis of superinfecting bacteria by ampicillin caused an extensive influx of neutrophils into the lungs resulting in a consolidative pneumonia, necrotic lung damage, and significant mortality.""?",False, +14938843,Ampicillin affects Sepsis,754,"No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.","Is the triple ""Ampicillin affects Sepsis"" supported by the sentence: ""No change in the incidence of ampicillin-resistant EOS was observed, but resistant cases were associated with peripartum ampicillin exposure.""?",False, +8930713,Ampicillin affects gonorrhea,755,A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.,"Is the triple ""Ampicillin affects gonorrhea"" supported by the sentence: ""A close correlation was found between the sensitivities of gonococcal strains to ampicillin and to penicillin.""?",False, +21012437,Ampicillin disrupts gonorrhea,756,"Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.","Is the triple ""Ampicillin disrupts gonorrhea"" supported by the sentence: ""Clavulanic acid combined with ampicillin inhibited beta-lactamase-producing N. gonorrhoeae, H. influenzae, Escherichia coli, Salmonella typhi, and Shigella sonnei.""?",False, +24823382,Ampicillin prevents Infection,757,"Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.","Is the triple ""Ampicillin prevents Infection"" supported by the sentence: ""Objective: Perioperative prophylaxis, commonly with a third-generation cephalosporin plus ampicillin or piperacillin-tazobactam, is usually employed to prevent infections in liver transplantation (LT) recipients.""?",False, +22838487,Ampicillin prevents chorioamnionitis,758,OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.,"Is the triple ""Ampicillin prevents chorioamnionitis"" supported by the sentence: ""OBJECTIVE: To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis.""?",False, +18801502,Ampicillin prevents Sepsis,759,"JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.","Is the triple ""Ampicillin prevents Sepsis"" supported by the sentence: ""JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim-sulfadoxine on days 0-4 for prevention of line sepsis.""?",False, +17465667,Ampicillin prevents pneumonia,760,"Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).","Is the triple ""Ampicillin prevents pneumonia"" supported by the sentence: ""Ampicillin compared to supportive care (continuation of breastfeeding, clearing of the nose and paracetamol for fever control) to prevent pneumonia showed a RR of 1.05 (95% CI 0.74 to 1.49, one trial, 889 selected children, moderate-quality evidence).""?",False, +13675414,Ampicillin predisposes Sepsis,761,Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.,"Is the triple ""Ampicillin predisposes Sepsis"" supported by the sentence: ""Intrapartum ampicillin exposure was determined to be an independent risk factor for ampicillin-resistant E. coli early-onset sepsis.""?",False, +26048573,Carbenicillin causes bacterial infectious disease,762,"Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.","Is the triple ""Carbenicillin causes bacterial infectious disease"" supported by the sentence: ""Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980.""?",False, +19319362,Benzoyl Peroxide related to acne,763,"Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.","Is the triple ""Benzoyl Peroxide related to acne"" supported by the sentence: ""Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.""?",False, +10427135,Benzoyl Peroxide affects acne,764,The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).,"Is the triple ""Benzoyl Peroxide affects acne"" supported by the sentence: ""The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed).""?",False, +7769964,Benzoyl Peroxide disrupts acne,765,We used benzoyl peroxide to bring about rapid suppression of P acnes.,"Is the triple ""Benzoyl Peroxide disrupts acne"" supported by the sentence: ""We used benzoyl peroxide to bring about rapid suppression of P acnes.""?",False, +12531968,Benzoyl Peroxide prevents acne,766,"Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.","Is the triple ""Benzoyl Peroxide prevents acne"" supported by the sentence: ""Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients.""?",False, +11597597,Proglumide related to peptic ulcer disease,767,"[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].","Is the triple ""Proglumide related to peptic ulcer disease"" supported by the sentence: ""[Double-blind study of proglumide, zolimidine and carbenoxolone in peptic ulcer and gastroduodenitis].""?",False, +18195146,Pirenzepine causes peptic ulcer disease,768,Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.,"Is the triple ""Pirenzepine causes peptic ulcer disease"" supported by the sentence: ""Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations.""?",False, +13022427,Pirenzepine affects gastroesophageal reflux disease,769,"However, the effect of pirenzepine on GERD remains to be defined.","Is the triple ""Pirenzepine affects gastroesophageal reflux disease"" supported by the sentence: ""However, the effect of pirenzepine on GERD remains to be defined.""?",False, +18547780,Pirenzepine prevents peptic ulcer disease,770,Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.,"Is the triple ""Pirenzepine prevents peptic ulcer disease"" supported by the sentence: ""Pirenzepine prevents cysteamine-induced formation of gastroduodenal ulcers and reduction of mesenteric circulation.""?",False, +9345084,Magnesium Oxide related to constipation disorder,771,"In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.","Is the triple ""Magnesium Oxide related to constipation disorder"" supported by the sentence: ""In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.""?",False, +19628284,Magnesium Oxide disrupts constipation disorder,772,"However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.","Is the triple ""Magnesium Oxide disrupts constipation disorder"" supported by the sentence: ""However, magnesium oxide at doses of ?2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d.""?",False, +25714783,Ticarcillin prevents Sepsis,773,A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.,"Is the triple ""Ticarcillin prevents Sepsis"" supported by the sentence: ""A comparison of cephazolin plus metronidazole versus ticarcillin in the prevention of post-operative sepsis following abdominal surgery.""?",False, +24735602,Urea related to hepatocellular carcinoma,774,"Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.","Is the triple ""Urea related to hepatocellular carcinoma"" supported by the sentence: ""Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC.""?",False, +18901918,Urea related to radiodermatitis,775,AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.,"Is the triple ""Urea related to radiodermatitis"" supported by the sentence: ""AIM: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis.""?",False, +16423422,Urea related to skin disorder,776,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to skin disorder"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, +16423421,Urea related to psoriasis,777,"Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.","Is the triple ""Urea related to psoriasis"" supported by the sentence: ""Topical vehicles containing urea are increasingly used in dermatology because of their favorable pharmacological properties, which are due to the following capacities of urea: (1) its beneficial influence on the structure and physiology of the skin, and (2) its therapeutic effect in combination with other topically active agents in various skin diseases, such as psoriasis, ichthyosis, and chronic eczema.""?",False, +10983160,"Urea related to dermatitis, atopic",778,[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].,"Is the triple ""Urea related to dermatitis, atopic"" supported by the sentence: ""[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].""?",False, +9883467,Urea related to diabetes mellitus,779,"Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.","Is the triple ""Urea related to diabetes mellitus"" supported by the sentence: ""Pharmacokinetic studies of the new antidiabetic agent gliquidone, AR-DF 26, 1-cyclohexyl-3-((p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2 (1H)-isoquinolyl)-ethyl]-phenyl)-sulfonyl)-urea (Glurenorm) in healthy volunteers and patients with several diseases related to diabetes are reported.""?",False, +9435238,Urea related to type 2 diabetes mellitus,780,"Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.","Is the triple ""Urea related to type 2 diabetes mellitus"" supported by the sentence: ""Two substituted ureas of beta-D-glucose, N-acetyl-N'-beta-D-glucopyranosyl urea (Acurea) and N-benzoyl-N'-beta-D-glucopyranosyl urea (Bzurea), have been identified as inhibitors of glycogen phosphorylase, a potential target for therapeutic intervention in type 2 diabetes.""?",False, +7778173,Urea related to ornithine carbamoyltransferase deficiency,781,We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).,"Is the triple ""Urea related to ornithine carbamoyltransferase deficiency"" supported by the sentence: ""We report effects of gene transfer and liver transplantation on urea synthesis in ornithine transcarbamylase deficiency (OTCD).""?",False, +17162115,Urea causes diabetes mellitus,782,"Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.","Is the triple ""Urea causes diabetes mellitus"" supported by the sentence: ""Diabetic kidney damage was diagnosed by renal hypertrophy, thickened glomerular basement membrane, widened filtration slits, mesangial expansion, as well as by elevated levels of blood urea and creatinine in diabetic rats 2 months after induction of diabetes.""?",False, +16469778,Urea causes type 2 diabetes mellitus,783,"To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.","Is the triple ""Urea causes type 2 diabetes mellitus"" supported by the sentence: ""To contribute to the understanding of experimental pharmacology and therapeutics of GKAs, we have tested the efficacy of one of these agents (Piragliatin) in isolated islets from humans with type 2 diabetes mellitus (T2DM), from mice with glucokinase (GK) mutations induced by ethyl-nitroso-urea (ENU) as models of Maturity Onset Diabetes of the Young linked to GK and Permanent Neonatal Diabetes Mellitus linked to GK (PNDM-GK) and finally of islets rendered glucose insensitive by treatment with the sulphonyl urea compound glyburide in organ culture.""?",False, +18510405,Urea affects hepatocellular carcinoma,784,[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].,"Is the triple ""Urea affects hepatocellular carcinoma"" supported by the sentence: ""[Therapeutic mechanisms and effects of urea in treating mouse transplantable hepatocellular carcinoma].""?",False, +10531949,Urea affects diabetes mellitus,785,[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].,"Is the triple ""Urea affects diabetes mellitus"" supported by the sentence: ""[Clinical experiences concerning the effects of N-sulfanilyl-N'-butyl urea in diabetes mellitus].""?",False, +8735554,Urea affects type 2 diabetes mellitus,786,Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.,"Is the triple ""Urea affects type 2 diabetes mellitus"" supported by the sentence: ""Amino acid catabolism and urea synthesis are increased in type 2 diabetes mellitus in poor metabolic control.""?",False, +25972859,Urea produces citrullinemia,787,Citrullinemia with defective urea production.,"Is the triple ""Urea produces citrullinemia"" supported by the sentence: ""Citrullinemia with defective urea production.""?",False, +18901919,Urea prevents radiodermatitis,788,This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.,"Is the triple ""Urea prevents radiodermatitis"" supported by the sentence: ""This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.""?",False, +15303897,Urea prevents Palmar-plantar erythrodysesthesia syndrome,789,This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.,"Is the triple ""Urea prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""This trial was conducted on the basis of preliminary data that a urea/lactic acid-based topical keratolytic agent (ULABTKA) may prevent HFS.""?",False, +19154964,Urea predisposes type 2 diabetes mellitus,790,"A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.","Is the triple ""Urea predisposes type 2 diabetes mellitus"" supported by the sentence: ""A combination of six metabolites including proline, glycerol, aminomalonic acid, LPI (16:1), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and urea showed the potential to predict type 2 diabetes in at-risk individuals with high baseline HbA1c levels (?6.5% [47.5 mmol/mol]) with an AUC of 0.935.""?",False, +21175471,Mannitol related to intracranial hypertension,791,"To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.","Is the triple ""Mannitol related to intracranial hypertension"" supported by the sentence: ""To evaluate this contention, we compared mannitol with normal saline administration in a canine model combining elevated intracranial pressure (ICP) and hemorrhagic shock.""?",False, +17706176,Mannitol related to acute kidney failure,792,"Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.","Is the triple ""Mannitol related to acute kidney failure"" supported by the sentence: ""Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis.""?",False, +17429747,Mannitol related to stroke disorder,793,The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.,"Is the triple ""Mannitol related to stroke disorder"" supported by the sentence: ""The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.""?",False, +15130853,Mannitol related to brain cancer,794,"In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.","Is the triple ""Mannitol related to brain cancer"" supported by the sentence: ""In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.""?",False, +13201402,Mannitol related to cystic fibrosis,795,Inhaled mannitol in cystic fibrosis.,"Is the triple ""Mannitol related to cystic fibrosis"" supported by the sentence: ""Inhaled mannitol in cystic fibrosis.""?",False, +12470912,Mannitol related to brain edema,796,"The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.","Is the triple ""Mannitol related to brain edema"" supported by the sentence: ""The effect of intravenous fluid replacement on the response to mannitol in experimental cerebral edema: an analysis of intracranial pressure, serum osmolality, serum electrolytes, and brain water content.""?",False, +11875924,Mannitol related to ciguatera fish poisoning,797,"The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.","Is the triple ""Mannitol related to ciguatera fish poisoning"" supported by the sentence: ""The basis for the neuroprotectant effect of D-mannitol in reducing the sensory neurological disturbances seen in ciguatera poisoning, is unclear.""?",False, +10780851,Mannitol related to brain injury,798,Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.,"Is the triple ""Mannitol related to brain injury"" supported by the sentence: ""Protective effects of alpha-tocopherol and mannitol in both circulatory shock and cerebral ischaemia injury in rat heatstroke.""?",False, +8946483,Mannitol related to bronchiectasis,799,"REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.","Is the triple ""Mannitol related to bronchiectasis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Dry powder mannitol has been shown to improve tracheobronchial clearance in bronchiectasis, as well as cystic fibrosis, asthmatics, and normal subjects.""?",False, +7891128,Mannitol related to injury,800,"The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.","Is the triple ""Mannitol related to injury"" supported by the sentence: ""The authors conclude that the therapeutic value of mannitol may, in some injuries, be directly related to its effects on blood flow and metabolism, as well as to its better known effects upon ICP.""?",False, +26278567,Mannitol causes brain cancer,801,Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.,"Is the triple ""Mannitol causes brain cancer"" supported by the sentence: ""Furosemide and mannitol - induced changes in intracranial pressure during the removal of intracranial tumours.""?",False, +25099324,Mannitol causes hearing loss disorder,802,A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.,"Is the triple ""Mannitol causes hearing loss disorder"" supported by the sentence: ""A combination of delayed NAC/STS with mannitol (t = 6) was better than NAC/STS (t = 6) alone at providing partial to full protection against cisplatin with mannitol-induced hearing loss.""?",False, +21259902,Mannitol causes brain injury,803,"In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.","Is the triple ""Mannitol causes brain injury"" supported by the sentence: ""In conclusion, infusion of hypertonic mannitol or urea into the carotid artery of the rat may result in structural brain damage within regions showing BBB injury.""?",False, +18351985,Mannitol causes hypotensive disorder,804,"All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.","Is the triple ""Mannitol causes hypotensive disorder"" supported by the sentence: ""All patients received 500 to 800 mg of phenytoin and 10 to 20 mg of dexamethasone shortly before and during surgery, and mannitol (0.8 g/kg) 15 minutes before the induction of hypotension or temporary clipping.""?",False, +15545947,Mannitol causes brain edema,805,"This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.","Is the triple ""Mannitol causes brain edema"" supported by the sentence: ""This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.""?",False, +12105301,Mannitol causes intracranial hypertension,806,"There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.","Is the triple ""Mannitol causes intracranial hypertension"" supported by the sentence: ""There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.""?",False, +11383337,Mannitol causes injury,807,DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.,"Is the triple ""Mannitol causes injury"" supported by the sentence: ""DISCUSSION: Non-heart beating donor kidneys are considered marginal and the effect of mannitol and paracetamol drug intoxication will induce reversible sub-lethal injury.""?",False, +9825580,Mannitol causes acute kidney failure,808,"In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.","Is the triple ""Mannitol causes acute kidney failure"" supported by the sentence: ""In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h.""?",False, +22439282,Mannitol affects acute kidney failure,809,Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.,"Is the triple ""Mannitol affects acute kidney failure"" supported by the sentence: ""Effect of mannitol on acute kidney injury induced by cisplatin.PURPOSE: Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin.""?",False, +18431992,Mannitol affects hypotensive disorder,810,It is unknown if mannitol is a contributing factor in the observed hypotension.,"Is the triple ""Mannitol affects hypotensive disorder"" supported by the sentence: ""It is unknown if mannitol is a contributing factor in the observed hypotension.""?",False, +10780860,Mannitol affects brain injury,811,"Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.","Is the triple ""Mannitol affects brain injury"" supported by the sentence: ""Herein, we investigated the effect on heat stroke-induced circulatory shock and cerebral ischaemic injury of two free radical scavengers, namely mannitol and alpha-tocopherol.""?",False, +10701562,Mannitol affects injury,812,THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.,"Is the triple ""Mannitol affects injury"" supported by the sentence: ""THE EFFECT OF PRETREATMENT WITH 10 PER CENT MANNITOL IN PERIPHERAL TRAUMA.""?",False, +10686125,"Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive",813,"EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.","Is the triple ""Mannitol affects chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""EFFECT OF 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL ON CHRONIC GRANULOCYTIC LEUKEMIA.""?",False, +9315186,Mannitol affects intracranial hypertension,814,"OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.","Is the triple ""Mannitol affects intracranial hypertension"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits.""?",False, +7084537,Mannitol affects brain edema,815,The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.,"Is the triple ""Mannitol affects brain edema"" supported by the sentence: ""The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.""?",False, +27493988,Mannitol disrupts injury,816,"We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.","Is the triple ""Mannitol disrupts injury"" supported by the sentence: ""We found that the PM10 particles did cause damage to the DNA that was mediated by hydroxyl radicals, as shown by inhibition of the injury with mannitol.""?",False, +26052295,Mannitol disrupts brain edema,817,Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.,"Is the triple ""Mannitol disrupts brain edema"" supported by the sentence: ""Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.""?",False, +18331127,Mannitol prevents Pain,818,"Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.","Is the triple ""Mannitol prevents Pain"" supported by the sentence: ""Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial.""?",False, +17838550,Mannitol prevents brain injury,819,"Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.","Is the triple ""Mannitol prevents brain injury"" supported by the sentence: ""Intravenous infusion of mannitol (1.5 g/kg, under thiopental anesthesia) which prevents seizures and post-seizure brain damage suppressed the changes in CGRP-like immunoreactivity.""?",False, +9550870,Mannitol prevents acute kidney failure,820,"However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.","Is the triple ""Mannitol prevents acute kidney failure"" supported by the sentence: ""However, forced diuresis by intravenous administration of mannitol and furosemide can prevent acute renal failure.""?",False, +8530867,Mannitol prevents brain edema,821,BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.,"Is the triple ""Mannitol prevents brain edema"" supported by the sentence: ""BACKGROUND: Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.""?",False, +7816754,Mannitol prevents intracranial hypertension,822,"For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.","Is the triple ""Mannitol prevents intracranial hypertension"" supported by the sentence: ""For the prevention of intracranial hypertension due to the edema in the myoflap, when we did EDAMS with dural pedicle insertion, we put into practice the new ideas about shaving the boneflaps to half of their original thickness, and prescribed 20% Mannitol after surgery.""?",False, +21038220,Mannitol exacerbates intracranial hypertension,823,Does a bolus of mannitol initially aggravate intracranial hypertension?,"Is the triple ""Mannitol exacerbates intracranial hypertension"" supported by the sentence: ""Does a bolus of mannitol initially aggravate intracranial hypertension?""?",False, +23554906,Mannitol predisposes brain injury,824,"This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.","Is the triple ""Mannitol predisposes brain injury"" supported by the sentence: ""This study investigated the effect of equiosmolar doses of 7.5% hypertonic saline (HTS) and 20% mannitol on intraoperative cerebral oxygenation and metabolic status, systemic hemodynamics, brain relaxation, markers of cerebral injury, and perioperative craniotomy outcomes.""?",False, +23171283,Mannitol predisposes acute kidney failure,825,"In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).","Is the triple ""Mannitol predisposes acute kidney failure"" supported by the sentence: ""In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p < 0.001).""?",False, +15337034,Mannitol predisposes brain edema,826,D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.,"Is the triple ""Mannitol predisposes brain edema"" supported by the sentence: ""D-Mannitol produced by C. neoformans may also contribute to brain edema and interfere with phagocyte killing by scavenging hydroxyl radicals.""?",False, +9368450,Mannitol predisposes injury,827,"Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.","Is the triple ""Mannitol predisposes injury"" supported by the sentence: ""Plasma DAO activity, D-lactate content, intestinal pHi and urine L/M may be sensitive markers of intestinal mechanical injury, and glutamine may protect against intestinal barrier dysfunction after severe trauma.""?",False, +25560945,Artesunic acid affects neoplasm,828,Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity.""?",False, +20380317,Artesunic acid affects neoplasm,829,Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.,"Is the triple ""Artesunic acid affects neoplasm"" supported by the sentence: ""Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.""?",False, +17022154,Artesunic acid affects cytomegalovirus infection,830,"OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.","Is the triple ""Artesunic acid affects cytomegalovirus infection"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.""?",False, +15447136,Artesunic acid affects malaria,831,BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.,"Is the triple ""Artesunic acid affects malaria"" supported by the sentence: ""BACKGROUND: Artesunate derivative drugs are newly introduced antimalaria drugs developed in response to the increasing drug resistance malaria spread.""?",False, +14695052,Artesunic acid affects Fever,832,"In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.","Is the triple ""Artesunic acid affects Fever"" supported by the sentence: ""In CH(3)OH, only azithromycin retention was dramatically altered depending on the [triethylamine]/[formic acid] ratio and on the temperature, whereas in CH(3)CN, azithromycin, artesunate, artemisinin and dihydroartemisinin retentions decreased with the temperature increase whatever the organic modifier ratio.""?",False, +9350747,Artesunic acid affects Plasmodium falciparum malaria,833,The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.,"Is the triple ""Artesunic acid affects Plasmodium falciparum malaria"" supported by the sentence: ""The favourable results with quinine-clindamycin mean that there is a useful back-up treatment for women with falciparum malaria who experience quinine and artesunate failures in pregnancy.""?",False, +19053159,Artesunic acid disrupts Plasmodium falciparum malaria,834,"BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.","Is the triple ""Artesunic acid disrupts Plasmodium falciparum malaria"" supported by the sentence: ""BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.""?",False, +17269195,Artesunic acid disrupts neoplasm,835,The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.,"Is the triple ""Artesunic acid disrupts neoplasm"" supported by the sentence: ""The inhibitory effect of artesunate on the tumor of the mouse model as well as ICAM-1 and MMP-9 protein expressions were determined by Western blot.""?",False, +16806460,Artesunic acid disrupts malaria,836,"CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.","Is the triple ""Artesunic acid disrupts malaria"" supported by the sentence: ""CONCLUSIONS: Despite the emergence of resistance to artesunate in P. falciparum, the strategy of EDT with artemisinin-based combination treatments has been associated with a reduction in malaria in the migrant population living on the Thai-Myanmar border.""?",False, +10013375,Artesunic acid prevents schistosomiasis,837,CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.,"Is the triple ""Artesunic acid prevents schistosomiasis"" supported by the sentence: ""CONCLUSION: Artesunate is highly effective and safe for the prevention of schistosomiasis.""?",False, +8540473,Artesunic acid prevents malaria,838,"INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.","Is the triple ""Artesunic acid prevents malaria"" supported by the sentence: ""INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.""?",False, +16567243,Artesunic acid predisposes malaria,839,"We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.","Is the triple ""Artesunic acid predisposes malaria"" supported by the sentence: ""We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe malaria.""?",False, +27639365,Artemether affects Fever,840,RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.,"Is the triple ""Artemether affects Fever"" supported by the sentence: ""RESULTS: Artemether produced a significantly more rapid reduction of parasitemia and fever than sulfadoxine-pyrimethamine.""?",False, +25565511,Artemether affects malaria,841,Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.,"Is the triple ""Artemether affects malaria"" supported by the sentence: ""Artemether is an important drug for malaria and several studies have indicated that it also exhibits anti- T. gondii activity.""?",False, +19253720,Artemether prevents malaria,842,New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.,"Is the triple ""Artemether prevents malaria"" supported by the sentence: ""New drugs such as intravenous artesunate (AS) and intramuscular artemether (AM) are improving outcomes and decreasing malaria deaths.""?",False, +10002115,Artemether prevents urinary schistosomiasis,843,"Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.","Is the triple ""Artemether prevents urinary schistosomiasis"" supported by the sentence: ""Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.""?",False, +8716445,Isoproterenol causes atrial fibrillation,844,"A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).","Is the triple ""Isoproterenol causes atrial fibrillation"" supported by the sentence: ""A malignant form of the condition was defined as the demonstration of two abnormalities: rapid conduction in the bundle of Kent (over 240/min) under basal conditions or over 300/min after Isoprenaline, and if it induced sustained atrial fibrillation (> 1 min).""?",False, +25912644,Isoproterenol affects obstructive lung disease,845,The effect of isoproterenol on airway obstruction in cystic fibrosis.,"Is the triple ""Isoproterenol affects obstructive lung disease"" supported by the sentence: ""The effect of isoproterenol on airway obstruction in cystic fibrosis.""?",False, +24900253,Isoproterenol affects obesity disorder,846,"OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.","Is the triple ""Isoproterenol affects obesity disorder"" supported by the sentence: ""OBJECTIVES: To examine the effects of Isoprenaline (ISO) on obesity and diabesity on ventricular myocyte shortening and Ca 2+ transport in Zucker fatty (ZF), Zucker diabetic fatty (ZDF) in comparison to Zucker lean (ZL) rats.""?",False, +9298156,Isoproterenol affects atrial fibrillation,847,[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].,"Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""[Isoproterenol potentiates atrial fibrillation induced by acetylcholine].""?",False, +7542857,Isoproterenol affects atrial fibrillation,848,"OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.","Is the triple ""Isoproterenol affects atrial fibrillation"" supported by the sentence: ""OBJECTIVES: (1) To investigate the electrophysiological effects of flecainide and propafenone during atrial fibrillation, and their relation to arrhythmia termination; (2) to investigate the effects of isoprenaline on atrial fibrillation in basal conditions and during treatment with class 1C drugs to evaluate the role of adrenergic stimulation on proarrhythmic events occurring during this treatment.""?",False, +26721271,Isoproterenol disrupts obesity disorder,849,"In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.","Is the triple ""Isoproterenol disrupts obesity disorder"" supported by the sentence: ""In conclusion, although the thermogenic response to Iso was similar in lean and obese subjects, the utilization of fat seems to be impaired in obesity.""?",False, +7635739,Isoproterenol predisposes atrial fibrillation,850,The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.,"Is the triple ""Isoproterenol predisposes atrial fibrillation"" supported by the sentence: ""The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.""?",False, +23874783,Bacitracin A related to pneumonia,851,"These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .","Is the triple ""Bacitracin A related to pneumonia"" supported by the sentence: ""These genes were associated with resistance to bacitracin, most of which were associated with K. pneumonia .""?",False, +26428368,Bacitracin A prevents bacterial infectious disease,852,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Bacitracin A prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, +18829774,Bacitracin A prevents cardiac rhythm disease,853,"The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.","Is the triple ""Bacitracin A prevents cardiac rhythm disease"" supported by the sentence: ""The mean digoxin dose and ED50s, at which arrhythmias first occurred, were significantly (p less than 0.05) reduced by bacitracin and bestatin.""?",False, +16650012,Diflunisal subclass of Diflunisal glucuronide ester,854,"We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.","Is the triple ""Diflunisal subclass of Diflunisal glucuronide ester"" supported by the sentence: ""We have investigated the reactivity of DAG, in purified albumin solutions and plasma from both rat and human sources, along three interrelated pathways: rearrangement via acyl migration to yield positional isomers of DAG, hydrolysis of DAG and/or its isomers to liberate DF, and formation of covalent adducts of DF (via DAG and/or its isomers) with plasma protein.""?",False, +26133976,Diflunisal causes Pain,855,"Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).","Is the triple ""Diflunisal causes Pain"" supported by the sentence: ""Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05).""?",False, +26132411,Diflunisal affects Pain,856,[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].,"Is the triple ""Diflunisal affects Pain"" supported by the sentence: ""[Diflunisal and acetylsalicylic acid: a double-blind study of their effect on postextraction pain].""?",False, +26009871,Diflunisal affects Fever,857,"In contrast, submaximal fever in rabbits was not reduced by diflunisal.","Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""In contrast, submaximal fever in rabbits was not reduced by diflunisal.""?",False, +26009870,Diflunisal affects Fever,858,Effects of diflunisal on fever in the rabbit and the rat.,"Is the triple ""Diflunisal affects Fever"" supported by the sentence: ""Effects of diflunisal on fever in the rabbit and the rat.""?",False, +13234484,Diflunisal affects Diflunisal glucuronide ester,859,"Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.","Is the triple ""Diflunisal affects Diflunisal glucuronide ester"" supported by the sentence: ""Total plasma clearance of DF and formation clearances of DF to DF sulphate and 3-hydroxy-DF were little affected by increase of dose from 10 to 50 mg DF/kg, whereas formation clearance of DF to DF acyl glucuronide was increased, but not significantly.""?",False, +14757294,Diflunisal prevents Pain,860,"It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.","Is the triple ""Diflunisal prevents Pain"" supported by the sentence: ""It was a continuation of a previous investigation which tested the effectiveness of diflunisal, administered preoperatively, in reducing periodontal surgical pain.""?",False, +17020332,Salsalate causes Insulin resistance,861,"Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.","Is the triple ""Salsalate causes Insulin resistance"" supported by the sentence: ""Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway.""?",False, +21902985,Salsalate affects diabetes mellitus,862,Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.,"Is the triple ""Salsalate affects diabetes mellitus"" supported by the sentence: ""Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats.A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide.""?",False, +25541729,Salsalate disrupts Insulin resistance,863,Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.,"Is the triple ""Salsalate disrupts Insulin resistance"" supported by the sentence: ""Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats.""?",False, +19533984,Salsalate prevents diabetes mellitus,864,"Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.","Is the triple ""Salsalate prevents diabetes mellitus"" supported by the sentence: ""Salsalate may inform new therapeutic approaches for diabetes prevention, but renal safety may limit clinical utility.""?",False, +26431050,Sodium salicylate causes Fever,865,"Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.","Is the triple ""Sodium salicylate causes Fever"" supported by the sentence: ""Hypothalamic sodium salicylate infusions produced a lower average fever than control infusions over an initial 5 hour period of infection, reducing average 5 hour fevers from 1.56 degrees C to 0.72 degrees C.""?",False, +11882723,Sodium salicylate affects Fever,866,A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""A study was set up to investigate the influence of sodium salicylate on fever and acute phase reaction after lipopolysaccharide (LPS) injection in broiler chickens.""?",False, +9968696,Sodium salicylate affects Fever,867,The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).,"Is the triple ""Sodium salicylate affects Fever"" supported by the sentence: ""The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP).""?",False, +15893532,Sodium salicylate predisposes Pain,868,Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.,"Is the triple ""Sodium salicylate predisposes Pain"" supported by the sentence: ""Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.""?",False, +7201382,Aspirin subclass of Salicylic Acid,869,"The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.","Is the triple ""Aspirin subclass of Salicylic Acid"" supported by the sentence: ""The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied.""?",False, +26818861,Aspirin related to myocardial infarction,870,Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.,"Is the triple ""Aspirin related to myocardial infarction"" supported by the sentence: ""Both aspirin and heparin have proven value in reducing the incidence of myocardial infarction and death in unstable angina.""?",False, +26532873,Aspirin related to classic familial adenomatous polyposis,871,The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.,"Is the triple ""Aspirin related to classic familial adenomatous polyposis"" supported by the sentence: ""The protocol for a European double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: the CAPP study.""?",False, +26329928,Aspirin related to type 2 diabetes mellitus,872,Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.,"Is the triple ""Aspirin related to type 2 diabetes mellitus"" supported by the sentence: ""Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.""?",False, +26168722,Aspirin related to Inflammation,873,"The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.","Is the triple ""Aspirin related to Inflammation"" supported by the sentence: ""The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation.""?",False, +24076103,Aspirin related to Hemorrhage,874,"Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.","Is the triple ""Aspirin related to Hemorrhage"" supported by the sentence: ""Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events.""?",False, +20241570,Aspirin related to Pain,875,Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.,"Is the triple ""Aspirin related to Pain"" supported by the sentence: ""Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect.""?",False, +18524506,Aspirin related to cataract,876,Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.,"Is the triple ""Aspirin related to cataract"" supported by the sentence: ""Systemic aspirin and systemic vitamin E in senile cataracts: cataract V.""?",False, +18008074,Aspirin related to diabetes mellitus,877,"It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).","Is the triple ""Aspirin related to diabetes mellitus"" supported by the sentence: ""It is recommended to prescribe the combination of aspirin and low-molecular-weight heparin when APS (grade A), glycemic control in diabetes (grade A), L-Thyroxine in case of hypothyroidism (grade A) or the presence of thyroid antibodies (grade B), bromocriptine if hyperprolactinemia (grade B), a substitution for vitamin deficiency or hyperhomocysteinemia (grade C), sectionning a uterine septum (grade C) and treating an uterine acquired abnormality (grade C).""?",False, +17483160,Aspirin related to mucocutaneous lymph node syndrome,878,We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.,"Is the triple ""Aspirin related to mucocutaneous lymph node syndrome"" supported by the sentence: ""We assessed whether the addition of infliximab to standard therapy (intravenous immunoglobulin and aspirin) in acute Kawasaki disease reduces the rate of treatment resistance.""?",False, +16078277,Aspirin related to preeclampsia,879,Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.,"Is the triple ""Aspirin related to preeclampsia"" supported by the sentence: ""Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.""?",False, +15283505,Aspirin related to thrombotic disease,880,"The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.","Is the triple ""Aspirin related to thrombotic disease"" supported by the sentence: ""The filter blockage is not influenced by aspirin, heparin and ticlopidine and so involves a different mechanism from the aspirin sensitive mechanisms involved in clinical thrombosis prevention in vivo in man.""?",False, +13829413,Aspirin related to retinal vein occlusion,881,Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.,"Is the triple ""Aspirin related to retinal vein occlusion"" supported by the sentence: ""Dalteparin versus aspirin in recent-onset branch retinal vein occlusion: a randomized clinical trial.""?",False, +13174915,Aspirin related to ST-elevation myocardial infarction,882,"The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.","Is the triple ""Aspirin related to ST-elevation myocardial infarction"" supported by the sentence: ""The totality of trial data suggest that the combination of a fibrinolytic, aspirin, clopidogrel, and ENOX offers an attractive pharmacologic reperfusion strategy in STEMI.""?",False, +12865539,Aspirin related to cardiovascular disorder,883,"METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.","Is the triple ""Aspirin related to cardiovascular disorder"" supported by the sentence: ""METHODS: Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992.""?",False, +12749655,Aspirin related to Salicylic Acid,884,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, +12502970,Aspirin related to coronary artery disorder,885,Low-dose aspirin and heparin in unstable coronary artery disease.,"Is the triple ""Aspirin related to coronary artery disorder"" supported by the sentence: ""Low-dose aspirin and heparin in unstable coronary artery disease.""?",False, +10635434,Aspirin related to rheumatic heart disease,886,A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.,"Is the triple ""Aspirin related to rheumatic heart disease"" supported by the sentence: ""A comparison of the effect of prednisone and acetylsalicylic acid on the incidence of residual rheumatic heart disease.""?",False, +10534181,Aspirin related to osteoarthritis,887,"A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.","Is the triple ""Aspirin related to osteoarthritis"" supported by the sentence: ""A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.""?",False, +10473195,Aspirin related to asthma,888,"Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.","Is the triple ""Aspirin related to asthma"" supported by the sentence: ""Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.""?",False, +9315521,Aspirin related to atrial fibrillation,889,"In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.","Is the triple ""Aspirin related to atrial fibrillation"" supported by the sentence: ""In contrast, over one-third of the cardiologists went as far as to give warfarin to a low-risk patient and they were more likely to overestimate the reported benefit of aspirin and warfarin in AF.""?",False, +8718389,Aspirin related to stroke disorder,890,Heparin and aspirin in stroke.,"Is the triple ""Aspirin related to stroke disorder"" supported by the sentence: ""Heparin and aspirin in stroke.""?",False, +8430499,Aspirin related to Ischemic stroke,891,Heparin versus aspirin in ischaemic stroke.,"Is the triple ""Aspirin related to Ischemic stroke"" supported by the sentence: ""Heparin versus aspirin in ischaemic stroke.""?",False, +7718877,Aspirin related to acute coronary syndrome,892,"In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.","Is the triple ""Aspirin related to acute coronary syndrome"" supported by the sentence: ""In addition, their use in conjunction with ASA and heparin in the acute coronary syndrome led to further significant reduction of cardiovascular events in several studies.""?",False, +8745735,Aspirin related to Salicylic Acid,893,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin related to Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, +12749656,Aspirin close match Salicylic Acid,894,Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.,"Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.""?",False, +8745736,Aspirin close match Salicylic Acid,895,"The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.","Is the triple ""Aspirin close match Salicylic Acid"" supported by the sentence: ""The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.""?",False, +10716638,Aspirin coexists with Salicylic Acid,896,An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.,"Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml.""?",False, +10182446,Aspirin coexists with Salicylic Acid,897,"A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.","Is the triple ""Aspirin coexists with Salicylic Acid"" supported by the sentence: ""A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium.""?",False, +8959647,Aspirin derives from Salicylic Acid,898,Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.,"Is the triple ""Aspirin derives from Salicylic Acid"" supported by the sentence: ""Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis.""?",False, +7421635,Aspirin physically interacts with Salicylic Acid,899,"Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans.""?",False, +9047883,Aspirin physically interacts with Salicylic Acid,900,"Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.","Is the triple ""Aspirin physically interacts with Salicylic Acid"" supported by the sentence: ""Salicylic acid is responsible for the anti-inflammatory action of aspirin, and may cause the reduced risk of colorectal cancer observed in those who take aspirin.""?",False, +27550629,Aspirin causes transient ischemic attack,901,"In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).","Is the triple ""Aspirin causes transient ischemic attack"" supported by the sentence: ""In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2).""?",False, +27093984,Aspirin causes Sepsis,902,Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).,"Is the triple ""Aspirin causes Sepsis"" supported by the sentence: ""Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone).""?",False, +26941889,Aspirin causes colonic neoplasm,903,"Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.","Is the triple ""Aspirin causes colonic neoplasm"" supported by the sentence: ""Although the precise mechanisms of aspirin-induced colon tumor inhibition remain to be determined, it is likely that the effect may be mediated through the modulation of prostaglandin synthesis.""?",False, +26621273,Aspirin causes diabetic retinopathy,904,"Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.","Is the triple ""Aspirin causes diabetic retinopathy"" supported by the sentence: ""Aspirin induced the expression of HLA-DR in HT29 cells, a cell line not expressing constitutively HLA-DR.""?",False, +25682183,Aspirin causes Toothache,905,The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.,"Is the triple ""Aspirin causes Toothache"" supported by the sentence: ""The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain.""?",False, +24276147,Aspirin causes osteoarthritis,906,"The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.","Is the triple ""Aspirin causes osteoarthritis"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.""?",False, +23603605,Aspirin causes infertility disorder,907,"Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.","Is the triple ""Aspirin causes infertility disorder"" supported by the sentence: ""Although the extent of infertility due to ASAs alone is not very clear, data indicates that about 8-10% of infertile patients have immunological infertility DESIGN: This retrospective study includes all infertile male patients (n = 2,258) who underwent MAR (Mixed Antiglobulin Reaction) test and urologic examination from 2000 to 2020.""?",False, +22149437,Aspirin causes myocardial infarction,908,"In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.","Is the triple ""Aspirin causes myocardial infarction"" supported by the sentence: ""In terms of specific effectiveness indicators such as stroke, MI, and stent thrombosis, the results of TA and CA groups in the European, American, and Asian populations are not consistent.""?",False, +21269587,Aspirin causes preeclampsia,909,This review article will contribute to the in-depth understanding of LDA-induced PE prevention.,"Is the triple ""Aspirin causes preeclampsia"" supported by the sentence: ""This review article will contribute to the in-depth understanding of LDA-induced PE prevention.""?",False, +21190178,Aspirin causes Varicose Ulcer,910,Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.,"Is the triple ""Aspirin causes Varicose Ulcer"" supported by the sentence: ""Massive esophageal bleeding in long-standing achalasia complicated by esophageal carcinoma and aspirin-induced stasis ulcer: Case report.""?",False, +20967677,Aspirin causes cerebral infarction,911,"The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.","Is the triple ""Aspirin causes cerebral infarction"" supported by the sentence: ""The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits.""?",False, +20453125,Aspirin causes squamous cell carcinoma,912,"Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.","Is the triple ""Aspirin causes squamous cell carcinoma"" supported by the sentence: ""Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC.""?",False, +20257764,Aspirin causes vascular disorder,913,Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.,"Is the triple ""Aspirin causes vascular disorder"" supported by the sentence: ""Treatment with aspirin or cilostazol was started 1 day after aneurysm induction.""?",False, +18467493,Aspirin causes periodontitis,914,Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.,"Is the triple ""Aspirin causes periodontitis"" supported by the sentence: ""Applying aspirin before or after induction of periodontitis did not have a significant effect on the parameters measured.""?",False, +18133593,Aspirin causes acute lung injury,915,Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.,"Is the triple ""Aspirin causes acute lung injury"" supported by the sentence: ""Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.""?",False, +17905974,Aspirin causes mucocutaneous lymph node syndrome,916,Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.,"Is the triple ""Aspirin causes mucocutaneous lymph node syndrome"" supported by the sentence: ""Considering the downregulation of Th17 and its related cytokines with aspirin and intravenous immunoglobulin therapy implies the probable role of Th17 in KD pathogenesis.""?",False, +16266546,Aspirin causes cardiovascular disorder,917,BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.,"Is the triple ""Aspirin causes cardiovascular disorder"" supported by the sentence: ""BACKGROUND: Aspirin use for the primary prevention of cardiovascular disease (CVD) is controversial because of the need to balance the risk of major bleeding events caused by aspirin with the benefit of CVD events prevented by aspirin.""?",False, +15908394,Aspirin causes arthritic joint disease,918,Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.,"Is the triple ""Aspirin causes arthritic joint disease"" supported by the sentence: ""Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis.""?",False, +15782733,Aspirin causes ulcerative colitis,919,Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.,"Is the triple ""Aspirin causes ulcerative colitis"" supported by the sentence: ""Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European prospective cohort study.""?",False, +15251529,Aspirin causes myocardial ischemia,920,Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.,"Is the triple ""Aspirin causes myocardial ischemia"" supported by the sentence: ""Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin.""?",False, +15022291,Aspirin causes pneumonia,921,"BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.","Is the triple ""Aspirin causes pneumonia"" supported by the sentence: ""BACKGROUND: Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing.""?",False, +14953515,Aspirin causes diabetes mellitus,922,"Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.","Is the triple ""Aspirin causes diabetes mellitus"" supported by the sentence: ""Four weeks after diabetes induction rats were treated with minocycline (50 mg/kg, p.o.) per se, aspirin (50 mg/kg, p.o.) per se, or minocycline in combination with aspirin for a period of four weeks.""?",False, +14693157,Aspirin causes atrial fibrillation,923,"I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.","Is the triple ""Aspirin causes atrial fibrillation"" supported by the sentence: ""I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin.""?",False, +14660024,Aspirin causes ischemic disease,924,C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.,"Is the triple ""Aspirin causes ischemic disease"" supported by the sentence: ""C57BL/6J mice were treated with aspirin or etodolac for twenty-eight days after induction of ischemia.""?",False, +14296178,Aspirin causes type 2 diabetes mellitus,925,Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.,"Is the triple ""Aspirin causes type 2 diabetes mellitus"" supported by the sentence: ""Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers.""?",False, +13914591,Aspirin causes digestive system disorder,926,"Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.","Is the triple ""Aspirin causes digestive system disorder"" supported by the sentence: ""Low-dose aspirin-induced gastrointestinal diseases: past, present, and future.""?",False, +13814866,Aspirin causes Fever,927,Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.,"Is the triple ""Aspirin causes Fever"" supported by the sentence: ""Its antipyretic activity is greater than either aspirin or paracetamol in tests inducing pyrexia with yeast of 'E' pyrogen in rats and rabbits.""?",False, +13639281,Aspirin causes acute coronary syndrome,928,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes acute coronary syndrome"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, +13639280,Aspirin causes Ischemic stroke,929,"BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.","Is the triple ""Aspirin causes Ischemic stroke"" supported by the sentence: ""BACKGROUND: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.""?",False, +13405854,Aspirin causes hypertensive disorder,930,"The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.","Is the triple ""Aspirin causes hypertensive disorder"" supported by the sentence: ""The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension.""?",False, +13278968,Aspirin causes adult acute respiratory distress syndrome,931,Aspirin-induced non-cardiogenic pulmonary edema.,"Is the triple ""Aspirin causes adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin-induced non-cardiogenic pulmonary edema.""?",False, +11251562,Aspirin causes Pain,932,The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).,"Is the triple ""Aspirin causes Pain"" supported by the sentence: ""The percent maximum protection against thermal pain produced by Aspirin (71.43%) was twice as high as that produced by the most active of the four derivatives (43.65%).""?",False, +10850020,Aspirin causes migraine disorder,933,"When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.","Is the triple ""Aspirin causes migraine disorder"" supported by the sentence: ""When other possible causes of stroke were excluded, the association of migraine with the protracted vasoconstriction of ergotamine, able per se to damage the capillary endothelium, and an altered local hemostasis induced by aspirin remained as the most probable mechanism of brain bleeding.""?",False, +10555051,Aspirin causes duodenal ulcer,934,"As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.","Is the triple ""Aspirin causes duodenal ulcer"" supported by the sentence: ""As to the anti-lesion effects on HCl.aspirin-induced gastric lesions or mepirizole-induced duodenal ulcers, IGN-2098 was 8.1 or 14.8 times more potent than roxatidine, respectively.""?",False, +9350599,Aspirin causes active peptic ulcer disease,935,DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.,"Is the triple ""Aspirin causes active peptic ulcer disease"" supported by the sentence: ""DATA SYNTHESIS: Aspirin products are known to cause GI bleeding.""?",False, +9238263,Aspirin causes blood coagulation disease,936,"An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.","Is the triple ""Aspirin causes blood coagulation disease"" supported by the sentence: ""An abnormal release of platelet adenosine diphosphate (ADP), as seen after intake of acetylsalicylic acid, was demonstrated to be the cause of a clotting disorder in two identical female twins.""?",False, +8683872,Aspirin causes stroke disorder,937,"MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.","Is the triple ""Aspirin causes stroke disorder"" supported by the sentence: ""MAIN OUTCOME MEASURES: Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages.""?",False, +8518235,Aspirin causes peptic ulcer disease,938,Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.,"Is the triple ""Aspirin causes peptic ulcer disease"" supported by the sentence: ""Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.""?",False, +8466167,Aspirin causes Headache,939,(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.,"Is the triple ""Aspirin causes Headache"" supported by the sentence: ""(3) The addition of dipyridamole to aspirin can cause headache and diarrhoea.""?",False, +8232293,Aspirin causes Hemorrhage,940,"The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.","Is the triple ""Aspirin causes Hemorrhage"" supported by the sentence: ""The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002.""?",False, +7594346,Aspirin causes asthma,941,LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.,"Is the triple ""Aspirin causes asthma"" supported by the sentence: ""LTC4S is profoundly overexpressed in the aspirin-induced asthmatic phenotype and correlates with overproduction of cysteinyl LTs and bronchial hyperreactivity to lysine aspirin.""?",False, +7353622,Aspirin causes gastric ulcer,942,BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.,"Is the triple ""Aspirin causes gastric ulcer"" supported by the sentence: ""BACKGROUND: Gastric ulceration induced by aspirin and by non-steroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem.""?",False, +7227553,Aspirin causes injury,943,"Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.","Is the triple ""Aspirin causes injury"" supported by the sentence: ""Plain aspirin caused a dose-dependent mucosal injury, with two (median, IQR 0-7) gastric erosions after five days of plain aspirin 75 mg, and 18 (2-26) after five days of plain aspirin 300 mg.""?",False, +26773149,Aspirin affects atrial fibrillation,944,Further studies are needed to clarify the role of aspirin in atrial fibrillation.,"Is the triple ""Aspirin affects atrial fibrillation"" supported by the sentence: ""Further studies are needed to clarify the role of aspirin in atrial fibrillation.""?",False, +26425353,Aspirin affects atherosclerosis,945,Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques.""?",False, +26396469,Aspirin affects Dysmenorrhea,946,The effect of aspirin on dysmenorrhea in adolescents.,"Is the triple ""Aspirin affects Dysmenorrhea"" supported by the sentence: ""The effect of aspirin on dysmenorrhea in adolescents.""?",False, +25760183,Aspirin affects thrombophilia due to thrombin defect,947,Effect of aspirin on postoperative venous thrombosis.,"Is the triple ""Aspirin affects thrombophilia due to thrombin defect"" supported by the sentence: ""Effect of aspirin on postoperative venous thrombosis.""?",False, +24559876,Aspirin affects coronary artery disorder,948,"CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.","Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""CONCLUSIONS: The protective potential of low-dose ASA for all-cause dementia, AD, and VD seems to strongly depend on pre-existing CHD and the willingness of patients to take it for a minimum of ten years.""?",False, +23119254,Aspirin affects brain aneurysm,949,Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""Prospective randomised studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.""?",False, +21758599,Aspirin affects brain aneurysm,950,CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.,"Is the triple ""Aspirin affects brain aneurysm"" supported by the sentence: ""CONCLUSIONS: The study results establish a correlation between use of ASA daily for >= 6 months and significant decreases in wall enhancement of UIAs on HR-VWI.""?",False, +21116359,Aspirin affects major depressive disorder,951,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, +21116358,Aspirin affects schizophrenia,952,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Aspirin affects schizophrenia"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, +21031382,Aspirin affects neoplasm,953,"Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.""?",False, +20857373,Aspirin affects melanoma,954,"It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.","Is the triple ""Aspirin affects melanoma"" supported by the sentence: ""It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma.""?",False, +20741170,Aspirin affects fetal growth restriction,955,Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.,"Is the triple ""Aspirin affects fetal growth restriction"" supported by the sentence: ""Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.""?",False, +20453126,Aspirin affects squamous cell carcinoma,956,"To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.","Is the triple ""Aspirin affects squamous cell carcinoma"" supported by the sentence: ""To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin.""?",False, +19190473,Aspirin affects acute lung injury,957,RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.,"Is the triple ""Aspirin affects acute lung injury"" supported by the sentence: ""RESULTS: Aspirin both before and after LPS inhalation reduced neutrophil influx into the lung and lung permeability indicating the protective role of Aspirin in ALI.""?",False, +18874269,Aspirin affects preeclampsia,958,Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.,"Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia.""?",False, +18830463,Aspirin affects Varicose Ulcer,959,"To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.","Is the triple ""Aspirin affects Varicose Ulcer"" supported by the sentence: ""To date, the impact of aspirin on VLUs has been examined by only two randomised clinical trials, both with a small number of participants.""?",False, +18706529,Aspirin affects mucocutaneous lymph node syndrome,960,"Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.","Is the triple ""Aspirin affects mucocutaneous lymph node syndrome"" supported by the sentence: ""Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear.""?",False, +18617993,Aspirin affects Sepsis,961,"This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.","Is the triple ""Aspirin affects Sepsis"" supported by the sentence: ""This review will discuss the role of the platelet, the mechanisms of action of aspirin in sepsis and ARDS, and aspirin as a potential therapy in treating sepsis and ARDS.""?",False, +18348076,Aspirin affects Headache,962,"We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).","Is the triple ""Aspirin affects Headache"" supported by the sentence: ""We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TTH), and migraine + TTH (MigTTH).""?",False, +18344374,Aspirin affects bone fracture,963,This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.,"Is the triple ""Aspirin affects bone fracture"" supported by the sentence: ""This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged >=70 years recruited in Australia.""?",False, +18277701,Aspirin affects adult acute respiratory distress syndrome,964,"Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.","Is the triple ""Aspirin affects adult acute respiratory distress syndrome"" supported by the sentence: ""Aspirin therapy has recently been shown to reduce the risk of developing ARDS, but the effect of aspirin on established ARDS is unknown.""?",False, +18092588,Aspirin affects Fever,965,"Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Clearly, at low doses aspirin and most of the newer NSAIDs inhibit the biosynthesis of PGs from arachidonic acid, and stable PGs have been shown to mediate fever, hyperalgesia, vasodilation (edema), and several interleukin-1-dependent responses.""?",False, +17810437,Aspirin affects migraine disorder,966,"Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.","Is the triple ""Aspirin affects migraine disorder"" supported by the sentence: ""Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera.""?",False, +16655533,Aspirin affects stroke disorder,967,Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events.""?",False, +16466986,Aspirin affects myocardial ischemia,968,Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""Removing aspirin from the combination decreased preventable IHD deaths by 15% under the additive assumption (5600 deaths) and by 21% under the multiplicative assumption (6800 deaths) and reduced preventable stroke deaths under both additive and multiplicative assumptions by 3% (300 deaths).""?",False, +16123563,Aspirin affects digestive system disorder,969,[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].,"Is the triple ""Aspirin affects digestive system disorder"" supported by the sentence: ""[Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin].""?",False, +15829936,Aspirin affects hypertriglyceridemia,970,Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.,"Is the triple ""Aspirin affects hypertriglyceridemia"" supported by the sentence: ""Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.""?",False, +15667690,Aspirin affects hepatocellular carcinoma,971,Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.,"Is the triple ""Aspirin affects hepatocellular carcinoma"" supported by the sentence: ""Few studies have been designed to explore the effect of aspirin on hepatocellular carcinoma.""?",False, +15311732,Aspirin affects periodontitis,972,"METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.","Is the triple ""Aspirin affects periodontitis"" supported by the sentence: ""METHODS: To measure the effects on periodontitis, ligatures were placed around first molars, and aspirin (Asp, 30 mg/kg) or clopidogrel (Clo, 75 mg/kg) was given intragastrically once daily for 15 days.""?",False, +15094783,Aspirin affects diabetic retinopathy,973,Effects of aspirin treatment on diabetic retinopathy.,"Is the triple ""Aspirin affects diabetic retinopathy"" supported by the sentence: ""Effects of aspirin treatment on diabetic retinopathy.""?",False, +13831910,Aspirin affects gastric ulcer,974,The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.,"Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.""?",False, +13734334,Aspirin affects Pregnancy,975,"There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.","Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""There is a lot of debate on the administration of low-dose aspirin, estrogen, vaginal sildenafil citrate, pentoxifylline, vitamin E, and gonadotropin-releasing hormone agonist for the management of thin endometrium with an aim to increase the pregnancy and implantation rates in assisted reproductive technology cycles.""?",False, +13647977,Aspirin affects neoplasm,976,"We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.","Is the triple ""Aspirin affects neoplasm"" supported by the sentence: ""We also studied the effect on tumour development of three inhibitors of prostaglandin synthesis: indomethacin, piroxicam and aspirin.""?",False, +13624111,Aspirin affects pneumonia,977,OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.,"Is the triple ""Aspirin affects pneumonia"" supported by the sentence: ""OBJECTIVE: We sought to establish the effect of aspirin on pulmonary inflammation and function in patients with persistent asthma.""?",False, +13559011,Aspirin affects type 2 diabetes mellitus,978,"Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.","Is the triple ""Aspirin affects type 2 diabetes mellitus"" supported by the sentence: ""Furthermore, some reports show a decreased sensitivity to the platelet antiaggregating effect of acetylsalicylic acid in obesity and type 2 diabetes mellitus.""?",False, +13493823,Aspirin affects thrombotic disease,979,Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.,"Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""Aspirin is prescribed with increasing frequency to reduce the risk of maternal thrombosis and reduce the risk of miscarriage and poor pregnancy outcome.""?",False, +12884495,Aspirin affects duodenal ulcer,980,"Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.","Is the triple ""Aspirin affects duodenal ulcer"" supported by the sentence: ""Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.""?",False, +12815469,Aspirin affects atherosclerosis,981,Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.,"Is the triple ""Aspirin affects atherosclerosis"" supported by the sentence: ""Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits.""?",False, +12769418,Aspirin affects active peptic ulcer disease,982,The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""The risk of NSAID-related gastrointestinal bleeding is augmented by concomitant low-dose aspirin and could approach double the risk of NSAID use alone.""?",False, +12607959,Aspirin affects plasma cell myeloma,983,Does low-dose aspirin have antineoplastic effects in multiple myeloma?,"Is the triple ""Aspirin affects plasma cell myeloma"" supported by the sentence: ""Does low-dose aspirin have antineoplastic effects in multiple myeloma?""?",False, +12446363,Aspirin affects hypertensive disorder,984,Diabetes mellitus and hypertension are relative risk factors of AR and ASR.,"Is the triple ""Aspirin affects hypertensive disorder"" supported by the sentence: ""Diabetes mellitus and hypertension are relative risk factors of AR and ASR.""?",False, +12124867,Aspirin affects heart disorder,985,Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.,"Is the triple ""Aspirin affects heart disorder"" supported by the sentence: ""Racial differences in the use of aspirin: an important tool for preventing heart disease and stroke.""?",False, +11661767,Aspirin affects peptic ulcer disease,986,"CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: Gastric epithelial anti-microbial peptides are influenced by anatomical site, grade of gastritis, peptic ulceration, and can be modulated by aspirin.""?",False, +11474111,Aspirin affects diabetes mellitus,987,We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.,"Is the triple ""Aspirin affects diabetes mellitus"" supported by the sentence: ""We also present recommendations for the use of aspirin in the diabetic population and the current guidelines put forth by the American Heart Association and by the American Diabetes Association.""?",False, +11357781,Aspirin affects ischemic disease,988,Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.,"Is the triple ""Aspirin affects ischemic disease"" supported by the sentence: ""Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis.""?",False, +11341534,Aspirin affects ulcer disease,989,"Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.""?",False, +11135514,Aspirin affects cerebrovascular disorder,990,Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.,"Is the triple ""Aspirin affects cerebrovascular disorder"" supported by the sentence: ""Measurement of the antiplatelet effects of aspirin in cerebrovascular disease.""?",False, +10875862,Aspirin affects acquired polycythemia vera,991,"Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.","Is the triple ""Aspirin affects acquired polycythemia vera"" supported by the sentence: ""Gianni Tognoni discusses the role of aspirin therapy in PV based on the recently completed European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) Study, a multi-country, multicenter project aimed at describing the natural history of PV as well as the efficacy of low-dose aspirin.""?",False, +10830878,Aspirin affects Inflammation,992,"These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""These studies indicated a deleterious effect of NSAIDs and aspirin in this setting, demonstrating a 2- to 3-fold increase in inflammation, myocytes necrosis and even mortality when compared with placebo.""?",False, +10337669,Aspirin affects colorectal neoplasm,993,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Aspirin affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, +10331252,Aspirin affects peptic ulcer disease,994,"Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.","Is the triple ""Aspirin affects peptic ulcer disease"" supported by the sentence: ""Unwanted effects of aspirin include stomach upsets, activation of peptic ulcers, an increased tendency to bruising, allergic reactions and increased risk of major gastrointestinal and other bleeding, including intracranial haemorrhage.""?",False, +10226347,Aspirin affects thrombophilia,995,"Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.","Is the triple ""Aspirin affects thrombophilia"" supported by the sentence: ""Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts.""?",False, +10082315,Aspirin affects Pain,996,"Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.","Is the triple ""Aspirin affects Pain"" supported by the sentence: ""Aspirin-responsive painful red, blue, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia.""?",False, +10068618,Aspirin affects adenoma,997,CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.,"Is the triple ""Aspirin affects adenoma"" supported by the sentence: ""CONCLUSIONS: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.""?",False, +9766251,Aspirin affects injury,998,Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.,"Is the triple ""Aspirin affects injury"" supported by the sentence: ""Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury.""?",False, +9581221,Aspirin affects cataract,999,"Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.","Is the triple ""Aspirin affects cataract"" supported by the sentence: ""Also modification by aspirin, which is known to delay cataract and other diseases, has been investigated.""?",False, +9528323,Aspirin affects asthma,1000,We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).,"Is the triple ""Aspirin affects asthma"" supported by the sentence: ""We described asthma with sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAID).""?",False, +9510044,Aspirin affects transient ischemic attack,1001,This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.,"Is the triple ""Aspirin affects transient ischemic attack"" supported by the sentence: ""This combination of aspirin and extended-release dipyridamole may play a significant role in secondary stroke and TIA prevention.""?",False, +9342553,Aspirin affects Salicylic Acid,1002,"METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""METHODS: Using cultured endothelial cells, we measured the effect of aspirin with different incubative time (4 - 24 h) and different concentration (0.1 - 3 mmol/L), salicylic acid and indomethacin induced ferritin expression by ELISA kit, and observed the change of lactate dehydrogenase (LDH) release rate, malondialdehyde (MDA) and cellular viability after preincubating the cell for 8 h with aspirin on resistance to hydrogen peroxide toxicity.""?",False, +9259288,Aspirin affects Fever,1003,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Aspirin affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, +9203900,Aspirin affects Hypercholesterolemia,1004,This action of aspirin is blunted in hypercholesterolemia.,"Is the triple ""Aspirin affects Hypercholesterolemia"" supported by the sentence: ""This action of aspirin is blunted in hypercholesterolemia.""?",False, +9160463,Aspirin affects gastric ulcer,1005,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.","Is the triple ""Aspirin affects gastric ulcer"" supported by the sentence: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin (IND), ibuprofen and newer cyclooxygenase-2 selective NSAIDs (e.g. celecoxib) delay gastric ulcer healing partly through the inhibition of angiogenesis, but the molecular mechanisms involved are not fully elucidated.""?",False, +9084341,Aspirin affects Ischemic stroke,1006,A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.,"Is the triple ""Aspirin affects Ischemic stroke"" supported by the sentence: ""A reduced Cox proportional-hazards model was developed to test for the effect of aspirin dose on ischemic stroke in predefined subgroups.""?",False, +8650258,Aspirin affects Hemorrhage,1007,"CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.""?",False, +8543326,Aspirin affects active peptic ulcer disease,1008,OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.,"Is the triple ""Aspirin affects active peptic ulcer disease"" supported by the sentence: ""OBJECTIVES: To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.""?",False, +8290962,Aspirin affects ulcer disease,1009,"Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.","Is the triple ""Aspirin affects ulcer disease"" supported by the sentence: ""Third, a mechanism suspected of participating in the pathogenesis; the pathogenesis of drug ulceration is not fully understood but aspirin may be the only one with a body of data to support its ulcerogenic effect.""?",False, +8187935,Aspirin affects injury,1010,"Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.","Is the triple ""Aspirin affects injury"" supported by the sentence: ""Thus, the enhancement of ROS-induced injury by aspirin may be accomplished through diminished gastric mucus synthesis, since mucus is a potent scavenger of ROS.""?",False, +8173134,Aspirin affects thrombotic disease,1011,"These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.","Is the triple ""Aspirin affects thrombotic disease"" supported by the sentence: ""These results showed that: first, the inhibition of the activity of thromboxane A2 by an antagonist was not more important than that by aspirin and second, the thromboxane A2 way was well implicated in the thrombosis in the guinea pig, suggesting that this species was a good model for the study of the mechanisms using the prostaglandins way in arterial thrombosis.""?",False, +8169760,Aspirin affects preeclampsia,1012,"These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.","Is the triple ""Aspirin affects preeclampsia"" supported by the sentence: ""These observations led to the hypotheses that antiplatelet agents, and low dose aspirin in particular, might prevent or delay the development of pre-eclampsia.""?",False, +7935107,Aspirin affects prostate cancer,1013,"Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.","Is the triple ""Aspirin affects prostate cancer"" supported by the sentence: ""Since the age group in which aspirin use has become prevalent is similar to the one presenting with prostate cancer, we decided to examine the potential effects of aspirin on prostate cancer.""?",False, +7920712,Aspirin affects Hemorrhage,1014,"After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""After unstable angina and non-Q-wave myocardial infarction, oral anticoagulant therapy (INR range 2-3) combined with aspirin has been shown to be advantageous over aspirin alone, although at the cost of a slight increase in bleeding.""?",False, +7876600,Aspirin affects Hemorrhage,1015,"CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.","Is the triple ""Aspirin affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding.""?",False, +7820545,Aspirin affects vascular disorder,1016,The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.,"Is the triple ""Aspirin affects vascular disorder"" supported by the sentence: ""The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.""?",False, +7816175,Aspirin affects Pregnancy,1017,L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.,"Is the triple ""Aspirin affects Pregnancy"" supported by the sentence: ""L-arginine transport at the fetal side of human placenta: effect of aspirin in pregnancy.""?",False, +7635677,Aspirin affects myocardial ischemia,1018,We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.,"Is the triple ""Aspirin affects myocardial ischemia"" supported by the sentence: ""We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina.""?",False, +7478885,Aspirin affects coronary artery disorder,1019,Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.,"Is the triple ""Aspirin affects coronary artery disorder"" supported by the sentence: ""Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects.""?",False, +7468514,Aspirin affects stroke disorder,1020,A metaregression analysis of the dose-response effect of aspirin on stroke.,"Is the triple ""Aspirin affects stroke disorder"" supported by the sentence: ""A metaregression analysis of the dose-response effect of aspirin on stroke.""?",False, +7251569,Aspirin affects myocardial infarction,1021,A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.,"Is the triple ""Aspirin affects myocardial infarction"" supported by the sentence: ""A long term (minimum duration 12 months) phase III study (2nd SYMPHONY) is under way to compare the effects of sibrafiban on cardiac events with those of aspirin in patients stabilised after an MI or an episode of unstable angina.""?",False, +7213554,Aspirin affects cardiovascular disorder,1022,"The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.","Is the triple ""Aspirin affects cardiovascular disorder"" supported by the sentence: ""The effects of low-dose aspirin on cardiovascular disease have been tested in randomized trials in 3 types of populations: (1) patients with a history of cardiovascular disease; (2) patients with evolving acute myocardial infarction (MI), and (3) apparently healthy subjects.""?",False, +7156429,Aspirin affects Inflammation,1023,"The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.","Is the triple ""Aspirin affects Inflammation"" supported by the sentence: ""The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor.""?",False, +14159165,Aspirin affects Salicylic Acid,1024,"According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.","Is the triple ""Aspirin affects Salicylic Acid"" supported by the sentence: ""According to the known mechanism that SA interferes with ASA in preventing acetylation of platelet's proteins, an explanation for the low ASA concentration-dependent effects on fibrin network structure may be that fewer molecules of SA-the hydrolytic product of ASA-are generated from lower doses of ASA, which block acetylation of fibrinogen to a smaller extent and thus more significantly impair fibrin formation.""?",False, +27335099,Aspirin disrupts thrombophilia due to thrombin defect,1025,"In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.","Is the triple ""Aspirin disrupts thrombophilia due to thrombin defect"" supported by the sentence: ""In conclusion, low dose aspirin inhibits anastomotic venous thrombosis and improves microcirculatory perfusion in our rat model.""?",False, +24958273,Aspirin disrupts Fever,1026,"In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.","Is the triple ""Aspirin disrupts Fever"" supported by the sentence: ""In 2021, we reached the 50th anniversary of the publication of Sir John Vane's seminal paper in Nature New Biology describing the experiments supporting his mechanistic hypothesis that inhibition of prostaglandin synthesis might explain the main pharmacological effects of aspirin and aspirin-like drugs, that is, reduction in pain, fever and inflammation.""?",False, +24520178,Aspirin disrupts melanoma,1027,"However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).","Is the triple ""Aspirin disrupts melanoma"" supported by the sentence: ""However, aspirin was associated with a reduced risk of incident melanoma amongst individuals with uncontrolled hypertension (blood pressure >=140/90 mmHg; HR=0.63, 95%CI 0.44-0.89), but not in those with controlled hypertension (HR=1.04, 95%CI 0.74-1.46).""?",False, +24047967,Aspirin disrupts cardiovascular disorder,1028,"Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.","Is the triple ""Aspirin disrupts cardiovascular disorder"" supported by the sentence: ""Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit-risk ratios at older ages.""?",False, +22107293,Aspirin disrupts atrial fibrillation,1029,Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.,"Is the triple ""Aspirin disrupts atrial fibrillation"" supported by the sentence: ""Concomitant use of direct oral anticoagulants and aspirin versus direct oral anticoagulants alone in atrial fibrillation and flutter: a retrospective cohort.BACKGROUND: The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied.""?",False, +22100738,Aspirin disrupts fetal growth restriction,1030,"Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.","Is the triple ""Aspirin disrupts fetal growth restriction"" supported by the sentence: ""Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age.""?",False, +22027792,Aspirin disrupts venous thromboembolism,1031,Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.,"Is the triple ""Aspirin disrupts venous thromboembolism"" supported by the sentence: ""Aspirin Is Associated With Reduced Rates of Venous Thromboembolism in Older Patients With Cancer.""?",False, +21434441,Aspirin disrupts thrombophilia,1032,"Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.","Is the triple ""Aspirin disrupts thrombophilia"" supported by the sentence: ""Glucocorticoid administration is a risk factor for thromboembolism in hypercoagulable dogs, and it is unknown if aspirin counteracts glucocorticoid-induced hypercoagulability.""?",False, +20385507,Aspirin disrupts essential thrombocythemia,1033,"However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.","Is the triple ""Aspirin disrupts essential thrombocythemia"" supported by the sentence: ""However, the pharmacodynamics of low-dose aspirin is impaired in ET, reflecting accelerated renewal of platelet cyclooxygenase (COX)-1.""?",False, +19437129,Aspirin disrupts Sepsis,1034,"This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).","Is the triple ""Aspirin disrupts Sepsis"" supported by the sentence: ""This paper describes the rationale and design of the AspiriN To Inhibit SEPSIS (ANTISEPSIS) trial, a substudy of ASPirin in Reducing Events in the Elderly (ASPREE).""?",False, +19421638,Aspirin disrupts pneumonia,1035,"CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.","Is the triple ""Aspirin disrupts pneumonia"" supported by the sentence: ""CONCLUSIONS: These are the first prospective human data indicating that aspirin inhibits pulmonary neutrophilic inflammation, at both low and high doses.""?",False, +19318532,Aspirin disrupts vascular disorder,1036,These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.,"Is the triple ""Aspirin disrupts vascular disorder"" supported by the sentence: ""These adverse effects of aspirin should be weighed against the reductions in vascular disease and cancer.""?",False, +18604728,Aspirin disrupts type 2 diabetes mellitus,1037,"Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.","Is the triple ""Aspirin disrupts type 2 diabetes mellitus"" supported by the sentence: ""Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus.""?",False, +18599969,Aspirin disrupts arthritic joint disease,1038,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.","Is the triple ""Aspirin disrupts arthritic joint disease"" supported by the sentence: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?",False, +18445880,Aspirin disrupts ovarian cancer,1039,"Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.","Is the triple ""Aspirin disrupts ovarian cancer"" supported by the sentence: ""Moreover, this thesis provides further evidence that use of low-dose aspirin is associated with a reduced risk of epithelial ovarian cancer.""?",False, +18225861,Aspirin disrupts Hemorrhage,1040,"Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.","Is the triple ""Aspirin disrupts Hemorrhage"" supported by the sentence: ""Six studies tested OAC and clopidogrel (1,263 patients) versus OAC, aspirin, and clopidogrel (3,055 patients) with a significant reduction of bleeding (OR 0.79, 95% CI 0.64 to 0.98), without affecting rates of death, MI, stroke, and stent thrombosis (OR 0.90, 95% CI 0.69 to 1.23) also when including clinical data from randomized controlled trials or multivariate analysis.""?",False, +18203584,Aspirin disrupts brain aneurysm,1041,Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.,"Is the triple ""Aspirin disrupts brain aneurysm"" supported by the sentence: ""Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects.""?",False, +17476286,Aspirin disrupts Fatigue,1042,"In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.","Is the triple ""Aspirin disrupts Fatigue"" supported by the sentence: ""In contrast, our findings may help explain how RCTs of cooling garments and antipyretics (aspirin) have effectively reduced MS fatigue, and encourage further research on cooling/antipyretic treatments of fatigue in RRMS.""?",False, +17225706,Aspirin disrupts transient ischemic attack,1043,The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.,"Is the triple ""Aspirin disrupts transient ischemic attack"" supported by the sentence: ""The combination of aspirin and dipyridamole is slightly better than aspirin alone and in particular reduced nonfatal stroke/TIA - hence it is recommended as an alternative and may be used in patients with recurrent events while on regular aspirin.""?",False, +16676314,Aspirin disrupts ulcer disease,1044,"Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.","Is the triple ""Aspirin disrupts ulcer disease"" supported by the sentence: ""Hence, diets rich in nitrate and reductive polyphenols have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk.""?",False, +16484307,Aspirin disrupts acute lung injury,1045,"METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.","Is the triple ""Aspirin disrupts acute lung injury"" supported by the sentence: ""METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk.""?",False, +14296080,Aspirin disrupts Pregnancy,1046,"Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.","Is the triple ""Aspirin disrupts Pregnancy"" supported by the sentence: ""Four women were treated with aspirin 800 mg three times daily; in 3 women aspirin was gradually stopped at 20 weeks gestation, while in one case aspirin was continued till delivery.""?",False, +14068900,Aspirin disrupts active peptic ulcer disease,1047,"In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.","Is the triple ""Aspirin disrupts active peptic ulcer disease"" supported by the sentence: ""In addition, epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding.""?",False, +13892678,Aspirin disrupts breast neoplasm,1048,Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.,"Is the triple ""Aspirin disrupts breast neoplasm"" supported by the sentence: ""Dietary acetylsalicylic acid (ASA) has been recently reported to inhibit DMBA-mediated mammary tumour formation in rats.""?",False, +13449558,Aspirin disrupts colorectal neoplasm,1049,"BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.","Is the triple ""Aspirin disrupts colorectal neoplasm"" supported by the sentence: ""BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent.""?",False, +12947740,Aspirin disrupts diabetic retinopathy,1050,"It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.","Is the triple ""Aspirin disrupts diabetic retinopathy"" supported by the sentence: ""It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy.""?",False, +12815470,Aspirin disrupts atherosclerosis,1051,"CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.","Is the triple ""Aspirin disrupts atherosclerosis"" supported by the sentence: ""CONCLUSION: The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.""?",False, +12714476,Aspirin disrupts cataract,1052,Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.,"Is the triple ""Aspirin disrupts cataract"" supported by the sentence: ""Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.""?",False, +12478523,Aspirin disrupts preeclampsia,1053,Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?,"Is the triple ""Aspirin disrupts preeclampsia"" supported by the sentence: ""Meta-analysis of aspirin for the prevention of preeclampsia: do the main randomized controlled trials support an association between low-dose aspirin and a reduced risk of developing preeclampsia?""?",False, +12450426,Aspirin disrupts Barrett esophagus,1054,"Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].","Is the triple ""Aspirin disrupts Barrett esophagus"" supported by the sentence: ""Use of aspirin and NSAIDs was associated with a reduced risk of Barrett's esophagus [odds ratio [OR; 95% confidence interval (95% CI)], 0.53 (0.31-0.90) and 0.40 (0.19-0.81), respectively] and esophageal adenocarcinoma [OR (95% CI), 0.57 (0.36-0.93) and 0.58 (0.31-1.08), respectively].""?",False, +12023670,Aspirin disrupts hypertensive disorder,1055,The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.,"Is the triple ""Aspirin disrupts hypertensive disorder"" supported by the sentence: ""The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.""?",False, +11827133,Aspirin disrupts diabetes mellitus,1056,"Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.","Is the triple ""Aspirin disrupts diabetes mellitus"" supported by the sentence: ""Those with diabetes and controls were sensitive to aspirin inhibition of platelet aggregation induced by 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 microg/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.""?",False, +10318928,Aspirin disrupts Myalgia,1057,"RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).","Is the triple ""Aspirin disrupts Myalgia"" supported by the sentence: ""RESULTS: ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01).""?",False, +9742254,Aspirin disrupts adenoma,1058,"BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.","Is the triple ""Aspirin disrupts adenoma"" supported by the sentence: ""BACKGROUND: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer.""?",False, +9148614,Aspirin disrupts neoplasm,1059,"Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.","Is the triple ""Aspirin disrupts neoplasm"" supported by the sentence: ""Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.""?",False, +8526818,Aspirin disrupts myocardial infarction,1060,"Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).","Is the triple ""Aspirin disrupts myocardial infarction"" supported by the sentence: ""Then, in three hypothetical clinical situations in which the chance of stroke or MI was varied, PTOT was used to directly determine treatment thresholds for aspirin therapy (i.e., the smallest reduction in MI or stroke risk for which participants would be willing to take aspirin).""?",False, +7995298,Aspirin disrupts Inflammation,1061,RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.,"Is the triple ""Aspirin disrupts Inflammation"" supported by the sentence: ""RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation.""?",False, +7878103,Aspirin disrupts prostate cancer,1062,"Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).","Is the triple ""Aspirin disrupts prostate cancer"" supported by the sentence: ""Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01).""?",False, +7775480,Aspirin disrupts Pain,1063,"The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.","Is the triple ""Aspirin disrupts Pain"" supported by the sentence: ""The Dictum: ""A tablet of aspirin to kill pain is always beneficial to any electrotherapy or thermo therapy,"" should always be kept in mind while prescribing a therapeutic modality to the patient or ordering an equipment for the PMR department.""?",False, +7723340,Aspirin disrupts stroke disorder,1064,"Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.","Is the triple ""Aspirin disrupts stroke disorder"" supported by the sentence: ""Aspirin (six trials, 3119 participants) reduced stroke by 22% (CI, 2% to 38%); absolute risk reductions were 1.5% per year for primary prevention and 2.5% per year for secondary prevention.""?",False, +7712646,Aspirin disrupts coronary artery disorder,1065,Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.,"Is the triple ""Aspirin disrupts coronary artery disorder"" supported by the sentence: ""Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.""?",False, +7261879,Aspirin disrupts thrombotic disease,1066,"In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.","Is the triple ""Aspirin disrupts thrombotic disease"" supported by the sentence: ""In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition.""?",False, +24597938,Aspirin prevents thrombophilia,1067,Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.,"Is the triple ""Aspirin prevents thrombophilia"" supported by the sentence: ""Aspirin prevented the generation of hypercoagulability and may be of importance in delaying the development of penile atherosclerosis and ageing impotence.""?",False, +24091248,Aspirin prevents disseminated intravascular coagulation,1068,Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.,"Is the triple ""Aspirin prevents disseminated intravascular coagulation"" supported by the sentence: ""Our investigations on platelet and coagulation indicate that aspirin prevents disseminated intravascular coagulation through an interference with the blood coagulation and Hageman factor activation rather than by the inhibition of platelet aggregation and availability of platelet procoagulant activity.""?",False, +24015329,Aspirin prevents neoplasm of esophagus,1069,"Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.","Is the triple ""Aspirin prevents neoplasm of esophagus"" supported by the sentence: ""Aspirin was shown to reduce the colorectal cancer under the age of 50, and on a large scale of cohort study with long-term tracking reported that aspirin was shown to reduce colorectal cancer, gastric cancer, and esophageal cancer as well.""?",False, +23042755,Aspirin prevents brain aneurysm,1070,BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.,"Is the triple ""Aspirin prevents brain aneurysm"" supported by the sentence: ""BACKGROUND: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture.""?",False, +22291835,Aspirin prevents Hemorrhage,1071,"CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.","Is the triple ""Aspirin prevents Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Among patients undergoing PCI, short-term DAPT with continuation of either aspirin or P2Y12i reduced bleeding without increasing ischemic outcomes when compared with long-term DAPT.""?",False, +21962376,Aspirin prevents venous thromboembolism,1072,Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.,"Is the triple ""Aspirin prevents venous thromboembolism"" supported by the sentence: ""Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement.""?",False, +21587985,Aspirin prevents blood coagulation disease,1073,Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.,"Is the triple ""Aspirin prevents blood coagulation disease"" supported by the sentence: ""Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage.""?",False, +21116357,Aspirin prevents schizophrenia,1074,The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.,"Is the triple ""Aspirin prevents schizophrenia"" supported by the sentence: ""The mixed COX inhibitor aspirin (acetylsalicylic acid) seems to have both protective and therapeutic effects on schizophrenia.""?",False, +20356983,Aspirin prevents acute lung injury,1075,"Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).","Is the triple ""Aspirin prevents acute lung injury"" supported by the sentence: ""Aspirin could reduce the rate of ARDS/ALI (OR 0.71, 95% confidence interval (CI) 0.58-0.86) but not the mortality (OR 0.87, 95% CI 0.71-1.07).""?",False, +20189716,Aspirin prevents brain infarction,1076,"We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.","Is the triple ""Aspirin prevents brain infarction"" supported by the sentence: ""We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties.""?",False, +18414184,Aspirin prevents multiple sclerosis,1077,"Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.","Is the triple ""Aspirin prevents multiple sclerosis"" supported by the sentence: ""Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis.""?",False, +18344373,Aspirin prevents bone fracture,1078,"If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.","Is the triple ""Aspirin prevents bone fracture"" supported by the sentence: ""If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.""?",False, +17911903,Aspirin prevents adult acute respiratory distress syndrome,1079,"Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.","Is the triple ""Aspirin prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing.""?",False, +17240995,Aspirin prevents hepatocellular carcinoma,1080,Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).,"Is the triple ""Aspirin prevents hepatocellular carcinoma"" supported by the sentence: ""Recent analyses of large cohorts suggest that statins or aspirin may reduce the risk of hepatocellular carcinoma (HCC).""?",False, +16163718,Aspirin prevents Sepsis,1081,The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.,"Is the triple ""Aspirin prevents Sepsis"" supported by the sentence: ""The article reviews the current literature regarding the use of aspirin and statins for the prevention of sepsis.""?",False, +15608454,Aspirin prevents squamous cell carcinoma,1082,"CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.","Is the triple ""Aspirin prevents squamous cell carcinoma"" supported by the sentence: ""CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.""?",False, +14796348,Aspirin prevents arthritic joint disease,1083,"Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.","Is the triple ""Aspirin prevents arthritic joint disease"" supported by the sentence: ""Aspirin, nonacetylated salicylates, and numerous other nonsteroidal antiinflammatory drugs (NSAIDs) are used in rheumatoid arthritis (RA) patients to decrease joint inflammation and improve function.""?",False, +14183452,Aspirin prevents pneumonia,1084,Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.,"Is the triple ""Aspirin prevents pneumonia"" supported by the sentence: ""Aspirin and indomethacin reduce lung inflammation of mice exposed to cigarette smoke.""?",False, +13992680,Aspirin prevents diabetes mellitus,1085,We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.,"Is the triple ""Aspirin prevents diabetes mellitus"" supported by the sentence: ""We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.""?",False, +13992679,Aspirin prevents type 2 diabetes mellitus,1086,CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.,"Is the triple ""Aspirin prevents type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data suggest that long-term low-dose aspirin does not prevent the development of clinical type 2 diabetes in initially healthy women.""?",False, +13770407,Aspirin prevents diabetic retinopathy,1087,"According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.","Is the triple ""Aspirin prevents diabetic retinopathy"" supported by the sentence: ""According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.""?",False, +13624060,Aspirin prevents injury,1088,The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.,"Is the triple ""Aspirin prevents injury"" supported by the sentence: ""The present study was designed to determine whether low-dose aspirin might prevent cerebrovascular injury in salt-loaded SHRSP by protecting oxidative damage.""?",False, +13536062,Aspirin prevents non-small cell lung carcinoma,1089,CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.,"Is the triple ""Aspirin prevents non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Our results suggest that long-term use of adult-strength aspirin may reduce the risk of NSCLC in women.""?",False, +13041448,Aspirin prevents atrial fibrillation,1090,"Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.","Is the triple ""Aspirin prevents atrial fibrillation"" supported by the sentence: ""Antiplatelet agents such as clopidogrel have proven efficacy and superiority compared to aspirin to prevent systemic vascular events in at-risk patient populations, but currently they do not play an important role in the prevention of AF related thromboembolic events.""?",False, +12791249,Aspirin prevents asthma,1091,"CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.","Is the triple ""Aspirin prevents asthma"" supported by the sentence: ""CONCLUSIONS: Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men.""?",False, +12594676,Aspirin prevents Fatigue,1092,Aspirin reduces MS fatigue in some patients.,"Is the triple ""Aspirin prevents Fatigue"" supported by the sentence: ""Aspirin reduces MS fatigue in some patients.""?",False, +12361944,Aspirin prevents active peptic ulcer disease,1093,CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.,"Is the triple ""Aspirin prevents active peptic ulcer disease"" supported by the sentence: ""CONCLUSIONS: The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding.""?",False, +12273189,Aspirin prevents Myalgia,1094,BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.,"Is the triple ""Aspirin prevents Myalgia"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: Data from several studies implicate that pre-treatment with non-selective cyclooxygenase inhibitors such as aspirin or diclofenac may decrease the incidence of postoperative succinycholine-related myalgia.""?",False, +11593026,Aspirin prevents colorectal neoplasm,1095,Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.,"Is the triple ""Aspirin prevents colorectal neoplasm"" supported by the sentence: ""Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease.""?",False, +11289178,Aspirin prevents migraine disorder,1096,"The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.","Is the triple ""Aspirin prevents migraine disorder"" supported by the sentence: ""The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan.""?",False, +11042545,Aspirin prevents Barrett esophagus,1097,"BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.","Is the triple ""Aspirin prevents Barrett esophagus"" supported by the sentence: ""BACKGROUND: Recent data suggest that nonsteroidal anti-inflammatory drugs, including aspirin, may prevent the progression of Barrett's esophagus to adenocarcinoma.""?",False, +10366572,Aspirin prevents cerebrovascular disorder,1098,"Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.","Is the triple ""Aspirin prevents cerebrovascular disorder"" supported by the sentence: ""Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins.""?",False, +10293726,Aspirin prevents prostate cancer,1099,"The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.","Is the triple ""Aspirin prevents prostate cancer"" supported by the sentence: ""The results suggest that long-term and regular use of aspirin, at a dosage beneath that usually recommended for an anti-inflammatory effect, may prevent prostate cancer.""?",False, +10185706,Aspirin prevents colonic neoplasm,1100,Can resistant starch and/or aspirin prevent the development of colonic neoplasia?,"Is the triple ""Aspirin prevents colonic neoplasm"" supported by the sentence: ""Can resistant starch and/or aspirin prevent the development of colonic neoplasia?""?",False, +10099399,Aspirin prevents atherosclerosis,1101,Aspirin treatment reduced the development of atherosclerosis by approximately 47%.,"Is the triple ""Aspirin prevents atherosclerosis"" supported by the sentence: ""Aspirin treatment reduced the development of atherosclerosis by approximately 47%.""?",False, +10096705,Aspirin prevents cerebral infarction,1102,"Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.","Is the triple ""Aspirin prevents cerebral infarction"" supported by the sentence: ""Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.""?",False, +10004143,Aspirin prevents blindness (disorder),1103,"Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.","Is the triple ""Aspirin prevents blindness (disorder)"" supported by the sentence: ""Over the 10 to 15 years after clinical diagnosis, tight glycemic control probably reduces the risk for blindness and end-stage renal disease, and aggressive control of hypertension, lipid therapy, and aspirin use reduce cardiovascular events.""?",False, +9665356,Aspirin prevents hypertensive disorder,1104,CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.,"Is the triple ""Aspirin prevents hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats.""?",False, +9388878,Aspirin prevents coronary artery disorder,1105,[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].,"Is the triple ""Aspirin prevents coronary artery disorder"" supported by the sentence: ""[Meta-analysis of the scientific evidence on the usefulness of sporadic intake of acetylsalicylic acid in the prevention of coronary heart disease].""?",False, +9150304,Aspirin prevents habitual spontaneous abortion,1106,"Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.","Is the triple ""Aspirin prevents habitual spontaneous abortion"" supported by the sentence: ""Low-dose aspirin can reduce the risk of recurrent pre-eclampsia by about 15%, but the role of UH and LMWH in the prevention of recurrent miscarriage or obstetric complications associated with uteroplacental insufficiency is still uncertain.""?",False, +8853513,Aspirin prevents gastric ulcer,1107,"All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.","Is the triple ""Aspirin prevents gastric ulcer"" supported by the sentence: ""All the drugs in the dose of 50 mg/kg, p.o., 60 min prior to experiment, showed significant protection against gastric ulcers induced by 2 hr cold restraint stress, aspirin (200 mg/kg, 4 hr) and 4 hr pylorus ligation.""?",False, +8755758,Aspirin prevents vascular disorder,1108,"Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.","Is the triple ""Aspirin prevents vascular disorder"" supported by the sentence: ""Statins are commonly used to lower the blood cholesterol concentration, and aspirin is widely used to prevent occlusive vascular disease.""?",False, +8494726,Aspirin prevents ulcer disease,1109,"Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.","Is the triple ""Aspirin prevents ulcer disease"" supported by the sentence: ""Non-steroidal, anti-inflammatory drugs such as acetylsalicylic acid, indomethacin, naproxen and ibuprofen were linked covalently to glycerides to reduce their ulcerogenicity.""?",False, +8347839,Aspirin prevents peptic ulcer disease,1110,"METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.","Is the triple ""Aspirin prevents peptic ulcer disease"" supported by the sentence: ""METHODS: Three effects were investigated in rats: (i) the protective effect of HGL on peptic ulceration produced by using pyloric ligation in combination with South Indian diet or rice bran oil, or by cysteamine, alcohol or aspirin; (ii) the effect of HGL on mast cell degranulation in response to pyloric ligation and rice bran oil; and (iii) the healing effect of HGL on acute gastric ulceration produced by alcohol, on chronic gastric ulceration produced by topical acetic acid or on chronic duodenal ulcer following cysteamine.""?",False, +8325441,Aspirin prevents ischemic disease,1111,Peri-operative aspirin can prevent post-operative ischemia and thrombosis.,"Is the triple ""Aspirin prevents ischemic disease"" supported by the sentence: ""Peri-operative aspirin can prevent post-operative ischemia and thrombosis.""?",False, +7877588,Aspirin prevents cardiovascular disorder,1112,"METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.","Is the triple ""Aspirin prevents cardiovascular disorder"" supported by the sentence: ""METHODS: The Women's Health Study is a randomized, double-blind, placebo-controlled trial originally testing aspirin, vitamin E, and beta-carotene in the prevention of cancer and cardiovascular disease among 39 876 women aged 45 years or older.""?",False, +7852267,Aspirin prevents Headache,1113,"Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.","Is the triple ""Aspirin prevents Headache"" supported by the sentence: ""Acetazolamide, dexamethasone, and aspirin were also found to prevent HAH.""?",False, +7716613,Aspirin prevents neoplasm,1114,"Furthermore, aspirin decreased the total tumors (P < 0.05).","Is the triple ""Aspirin prevents neoplasm"" supported by the sentence: ""Furthermore, aspirin decreased the total tumors (P < 0.05).""?",False, +7603499,Aspirin prevents myocardial ischemia,1115,Low dose warfarin and aspirin in preventing IHD.,"Is the triple ""Aspirin prevents myocardial ischemia"" supported by the sentence: ""Low dose warfarin and aspirin in preventing IHD.""?",False, +7487700,Aspirin prevents Inflammation,1116,"Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.","Is the triple ""Aspirin prevents Inflammation"" supported by the sentence: ""Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.""?",False, +7457050,Aspirin prevents peripheral vascular disease,1117,"Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.","Is the triple ""Aspirin prevents peripheral vascular disease"" supported by the sentence: ""Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively.""?",False, +7455467,Aspirin prevents Ischemic stroke,1118,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents Ischemic stroke"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, +7455466,Aspirin prevents stroke disorder,1119,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents stroke disorder"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, +7455465,Aspirin prevents transient ischemic attack,1120,Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.,"Is the triple ""Aspirin prevents transient ischemic attack"" supported by the sentence: ""Aspirin modestly reduces the risk for subsequent ischemic stroke after a transient ischemic attack or initial stroke.""?",False, +7419265,Aspirin prevents heart disorder,1121,"RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.","Is the triple ""Aspirin prevents heart disorder"" supported by the sentence: ""RESULTS: Overall, 38% of respondents reported using aspirin at least three times a week to prevent heart disease.""?",False, +7368248,Aspirin prevents thrombotic disease,1122,Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.,"Is the triple ""Aspirin prevents thrombotic disease"" supported by the sentence: ""Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.""?",False, +7317027,Aspirin prevents preeclampsia,1123,Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.,"Is the triple ""Aspirin prevents preeclampsia"" supported by the sentence: ""Low-dose acetylsalicylic acid reduces the risk of preeclampsia in pregnant women at high risk for preeclampsia.""?",False, +7275741,Aspirin prevents acute coronary syndrome,1124,"CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.","Is the triple ""Aspirin prevents acute coronary syndrome"" supported by the sentence: ""CONCLUSIONS: Long-acting nitrates as well as aspirin are suggested to have a protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.""?",False, +7264064,Aspirin prevents Pain,1125,Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.,"Is the triple ""Aspirin prevents Pain"" supported by the sentence: ""Double-blind clinical trials have demonstrated that celecoxib is as effective in ameliorating the signs and symptoms of osteoarthritis and rheumatoid arthritis as naproxen and as effective as aspirin in reducing pain following dental extraction.""?",False, +7196018,Aspirin prevents myocardial infarction,1126,"BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.","Is the triple ""Aspirin prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death.""?",False, +7159192,Aspirin prevents fetal growth restriction,1127,"If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.","Is the triple ""Aspirin prevents fetal growth restriction"" supported by the sentence: ""If the combination of IV Ig, aspirin, and heparin significantly decreases the incidences of FGR and prematurity, it may be a cost-effective primary therapy for pregnancies complicated by the antiphospholipid syndrome.""?",False, +7110859,Aspirin prevents thrombophilia due to thrombin defect,1128,[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].,"Is the triple ""Aspirin prevents thrombophilia due to thrombin defect"" supported by the sentence: ""[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].""?",False, +22126985,Aspirin exacerbates gastric ulcer,1129,"Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.","Is the triple ""Aspirin exacerbates gastric ulcer"" supported by the sentence: ""Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats.""?",False, +21411566,Aspirin exacerbates macular degeneration,1130,Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?,"Is the triple ""Aspirin exacerbates macular degeneration"" supported by the sentence: ""Does Aspirin Worsen Macular Degeneration in a Clinically Meaningful Way?""?",False, +21359197,Aspirin exacerbates acute coronary syndrome,1131,Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.,"Is the triple ""Aspirin exacerbates acute coronary syndrome"" supported by the sentence: ""Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report.""?",False, +26115547,Aspirin predisposes cerebral infarction,1132,"Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.","Is the triple ""Aspirin predisposes cerebral infarction"" supported by the sentence: ""Amongst the 4 substances studied in 9 trials, dipyridamole, clofibrate, sulfinpyrazone and aspirin, only aspirin at the dose of 1 g brought about a statistically significant reduction in the risk of cerebral infarction and death in patients who had suffered an initial transient or rapidly regressive cerebral ischaemic accident.""?",False, +25254777,Aspirin predisposes essential thrombocythemia,1133,"Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.","Is the triple ""Aspirin predisposes essential thrombocythemia"" supported by the sentence: ""Low dose (81-100 mg) aspirin once daily (od), which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only.""?",False, +23315977,Aspirin predisposes brain aneurysm,1134,The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.,"Is the triple ""Aspirin predisposes brain aneurysm"" supported by the sentence: ""The trial registry name:: The Clinic Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia Clinical Trial Registration-URL:: http://www.clinicaltrials.gov Unique identifier:: NCT02846259.""?",False, +21525767,Aspirin predisposes Fever,1135,Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).,"Is the triple ""Aspirin predisposes Fever"" supported by the sentence: ""Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD).""?",False, +21487721,Aspirin predisposes Hemorrhage,1136,"The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).","Is the triple ""Aspirin predisposes Hemorrhage"" supported by the sentence: ""The risk of bleeding was also lower for clopidogrel versus aspirin (0.57 [0.45, 0.74]).""?",False, +20679052,Aspirin predisposes blood coagulation disease,1137,"Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.","Is the triple ""Aspirin predisposes blood coagulation disease"" supported by the sentence: ""Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge.""?",False, +20234206,Aspirin predisposes hepatocellular carcinoma,1138,The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.,"Is the triple ""Aspirin predisposes hepatocellular carcinoma"" supported by the sentence: ""The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear.""?",False, +20155873,Aspirin predisposes placental insufficiency,1139,"There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.","Is the triple ""Aspirin predisposes placental insufficiency"" supported by the sentence: ""There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency.""?",False, +19346376,Aspirin predisposes chronic renal failure syndrome,1140,The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.,"Is the triple ""Aspirin predisposes chronic renal failure syndrome"" supported by the sentence: ""The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment.""?",False, +18235965,Aspirin predisposes macular degeneration,1141,[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].,"Is the triple ""Aspirin predisposes macular degeneration"" supported by the sentence: ""[Does acetylsalicylic acid and vitamin K antagonists are risk factors of macular degeneration related with age?].""?",False, +17872103,Aspirin predisposes atrial fibrillation,1142,"The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.","Is the triple ""Aspirin predisposes atrial fibrillation"" supported by the sentence: ""The aim of this review is to update the available data concerning chronic use of NSAIDs in patients with and without CV disease by analyzing the mechanisms of action, the interference of specific NSAIDs with the established CV protective role of low-dose aspirin, and the potential increased risk of myocardial infarction, stroke, hypertension, heart failure and atrial fibrillation.""?",False, +17123250,Aspirin predisposes acute coronary syndrome,1143,"In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.","Is the triple ""Aspirin predisposes acute coronary syndrome"" supported by the sentence: ""In a multivariate analysis, lower levels of high-density lipoprotein cholesterol and the ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) (EPA/AA), and less aspirin, oral hypoglycemic agent, and calcium channel blocker (CCB) use were independent risk factors for ACS in all patients.""?",False, +16813141,Aspirin predisposes melanoma,1144,"In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.","Is the triple ""Aspirin predisposes melanoma"" supported by the sentence: ""In contrast, use of non-ASA NSAIDs and acetaminophen were not associated with melanoma risk.""?",False, +16162173,Aspirin predisposes ulcerative colitis,1145,"Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.","Is the triple ""Aspirin predisposes ulcerative colitis"" supported by the sentence: ""Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study.""?",False, +15461534,Aspirin predisposes gastric ulcer,1146,Aspirin specifically predisposes to gastric ulcer.,"Is the triple ""Aspirin predisposes gastric ulcer"" supported by the sentence: ""Aspirin specifically predisposes to gastric ulcer.""?",False, +14856258,Aspirin predisposes neoplasm of esophagus,1147,"BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.","Is the triple ""Aspirin predisposes neoplasm of esophagus"" supported by the sentence: ""BACKGROUND & AIMS: Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia.""?",False, +14426809,Aspirin predisposes neoplasm,1148,NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.,"Is the triple ""Aspirin predisposes neoplasm"" supported by the sentence: ""NSAIDs/aspirin appear to reduce cancer risk whereas statin use is not significantly associated with the risk of neoplasia in patients with BE.""?",False, +14234947,Aspirin predisposes diabetes mellitus,1149,"This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.","Is the triple ""Aspirin predisposes diabetes mellitus"" supported by the sentence: ""This trend was continued during 22 years of follow-up, indicating that self-selection of any use of aspirin is associated with a significant, approximately 14% decrease in the risk of diabetes.""?",False, +14126301,Aspirin predisposes cerebrovascular disorder,1150,"We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).","Is the triple ""Aspirin predisposes cerebrovascular disorder"" supported by the sentence: ""We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).""?",False, +14052964,Aspirin predisposes Inflammation,1151,"Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).","Is the triple ""Aspirin predisposes Inflammation"" supported by the sentence: ""Multivariable regression analyses, stratified by gender, were performed to assess whether AA ethnicity was associated with D-dimer levels after adjustment for age, body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, diabetes, history of smoking, medication (statin and aspirin) use, lifestyle variables (physical activity, alcohol intake, and education), estimated glomerular filtration rate (eGFR), and a marker of inflammation, C-reactive protein (CRP).""?",False, +14015029,Aspirin predisposes transient ischemic attack,1152,"When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.","Is the triple ""Aspirin predisposes transient ischemic attack"" supported by the sentence: ""When only stroke was considered as the end point, dipyridamole and acetylsalicylic acid seemed to be more effective in reducing the risk of transient ischemic attacks than stroke, and more effective in men than in women.""?",False, +13644771,Aspirin predisposes asthma,1153,A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.,"Is the triple ""Aspirin predisposes asthma"" supported by the sentence: ""A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.""?",False, +13536064,Aspirin predisposes non-small cell lung carcinoma,1154,Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.,"Is the triple ""Aspirin predisposes non-small cell lung carcinoma"" supported by the sentence: ""Baby aspirin and NSAID use was associated with a significant reduction in risk of NSCLC only among 65- to 74-year-olds.""?",False, +13299957,Aspirin predisposes ovarian cancer,1155,Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.,"Is the triple ""Aspirin predisposes ovarian cancer"" supported by the sentence: ""Regular use of aspirin and other nonsteroidal anti-inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only.""?",False, +12673405,Aspirin predisposes bone fracture,1156,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Aspirin predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, +12382415,Aspirin predisposes colorectal neoplasm,1157,"AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Aspirin predisposes colorectal neoplasm"" supported by the sentence: ""AIM: To study whether BE is associated with an increased risk of colorectal neoplasia, and if it is, whether it is dependent on use of proton-pump inhibitors (PPIs) or aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).""?",False, +11071059,Aspirin predisposes injury,1158,"Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.","Is the triple ""Aspirin predisposes injury"" supported by the sentence: ""Aspirin is an independent risk factor for UGI tract injury, even at the low doses used for cardiovascular prophylaxis.""?",False, +10962122,Aspirin predisposes ischemic disease,1159,"The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.","Is the triple ""Aspirin predisposes ischemic disease"" supported by the sentence: ""The risk of severe ischemia, recurrent angina or heart failure was also significantly reduced in patients receiving clopidogrel plus aspirin.""?",False, +10547299,Aspirin predisposes coronary artery disorder,1160,"Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.","Is the triple ""Aspirin predisposes coronary artery disorder"" supported by the sentence: ""Apart from reduction of the known risk factors of coronary heart disease, aspirin may be given to all patients at risk.""?",False, +10337650,Aspirin predisposes adenoma,1161,CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.,"Is the triple ""Aspirin predisposes adenoma"" supported by the sentence: ""CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment.""?",False, +9857077,Aspirin predisposes vascular disorder,1162,"Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.","Is the triple ""Aspirin predisposes vascular disorder"" supported by the sentence: ""Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.""?",False, +9535755,Aspirin predisposes thrombotic disease,1163,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes thrombotic disease"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, +9535754,Aspirin predisposes hypertensive disorder,1164,"Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.","Is the triple ""Aspirin predisposes hypertensive disorder"" supported by the sentence: ""Although several clinical questions remain (eg, use with low-dose aspirin, risk of thrombosis, myocardial infarction, edema, and hypertension), the emergence and clinical utility of coxibs is likely to continue on the basis of their efficacy and relative GI safety advantage.""?",False, +9491661,Aspirin predisposes cardiovascular disorder,1165,"In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).","Is the triple ""Aspirin predisposes cardiovascular disorder"" supported by the sentence: ""In patients with one or more risk factors for cardiovascular disease but no cardiovascular disease, aspirin was used in 27/223 (12%) versus 195/223 (88%) (p 0.0001).""?",False, +9477464,Aspirin predisposes prostate cancer,1166,"Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).","Is the triple ""Aspirin predisposes prostate cancer"" supported by the sentence: ""Other intriguing positive findings from past prospective studies of supplements suggest that aspirin and other nonsteroidal anti-inflammatory drugs have a role in reducing the risk of prostate cancer or other types of cancer (eg, colon cancer).""?",False, +9404829,Aspirin predisposes ulcer disease,1167,"Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.","Is the triple ""Aspirin predisposes ulcer disease"" supported by the sentence: ""Age is mainly a marker for the increased prevalence of other complicated ulcer risk factors such as previous ulcer history and use of anti-coagulants, steroids and aspirin.""?",False, +8850172,Aspirin predisposes myocardial ischemia,1168,"Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.","Is the triple ""Aspirin predisposes myocardial ischemia"" supported by the sentence: ""Details were taken regarding the characteristics of the pain, use of referral letter, presence of risk factors for ischaemic heart disease and pre-hospital administration of drugs, including aspirin.""?",False, +8763743,Aspirin predisposes thrombophilia due to thrombin defect,1169,The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.,"Is the triple ""Aspirin predisposes thrombophilia due to thrombin defect"" supported by the sentence: ""The reported efficacy of aspirin for prevention of venous thrombosis is consistent with the prediction that certain platelet defects may increase the risk of venous thrombosis.""?",False, +8545255,Aspirin predisposes Ischemic stroke,1170,"When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.","Is the triple ""Aspirin predisposes Ischemic stroke"" supported by the sentence: ""When strokes were subdivided by type, there was no significant effect of aspirin therapy on the risk of ischemic stroke, but, while based on small numbers, there was a 1.7-fold apparent increase (95% CI, 6%-269%) in the risk of hemorrhagic stroke, which did achieve statistical significance.""?",False, +7865543,Aspirin predisposes Headache,1171,We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.,"Is the triple ""Aspirin predisposes Headache"" supported by the sentence: ""We have now used data from a recent trial comparing the bioequivalence of two formulations of the fixed combination of 200 mg dipyridamole in an extended release formulation and 25 mg ASA to explore predicting factors for headaches associated with this drug combination.""?",False, +7858710,Aspirin predisposes myocardial infarction,1172,"In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.","Is the triple ""Aspirin predisposes myocardial infarction"" supported by the sentence: ""In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect.""?",False, +7667039,Aspirin predisposes preeclampsia,1173,"However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.","Is the triple ""Aspirin predisposes preeclampsia"" supported by the sentence: ""However, the confidence intervals for the effect were wide, comparable with aspirin having no effect or leading to a 16-fold reduction in the risk of preeclampsia.""?",False, +7659453,Aspirin predisposes stroke disorder,1174,RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.,"Is the triple ""Aspirin predisposes stroke disorder"" supported by the sentence: ""RESULTS: There was no clear relationship between aspirin use and risk of total stroke; risk was slightly reduced among women who took 1 to 6 aspirin per week and slightly increased among women who took 7 or more aspirin per week.""?",False, +7653535,Aspirin predisposes peptic ulcer disease,1175,"BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.","Is the triple ""Aspirin predisposes peptic ulcer disease"" supported by the sentence: ""BACKGROUND: Low-dose aspirin (acetylsalicylic acid, ASA) increases the risk of developing peptic ulceration.""?",False, +7596288,Aspirin predisposes atherosclerosis,1176,"OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.","Is the triple ""Aspirin predisposes atherosclerosis"" supported by the sentence: ""OBJECTIVES: To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.""?",False, +7078619,Aspirin predisposes active peptic ulcer disease,1177,Risk of major gastrointestinal bleeding with aspirin.,"Is the triple ""Aspirin predisposes active peptic ulcer disease"" supported by the sentence: ""Risk of major gastrointestinal bleeding with aspirin.""?",False, +23297288,Vemurafenib prevents neoplasm,1178,Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.,"Is the triple ""Vemurafenib prevents neoplasm"" supported by the sentence: ""Rapid tumor regrowth 4 months after surgery led to treatment with vemurafenib that resulted in tumor reduction within 6 weeks.""?",False, +22851133,Dabrafenib related to melanoma,1179,"KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.","Is the triple ""Dabrafenib related to melanoma"" supported by the sentence: ""KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF -mutant melanoma.""?",False, +18622575,Sodium heparin related to PROTAMINE SULFATE,1180,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, +18622575,Sodium heparin related to PROTAMINE SULFATE,1181,STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.,"Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""STUDY SELECTION: We included clinical trials and observational studies comparing reversal of heparin with protamine sulfate vs no reversal in patients undergoing carotid revascularization and reporting stroke during hospitalization.""?",False, +26359747,Sodium heparin related to PROTAMINE SULFATE,1182,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, +26359747,Sodium heparin related to PROTAMINE SULFATE,1183,"For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.","Is the triple ""Sodium heparin related to PROTAMINE SULFATE"" supported by the sentence: ""For a given heparin, plotting inverse clotting times measured without NS, and in the presence of PF4 or PS, vs heparin concentration yielded approximately parallel straight lines displaced horizontally according to the amount of NS.""?",False, +24697302,Sodium heparin has part PROTAMINE SULFATE,1184,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, +24697302,Sodium heparin has part PROTAMINE SULFATE,1185,Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.,"Is the triple ""Sodium heparin has part PROTAMINE SULFATE"" supported by the sentence: ""Premixing protamine sulfate with heparin prior to intracarotid administration greatly reduced or abolished Evans blue staining of the brain as did delayed administration of the marker dye.""?",False, +10513644,Sodium heparin coexists with PROTAMINE SULFATE,1186,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, +10513644,Sodium heparin coexists with PROTAMINE SULFATE,1187,Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.,"Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""Crossed immunoelectrophoresis of antithrombin III (AT III) and affinity chromatography of LHG- and Heparin-cellulose showed that AT III was substantially less dissociated from its binding to LHG than to Heparin in the presence of PS.""?",False, +15306394,Sodium heparin coexists with PROTAMINE SULFATE,1188,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, +15306394,Sodium heparin coexists with PROTAMINE SULFATE,1189,"An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.","Is the triple ""Sodium heparin coexists with PROTAMINE SULFATE"" supported by the sentence: ""An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator.""?",False, +10518221,Sodium heparin physically interacts with PROTAMINE SULFATE,1190,[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""[Comparative study of the inhibitory action of protamine sulfate on clearance by heparin and gastric mucin preparation].""?",False, +9906740,Sodium heparin physically interacts with PROTAMINE SULFATE,1191,Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.,"Is the triple ""Sodium heparin physically interacts with PROTAMINE SULFATE"" supported by the sentence: ""Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT.""?",False, +8278260,Sodium heparin affects PROTAMINE SULFATE,1192,Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.,"Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""Lipolysis is strongly inhibited by NaCl (0.5 M) and protamine sulfate (1 mg/ml) and partially inhibited by heparin.""?",False, +9085295,Sodium heparin affects PROTAMINE SULFATE,1193,"One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.","Is the triple ""Sodium heparin affects PROTAMINE SULFATE"" supported by the sentence: ""One to 2 hours after neutralization of heparin with protamine sulfate all abnormal test results improved, but the template bleeding time was markedly prolonged in 10 patients.""?",False, +25915149,Sodium monofluorophosphate related to dental caries,1194,The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.,"Is the triple ""Sodium monofluorophosphate related to dental caries"" supported by the sentence: ""The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility.""?",False, +25861359,Sodium monofluorophosphate disrupts allergic disease,1195,Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.,"Is the triple ""Sodium monofluorophosphate disrupts allergic disease"" supported by the sentence: ""Controlled clinical comparison between a strontium chloride and a sodium monofluorophosphate toothpaste in diminishing root hypersensitivity.""?",False, +19241020,Sodium Fluoride related to gingivitis,1196,This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.,"Is the triple ""Sodium Fluoride related to gingivitis"" supported by the sentence: ""This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.""?",False, +17448182,Sodium Fluoride related to aortic valve stenosis,1197,BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.,"Is the triple ""Sodium Fluoride related to aortic valve stenosis"" supported by the sentence: ""BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.""?",False, +9111981,Sodium Fluoride related to dental caries,1198,This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.,"Is the triple ""Sodium Fluoride related to dental caries"" supported by the sentence: ""This large-scale clinical trial provides evidence of a positive statistically significant dose relationship between dental caries and sodium fluoride in a dentifrice at levels above 1100 ppm fluoride at year 1.""?",False, +25583763,Sodium Fluoride causes dental fluorosis,1199,"The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.","Is the triple ""Sodium Fluoride causes dental fluorosis"" supported by the sentence: ""The mice of the NaF group, including the mothers and newborns, were fed with water containing 150 ppm NaF after delivery to induce dental fluorosis.""?",False, +23780312,Sodium Fluoride affects dental caries,1200,OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.,"Is the triple ""Sodium Fluoride affects dental caries"" supported by the sentence: ""OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.""?",False, +18846793,Sodium Fluoride affects allergic disease,1201,"At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).","Is the triple ""Sodium Fluoride affects allergic disease"" supported by the sentence: ""At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09).""?",False, +25986070,Sodium Fluoride disrupts allergic disease,1202,"In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.","Is the triple ""Sodium Fluoride disrupts allergic disease"" supported by the sentence: ""In the allergy the functional activity of N-protein was not altered, whereas its coupling with the catalytic component was impaired by sodium fluoride.""?",False, +14286543,Sodium Fluoride prevents gingivitis,1203,"Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.","Is the triple ""Sodium Fluoride prevents gingivitis"" supported by the sentence: ""Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.""?",False, +10538561,Sodium Fluoride prevents periodontal disorder,1204,Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.,"Is the triple ""Sodium Fluoride prevents periodontal disorder"" supported by the sentence: ""Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water.""?",False, +10425615,Sodium Fluoride prevents dental caries,1205,Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.,"Is the triple ""Sodium Fluoride prevents dental caries"" supported by the sentence: ""Preparations of stannous fluoride compared with sodium fluoride for the prevention of dental caries in the rat.""?",False, +19971424,Rifaximin related to irritable bowel syndrome,1206,"In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.","Is the triple ""Rifaximin related to irritable bowel syndrome"" supported by the sentence: ""In parallel, much progress has been made in targeting low-grade inflammation, especially through the introduction of drugs such as mesalazine and rifaximin, even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.""?",False, +17053293,Rifaximin related to hepatic encephalopathy,1207,Rifaximin and lactulose have shown to be effective in HE.,"Is the triple ""Rifaximin related to hepatic encephalopathy"" supported by the sentence: ""Rifaximin and lactulose have shown to be effective in HE.""?",False, +18714048,Rifaximin causes irritable bowel syndrome,1208,"Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.","Is the triple ""Rifaximin causes irritable bowel syndrome"" supported by the sentence: ""Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the influence on gut microbiota.""?",False, +8925773,Rifaximin causes diarrheal disease,1209,"In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.","Is the triple ""Rifaximin causes diarrheal disease"" supported by the sentence: ""In vitro activity of rifaximin against bacterial enteropathogens causing diarrhoea in children under 5 years of age in Ifakara, Tanzania.""?",False, +25434952,Rifaximin affects alcoholic hepatitis,1210,"Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.","Is the triple ""Rifaximin affects alcoholic hepatitis"" supported by the sentence: ""Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.""?",False, +24257624,Rifaximin affects Infection,1211,"Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).","Is the triple ""Rifaximin affects Infection"" supported by the sentence: ""Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH).""?",False, +20149851,Rifaximin affects Crohn disease,1212,"In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.","Is the triple ""Rifaximin affects Crohn disease"" supported by the sentence: ""In conclusion, our results show that rifaximin interferes with multiple steps implicated in host-AIEC interactions related to CD, including adhesion to, and invasion of epithelial cells, virulence gene expression, motility, and pro-inflammatory cytokine secretion.""?",False, +19665399,Rifaximin affects diverticulitis,1213,The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.,"Is the triple ""Rifaximin affects diverticulitis"" supported by the sentence: ""The influence of rifaximin on diverticulitis rate and quality of life in patients with diverticulosis.""?",False, +18685028,Rifaximin affects irritable bowel syndrome,1214,AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.,"Is the triple ""Rifaximin affects irritable bowel syndrome"" supported by the sentence: ""AIM: To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action.""?",False, +16575444,Rifaximin affects hepatic encephalopathy,1215,Rifaximin may have a dramatic effect on hepatic encephalopathy.,"Is the triple ""Rifaximin affects hepatic encephalopathy"" supported by the sentence: ""Rifaximin may have a dramatic effect on hepatic encephalopathy.""?",False, +21278571,Rifaximin prevents alcoholic hepatitis,1216,"In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.","Is the triple ""Rifaximin prevents alcoholic hepatitis"" supported by the sentence: ""In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice.NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice.""?",False, +16143515,Rifaximin prevents diverticulitis,1217,No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.,"Is the triple ""Rifaximin prevents diverticulitis"" supported by the sentence: ""No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.""?",False, +15134586,Rifaximin prevents hepatic encephalopathy,1218,Gut instinct: rifaximin for the prevention of hepatic encephalopathy.,"Is the triple ""Rifaximin prevents hepatic encephalopathy"" supported by the sentence: ""Gut instinct: rifaximin for the prevention of hepatic encephalopathy.""?",False, +11830138,Rifaximin prevents irritable bowel syndrome,1219,Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.,"Is the triple ""Rifaximin prevents irritable bowel syndrome"" supported by the sentence: ""Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome.""?",False, +11830137,Rifaximin prevents diarrheal disease,1220,A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.,"Is the triple ""Rifaximin prevents diarrheal disease"" supported by the sentence: ""A study is needed in Asia to determine whether rifaximin can prevent diarrhea caused by invasive bacterial pathogens.""?",False, +15717459,Rifaximin predisposes hepatic encephalopathy,1221,This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.,"Is the triple ""Rifaximin predisposes hepatic encephalopathy"" supported by the sentence: ""This led to the approval of rifaximin for reduction of risk of recurrent HE by the US Food and Drug Administration in March 2010.""?",False, +25706307,Glycine related to cystic fibrosis,1222,Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.,"Is the triple ""Glycine related to cystic fibrosis"" supported by the sentence: ""Absorption of D-fructose and glycine demonstrated a tendency for increased net absorption in cystic fibrosis but the results were not significantly different.""?",False, +20102524,Glycine related to psychotic disorder,1223,"Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.","Is the triple ""Glycine related to psychotic disorder"" supported by the sentence: ""Similarly the activity of the enzyme serine hydroxymethyltransferase (SHMT) which cleaves serine to glycine, was significantly lower (P less than 0.0001) in psychotics than in nonpsychotics.""?",False, +17514096,Glycine related to hypertensive disorder,1224,CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.,"Is the triple ""Glycine related to hypertensive disorder"" supported by the sentence: ""CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.""?",False, +13080824,Glycine related to Alzheimer disease,1225,We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.,"Is the triple ""Glycine related to Alzheimer disease"" supported by the sentence: ""We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD.""?",False, +12589996,Glycine related to nutritional disorder,1226,Glycine production in severe childhood undernutrition.,"Is the triple ""Glycine related to nutritional disorder"" supported by the sentence: ""Glycine production in severe childhood undernutrition.""?",False, +7298031,Glycine related to schizophrenia,1227,"Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.","Is the triple ""Glycine related to schizophrenia"" supported by the sentence: ""Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.""?",False, +17397486,Glycine causes Cognitive impairment,1228,"The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.","Is the triple ""Glycine causes Cognitive impairment"" supported by the sentence: ""The increased network excitability associated with gain-of-function GlyR expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity.""?",False, +17125423,Glycine affects asthma,1229,"However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).","Is the triple ""Glycine affects asthma"" supported by the sentence: ""However, Patients in Arg/Arg (n = 8) category showed significant improvement in asthma control parameters and lung function compared with Arg/Gly genotype (n =20).""?",False, +7530162,Glycine affects schizophrenia,1230,"To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.","Is the triple ""Glycine affects schizophrenia"" supported by the sentence: ""To test the hypothesis that the high glycine concentrations observed in schizophrenics play an etiologic role in schizophrenia, an animal model was tested where rats were made hyperglycinic from life in utero to adulthood.""?",False, +12589998,Glycine produces nutritional disorder,1231,OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.,"Is the triple ""Glycine produces nutritional disorder"" supported by the sentence: ""OBJECTIVE: We aimed to measure glycine production in children with edematous and nonedematous severe childhood undernutrition.""?",False, +16845009,Glycine disrupts Alzheimer disease,1232,"[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.","Is the triple ""Glycine disrupts Alzheimer disease"" supported by the sentence: ""[Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in an ischemia stroke model.""?",False, +12278394,Glycine prevents hypertensive disorder,1233,"The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.","Is the triple ""Glycine prevents hypertensive disorder"" supported by the sentence: ""The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide.""?",False, +15546112,Glycine predisposes asthma,1234,"Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.","Is the triple ""Glycine predisposes asthma"" supported by the sentence: ""Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p = 0.025) if they did not use ICS.""?",False, +16711324,Sorbitol related to injury,1235,"CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.","Is the triple ""Sorbitol related to injury"" supported by the sentence: ""CONCLUSIONS: Sodium polystyrene sulfonate use, both with and without sorbitol, may be associated with fatal gastrointestinal injury.""?",False, +10684679,Sorbitol related to constipation disorder,1236,[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].,"Is the triple ""Sorbitol related to constipation disorder"" supported by the sentence: ""[TRIAL OF THE SORBITOL-CHOLINE COMBINATION IN CONSTIPATION OF CHILDHOOD].""?",False, +20821510,Sorbitol causes constipation disorder,1237,"However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.","Is the triple ""Sorbitol causes constipation disorder"" supported by the sentence: ""However, it is believed that sorbitol, commonly given to counteract PSP's tendency to cause constipation, may play an important role in the development of gastrointestinal injury.""?",False, +15564538,Sorbitol causes injury,1238,"Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.","Is the triple ""Sorbitol causes injury"" supported by the sentence: ""Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal.""?",False, +17658899,Sorbitol affects osteoarthritis,1239,"CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.","Is the triple ""Sorbitol affects osteoarthritis"" supported by the sentence: ""CONCLUSIONS: Altogether, our findings support a beneficial effect of HA/sorbitol in OA through the restoration of redox status and reduction of apoptosis, inflammation and catabolism involved in cartilage damage.""?",False, +26106951,Sorbitol prevents injury,1240,"Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.","Is the triple ""Sorbitol prevents injury"" supported by the sentence: ""Thus utilizing a perfusion solution containing sorbitol during loading and dilution of Me2SO reduces the osmotic injury and may greatly improve the survival prospects of cryopreserved organs by avoiding ""out-flow"" block.""?",False, +10478248,Foscarnet affects cytomegalovirus infection,1241,We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.,"Is the triple ""Foscarnet affects cytomegalovirus infection"" supported by the sentence: ""We conclude that foscarnet is nephrotoxic but otherwise well tolerated with moderate clinical and virostatic effects on CMV infection.""?",False, +10481132,Foscarnet prevents cytomegalovirus infection,1242,The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.,"Is the triple ""Foscarnet prevents cytomegalovirus infection"" supported by the sentence: ""The safety and efficacy of foscarnet for prevention of cytomegalovirus (CMV) infection was evaluated in 19 CMV-seropositive bone marrow transplant (BMT) recipients.""?",False, +22857734,Atogepant prevents migraine disorder,1243,"Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.","Is the triple ""Atogepant prevents migraine disorder"" supported by the sentence: ""Areas covered : This paper reviews the available data from RCTs to assess the clinical efficacy, safety, and tolerability profile of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine and atogepant for the prevention of migraine.""?",False, +25325960,Rimegepant prevents migraine disorder,1244,"As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.","Is the triple ""Rimegepant prevents migraine disorder"" supported by the sentence: ""As the first dual agent approved for both treatment and prevention of migraine, rimegepant represents a useful option for the management of migraine in adults.""?",False, +21939131,Rimegepant prevents Pain,1245,"The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.","Is the triple ""Rimegepant prevents Pain"" supported by the sentence: ""The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo.""?",False, +10553741,ATROPINE related to poisoning,1246,"[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].","Is the triple ""ATROPINE related to poisoning"" supported by the sentence: ""[Combined ACTH, chlorpromazine and atropine in phosphoric ester poisoning].""?",False, +19468294,ATROPINE causes Pain,1247,"In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.","Is the triple ""ATROPINE causes Pain"" supported by the sentence: ""In reality, they were randomized double blind, double-dummy to 1 of the 4 conditions: (1) 100 mg diclofenac + 1.2 mg atropine, (2) placebo + 1.2 mg atropine, (3) 100 mg diclofenac + placebo, or (4) placebo + placebo, and tested with heat-induced pain.""?",False, +18989245,ATROPINE causes digestive system disorder,1248,"With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.","Is the triple ""ATROPINE causes digestive system disorder"" supported by the sentence: ""With gastric retention rate, rate of small intestine propulsion, serum content of GAS and MTL as indexes to evaluate the curing effect on gastrointestinal movement disorders caused by atropine in mice.""?",False, +14576640,ATROPINE causes myopia,1249,"PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.","Is the triple ""ATROPINE causes myopia"" supported by the sentence: ""PURPOSE: Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development.""?",False, +10716177,ATROPINE causes Mydriasis,1250,"The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.","Is the triple ""ATROPINE causes Mydriasis"" supported by the sentence: ""The three antimuscarinic agents, at doses that inhibited colonic spike activity by approximately 80% (equiactive doses), behaved as follows on heart rate and pupil diameter: atropine induced tachycardia and mydriasis, telenzepine had no effect, and DF594 induced slight mydriasis with no effect on heart rate.""?",False, +10361041,ATROPINE causes amblyopia,1251,"OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.","Is the triple ""ATROPINE causes amblyopia"" supported by the sentence: ""OBJECTIVE: To assess whether the relative treatment effect of patching compared with atropine for moderate amblyopia varies according to patient age, cause of amblyopia or depth of amblyopia, and initial number of patching hours prescribed.""?",False, +9746341,ATROPINE causes poisoning,1252,"Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.","Is the triple ""ATROPINE causes poisoning"" supported by the sentence: ""Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action.""?",False, +9301311,ATROPINE causes cardiac arrest,1253,"Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.","Is the triple ""ATROPINE causes cardiac arrest"" supported by the sentence: ""Because of episodic slowing of the heart rate below 40 beats/min, he received 1 mg atropine intravenously which increased the atrial rate but further worsened the AV conduction, resulting in ventricular asystole for more than 30 seconds associated with loss of consciousness and seizure-like activity.""?",False, +8524259,ATROPINE causes Insulin resistance,1254,Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.,"Is the triple ""ATROPINE causes Insulin resistance"" supported by the sentence: ""Dose-related atropine-induced insulin resistance: comparing intraportal versus intravenous administration.""?",False, +8480152,ATROPINE causes Bradycardia,1255,In 6-week-old rats atropine produced bradycardia instead of tachycardia.,"Is the triple ""ATROPINE causes Bradycardia"" supported by the sentence: ""In 6-week-old rats atropine produced bradycardia instead of tachycardia.""?",False, +26343406,ATROPINE affects hypoglycemia,1256,"3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""3) Under the above conditions, the hPP response to hypoglycemia can be blocked by atropine, thus indicating that it is due to activation of the cholinergic system and not to the direct effect of glucose lack at the level of the hPP-cell.""?",False, +23118209,ATROPINE affects Mydriasis,1257,Both im and iv atropine had similar effects on weight loss rate and mydriasis.,"Is the triple ""ATROPINE affects Mydriasis"" supported by the sentence: ""Both im and iv atropine had similar effects on weight loss rate and mydriasis.""?",False, +19520979,ATROPINE affects hypoglycemia,1258,"The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.","Is the triple ""ATROPINE affects hypoglycemia"" supported by the sentence: ""The ACTH response to hypoglycaemia did not change after pirenzepine administration, whereas it was significantly increased by atropine and decreased by trimethaphan treatment.""?",False, +12406813,ATROPINE affects cardiac arrest,1259,Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.,"Is the triple ""ATROPINE affects cardiac arrest"" supported by the sentence: ""Cardiac arrest with bradycardia poorly responsive to adrenaline and responsive to high dose atropine should alert the clinician to the possibility of an anticholinesterase poisoning.""?",False, +11741867,ATROPINE affects Bradycardia,1260,"LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""LDA elicited bradycardia and significantly increased high-frequency (HF, 0.15-0.4 Hz) power of HRV and spontaneous BRS, as determined by transfer function analysis.""?",False, +10264479,ATROPINE affects Hemorrhage,1261,"Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.","Is the triple ""ATROPINE affects Hemorrhage"" supported by the sentence: ""Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage.""?",False, +9293832,ATROPINE affects poisoning,1262,"Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.","Is the triple ""ATROPINE affects poisoning"" supported by the sentence: ""Atropine can dry secretions, but is not recommended for stings from many foreign scorpions, since it exacerbates adrenergic toxicity to the cardiopulmonary system.""?",False, +9041302,ATROPINE affects Bradycardia,1263,"This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""This bradycardic effect was blocked by atropine and atenolol, and did not occur in vitro.""?",False, +7845760,ATROPINE affects Bradycardia,1264,"CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.","Is the triple ""ATROPINE affects Bradycardia"" supported by the sentence: ""CONCLUSION AND CLINICAL RELEVANCE: In Greyhounds which were not undergoing any surgical stimulation, total intravenous anesthesia maintained with propofol and fentanyl infusions induced satisfactory anesthesia, provided atropine was given to counteract bradycardia.""?",False, +7111083,ATROPINE affects myopia,1265,"These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.","Is the triple ""ATROPINE affects myopia"" supported by the sentence: ""These results suggest that all three concentrations of atropine had significant effects on controlling myopia; however, treatment with 0.5% atropine was the most effective.""?",False, +26141463,ATROPINE disrupts hypoglycemia,1266,The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.,"Is the triple ""ATROPINE disrupts hypoglycemia"" supported by the sentence: ""The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients.""?",False, +23143978,ATROPINE disrupts poisoning,1267,"Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.","Is the triple ""ATROPINE disrupts poisoning"" supported by the sentence: ""Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol.""?",False, +20133204,ATROPINE disrupts Pain,1268,Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?,"Is the triple ""ATROPINE disrupts Pain"" supported by the sentence: ""Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?""?",False, +18168420,ATROPINE disrupts Bradycardia,1269,"After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.","Is the triple ""ATROPINE disrupts Bradycardia"" supported by the sentence: ""After atropine, phenoxybenzamine or phentolamine, alinidine remained without effect on mean blood pressure, but after pindolol or yohimbine, a hypotensive effect appeared concomitantly with the reduction of the ventricular bradycardia.""?",False, +7111084,ATROPINE disrupts myopia,1270,"Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.","Is the triple ""ATROPINE disrupts myopia"" supported by the sentence: ""Although 1% atropine effectively slows myopia progression, it is associated with adverse effects, including photophobia, blurred near vision, and poor compliance.""?",False, +9676858,ATROPINE prevents poisoning,1271,Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.,"Is the triple ""ATROPINE prevents poisoning"" supported by the sentence: ""Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration.""?",False, +9198373,ATROPINE prevents myopia,1272,"One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.","Is the triple ""ATROPINE prevents myopia"" supported by the sentence: ""One excitatory retinal neurotransmitter, acetylcholine, has been implicated in the signal cascade through the effectiveness of the muscarinic antagonist, atropine, in preventing myopia development.""?",False, +8451883,ATROPINE prevents cardiac arrest,1273,Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.,"Is the triple ""ATROPINE prevents cardiac arrest"" supported by the sentence: ""Pretreatment with atropine can prevent asystole without inducing hazardous tachyarrhythmia.""?",False, +23699298,ATROPINE predisposes myopia,1274,"Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).","Is the triple ""ATROPINE predisposes myopia"" supported by the sentence: ""Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014).""?",False, +14640163,ATROPINE predisposes poisoning,1275,"A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.","Is the triple ""ATROPINE predisposes poisoning"" supported by the sentence: ""A combination of atropine and glycopyrrolate in equivalent dosages titrated to the peripheral muscarinic signs, theoretically reduces the central effect of the anticholinergics by 50% and thereby the risk of central toxicity, while it provides effective control of the peripheral manifestations of OPP.""?",False, +7953996,Tolcapone affects Parkinson disease,1276,"Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.","Is the triple ""Tolcapone affects Parkinson disease"" supported by the sentence: ""Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue.""?",False, +15643297,Entacapone related to Parkinson disease,1277,OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.,"Is the triple ""Entacapone related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.""?",False, +10033650,Entacapone causes Parkinson disease,1278,"Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.","Is the triple ""Entacapone causes Parkinson disease"" supported by the sentence: ""Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.""?",False, +15952178,Entacapone affects Parkinson disease,1279,Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.,"Is the triple ""Entacapone affects Parkinson disease"" supported by the sentence: ""Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.""?",False, +20308336,Entacapone disrupts Parkinson disease,1280,"Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).","Is the triple ""Entacapone disrupts Parkinson disease"" supported by the sentence: ""Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD).""?",False, +25394620,Veliparib affects neoplasm,1281,"[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).","Is the triple ""Veliparib affects neoplasm"" supported by the sentence: ""[ 11 C]PyBic demonstrated PARP-specific binding in RG2 tumors, with 74% of tracer binding in tumors blocked by preinjected veliparib (i.v., 5 mg/kg).""?",False, +21697473,Veliparib affects triple-negative breast carcinoma,1282,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Veliparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, +21882624,Talazoparib causes neoplasm,1283,"In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.","Is the triple ""Talazoparib causes neoplasm"" supported by the sentence: ""In summary, our findings reveal the molecular mechanism of talazoparib-induced anti-tumor effect, and suggest a potential clinical use of talazoparib-targeted lncRNA PLK4/YAP-dependent cellular senescence for the treatment of HCC.""?",False, +22572154,Talazoparib affects neoplasm,1284,The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.,"Is the triple ""Talazoparib affects neoplasm"" supported by the sentence: ""The in vivo experiments confirmed the clinical impact of talazoparib on MF tumors.""?",False, +21697476,Talazoparib affects triple-negative breast carcinoma,1285,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Talazoparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, +22916819,Talazoparib prevents neoplasm,1286,Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.,"Is the triple ""Talazoparib prevents neoplasm"" supported by the sentence: ""Future studies will directly evaluate the effects of InCeT-TLZ for preventing tumor development.""?",False, +24451977,Olaparib related to triple-negative breast carcinoma,1287,"Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.","Is the triple ""Olaparib related to triple-negative breast carcinoma"" supported by the sentence: ""Hence, we evaluated the radiosensitization and the underlying mechanism of combination treatment with OA and olaparib in TNBC.""?",False, +25473017,Olaparib causes pancreatic ductal adenocarcinoma,1288,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes pancreatic ductal adenocarcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, +25473016,Olaparib causes non-small cell lung carcinoma,1289,We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.,"Is the triple ""Olaparib causes non-small cell lung carcinoma"" supported by the sentence: ""We demonstrated that high concentrations of AF and olaparib synergistically induced cytotoxicity in NSCLC and PDAC cell lines with low levels of mutant p53 protein that were initially more resistant to AF.""?",False, +22160122,Olaparib causes head and neck neoplasm,1290,"Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.","Is the triple ""Olaparib causes head and neck neoplasm"" supported by the sentence: ""Moreover, olaparib plus AZD6738 administration concomitant with IR even worsened the response to radiation of head and neck orthotopic tumours and induced mucositis.""?",False, +24770500,Olaparib affects castration-resistant prostate carcinoma,1291,Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.,"Is the triple ""Olaparib affects castration-resistant prostate carcinoma"" supported by the sentence: ""Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.""?",False, +24672020,Olaparib affects prostate cancer,1292,"Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.","Is the triple ""Olaparib affects prostate cancer"" supported by the sentence: ""Increasing evidence suggests that the PARP inhibitor olaparib could have a significant synthetic lethal effect in prostate cancer with homologous recombination defects, such as BRCA1/2 mutations.""?",False, +22977330,Olaparib affects neoplasm,1293,TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.,"Is the triple ""Olaparib affects neoplasm"" supported by the sentence: ""TBCRC 048 evaluated the role of olaparib in homologous recombination deficient tumours due to genomic alterations other than germline BRCA1/2 mutations; clinically relevant activity was reported in patients with germline PALB2 and somatic BRCA1/2 mutations.""?",False, +21697474,Olaparib affects triple-negative breast carcinoma,1294,"CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).","Is the triple ""Olaparib affects triple-negative breast carcinoma"" supported by the sentence: ""CST shows prominent features of BRCA1-mutated triple-negative breast cancers including increased motility, high proliferation rate, genome instability and sensitivity to platinum chemotherapy and PARP inhibitors (olaparib, veliparib, rucaparib and talazoparib).""?",False, +24201965,Olaparib prevents Neoplasm Metastasis,1295,The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.,"Is the triple ""Olaparib prevents Neoplasm Metastasis"" supported by the sentence: ""The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.""?",False, +27698235,Capsaicin related to arthritic joint disease,1296,"Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.","Is the triple ""Capsaicin related to arthritic joint disease"" supported by the sentence: ""Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy.""?",False, +22276323,Capsaicin related to herpes zoster,1297,Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.,"Is the triple ""Capsaicin related to herpes zoster"" supported by the sentence: ""Effects of topical capsaicin on normal skin and affected dermatomes in herpes zoster.""?",False, +13200623,Capsaicin related to migraine disorder,1298,Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.,"Is the triple ""Capsaicin related to migraine disorder"" supported by the sentence: ""Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.""?",False, +11537529,Capsaicin related to Cough,1299,"Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.","Is the triple ""Capsaicin related to Cough"" supported by the sentence: ""Patients with acute upper respiratory tract infection (URTI) have been shown to be hyperreactive to inhaled tussigens such as citric acid and capsaicin, and the authors propose that this may be due to an increased sensitivity of airway receptors that mediate cough.""?",False, +10028696,Capsaicin related to diabetic neuropathy,1300,"CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.","Is the triple ""Capsaicin related to diabetic neuropathy"" supported by the sentence: ""CONCLUSIONS: Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy.""?",False, +8608120,Capsaicin related to osteoarthritis,1301,The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.,"Is the triple ""Capsaicin related to osteoarthritis"" supported by the sentence: ""The study showed that topical capsaicin and glyceryl trinitrate have an analgesic effect in painful osteoarthritis.""?",False, +8470968,Capsaicin related to postherpetic neuralgia,1302,"These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.","Is the triple ""Capsaicin related to postherpetic neuralgia"" supported by the sentence: ""These studies have been important in confirming the efficacy of antidepressants, antiepileptics, local anesthetics and derivatives, capsaicin, opioids, and N-methyl-D-aspartate antagonists in neuropathic pain, specifically painful diabetic neuropathy and postherpetic neuralgia.""?",False, +8246278,Capsaicin related to neuralgia,1303,3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.,"Is the triple ""Capsaicin related to neuralgia"" supported by the sentence: ""3% doxepin and 0.025% capsaicin in human chronic neuropathic pain.""?",False, +7965643,Capsaicin related to Pruritus,1304,"As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).","Is the triple ""Capsaicin related to Pruritus"" supported by the sentence: ""As serotonin is proposed to play a pathophysiological role in some types of pruritus (e.g. uremic and hepatic pruritus) and CAP has been described to be successful in hemodialysis-related pruritus, we investigated the antipruritic effect of topical CAP on serotonin-induced reactions in 10 healthy volunteers in comparison to untreated skin (UPS) and placebo substance (vehicle)-treated skin (VS).""?",False, +7239245,Capsaicin related to Pain,1305,Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.,"Is the triple ""Capsaicin related to Pain"" supported by the sentence: ""Topical capsaicin and oral amitriptyline produced equal and statistically significant improvements in pain over the course of the study.""?",False, +26554289,Capsaicin causes stroke disorder,1306,MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.,"Is the triple ""Capsaicin causes stroke disorder"" supported by the sentence: ""MX2/120 is significantly more active and long-lasting than theophylline in in vivo experiments toward spasmogens such as acetylcholine (ED50 over 5 h = 15 mumol/kg p.o. vs 230 mumol/kg p.o.) or histamine (ED50 over 5 h = 122 mumol/kg p.o. vs 500 mumol/kg p.o.) while being almost equiactive to theophylline toward antigen and capsaicin induced cough strokes.""?",False, +24505933,Capsaicin causes Muscle spasm,1307,"The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.","Is the triple ""Capsaicin causes Muscle spasm"" supported by the sentence: ""The administration of capsaicin causes stomach cramps, gastrointestinal irritation, gut pain and vomiting in patients.""?",False, +18391785,Capsaicin causes neuralgia,1308,Can topical capsaicin induce a neuropathic pain?,"Is the triple ""Capsaicin causes neuralgia"" supported by the sentence: ""Can topical capsaicin induce a neuropathic pain?""?",False, +16420383,Capsaicin causes migraine disorder,1309,CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.,"Is the triple ""Capsaicin causes migraine disorder"" supported by the sentence: ""CONCLUSIONS: Age-dependent differences in TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are reminiscent of less severe migraine in pediatric patients.""?",False, +11163813,Capsaicin causes arthritic joint disease,1310,Capsaicin-induced joint inflammation is not blocked by local anesthesia.,"Is the triple ""Capsaicin causes arthritic joint disease"" supported by the sentence: ""Capsaicin-induced joint inflammation is not blocked by local anesthesia.""?",False, +9650510,Capsaicin causes Myalgia,1311,Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.,"Is the triple ""Capsaicin causes Myalgia"" supported by the sentence: ""Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.""?",False, +8975038,Capsaicin causes Vomiting,1312,"E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).","Is the triple ""Capsaicin causes Vomiting"" supported by the sentence: ""E-capsaicin-induced emesis was antagonised by capsazepine (300-600 nmol, i.c.v.; P<0.05) and ruthenium red (3 nmol, i.c.v.; P<0.05) but resiniferatoxin-induced emesis was resistant to capsazepine (30-600 nmol, i.c.v.; P>0.05).""?",False, +8261437,Capsaicin causes Cough,1313,The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.,"Is the triple ""Capsaicin causes Cough"" supported by the sentence: ""The aim was to study cough and other capsaicin-induced symptoms and to test the effect of a drug (lidocaine) that inhibits nerve transmission in sensory nerves.""?",False, +7430731,Capsaicin causes Pruritus,1314,"Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.","Is the triple ""Capsaicin causes Pruritus"" supported by the sentence: ""Capsaicin applied topically to human skin produces itching, pricking and burning sensations due to excitation of nociceptors.""?",False, +7414435,Capsaicin causes Pain,1315,Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.,"Is the triple ""Capsaicin causes Pain"" supported by the sentence: ""Topical EMLA pre-treatment fails to decrease the pain induced by 1% topical capsaicin.""?",False, +27524804,Capsaicin affects arthritic joint disease,1316,Effects of capsaicin in temporomandibular joint arthritis in rats.,"Is the triple ""Capsaicin affects arthritic joint disease"" supported by the sentence: ""Effects of capsaicin in temporomandibular joint arthritis in rats.""?",False, +25438971,Capsaicin affects brain injury,1317,"Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.","Is the triple ""Capsaicin affects brain injury"" supported by the sentence: ""Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated.""?",False, +19404541,Capsaicin affects neuroma,1318,"There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.","Is the triple ""Capsaicin affects neuroma"" supported by the sentence: ""There was a slight increase in the incidence of spontaneous activity, but not excitation by capsaicin, with increasing age of the neuromas.""?",False, +15791019,Capsaicin affects Pruritus,1319,"A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis).""?",False, +10951234,Capsaicin affects stroke disorder,1320,"Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.","Is the triple ""Capsaicin affects stroke disorder"" supported by the sentence: ""Furthermore, nearly all STT neurons exhibited vigorous and persistent responses to capsaicin, after which they became sensitized to stroking and to punctate stimulation.""?",False, +10764355,Capsaicin affects Pain,1321,"Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Because the sensation for capsaicin is associated with perception of pain, this genetic study on different capsaicin sensitivities will help future analyses of endogenous analgesic pathway.""?",False, +10290167,Capsaicin affects Pruritus,1322,"As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.","Is the triple ""Capsaicin affects Pruritus"" supported by the sentence: ""As shown in previous experimental studies, topical capsaicin has a strong inhibitory effect in histamine-induced itch in healthy persons, but not in patients with atopic eczema.""?",False, +10171204,Capsaicin affects neuralgia,1323,"Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.","Is the triple ""Capsaicin affects neuralgia"" supported by the sentence: ""Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.""?",False, +8975035,Capsaicin affects Vomiting,1324,The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.,"Is the triple ""Capsaicin affects Vomiting"" supported by the sentence: ""The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus.""?",False, +8515286,Capsaicin affects Pain,1325,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects Pain"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, +8515285,Capsaicin affects postherpetic neuralgia,1326,"Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.","Is the triple ""Capsaicin affects postherpetic neuralgia"" supported by the sentence: ""Compared to mirror-image skin, applying capsaicin on a 9 cm(2) area of PHN skin significantly increased overall PHN pain and allodynia in 11 of 17 subjects.""?",False, +8441743,Capsaicin affects Cough,1327,Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Guinea-pigs were anaesthetized and exposed to an aerosol of capsaicin (100 microM) to elicit coughing.""?",False, +7281158,Capsaicin affects Cough,1328,Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.,"Is the triple ""Capsaicin affects Cough"" supported by the sentence: ""Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.""?",False, +18283970,Capsaicin disrupts Pain,1329,"Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.","Is the triple ""Capsaicin disrupts Pain"" supported by the sentence: ""Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.""?",False, +17652809,Capsaicin disrupts arthritic joint disease,1330,Capsaicin suppresses substance P-induced joint inflammation in the rat.,"Is the triple ""Capsaicin disrupts arthritic joint disease"" supported by the sentence: ""Capsaicin suppresses substance P-induced joint inflammation in the rat.""?",False, +14643733,Capsaicin disrupts breast neoplasm,1331,"Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.","Is the triple ""Capsaicin disrupts breast neoplasm"" supported by the sentence: ""Besides, capsaicin potently inhibited the development of pre-neoplastic breast lesions by up to 80% without evidence of toxicity.""?",False, +9869751,Capsaicin disrupts Cough,1332,"To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.","Is the triple ""Capsaicin disrupts Cough"" supported by the sentence: ""To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 x 10-4 m capsaicin.""?",False, +8160008,Capsaicin disrupts Pruritus,1333,RESULTS: Capsaicin suppressed completely itch in all patients.,"Is the triple ""Capsaicin disrupts Pruritus"" supported by the sentence: ""RESULTS: Capsaicin suppressed completely itch in all patients.""?",False, +25438980,Capsaicin prevents brain injury,1334,Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.,"Is the triple ""Capsaicin prevents brain injury"" supported by the sentence: ""Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.""?",False, +20404597,Capsaicin prevents postherpetic neuralgia,1335,The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.,"Is the triple ""Capsaicin prevents postherpetic neuralgia"" supported by the sentence: ""The life long burden of suffering from postherpetic neuralgia is reduced by adult vaccination and by topical anti-hyperalgesic treatment with lidocaine and capsaicin.""?",False, +17168513,Capsaicin prevents migraine disorder,1336,"Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.","Is the triple ""Capsaicin prevents migraine disorder"" supported by the sentence: ""Several studies have reported that capsaicin is effective in relief and prevention of migraine headaches, improves digestion, helps to prevent heart disease, and lowers blood cholesterol and blood pressure levels.""?",False, +16978917,Capsaicin prevents neuralgia,1337,Capsaicin treatment is one method to reduce neuropathic pain.,"Is the triple ""Capsaicin prevents neuralgia"" supported by the sentence: ""Capsaicin treatment is one method to reduce neuropathic pain.""?",False, +15822967,Capsaicin prevents stroke disorder,1338,We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).,"Is the triple ""Capsaicin prevents stroke disorder"" supported by the sentence: ""We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).""?",False, +10290168,Capsaicin prevents Pruritus,1339,"In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.","Is the triple ""Capsaicin prevents Pruritus"" supported by the sentence: ""In both groups, itching was not significantly reduced by capsaicin compared to untreated skin.""?",False, +8608117,Capsaicin prevents osteoarthritis,1340,The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.,"Is the triple ""Capsaicin prevents osteoarthritis"" supported by the sentence: ""The aim of this study was to assess if the pain of osteoarthritis is reduced by topical capsaicin and to determine whether addition of glyceryl trinitrate has an effect on analgesic efficacy and tolerability of capsaicin.""?",False, +8246280,Capsaicin prevents Pain,1341,"RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.","Is the triple ""Capsaicin prevents Pain"" supported by the sentence: ""RESULTS: Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent.""?",False, +14706687,Capsaicin predisposes Pain,1342,These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.,"Is the triple ""Capsaicin predisposes Pain"" supported by the sentence: ""These results demonstrate that nociceptors desensitized by capsaicin contribute to heat hyperalgesia and guarding pain after plantar incision.""?",False, +24021484,Nusinersen causes spinal muscular atrophy,1343,"Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.","Is the triple ""Nusinersen causes spinal muscular atrophy"" supported by the sentence: ""Moreover, these data highlight the importance of addressing astrocyte health and response to nusinersen in SMA pathogenesis and treatment strategies.""?",False, +22907909,Nusinersen affects spinal muscular atrophy,1344,More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.,"Is the triple ""Nusinersen affects spinal muscular atrophy"" supported by the sentence: ""More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA.""?",False, +27681284,Hyaluronic acid sodium salt related to alcoholic hepatitis,1345,"These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.","Is the triple ""Hyaluronic acid sodium salt related to alcoholic hepatitis"" supported by the sentence: ""These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.""?",False, +26794689,Hyaluronic acid sodium salt related to carpal tunnel syndrome,1346,"In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.","Is the triple ""Hyaluronic acid sodium salt related to carpal tunnel syndrome"" supported by the sentence: ""In this study, CTS might be associated with increased serum concentrations of HA, and HA production might be mediated by IL-6.""?",False, +20903427,Hyaluronic acid sodium salt related to Skin ulcer,1347,Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.,"Is the triple ""Hyaluronic acid sodium salt related to Skin ulcer"" supported by the sentence: ""Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers.""?",False, +18915649,Hyaluronic acid sodium salt related to Hyaluronidase,1348,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, +18915649,Hyaluronic acid sodium salt related to Hyaluronidase,1349,"Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""Compared to other haematophagous insects, the ability of tabanid hyases to hydrolyze hyaluronic acid (HA) is extremely high, for example the enzyme activity of Hybomitra muehlfeldi was found to be 32-fold higher than the salivary hyase activity of the sand fly Phlebotomus papatasi.""?",False, +15362486,Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder,1350,OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.,"Is the triple ""Hyaluronic acid sodium salt related to intervertebral disc degenerative disorder"" supported by the sentence: ""OBJECTIVE: To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both biomechanical and biologic parameters.""?",False, +14268478,Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease,1351,Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.,"Is the triple ""Hyaluronic acid sodium salt related to chronic obstructive pulmonary disease"" supported by the sentence: ""Our results indicate that there is a decreased expression of HA in asthma and COPD associated with a synergistic regulation of HA metabolising enzymes that may regulate the pathological airway remodelling in these lung diseases.""?",False, +9147590,Hyaluronic acid sodium salt related to dry eye syndrome,1352,Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.,"Is the triple ""Hyaluronic acid sodium salt related to dry eye syndrome"" supported by the sentence: ""Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca.""?",False, +7458117,Hyaluronic acid sodium salt related to osteoarthritis,1353,OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.,"Is the triple ""Hyaluronic acid sodium salt related to osteoarthritis"" supported by the sentence: ""OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee.""?",False, +17074499,Hyaluronic acid sodium salt related to Hyaluronidase,1354,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, +17074499,Hyaluronic acid sodium salt related to Hyaluronidase,1355,"These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.","Is the triple ""Hyaluronic acid sodium salt related to Hyaluronidase"" supported by the sentence: ""These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to non-modified HA.""?",False, +12401778,Hyaluronic acid sodium salt has part Hyaluronidase,1356,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, +12401778,Hyaluronic acid sodium salt has part Hyaluronidase,1357,"The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.","Is the triple ""Hyaluronic acid sodium salt has part Hyaluronidase"" supported by the sentence: ""The activity of hyaluronidase was shown to be up-regulated by hypoxia and, further, could carry out the function of processing HA into SMW.""?",False, +11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,1358,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, +11319224,Hyaluronic acid sodium salt coexists with Hyaluronidase,1359,"HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.","Is the triple ""Hyaluronic acid sodium salt coexists with Hyaluronidase"" supported by the sentence: ""HA and HA-collagen hydrogels degrade in the presence of hyaluronidase and collagenase enzymes, indicating that the chemical modification does not prevent biodegradation.""?",False, +7287149,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,1360,The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""The interaction of hyaluronidase with HA results in the disruption of basement membrane integrity and produces an angiogenic response that has been implicated in tumor invasiveness and metastasis.""?",False, +7699622,Hyaluronic acid sodium salt physically interacts with Hyaluronidase,1361,Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.,"Is the triple ""Hyaluronic acid sodium salt physically interacts with Hyaluronidase"" supported by the sentence: ""Hyaluronan synthesis was also enhanced in plasma membranes from fibroblasts that had been treated with hyaluronidase or trypsin.""?",False, +12146167,Hyaluronic acid sodium salt causes osteoarthritis,1362,We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).,"Is the triple ""Hyaluronic acid sodium salt causes osteoarthritis"" supported by the sentence: ""We hypothesized that a combined therapy with US and HA would have synergistic effects on alleviating the pathogenesis of osteoarthritis (OA).""?",False, +8938037,Hyaluronic acid sodium salt affects osteoarthritis,1363,"RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.","Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""RESULTS: The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.""?",False, +8541022,Hyaluronic acid sodium salt affects osteoarthritis,1364,The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.,"Is the triple ""Hyaluronic acid sodium salt affects osteoarthritis"" supported by the sentence: ""The purpose of this review is to discuss cellular and immunologic effects of HA that could affect OA progression and to present data from a clinical trial that evaluated HA structural effects.""?",False, +7683831,Hyaluronic acid sodium salt affects Hyaluronidase,1365,Such small HA fragments are generated from the degradation of HA by hyaluronidase.,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""Such small HA fragments are generated from the degradation of HA by hyaluronidase.""?",False, +7895314,Hyaluronic acid sodium salt affects Hyaluronidase,1366,RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).,"Is the triple ""Hyaluronic acid sodium salt affects Hyaluronidase"" supported by the sentence: ""RESULTS: Hyaluronidase was found to reduce the hyaluronan contents of the grafts from 586+/-52 microg/g in control animals receiving vehicle infusion to 161+/-48 microg/g (p < 0.001) and the water contents from 81.3+/-0.4 x 10(-2) U to 79.7+/-0.4 x 10(-2) U (p < 0.05).""?",False, +18839068,Hyaluronic acid sodium salt produces Hyaluronidase,1367,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, +18839068,Hyaluronic acid sodium salt produces Hyaluronidase,1368,"Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Hyaluronidase production was detected by growing isolates on BHI agar containing 400 MUg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype.""?",False, +9813251,Hyaluronic acid sodium salt produces Hyaluronidase,1369,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, +9813251,Hyaluronic acid sodium salt produces Hyaluronidase,1370,"Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.","Is the triple ""Hyaluronic acid sodium salt produces Hyaluronidase"" supported by the sentence: ""Here we report that dendritic cells (DC) express mRNAs for HA synthases and hyaluronidases, actively synthesize HA, and display HA on their surfaces.""?",False, +17165364,Hyaluronic acid sodium salt has input Hyaluronidase,1371,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, +17165364,Hyaluronic acid sodium salt has input Hyaluronidase,1372,These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.,"Is the triple ""Hyaluronic acid sodium salt has input Hyaluronidase"" supported by the sentence: ""These results suggest that changes in the expression of HA can be epileptogenic and that hyaluronidase treatment in vitro provides a robust model for the dissection of the underlying mechanisms.""?",False, +23839601,Hyaluronic acid sodium salt disrupts dry eye syndrome,1373,Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.,"Is the triple ""Hyaluronic acid sodium salt disrupts dry eye syndrome"" supported by the sentence: ""Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease.""?",False, +22764727,Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder,1374,"Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.","Is the triple ""Hyaluronic acid sodium salt disrupts intervertebral disc degenerative disorder"" supported by the sentence: ""Our results demonstrated that HA could potentially suppress IVDD by regulating p38 and Erk1/2 pathways, and that the expression of HYAL1 were correlated with IVDD progression.""?",False, +7155073,Hyaluronic acid sodium salt disrupts osteoarthritis,1375,"Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.","Is the triple ""Hyaluronic acid sodium salt disrupts osteoarthritis"" supported by the sentence: ""Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints.""?",False, +18262848,Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease,1376,Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.,"Is the triple ""Hyaluronic acid sodium salt prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.""?",False, +11511344,Hyaluronic acid sodium salt prevents osteoarthritis,1377,The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.,"Is the triple ""Hyaluronic acid sodium salt prevents osteoarthritis"" supported by the sentence: ""The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis.""?",False, +21264578,Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder,1378,"CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.","Is the triple ""Hyaluronic acid sodium salt predisposes intervertebral disc degenerative disorder"" supported by the sentence: ""CONCLUSION: Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.""?",False, +11605823,Hyaluronic acid sodium salt predisposes osteoarthritis,1379,CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.,"Is the triple ""Hyaluronic acid sodium salt predisposes osteoarthritis"" supported by the sentence: ""CONCLUSION: These cross-sectional data support a role for serum HA as a biomarker of radiographic OA.""?",False, +24659748,Zoledronic acid related to osteoporosis,1380,"Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.","Is the triple ""Zoledronic acid related to osteoporosis"" supported by the sentence: ""Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP.""?",False, +18902207,Zoledronic acid causes Marchiafava-Bignami disease,1381,Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.,"Is the triple ""Zoledronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice.""?",False, +18856931,Zoledronic acid causes hepatocellular carcinoma,1382,"This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.","Is the triple ""Zoledronic acid causes hepatocellular carcinoma"" supported by the sentence: ""This killing activity was partly inhibited by mevastatin, an inhibitor of the mevalonate pathway, and markedly reduced by a monoclonal antibody to gamma- and delta-chain T cell receptor, indicating that this is crucial for Zol-induced HCC killing.""?",False, +13083414,Zoledronic acid causes bone fracture,1383,"The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.","Is the triple ""Zoledronic acid causes bone fracture"" supported by the sentence: ""The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.""?",False, +21044659,Zoledronic acid affects Marchiafava-Bignami disease,1384,Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.,"Is the triple ""Zoledronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""Effect of Zoledronate on Bone Loss After Romosozumab/Denosumab: 2-Year Follow-up.""?",False, +19059032,Zoledronic acid affects bone osteosarcoma,1385,"BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.","Is the triple ""Zoledronic acid affects bone osteosarcoma"" supported by the sentence: ""BACKGROUND: Based on preclinical data for the antitumour effect of zoledronate in osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery improved event-free survival in children and adults with osteosarcoma.""?",False, +13892047,Zoledronic acid affects bone fracture,1386,Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.,"Is the triple ""Zoledronic acid affects bone fracture"" supported by the sentence: ""Ibandronate and zoledronate are permitted to use by injection in the treatment of osteoporosis in US and Europe and have shown a significant effect in fracture prevention.""?",False, +13448998,Zoledronic acid affects osteonecrosis,1387,"Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.","Is the triple ""Zoledronic acid affects osteonecrosis"" supported by the sentence: ""Accordingly, a diagnosis of possible delayed onset jaw osteonecrosis associated with zoledronate was made.""?",False, +9617769,Zoledronic acid affects osteoporosis,1388,Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.,"Is the triple ""Zoledronic acid affects osteoporosis"" supported by the sentence: ""Zoledronate once-yearly increases bone mineral density--implications for osteoporosis.""?",False, +24472422,Zoledronic acid disrupts sarcoma,1389,Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.,"Is the triple ""Zoledronic acid disrupts sarcoma"" supported by the sentence: ""Background zoledronate suppresses human sarcomas by blocking the formation of geranylgeranyl diphosphate (GGPP) via inhibiting GGPP synthase.""?",False, +20879055,Zoledronic acid disrupts Neoplasm Metastasis,1390,"Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.","Is the triple ""Zoledronic acid disrupts Neoplasm Metastasis"" supported by the sentence: ""Using the same low-dose and longer time course for treatment, we demonstrate that 10 uM zol also significantly inhibits tumor cell migration and 3D-cell growth/invasion.""?",False, +20879053,Zoledronic acid disrupts Pain,1391,Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.,"Is the triple ""Zoledronic acid disrupts Pain"" supported by the sentence: ""Background: Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain.""?",False, +13311906,Zoledronic acid disrupts hepatocellular carcinoma,1392,"Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.","Is the triple ""Zoledronic acid disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment of tumor cells by the mevalonate pathway inhibitor, zoledronate, enhanced the killing of both HCC and CRC.""?",False, +9617771,Zoledronic acid disrupts bone fracture,1393,"If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.","Is the triple ""Zoledronic acid disrupts bone fracture"" supported by the sentence: ""If the increases in bone mineral density with zoledronate translate into reduced fractures, once-yearly intravenous zoledronate could be simple prophylaxis for postmenopausal osteoporosis.""?",False, +22662537,Zoledronic acid prevents osteoporosis,1394,"As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.","Is the triple ""Zoledronic acid prevents osteoporosis"" supported by the sentence: ""As Zol enjoys a considerable potential in treating and preventing osteoporosis, it can be used as one of the effective treatments in this field.""?",False, +20148397,Zoledronic acid prevents osteonecrosis,1395,Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.,"Is the triple ""Zoledronic acid prevents osteonecrosis"" supported by the sentence: ""Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function.""?",False, +13621414,Zoledronic acid prevents bone fracture,1396,"5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.","Is the triple ""Zoledronic acid prevents bone fracture"" supported by the sentence: ""5 mg-infusion of zoledronate in the 90 days following hip fracture, then annual, decreases new clinical fractures and improves survival.""?",False, +12127006,Zoledronic acid prevents Marchiafava-Bignami disease,1397,CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.,"Is the triple ""Zoledronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSIONS AND CLINICAL RELEVANCE: Zoledronate may reduce subchondral bone loss and effect markers of bone metabolism in dogs with experimentally induced instability of the stifle joint and subsequent development of osteoarthritis.""?",False, +20851623,Zoledronic acid predisposes bone fracture,1398,"A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.","Is the triple ""Zoledronic acid predisposes bone fracture"" supported by the sentence: ""A cost utility analysis from the health care system perspective compared alendronate, etidronate, risedronate, zoledronate, denosumab, and no pharmacotherapy using a Markov model incorporating data on fracture risk and their associated costs, mortality, and disutility and treatment effect.""?",False, +15272127,Zoledronic acid predisposes osteonecrosis,1399,"Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.","Is the triple ""Zoledronic acid predisposes osteonecrosis"" supported by the sentence: ""Also the potency of N-BPs might be different, suggesting a greater risk of osteonecrosis of the jaw with zoledronate.""?",False, +14006582,Risedronic acid prevents osteoporosis,1400,"A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.","Is the triple ""Risedronic acid prevents osteoporosis"" supported by the sentence: ""A 77-year-old man, treated with risedronic acid to prevent corticosteroid-induced osteoporosis, was admitted to hospital with acute abdominal pain.""?",False, +17290459,IBANDRONIC ACID affects osteonecrosis,1401,"Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.","Is the triple ""IBANDRONIC ACID affects osteonecrosis"" supported by the sentence: ""Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial.""?",False, +9797983,IBANDRONIC ACID affects Neoplasm Metastasis,1402,Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.,"Is the triple ""IBANDRONIC ACID affects Neoplasm Metastasis"" supported by the sentence: ""Here we specifically studied the effects of the BP ibandronate on visceral metastases of breast cancer using two animal models.""?",False, +15290649,IBANDRONIC ACID prevents bone disorder,1403,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""IBANDRONIC ACID prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, +13697992,IBANDRONIC ACID prevents Pain,1404,"Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.","Is the triple ""IBANDRONIC ACID prevents Pain"" supported by the sentence: ""Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.""?",False, +10307139,IBANDRONIC ACID prevents postmenopausal osteoporosis,1405,"OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.","Is the triple ""IBANDRONIC ACID prevents postmenopausal osteoporosis"" supported by the sentence: ""OBJECTIVES: To investigate the efficacy, safety, and dose-response of once-weekly oral ibandronate in the prevention of postmenopausal bone loss.""?",False, +10028971,IBANDRONIC ACID prevents osteoporosis,1406,These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.,"Is the triple ""IBANDRONIC ACID prevents osteoporosis"" supported by the sentence: ""These data support the potential for the long-term administration of ibandronate by intermittent iv bolus injections in humans to prevent osteoporosis and improve bone quality at clinically relevant sites.""?",False, +18363632,IBANDRONIC ACID predisposes Abdominal pain,1407,"The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.","Is the triple ""IBANDRONIC ACID predisposes Abdominal pain"" supported by the sentence: ""The incidence of diarrhoea, nausea and adverse renal events was similar between the ibandronate and placebo groups, but ibandronate was associated with greater risk of abdominal pain.""?",False, +9434475,IBANDRONIC ACID predisposes osteoporosis,1408,The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.,"Is the triple ""IBANDRONIC ACID predisposes osteoporosis"" supported by the sentence: ""The study showed that 2.5 mg ibandronate per day was efficient for prevention of bone loss and increment in bone mass in a population of women at particular risk of osteoporosis because of low bone mass.""?",False, +17514758,Alendronic acid related to osteoarthritis,1409,OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.,"Is the triple ""Alendronic acid related to osteoarthritis"" supported by the sentence: ""OBJECTIVES: The aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee.""?",False, +14283477,Alendronic acid related to osteoporosis,1410,"To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.","Is the triple ""Alendronic acid related to osteoporosis"" supported by the sentence: ""To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO.""?",False, +11575454,Alendronic acid related to postmenopausal osteoporosis,1411,Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.,"Is the triple ""Alendronic acid related to postmenopausal osteoporosis"" supported by the sentence: ""Comparison of zinc excretion and biochemical markers of bone remodelling in the assessment of the effects of alendronate and calcitonin on bone in postmenopausal osteoporosis.""?",False, +14254304,Alendronic acid causes asthma,1412,Alendronate-induced asthma.,"Is the triple ""Alendronic acid causes asthma"" supported by the sentence: ""Alendronate-induced asthma.""?",False, +14049757,Alendronic acid causes osteoporosis,1413,The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.,"Is the triple ""Alendronic acid causes osteoporosis"" supported by the sentence: ""The in-vitro bone-repairing efficacy of PLGA/HA-AL system was first tested with macrophages that are identified as precursors of osteoclasts and potentially responsible for osteoporosis.""?",False, +11710947,Alendronic acid causes Marchiafava-Bignami disease,1414,Alendronate as an effective countermeasure to disuse induced bone loss.,"Is the triple ""Alendronic acid causes Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate as an effective countermeasure to disuse induced bone loss.""?",False, +25124892,Alendronic acid affects Marchiafava-Bignami disease,1415,"EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.","Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""EXPERT OPINION: Compared to antiresorptive (AR) agents, its unique mechanism of action results in a quicker and greater increase in low bone mineral density, it repairs and restores trabecular and cortical bone microarchitecture, and reduces fracture risk more rapidly and more effectively than the AR alendronate, with persisting effects for at least two years after transition to ARs.""?",False, +24296937,Alendronic acid affects bone disorder,1416,The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.,"Is the triple ""Alendronic acid affects bone disorder"" supported by the sentence: ""The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.""?",False, +17701514,Alendronic acid affects osteoarthritis,1417,This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.,"Is the triple ""Alendronic acid affects osteoarthritis"" supported by the sentence: ""This study investigated the effects of pre-emptive use of ALN on OA related osteoclastic subchondral bone resorption in an in vivo rat model for severe OA.""?",False, +14769549,Alendronic acid affects postmenopausal osteoporosis,1418,The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.,"Is the triple ""Alendronic acid affects postmenopausal osteoporosis"" supported by the sentence: ""The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.""?",False, +12316243,Alendronic acid affects osteoporosis,1419,"Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.","Is the triple ""Alendronic acid affects osteoporosis"" supported by the sentence: ""Furthermore, the effects of alendronate on osteoporosis have been histologically evaluated.""?",False, +12136907,Alendronic acid affects periodontitis,1420,We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.,"Is the triple ""Alendronic acid affects periodontitis"" supported by the sentence: ""We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis.""?",False, +8809813,Alendronic acid affects Marchiafava-Bignami disease,1421,We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.,"Is the triple ""Alendronic acid affects Marchiafava-Bignami disease"" supported by the sentence: ""We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.""?",False, +22627610,Alendronic acid disrupts aortic valve stenosis,1422,Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.,"Is the triple ""Alendronic acid disrupts aortic valve stenosis"" supported by the sentence: ""Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study.""?",False, +17047070,Alendronic acid disrupts prostate cancer,1423,"For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).","Is the triple ""Alendronic acid disrupts prostate cancer"" supported by the sentence: ""For alendronate, reduced risk associations were found for prostate cancer in the QResearch (OR: 0.81, 95% CI: 0.70-0.93) and combined (OR: 0.84, 95% CI: 0.75-0.93) analyses (trend with duration P-values 0.009 and 0.001).""?",False, +9109277,Alendronic acid disrupts Marchiafava-Bignami disease,1424,"Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.","Is the triple ""Alendronic acid disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Also, the alendronate would seem to antagonise the osteopenia of L-thyroxine, though this mechanism is still unknown.""?",False, +8466156,Alendronic acid disrupts postmenopausal osteoporosis,1425,(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.,"Is the triple ""Alendronic acid disrupts postmenopausal osteoporosis"" supported by the sentence: ""(3) Three trials have shown that 5 mg/day alendronic acid slows postmenopausal bone loss.""?",False, +24628288,Alendronic acid prevents osteoarthritis,1426,"Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.","Is the triple ""Alendronic acid prevents osteoarthritis"" supported by the sentence: ""Therefore, we propose the use of alendronate as a disease modifying agent to help slow and prevent OA.""?",False, +15290647,Alendronic acid prevents bone disorder,1427,"Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.","Is the triple ""Alendronic acid prevents bone disorder"" supported by the sentence: ""Bisphosphonates [alendronate (ALD), ibandronate (IBD) and risedronate (RSD)] are potential candidates to prevent PHT-induced bone disorders, and the present study evaluated their effect on the antiepileptic efficacy of PHT.""?",False, +7495571,Alendronic acid prevents osteoporosis,1428,"Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.","Is the triple ""Alendronic acid prevents osteoporosis"" supported by the sentence: ""Alendronate (alendronic acid; 4-amino-1-hydroxybutylidene bisphosphonate) has demonstrated effectiveness orally in the treatment and prevention of postmenopausal osteoporosis, corticosteroid-induced osteoporosis and Paget's disease of the bone.""?",False, +7314446,Alendronic acid prevents Marchiafava-Bignami disease,1429,Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.,"Is the triple ""Alendronic acid prevents Marchiafava-Bignami disease"" supported by the sentence: ""Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture.""?",False, +7150371,Alendronic acid prevents postmenopausal osteoporosis,1430,Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).,"Is the triple ""Alendronic acid prevents postmenopausal osteoporosis"" supported by the sentence: ""Data from the Danish cohort (n = 67) of a multicenter trial of oral alendronate in the prevention of postmenopausal osteoporosis were used to evaluate the capacity of the biochemical markers to predict changes in bone mineral density (BMD).""?",False, +25381093,Alendronic acid predisposes osteoporosis,1431,"In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.","Is the triple ""Alendronic acid predisposes osteoporosis"" supported by the sentence: ""In this study we aim to investigate the combined effects of quercetin and alendronate on the markers of osteoporosis, autophagy, and apoptosis in the bone of ovariectomized rats.""?",False, +22975353,Alendronic acid predisposes Marchiafava-Bignami disease,1432,We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.,"Is the triple ""Alendronic acid predisposes Marchiafava-Bignami disease"" supported by the sentence: ""We investigated if BTM measured before or during treatment discontinuation with ALN predict bone loss after 1 or 2 years.""?",False, +12652815,Pamidronic acid related to osteoporosis,1433,The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.,"Is the triple ""Pamidronic acid related to osteoporosis"" supported by the sentence: ""The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.""?",False, +7541169,Pamidronic acid related to plasma cell myeloma,1434,Effect of calcitriol and pamidronate in multiple myeloma.,"Is the triple ""Pamidronic acid related to plasma cell myeloma"" supported by the sentence: ""Effect of calcitriol and pamidronate in multiple myeloma.""?",False, +12040766,Pamidronic acid affects plasma cell myeloma,1435,"MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.","Is the triple ""Pamidronic acid affects plasma cell myeloma"" supported by the sentence: ""MATERIALS AND METHODS: We examined the antiproliferative effects of 1,24(OH)2D2 in combination with the bisphosphonate pamidronate on multiple myeloma (H929), prostate (LNCaP) and breast (MCF-7) cancer cell lines.""?",False, +10860757,Pamidronic acid affects osteoporosis,1436,The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.,"Is the triple ""Pamidronic acid affects osteoporosis"" supported by the sentence: ""The aim of this study was to evaluate the effect of pamidronate on the osteoporosis of thalassaemia.""?",False, +9170219,Pamidronic acid prevents osteoporosis,1437,Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.,"Is the triple ""Pamidronic acid prevents osteoporosis"" supported by the sentence: ""Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis.""?",False, +9315699,Octyl methoxycinnamate prevents sunburn,1438,"In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.","Is the triple ""Octyl methoxycinnamate prevents sunburn"" supported by the sentence: ""In this study in hairless mice, we compared two UVB absorbers, 2-ethylhexyl-p-methoxycinnamate (2-EHMC) and octyl-N-dimethyl-p-aminobenzoate (o-PABA), individually formulated in a common base lotion with a sunburn protection factor of 6.""?",False, +10529058,4-Aminobenzoic acid coexists with Procaine,1439,[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].,"Is the triple ""4-Aminobenzoic acid coexists with Procaine"" supported by the sentence: ""[Changes in nerve excitability & conductibility induced by novocaine combined with p-aminobenzoic acid (vitamin H1)].""?",False, +25771688,Nitrazepam causes epilepsy,1440,The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.,"Is the triple ""Nitrazepam causes epilepsy"" supported by the sentence: ""The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.""?",False, +19206956,Nitrazepam affects depressive disorder,1441,The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.,"Is the triple ""Nitrazepam affects depressive disorder"" supported by the sentence: ""The effect of nitrazepam on depression and curiosity in behavioral tests in mice: The role of potassium channels.""?",False, +25737609,Nitrazepam disrupts epilepsy,1442,"Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.","Is the triple ""Nitrazepam disrupts epilepsy"" supported by the sentence: ""Among the 5 anticonvulsants studied, phenobarbital (30 mg/kg) and nitrazepam (3 mg/kg) completely antagonized the seizures; carbamazepine showed a moderate effect; and phenytoin as well as sodium valproate showed little effect.""?",False, +7322742,Nitrazepam prevents epilepsy,1443,NZP was discontinued if there was < 50% seizure reduction or significant side effects.,"Is the triple ""Nitrazepam prevents epilepsy"" supported by the sentence: ""NZP was discontinued if there was < 50% seizure reduction or significant side effects.""?",False, +25779340,Flurazepam causes depressive disorder,1444,"Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.","Is the triple ""Flurazepam causes depressive disorder"" supported by the sentence: ""Large iontophoretic doses (5--30 nA, 0.1 M solution) of flurazepam induced a depression of spike amplitude.""?",False, +19092155,Triazolam causes depressive disorder,1445,"In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.","Is the triple ""Triazolam causes depressive disorder"" supported by the sentence: ""In some cases triazolam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.""?",False, +16852864,Triazolam causes insomnia,1446,"This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.","Is the triple ""Triazolam causes insomnia"" supported by the sentence: ""This study was undertaken to determine whether a single night's use of triazolam by normal healthy sleepers leads to withdrawal insomnia on the subsequent night, and whether there is a dose response relationship to this phenomenon.""?",False, +27224077,Triazolam affects insomnia,1447,OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).,"Is the triple ""Triazolam affects insomnia"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of triazolam upon insomnia and daytime sleepiness in patients with rheumatoid arthritis (RA).""?",False, +15159227,Triazolam disrupts anxiety,1448,Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.,"Is the triple ""Triazolam disrupts anxiety"" supported by the sentence: ""Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.""?",False, +24702695,Midazolam related to delirium,1449,"The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.","Is the triple ""Midazolam related to delirium"" supported by the sentence: ""The association of increased CCL2 levels with delirium remained robust in various models controlling for age, presence of shock, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation IV score, mean arterial pressure at presentation, lowest mean arterial pressure, and total opioid, midazolam, propofol, and dexmedetomidine exposure.""?",False, +16327495,Midazolam related to obesity disorder,1450,The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.,"Is the triple ""Midazolam related to obesity disorder"" supported by the sentence: ""The aim was to study how release of glucose and stress hormones are affected when procedural sedation with nitrous oxide or midazolam are used for establishing intravenous access in obese and lean children.""?",False, +17503618,Midazolam causes Nausea,1451,Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.,"Is the triple ""Midazolam causes Nausea"" supported by the sentence: ""Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children.""?",False, +13087342,Midazolam causes status epilepticus,1452,PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.,"Is the triple ""Midazolam causes status epilepticus"" supported by the sentence: ""PURPOSE: The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats.""?",False, +12880145,Midazolam causes delirium,1453,"Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.","Is the triple ""Midazolam causes delirium"" supported by the sentence: ""Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol.""?",False, +12134398,Midazolam causes brain injury,1454,"Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.","Is the triple ""Midazolam causes brain injury"" supported by the sentence: ""Nasal midazolam at 5 min prevented brain damage, while delaying the midazolam treatment to 30 min of EGSA resulted in brain damage.""?",False, +11162624,Midazolam causes Pain,1455,Sedation with midazolam leads to reduced pain after dental surgery.,"Is the triple ""Midazolam causes Pain"" supported by the sentence: ""Sedation with midazolam leads to reduced pain after dental surgery.""?",False, +10221339,Midazolam causes injury,1456,"CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.","Is the triple ""Midazolam causes injury"" supported by the sentence: ""CONCLUSION: Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.""?",False, +10197463,Midazolam causes epilepsy,1457,Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.,"Is the triple ""Midazolam causes epilepsy"" supported by the sentence: ""Midazolam causes seizure-like activity in very-low-birthweight premature infants requiring the drug prior to tracheal intubation or during prolonged positive pressure ventilation.""?",False, +7739374,Midazolam causes hypotensive disorder,1458,"For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.","Is the triple ""Midazolam causes hypotensive disorder"" supported by the sentence: ""For refractory GCSE, continuous i.v. midazolam infusion at 0.1-0.6 mg/kg/hr after a 0.2 mg/kg i.v. bolus is effective and has advantages over traditional therapies because it induces less hypotension and cardiorespiratory depression and can be easily titrated.""?",False, +7211473,Midazolam causes depressive disorder,1459,We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.,"Is the triple ""Midazolam causes depressive disorder"" supported by the sentence: ""We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.""?",False, +7104276,Midazolam causes dissociative amnesia,1460,"In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.","Is the triple ""Midazolam causes dissociative amnesia"" supported by the sentence: ""In 30 patients (ASA-1) for elective Cesarean section who had given informed consent, characteristics of amnesia induced by midazolam (M) and their modulation by flumazenil (F) were examined.""?",False, +27271852,Midazolam affects Pruritus,1461,"In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.","Is the triple ""Midazolam affects Pruritus"" supported by the sentence: ""In outpatients receiving a combination of midazolam and remifentanil during local anesthesia, the level of sedation appears to influence the incidence of both intraoperative pruritus and PONV.""?",False, +26121850,Midazolam affects Pain,1462,"Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.","Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam is superior to diazepam in increasing sedation, and decreasing pain and procedure recall.""?",False, +25522494,Midazolam affects anxiety,1463,"Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""Midazolam, generally used as an anxiolytic, might impact distinctively on pain depending on anxiety.""?",False, +22514965,Midazolam affects anxiety,1464,"A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.","Is the triple ""Midazolam affects anxiety"" supported by the sentence: ""A randomized controlled clinical trial.OBJECTIVES: This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.""?",False, +22203290,Midazolam affects post-traumatic stress disorder,1465,The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.,"Is the triple ""Midazolam affects post-traumatic stress disorder"" supported by the sentence: ""The study also attempted to determine whether environmental enrichment altered the effects of midazolam on these PTSD-like behaviors.""?",False, +21411467,Midazolam affects Suicidal ideation,1466,"Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).","Is the triple ""Midazolam affects Suicidal ideation"" supported by the sentence: ""Linear mixed models revealed that compared with midazolam, a single ketamine infusion elicited larger reduction in SI (P = 0.01), with maximal effects measured at 7 days postinfusion (P < 0.001, Cohen's d = 0.83).""?",False, +20820424,Midazolam affects injury,1467,"Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.","Is the triple ""Midazolam affects injury"" supported by the sentence: ""Midazolam has been reported to have inhibitory effects on activated immunity and escalated inflammation, however, what the effects of midazolam on the liver injury caused by excessive immuno-inflammatory response in sepsis, and what influence it will exert on inflamed liver macrophages need to be elucidated.""?",False, +20230773,Midazolam affects hypotensive disorder,1468,Sudden hypotension associated with midazolam and sufentanil.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""Sudden hypotension associated with midazolam and sufentanil.""?",False, +19683992,Midazolam affects injury,1469,Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.,"Is the triple ""Midazolam affects injury"" supported by the sentence: ""Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.""?",False, +18986257,Midazolam affects neoplasm,1470,Studies have also shown that midazolam has an anticancer effect on various tumors.,"Is the triple ""Midazolam affects neoplasm"" supported by the sentence: ""Studies have also shown that midazolam has an anticancer effect on various tumors.""?",False, +18893940,Midazolam affects hypertensive disorder,1471,"Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.","Is the triple ""Midazolam affects hypertensive disorder"" supported by the sentence: ""Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.""?",False, +18670184,Midazolam affects hypotensive disorder,1472,"According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.","Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""According to the further analysis, the combination of Shenfu injection and Propofol + Fentany + Midazolam may reduce the incidence of hypotension and bradycardia during anesthesia, accelerate recovery after anesthesia and relieve the synergistic effect after anesthesia.""?",False, +18644607,Midazolam affects neuralgia,1473,Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.,"Is the triple ""Midazolam affects neuralgia"" supported by the sentence: ""Intrathecal midazolam has been proved to have its role in relieving neuropathic pain.""?",False, +18331473,Midazolam affects status epilepticus,1474,"The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.","Is the triple ""Midazolam affects status epilepticus"" supported by the sentence: ""The activity of SPD and VCD against SE is superior to that of diazepam and midazolam in terms of rapid onset, potency, and ability to block SE when given 20 to 60 min after seizure onset. sec-Butylpropylacetamide and VCD possess two stereogenic carbons in their chemical structure and, thus, exist as a racemic mixture of four individual stereoisomers.""?",False, +17655582,Midazolam affects Cough,1475,Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.,"Is the triple ""Midazolam affects Cough"" supported by the sentence: ""Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.""?",False, +12605496,Midazolam affects dissociative amnesia,1476,Midazolam tends to have more favorable effects on amnesia.,"Is the triple ""Midazolam affects dissociative amnesia"" supported by the sentence: ""Midazolam tends to have more favorable effects on amnesia.""?",False, +12154940,Midazolam affects Nausea,1477,"We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.","Is the triple ""Midazolam affects Nausea"" supported by the sentence: ""We compared the effects of clonidine and those of midazolam on postoperative shivering, nausea and vomiting in elderly patients.""?",False, +11981571,Midazolam affects delirium,1478,The development of delirium was associated with the medication midazolam taken perioperatively.,"Is the triple ""Midazolam affects delirium"" supported by the sentence: ""The development of delirium was associated with the medication midazolam taken perioperatively.""?",False, +8867560,Midazolam affects Pain,1479,Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.,"Is the triple ""Midazolam affects Pain"" supported by the sentence: ""Midazolam for the treatment of phantom limb pain exacerbation: preliminary reports.""?",False, +8871799,Midazolam affects hypotensive disorder,1480,The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.,"Is the triple ""Midazolam affects hypotensive disorder"" supported by the sentence: ""The use of midazolam for prehospital rapid-sequence intubation may be associated with a dose-related increase in hypotension.""?",False, +8701804,Midazolam affects epilepsy,1481,Nasal midazolam effects on childhood acute seizures.,"Is the triple ""Midazolam affects epilepsy"" supported by the sentence: ""Nasal midazolam effects on childhood acute seizures.""?",False, +8569605,Midazolam affects brain injury,1482,"Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.","Is the triple ""Midazolam affects brain injury"" supported by the sentence: ""Significantly fewer rats in the N(2)O/Naloxone, Phenytoin, and Midazolam Groups sustained any brain damage compared with controls.""?",False, +7116661,Midazolam affects Postoperative Nausea and Vomiting,1483,The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.,"Is the triple ""Midazolam affects Postoperative Nausea and Vomiting"" supported by the sentence: ""The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study.""?",False, +20025306,Midazolam disrupts Pruritus,1484,"Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.","Is the triple ""Midazolam disrupts Pruritus"" supported by the sentence: ""Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus.""?",False, +18424847,Midazolam disrupts status epilepticus,1485,"Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.","Is the triple ""Midazolam disrupts status epilepticus"" supported by the sentence: ""Midazolam successfully stopped 306/339 SE episodes (90.3%), 67 SE (21.9%) by equal or lower dose than 0.2 mg/kg as the first line drug, while all other 239 episodes (78.9%) were stopped by intravenous infusion in range 0.2-1.2 mg/kg/h (mean 0.4 mg/kg/h) as the third line drug.""?",False, +16150704,Midazolam disrupts Cough,1486,CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.,"Is the triple ""Midazolam disrupts Cough"" supported by the sentence: ""CONCLUSIONS: Pretreatment with dexmedetomidine-midazolam could completely suppress FIC caused by fentanyl 3 MUg/kg injection within 2 s.""?",False, +14733481,Midazolam disrupts neuralgia,1487,Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.,"Is the triple ""Midazolam disrupts neuralgia"" supported by the sentence: ""Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.""?",False, +13861580,Midazolam disrupts Pain,1488,"CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.","Is the triple ""Midazolam disrupts Pain"" supported by the sentence: ""CONCLUSIONS: We conclude that when intraarticular midazolam was compared with placebo there was a reduction in pain after day-case arthroscopic knee surgery; however, this pain relief was of relatively short duration.""?",False, +9443524,Midazolam disrupts epilepsy,1489,"PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.","Is the triple ""Midazolam disrupts epilepsy"" supported by the sentence: ""PTB was usually titrated to EEG background suppression by using intermittent EEG monitoring, whereas MDL and PRO were more often titrated to seizure suppression with continuous EEG monitoring.""?",False, +7819099,Midazolam disrupts anxiety,1490,CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.,"Is the triple ""Midazolam disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians.""?",False, +21663738,Midazolam prevents anxiety,1491,This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.,"Is the triple ""Midazolam prevents anxiety"" supported by the sentence: ""This study was performed to elucidate whether intravenous midazolam with maternal presence is more efficient than intravenous midazolam alone in the reduction of pain and anxiety of lumbar puncture (LP) in 6 to 24-month-old children.""?",False, +20820423,Midazolam prevents injury,1492,Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.,"Is the triple ""Midazolam prevents injury"" supported by the sentence: ""Results: Midazolam prevented liver tissue injury and decreased serum alanine transaminase (ALT) level in LPS plus galactosamine treated mice.""?",False, +17322994,Midazolam prevents Aggressive behavior,1493,"Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.","Is the triple ""Midazolam prevents Aggressive behavior"" supported by the sentence: ""Conversely, treatment with a non-sedative acute dose of midazolam in dominants reduced aggressive behaviour and increased sexual behaviour, whereas in subordinates no behavioural changes were noted.""?",False, +16397367,Midazolam prevents status epilepticus,1494,"Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.","Is the triple ""Midazolam prevents status epilepticus"" supported by the sentence: ""Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus.""?",False, +13467675,Midazolam prevents Nausea,1495,Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.,"Is the triple ""Midazolam prevents Nausea"" supported by the sentence: ""Subhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.""?",False, +11373548,Midazolam prevents Cough,1496,"CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.","Is the triple ""Midazolam prevents Cough"" supported by the sentence: ""CONCLUSION: The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed.""?",False, +11041799,Midazolam prevents bone fracture,1497,"Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.","Is the triple ""Midazolam prevents bone fracture"" supported by the sentence: ""Alternatively, induction of deep sedation with analgesic agents such as ketamine or fentanyl, often combined with sedative-anxiolytic agents such as midazolam, may be used to manage distress associated with fracture reduction.""?",False, +9493413,Midazolam prevents epilepsy,1498,"Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.","Is the triple ""Midazolam prevents epilepsy"" supported by the sentence: ""Initially intravenous midazolam (0.5 mg/kg/hour) slightly decreased the seizures, although oral vitamin B6, valproic acid, clonazepam, and zonisamide had little effect.""?",False, +8653279,Midazolam prevents Sepsis,1499,"Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.","Is the triple ""Midazolam prevents Sepsis"" supported by the sentence: ""Because neutrophils are the most important effector cells for protecting against sepsis, and propofol and midazolam are the most widely used anesthetics for sedation, we studied the effects of these two anesthetics on the neutrophil function during sepsis.""?",False, +8569600,Midazolam prevents brain injury,1500,"Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.","Is the triple ""Midazolam prevents brain injury"" supported by the sentence: ""Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats.""?",False, +8151023,Midazolam prevents Pain,1501,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Midazolam prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, +7116663,Midazolam prevents Postoperative Nausea and Vomiting,1502,We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.,"Is the triple ""Midazolam prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.""?",False, +16657523,Midazolam exacerbates Sepsis,1503,"METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.","Is the triple ""Midazolam exacerbates Sepsis"" supported by the sentence: ""METHODS: observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done.""?",False, +19191198,Midazolam predisposes dissociative amnesia,1504,This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.,"Is the triple ""Midazolam predisposes dissociative amnesia"" supported by the sentence: ""This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration.""?",False, +18422952,Midazolam predisposes status epilepticus,1505,"Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.","Is the triple ""Midazolam predisposes status epilepticus"" supported by the sentence: ""Relative efficacies of CLZ, LZP, and MDZ were compared by assessing the risk of developing refractory SE and the number of antiseizure drugs (ASDs) required to control SE.""?",False, +11981572,Midazolam predisposes delirium,1506,The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.,"Is the triple ""Midazolam predisposes delirium"" supported by the sentence: ""The use of midazolam in the perioperative period increased the risk of developing postoperative delirium.""?",False, +22402246,Brotizolam disrupts anxiety,1507,"Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.","Is the triple ""Brotizolam disrupts anxiety"" supported by the sentence: ""Brotizolam is an effective hypnotic for hospital patients awaiting surgery, in whom it also reduces anxiety.""?",False, +12312025,Ganirelix related to polycystic ovary syndrome,1508,LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.,"Is the triple ""Ganirelix related to polycystic ovary syndrome"" supported by the sentence: ""LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.""?",False, +14831488,Cetrorelix disrupts benign prostatic hyperplasia,1509,Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.,"Is the triple ""Cetrorelix disrupts benign prostatic hyperplasia"" supported by the sentence: ""Mechanisms of inhibition of human benign prostatic hyperplasia in vitro by the luteinizing hormone-releasing hormone antagonist cetrorelix.""?",False, +18703871,Cetrorelix prevents endometriosis,1510,"CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.","Is the triple ""Cetrorelix prevents endometriosis"" supported by the sentence: ""CONCLUSION(S): JNKI alone was as effective as JNKI + MPA or cetrorelix in reducing induced endometriosis in baboons, but without severe side effects or effect on cycle length or serum reproductive hormones.""?",False, +18874469,Methoxsalen related to Deoxyribonucleic acid,1511,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, +18874469,Methoxsalen related to Deoxyribonucleic acid,1512,A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-MOP and DNA was made.""?",False, +12069194,Methoxsalen related to mycosis fungoides,1513,Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.,"Is the triple ""Methoxsalen related to mycosis fungoides"" supported by the sentence: ""Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.""?",False, +8610329,Methoxsalen related to psoriasis,1514,"Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.","Is the triple ""Methoxsalen related to psoriasis"" supported by the sentence: ""Narrowband UVB radiation (311-313 nm) is used successfully as monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption.""?",False, +26218137,Methoxsalen related to Deoxyribonucleic acid,1515,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, +26218137,Methoxsalen related to Deoxyribonucleic acid,1516,The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.,"Is the triple ""Methoxsalen related to Deoxyribonucleic acid"" supported by the sentence: ""The data also suggest the methyl ester of DMeCP to be an interesting nonphotosensitizing furocoumarin that photoconjugates to DNA better than 8-MOP and is therapeutically effective in psoriasis.""?",False, +7172075,Methoxsalen coexists with Deoxyribonucleic acid,1517,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, +7172075,Methoxsalen coexists with Deoxyribonucleic acid,1518,An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.,"Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""An increased (up to 50%) efficiency of SOS-repair of monoadducts of 8-methoxypsoralen in DNA of pBR322 and lambda in the presence of plasmid pKM101 muc+ (incN) was found.""?",False, +26761340,Methoxsalen coexists with Deoxyribonucleic acid,1519,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, +26761340,Methoxsalen coexists with Deoxyribonucleic acid,1520,"The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.","Is the triple ""Methoxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which the 8-MOP is covalently bound to two pyrimidines from complementary strands.""?",False, +7782040,Methoxsalen physically interacts with Deoxyribonucleic acid,1521,"New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.","Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.""?",False, +12022213,Methoxsalen physically interacts with Deoxyribonucleic acid,1522,MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.,"Is the triple ""Methoxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""MATERIALS AND METHODS: The improved method described here was formulated after studying the exact molecular mechanism of action of 8-MOP with DNA.""?",False, +9512596,Methoxsalen affects Deoxyribonucleic acid,1523,"Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produced S-phase apoptosis in WRN-deficient LCLs.""?",False, +19709381,Methoxsalen affects Deoxyribonucleic acid,1524,"Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.","Is the triple ""Methoxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP.""?",False, +8674128,Trioxsalen coexists with Deoxyribonucleic acid,1525,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, +8674128,Trioxsalen coexists with Deoxyribonucleic acid,1526,When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.,"Is the triple ""Trioxsalen coexists with Deoxyribonucleic acid"" supported by the sentence: ""When cells are irradiated in the frozen state the number of 4'-aminomethyl trioxsalen molecules bound per 10(3) base pairs in DNA is about 40 and in RNA about 20.""?",False, +8674127,Trioxsalen physically interacts with Deoxyribonucleic acid,1527,"In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.","Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In Drosophila cells and HeLa cells treated with 4'-aminomethyl trioxsalen and ultraviolet light, this compound binds covalently to DNA and RNA.""?",False, +25732039,Trioxsalen physically interacts with Deoxyribonucleic acid,1528,The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.,"Is the triple ""Trioxsalen physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA in both embryo nuclei and tissue culture cells from Drosophila melanogaster was found to be about 90% protected from trioxsalen binding relative to purified DNA.""?",False, +16826513,Trioxsalen affects Deoxyribonucleic acid,1529,"Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.","Is the triple ""Trioxsalen affects Deoxyribonucleic acid"" supported by the sentence: ""Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.""?",False, +9717834,Bisoprolol related to hypertensive disorder,1530,"Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.","Is the triple ""Bisoprolol related to hypertensive disorder"" supported by the sentence: ""Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.""?",False, +17484309,Bisoprolol affects Hemorrhage,1531,CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.,"Is the triple ""Bisoprolol affects Hemorrhage"" supported by the sentence: ""CONCLUSION: This clinical trial has demonstrated that administration of a single pre-operative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.""?",False, +14633716,Bisoprolol affects hypertensive disorder,1532,CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.,"Is the triple ""Bisoprolol affects hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Bisoprolol and perindopril effectively reduced elevated blood pressure.""?",False, +13150765,Bisoprolol affects pulmonary arterial hypertension,1533,"MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.","Is the triple ""Bisoprolol affects pulmonary arterial hypertension"" supported by the sentence: ""MATERIAL AND METHODS: Effects of an 8-week course of bisoprolol therapy on pulmonary hypertension, its efficacy and safety were studied in 30 IHD patients with COPD of stage III-IV on broncholytic therapy.""?",False, +24626572,Bisoprolol disrupts Hemorrhage,1534,No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.,"Is the triple ""Bisoprolol disrupts Hemorrhage"" supported by the sentence: ""No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality.""?",False, +23315135,Bisoprolol prevents Hemorrhage,1535,"Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).","Is the triple ""Bisoprolol prevents Hemorrhage"" supported by the sentence: ""Several antihypertensive drugs, such as amlodipine and bisoprolol, were associated with a decreased risk of bleeding (warfarin + amlodipine [aOR, 0.64; 95% confidence interval (CI): 0.41-0.98], DOACs + bisoprolol [aOR, 0.51; 95% CI, 0.33-0.80]).""?",False, +26817035,Esmolol related to atrial fibrillation,1536,"In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.","Is the triple ""Esmolol related to atrial fibrillation"" supported by the sentence: ""In conclusion, simultaneous use of digoxin and esmolol is effective in safely and rapidly controlling heart rate in atrial fibrillation or flutter.""?",False, +13689489,Esmolol causes atrial fibrillation,1537,Esmolol or atropine markedly increased the threshold for AF induction.,"Is the triple ""Esmolol causes atrial fibrillation"" supported by the sentence: ""Esmolol or atropine markedly increased the threshold for AF induction.""?",False, +20072391,Esmolol affects toxic shock syndrome,1538,The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.,"Is the triple ""Esmolol affects toxic shock syndrome"" supported by the sentence: ""The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.""?",False, +19519833,Esmolol affects Pain,1539,"Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.","Is the triple ""Esmolol affects Pain"" supported by the sentence: ""Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.""?",False, +16877299,Esmolol prevents Pain,1540,Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.,"Is the triple ""Esmolol prevents Pain"" supported by the sentence: ""Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.""?",False, +10180097,Esmolol prevents ischemia reperfusion injury,1541,"Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.","Is the triple ""Esmolol prevents ischemia reperfusion injury"" supported by the sentence: ""Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts.""?",False, +9581320,Esmolol prevents atrial fibrillation,1542,We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.,"Is the triple ""Esmolol prevents atrial fibrillation"" supported by the sentence: ""We performed a pilot study of the efficacy of early intravenous esmolol and an oral beta-blocker regimen for prevention of postoperative AF.""?",False, +18235527,Oxygen related to pulmonary fibrosis,1543,"However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.","Is the triple ""Oxygen related to pulmonary fibrosis"" supported by the sentence: ""However, current data suggest that the production of oxygen radicals by way of a ferrous ion-molecular oxygen mechanism might be related to the pulmonary fibrosis.""?",False, +18193743,Oxygen related to neoplasm,1544,Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.,"Is the triple ""Oxygen related to neoplasm"" supported by the sentence: ""Scintillating nanoparticles (NPs) in combination with X-ray or gamma-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect.""?",False, +17303485,Oxygen related to Hypoxemia,1545,"CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.","Is the triple ""Oxygen related to Hypoxemia"" supported by the sentence: ""CONCLUSION: The observation of activity in hypoxia suggests that there exists an oxygen-independent, Type I photoprocess for this new class of compounds in addition to the typical Type II pathway mediated by singlet oxygen.""?",False, +14116536,Oxygen related to Shock,1546,The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.,"Is the triple ""Oxygen related to Shock"" supported by the sentence: ""The chemiluminescence from the singlet oxygen was emitted in the collapse of the interface due to molecular diffusion under laminar flow conditions.""?",False, +13587155,Oxygen related to injury,1547,These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.,"Is the triple ""Oxygen related to injury"" supported by the sentence: ""These results demonstrate that heme oxygenase can be activated by non-metalloporphyrins as well as by photosensitization associated with singlet oxygen mediated subcellular injury.""?",False, +8813011,Oxygen related to ischemia reperfusion injury,1548,Cardiac toxicity of singlet oxygen: implication in reperfusion injury.,"Is the triple ""Oxygen related to ischemia reperfusion injury"" supported by the sentence: ""Cardiac toxicity of singlet oxygen: implication in reperfusion injury.""?",False, +21893162,Oxygen causes neoplasm,1549,"Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.","Is the triple ""Oxygen causes neoplasm"" supported by the sentence: ""Viapi-pi stacking interactions, the MWCNTs enable highly efficient loading of ICG and the ICG-loaded MWCNTs exhibit excellent photostability and can be used for FL imaging/PDT of tumors due to the singlet oxygen ( 1 O 2 ) generation from ICG.""?",False, +19992109,Oxygen causes ischemia reperfusion injury,1550,The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.,"Is the triple ""Oxygen causes ischemia reperfusion injury"" supported by the sentence: ""The purpose of this study was to test the hypothesis that molecular oxygen must be provided at reperfusion to produce I/R injury in skeletal muscle.""?",False, +8243272,Oxygen causes vascular disorder,1551,"Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.","Is the triple ""Oxygen causes vascular disorder"" supported by the sentence: ""Superoxide, the reduced form of molecular oxygen, has been implicated in the genesis of vascular disease.""?",False, +8114891,Oxygen causes injury,1552,New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.,"Is the triple ""Oxygen causes injury"" supported by the sentence: ""New studies indicate that the intraoperative reintroduction of molecular oxygen on cardiopulmonary bypass causes a reoxygenation injury leading to postoperative cardiac dysfunction.""?",False, +7992845,Oxygen causes Hypoxemia,1553,"At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.","Is the triple ""Oxygen causes Hypoxemia"" supported by the sentence: ""At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness.""?",False, +7752235,Oxygen causes stroke disorder,1554,We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.,"Is the triple ""Oxygen causes stroke disorder"" supported by the sentence: ""We evaluated the in vivo antioxidant activity of genistein in a mouse model of singlet oxygen-induced cerebral stroke.""?",False, +23272853,Oxygen affects neoplasm,1555,"The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""The ultrasmall 3-5 nm nano-Pt enables better penetration in tumors, which is also facilitated by the generated oxygen gas, for enhanced chemotherapy.""?",False, +22206348,Oxygen affects neoplasm,1556,"Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.","Is the triple ""Oxygen affects neoplasm"" supported by the sentence: ""Moreover, in vivo high-frequency ultrasound and thermal imaging were used to evaluate the oxygen-production capacity and photothermal conversion effect of MnO 2 -ICG@BSA at the tumor site, and Singlet Oxygen Sensor Green (SOSG) was used to measure singlet oxygen levels in the tumor.""?",False, +19397332,Oxygen affects Hypoxemia,1557,"Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.","Is the triple ""Oxygen affects Hypoxemia"" supported by the sentence: ""Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized.""?",False, +13060611,Oxygen affects Shock,1558,Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.,"Is the triple ""Oxygen affects Shock"" supported by the sentence: ""Cellular growth kinetics and rates of [3H]thymidine incorporation showed that both transfectants were more resistant to oxidative shocks mediated by cumene hydroperoxide or singlet oxygen generated by photosensitized rose bengal than were T47D cells and control transfectants.""?",False, +13638133,Oxygen produces Hypoxemia,1559,"However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.","Is the triple ""Oxygen produces Hypoxemia"" supported by the sentence: ""However, the efficacy of one-photon (1-gamma) PDT is limited by hypoxia, which can prevent the production of the cytotoxic singlet oxygen ((1)O(2)) species, leading to tumor resistance to PDT.""?",False, +13264427,Oxygen produces neoplasm,1560,"The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.","Is the triple ""Oxygen produces neoplasm"" supported by the sentence: ""The use of lasers, over the past few decades, has emerged to be highly promising for cancer therapy modalities, most commonly the photothermal therapy method, which employs light absorbing dyes for achieving the photothermal damage of tumors, and the photodynamic therapy, which employs chemical photosensitizers that generate singlet oxygen that is capable of tumor destruction.""?",False, +12483211,Oxygen disrupts Hypoxemia,1561,Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.,"Is the triple ""Oxygen disrupts Hypoxemia"" supported by the sentence: ""Since the HIF hydroxylases have an absolute requirement for molecular oxygen this process is suppressed in hypoxia allowing the HIF-alpha to escape destruction and activate transcription.""?",False, +11682185,Oxygen disrupts neoplasm,1562,"While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.","Is the triple ""Oxygen disrupts neoplasm"" supported by the sentence: ""While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as PhiDelta is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.""?",False, +16806319,Oxygen prevents injury,1563,"Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.","Is the triple ""Oxygen prevents injury"" supported by the sentence: ""Self-assembling, concentrated, lipid-based oxygen microparticles (LOMs) have been developed to administer oxygen gas when injected intravenously, preventing organ injury and death from systemic hypoxemia in animal models.""?",False, +17280500,Oxygen predisposes injury,1564,"Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.","Is the triple ""Oxygen predisposes injury"" supported by the sentence: ""Eosin, a xanthene dye capable of the photodynamic generation of singlet oxygen ((1)O2), was shown to promote injury to leaf tissue of Pisum sativum L. in the presence of visible light.""?",False, +7575686,Metoprolol subclass of O-Demethylmetoprolol,1565,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of O-Demethylmetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, +7575685,Metoprolol subclass of alpha-Hydroxymetoprolol,1566,"The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.","Is the triple ""Metoprolol subclass of alpha-Hydroxymetoprolol"" supported by the sentence: ""The observed Km and Vmax, and the formation kinetics of alpha-hydroxymetoprolol and O-demethylmetoprolol, two major metoprolol metabolites, were in keeping with published data.""?",False, +27359356,Metoprolol related to alpha-Hydroxymetoprolol,1567,"When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.","Is the triple ""Metoprolol related to alpha-Hydroxymetoprolol"" supported by the sentence: ""When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR.""?",False, +27639377,Metoprolol derives from alpha-Hydroxymetoprolol,1568,"METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.","Is the triple ""Metoprolol derives from alpha-Hydroxymetoprolol"" supported by the sentence: ""METHODS: Using microsomes from two human livers, biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) as a function of the concentrations of the SSRIs and of some of their metabolites was studied.""?",False, +26548288,Metoprolol physically interacts with O-Demethylmetoprolol,1569,"Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.","Is the triple ""Metoprolol physically interacts with O-Demethylmetoprolol"" supported by the sentence: ""Although the favored regiomer overall was O-demethylmetoprolol, the regioselectivity for O-demethylation of metoprolol by the cDNA-expressed enzyme was several-fold less than that observed for the P4502D6 enzyme in human liver microsomes at 20 microM pseudoracematic metoprolol concentration.""?",False, +21656554,Metoprolol physically interacts with alpha-Hydroxymetoprolol,1570,Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.,"Is the triple ""Metoprolol physically interacts with alpha-Hydroxymetoprolol"" supported by the sentence: ""Simultaneous determination of metoprolol and alpha-hydroxymetoprolol in human plasma and urine by liquid chromatography with a preliminary observation on metoprolol oxidation in Japanese subjects.""?",False, +27101524,Metoprolol causes ventricular tachycardia,1571,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular tachycardia"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, +27101519,Metoprolol causes ventricular fibrillation,1572,"The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.","Is the triple ""Metoprolol causes ventricular fibrillation"" supported by the sentence: ""The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation.""?",False, +20648435,Metoprolol causes cardiac rhythm disease,1573,"Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.","Is the triple ""Metoprolol causes cardiac rhythm disease"" supported by the sentence: ""Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias.""?",False, +14625318,Metoprolol causes hypertensive disorder,1574,[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].,"Is the triple ""Metoprolol causes hypertensive disorder"" supported by the sentence: ""[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].""?",False, +19013861,Metoprolol affects obesity disorder,1575,"Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.","Is the triple ""Metoprolol affects obesity disorder"" supported by the sentence: ""Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol.""?",False, +17630974,Metoprolol affects coronary artery disorder,1576,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects coronary artery disorder"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, +17630973,Metoprolol affects atherosclerosis,1577,"Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.","Is the triple ""Metoprolol affects atherosclerosis"" supported by the sentence: ""Metoprolol has been and is still subject to intensive research, which has resulted in evidence for its cardiovascular protective effects in coronary heart disease, cardiovascular hypertrophy and atherosclerosis.""?",False, +16547648,Metoprolol affects myocardial infarction,1578,Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.,"Is the triple ""Metoprolol affects myocardial infarction"" supported by the sentence: ""Metoprolol can inhibit the expression of c-fos and has a positive therapeutic effect on rats after AMI; the involvement effect of metoprolol on myocardial infarction might be correlated with its effect on the inhibition of c-fos.""?",False, +12751741,Metoprolol affects cardiac rhythm disease,1579,"Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.","Is the triple ""Metoprolol affects cardiac rhythm disease"" supported by the sentence: ""Moreover, water-soluble beta-blockers such as atenolol and metoprolol are dialyzable and require supplementation to avoid exacerbation of arrhythmias following dialysis.""?",False, +11341339,Metoprolol affects hypertensive disorder,1580,The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).,"Is the triple ""Metoprolol affects hypertensive disorder"" supported by the sentence: ""The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in experimental hypertension induced by abdominal aortic coarctation (ACo).""?",False, +16802112,Metoprolol disrupts atrial fibrillation,1581,CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.,"Is the triple ""Metoprolol disrupts atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: (1) Perioperative metoprolol but not amiodarone itself in combination with metoprolol is associated with a significant reduction in postoperative AF.""?",False, +14314818,Metoprolol disrupts atherosclerosis,1582,"These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.","Is the triple ""Metoprolol disrupts atherosclerosis"" supported by the sentence: ""These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.""?",False, +13648308,Metoprolol disrupts ventricular tachycardia,1583,Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.,"Is the triple ""Metoprolol disrupts ventricular tachycardia"" supported by the sentence: ""Intravenous metoprolol effectively suppressed ventricular ectopy and AVNRT did not recur.""?",False, +12510783,Metoprolol disrupts cardiac rhythm disease,1584,"However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.","Is the triple ""Metoprolol disrupts cardiac rhythm disease"" supported by the sentence: ""However, 1-metoprolol completely inhibited the occurrence of arrhythmias induced by ritodrine and phenylephrine.""?",False, +16624344,Metoprolol prevents cardiac rhythm disease,1585,Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.,"Is the triple ""Metoprolol prevents cardiac rhythm disease"" supported by the sentence: ""Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation.""?",False, +13530896,Metoprolol prevents myocardial infarction,1586,"POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.","Is the triple ""Metoprolol prevents myocardial infarction"" supported by the sentence: ""POISE suggests that initiating metoprolol therapy shortly prior to non-cardiac surgery increases the risk of hypotension, stroke and death, despite reducing the risk of myocardial infarction.""?",False, +13366014,Metoprolol prevents hypertensive disorder,1587,Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.,"Is the triple ""Metoprolol prevents hypertensive disorder"" supported by the sentence: ""Metoprolol and atenolol effectively prevented the development of hypertension in diabetic rats.""?",False, +13268090,Metoprolol prevents ventricular fibrillation,1588,"CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.","Is the triple ""Metoprolol prevents ventricular fibrillation"" supported by the sentence: ""CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.""?",False, +9428080,Metoprolol prevents atrial fibrillation,1589,Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.,"Is the triple ""Metoprolol prevents atrial fibrillation"" supported by the sentence: ""Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation.""?",False, +7236533,Metoprolol prevents atherosclerosis,1590,"The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.","Is the triple ""Metoprolol prevents atherosclerosis"" supported by the sentence: ""The analysis was based on the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study, a randomised trial which showed a significantly lower risk for coronary events in patients taking metoprolol than in patients on thiazide diuretics.""?",False, +22663349,Metoprolol predisposes atrial fibrillation,1591,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Metoprolol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, +25990864,Acebutolol affects hypertensive disorder,1592,The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.,"Is the triple ""Acebutolol affects hypertensive disorder"" supported by the sentence: ""The possibility that acebutolol and other beta-blockers might accelerate BP elevation and incidence of stroke must be reexamined.""?",False, +25995365,Acebutolol prevents hypertensive disorder,1593,"Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.","Is the triple ""Acebutolol prevents hypertensive disorder"" supported by the sentence: ""Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment.""?",False, +24856753,Pretomanid affects multidrug-resistant tuberculosis,1594,"Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.","Is the triple ""Pretomanid affects multidrug-resistant tuberculosis"" supported by the sentence: ""Our objective is to evaluate the effectiveness, safety and tolerability of various doses and duration of linezolid (LZD) in combination with bedaquiline (BDQ) and pretomanid (Pa) after 26 weeks of treatment in adults with pre-extensively drug-resistant or treatment intolerant/non-responsive multidrug-resistant pulmonary TB.""?",False, +17848125,Nitrogen related to chronic obstructive pulmonary disease,1595,"Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.","Is the triple ""Nitrogen related to chronic obstructive pulmonary disease"" supported by the sentence: ""Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD.""?",False, +15192685,Nitrogen related to ischemia reperfusion injury,1596,"Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.","Is the triple ""Nitrogen related to ischemia reperfusion injury"" supported by the sentence: ""Our knowledge on the role of mitochondria in generating reactive oxygen and nitrogen species, in contributing to ionic disturbances, and in initiating the mitochondrial permeability transition with subsequent cellular death in liver IR injury is continuously being expanded.""?",False, +10505101,Nitrogen related to burn,1597,The effect on the nitrogen metabolism of severely burned patients.,"Is the triple ""Nitrogen related to burn"" supported by the sentence: ""The effect on the nitrogen metabolism of severely burned patients.""?",False, +10425490,Nitrogen related to cystic fibrosis,1598,Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.,"Is the triple ""Nitrogen related to cystic fibrosis"" supported by the sentence: ""Amino-acid nitrogen of the blood in fibrocystic disease of the pancreas.""?",False, +16934805,Nitrogen causes ischemia reperfusion injury,1599,"METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.","Is the triple ""Nitrogen causes ischemia reperfusion injury"" supported by the sentence: ""METHODS: Mice were exposed for 2 h to either 70% xenon, or 70% nitrogen, 24 h before the induction of renal ischemia-reperfusion injury.""?",False, +13030867,Nitrogen affects ischemia reperfusion injury,1600,Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.,"Is the triple ""Nitrogen affects ischemia reperfusion injury"" supported by the sentence: ""Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury.""?",False, +9020164,Nitrogen affects severe acute respiratory syndrome,1601,"The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.","Is the triple ""Nitrogen affects severe acute respiratory syndrome"" supported by the sentence: ""The SAR optimization of the 1,4-benzodiazepine scaffold has included variations at the 5-, 7-, 8-position, at the N1, N-indole nitrogen and the configuration of the C3-position.""?",False, +17493096,Nitrogen predisposes ischemia reperfusion injury,1602,BACKGROUND: Nitrogen may contribute to reperfusion injury.,"Is the triple ""Nitrogen predisposes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Nitrogen may contribute to reperfusion injury.""?",False, +25313239,Helium related to status asthmaticus,1603,[Use of helium and oxygen mixtures in status asthmaticus].,"Is the triple ""Helium related to status asthmaticus"" supported by the sentence: ""[Use of helium and oxygen mixtures in status asthmaticus].""?",False, +12274245,Helium related to chronic obstructive pulmonary disease,1604,The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.,"Is the triple ""Helium related to chronic obstructive pulmonary disease"" supported by the sentence: ""The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.""?",False, +15248421,Carbon Dioxide related to Pain,1605,"Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.","Is the triple ""Carbon Dioxide related to Pain"" supported by the sentence: ""Breathing retraining improved ETCO2, pain and function in all patients with 93% achieving at least a clinically important change in either pain or function.""?",False, +11844945,Carbon Dioxide related to sleep apnea syndrome,1606,"Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.","Is the triple ""Carbon Dioxide related to sleep apnea syndrome"" supported by the sentence: ""Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients.""?",False, +10575797,Carbon Dioxide related to respiratory failure,1607,Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.,"Is the triple ""Carbon Dioxide related to respiratory failure"" supported by the sentence: ""Use of venous blood for pH and carbon-dioxide studies especially in respiratory failure and during anaesthesia.""?",False, +7620110,Carbon Dioxide related to panic disorder,1608,To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.,"Is the triple ""Carbon Dioxide related to panic disorder"" supported by the sentence: ""To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder.""?",False, +16671036,Carbon Dioxide causes panic disorder,1609,"We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.","Is the triple ""Carbon Dioxide causes panic disorder"" supported by the sentence: ""We also discuss a regimen for safely tapered withdrawal of clonazepam, the characteristics of the respiratory subtype of PD, and CO2-induced panic attacks as a diagnostic measure and predictor for therapeutic success.""?",False, +11038318,Carbon Dioxide causes respiratory failure,1610,"BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.","Is the triple ""Carbon Dioxide causes respiratory failure"" supported by the sentence: ""BACKGROUND: High calorie intakes, especially as carbohydrate, increase carbon dioxide production (VCO2) and may precipitate respiratory failure in patients with severe pulmonary disease.""?",False, +20071308,Carbon Dioxide affects Pain,1611,"INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.","Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""INTRODUCTION: Residual, intra-abdominal CO2 contributes to abdominal distension and pain after laparoscopic surgery.""?",False, +15771768,Carbon Dioxide affects Pain,1612,Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.,"Is the triple ""Carbon Dioxide affects Pain"" supported by the sentence: ""Multiple RCT support an effect of carbon dioxide in reducing pain after colonoscopy.""?",False, +15385933,Carbon Dioxide affects panic disorder,1613,"In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.","Is the triple ""Carbon Dioxide affects panic disorder"" supported by the sentence: ""In 712 general population twins we analyzed by Maximum Likelihood analyses of ordinal data whether life (major- and stressful) events moderate the genetic risk for PD and CO2 sensitivity, as indexed by the 35% CO2 /65% O2 challenge.""?",False, +14460813,Carbon Dioxide affects respiratory failure,1614,"Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.","Is the triple ""Carbon Dioxide affects respiratory failure"" supported by the sentence: ""Congenital central hypoventilation syndrome (CCHS) is accompanied by reduced ventilatory sensitivity to CO2 and O2, respiratory drive failure during sleep, impaired autonomic, fluid, and food absorption regulation, and affective and cognitive deficits, including memory deficiencies.""?",False, +15294247,Carbon Dioxide produces respiratory failure,1615,"As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.","Is the triple ""Carbon Dioxide produces respiratory failure"" supported by the sentence: ""As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits.""?",False, +11946282,Carbon Dioxide disrupts Pain,1616,BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.,"Is the triple ""Carbon Dioxide disrupts Pain"" supported by the sentence: ""BACKGROUND AND STUDY AIMS: Several studies have shown that insufflation of carbon dioxide (CO2) instead of air during colonoscopy can reduce postprocedural pain.""?",False, +17126447,Carbon Dioxide predisposes Pain,1617,OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.,"Is the triple ""Carbon Dioxide predisposes Pain"" supported by the sentence: ""OBJECTIVE: Residual carbon dioxide contributes substantially to pain following laparoscopic surgery.""?",False, +11404382,Carbon Dioxide predisposes panic disorder,1618,"Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.","Is the triple ""Carbon Dioxide predisposes panic disorder"" supported by the sentence: ""Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical ""bedside"" predictive test for panic disorder after a first attack.""?",False, +7432027,Carbon Dioxide predisposes respiratory failure,1619,"At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.","Is the triple ""Carbon Dioxide predisposes respiratory failure"" supported by the sentence: ""At the beginning of the process there is hypocarbia, but when the attack progresses muscle fatigue happens, and retention of CO2, being a sing of alarm (predictive of respiratory failure) a normal and rising PaCO2.""?",False, +24776228,Ethambutol causes tuberculosis,1620,From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.,"Is the triple ""Ethambutol causes tuberculosis"" supported by the sentence: ""From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India.""?",False, +25946331,Ethambutol affects tuberculosis,1621,Effects of ethambutol on tuberculous diseases of the eye.,"Is the triple ""Ethambutol affects tuberculosis"" supported by the sentence: ""Effects of ethambutol on tuberculous diseases of the eye.""?",False, +24875144,Ethambutol affects pulmonary tuberculosis,1622,Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).,"Is the triple ""Ethambutol affects pulmonary tuberculosis"" supported by the sentence: ""Colivelin weakened the alleviation effect of EMB on PTB (all P <0.001).""?",False, +25597027,Ethambutol disrupts tuberculosis,1623,Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.,"Is the triple ""Ethambutol disrupts tuberculosis"" supported by the sentence: ""Recommendation of Pharmacokinetics/Pharmacodynamics Target of Ethambutol to Suppress Tuberculosis Resistance: A Population Pharmacokinetics Study on Large Prospective Cohort.""?",False, +18704735,Ethambutol prevents tuberculosis,1624,"After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.","Is the triple ""Ethambutol prevents tuberculosis"" supported by the sentence: ""After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis.""?",False, +14472959,Pyrazinamide affects pulmonary tuberculosis,1625,Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.,"Is the triple ""Pyrazinamide affects pulmonary tuberculosis"" supported by the sentence: ""Effect of vitamin D on efficacy of pyrazinamide in pulmonary tuberculosis.""?",False, +10149898,Pyrazinamide affects tuberculosis,1626,Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.,"Is the triple ""Pyrazinamide affects tuberculosis"" supported by the sentence: ""Pyrazinamide (PZA) is an important sterilising tuberculosis drug that helps to shorten the duration of current chemotherapy regimens for tuberculosis.""?",False, +8080030,Pyrazinamide prevents tuberculosis,1627,Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.,"Is the triple ""Pyrazinamide prevents tuberculosis"" supported by the sentence: ""Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial.""?",False, +27556045,Pyrazinamide predisposes tuberculosis,1628,"The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.","Is the triple ""Pyrazinamide predisposes tuberculosis"" supported by the sentence: ""The Kaplan-Meier estimate of the risk of tuberculosis during the first 10 months after entry was 3.7% among participants who received rifampicin and pyrazinamide compared with 1.0% (p=0.03) among participants who received isoniazid, and 5.4% versus 5.1%, respectively (p=0.9) at 36 months after entry.""?",False, +26376727,Androstanolone related to hypogonadism,1629,"The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.","Is the triple ""Androstanolone related to hypogonadism"" supported by the sentence: ""The particularities of percutaneous absorption of a natural androgen, 5 alpha-dihydrotestosterone, were evaluated in substitutive androgen therapy in masculine hypogonadism.""?",False, +22807780,Androstanolone affects hypogonadism,1630,"In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.","Is the triple ""Androstanolone affects hypogonadism"" supported by the sentence: ""In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT) and estradiol, in the regulation of depot-specific adipose tissue mass.""?",False, +7261548,Nebivolol related to essential hypertension,1631,Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.,"Is the triple ""Nebivolol related to essential hypertension"" supported by the sentence: ""Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.""?",False, +10251853,Nebivolol affects hypertensive disorder,1632,In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.,"Is the triple ""Nebivolol affects hypertensive disorder"" supported by the sentence: ""In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis.""?",False, +20026875,Nebivolol prevents cardiovascular disorder,1633,Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.,"Is the triple ""Nebivolol prevents cardiovascular disorder"" supported by the sentence: ""Nebivolol (NEB) in contrast to atenolol (ATE) may have a beneficial effect on endothelial function and may be more effective than ATE in preventing CVD.""?",False, +10251855,Nebivolol prevents hypertensive disorder,1634,These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.,"Is the triple ""Nebivolol prevents hypertensive disorder"" supported by the sentence: ""These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.""?",False, +11558481,Nebivolol exacerbates hypertensive disorder,1635,"Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.","Is the triple ""Nebivolol exacerbates hypertensive disorder"" supported by the sentence: ""Similarly, the favourable haemodynamic profile of nebivolol, as described by the new investigations (preservation of cardiac output, reduction of peripheral resistance and improved diastolic function) appear to have clinically relevant benefits on the impairment in systolic and/or diastolic function often complicating the hypertension.""?",False, +17527026,Landiolol related to atrial fibrillation,1636,INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.,"Is the triple ""Landiolol related to atrial fibrillation"" supported by the sentence: ""INTRODUCTION: Results from the multicenter trial (J-Land study) of landiolol versus digoxin in atrial fibrillation (AF) and atrial flutter (AFL) patients with left ventricular (LV) dysfunction revealed that landiolol was more effective for controlling rapid HR than digoxin.""?",False, +14267268,Landiolol affects atrial fibrillation,1637,The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.,"Is the triple ""Landiolol affects atrial fibrillation"" supported by the sentence: ""The purpose of this study was to investigate the prophylactic effect of continuous administration of low-dose landiolol on postoperative atrial fibrillation.""?",False, +16074351,Landiolol disrupts atrial fibrillation,1638,"RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).","Is the triple ""Landiolol disrupts atrial fibrillation"" supported by the sentence: ""RESULTS: Postoperative atrial fibrillation occurred in 4 (11.1%) of the 36 patients in the landiolol group, compared with 11 (32.3%) of the 34 patients in the control group, indicating that development of atrial fibrillation was significantly inhibited by landiolol (P=0.042).""?",False, +21882778,Landiolol prevents cardiac rhythm disease,1639,INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.,"Is the triple ""Landiolol prevents cardiac rhythm disease"" supported by the sentence: ""INTERPRETATION: Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia.""?",False, +14873276,Landiolol prevents atrial fibrillation,1640,"Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.","Is the triple ""Landiolol prevents atrial fibrillation"" supported by the sentence: ""Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable.""?",False, +20190145,Landiolol predisposes atrial fibrillation,1641,"In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.","Is the triple ""Landiolol predisposes atrial fibrillation"" supported by the sentence: ""In patients with landiolol, risk factors for POAF were age, arch aneurysm, and timing of landiolol administration.""?",False, +26530979,Oxandrolone related to nutritional disorder,1642,"For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.","Is the triple ""Oxandrolone related to nutritional disorder"" supported by the sentence: ""For prednisolone, the response was seen only when the DF was 81-100 reducing mortality 45% When oxandrolone, an androgenic anabolic steroid treatment was given, efficacy was observed only in those with moderate malnutrition (PCM score 60-79% of normal) and maximized with adequate caloric intake reducing mortality 86%.""?",False, +17138340,Oxandrolone related to Fanconi anemia,1643,"CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.","Is the triple ""Oxandrolone related to Fanconi anemia"" supported by the sentence: ""CONCLUSION: Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA.""?",False, +12117784,Oxandrolone related to Turner syndrome,1644,"Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.","Is the triple ""Oxandrolone related to Turner syndrome"" supported by the sentence: ""Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.""?",False, +11269262,Oxandrolone related to burn,1645,The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.,"Is the triple ""Oxandrolone related to burn"" supported by the sentence: ""The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns.""?",False, +7561027,Cefepime causes toxic shock syndrome,1646,"Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.","Is the triple ""Cefepime causes toxic shock syndrome"" supported by the sentence: ""Some antibiotics such as carbapenems, ceftriaxone, cefepime, glycopeptides, aminoglycosides and quinolones do not have the propensity to provoke septic shock because their rapid bactericidal activity induces mainly spheroplast or fragile spheroplast-like bacterial forms.""?",False, +19437692,Cefepime affects bacterial infectious disease,1647,"OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.","Is the triple ""Cefepime affects bacterial infectious disease"" supported by the sentence: ""OBJECTIVES: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it.""?",False, +17947468,Cefepime affects infectious disease,1648,"CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.","Is the triple ""Cefepime affects infectious disease"" supported by the sentence: ""CONCLUSION: Major topics explored in the top-ranked ID articles of 2013 include the use of cefepime for gram-negative infections due to AmpC or extended-spectrum beta-lactamase-producing Enterobacteriaceae, optimizing antibiotic therapy through the use of extended- or continuous-infusion regimens, the use of the oral integrase inhibitor dolutegravir to combat HIV disease, and new approaches to treatment of Clostridium difficile infection and enterococcal endocarditis.""?",False, +19800344,Cefepime disrupts infectious disease,1649,"CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.","Is the triple ""Cefepime disrupts infectious disease"" supported by the sentence: ""CONCLUSIONS: Cefepime demonstrated increased mortality compared with carbapenems, reduced efficacy in clinically documented infections, and higher rates of toxicity-related treatment discontinuation.""?",False, +26336145,"Hydrocortisone butyrate related to dermatitis, atopic",1650,[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].,"Is the triple ""Hydrocortisone butyrate related to dermatitis, atopic"" supported by the sentence: ""[Hydrocortisone-17-butyrate (0.1 percent) versus hydrocortisone acetate (1 percent) in atopic dermatitis. Controlled double-blind study of 20 children].""?",False, +26243703,Hydrocortisone butyrate related to skin disorder,1651,[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].,"Is the triple ""Hydrocortisone butyrate related to skin disorder"" supported by the sentence: ""[Effectiveness of fusidic acid alone and in combination with hydrocortisone-17-butyrate in infected dermatoses].""?",False, +25968096,Hydrocortisone butyrate related to psoriasis,1652,Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.,"Is the triple ""Hydrocortisone butyrate related to psoriasis"" supported by the sentence: ""Comparison of desoximetasone and hydrocortisone butyrate in psoriasis.""?",False, +17603464,Hydrocortisone butyrate disrupts psoriasis,1653,"Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.","Is the triple ""Hydrocortisone butyrate disrupts psoriasis"" supported by the sentence: ""Compared to PBS-treated psoriatic animals, treatment with anti-FGF10, like hydrocortisone butyrate, greatly inhibited the severity of psoriasis-like lesions by reducing the Baker's scores, the thickness of epidermis, and the numbers of monocyte infiltrates in the dermis of animals.""?",False, +9729745,Adapalene related to acne,1654,The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.,"Is the triple ""Adapalene related to acne"" supported by the sentence: ""The topical retinoid tretinoin and topical retinoid analogues such as adapalene and tazarotene help normalize hyperkeratinization in acne vulgaris and have demonstrated significant anti-inflammatory effects in experimental trials.""?",False, +8571018,Adapalene physically interacts with Retinoic Acid Receptor,1655,Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.,"Is the triple ""Adapalene physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis.""?",False, +13523825,Retinol related to eye disorder,1656,"A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.","Is the triple ""Retinol related to eye disorder"" supported by the sentence: ""A REPORT ON THE USE OF VITAMIN ""A"" IN CONJUNCTION WITH ULTRA-VIOLET LIGHT IN OPHTHALMIC DISEASES.""?",False, +11015290,Retinol related to tuberculosis,1657,[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].,"Is the triple ""Retinol related to tuberculosis"" supported by the sentence: ""[Pathogenesis of hypovitaminosis A in tuberculosis; the effect of lipotropic substances on the vitamin A and carotene blood levels in tuberculosis].""?",False, +10457909,Retinol related to acne,1658,Vitamin A in acne vulgaris.,"Is the triple ""Retinol related to acne"" supported by the sentence: ""Vitamin A in acne vulgaris.""?",False, +8518043,Retinol related to malaria,1659,Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.,"Is the triple ""Retinol related to malaria"" supported by the sentence: ""Pharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.""?",False, +8137103,Retinol related to vitamin A deficiency,1660,"CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.","Is the triple ""Retinol related to vitamin A deficiency"" supported by the sentence: ""CONCLUSIONS: Vitamin A deficiency inhibits the adaptive response to partial small bowel resection, supporting a role for vitamin A in the adaptive process.""?",False, +7807614,Retinol related to retinitis pigmentosa,1661,"Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.","Is the triple ""Retinol related to retinitis pigmentosa"" supported by the sentence: ""Disturbed utilization of vitamin A also appears to play a part in retinitis pigmentosa, and a subgroup of patients benefit from supplementation.""?",False, +9304322,Retinol causes malaria,1662,"Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).","Is the triple ""Retinol causes malaria"" supported by the sentence: ""Children who were <12 months of age and had malaria at enrollment experienced a 747-g (95% CI: 71-1423) higher yearly weight gain attributable to vitamin A; among children without malaria, however, the supplements did not have a significant effect (-57 g; 95% CI: -461-348).""?",False, +27090494,Retinol affects diarrheal disease,1663,"However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.","Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""However, we found a significant interaction between supplementation and age: vitamin A increased the incidence of diarrhea in children < 30 mo of age, but tended to reduce the incidence in older children.""?",False, +21959378,Retinol affects nutritional disorder,1664,Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.,"Is the triple ""Retinol affects nutritional disorder"" supported by the sentence: ""Post-mortem concentrations of hepatic retinol and retinyl esters were determined in 40 subjects aged over 65 years to assess the effects of disease and malnutrition on vitamin A reserves.""?",False, +17401879,Retinol affects tuberculosis,1665,"Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.","Is the triple ""Retinol affects tuberculosis"" supported by the sentence: ""Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis.""?",False, +17082512,Retinol affects acne,1666,"Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.","Is the triple ""Retinol affects acne"" supported by the sentence: ""Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne.""?",False, +12962972,Retinol affects eye disorder,1667,"The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.","Is the triple ""Retinol affects eye disorder"" supported by the sentence: ""The addition of vitamin A to the diet increased the frequency of these eye abnormalities in all strains, suggesting that this effect is not mediated by loci associated with H-2, as is the case with vitamin A-enhanced cleft palate.""?",False, +12534891,Retinol affects vitamin A deficiency,1668,The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.,"Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied.""?",False, +11508263,Retinol affects diarrheal disease,1669,OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.,"Is the triple ""Retinol affects diarrheal disease"" supported by the sentence: ""OBJECTIVE: Our goal was to assess whether zinc added to iron treatment alone or with vitamin A improves iron indexes and affects diarrheal episodes.""?",False, +10941106,Retinol affects vitamin A deficiency,1670,"Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.","Is the triple ""Retinol affects vitamin A deficiency"" supported by the sentence: ""Additionally, an RA-inducible cytochrome P450, P450RAI or CYP26, is down-regulated in liver during vitamin A deficiency and up-regulated dose-dependently by dietary vitamin A and exogenous RA.""?",False, +22325993,Retinol produces Infection,1671,"As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).","Is the triple ""Retinol produces Infection"" supported by the sentence: ""As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP).""?",False, +23772860,Retinol disrupts vitamin A deficiency,1672,"Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.","Is the triple ""Retinol disrupts vitamin A deficiency"" supported by the sentence: ""Large-scale food fortification of vegetable oils with vitamin A has been implemented successfully for decades in numerous African and Asian countries, contributing demonstrably to reductions in vitamin A deficiency.""?",False, +12105339,Retinol disrupts diarrheal disease,1673,"Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.","Is the triple ""Retinol disrupts diarrheal disease"" supported by the sentence: ""Vitamin A alone reduced all-cause mortality and improved growth in a small sub-group of HIV-infected children in one hospital-based trial, and reduced diarrhoea-associated morbidity in a small HIV-infected sub-group of infants in another trial.""?",False, +24823924,Retinol prevents Infection,1674,Vitamin A protects against infections and maintains epithelial integrity.,"Is the triple ""Retinol prevents Infection"" supported by the sentence: ""Vitamin A protects against infections and maintains epithelial integrity.""?",False, +17332605,Retinol prevents malaria,1675,CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.,"Is the triple ""Retinol prevents malaria"" supported by the sentence: ""CONCLUSIONS: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.""?",False, +11445573,Retinol prevents nutritional disorder,1676,"Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.","Is the triple ""Retinol prevents nutritional disorder"" supported by the sentence: ""Regardless of the amount of vitamin A-rich foods consumed, children who were regularly supplemented with high doses of vitamin A were protected against malnutrition, diarrhea, and acute respiratory infection at a higher rate than children who were supplemented only once or were never supplemented.""?",False, +8153477,Retinol prevents diarrheal disease,1677,"BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.","Is the triple ""Retinol prevents diarrheal disease"" supported by the sentence: ""BACKGROUND: Vitamin A has well-recognized benefits for prevention of diarrhea, but the impact of therapeutic doses given during diarrhea on biochemical and clinical outcomes is less clear.""?",False, +23860384,Retinol predisposes nutritional disorder,1678,"The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.","Is the triple ""Retinol predisposes nutritional disorder"" supported by the sentence: ""The 2 cases and the subsequent discussion of vitamin A, B1, and B12 deficiencies underscore the value of taking a thorough dietary history and emphasize risk factors for these 3 nutritional deficiencies.""?",False, +19923430,Retinol predisposes malaria,1679,"We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.","Is the triple ""Retinol predisposes malaria"" supported by the sentence: ""We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: alpha-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II.""?",False, +16391363,Retinol predisposes tuberculosis,1680,"A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.","Is the triple ""Retinol predisposes tuberculosis"" supported by the sentence: ""A low serum albumin level also increased the risk of TB, but low vitamin A, thiamine, riboflavin, and iron status did not.""?",False, +15050082,Retinol predisposes diarrheal disease,1681,"Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.","Is the triple ""Retinol predisposes diarrheal disease"" supported by the sentence: ""Interventions including vitamin A, zinc and cotrimoxazole may contribute substantially to preventing diarrhoea in children with HIV infection or exposure to HIV.""?",False, +9744244,Retinol predisposes vitamin A deficiency,1682,"VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.","Is the triple ""Retinol predisposes vitamin A deficiency"" supported by the sentence: ""VA intake was assessed through 24 hour dietary recalls, risk of VA intake deficiency was assessed following the IVACG methodology, VA status was assessed through serum retinol levels (HPLCr) and Conjunctival Impression Cytology (CIC) according to ICEPO methodology.""?",False, +18962170,Isotretinoin related to neuroblastoma,1683,We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.,"Is the triple ""Isotretinoin related to neuroblastoma"" supported by the sentence: ""We also show marked synergy in tumor cell killing between MEK inhibitors (trametinib) and retinoids (isotretinoin) in primary nf1a-/- zebrafish neuroblastomas.""?",False, +16229483,Isotretinoin related to brain cancer,1684,"Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.","Is the triple ""Isotretinoin related to brain cancer"" supported by the sentence: ""Thus far, there are no established methods to quantify relevant retinoids (all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis retinoic acid, and retinol) in human brain tumors.""?",False, +15225681,Isotretinoin related to acne,1685,"The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.","Is the triple ""Isotretinoin related to acne"" supported by the sentence: ""The proliferation of isolated sebocytes is inhibited by retinoids, such as isotretinoin and tretinoin, which are known to be clinically active in human acne.""?",False, +14091563,Isotretinoin related to myelodysplastic syndrome,1686,Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.,"Is the triple ""Isotretinoin related to myelodysplastic syndrome"" supported by the sentence: ""Efficacy of a combination of human recombinant erythropoietin + 13-cis-retinoic acid and dihydroxylated vitamin D3 to improve moderate to severe anaemia in low/intermediate risk myelodysplastic syndromes.""?",False, +9061344,Isotretinoin related to renal cell carcinoma,1687,BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).,"Is the triple ""Isotretinoin related to renal cell carcinoma"" supported by the sentence: ""BACKGROUND: Interferon and 13-cis-retinoic acid (13-CRA) therapy showed clinical response rates of 30% in advanced renal cell carcinoma (RCC).""?",False, +11768316,Isotretinoin physically interacts with Retinoic Acid Receptor,1688,"The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.","Is the triple ""Isotretinoin physically interacts with Retinoic Acid Receptor"" supported by the sentence: ""The low binding affinity of 13-cis retinoic acid for retinoic acid receptors, low activity in gene expression assays and the accumulation of the all-trans isomer in cells treated with 13-cis retinoic acid, coupled with the more-favourable pharmacokinetic profile of 13-cis retinoic acid compared to other isomers, suggest that intracellular isomerisation to all-trans retinoic acid is the key process underlying the biological activity of 13-cis retinoic acid.""?",False, +21199868,Isotretinoin causes neuroblastoma,1689,"We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.","Is the triple ""Isotretinoin causes neuroblastoma"" supported by the sentence: ""We demonstrated that TERT expression is reduced during 13-cis retinoic acid-induced NB differentiation and that this inversely correlated with increased expression of AT-rich interaction domain 1A (ARID1A), a subunit of the SWItch/sucrose nonfermentable chromatin remodeling complex.""?",False, +19803622,Isotretinoin causes acne,1690,Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.,"Is the triple ""Isotretinoin causes acne"" supported by the sentence: ""Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics.""?",False, +19310397,Isotretinoin causes breast neoplasm,1691,Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.,"Is the triple ""Isotretinoin causes breast neoplasm"" supported by the sentence: ""Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells.""?",False, +13522698,Isotretinoin causes neoplasm,1692,"We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.","Is the triple ""Isotretinoin causes neoplasm"" supported by the sentence: ""We found that the combination of four HDIs (CI-994, MS-275, SAHA, and TSA) with retinoids all-trans-retinoic acid (ATRA) or 13-cis-retinoic acid (13-CRA) or our atypical retinoic acid metabolism blocking agents (RAMBAs) 1 (VN/14-1) or 2 (VN/66-1) produced synergistic anti-neoplastic activity on human LNCaP prostate cancer cells.""?",False, +23934527,Isotretinoin affects neoplasm,1693,"Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.""?",False, +20382078,Isotretinoin affects neuroblastoma,1694,"To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.","Is the triple ""Isotretinoin affects neuroblastoma"" supported by the sentence: ""To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid.""?",False, +15927367,Isotretinoin affects rosacea,1695,"Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.","Is the triple ""Isotretinoin affects rosacea"" supported by the sentence: ""Previously, the effect of isotretinoin in rosacea has been mainly studied in small cohorts or anecdotal reports.""?",False, +15330626,Isotretinoin affects acne,1696,"In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.","Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.""?",False, +11212975,Isotretinoin affects neoplasm,1697,"CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.","Is the triple ""Isotretinoin affects neoplasm"" supported by the sentence: ""CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective.""?",False, +9764204,Isotretinoin affects acne,1698,Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.,"Is the triple ""Isotretinoin affects acne"" supported by the sentence: ""Much has been learned of the pathogenesis of acne and the mechanism by which isotretinoin affects acne.""?",False, +21476432,Isotretinoin disrupts neuroblastoma,1699,Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.,"Is the triple ""Isotretinoin disrupts neuroblastoma"" supported by the sentence: ""Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.""?",False, +14724193,Isotretinoin disrupts neoplasm,1700,"Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.","Is the triple ""Isotretinoin disrupts neoplasm"" supported by the sentence: ""Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus.""?",False, +14863864,Isotretinoin prevents acne,1701,"The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.","Is the triple ""Isotretinoin prevents acne"" supported by the sentence: ""The therapeutic outcome of isotretinoin in treatment-resistant cases of acne in CGD patients has not been reported in the literature; we present this case to advocate an underreported use of isotretinoin in the prevention of acne, its subsequent cyst formation, and scarring patients with CGD.""?",False, +8312321,Isotretinoin prevents neoplasm,1702,Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.,"Is the triple ""Isotretinoin prevents neoplasm"" supported by the sentence: ""Muir-Torre syndrome - treatment with isotretinoin and interferon alpha-2a can prevent tumour development.""?",False, +15444114,Isotretinoin exacerbates ichthyosis,1703,We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.,"Is the triple ""Isotretinoin exacerbates ichthyosis"" supported by the sentence: ""We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis.""?",False, +15310461,Isotretinoin predisposes acne,1704,"OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.","Is the triple ""Isotretinoin predisposes acne"" supported by the sentence: ""OBJECTIVE: To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne.""?",False, +24593446,Trifarotene affects acne,1705,The current review evaluates the role of trifarotene in treating acne.,"Is the triple ""Trifarotene affects acne"" supported by the sentence: ""The current review evaluates the role of trifarotene in treating acne.""?",False, +21448312,Atazanavir affects AIDS,1706,Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?,"Is the triple ""Atazanavir affects AIDS"" supported by the sentence: ""Is the Risk of Myocardial Infarction in People With Human Immunodeficiency Virus (HIV) Associated With Atazanavir or Darunavir?""?",False, +24947472,Atazanavir disrupts HIV infectious disease,1707,"This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.","Is the triple ""Atazanavir disrupts HIV infectious disease"" supported by the sentence: ""This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration in plasma, brain, spleen, and lymphatics beneficial in the significant reduction of viral load in HIV infection.""?",False, +13198660,Atazanavir disrupts AIDS,1708,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Atazanavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, +20253995,Atazanavir prevents AIDS,1709,"Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.","Is the triple ""Atazanavir prevents AIDS"" supported by the sentence: ""Atazanavir is an antiretroviral medication used to treat and prevent HIV/AIDS, but its effects on cardiac fibrosis are unknown.""?",False, +8134603,Saquinavir affects HIV infectious disease,1710,The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.,"Is the triple ""Saquinavir affects HIV infectious disease"" supported by the sentence: ""The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.""?",False, +16320598,Saquinavir disrupts viral infectious disease,1711,"SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.","Is the triple ""Saquinavir disrupts viral infectious disease"" supported by the sentence: ""SQV also inhibited production of infectious virus in cervical, penile, and colorectal explants cocultured with T cells.""?",False, +13198658,Saquinavir disrupts AIDS,1712,Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.,"Is the triple ""Saquinavir disrupts AIDS"" supported by the sentence: ""Evidence of synergistic inhibition of wild-type HIV has been reported for saquinavir with atazanavir or lopinavir.""?",False, +17107608,Saquinavir prevents HIV infectious disease,1713,The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.,"Is the triple ""Saquinavir prevents HIV infectious disease"" supported by the sentence: ""The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV) to CD4(+) immune cells as a potential strategy to prevent or reduce HIV infection.""?",False, +12560548,Indinavir prevents viral infectious disease,1714,Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.,"Is the triple ""Indinavir prevents viral infectious disease"" supported by the sentence: ""Novel lipid associated drugs (i.e. indinavir) targeted to the lymphoid tissue have been shown to overcome limited drug exposure in the lymph nodes and to further reduce residual virus in tissue.""?",False, +15113750,Ritonavir related to AIDS,1715,Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.,"Is the triple ""Ritonavir related to AIDS"" supported by the sentence: ""Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient.""?",False, +7566746,Ritonavir related to Cytochrome P-450 CYP3A,1716,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, +7566746,Ritonavir related to Cytochrome P-450 CYP3A,1717,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir related to Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, +15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1718,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, +15583404,Ritonavir coexists with Cytochrome P-450 CYP3A,1719,"Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.","Is the triple ""Ritonavir coexists with Cytochrome P-450 CYP3A"" supported by the sentence: ""Using nonlinear mixed-effects modeling, we could separately quantify the effects of intestinal CYP3A4 expression, hepatic CYP3A4 expression, and the presence of ritonavir on both the absorption and elimination of lopinavir, which was previously not possible using noncompartmental methods.""?",False, +11500913,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1720,"In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""In this study, time- and concentration-dependent decreases in activity as defined by maximum rate of inactivation (k(inact)) and inhibitor concentration that gives 50% maximal inactivation (K(I)) of CYP3A by amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir were quantified using testosterone 6beta-hydroxylation as a marker for CYP3A activity with recombinant CYP3A4(+b(5)), recombinant CYP3A5, and pooled human liver microsomes (HLMs).""?",False, +8329957,Ritonavir physically interacts with Cytochrome P-450 CYP3A,1721,"Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.","Is the triple ""Ritonavir physically interacts with Cytochrome P-450 CYP3A"" supported by the sentence: ""Carbamazepine is metabolized in the liver to a large extent by the cytochrome P450 (CYP) system, especially CYP3A4, 2C8, and 1A2, whereas RTV is metabolized primarily by CYP3A and is a potent inhibitor of this enzyme.""?",False, +8452370,Ritonavir causes AIDS,1722,"Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.","Is the triple ""Ritonavir causes AIDS"" supported by the sentence: ""Acute hepatitis led to abnormal coagulopathy, bleeding, and death in a nonhemophiliac infant infected with the human immunodeficiency virus, possibly due to zidovudine or ritonavir or both.""?",False, +21492333,Ritonavir affects neoplasm,1723,Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.,"Is the triple ""Ritonavir affects neoplasm"" supported by the sentence: ""Anti-tumor experiments show that several PEG-RITs are much more active than unmodified RIT and the PEG location greatly affects anti-tumor activity.""?",False, +12140603,Ritonavir affects Insulin resistance,1724,"All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.","Is the triple ""Ritonavir affects Insulin resistance"" supported by the sentence: ""All together, these data show effects of ritonavir on human preadipocytes and adipocytes aiming at reducing adipose tissue mass and increasing insulin resistance.""?",False, +9520105,Ritonavir affects HIV infectious disease,1725,This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.,"Is the triple ""Ritonavir affects HIV infectious disease"" supported by the sentence: ""This lack of correlation between the 2 has led to the identification of additional effects of ritonavir that potentially alter HIV disease pathogenesis.""?",False, +7566745,Ritonavir affects Cytochrome P-450 CYP3A,1726,"The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""The ABT-378-ritonavir combinations (at 3:1 and 29:1 ratios) inhibited CYP3A (IC(50) = 1.1 and 4.6 microM), albeit less potently than ritonavir (IC(50) = 0.14 microM).""?",False, +15873481,Ritonavir affects Cytochrome P-450 CYP3A,1727,"As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.","Is the triple ""Ritonavir affects Cytochrome P-450 CYP3A"" supported by the sentence: ""As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ~2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ritonavir (RTV), and rifampin (RIF; induction positive control) on the cytochrome P450 enzymes CYP1A2, CYP2B6, CYP2C9, and CYP2D6 and the inductive or inductive plus inhibitory effect of NFV, RTV, or RIF on CYP3A and P-glycoprotein in healthy human volunteers.""?",False, +21820102,Ritonavir disrupts Coronavinae infectious disease,1728,"Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.","Is the triple ""Ritonavir disrupts Coronavinae infectious disease"" supported by the sentence: ""Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro.""?",False, +15656958,Ritonavir disrupts HIV infectious disease,1729,Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.,"Is the triple ""Ritonavir disrupts HIV infectious disease"" supported by the sentence: ""Certain ritonavir resistance mutations impair HIV infectivity through incomplete Gag processing by the mutant viral protease.""?",False, +9520113,Ritonavir disrupts neoplasm,1730,"In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.","Is the triple ""Ritonavir disrupts neoplasm"" supported by the sentence: ""In a KS mouse xenotransplantation model, ritonavir inhibited tumor formation and progression by KS-derived cells.""?",False, +22737012,Ritonavir prevents neoplasm,1731,"Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.","Is the triple ""Ritonavir prevents neoplasm"" supported by the sentence: ""Treatment with anti-PD-1 alone or low-dose 177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy.""?",False, +10934319,Ritonavir prevents Kaposi's sarcoma,1732,The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.,"Is the triple ""Ritonavir prevents Kaposi's sarcoma"" supported by the sentence: ""The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.""?",False, +12915909,Nelfinavir causes diarrheal disease,1733,Does Roche's nelfinavir cause less diarrhea?,"Is the triple ""Nelfinavir causes diarrheal disease"" supported by the sentence: ""Does Roche's nelfinavir cause less diarrhea?""?",False, +19184628,Nelfinavir affects neoplasm,1734,"Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.","Is the triple ""Nelfinavir affects neoplasm"" supported by the sentence: ""Moreover, nelfinavir-mediated anti-tumoral activity is severely compromised in eEF2K-deficient engrafted tumors in vivo Our findings imply that exacerbated activation of eEF2K is detrimental for tumor survival and describe a mechanism explaining the anti-tumoral properties of HIV-PIs.""?",False, +16087478,Nelfinavir affects plasma cell myeloma,1735,We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.,"Is the triple ""Nelfinavir affects plasma cell myeloma"" supported by the sentence: ""We assessed the in vitro and in vivo effects of nelfinavir on multiple myeloma.""?",False, +11272488,Nelfinavir affects diarrheal disease,1736,"The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.","Is the triple ""Nelfinavir affects diarrheal disease"" supported by the sentence: ""The diarrhea associated with lopinavir-ritonavir was less frequent, less severe, and shorter in duration than diarrhea associated with nelfinavir.""?",False, +10940786,Thiopental affects brain injury,1737,"Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.","Is the triple ""Thiopental affects brain injury"" supported by the sentence: ""Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.""?",False, +7790675,Thiopental prevents brain injury,1738,"BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.","Is the triple ""Thiopental prevents brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects.""?",False, +26262897,Pentobarbital causes insomnia,1739,The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.,"Is the triple ""Pentobarbital causes insomnia"" supported by the sentence: ""The effects of amphetamine and pentobarbital upon electrographic state were studied in naive cats and cats with forebrain lesions that induce insomnia.""?",False, +25778415,Pentobarbital affects insomnia,1740,"Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""","Is the triple ""Pentobarbital affects insomnia"" supported by the sentence: ""Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in ""hospital insomnia.""""?",False, +13642757,Pentobarbital disrupts status epilepticus,1741,"The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.","Is the triple ""Pentobarbital disrupts status epilepticus"" supported by the sentence: ""The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.""?",False, +23761012,Amobarbital prevents osteoarthritis,1742,"A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).","Is the triple ""Amobarbital prevents osteoarthritis"" supported by the sentence: ""A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA).""?",False, +26983984,Moxisylyte causes erectile dysfunction,1743,"Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.","Is the triple ""Moxisylyte causes erectile dysfunction"" supported by the sentence: ""Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response.""?",False, +26385811,Mepyramine prevents allergic disease,1744,Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).,"Is the triple ""Mepyramine prevents allergic disease"" supported by the sentence: ""Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h (P less than 0.01).""?",False, +27140633,Promethazine subclass of Promethazine sulfoxide,1745,Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.,"Is the triple ""Promethazine subclass of Promethazine sulfoxide"" supported by the sentence: ""Promethazine sulfoxide is devoid of the antioxidant effect exhibited by promethazine on rat brain synaptosomes.""?",False, +19124534,Promethazine related to Vomiting,1746,"A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.","Is the triple ""Promethazine related to Vomiting"" supported by the sentence: ""A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia.""?",False, +26252918,Promethazine causes Vomiting,1747,"Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.","Is the triple ""Promethazine causes Vomiting"" supported by the sentence: ""Male mixed-breed dogs were used to evaluate the effectiveness of cimetidine (Cim), promethazine (Pro), and thiethylperazine (Thi), singly and in combination, to raise the threshold for radiation-induced emesis.""?",False, +8157500,Promethazine causes depressive disorder,1748,Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.,"Is the triple ""Promethazine causes depressive disorder"" supported by the sentence: ""Treatment of the patient and her unusual sensitivity to meperidine and promethazine that caused a depression into Cheyne-Stokes respiration and hypotension are described.""?",False, +19547748,Promethazine affects Vomiting,1749,"The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0.05).""?",False, +12404928,Promethazine affects Pruritus,1750,"Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.","Is the triple ""Promethazine affects Pruritus"" supported by the sentence: ""Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.""?",False, +10742218,Promethazine affects Nausea,1751,The effect of promethazine in nausea and vomiting of pregnancy.,"Is the triple ""Promethazine affects Nausea"" supported by the sentence: ""The effect of promethazine in nausea and vomiting of pregnancy.""?",False, +10228295,Promethazine affects central nervous system origin vertigo,1752,"We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.","Is the triple ""Promethazine affects central nervous system origin vertigo"" supported by the sentence: ""We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity.""?",False, +7912966,Promethazine affects Vomiting,1753,"STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.","Is the triple ""Promethazine affects Vomiting"" supported by the sentence: ""STUDY OBJECTIVES: To determine the incidence of postoperative nausea and vomiting when a combination of ondansetron and promethazine is given prophylactically, and to ascertain the effect of postoperative nausea and vomiting on recovery room duration and patient satisfaction.""?",False, +13616931,Promethazine disrupts Nausea,1754,"Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).","Is the triple ""Promethazine disrupts Nausea"" supported by the sentence: ""Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm).""?",False, +17497020,Promethazine prevents central nervous system origin vertigo,1755,OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.,"Is the triple ""Promethazine prevents central nervous system origin vertigo"" supported by the sentence: ""OBJECTIVE: This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.""?",False, +11541778,Promethazine prevents Pruritus,1756,RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.,"Is the triple ""Promethazine prevents Pruritus"" supported by the sentence: ""RESULTS: Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience.""?",False, +7912965,Promethazine prevents Vomiting,1757,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Vomiting"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, +7912964,Promethazine prevents Nausea,1758,Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.,"Is the triple ""Promethazine prevents Nausea"" supported by the sentence: ""Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery.""?",False, +25750000,Clemastine causes urticaria,1759,"The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.","Is the triple ""Clemastine causes urticaria"" supported by the sentence: ""The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.""?",False, +25747466,Clemastine affects urticaria,1760,"The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.","Is the triple ""Clemastine affects urticaria"" supported by the sentence: ""The effect of ranitidine, alone and in combination with clemastine, on allergen-induced cutaneous wheal-and-flare reactions in human skin.""?",False, +19433677,Clemastine affects Pruritus,1761,"The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.","Is the triple ""Clemastine affects Pruritus"" supported by the sentence: ""The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale.""?",False, +25634655,Clemastine disrupts urticaria,1762,"Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.","Is the triple ""Clemastine disrupts urticaria"" supported by the sentence: ""Local injection of the anti-histamine (H1) drug clemastine produced only partial inhibition of responses, while almost totally abolishing histamine-induced wheals.""?",False, +24612586,Clemastine prevents urticaria,1763,"An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.","Is the triple ""Clemastine prevents urticaria"" supported by the sentence: ""An H1-receptor antagonist, clemastine, initially reduced the wheal and flare reaction but did not influence the effect of clonidine.""?",False, +17916924,Clemastine prevents dermatitis,1764,"The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.","Is the triple ""Clemastine prevents dermatitis"" supported by the sentence: ""The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.""?",False, +24699384,Clemastine predisposes allergic disease,1765,"To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.","Is the triple ""Clemastine predisposes allergic disease"" supported by the sentence: ""To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16-42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.""?",False, +25081855,Tiapride affects Dopamine D2 Receptor,1766,"Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.","Is the triple ""Tiapride affects Dopamine D2 Receptor"" supported by the sentence: ""Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.""?",False, +19553406,Amisulpride causes schizophrenia,1767,rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.,"Is the triple ""Amisulpride causes schizophrenia"" supported by the sentence: ""rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride.""?",False, +9337142,Amisulpride causes psychotic disorder,1768,"Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.","Is the triple ""Amisulpride causes psychotic disorder"" supported by the sentence: ""Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.""?",False, +24415555,Amisulpride affects depressive disorder,1769,"The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.","Is the triple ""Amisulpride affects depressive disorder"" supported by the sentence: ""The use of amisulpride predicted belonging to the Strong response group, while unemployment, depression, and negative psychotic symptoms at baseline increased the chance of belonging to the Slight response group, indicating a poor response to antipsychotic drug treatment.""?",False, +8493076,Amisulpride affects schizophrenia,1770,"In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.","Is the triple ""Amisulpride affects schizophrenia"" supported by the sentence: ""In conclusion, amisulpride is globally superior to haloperidol in the treatment of acute exacerbations of schizophrenia and significantly improves patients' quality of life and social adjustment.""?",False, +20532376,Amisulpride prevents Postoperative Nausea and Vomiting,1771,"Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.","Is the triple ""Amisulpride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Intravenous (IV) amisulpride, a well-studied D2/D3 antagonist, has been shown in trials to prevent PONV.""?",False, +19821343,Amisulpride prevents Nausea,1772,Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.,"Is the triple ""Amisulpride prevents Nausea"" supported by the sentence: ""Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study.""?",False, +11149280,Remoxipride physically interacts with Dopamine D2 Receptor,1773,Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.,"Is the triple ""Remoxipride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is an atypical antipsychotic displaying selective binding to the dopamine D2 receptor.""?",False, +9174370,Remoxipride affects Dopamine D2 Receptor,1774,Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.,"Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Remoxipride is a substituted benzamide that acts as a weak but very selective antagonist of dopamine D2 receptors.""?",False, +24158881,Remoxipride affects Dopamine D2 Receptor,1775,"Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.","Is the triple ""Remoxipride affects Dopamine D2 Receptor"" supported by the sentence: ""Antagonism of D2R by means of intracerebral treatment with remoxipride, completely prevented the expression of both short-term (<1 h) and long-term potentiation (>4 h), as well as the expression of short-term depression (STD, <1 h) in the hippocampal CA1 region.""?",False, +20394421,Levosulpiride affects Dopamine D2 Receptor,1776,"Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.","Is the triple ""Levosulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride.""?",False, +26880772,Nitroglycerin related to coronary artery disorder,1777,Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.,"Is the triple ""Nitroglycerin related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease.""?",False, +26139329,Nitroglycerin related to hypertensive disorder,1778,A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.,"Is the triple ""Nitroglycerin related to hypertensive disorder"" supported by the sentence: ""A comparison of the arterial vasodilating potency of nitroglycerin and nitroprusside in patients in whom acute hypertension develops following coronary artery bypass surgery revealed that equal lowering of arterial pressure and systemic vascular resistance could be demonstrated in 85 percent of the patients with comparable infusion rates.""?",False, +21173297,Nitroglycerin related to injury,1779,"Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.","Is the triple ""Nitroglycerin related to injury"" supported by the sentence: ""Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4.""?",False, +26585664,Nitroglycerin causes Raynaud disease,1780,Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.,"Is the triple ""Nitroglycerin causes Raynaud disease"" supported by the sentence: ""Elucidating the mechanism of action of the beneficial and adverse effects of GTN at the molecular level may shed light on the pathogenesis of Raynaud's phenomenon and its treatment.""?",False, +26278376,Nitroglycerin causes Angina pectoris,1781,Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.,"Is the triple ""Nitroglycerin causes Angina pectoris"" supported by the sentence: ""Different effects of nitroglycerin and nifedipine on regional myocardial blood flow during pacing induced angina pectoris.""?",False, +26148974,Nitroglycerin causes myocardial infarction,1782,Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.,"Is the triple ""Nitroglycerin causes myocardial infarction"" supported by the sentence: ""Whether a paradoxical reaction to glyceryl trinitrate may have triggered the development of myocardial infarction in this case is uncertain.""?",False, +15949436,Nitroglycerin causes injury,1783,"If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.","Is the triple ""Nitroglycerin causes injury"" supported by the sentence: ""If our animal studies showing that nitroglycerin tolerance increases cardiac injury upon ischemic insult are corroborated in humans, activators of ALDH2 such as Alda-1 may help to protect patients with myocardial infarction from this nitroglycerin-induced increase in cardiac injury while maintaining the cardiac benefits of the increased nitric oxide concentrations produced by nitroglycerin.""?",False, +15624022,Nitroglycerin causes Inflammation,1784,Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.,"Is the triple ""Nitroglycerin causes Inflammation"" supported by the sentence: ""Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.""?",False, +14985558,Nitroglycerin causes hypertensive disorder,1785,STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.,"Is the triple ""Nitroglycerin causes hypertensive disorder"" supported by the sentence: ""STUDY OBJECTIVE: We tested the hypothesis that epinephrine (1 mg) co-administered with vasopressin (40 IU) +/- nitroglycerin (300 MUg) results in higher diastolic blood pressure than epinephrine alone.""?",False, +8402702,Nitroglycerin causes Pain,1786,Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.,"Is the triple ""Nitroglycerin causes Pain"" supported by the sentence: ""Previous uncontrolled studies have reported that the local use of anaesthetic agents in the area of the sphenopalatine fossa is able to extinguish nitroglycerin (NTG)-induced pain in CH.""?",False, +7629693,Nitroglycerin causes hypotensive disorder,1787,"In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.","Is the triple ""Nitroglycerin causes hypotensive disorder"" supported by the sentence: ""In contrast, the hypotension induced by glyceryl trinitrate (GTN) in LPS-treated rats was not distinguishable from that produced in vehicle-treated rats.""?",False, +26786108,Nitroglycerin affects coronary artery disorder,1788,Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Neither the pattern of angina pectoris nor the response to nitroglycerin was dependent upon the coexistence of significant coronary artery disease.""?",False, +26278652,Nitroglycerin affects hypotensive disorder,1789,"This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.","Is the triple ""Nitroglycerin affects hypotensive disorder"" supported by the sentence: ""This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin.""?",False, +25994904,Nitroglycerin affects Raynaud disease,1790,"The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.","Is the triple ""Nitroglycerin affects Raynaud disease"" supported by the sentence: ""The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate.""?",False, +25747829,Nitroglycerin affects erectile dysfunction,1791,Impotence responsive to glyceryl trinitrate.,"Is the triple ""Nitroglycerin affects erectile dysfunction"" supported by the sentence: ""Impotence responsive to glyceryl trinitrate.""?",False, +25260538,Nitroglycerin affects Muscle spasm,1792,Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.,"Is the triple ""Nitroglycerin affects Muscle spasm"" supported by the sentence: ""Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.""?",False, +23178151,Nitroglycerin affects coronary artery disorder,1793,Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.,"Is the triple ""Nitroglycerin affects coronary artery disorder"" supported by the sentence: ""Purpose: To evaluate the influence of applying nitroglycerin (NTG) on detecting significant coronary artery disease (CAD) and NTG-induced coronary vasodilation using coronary MR angiography in patients suspected of having CAD.""?",False, +20885558,Nitroglycerin affects injury,1794,Cardiac output effects of nitroglycerin in experimental lung injury.,"Is the triple ""Nitroglycerin affects injury"" supported by the sentence: ""Cardiac output effects of nitroglycerin in experimental lung injury.""?",False, +18491008,Nitroglycerin affects Hot flashes,1795,"After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).","Is the triple ""Nitroglycerin affects Hot flashes"" supported by the sentence: ""After discontinuing nitroglycerin, participants reported an average 23% increase in frequency of any hot flashes (P = 0.041) and 96% increase in moderate-to-severe hot flashes (P < 0.001).""?",False, +14421188,Nitroglycerin affects Angina pectoris,1796,"Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).","Is the triple ""Nitroglycerin affects Angina pectoris"" supported by the sentence: ""Eligible patients had chronic angina pectoris with symptom-limited, reproducible treadmill tests and were responsive to sublingual nitroglycerin (n = 562).""?",False, +13478654,Nitroglycerin affects osteoporosis,1797,The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.,"Is the triple ""Nitroglycerin affects osteoporosis"" supported by the sentence: ""The preventive effects of nitroglycerine (NG) on glucocorticoid-induced osteoporosis in growing rats were studied.""?",False, +11707783,Nitroglycerin affects Pain,1798,"We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.","Is the triple ""Nitroglycerin affects Pain"" supported by the sentence: ""We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.""?",False, +11174035,Nitroglycerin affects hypertensive disorder,1799,"The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.","Is the triple ""Nitroglycerin affects hypertensive disorder"" supported by the sentence: ""The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.""?",False, +10595566,Nitroglycerin affects stroke disorder,1800,[On the effect of nitroglycerin on the stroke- and minute volume of the heart].,"Is the triple ""Nitroglycerin affects stroke disorder"" supported by the sentence: ""[On the effect of nitroglycerin on the stroke- and minute volume of the heart].""?",False, +8601510,Nitroglycerin affects myocardial ischemia,1801,Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.,"Is the triple ""Nitroglycerin affects myocardial ischemia"" supported by the sentence: ""Venodilatation with consequent reduction in left ventricular filling and end-diastolic wall stress is an important mechanism for the beneficial effects of nitroglycerin in ischemic heart disease and in left ventricular failure.""?",False, +8521770,Nitroglycerin affects phlebitis,1802,Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.,"Is the triple ""Nitroglycerin affects phlebitis"" supported by the sentence: ""Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation.""?",False, +8049127,Nitroglycerin affects ischemia reperfusion injury,1803,Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.,"Is the triple ""Nitroglycerin affects ischemia reperfusion injury"" supported by the sentence: ""Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.""?",False, +26813951,Nitroglycerin disrupts myocardial ischemia,1804,Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.,"Is the triple ""Nitroglycerin disrupts myocardial ischemia"" supported by the sentence: ""Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction.""?",False, +26590847,Nitroglycerin disrupts hypertensive disorder,1805,"CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.","Is the triple ""Nitroglycerin disrupts hypertensive disorder"" supported by the sentence: ""CONCLUSION: Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension.""?",False, +24386334,Nitroglycerin disrupts phlebitis,1806,"The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).","Is the triple ""Nitroglycerin disrupts phlebitis"" supported by the sentence: ""The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92).""?",False, +19274234,Nitroglycerin disrupts injury,1807,"Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.","Is the triple ""Nitroglycerin disrupts injury"" supported by the sentence: ""Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.""?",False, +10081147,Nitroglycerin disrupts Marchiafava-Bignami disease,1808,These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.,"Is the triple ""Nitroglycerin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""These data confirm previous findings and show that nitroglycerin counteracts the estrogen deficiency-induced osteopenia in the ovariectomised rat model.""?",False, +9796564,Nitroglycerin disrupts Pain,1809,At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.,"Is the triple ""Nitroglycerin disrupts Pain"" supported by the sentence: ""At 8 weeks the magnitude of the difference between 0.4 percent nitroglycerin and control was a 21 percent reduction in average pain.""?",False, +25569906,Nitroglycerin prevents phlebitis,1810,CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.,"Is the triple ""Nitroglycerin prevents phlebitis"" supported by the sentence: ""CONCLUSION: External use of both sesame oil and nitroglycerin is effective in reducing chemotherapy-induced phlebitis.""?",False, +21983895,Nitroglycerin prevents Muscle spasm,1811,Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.,"Is the triple ""Nitroglycerin prevents Muscle spasm"" supported by the sentence: ""Intra-arterial vasodilators including verapamil and nitroglycerine were administered to prevent radial artery spasm.""?",False, +20473117,Nitroglycerin prevents Inflammation,1812,Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.,"Is the triple ""Nitroglycerin prevents Inflammation"" supported by the sentence: ""Glyceryl trinitrate has been inferred to reduce pain and inflammation secondary to their nitric oxide-producing action.""?",False, +18491009,Nitroglycerin prevents Hot flashes,1813,CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.,"Is the triple ""Nitroglycerin prevents Hot flashes"" supported by the sentence: ""CONCLUSIONS: Continuous nitroglycerin may substantially and reversibly decrease hot flash frequency and severity.""?",False, +17804368,Nitroglycerin prevents hypertensive disorder,1814,"Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.","Is the triple ""Nitroglycerin prevents hypertensive disorder"" supported by the sentence: ""Single intravenous injection (0.25 mg) or drip infusion (0.3 micrograms/(kg.min) of nitroglycerin effectively prevented arterial hypertension, decreased peripheral vascular resistance and myocardial oxygen demand.""?",False, +11496690,Nitroglycerin prevents ischemia reperfusion injury,1815,CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.,"Is the triple ""Nitroglycerin prevents ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Administration of the NTG reduced the ischemia-reperfusion injury in the rat donor lungs.""?",False, +10695579,Nitroglycerin prevents Angina pectoris,1816,A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.,"Is the triple ""Nitroglycerin prevents Angina pectoris"" supported by the sentence: ""A CONTROLLED TRIAL OF LONG-ACTING GLYCERYL TRINITRATE FOR THE PREVENTION OF ANGINA PECTORIS.""?",False, +10573276,Nitroglycerin prevents myocardial infarction,1817,Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.,"Is the triple ""Nitroglycerin prevents myocardial infarction"" supported by the sentence: ""Prevention of myocardial infarction by nitroglycerin plus intravenous beta-blockers.""?",False, +9096899,Nitroglycerin prevents Pain,1818,Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.,"Is the triple ""Nitroglycerin prevents Pain"" supported by the sentence: ""Our study attempts to test the hypothesis that topical nitroglycerin applied to the perianal region is beneficial in reducing pain after hemorrhoidectomy.""?",False, +9057729,Nitroglycerin prevents Shock,1819,"Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).","Is the triple ""Nitroglycerin prevents Shock"" supported by the sentence: ""Nitroglycerin prevented alveolar collapse, which was increased in the other IR groups (p = 0.013).""?",False, +8235862,Nitroglycerin prevents Marchiafava-Bignami disease,1820,"Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).","Is the triple ""Nitroglycerin prevents Marchiafava-Bignami disease"" supported by the sentence: ""Application of NG once daily also completely prevented (+6.2 +/- 2.8%; p < 0.01) the ovariectomy-induced bone loss (i.e., it was as effective as estrogen).""?",False, +7713034,Nitroglycerin prevents injury,1821,"It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.","Is the triple ""Nitroglycerin prevents injury"" supported by the sentence: ""It is concluded, first, that interventions that modify the severity of ischemia can be evaluated by measuring intramural carbon dioxide tension; second, that propranolol, hyaluronidase, and nitroglycerin reduce ischemic injury, whereas isoproterenol increases it; and third, that the combination of propranolol, hyaluronidase, and nitroglycerin exerts an additive beneficial effect on ischemia.""?",False, +13750741,Nitroglycerin exacerbates myocardial ischemia,1822,"RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).","Is the triple ""Nitroglycerin exacerbates myocardial ischemia"" supported by the sentence: ""RESULTS: Evidence of exercise-induced myocardial ischemia was found in all patients presenting with a frank cardiac lactate production (10.2+/-3.3%) which was significantly aggravated by NTG (26.0+/-7.5%, P<0.003).""?",False, +20483551,Nitroglycerin predisposes myocardial ischemia,1823,OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.,"Is the triple ""Nitroglycerin predisposes myocardial ischemia"" supported by the sentence: ""OBJECTIVES: To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia.""?",False, +9897513,Nitroglycerin predisposes Angina pectoris,1824,Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.,"Is the triple ""Nitroglycerin predisposes Angina pectoris"" supported by the sentence: ""Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department.""?",False, +20924645,Isosorbide dinitrate related to myocardial ischemia,1825,Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.,"Is the triple ""Isosorbide dinitrate related to myocardial ischemia"" supported by the sentence: ""Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.""?",False, +10616906,Isosorbide dinitrate related to Angina pectoris,1826,Isosorbide dinitrate in angina pectoris.,"Is the triple ""Isosorbide dinitrate related to Angina pectoris"" supported by the sentence: ""Isosorbide dinitrate in angina pectoris.""?",False, +9112334,Isosorbide dinitrate related to coronary artery disorder,1827,Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.,"Is the triple ""Isosorbide dinitrate related to coronary artery disorder"" supported by the sentence: ""Effects of isosorbide dinitrate on the response to atrial pacing in coronary heart disease.""?",False, +26334868,Isosorbide dinitrate affects Angina pectoris,1828,The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.,"Is the triple ""Isosorbide dinitrate affects Angina pectoris"" supported by the sentence: ""The effect of pindolol and isosorbide dinitrate and their combination on exercise tolerance and ECG changes in angina pectoris.""?",False, +10884689,Isosorbide dinitrate affects myocardial ischemia,1829,The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.,"Is the triple ""Isosorbide dinitrate affects myocardial ischemia"" supported by the sentence: ""The effect of intracoronary isosorbide dinitrate on provoked myocardial ischaemia during percutaneous transluminal coronary angioplasty (PTCA) was studied in 60 patients who had at least 1 mm electrocardiographic (ECG) ST segment deviation during a 70 s control balloon inflation period.""?",False, +9112335,Isosorbide dinitrate prevents myocardial ischemia,1830,"To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.","Is the triple ""Isosorbide dinitrate prevents myocardial ischemia"" supported by the sentence: ""To study the efficacy of isosorbide dinitrate in prevention of myocardial ischemia, 20 patients with angiographically proved coronary artery disease underwent atrial pacing (mean rate 138/min) before (P1), 10 minutes after (P2) and 65 minutes after (P3) sublingual administration of 5 mg of isosorbide dinitrate.""?",False, +17782283,Sulpiride physically interacts with Dopamine D2 Receptor,1831,"The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""The onset and persistence of changes in 3H-spiroperidol binding to dopamine (DA) D2 receptors were examined in rat mesolimbic and striatal brain regions following daily administration of haloperidol, molindone, or sulpiride for 3, 7, 14, or 28 days.""?",False, +7084056,Sulpiride physically interacts with Dopamine D2 Receptor,1832,"Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.","Is the triple ""Sulpiride physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""Consistent with sulpiride's affinity at dopamine D2 receptors, this action of sulpiride was stereoselective: S(-)-sulpiride was active whereas R(+)-sulpiride was inactive.""?",False, +25690684,Sulpiride causes depressive disorder,1833,"Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.","Is the triple ""Sulpiride causes depressive disorder"" supported by the sentence: ""Bilateral injections of haloperidol or (-)sulpiride (0.001-1 microgram) into the selected limbic and extrapyramidal areas caused dose-related depression of mouse spontaneous climbing, the limbic areas, particularly the nucleus accumbens, being the most sensitive.""?",False, +26343015,Sulpiride affects schizophrenia,1834,"On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.","Is the triple ""Sulpiride affects schizophrenia"" supported by the sentence: ""On the other hand, the disinhibitory effect of sulpiride in schizophrenia may also involve the preferential pre-synaptic action of the drug coupled with the specificity of post-synaptic action to result in little sedation or motor retardation.""?",False, +23882267,Sulpiride affects anxiety,1835,Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.,"Is the triple ""Sulpiride affects anxiety"" supported by the sentence: ""Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.""?",False, +8960439,Sulpiride affects depressive disorder,1836,"This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls.""?",False, +8364166,Sulpiride affects Dopamine D2 Receptor,1837,"Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.","Is the triple ""Sulpiride affects Dopamine D2 Receptor"" supported by the sentence: ""Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride.""?",False, +7538297,Sulpiride affects depressive disorder,1838,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sulpiride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, +25756981,Sulpiride disrupts depressive disorder,1839,"(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.","Is the triple ""Sulpiride disrupts depressive disorder"" supported by the sentence: ""(-)Sulpiride, injected into the substantia nigra, antagonised the locomotor depression although the partial antagonism of the elevation in the level of dopamine in the striatum and of the reduction in levels of DOPAC did not achieve significance.""?",False, +8859505,Sulpiride disrupts anxiety,1840,"Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.","Is the triple ""Sulpiride disrupts anxiety"" supported by the sentence: ""Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it.""?",False, +26753868,Isosorbide mononitrate causes Angina pectoris,1841,"To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.","Is the triple ""Isosorbide mononitrate causes Angina pectoris"" supported by the sentence: ""To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia.""?",False, +15856723,Isosorbide mononitrate affects Angina pectoris,1842,Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.,"Is the triple ""Isosorbide mononitrate affects Angina pectoris"" supported by the sentence: ""Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.""?",False, +24979081,Isosorbide mononitrate prevents vascular disorder,1843,METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.,"Is the triple ""Isosorbide mononitrate prevents vascular disorder"" supported by the sentence: ""METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression.""?",False, +22319748,Isosorbide mononitrate prevents Angina pectoris,1844,"Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.","Is the triple ""Isosorbide mononitrate prevents Angina pectoris"" supported by the sentence: ""Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades.""?",False, +23203614,Ribociclib related to squamous cell carcinoma,1845,"Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.","Is the triple ""Ribociclib related to squamous cell carcinoma"" supported by the sentence: ""Preclinical Evaluation of the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor, Ribociclib, and Cetuximab in Squamous Cell Carcinoma of the Head and Neck.""?",False, +23890460,Abemaciclib related to non-small cell lung carcinoma,1846,Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.,"Is the triple ""Abemaciclib related to non-small cell lung carcinoma"" supported by the sentence: ""Conclusions: The combination of abemaciclib and pembrolizumab in stage IV NSCLC resulted in greater toxicity compared with that previously reported for each individual treatment.""?",False, +24133672,Abemaciclib affects neoplasm,1847,"We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.","Is the triple ""Abemaciclib affects neoplasm"" supported by the sentence: ""We then confirmed that abemaciclib (CDK4/6 selective inhibitor) could inhibit the proliferation of ascites cells, and the combination of abemaciclib and MS275 had synergistic anti-tumor effect.""?",False, +23820208,Abemaciclib disrupts neoplasm,1848,Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.,"Is the triple ""Abemaciclib disrupts neoplasm"" supported by the sentence: ""Abemaciclib inhibits tumor formation and growth in a dose-dependent manner without causing significant drug toxicity in mice.""?",False, +7114439,Sodium Chloride subclass of Electrolytes,1849,"LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.","Is the triple ""Sodium Chloride subclass of Electrolytes"" supported by the sentence: ""LiCl and NaCl were used as background electrolytes at concentrations of 10(-1), 10(-2), and 10(-3) mol L-1.""?",False, +27178225,Sodium Chloride related to hypoglycemia,1850,Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.,"Is the triple ""Sodium Chloride related to hypoglycemia"" supported by the sentence: ""Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia.""?",False, +26906663,Sodium Chloride related to ventricular septal defect,1851,"When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).","Is the triple ""Sodium Chloride related to ventricular septal defect"" supported by the sentence: ""When Hy-Vac SPF type V embryos were exposed to either 0.20 ml 50% ethanol in CRS or to 0.20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34.1% compared with a 3.6% incidence in the controls (P = 0.0017).""?",False, +26538206,Sodium Chloride related to papilloma,1852,The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.,"Is the triple ""Sodium Chloride related to papilloma"" supported by the sentence: ""The incidences of bladder transitional cell carcinomas and papillomas were 90 and 55% in the group treated with 3% melamine alone; 0 and 15% in the group treated with 3% melamine and 10% NaCl; and 21 and 42% in group treated with 1% melamine alone; and zero in the other groups.""?",False, +26529472,Sodium Chloride related to chronic obstructive pulmonary disease,1853,"Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.","Is the triple ""Sodium Chloride related to chronic obstructive pulmonary disease"" supported by the sentence: ""Hormonal, renal, and autonomic nerve factors involved in the excretion of sodium and water during dynamic salt and water loading in hypoxaemic chronic obstructive pulmonary disease.""?",False, +26267091,Sodium Chloride related to Sepsis,1854,"The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.","Is the triple ""Sodium Chloride related to Sepsis"" supported by the sentence: ""The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.""?",False, +26209731,Sodium Chloride related to cataract,1855,Basic data supporting the use of the l-lysine salt of bendazac in cataract.,"Is the triple ""Sodium Chloride related to cataract"" supported by the sentence: ""Basic data supporting the use of the l-lysine salt of bendazac in cataract.""?",False, +25917183,Sodium Chloride related to Hypoxemia,1856,[Effect of vitamin C on water-salt metabolism in experimental hypoxia].,"Is the triple ""Sodium Chloride related to Hypoxemia"" supported by the sentence: ""[Effect of vitamin C on water-salt metabolism in experimental hypoxia].""?",False, +20673450,Sodium Chloride related to Alzheimer disease,1857,The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.,"Is the triple ""Sodium Chloride related to Alzheimer disease"" supported by the sentence: ""The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints.""?",False, +20617514,Sodium Chloride related to type 2 diabetes mellitus,1858,"Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.","Is the triple ""Sodium Chloride related to type 2 diabetes mellitus"" supported by the sentence: ""Conclusions: The decreased PON1-salt may be considered as a risk factor for atherosclerosis in T2D, therefore, understanding the associations between PON1-salt as an important although neglected property and atherogenic indices may be valuable in T2D.""?",False, +20321366,Sodium Chloride related to type 1 diabetes mellitus,1859,"In addition, NEN could impede the progression of DKD in T1D.","Is the triple ""Sodium Chloride related to type 1 diabetes mellitus"" supported by the sentence: ""In addition, NEN could impede the progression of DKD in T1D.""?",False, +19962817,Sodium Chloride related to Inflammation,1860,"These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.","Is the triple ""Sodium Chloride related to Inflammation"" supported by the sentence: ""These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.""?",False, +19891172,Sodium Chloride related to acute lung injury,1861,BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.,"Is the triple ""Sodium Chloride related to acute lung injury"" supported by the sentence: ""BACKGROUND: The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats.""?",False, +19636264,Sodium Chloride related to ischemic disease,1862,"Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.","Is the triple ""Sodium Chloride related to ischemic disease"" supported by the sentence: ""Theoretical safety concerns remain for infiltration, thrombophlebitis, tissue ischemia, and venous thrombosis associated with continuous 3% HTS administered via peripheral intravenous (pIV) catheters.""?",False, +19577743,Sodium Chloride related to spinal cord injury,1863,OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.,"Is the triple ""Sodium Chloride related to spinal cord injury"" supported by the sentence: ""OBJECTIVES: The objectives of the study were (i) to examine left ventricular (LV) diastolic function at rest and during rapid saline infusion in those with spinal cord injury (SCI) and (ii) to determine the contribution of blood volume on the purported diastolic impairments in individuals with SCI.""?",False, +19497082,Sodium Chloride related to primary ciliary dyskinesia,1864,A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.,"Is the triple ""Sodium Chloride related to primary ciliary dyskinesia"" supported by the sentence: ""A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia.""?",False, +18975700,Sodium Chloride related to bacterial infectious disease,1865,Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.,"Is the triple ""Sodium Chloride related to bacterial infectious disease"" supported by the sentence: ""Differentially expressed proteins were analysed in DAVID interface to isolate functional pathways involved in the response to bacterial infection and which are influenced by environmental salinity changes.""?",False, +18966398,Sodium Chloride related to osteoarthritis,1866,"CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.","Is the triple ""Sodium Chloride related to osteoarthritis"" supported by the sentence: ""CONCLUSION: Based on available trial data, intra-articular hyaluronic acid showed a better effect than intra-articular saline on pain reduction in osteoarthritis.""?",False, +18860303,Sodium Chloride related to bone fracture,1867,Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).,"Is the triple ""Sodium Chloride related to bone fracture"" supported by the sentence: ""Wastewater produced by hydraulic fracturing for oil and gas production is characterized by high salinity and high chemical oxygen demand (COD).""?",False, +18738706,Sodium Chloride related to toxic shock syndrome,1868,CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.,"Is the triple ""Sodium Chloride related to toxic shock syndrome"" supported by the sentence: ""CONCLUSION: The 3% hypertonic saline was effective as resuscitation fluid in pediatric septic shock with respect to restoration of hemodynamic stability without obvious side effects.""?",False, +18679247,Sodium Chloride related to Electrolytes,1869,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, +18617363,Sodium Chloride related to iron deficiency anemia,1870,"At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.","Is the triple ""Sodium Chloride related to iron deficiency anemia"" supported by the sentence: ""At 18 DAA, clear reduction in PN under the ST and SW treatments was observed, which was associated with chlorosis, damages to the photosystem II (PSII), enhanced lipid peroxidation, and depressed ATP synthesis in the chloroplasts of the flag leaf.""?",False, +18287282,Sodium Chloride related to Pruritus,1871,"The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).","Is the triple ""Sodium Chloride related to Pruritus"" supported by the sentence: ""The incidence of OIP, determined by self-report and treatment, was not different between groups: 22% in the NOSA group vs 36% in the control group (mean difference, -15%; 95% confidence interval [CI], -33 to 4; P = 0.164).""?",False, +17603340,Sodium Chloride related to brain injury,1872,Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.,"Is the triple ""Sodium Chloride related to brain injury"" supported by the sentence: ""Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.""?",False, +17533385,Sodium Chloride related to myocardial infarction,1873,Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.,"Is the triple ""Sodium Chloride related to myocardial infarction"" supported by the sentence: ""Cardiac hypertrophy and salt status in chronic myocardial infarction in the rat: effects of enalapril versus salt restriction.""?",False, +17525035,Sodium Chloride related to coronary artery disorder,1874,The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.,"Is the triple ""Sodium Chloride related to coronary artery disorder"" supported by the sentence: ""The data obtained provide an insight into the role of salt concentrations (10 and 20 g/l) in carbon dioxide bath water (1.2 g/l) applied for the traditional treatment of the patients with hypertensive disease associated with concomitant coronary heart disease and musculoskeletal pathology.""?",False, +17213013,Sodium Chloride related to hepatocellular carcinoma,1875,"In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.","Is the triple ""Sodium Chloride related to hepatocellular carcinoma"" supported by the sentence: ""In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer.""?",False, +17202845,Sodium Chloride related to Parkinson disease,1876,These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.,"Is the triple ""Sodium Chloride related to Parkinson disease"" supported by the sentence: ""These results strongly suggest a promising therapeutic role of this simple modified saline in PD and other neuroinflammatory disorders.""?",False, +16886803,Sodium Chloride related to ischemia reperfusion injury,1877,Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.,"Is the triple ""Sodium Chloride related to ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage.""?",False, +16594665,Sodium Chloride related to Pain,1878,"In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.","Is the triple ""Sodium Chloride related to Pain"" supported by the sentence: ""In this study, we tested the hypothesis that two repeated intramuscular infusions of acidic saline into the human masseter muscle is associated with pain, mechanical allodynia and release of algesic substances.""?",False, +16433967,Sodium Chloride related to liver and intrahepatic bile duct neoplasm,1879,Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.,"Is the triple ""Sodium Chloride related to liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Changes in hepatic blood flow during transcatheter arterial infusion with heated saline in hepatic VX2 tumor.""?",False, +15412515,Sodium Chloride related to subarachnoid hemorrhage,1880,Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).,"Is the triple ""Sodium Chloride related to subarachnoid hemorrhage"" supported by the sentence: ""Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH).""?",False, +14710472,Sodium Chloride related to bronchiolitis,1881,"High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.","Is the triple ""Sodium Chloride related to bronchiolitis"" supported by the sentence: ""High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.""?",False, +14037713,Sodium Chloride related to ventricular tachycardia,1882,"Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.","Is the triple ""Sodium Chloride related to ventricular tachycardia"" supported by the sentence: ""Pretreatment of 3-NP significantly reduced infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) levels, and incidence of ventricular tachycardia (VT) compared with the control group receiving saline only.""?",False, +13928740,Sodium Chloride related to pulmonary edema,1883,"Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.","Is the triple ""Sodium Chloride related to pulmonary edema"" supported by the sentence: ""Salt and water overload is associated with pulmonary edema, ileus, and delayed wound healing.""?",False, +13375642,Sodium Chloride related to Insulin resistance,1884,"CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.","Is the triple ""Sodium Chloride related to Insulin resistance"" supported by the sentence: ""CONCLUSIONS: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.""?",False, +13343201,Sodium Chloride related to Hypernatremia,1885,CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.,"Is the triple ""Sodium Chloride related to Hypernatremia"" supported by the sentence: ""CONCLUSIONS: The bipolar transurethral resection in saline system is as efficacious as monopolar transurethral prostate resection but it is safer than the latter because of the lesser decrease in postoperative hypernatremia and the smaller risk of transurethral resection syndrome.""?",False, +13277977,Sodium Chloride related to diabetic ketoacidosis,1886,The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.,"Is the triple ""Sodium Chloride related to diabetic ketoacidosis"" supported by the sentence: ""The high potency of DKA as compared to 5CITEP is supported by a strong salt link formed between its carboxylate moiety and the ammonium group of Lys-159.""?",False, +11905993,Sodium Chloride related to depressive disorder,1887,"This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.","Is the triple ""Sodium Chloride related to depressive disorder"" supported by the sentence: ""This analysis reveals that soil salt content decreases from regionally high values in isolated depressions to relatively moderate values in embanked former back swamps, with the lowest values occurring in abandoned river courses.""?",False, +11014479,Sodium Chloride related to glaucoma,1888,[Dynamics of sodium chloride in the blood in glaucoma].,"Is the triple ""Sodium Chloride related to glaucoma"" supported by the sentence: ""[Dynamics of sodium chloride in the blood in glaucoma].""?",False, +10966302,Sodium Chloride related to malaria,1889,"Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.","Is the triple ""Sodium Chloride related to malaria"" supported by the sentence: ""Results show that irrigation water use and soil salinity are significantly associated with malaria incidence, warranting further research to better understand the exact linkage mechanisms between agriculture and malaria.""?",False, +10739226,Sodium Chloride related to heart disorder,1890,[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].,"Is the triple ""Sodium Chloride related to heart disorder"" supported by the sentence: ""[Renal hemodynamics and elimination of sodium chloride in compensated heart disease in basal conditions].""?",False, +10689901,Sodium Chloride related to diabetes mellitus,1891,[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].,"Is the triple ""Sodium Chloride related to diabetes mellitus"" supported by the sentence: ""[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN].""?",False, +10566407,Sodium Chloride related to brain cancer,1892,[Water-salt and carbohydrate metabolism in brain tumors].,"Is the triple ""Sodium Chloride related to brain cancer"" supported by the sentence: ""[Water-salt and carbohydrate metabolism in brain tumors].""?",False, +10531148,Sodium Chloride related to kidney failure,1893,"[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].","Is the triple ""Sodium Chloride related to kidney failure"" supported by the sentence: ""[Low salt syndrome, caused by renal sodium chloride losses in renal insufficiency (so-called salt-losing nephritis)].""?",False, +10510273,Sodium Chloride related to Shock,1894,[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].,"Is the triple ""Sodium Chloride related to Shock"" supported by the sentence: ""[Absorption of 0.9 o/o sodium chloride injected subcutaneously in dehydration shock].""?",False, +10504585,Sodium Chloride related to tuberculosis,1895,[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].,"Is the triple ""Sodium Chloride related to tuberculosis"" supported by the sentence: ""[Treatment of tuberculosis in children with the p-aminosalicylic acid salt of isonicotinic hydrazide].""?",False, +10502982,Sodium Chloride related to nutritional disorder,1896,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to nutritional disorder"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, +10502981,Sodium Chloride related to cirrhosis of liver,1897,[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].,"Is the triple ""Sodium Chloride related to cirrhosis of liver"" supported by the sentence: ""[Migration of blood proteins caused by intravenous infusion of sodium chloride in malnutrition and liver cirrhosis].""?",False, +10487095,Sodium Chloride related to pneumonia,1898,[Water and salt content in the lung in vagus pneumonia].,"Is the triple ""Sodium Chloride related to pneumonia"" supported by the sentence: ""[Water and salt content in the lung in vagus pneumonia].""?",False, +10439781,Sodium Chloride related to acute kidney failure,1899,Patterns of renal salt loss in acute renal failure.,"Is the triple ""Sodium Chloride related to acute kidney failure"" supported by the sentence: ""Patterns of renal salt loss in acute renal failure.""?",False, +10433628,Sodium Chloride related to psoriasis,1900,[Studies on water and salt metabolism in psoriasis].,"Is the triple ""Sodium Chloride related to psoriasis"" supported by the sentence: ""[Studies on water and salt metabolism in psoriasis].""?",False, +10370762,Sodium Chloride related to Hypothermia,1901,[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].,"Is the triple ""Sodium Chloride related to Hypothermia"" supported by the sentence: ""[Biliary transport of sodium and chloride. Excretion of large amounts of NaCl in hypothermia].""?",False, +10318383,Sodium Chloride related to cardiovascular disorder,1902,Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.,"Is the triple ""Sodium Chloride related to cardiovascular disorder"" supported by the sentence: ""Multiple regression analysis with intake of salt and Keys' factor indicated that the influence of salt on cardiovascular disease to decreased and that that of low serum cholesterol on CH declined.""?",False, +10300324,Sodium Chloride related to stroke disorder,1903,"Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).","Is the triple ""Sodium Chloride related to stroke disorder"" supported by the sentence: ""Derivatives of these partially saturated aza-5[H]-phenanthridin-6-ones were designed and synthesized with tertiary amines for salt formation, thus enhancing aqueous solubility, iv formulation and their potential use in acute ischemic injuries (i.e., myocardial ischemia and stroke).""?",False, +10268953,Sodium Chloride related to brain edema,1904,"The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.","Is the triple ""Sodium Chloride related to brain edema"" supported by the sentence: ""The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.""?",False, +9985623,Sodium Chloride related to Nausea,1905,"Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.","Is the triple ""Sodium Chloride related to Nausea"" supported by the sentence: ""Both the HS-NS and HS-BS (colloid) groups had a significantly less frequent incidence of nausea and vomiting, use of rescue antiemetics, severe pain, periorbital edema, and double vision.""?",False, +9642141,Sodium Chloride related to obesity disorder,1906,"The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).","Is the triple ""Sodium Chloride related to obesity disorder"" supported by the sentence: ""The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR).""?",False, +9504754,Sodium Chloride related to asthma,1907,Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.,"Is the triple ""Sodium Chloride related to asthma"" supported by the sentence: ""Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.""?",False, +9350794,Sodium Chloride related to essential hypertension,1908,[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].,"Is the triple ""Sodium Chloride related to essential hypertension"" supported by the sentence: ""[Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension].""?",False, +9217528,Sodium Chloride related to dry eye syndrome,1909,The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.,"Is the triple ""Sodium Chloride related to dry eye syndrome"" supported by the sentence: ""The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome.""?",False, +8489872,Sodium Chloride related to injury,1910,Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.,"Is the triple ""Sodium Chloride related to injury"" supported by the sentence: ""Quantification of this effect using [H3]-mazindol autoradiography confirmed that peri-wound sprouting was significantly reduced in mice receiving BDNF or GDNF antisense infusions whilst control infusions of buffered saline or sense oligonucleotides resulted in the pronounced peri-wound sprouting response normally associated with striatal injury.""?",False, +8486278,Sodium Chloride related to cystic fibrosis,1911,"We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.","Is the triple ""Sodium Chloride related to cystic fibrosis"" supported by the sentence: ""We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.""?",False, +7822303,Sodium Chloride related to neoplasm,1912,"Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.","Is the triple ""Sodium Chloride related to neoplasm"" supported by the sentence: ""Similarly, the maximal PDT efficacy in DMSO saline was attained at 6 h postinjection, the highest HA retention point in tumor.""?",False, +7455347,Sodium Chloride related to Hypovolemia,1913,"It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.","Is the triple ""Sodium Chloride related to Hypovolemia"" supported by the sentence: ""It is widely believed that the cerebral salt-wasting syndrome (CSWS) exists as an entity distinct from the syndrome of inappropriate ADH secretion, and that it is characterized by evidence of severe renal salt wasting that results in volume depletion and hyponatremia.""?",False, +7397406,Sodium Chloride related to kidney disorder,1914,Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.,"Is the triple ""Sodium Chloride related to kidney disorder"" supported by the sentence: ""Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention.""?",False, +7259411,Sodium Chloride related to hypertensive disorder,1915,"Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.","Is the triple ""Sodium Chloride related to hypertensive disorder"" supported by the sentence: ""Substitution of NaCl, linked to hypertension, with divalent chloride salts such as MgCl2 and CaCl2 has shown limited success.""?",False, +19769676,Sodium Chloride related to Electrolytes,1916,"Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.","Is the triple ""Sodium Chloride related to Electrolytes"" supported by the sentence: ""Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl2 electrolyte being more effective than NaCl in decreasing biochar NPs transport.""?",False, +18679248,Sodium Chloride close match Electrolytes,1917,Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.,"Is the triple ""Sodium Chloride close match Electrolytes"" supported by the sentence: ""Physiological saline can hardly be treated as physiological as it contains qualitatively and quantitatively different amounts of electrolytes.""?",False, +7792933,Sodium Chloride coexists with Electrolytes,1918,"Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).","Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Counterion polarization of sodium and magnesium polystyrenesulfonate (NaPSS and MgPSS), adsorbed in an excess onto ellipsoidal beta-ferric hydrous oxide particles (beta-FeOOH), is studied in both the absence and the presence of added simple electrolytes, NaCl and MgCl(2).""?",False, +9181325,Sodium Chloride coexists with Electrolytes,1919,Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.,"Is the triple ""Sodium Chloride coexists with Electrolytes"" supported by the sentence: ""Electrolyte metabolism of muscle in the salt-losing form of congenital adrenal hyperplasia.""?",False, +27223278,Sodium Chloride derives from Electrolytes,1920,The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.,"Is the triple ""Sodium Chloride derives from Electrolytes"" supported by the sentence: ""The sodium chloride concentration of tear fluids was calculated from the calibration curve and converted to the equivalent electrolyte concentration.""?",False, +9585905,Sodium Chloride physically interacts with Electrolytes,1921,"The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The data indicate that FSS stabilizes electrolytes and body hydration during BR, while BR alone induces significant changes in electrolytes and body hydration.""?",False, +9585904,Sodium Chloride physically interacts with Electrolytes,1922,"The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.","Is the triple ""Sodium Chloride physically interacts with Electrolytes"" supported by the sentence: ""The aim was to measure the effect of FSS on catabolism, body hydration and electrolytes during BR.""?",False, +26947391,Sodium Chloride causes acute kidney tubular necrosis,1923,"Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).","Is the triple ""Sodium Chloride causes acute kidney tubular necrosis"" supported by the sentence: ""Single oral administration of pravadoline maleate (WIN 48098-6), the maleic acid salt of WIN 48098, induced acute tubular necrosis (ATN) in male and female beagle dogs at dosages > or = 40 mg/kg (WIN 48098 base (31 mg/kg) and maleic acid (9 mg/kg)).""?",False, +26813055,Sodium Chloride causes Dyspnea,1924,"When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.","Is the triple ""Sodium Chloride causes Dyspnea"" supported by the sentence: ""When water was offered with a delay of more than 5 min after the end of a run producing loss of 30-90 g water by panting, the drinking was similar to that produced by NaCl, assuming that loss of 100 g water produces the same increase in plasma sodium as 15 m-mole NaCl.""?",False, +26651944,Sodium Chloride causes severe cutaneous adverse reaction,1925,In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.,"Is the triple ""Sodium Chloride causes severe cutaneous adverse reaction"" supported by the sentence: ""In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals.""?",False, +26200221,Sodium Chloride causes melanoma,1926,In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.,"Is the triple ""Sodium Chloride causes melanoma"" supported by the sentence: ""In one of the malignant melanomas a 50% increase in the CDDP dose did not compensate for the reduced antitumor activity caused by the high NaCl concentration in the vehicle.""?",False, +25963723,Sodium Chloride causes cardiac arrest,1927,Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.,"Is the triple ""Sodium Chloride causes cardiac arrest"" supported by the sentence: ""Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest.""?",False, +24999522,Sodium Chloride causes Nausea,1928,"In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.","Is the triple ""Sodium Chloride causes Nausea"" supported by the sentence: ""In this protocol, we use the taste reactivity (TR) test to characterize the hedonic responses of rats to flavors paired with either lithium chloride-induced nausea or internal pain produced by hypertonic NaCl, two treatments that reduce voluntary consumption.""?",False, +23507574,Sodium Chloride causes burn,1929,"The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.","Is the triple ""Sodium Chloride causes burn"" supported by the sentence: ""The results showed that, even at 20 mM NaCl, salinity stress exerted a dominant effect on rhizosphere biogeochemistry and physiological processes, inducing leaf-edge burns, chlorosis/necrosis, reducing vegetative growth in crops; at >=40 mM, NaCl mortality was induced in strawberry.""?",False, +21365055,Sodium Chloride causes respiratory failure,1930,Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.,"Is the triple ""Sodium Chloride causes respiratory failure"" supported by the sentence: ""Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.""?",False, +20716492,Sodium Chloride causes multiple organ dysfunction syndrome,1931,"Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.","Is the triple ""Sodium Chloride causes multiple organ dysfunction syndrome"" supported by the sentence: ""Treatment of H6TPA with In3+ salt does indeed lead to a layered porous MOF, i.e.In-TPA.""?",False, +20666627,Sodium Chloride causes malaria,1932,"During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.","Is the triple ""Sodium Chloride causes malaria"" supported by the sentence: ""During these exposed periods, we observed an approximately threefold increase in CO2 efflux from the marsh as a result of elevated salinity.""?",False, +20168868,Sodium Chloride causes fibromyalgia,1933,"Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.","Is the triple ""Sodium Chloride causes fibromyalgia"" supported by the sentence: ""Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-alpha levels in plasma, muscles, and DRG.""?",False, +19652731,Sodium Chloride causes Chronic pain,1934,"METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.","Is the triple ""Sodium Chloride causes Chronic pain"" supported by the sentence: ""METHODS: After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength.""?",False, +19581650,Sodium Chloride causes neoplasm,1935,"NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.","Is the triple ""Sodium Chloride causes neoplasm"" supported by the sentence: ""NaHCO3 significantly increased the induction of neoplastic and preneoplastic lesions of the urinary bladder, whereas NaCl did not.""?",False, +19527177,Sodium Chloride causes liver and intrahepatic bile duct neoplasm,1936,"Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.","Is the triple ""Sodium Chloride causes liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice.""?",False, +19434783,Sodium Chloride causes Low back pain,1937,"METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).","Is the triple ""Sodium Chloride causes Low back pain"" supported by the sentence: ""METHODS: In 19 healthy participants, the trunk muscle activity during 20 multi-directional unpredictable surface perturbations were recorded after bilateral isotonic saline injections (control) and during unilateral and bilateral hypertonic saline-induced low back pain (LBP) in conditions of back muscle fatigue (Day-1) and DOMS (Day-2).""?",False, +19352698,Sodium Chloride causes bone fracture,1938,"Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.","Is the triple ""Sodium Chloride causes bone fracture"" supported by the sentence: ""Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives.""?",False, +19268574,Sodium Chloride causes ulcerative colitis,1939,"Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.","Is the triple ""Sodium Chloride causes ulcerative colitis"" supported by the sentence: ""Altogether, these results suggest that Lentinus edodes betaGs could inhibit the DSS-induced ulcerative colitis and decrease inflammatory factor expressions.""?",False, +18873789,Sodium Chloride causes preeclampsia,1940,This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.,"Is the triple ""Sodium Chloride causes preeclampsia"" supported by the sentence: ""This hypothesis also offers new insights about the role of salt in the etiology of miscarriage and preeclampsia.""?",False, +18760766,Sodium Chloride causes heart disorder,1941,"Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.","Is the triple ""Sodium Chloride causes heart disorder"" supported by the sentence: ""Sodium chloride is an important ingredient added to most of foods which contributes to flavor enhancement and food preservation but excess intake of sodium chloride may also cause various diseases such as heart diseases, osteoporosis and so on.""?",False, +18419412,Sodium Chloride causes infertility disorder,1942,"The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.","Is the triple ""Sodium Chloride causes infertility disorder"" supported by the sentence: ""The use of H. mediterranei as the producing strain avoids the need for strict sterility due to the culture's high salinity requirements and, also, allows for polymer extraction by simply contacting the biomass with water.""?",False, +18184755,Sodium Chloride causes intervertebral disc degenerative disorder,1943,"Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.","Is the triple ""Sodium Chloride causes intervertebral disc degenerative disorder"" supported by the sentence: ""Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan.""?",False, +18174270,Sodium Chloride causes asthma,1944,"We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.","Is the triple ""Sodium Chloride causes asthma"" supported by the sentence: ""We conclude that the bronchoconstriction in asthma provoked by inhaled hypertonic saline is mediated predominantly through the hyperosmolar release of histamine from airway mast cells, with a minor contribution being made by prostanoids.""?",False, +17957169,Sodium Chloride causes subarachnoid hemorrhage,1945,Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.,"Is the triple ""Sodium Chloride causes subarachnoid hemorrhage"" supported by the sentence: ""Dipyrone (N.=20) or 0.9% NaCl (N.=20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly.""?",False, +17846702,Sodium Chloride causes cardiovascular disorder,1946,"Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.","Is the triple ""Sodium Chloride causes cardiovascular disorder"" supported by the sentence: ""Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.""?",False, +17472790,Sodium Chloride causes Postoperative Complications,1947,"BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.","Is the triple ""Sodium Chloride causes Postoperative Complications"" supported by the sentence: ""BACKGROUND: Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications.""?",False, +17050802,Sodium Chloride causes pulmonary arterial hypertension,1948,Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.,"Is the triple ""Sodium Chloride causes pulmonary arterial hypertension"" supported by the sentence: ""Our results showed that excess salt induced pulmonary hypertension (indicated by higher mPAP) and right ventricular hypertrophy (greater ascites heart index) in broiler chickens.""?",False, +16922792,Sodium Chloride causes aortic aneurysm,1949,"CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.","Is the triple ""Sodium Chloride causes aortic aneurysm"" supported by the sentence: ""CONCLUSIONS: The current study describes a novel aortic aneurysm animal model induced by mineralocorticoid receptor agonist and high salt, and reveals a previously unrecognized but potentially significant role of aldosterone in the pathogenesis of aortic aneurysm.""?",False, +16902385,Sodium Chloride causes Hypoxemia,1950,The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.,"Is the triple ""Sodium Chloride causes Hypoxemia"" supported by the sentence: ""The results suggest that rapid saline infusion in man can cause interstitial edema and lead to premature airway closure and hypoxemia.""?",False, +16884655,Sodium Chloride causes obesity disorder,1951,[Promoting obesity with the salt shaker. How too much salt causes obesity in children].,"Is the triple ""Sodium Chloride causes obesity disorder"" supported by the sentence: ""[Promoting obesity with the salt shaker. How too much salt causes obesity in children].""?",False, +15862216,Sodium Chloride causes Sepsis,1952,"In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.","Is the triple ""Sodium Chloride causes Sepsis"" supported by the sentence: ""In catheterized conscious rats, ETOH or saline infusion was started 24 hours before the induction of sepsis, and continued throughout the experiment.""?",False, +15183436,Sodium Chloride causes cardiac rhythm disease,1953,"CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""","Is the triple ""Sodium Chloride causes cardiac rhythm disease"" supported by the sentence: ""CONCLUSIONS: Small volumes of 7.5% NaCl led to fewer arrhythmias and a 2.6 times survival benefit over untreated rats, and a partial resuscitation of MAP into the ""permissive range.""""?",False, +14507617,Sodium Chloride causes brain edema,1954,"The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.","Is the triple ""Sodium Chloride causes brain edema"" supported by the sentence: ""The marked and non-uniform alterations in factors of water-salt metabolism and of the vascular tone regulation are important components in the pathogenesis of brain edema, which determines goal-oriented approaches to the search of agents for the treatment of the pathology under consideration.""?",False, +14335740,Sodium Chloride causes essential hypertension,1955,"Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.","Is the triple ""Sodium Chloride causes essential hypertension"" supported by the sentence: ""Recent work, however, has provided further evidence that the current dietary intake of salt in Western societies is an important factor in the genesis of essential hypertension and may even partly cause blood pressure-independent target organ damage including renal damage.""?",False, +14100671,Sodium Chloride causes Cough,1956,"Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.","Is the triple ""Sodium Chloride causes Cough"" supported by the sentence: ""Ethanol (3%, 10 min) inhalation, that per se did not cause any tussive response, significantly increased the number of coughs evoked by RTX inhalation without affecting hypertonic saline (7%) induced cough.""?",False, +13899816,Sodium Chloride causes brain injury,1957,BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.,"Is the triple ""Sodium Chloride causes brain injury"" supported by the sentence: ""BACKGROUND AND PURPOSE: The precise mechanism of salt-induced brain injury is unclear.""?",False, +13415978,Sodium Chloride causes rhinitis,1958,Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).,"Is the triple ""Sodium Chloride causes rhinitis"" supported by the sentence: ""Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).""?",False, +13156241,Sodium Chloride causes allergic disease,1959,"The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.","Is the triple ""Sodium Chloride causes allergic disease"" supported by the sentence: ""The stop1 mutation resulted in no effects on cadmium, copper, lanthanum, manganese and sodium chloride sensitivitities, whereas it caused hypersensitivity to Al(3+) rhizotoxicity.""?",False, +12922926,Sodium Chloride causes periodontitis,1960,"Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.","Is the triple ""Sodium Chloride causes periodontitis"" supported by the sentence: ""Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day.""?",False, +12796728,Sodium Chloride causes myocardial infarction,1961,"Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.","Is the triple ""Sodium Chloride causes myocardial infarction"" supported by the sentence: ""Phosphate-buffered saline (PBS), 5x10(5) CD34+ cells/kg, 5x10(5) tMNCs/kg (low-dose MNCs [loMNCs]), or a higher dose of tMNCs (hiMNCs) containing 5x10(5) CD34+ cells/kg was transplanted intramyocardially 10 minutes after the induction of MI in athymic nude rats.""?",False, +12757253,Sodium Chloride causes urticaria,1962,"If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.","Is the triple ""Sodium Chloride causes urticaria"" supported by the sentence: ""If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive.""?",False, +12052924,Sodium Chloride causes Fever,1963,"Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.","Is the triple ""Sodium Chloride causes Fever"" supported by the sentence: ""Trehalose biosynthesis observed with NaCl plus high temperature (40 degrees C) indicated that its production was specifically triggered by NaCl, not temperature.""?",False, +11367442,Sodium Chloride causes Hypothermia,1964,"In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.","Is the triple ""Sodium Chloride causes Hypothermia"" supported by the sentence: ""In conclusion, a local cerebral hypothermia induced by local saline infusion prior to reperfusion produced a long-term functional recovery after ischemic stroke.""?",False, +10844905,Sodium Chloride causes kidney disorder,1965,These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.,"Is the triple ""Sodium Chloride causes kidney disorder"" supported by the sentence: ""These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.""?",False, +10703852,Sodium Chloride causes Ascites,1966,Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.,"Is the triple ""Sodium Chloride causes Ascites"" supported by the sentence: ""Material obtained from the in vitro incubation of granulocytes from saline-induced peritoneal exudates of rabbits has been shown to produce inflammation and fever in rabbits.""?",False, +10680402,Sodium Chloride causes kidney failure,1967,[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].,"Is the triple ""Sodium Chloride causes kidney failure"" supported by the sentence: ""[FUNCTIONAL RENAL INSUFFICIENCIES DUE TO WATER AND SALT DISORDERS].""?",False, +10468869,Sodium Chloride causes Hyperhidrosis,1968,The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.,"Is the triple ""Sodium Chloride causes Hyperhidrosis"" supported by the sentence: ""The properties of the receptors in the axon reflex sweating produced by nicotine and sodium chloride.""?",False, +10303736,Sodium Chloride causes Hemorrhage,1969,Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.,"Is the triple ""Sodium Chloride causes Hemorrhage"" supported by the sentence: ""Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals.""?",False, +10216492,Sodium Chloride causes Insulin resistance,1970,"What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.","Is the triple ""Sodium Chloride causes Insulin resistance"" supported by the sentence: ""What's more, increased oxidative stress appears to be crucially involved in both AII- and high-salt-induced insulin resistance.""?",False, +9649854,Sodium Chloride causes Inflammation,1971,Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.,"Is the triple ""Sodium Chloride causes Inflammation"" supported by the sentence: ""Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted.""?",False, +9417058,Sodium Chloride causes stroke disorder,1972,"The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.","Is the triple ""Sodium Chloride causes stroke disorder"" supported by the sentence: ""The results of this study show that meals given by mass catering institutions can increase risk of hypertension, strokes and gastric cancers because of high sodium chloride content.""?",False, +9370401,Sodium Chloride causes acute kidney failure,1973,"RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.","Is the triple ""Sodium Chloride causes acute kidney failure"" supported by the sentence: ""RESULTS: Acute renal failure in our patients was predominantly due to salt and fluid depletion, and sepsis.""?",False, +9311776,Sodium Chloride causes hypotensive disorder,1974,Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.,"Is the triple ""Sodium Chloride causes hypotensive disorder"" supported by the sentence: ""Control rats received intraperitoneal (i.p.) injections of 0.5 ml saline immediately after SAH before hypotension induction and after 60 min of occlusion.""?",False, +8912328,Sodium Chloride causes injury,1975,"Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.","Is the triple ""Sodium Chloride causes injury"" supported by the sentence: ""Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation.""?",False, +8760965,Sodium Chloride causes hyperinsulinism,1976,"Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).","Is the triple ""Sodium Chloride causes hyperinsulinism"" supported by the sentence: ""Male Sprague-Dawley rats were injected daily with dexamethasone (2 mg/kg for 12 days), which resulted in hyperinsulinemia and hyperglycemia compared with controls (which were injected with sodium chloride).""?",False, +8723767,Sodium Chloride causes Hyponatremia,1977,"The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.","Is the triple ""Sodium Chloride causes Hyponatremia"" supported by the sentence: ""The critical difference between SIADH and CSW is that CSW involves renal salt loss leading to hyponatremia and volume loss, whereas SIADH is a euvolemic or hypervolemic condition.""?",False, +8658207,Sodium Chloride causes ischemic disease,1978,"Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.","Is the triple ""Sodium Chloride causes ischemic disease"" supported by the sentence: ""Selegiline (0.5 mg/kg, SC) or 0.9% NaCl was administered once a day, beginning on the second day after induction of ischemia and continuing for 30 days.""?",False, +8215909,Sodium Chloride causes type 2 diabetes mellitus,1979,"The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.","Is the triple ""Sodium Chloride causes type 2 diabetes mellitus"" supported by the sentence: ""The aims of this study were to develop a rat model of combined NaCl-induced hypertension and NIDD, and to determine the contribution of the sympathetic nervous system to the development of the manifest hypertension.""?",False, +7966995,Sodium Chloride causes Shock,1980,"In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.","Is the triple ""Sodium Chloride causes Shock"" supported by the sentence: ""In this study the response of S. mutans H7 to acid shock was compared with the responses generated by salt, heat, oxidation and starvation.""?",False, +7871886,Sodium Chloride causes Hypernatremia,1981,"Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').","Is the triple ""Sodium Chloride causes Hypernatremia"" supported by the sentence: ""Diuretic adaptations can be classified as those that occur during diuretic action, those that cause sodium retention in the short term (causing 'post-diuretic NaCl retention'), and those that increase sodium retention chronically (the 'braking phenomenon').""?",False, +7769838,Sodium Chloride causes Pain,1982,The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.,"Is the triple ""Sodium Chloride causes Pain"" supported by the sentence: ""The saline infusion caused local pain defined as pain located around the injection site and referred pain areas not included in the local pain area.""?",False, +7535626,Sodium Chloride causes pulmonary edema,1983,"The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.","Is the triple ""Sodium Chloride causes pulmonary edema"" supported by the sentence: ""The injection of 4 microL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence.""?",False, +7170398,Sodium Chloride causes cataract,1984,"Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.","Is the triple ""Sodium Chloride causes cataract"" supported by the sentence: ""Experimental data indicate that the pirenoxine sodium salt and U74389F may be considered effective tools for rejecting an oxidative attack on the lenses, which can finally lead to cataract formation.""?",False, +7067270,Sodium Chloride causes hypertensive disorder,1985,"The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.","Is the triple ""Sodium Chloride causes hypertensive disorder"" supported by the sentence: ""The remaining lipid fractions were within normal ranges or a little decreased in salt-induced hypertension, while in renal and adrenal-regeneration hypertension their quantity was significantly increased.""?",False, +27640062,Sodium Chloride affects hyperinsulinism,1986,Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.,"Is the triple ""Sodium Chloride affects hyperinsulinism"" supported by the sentence: ""Studies in humans have suggested that hyperinsulinemia might play an important role in salt sensitivity and in the later development of high blood pressure.""?",False, +27459630,Sodium Chloride affects ischemic disease,1987,"In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.","Is the triple ""Sodium Chloride affects ischemic disease"" supported by the sentence: ""In the non-PC groups, those with CEC (3 mg/kg, n = 7), 5-MU (3 mg/kg, n = 7), BN (0.3 mg/kg, n = 7), POB (4 mg/kg, n = 7), or placebo saline (n = 10) were pretreated before 30-min sustained ischemia.""?",False, +26883243,Sodium Chloride affects pulmonary edema,1988,"The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.","Is the triple ""Sodium Chloride affects pulmonary edema"" supported by the sentence: ""The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan.""?",False, +25873721,Sodium Chloride affects stroke disorder,1989,Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].,"Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""Effect of NaCl on cerebral stroke and cerebrovascular atherogenesis in rats [proceedings].""?",False, +25698961,Sodium Chloride affects Hypovolemia,1990,"However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.","Is the triple ""Sodium Chloride affects Hypovolemia"" supported by the sentence: ""However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration.""?",False, +23350231,Sodium Chloride affects allergic disease,1991,"Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""Moreover, among eight cationic salts tested, NaCl was selective to enhance the detection sensitivity of the system, resulting in the reduction of C LOD to 0.10 MUM.""?",False, +21279163,Sodium Chloride affects Postoperative Nausea and Vomiting,1992,Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride affects Postoperative Nausea and Vomiting"" supported by the sentence: ""Objective: To observe the effects of intravenous granisetron and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chloride on postoperative nausea and vomiting (PONV) after gynecological laparoscopic surgery.""?",False, +19916489,Sodium Chloride affects malaria,1993,"The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""The sampling sites followed a north to south gradient of increasing salinity, decreasing urban influence, and increasing marsh cover.""?",False, +19654566,Sodium Chloride affects Fever,1994,The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.,"Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The antioxidant responses such as superoxide dismutase and catalase were significantly increased by the high temperature and decreased by the low salinity.""?",False, +19387644,Sodium Chloride affects Dyspnea,1995,The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.,"Is the triple ""Sodium Chloride affects Dyspnea"" supported by the sentence: ""The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.""?",False, +19198162,Sodium Chloride affects Hyperhidrosis,1996,"ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively.""?",False, +19068195,Sodium Chloride affects Pain,1997,RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.,"Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""RESULTS: Hypertonic saline infusion increased perceived pain (4/10cm on a VAS; P<.05) and altered right knee angle (more flexion and less abduction; P<.05) and internal net joint torque (less extension and greater abduction; P<.05) across various stance phases.""?",False, +18857149,Sodium Chloride affects injury,1998,We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy.""?",False, +18063112,Sodium Chloride affects myocardial infarction,1999,Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.,"Is the triple ""Sodium Chloride affects myocardial infarction"" supported by the sentence: ""Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.""?",False, +17981225,Sodium Chloride affects Fever,2000,"The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""The novel strains differed from them by higher growth temperature, sensitivity to NaCl concentration above 3.0 % and by their cellular fatty acids profile.""?",False, +17956116,Sodium Chloride affects Hyponatremia,2001,Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.,"Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Normal saline forms the mainstay of treatment for hypovolemic hyponatremia while 3% NaCl and fluid restriction are important for euvolemic hyponatremia.""?",False, +17749046,Sodium Chloride affects asthma,2002,The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma.""?",False, +17453252,Sodium Chloride affects Hyperhidrosis,2003,"The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.","Is the triple ""Sodium Chloride affects Hyperhidrosis"" supported by the sentence: ""The data raise a possibility that either the NaCl or Na+-K+-2Cl- co-transport system or both may be involved in MCH-induced sweat secretion, whereas the role of parallel ion exchangers, if any, may be rather minor.""?",False, +17320603,Sodium Chloride affects brain injury,2004,"STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""STUDY DESIGN: Seven-day-old Wistar rats were divided into two groups, one receiving a 0.1 mg/kg dose of carbachol on days 7, 8 and 9 to examine the attenuating effect on brain damage with decreasing accumulation of microglia, and the other group receiving saline as a control.""?",False, +17252322,Sodium Chloride affects iron deficiency anemia,2005,"At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.","Is the triple ""Sodium Chloride affects iron deficiency anemia"" supported by the sentence: ""At the end of the experiment, the fronds of inoculum treated with 200 mM NaCl showed the chlorotic effect, higher glutamate dehydrogenase (NADH-GDH) activity and lower GS activity.""?",False, +17081119,Sodium Chloride affects cataract,2006,PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride affects cataract"" supported by the sentence: ""PURPOSE: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.""?",False, +17021361,Sodium Chloride affects urticaria,2007,"CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.","Is the triple ""Sodium Chloride affects urticaria"" supported by the sentence: ""CONCLUSIONS AND CLINICAL IMPORTANCE: Percutaneous application of 6 mg/mL glycerinated histamine solution, 50% glycerosaline solution and 0.9% buffered saline produced similar positive and negative control wheals.""?",False, +16829226,Sodium Chloride affects osteoarthritis,2008,"The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.","Is the triple ""Sodium Chloride affects osteoarthritis"" supported by the sentence: ""The microscale frictional coefficient mu of human cartilage in phosphate-buffered saline increased with increasing osteoarthritis stages, resulting in mu = 0.119 +/- 0.036 for stage 0 (normal cartilage), 0.151 +/- 0.039 for stage I, 0.158 +/- 0.041 for stage 2, and 0.409 +/- 0.119 for stage 3.""?",False, +16392979,Sodium Chloride affects Sepsis,2009,Effects of hydrogen-rich saline treatment on polymicrobial sepsis.,"Is the triple ""Sodium Chloride affects Sepsis"" supported by the sentence: ""Effects of hydrogen-rich saline treatment on polymicrobial sepsis.""?",False, +16339812,Sodium Chloride affects Inflammation,2010,OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.,"Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""OBJECTIVE: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity.""?",False, +16191401,Sodium Chloride affects Shock,2011,"When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.","Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""When exposed to NaCl shocks for 12h, the sludge retention time (SRT) of the reactor decreased with increasing NaCl shock loads, ranging between 2.9 and 22.5d, meanwhile the biomass decreased by 0.8-37.4%.""?",False, +16150899,Sodium Chloride affects severe cutaneous adverse reaction,2012,Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.,"Is the triple ""Sodium Chloride affects severe cutaneous adverse reaction"" supported by the sentence: ""Sodium morrhuate and phosphate-buffered saline demonstrated no difference in their ability to augment tendon adhesion scar formation.""?",False, +15784044,Sodium Chloride affects Electrolytes,2013,From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.,"Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""From the calorimetric titrations the differences in sign and magnitude of enthalpy change upon addition of various electrolytes were observed depending on the salt used.""?",False, +15684126,Sodium Chloride affects malaria,2014,"Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.","Is the triple ""Sodium Chloride affects malaria"" supported by the sentence: ""Phragmites australis is spreading into North American coastal marshes that are experiencing reduced salinities, while Spartina spp. are spreading into northern European brackish marshes that are experiencing increased salinities as land use patterns change on the two continents.""?",False, +15518572,Sodium Chloride affects ischemia reperfusion injury,2015,This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.,"Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats.""?",False, +15358630,Sodium Chloride affects brain injury,2016,"Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.","Is the triple ""Sodium Chloride affects brain injury"" supported by the sentence: ""Interestingly, the application of PBS and G-CSF in the acute phase increased brain damage in the hippocampus.""?",False, +14974493,Sodium Chloride affects cardiovascular disorder,2017,"OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.","Is the triple ""Sodium Chloride affects cardiovascular disorder"" supported by the sentence: ""OBJECTIVE: To provide a current overview of the worldwide prevalence and pattern of cardiovascular disease and discuss the role of sodium intake and salt sensitivity, with a focus on the Asian Indian population.""?",False, +14875621,Sodium Chloride affects Hypoxemia,2018,"CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.","Is the triple ""Sodium Chloride affects Hypoxemia"" supported by the sentence: ""CONCLUSION: Both Radix Morindae of drying product and salt product can enhance anti-hypoxia and reproductive system of mice, and the effect of the salt product was superior to the drying product.""?",False, +14652078,Sodium Chloride affects preeclampsia,2019,Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.,"Is the triple ""Sodium Chloride affects preeclampsia"" supported by the sentence: ""Experiments to determine the effect of furnishing an ample supply of sodium chloride on the toxemia of pyloric and intestinal obstruction are reported.""?",False, +14650670,Sodium Chloride affects Ascites,2020,In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series.""?",False, +14454543,Sodium Chloride affects Inflammation,2021,"Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.","Is the triple ""Sodium Chloride affects Inflammation"" supported by the sentence: ""Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.""?",False, +14269847,Sodium Chloride affects kidney disorder,2022,"Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.","Is the triple ""Sodium Chloride affects kidney disorder"" supported by the sentence: ""Effective control of glycaemia, blood pressure, cholesterol and triglycerides, use of ACE inhibitors, dietary interventions with protein and salt restriction, smoking cessation, can delay the progression of nephropathy in type 2 diabetes.""?",False, +13713189,Sodium Chloride affects acute lung injury,2023,Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.,"Is the triple ""Sodium Chloride affects acute lung injury"" supported by the sentence: ""Acute lung injury effects of the pulmonary delivery of gemcitabine were performed in Sprague-Dawley rats after i.t.o. and i.v. administration of gemcitabine and i.t.o. administration of lipopolysaccharide (LPS) as a positive control and physiological saline as a blank control.""?",False, +13361928,Sodium Chloride affects cardiac rhythm disease,2024,"This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.","Is the triple ""Sodium Chloride affects cardiac rhythm disease"" supported by the sentence: ""This should be an ideal profile for calcium regulators against Na(+)(i)-related diseases, such as ischemia/reperfusion injuries, salt-dependent hypertension, and digitalis arrhythmia.""?",False, +13091031,Sodium Chloride affects ischemia reperfusion injury,2025,"Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.","Is the triple ""Sodium Chloride affects ischemia reperfusion injury"" supported by the sentence: ""Interestingly, benzyloxyphenyl NCX inhibitors effectively prevent several ischemia-reperfusion injuries and salt-dependent hypertension in animal models.""?",False, +12113298,Sodium Chloride affects diabetes mellitus,2026,"The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.","Is the triple ""Sodium Chloride affects diabetes mellitus"" supported by the sentence: ""The main barrier to guideline implementation is possibly the inadequate treatment of extracellular volume expansion despite the large prevalence of factors, such as older age and diabetes, which further enhance the intrinsic BP salt sensitivity of CKD.""?",False, +11936868,Sodium Chloride affects allergic disease,2027,"In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.","Is the triple ""Sodium Chloride affects allergic disease"" supported by the sentence: ""In comparison with wild-type plants, 35S:AtERF4-GFP transgenic plants had decreased sensitivity to ABA and were hypersensitive to sodium chloride.""?",False, +11761266,Sodium Chloride affects stroke disorder,2028,"CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.","Is the triple ""Sodium Chloride affects stroke disorder"" supported by the sentence: ""CONCLUSIONS: Excess salt, via oxidative stress, accelerates stroke, and angiotensin II, via AT1 receptor, plays a pivotal role in brain superoxide production of SHRSP by excess salt.""?",False, +11373059,Sodium Chloride affects Pain,2029,"In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.","Is the triple ""Sodium Chloride affects Pain"" supported by the sentence: ""In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration.""?",False, +11352407,Sodium Chloride affects hypotensive disorder,2030,"Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.","Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively.""?",False, +10762234,Sodium Chloride affects hypotensive disorder,2031,[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].,"Is the triple ""Sodium Chloride affects hypotensive disorder"" supported by the sentence: ""[Pressor effects of ammonium metavanadate in the dog subjected to the action of a sympathicolytic and influence of this salt on the hypotension which adrenalin then induces normally in that animal].""?",False, +10689150,Sodium Chloride affects Hemorrhage,2032,"The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""The increased blood loss resulted from: 1, increased vascular pressure and vasodilatation (total peripheral resistance index -27 +/- 5 percent, p<0.05), as initial bleeding occurred when MAP and cardiac index are increased compared with the control group (+88 +/- 10 percent, p<0.05 and +82 +/- 7 percent, p<0.01, respectively) and as the concomitant infusion of angiotensin II, a potent vasoconstrictor, delayed the HTS-induced bleeding (resumed at 60 minutes), and 2, a defect in platelet aggregation reflected by decreased adenosine diphosphate (ADP)-induced maximal aggregation (-79 percent versus rats treated with 0.9 percent NaCl, p<0.05) and increased EC50 of ADP (+159 percent, p<0.05).""?",False, +10555492,Sodium Chloride affects nutritional disorder,2033,[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].,"Is the triple ""Sodium Chloride affects nutritional disorder"" supported by the sentence: ""[Relations of essential hypertension to sodium chloride (table salt). IV. Clinical and animal experimental studies on the effects of nutritional deficiency and subsequent artificial feeding on hypertensive disease].""?",False, +10543207,Sodium Chloride affects myocarditis,2034,"Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.","Is the triple ""Sodium Chloride affects myocarditis"" supported by the sentence: ""Infected animals given either 100 or 1000 micrograms of this preparation for 2 days prior to infection showed greater than 50% reduction in myocarditis compared to control animals which were infected and given either phosphate buffered saline, human immunoglobulin or monoclonal mouse IgG to an extraneous antigen.""?",False, +10409590,Sodium Chloride affects essential hypertension,2035,"The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.","Is the triple ""Sodium Chloride affects essential hypertension"" supported by the sentence: ""The importance of tubulointerstitial injury in the pathophysiology of human essential hypertension, and particularly salt sensitivity, is increasingly recognized.""?",False, +10373089,Sodium Chloride affects Hypernatremia,2036,"Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.","Is the triple ""Sodium Chloride affects Hypernatremia"" supported by the sentence: ""Because the infusion of sodium bicarbonate resulted in hypernatremia, the effect of hypernatremia was studied in an additional group that received hypertonic saline.""?",False, +10347664,Sodium Chloride affects neoplasm,2037,"However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.","Is the triple ""Sodium Chloride affects neoplasm"" supported by the sentence: ""However, lower acetic acid concentrations in saturated NaCl produced greater tumor coagulation, suggesting that, in this hypovascular tumor model, alterations in electrical conductivity play a more important role in increasing tumor ablation efficiency than do the additional ablative effects of acetic acid.""?",False, +10303742,Sodium Chloride affects Hemorrhage,2038,"In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.","Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""In a model of uncontrolled hemorrhage induced by complete splenic laceration with a hilar vascular injury, we hypothesized that small-volume hypertonic saline or large-volume lactated Ringer's solution may provide sustained hemodynamic benefits despite promoting increases in intra-abdominal bleeding.""?",False, +10216887,Sodium Chloride affects Shock,2039,Refolding of a high molecular weight protein: salt effect on collapse.,"Is the triple ""Sodium Chloride affects Shock"" supported by the sentence: ""Refolding of a high molecular weight protein: salt effect on collapse.""?",False, +10038950,Sodium Chloride affects injury,2040,This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.,"Is the triple ""Sodium Chloride affects injury"" supported by the sentence: ""This study tested the hypothesis that administration of intratracheal aerosolized HTS modulates the development of lung injury in pancreatitis.""?",False, +9833746,Sodium Chloride affects obesity disorder,2041,"Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.","Is the triple ""Sodium Chloride affects obesity disorder"" supported by the sentence: ""Epidemiological studies have shown an association between MA and insulin resistance, obesity, salt sensitivity and dyslipidaemia in patients with essential hypertension and diabetes.""?",False, +9701968,Sodium Chloride affects brain edema,2042,The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.,"Is the triple ""Sodium Chloride affects brain edema"" supported by the sentence: ""The effects of continuous HS infusion in brain tumor-associated edema have not been previously reported.""?",False, +9235049,Sodium Chloride affects Hyponatremia,2043,"Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.","Is the triple ""Sodium Chloride affects Hyponatremia"" supported by the sentence: ""Thirteen-month-old SHHF/Mcc-fa(cp) rats were pretreated for 72 h before experiments with furosemide (100 mg/kg by gavage 72, 48, and 24 h before experiments) to mimic the clinical setting of chronic diuretic therapy and were given 1% NaCl as drinking water to reduce dehydration/sodium depletion.""?",False, +9211629,Sodium Chloride affects asthma,2044,OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.,"Is the triple ""Sodium Chloride affects asthma"" supported by the sentence: ""OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma.""?",False, +8885675,Sodium Chloride affects Ascites,2045,The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.,"Is the triple ""Sodium Chloride affects Ascites"" supported by the sentence: ""The effects of elevated levels of sodium chloride on ascites and related problems in turkeys.""?",False, +8142503,Sodium Chloride affects Insulin resistance,2046,"These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.","Is the triple ""Sodium Chloride affects Insulin resistance"" supported by the sentence: ""These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.""?",False, +7538296,Sodium Chloride affects depressive disorder,2047,"Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Glutamate-induced LTD, as well as the HFS-induced LTD, was blocked by L-sulpiride, a D2 DA receptor antagonist, and by 7-nitroindazole monosodium salt, a NO synthase inhibitor.""?",False, +7487288,Sodium Chloride affects Hemorrhage,2048,Epinephrine in bupivacaine or saline reduced peroperative bleeding.,"Is the triple ""Sodium Chloride affects Hemorrhage"" supported by the sentence: ""Epinephrine in bupivacaine or saline reduced peroperative bleeding.""?",False, +7249676,Sodium Chloride affects Fever,2049,"By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.","Is the triple ""Sodium Chloride affects Fever"" supported by the sentence: ""By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures.""?",False, +7189372,Sodium Chloride affects depressive disorder,2050,"Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.","Is the triple ""Sodium Chloride affects depressive disorder"" supported by the sentence: ""Nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) and 7-nitroindazole monosodium salt (7-NINA) block LTD induced by either HFS or zaprinast, but not that induced by cGMP.""?",False, +7186849,Sodium Chloride affects hypertensive disorder,2051,"Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.","Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""Hypertension in blacks is characterized by salt sensitivity, a tendency towards expanded plasma volume and low plasma renin levels.""?",False, +7146026,Sodium Chloride affects hypertensive disorder,2052,This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.,"Is the triple ""Sodium Chloride affects hypertensive disorder"" supported by the sentence: ""This finding may be of use in future studies directed at identifying genotypes associated with salt-dependent hypertension.""?",False, +10370500,Sodium Chloride affects Electrolytes,2053,"As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.","Is the triple ""Sodium Chloride affects Electrolytes"" supported by the sentence: ""As the indifferent electrolyte concentration is increased from low values (<5 mM), the zeta-potential and droplet size, estimated from the dynamic mobility by the normal procedures, gradually increase in magnitude until the size plateaus and the zeta-potential begins to decrease with added salt in the usual fashion.""?",False, +14010559,Sodium Chloride produces hypertensive disorder,2054,Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.,"Is the triple ""Sodium Chloride produces hypertensive disorder"" supported by the sentence: ""Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.""?",False, +25864505,Sodium Chloride disrupts malaria,2055,A trial of chloroquine-medicated salt for malaria suppression in Uganda.,"Is the triple ""Sodium Chloride disrupts malaria"" supported by the sentence: ""A trial of chloroquine-medicated salt for malaria suppression in Uganda.""?",False, +19817939,Sodium Chloride disrupts chronic obstructive pulmonary disease,2056,Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.,"Is the triple ""Sodium Chloride disrupts chronic obstructive pulmonary disease"" supported by the sentence: ""Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.""?",False, +19569177,Sodium Chloride disrupts anxiety,2057,Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.,"Is the triple ""Sodium Chloride disrupts anxiety"" supported by the sentence: ""Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.""?",False, +19347835,Sodium Chloride disrupts cardiac rhythm disease,2058,Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.,"Is the triple ""Sodium Chloride disrupts cardiac rhythm disease"" supported by the sentence: ""Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.""?",False, +19339201,Sodium Chloride disrupts Cough,2059,"On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.","Is the triple ""Sodium Chloride disrupts Cough"" supported by the sentence: ""On days 4-20, the CA and CA+DEX groups were exposed to CA, and the SA group to saline thrice weekly, during which the CA+DEX group was administered DEX pretreatment to inhibit cough.""?",False, +18711875,Sodium Chloride disrupts pulmonary edema,2060,"Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.","Is the triple ""Sodium Chloride disrupts pulmonary edema"" supported by the sentence: ""Compared with the PBS infusion, the BMSC infusion significantly preserved lung function, reduced lung edema and pulmonary microvascular permeability, and decreased the total injury score in rats with IRI.""?",False, +18638520,Sodium Chloride disrupts brain edema,2061,TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.,"Is the triple ""Sodium Chloride disrupts brain edema"" supported by the sentence: ""TBI-rhEpo and TBI-Cepo groups had a reduced brain edema compared with TBI-saline.""?",False, +18394970,Sodium Chloride disrupts Inflammation,2062,"In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.","Is the triple ""Sodium Chloride disrupts Inflammation"" supported by the sentence: ""In conclusion, HS may inhibit inflammation in EBI and improve neurobehavioral outcome after SAH, partially via inactivation of NF-kappaB pathway and NLRP3 inflammasome.""?",False, +17319016,Sodium Chloride disrupts dental caries,2063,"Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.","Is the triple ""Sodium Chloride disrupts dental caries"" supported by the sentence: ""Studies initiated in the early seventies showed that fluoride, when added to salt, inhibits dental caries.""?",False, +17223012,Sodium Chloride disrupts hypertensive disorder,2064,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts hypertensive disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, +17223011,Sodium Chloride disrupts cardiovascular disorder,2065,[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.,"Is the triple ""Sodium Chloride disrupts cardiovascular disorder"" supported by the sentence: ""[Scientific statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases.""?",False, +17009512,Sodium Chloride disrupts allergic disease,2066,"Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.","Is the triple ""Sodium Chloride disrupts allergic disease"" supported by the sentence: ""Generally, both mutants displayed a suppression of the hypersensitivity of abh1 to ABA, NaCl and mannitol during germination.""?",False, +13585452,Sodium Chloride disrupts neoplasm,2067,"Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.","Is the triple ""Sodium Chloride disrupts neoplasm"" supported by the sentence: ""Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3.""?",False, +12586414,Sodium Chloride disrupts Hypoxemia,2068,"Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.","Is the triple ""Sodium Chloride disrupts Hypoxemia"" supported by the sentence: ""Incorporating perftoran and ozonized isotonic solution of sodium chloride in conventionally accepted complex impedes the tissue hypoxia occurrence, which starts after biliary system decompression, it promotes restoration of hepatic cells functional state in more early terms.""?",False, +12214170,Sodium Chloride disrupts injury,2069,"Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.","Is the triple ""Sodium Chloride disrupts injury"" supported by the sentence: ""Hyperosmolar NaCl and urea also suppress lytic injury mediated by ammonia and complement in MDCK, a cell line derived from canine distal tubular epithelium.""?",False, +10927798,Sodium Chloride disrupts stroke disorder,2070,"The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.","Is the triple ""Sodium Chloride disrupts stroke disorder"" supported by the sentence: ""The selective P2Y1 R antagonist, 2'deoxy-N6-methyl adenosine 3',5'-diphosphate diammonium salt, reduced stroking (54%) and 2MeSADP (70%) responses at P2Y1 Rs.""?",False, +8273399,Sodium Chloride disrupts Pain,2071,Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.,"Is the triple ""Sodium Chloride disrupts Pain"" supported by the sentence: ""Both interpleural bupivacaine and saline significantly reduced pain scores 30 min after the administration.""?",False, +27207716,Sodium Chloride prevents periodontal disorder,2072,"Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.","Is the triple ""Sodium Chloride prevents periodontal disorder"" supported by the sentence: ""Most of the mothers were aware of the importance of toothbrushing, but 33% also recommended the use of salt for prevention of periodontal disease.""?",False, +27075073,Sodium Chloride prevents subarachnoid hemorrhage,2073,"The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.","Is the triple ""Sodium Chloride prevents subarachnoid hemorrhage"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of oral treatment with the endothelin (ET) A/B receptor antagonist Ro 47-0203, 4-tert-butyl-N-[6-(hydroxy- ethoxy)-5-(2-methoxy-phenoxy)-2'-bipyrimidin-4-yl]-benzenesulfonam ide (bosentan), and the ET A receptor antagonist 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy- phenyl)-4-oxo-but-2-enoic acid monosodium salt (PD155080), in the prevention of subarachnoid hemorrhage (SAH)-induced delayed cerebral vasospasm.""?",False, +23771600,Sodium Chloride prevents sinusitis,2074,Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.,"Is the triple ""Sodium Chloride prevents sinusitis"" supported by the sentence: ""Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.""?",False, +21279166,Sodium Chloride prevents Postoperative Nausea and Vomiting,2075,Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.,"Is the triple ""Sodium Chloride prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""Conclusion: Either intravenous granisetron or acupuncture point injection at PC6 of 0.9% sodium chloride can effectively reduce the incidence of postoperative nausea and vomiting after gynecological laparoscopic surgery.""?",False, +20586429,Sodium Chloride prevents stroke disorder,2076,"In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).","Is the triple ""Sodium Chloride prevents stroke disorder"" supported by the sentence: ""In SHRSP given 1% NaCl in their drinking water, a diet containing 10% active fibre (powdered brown seaweed converted to K+ form) significantly lowered blood pressure (BP) and markedly reduced the incidence of stroke (0 versus 100% in controls on the 30th day of experiment).""?",False, +20472317,Sodium Chloride prevents myocardial infarction,2077,This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.,"Is the triple ""Sodium Chloride prevents myocardial infarction"" supported by the sentence: ""This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms.""?",False, +20150308,Sodium Chloride prevents Chronic pain,2078,"Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.","Is the triple ""Sodium Chloride prevents Chronic pain"" supported by the sentence: ""Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.""?",False, +20050861,Sodium Chloride prevents Dyspnea,2079,DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.,"Is the triple ""Sodium Chloride prevents Dyspnea"" supported by the sentence: ""DISCUSSION: Our study showed superiority of dosimetrically administered nebulized morphine compared to NaCl in reducing breathlessness.""?",False, +19622277,Sodium Chloride prevents Pruritus,2080,"IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).","Is the triple ""Sodium Chloride prevents Pruritus"" supported by the sentence: ""IV pentazocine reduced the overall incidence of pruritus within the first 24 hours compared to IV saline, with an estimated relative risk of 69% (95% confidence interval [CI], 52%, 90%; P = .007).""?",False, +19347836,Sodium Chloride prevents cardiac rhythm disease,2081,"Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.","Is the triple ""Sodium Chloride prevents cardiac rhythm disease"" supported by the sentence: ""Among all the hypertonic solutions tested, only 7.5% NaCl effectively protected against conduction disturbances and cardiac arrhythmias.""?",False, +18643598,Sodium Chloride prevents ventricular tachycardia,2082,"Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.","Is the triple ""Sodium Chloride prevents ventricular tachycardia"" supported by the sentence: ""Furthermore, Sema3a overexpression in the LSG reduced the incidence of inducible ventricular tachyarrhythmia by programmed electrical stimulation post-MI, and arrhythmia scores were significantly lower in the AdSema3a group than in the PBS and AdGFP groups.""?",False, +18145237,Sodium Chloride prevents Nausea,2083,The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).,"Is the triple ""Sodium Chloride prevents Nausea"" supported by the sentence: ""The aim of this randomized prospective double-blind trial was to assess whether installation of isotonic saline can reduce postoperative pain and nausea following laparoscopic cholecystectomy (LC).""?",False, +17285701,Sodium Chloride prevents neuralgia,2084,"In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).","Is the triple ""Sodium Chloride prevents neuralgia"" supported by the sentence: ""In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI).""?",False, +17081118,Sodium Chloride prevents cataract,2085,CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.,"Is the triple ""Sodium Chloride prevents cataract"" supported by the sentence: ""CONCLUSIONS: This is an initial report showing that hydrogen saline can prevent selenite-induced cataract in rats.""?",False, +16603496,Sodium Chloride prevents brain injury,2086,DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.,"Is the triple ""Sodium Chloride prevents brain injury"" supported by the sentence: ""DISCUSSION: The results indicate that H(2) rich saline prevents immune-mediated brain injury after CO poisoning.""?",False, +16427621,Sodium Chloride prevents diabetes mellitus,2087,"Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.","Is the triple ""Sodium Chloride prevents diabetes mellitus"" supported by the sentence: ""Adding to meal the powder of plant's rhizome Curcuma longa contributes to the restoration of the morphological structure of the liver, kidney, the normalization of water-salt and carbohydrate metabolism, this can be used in programs for integrated prevention of diabetes in areas of technological risk.""?",False, +16310359,Sodium Chloride prevents burn,2088,CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.,"Is the triple ""Sodium Chloride prevents burn"" supported by the sentence: ""CONCLUSIONS: Sonographically guided radiofrequency ablation with a saline injection superficial to a tumor might prevent skin burns and provide equivalent therapeutic efficacy for ablating superficial lesions.""?",False, +16010295,Sodium Chloride prevents ischemic disease,2089,These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.,"Is the triple ""Sodium Chloride prevents ischemic disease"" supported by the sentence: ""These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia.""?",False, +15507954,Sodium Chloride prevents pulmonary arterial hypertension,2090,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.","Is the triple ""Sodium Chloride prevents pulmonary arterial hypertension"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.""?",False, +15307837,Sodium Chloride prevents acute lung injury,2091,"In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.","Is the triple ""Sodium Chloride prevents acute lung injury"" supported by the sentence: ""In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.""?",False, +15219283,Sodium Chloride prevents allergic disease,2092,"KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.","Is the triple ""Sodium Chloride prevents allergic disease"" supported by the sentence: ""KEY RESULTS: Administration of APETx2 into the gastrocnemius muscle prior to the administration of low pH saline prevented the development of mechanical hypersensitivity, whereas APETx2 administration following low-pH saline was ineffective in reversing hypersensitivity.""?",False, +14919203,Sodium Chloride prevents spinal cord injury,2093,Hydrogen-rich saline protects against spinal cord injury in rats.,"Is the triple ""Sodium Chloride prevents spinal cord injury"" supported by the sentence: ""Hydrogen-rich saline protects against spinal cord injury in rats.""?",False, +14359710,Sodium Chloride prevents obesity disorder,2094,"METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.","Is the triple ""Sodium Chloride prevents obesity disorder"" supported by the sentence: ""METHODS: Six individual interventions (treatment of hypertension, hypercholesterolemia, smoking cessation and combined clinical strategies to reduce the 10 year CVD Risk) and two population-based interventions (cooperation between government, consumer associations and bakery chambers to reduce salt in bread, and mass education strategies to reduce hypertension, hypercholesterolemia and obesity) were selected for analysis.""?",False, +14313516,Sodium Chloride prevents Inflammation,2095,"In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.","Is the triple ""Sodium Chloride prevents Inflammation"" supported by the sentence: ""In conclusion, hydrogen-rich saline protected the small intestine against I/R injury, possibly by reduction of inflammation and oxidative stress.""?",False, +14313515,Sodium Chloride prevents ischemia reperfusion injury,2096,Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.,"Is the triple ""Sodium Chloride prevents ischemia reperfusion injury"" supported by the sentence: ""Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.""?",False, +13297854,Sodium Chloride prevents kidney disorder,2097,"In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.","Is the triple ""Sodium Chloride prevents kidney disorder"" supported by the sentence: ""In conclusion, hydration with sodium bicarbonate is more effective than with sodium chloride for the prevention of contrast-induced nephropathy in patients undergoing an emergency coronary procedure.""?",False, +12464836,Sodium Chloride prevents malaria,2098,"The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.","Is the triple ""Sodium Chloride prevents malaria"" supported by the sentence: ""The intercellular CO(2) concentrations increased with increasing salinity in the inland population, but decreased in the marsh (tolerant) population.""?",False, +12453134,Sodium Chloride prevents iron deficiency anemia,2099,Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).,"Is the triple ""Sodium Chloride prevents iron deficiency anemia"" supported by the sentence: ""Anabaena cylindrica grown with nitrate required higher levels of sodium (0.4 meq/l NaCl) to prevent chlorosis than when grown without combined nitrogen (0.004 meq/l NaCl).""?",False, +12276610,Sodium Chloride prevents essential hypertension,2100,The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.,"Is the triple ""Sodium Chloride prevents essential hypertension"" supported by the sentence: ""The main clinical implication of the thermoregulatory-vascular remodeling hypothesis is that avoiding the ingestion of sodium chloride is the key to preventing essential hypertension.""?",False, +12092501,Sodium Chloride prevents hypertensive disorder,2101,"Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.","Is the triple ""Sodium Chloride prevents hypertensive disorder"" supported by the sentence: ""Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats.""?",False, +11205687,Sodium Chloride prevents acute kidney failure,2102,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Chloride prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, +10429352,Sodium Chloride prevents injury,2103,"Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.","Is the triple ""Sodium Chloride prevents injury"" supported by the sentence: ""Comparative efficiency of ethylene glycol, glucose and sodium chloride in protecting tissues against freezing injury.""?",False, +10205494,Sodium Chloride prevents Hypovolemia,2104,"Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.","Is the triple ""Sodium Chloride prevents Hypovolemia"" supported by the sentence: ""Rats had free access to 0.9% NaCl, 0.1%KCl solution to prevent volume depletion.""?",False, +9628485,Sodium Chloride prevents anemia,2105,The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.,"Is the triple ""Sodium Chloride prevents anemia"" supported by the sentence: ""The double fortification of salt with both iodine and iron is an attractive approach to the reduction of both anemia and iodine-deficiency disorders.""?",False, +8227059,Sodium Chloride prevents Shock,2106,The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.,"Is the triple ""Sodium Chloride prevents Shock"" supported by the sentence: ""The open lung group underwent six saline lavages at different ventilator settings that prevented alveolar collapse.""?",False, +8196581,Sodium Chloride prevents dental caries,2107,Fluorinated salt was added to rations of preschool children for preventing dental caries.,"Is the triple ""Sodium Chloride prevents dental caries"" supported by the sentence: ""Fluorinated salt was added to rations of preschool children for preventing dental caries.""?",False, +8059428,Sodium Chloride prevents Pain,2108,"RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.","Is the triple ""Sodium Chloride prevents Pain"" supported by the sentence: ""RESULTS: Non-steroidal anti-inflammatory drugs, wound local anaesthetic, intraperitoneal local anaesthetic, intraperitoneal saline, a gas drain, heated gas, low-pressure gas and nitrous oxide pneumo-peritoneum have been shown to reduce pain after LC.""?",False, +22103068,Sodium Chloride exacerbates hypertensive disorder,2109,The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.,"Is the triple ""Sodium Chloride exacerbates hypertensive disorder"" supported by the sentence: ""The failure of nephritic rats to respond to DOCA/NaCl by increasing UKE was not associated with any significant derangement of renal function or structure and may have been related to the aggravation of arterial hypertension in this group.""?",False, +20308305,Sodium Chloride exacerbates Inflammation,2110,"NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.","Is the triple ""Sodium Chloride exacerbates Inflammation"" supported by the sentence: ""NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase.""?",False, +21816011,Sodium Chloride predisposes essential hypertension,2111,"This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.","Is the triple ""Sodium Chloride predisposes essential hypertension"" supported by the sentence: ""This large study confirms longitudinally the importance of obesity, weight gain during adulthood, alcohol, family history, and, to some extent, salt as predictive and possibly causal factors for essential hypertension.""?",False, +19774957,Sodium Chloride predisposes pulmonary edema,2112,"Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.","Is the triple ""Sodium Chloride predisposes pulmonary edema"" supported by the sentence: ""Vigorous fluid replacement with hypotonic saline and parenteral narcotic analgesics are conventional modalities of therapy, but may contribute to the development of pulmonary edema.""?",False, +18380691,Sodium Chloride predisposes myocardial infarction,2113,"Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.","Is the triple ""Sodium Chloride predisposes myocardial infarction"" supported by the sentence: ""Decreased transcription of agrA, ami, gadC, and opuC in both strains was promoted by low NaCl content.""?",False, +18041213,Sodium Chloride predisposes Inflammation,2114,The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.,"Is the triple ""Sodium Chloride predisposes Inflammation"" supported by the sentence: ""The studies on mice have revealed that sodium chloride plays a role in the modulation of the immune system and a high-salt diet can promote tissue inflammation and autoimmune disease.""?",False, +16033022,Sodium Chloride predisposes injury,2115,"In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.","Is the triple ""Sodium Chloride predisposes injury"" supported by the sentence: ""In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice.""?",False, +13840593,Sodium Chloride predisposes allergic disease,2116,IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.,"Is the triple ""Sodium Chloride predisposes allergic disease"" supported by the sentence: ""IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction.""?",False, +13808663,Sodium Chloride predisposes diabetes mellitus,2117,"Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.","Is the triple ""Sodium Chloride predisposes diabetes mellitus"" supported by the sentence: ""Patients with smell impairment are reported to use larger quantities of sugar and salt to highlight flavours, thus worsening their general health condition and increasing the risk of developing diabetes and hypertension.""?",False, +13731023,Sodium Chloride predisposes cardiovascular disorder,2118,It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.,"Is the triple ""Sodium Chloride predisposes cardiovascular disorder"" supported by the sentence: ""It is well known that excessive intake of sodium chloride (sodium) is a risk factor for cardiovascular disease because it raises blood pressure.""?",False, +12280034,Sodium Chloride predisposes neoplasm,2119,"The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.","Is the triple ""Sodium Chloride predisposes neoplasm"" supported by the sentence: ""The present results demonstrate that whereas tumors in the glandular stomach and forestomach are both promoted by NaCl, ethanol is without influence.""?",False, +12079247,Sodium Chloride predisposes hypertensive disorder,2120,"Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.","Is the triple ""Sodium Chloride predisposes hypertensive disorder"" supported by the sentence: ""Chronic nitric oxide (NO) inhibition and salt overload (HS) promote severe hypertension and renal injury, which regress quickly, although not completely, on treatment withdrawal.""?",False, +11776631,Sodium Chloride predisposes stroke disorder,2121,"These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.","Is the triple ""Sodium Chloride predisposes stroke disorder"" supported by the sentence: ""These data are consistent with the hypothesis that a high intake of salt may increase the risk of stroke, independent of effects on blood pressure.""?",False, +11266800,Sodium Chloride predisposes kidney disorder,2122,"The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.","Is the triple ""Sodium Chloride predisposes kidney disorder"" supported by the sentence: ""The indications for coronary angiography are the same for patients with CKD as for the general population, but patients with CKD are at greatly increased risk for contrast-associated nephropathy, the least controversial preventive therapy, which consists of isotonic saline and N-acetylcysteine.""?",False, +10118531,Sodium Chloride predisposes obesity disorder,2123,"To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).","Is the triple ""Sodium Chloride predisposes obesity disorder"" supported by the sentence: ""To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed a lithogenic diet (15% dairy fat, 1.25% cholesterol, 0.5% cholic acid).""?",False, +9111875,Sodium Chloride predisposes cardiac rhythm disease,2124,"Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).","Is the triple ""Sodium Chloride predisposes cardiac rhythm disease"" supported by the sentence: ""Examples of these sequelae are the development of myocardial and vascular fibrosis in uninephrectomized, salt-loaded rats infused with mineralocorticoids and, in humans, an association of aldosterone with left ventricular hypertrophy, impaired diastolic and systolic function, salt and water retention causing aggravation of congestion in patients with established congestive cardiac failure (CCF), reduced vascular compliance and an increased risk of arrhythmias (resulting from intracardiac fibrosis, hypokalaemia, hypomagnesaemia, reduced baroreceptor sensitivity and potentiation of catecholamine effects).""?",False, +9647073,Dexpanthenol related to skin disorder,2125,Topical use of dexpanthenol in skin disorders.,"Is the triple ""Dexpanthenol related to skin disorder"" supported by the sentence: ""Topical use of dexpanthenol in skin disorders.""?",False, +26305399,Dexpanthenol affects Erythema,2126,"Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.","Is the triple ""Dexpanthenol affects Erythema"" supported by the sentence: ""Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation.""?",False, +25421467,Dexpanthenol prevents cheilitis,2127,OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.,"Is the triple ""Dexpanthenol prevents cheilitis"" supported by the sentence: ""OBJECTIVES: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.""?",False, +24024712,ELTROMBOPAG related to autoimmune thrombocytopenic purpura,2128,"CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.","Is the triple ""ELTROMBOPAG related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""CONCLUSION: Eltrombopag is a salvage drug, used in refractory ITP.""?",False, +22097814,ELTROMBOPAG related to acute myeloid leukemia,2129,A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.,"Is the triple ""ELTROMBOPAG related to acute myeloid leukemia"" supported by the sentence: ""A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.""?",False, +22063304,ELTROMBOPAG related to aplastic anemia,2130,The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.,"Is the triple ""ELTROMBOPAG related to aplastic anemia"" supported by the sentence: ""The safety profile was consistent with previous EPAG studies in AA; no patients discontinued drug due to adverse events.""?",False, +22063303,ELTROMBOPAG related to myelodysplastic syndrome,2131,We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.,"Is the triple ""ELTROMBOPAG related to myelodysplastic syndrome"" supported by the sentence: ""We conducted a phase 2 dose modification study to investigate the safety and efficacy of EPAG in LR-MDS.""?",False, +22049758,ELTROMBOPAG related to thrombocytopenia,2132,"Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.","Is the triple ""ELTROMBOPAG related to thrombocytopenia"" supported by the sentence: ""Although prospective evidence of the efficacy is limited, there are increasing reports on the safety and efficacy with Eltrombopag in post HSCT thrombocytopenia and poor graft function.""?",False, +23835836,ELTROMBOPAG causes anemia,2133,This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.,"Is the triple ""ELTROMBOPAG causes anemia"" supported by the sentence: ""This is the first report on eltrombopag-induced AIHA in the management of WM-associated ITP.""?",False, +22601227,ELTROMBOPAG affects thrombocytopenia,2134,The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.""?",False, +21709185,ELTROMBOPAG affects thrombocytopenia,2135,We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.,"Is the triple ""ELTROMBOPAG affects thrombocytopenia"" supported by the sentence: ""We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT.""?",False, +22821304,ELTROMBOPAG prevents Hemorrhage,2136,"Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.","Is the triple ""ELTROMBOPAG prevents Hemorrhage"" supported by the sentence: ""Conclusions: Thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag were effective in reducing bleeding events, especially grade >=3 bleeding events.""?",False, +22169266,ELTROMBOPAG prevents thrombocytopenia,2137,We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.,"Is the triple ""ELTROMBOPAG prevents thrombocytopenia"" supported by the sentence: ""We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer.""?",False, +12546229,Etamsylate affects Hemorrhage,2138,"Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.","Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Of these, well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia.""?",False, +9791897,Etamsylate affects Hemorrhage,2139,Effect of Etamsylate on menstrual blood loss in women using IUDs.,"Is the triple ""Etamsylate affects Hemorrhage"" supported by the sentence: ""Effect of Etamsylate on menstrual blood loss in women using IUDs.""?",False, +22608563,Etamsylate prevents Hemorrhage,2140,Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.,"Is the triple ""Etamsylate prevents Hemorrhage"" supported by the sentence: ""Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial.""?",False, +26536250,mitomycin C related to Deoxyribonucleic acid,2141,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, +26536250,mitomycin C related to Deoxyribonucleic acid,2142,"pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.","Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""pBR322 DNA methylated by CpG-methylase was cross-linked two- to three-times more efficiently by MC than non-methylated DNA, indicating that the m5C effect is not an artifact of oligonucleotides.""?",False, +26158944,mitomycin C related to adenocarcinoma,2143,"Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.","Is the triple ""mitomycin C related to adenocarcinoma"" supported by the sentence: ""Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas.""?",False, +26111339,mitomycin C related to squamous cell carcinoma,2144,"Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.","Is the triple ""mitomycin C related to squamous cell carcinoma"" supported by the sentence: ""Phase II study of mitomycin-C, vincristine, and bleomycin in advanced squamous cell carcinoma of the uterine cervix.""?",False, +26043076,mitomycin C related to neoplasm,2145,"The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.","Is the triple ""mitomycin C related to neoplasm"" supported by the sentence: ""The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse.""?",False, +25722815,mitomycin C related to leukemia,2146,"Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.","Is the triple ""mitomycin C related to leukemia"" supported by the sentence: ""Calcium channel blockers also potentiate the antitumor activities of several DNA-interacting drugs, such as adriamycin, THP-adriamycin, daunomycin, aclacinomycin A, mitomycin C, actinomycin D, mitoxantrone, and nogalamycin derivatives in P388 leukemia resistant to adriamycin.""?",False, +12722759,mitomycin C related to carcinoma,2147,"Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.","Is the triple ""mitomycin C related to carcinoma"" supported by the sentence: ""Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region.""?",False, +10467532,mitomycin C related to non-small cell lung carcinoma,2148,"A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.","Is the triple ""mitomycin C related to non-small cell lung carcinoma"" supported by the sentence: ""A randomized prospective study of cisplatin and vinblastine versus cisplatin, vinblastine and mitomycin in advanced non-small cell lung cancer.""?",False, +7255625,mitomycin C related to Deoxyribonucleic acid,2149,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, +7255625,mitomycin C related to Deoxyribonucleic acid,2150,Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.,"Is the triple ""mitomycin C related to Deoxyribonucleic acid"" supported by the sentence: ""Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.""?",False, +8689799,mitomycin C coexists with Deoxyribonucleic acid,2151,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, +8689799,mitomycin C coexists with Deoxyribonucleic acid,2152,"Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.","Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Cells harvested from Fanconi anemia (FA) patients show an increased hypersensitivity to the multifunctional DNA damaging agent mitomycin C (MMC), which causes cross-links in DNA as well as 7,8-dihydro-8-oxoguanine (8-oxoG) adducts indicative of escalated oxidative DNA damage.""?",False, +8030161,mitomycin C coexists with Deoxyribonucleic acid,2153,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, +8030161,mitomycin C coexists with Deoxyribonucleic acid,2154,Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.,"Is the triple ""mitomycin C coexists with Deoxyribonucleic acid"" supported by the sentence: ""Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-nick end-labeling (TUNEL) assay revealed that the combination of MMC with UCN-01 increased DNA breaks consistent with apoptosis in p53 defective A431 epidermoid carcinoma cells.""?",False, +7255626,mitomycin C physically interacts with Deoxyribonucleic acid,2155,"Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.","Is the triple ""mitomycin C physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Reductive activation of MC is necessary for drug covalent binding to DNA, and we have found that some potential-controlled interactions of MC with DNA occur at the electrode, i.e.""?",False, +25769130,mitomycin C causes sarcoma,2156,"Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.","Is the triple ""mitomycin C causes sarcoma"" supported by the sentence: ""Subcutaneous sarcomas induced by mitomycin C in mice: comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin S and 3-methylcholanthrene.""?",False, +25692678,mitomycin C causes hepatocellular carcinoma,2157,The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.,"Is the triple ""mitomycin C causes hepatocellular carcinoma"" supported by the sentence: ""The effects of reduction surgery combined with chemotherapy used by MMC and ADM for DAB induced hepatoma were investigated.""?",False, +20975852,mitomycin C causes carcinoma,2158,CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.,"Is the triple ""mitomycin C causes carcinoma"" supported by the sentence: ""CONCLUSION: The combination of MTC with CHAM-NE could be valuable in enhancing the therapeutic efficacy of MTC against EAC and in eliminating MTC-induced hepatotoxicity.""?",False, +12184177,mitomycin C causes Corneal opacity,2159,"When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.","Is the triple ""mitomycin C causes Corneal opacity"" supported by the sentence: ""When applied immediately after PRK, MMC induced corneal opacity and apoptosis of keratocytes, but, at later times, this reagent significantly suppressed opacity, Apostain-positive keratocytes and reactivation of keratocytes, even after UVB irradiation.""?",False, +11626710,mitomycin C causes urethral stricture,2160,Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.,"Is the triple ""mitomycin C causes urethral stricture"" supported by the sentence: ""Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.""?",False, +9485346,mitomycin C causes neoplasm,2161,The influence of mitomycin C on the induction of crown-gall tumors.,"Is the triple ""mitomycin C causes neoplasm"" supported by the sentence: ""The influence of mitomycin C on the induction of crown-gall tumors.""?",False, +26017044,mitomycin C affects squamous cell carcinoma,2162,Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.,"Is the triple ""mitomycin C affects squamous cell carcinoma"" supported by the sentence: ""Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.""?",False, +25924198,mitomycin C affects adenocarcinoma,2163,Effect of mitomycin-C on McCall rat colon adenocarcinoma.,"Is the triple ""mitomycin C affects adenocarcinoma"" supported by the sentence: ""Effect of mitomycin-C on McCall rat colon adenocarcinoma.""?",False, +24961205,mitomycin C affects neoplasm,2164,"CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSION: Adding MMC to the regimen of nCCRT for rectal adenocarcinoma is shown to increase tumor down-staging rate and improve disease-free and OS, although these benefits come at the cost of increased low-grade toxicities.""?",False, +21183193,mitomycin C affects transitional cell carcinoma,2165,Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.,"Is the triple ""mitomycin C affects transitional cell carcinoma"" supported by the sentence: ""Conclusion: The mannan-mitomycin C conjugate has greater inhibitory and apoptotic effects on TCC than on L929 cells and may inhibit TCC.""?",False, +20995393,mitomycin C affects urinary bladder neoplasm,2166,"Instillation of MMC markedly increased the development of bladder tumors, although CA did not.","Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""Instillation of MMC markedly increased the development of bladder tumors, although CA did not.""?",False, +20865956,mitomycin C affects pterygium,2167,Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.,"Is the triple ""mitomycin C affects pterygium"" supported by the sentence: ""Evaluation of antimitotic and antiangiogenic effect of preoperative subconjunctival application of mitomycin C in primary pterygium: a randomized trial.""?",False, +17166086,mitomycin C affects mesothelioma,2168,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""mitomycin C affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, +15342296,mitomycin C affects sclerosing cholangitis,2169,Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.,"Is the triple ""mitomycin C affects sclerosing cholangitis"" supported by the sentence: ""Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.""?",False, +14897135,mitomycin C affects Corneal opacity,2170,PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.,"Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.""?",False, +14480408,mitomycin C affects liver and intrahepatic bile duct neoplasm,2171,"The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.","Is the triple ""mitomycin C affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The antitumor effect of rhEndostatin in combination with several chemotherapeutic drugs, e.g., 5-fluorouracil, cyclophosphamide, methotrexate, and mitomycin C, on human QGY liver tumor and mice H22 liver tumor was compared with that of rhEndostatin treatment alone.""?",False, +14435862,mitomycin C affects Corneal opacity,2172,"Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.","Is the triple ""mitomycin C affects Corneal opacity"" supported by the sentence: ""Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that reduces the myofibroblast repopulation after laser surface ablation and, therefore, reduces the risk of postoperative corneal haze.""?",False, +10146530,mitomycin C affects open-angle glaucoma,2173,A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.,"Is the triple ""mitomycin C affects open-angle glaucoma"" supported by the sentence: ""A comparison of the intraocular pressure-lowering effect and safety of viscocanalostomy and trabeculectomy with mitomycin C in bilateral open-angle glaucoma.""?",False, +8885108,mitomycin C affects urinary bladder neoplasm,2174,These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.,"Is the triple ""mitomycin C affects urinary bladder neoplasm"" supported by the sentence: ""These data indicate that the sensitivity of patient bladder tumors to MMC is correlated with the expression of DTD and P450R in tumors and suggest that the lower expression of these enzymes in the high-grade and more invasive tumors is a cause of the lower efficacy of intravesical MMC in these tumors.""?",False, +8612675,mitomycin C affects Deoxyribonucleic acid,2175,It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.,"Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""It is probably inactivated by a single MMC-induced deoxyribonucleic acid cross-link per genome.""?",False, +8242643,mitomycin C affects neoplasm,2176,"CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.","Is the triple ""mitomycin C affects neoplasm"" supported by the sentence: ""CONCLUSIONS: NQO1 was detected by immunohistochemistry in every examined section of corneal and conjunctival epithelial dysplasia and neoplasia, suggesting that NQO1 may play a role in the bioactivation of mitomycin C in these tumors.""?",False, +8428809,mitomycin C affects Deoxyribonucleic acid,2177,"DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.","Is the triple ""mitomycin C affects Deoxyribonucleic acid"" supported by the sentence: ""DNAs from cells treated with increasing doses of mitomycin were proportionately more effective in competition for repressor, suggesting increasing binding sites per unit of DNA.""?",False, +26926271,mitomycin C disrupts Neoplasm Metastasis,2178,"When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.","Is the triple ""mitomycin C disrupts Neoplasm Metastasis"" supported by the sentence: ""When the antitumor activities of 5-FU and MMC against PANC-4 were determined in vivo using the nude mouse orthotopic transplant treatment model, slight local tumor growth inhibition with equivalent incidence of metastases to the liver and the peritoneum as the control were observed in the mice treated with 5-FU, while those treated with MMC had considerably reduced local tumor growth without liver and peritoneal metastases.""?",False, +21172443,mitomycin C disrupts urinary bladder neoplasm,2179,"However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.","Is the triple ""mitomycin C disrupts urinary bladder neoplasm"" supported by the sentence: ""However, the intermittent instillation of high concentrated MMC hardly inhibited the development of bladder tumors.""?",False, +16608751,mitomycin C disrupts carcinoma,2180,RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.,"Is the triple ""mitomycin C disrupts carcinoma"" supported by the sentence: ""RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.""?",False, +12093037,mitomycin C disrupts neoplasm,2181,"As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.","Is the triple ""mitomycin C disrupts neoplasm"" supported by the sentence: ""As with other members of this class, it was shown to be 8 to 20 times more potent than mitomycin C (MMC) in cytotoxicity to murine and human tumor cell lines in vitro, in causing DNA cross links in vitro, and in dose levels for tumor inhibition in vivo.""?",False, +8920186,mitomycin C disrupts Corneal opacity,2182,CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.,"Is the triple ""mitomycin C disrupts Corneal opacity"" supported by the sentence: ""CONCLUSION: A single intraoperative application of topical mitomycin C during PRK in rabbits reduced corneal haze by inhibiting the proliferation of keratocytes.""?",False, +22973529,mitomycin C prevents glaucoma,2183,"CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.","Is the triple ""mitomycin C prevents glaucoma"" supported by the sentence: ""CONCLUSION: Among supervised ophthalmology trainees in the Philippines, trab-MMC for PACG was effective in lowering IOP long term and decreasing glaucoma medications, and surgical success rates were generally comparable with trainee studies from first world nations.""?",False, +19902018,mitomycin C prevents keratoconus,2184,Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.,"Is the triple ""mitomycin C prevents keratoconus"" supported by the sentence: ""Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus.""?",False, +19673685,mitomycin C prevents urethral stricture,2185,Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.,"Is the triple ""mitomycin C prevents urethral stricture"" supported by the sentence: ""Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture.""?",False, +12959208,mitomycin C prevents Neoplasm Metastasis,2186,"Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.","Is the triple ""mitomycin C prevents Neoplasm Metastasis"" supported by the sentence: ""Therefore, we consider there are effective doses and/or administration timing of aspirin and MMC to prevent secondary cancer.""?",False, +11642092,mitomycin C prevents Esophageal stenosis,2187,"The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.","Is the triple ""mitomycin C prevents Esophageal stenosis"" supported by the sentence: ""The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.""?",False, +9925117,mitomycin C prevents neoplasm,2188,"An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).","Is the triple ""mitomycin C prevents neoplasm"" supported by the sentence: ""An overall statistically significant superiority of BCG versus mitomycin C efficacy in reducing tumor recurrence was detected (OR 0.56, 95% CI 0.38 to 0.84, p = 0.005).""?",False, +8410588,mitomycin C prevents pterygium,2189,"CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.","Is the triple ""mitomycin C prevents pterygium"" supported by the sentence: ""CONCLUSION: This study showed that amniotic membrane graft was as effective as conjunctival autograft and mitomycin C in preventing pterygium recurrence, and can be considered as a preferred grafting procedure for primary pterygium.""?",False, +7308263,mitomycin C prevents urinary bladder neoplasm,2190,"CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.","Is the triple ""mitomycin C prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSION: A possible clinical application is potentiation of the action of mitomycin C by hyperthermia in the prevention of recurrent superficial bladder tumours, achieving increased efficacy and/or a decreased number of instillations.""?",False, +20886584,mitomycin C predisposes neoplasm,2191,These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.,"Is the triple ""mitomycin C predisposes neoplasm"" supported by the sentence: ""These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.""?",False, +17638153,Cefazolin related to bone fracture,2192,"The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.","Is the triple ""Cefazolin related to bone fracture"" supported by the sentence: ""The increasing prevalence of infection due to gram-negative organisms is treated by combined use of an aminoglycoside with cefazolin, or ceforanide with amikacin, or a third generation cephalosporin in Type III fractures.""?",False, +20958121,Cefazolin causes bacterial infectious disease with sepsis,2193,BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.,"Is the triple ""Cefazolin causes bacterial infectious disease with sepsis"" supported by the sentence: ""BACKGROUND: For patients with bacteraemia caused by methicillin-sensitive Staphylococcus aureus anti-staphylococcal penicillins (ASPs) or cefazolin are agents of choice.""?",False, +25339548,Cefazolin affects obesity disorder,2194,"Overall, cefazolin pharmacokinetics are substantially altered in obesity.","Is the triple ""Cefazolin affects obesity disorder"" supported by the sentence: ""Overall, cefazolin pharmacokinetics are substantially altered in obesity.""?",False, +27670629,Cefazolin prevents staphylococcal infection,2195,PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.,"Is the triple ""Cefazolin prevents staphylococcal infection"" supported by the sentence: ""PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.""?",False, +10537097,Cefazolin prevents bacterial infectious disease,2196,"The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.","Is the triple ""Cefazolin prevents bacterial infectious disease"" supported by the sentence: ""The effect of preoperative intraperitoneal cefazolin, administered at a standard (15 or 30 mg/kg) and high (120 mg/kg) dose, on the prevention of bacterial biofilm infection was studied in a rat model.""?",False, +7415834,Famciclovir affects herpes zoster,2197,"However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.","Is the triple ""Famciclovir affects herpes zoster"" supported by the sentence: ""However, the effects of famciclovir on post-zoster pain were observed in a clinical trial, while those of aciclovir were found only in meta-analyses.""?",False, +27310156,Famciclovir disrupts viral infectious disease,2198,Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.,"Is the triple ""Famciclovir disrupts viral infectious disease"" supported by the sentence: ""Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women.""?",False, +11859744,Famciclovir disrupts herpes simplex infectious disease,2199,OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.,"Is the triple ""Famciclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""OBJECTIVE: The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection.""?",False, +11859743,Famciclovir disrupts genital herpes,2200,Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.,"Is the triple ""Famciclovir disrupts genital herpes"" supported by the sentence: ""Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.""?",False, +7415831,Famciclovir prevents herpes zoster,2201,"In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.","Is the triple ""Famciclovir prevents herpes zoster"" supported by the sentence: ""In this trial famciclovir failed to reduce the incidence of post-zoster pain, but it did reduce its median duration by approximately 2 months.""?",False, +27248580,Acyclovir related to herpes zoster,2202,Effect of acyclovir and prednisolone on the serological response in herpes zoster.,"Is the triple ""Acyclovir related to herpes zoster"" supported by the sentence: ""Effect of acyclovir and prednisolone on the serological response in herpes zoster.""?",False, +20916830,Acyclovir causes viral infectious disease,2203,"Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.","Is the triple ""Acyclovir causes viral infectious disease"" supported by the sentence: ""Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients.""?",False, +21459205,Acyclovir affects herpes zoster,2204,"Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.","Is the triple ""Acyclovir affects herpes zoster"" supported by the sentence: ""Initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acyclovir.""?",False, +17108497,Acyclovir affects genital herpes,2205,In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.,"Is the triple ""Acyclovir affects genital herpes"" supported by the sentence: ""In this report we have examined the effect of acyclovir on ultraviolet radiation-induced recurrent genital herpes.""?",False, +15677184,Acyclovir affects viral infectious disease,2206,The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.,"Is the triple ""Acyclovir affects viral infectious disease"" supported by the sentence: ""The molecular data lend credence to two important aspects of viral pathogenesis: (1) the finding of a homogeneous episomal population in the monoclonal tumors suggests that EBV infection is an early event in tumorigenesis that occurs before clonal expansion; and (2) therapeutic efficacy of acyclovir has been shown only in presence of polyclonal disease but may impact on intermediate stages where linear replicative virus can be found.""?",False, +9966648,Acyclovir affects chickenpox,2207,2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.,"Is the triple ""Acyclovir affects chickenpox"" supported by the sentence: ""2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.""?",False, +8137898,Acyclovir affects cytomegalovirus infection,2208,"In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.","Is the triple ""Acyclovir affects cytomegalovirus infection"" supported by the sentence: ""In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase.""?",False, +26100053,Acyclovir disrupts herpes zoster,2209,"When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.","Is the triple ""Acyclovir disrupts herpes zoster"" supported by the sentence: ""When immunocompromised patients were studied, intravenous acyclovir inhibited the progression of zoster infections and shortened the healing time and duration of viral shedding in patients with cutaneous disseminated zoster.""?",False, +21196251,Acyclovir disrupts cytomegalovirus infection,2210,"METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.","Is the triple ""Acyclovir disrupts cytomegalovirus infection"" supported by the sentence: ""METHODS: Achievement of negative CMV load, using concurrent prophylactic intravenous ganciclovir therapy during induction immunosuppression, combined with a 6-month prophylactic course of acyclovir, would yield a reduced incidence of early CMV infection and disease.""?",False, +21045605,Acyclovir disrupts herpes simplex infectious disease,2211,Bortezomib and acyclovir acted synergistically to inhibit HSV infection.,"Is the triple ""Acyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Bortezomib and acyclovir acted synergistically to inhibit HSV infection.""?",False, +13979845,Acyclovir disrupts HIV infectious disease,2212,"In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.","Is the triple ""Acyclovir disrupts HIV infectious disease"" supported by the sentence: ""In this report, we use a single round HIV infectivity assay to show that acyclovir directly inhibits HIV infection with an IC50 of approximately 5 microm.""?",False, +11163493,Acyclovir disrupts chickenpox,2213,BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.,"Is the triple ""Acyclovir disrupts chickenpox"" supported by the sentence: ""BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.""?",False, +10081763,Acyclovir disrupts viral infectious disease,2214,"Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.","Is the triple ""Acyclovir disrupts viral infectious disease"" supported by the sentence: ""Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14.""?",False, +8112053,Acyclovir disrupts genital herpes,2215,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Acyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, +22220716,Acyclovir prevents chickenpox,2216,Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.,"Is the triple ""Acyclovir prevents chickenpox"" supported by the sentence: ""Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.""?",False, +14453930,Acyclovir prevents herpes zoster,2217,Continuous administration of ACV decreased the incidence of HZ infection.,"Is the triple ""Acyclovir prevents herpes zoster"" supported by the sentence: ""Continuous administration of ACV decreased the incidence of HZ infection.""?",False, +11048138,Acyclovir prevents herpes labialis,2218,The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.,"Is the triple ""Acyclovir prevents herpes labialis"" supported by the sentence: ""The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.""?",False, +10652424,Acyclovir prevents viral infectious disease,2219,The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.,"Is the triple ""Acyclovir prevents viral infectious disease"" supported by the sentence: ""The authors conclude that prophylaxis of herpes simplex virus infection with acyclovir administered orally in the early postoperative period is effective in preventing viral infections during the 1st year after cardiac transplantation.""?",False, +9977810,Acyclovir prevents genital herpes,2220,CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.,"Is the triple ""Acyclovir prevents genital herpes"" supported by the sentence: ""CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.""?",False, +8973083,Acyclovir prevents cytomegalovirus infection,2221,The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.,"Is the triple ""Acyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The clinical efficacy of prophylactic high-dose acyclovir therapy (800 mg qid) was assessed for the prevention of CMV infection and disease in liver recipients.""?",False, +8455850,Acyclovir prevents herpes simplex infectious disease,2222,"HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.","Is the triple ""Acyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported.""?",False, +16777411,Acyclovir predisposes herpes simplex infectious disease,2223,"CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.","Is the triple ""Acyclovir predisposes herpes simplex infectious disease"" supported by the sentence: ""CONCLUSIONS: Canadian pediatric emergency physicians are aware of risk factors for neonatal HSV infection and tailor their history and diagnostic investigations toward the diagnosis of HSV infection, but very few empirically administer acyclovir.""?",False, +14602481,Acyclovir predisposes HIV infectious disease,2224,We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.,"Is the triple ""Acyclovir predisposes HIV infectious disease"" supported by the sentence: ""We concluded that weekly high doses of ACV were able to delay the progression of some significant markers of HIV disease.""?",False, +7066348,Idoxuridine coexists with Deoxyribonucleic acid,2225,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, +7066348,Idoxuridine coexists with Deoxyribonucleic acid,2226,Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.,"Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.""?",False, +10786366,Idoxuridine coexists with Deoxyribonucleic acid,2227,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, +10786366,Idoxuridine coexists with Deoxyribonucleic acid,2228,"RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.","Is the triple ""Idoxuridine coexists with Deoxyribonucleic acid"" supported by the sentence: ""RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs.""?",False, +15969143,Idoxuridine derives from Deoxyribonucleic acid,2229,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, +15969143,Idoxuridine derives from Deoxyribonucleic acid,2230,"In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.","Is the triple ""Idoxuridine derives from Deoxyribonucleic acid"" supported by the sentence: ""In all four cell lines, LV decreased the dehalogenation of IdUrd, producing a 3-fold increase in the labeled iododeoxyuridine triphosphate/dTTP ratios in cytoplasm and labeled IdUrd/thymidine in DNA derived from tritiated IdUrd.""?",False, +10765452,Idoxuridine physically interacts with Deoxyribonucleic acid,2231,Role of MutSalpha in the recognition of iododeoxyuridine in DNA.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Role of MutSalpha in the recognition of iododeoxyuridine in DNA.""?",False, +8193345,Idoxuridine physically interacts with Deoxyribonucleic acid,2232,The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.,"Is the triple ""Idoxuridine physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""The DNA of coliphages T4 and T1 was labelled with 125I-iododeoxyuridine.""?",False, +13332148,Idoxuridine causes viral infectious disease,2233,"Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.","Is the triple ""Idoxuridine causes viral infectious disease"" supported by the sentence: ""Dexamethasone stimulates type C virus production induced by iododeoxyuridine (IdUrd) from several murine cell lines: uninfected BALB cells, virally transformed nonproducer K-BALB cells, mouse neuroblastoma N-4 cells, and rat tumor XC cells.""?",False, +25762983,Idoxuridine affects viral infectious disease,2234,Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.,"Is the triple ""Idoxuridine affects viral infectious disease"" supported by the sentence: ""Activation of a C-type virus from the human carcinoma cell line HBT-3 by iododeoxyuridine and testosterone.""?",False, +25024576,Idoxuridine affects Deoxyribonucleic acid,2235,"Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.","Is the triple ""Idoxuridine affects Deoxyribonucleic acid"" supported by the sentence: ""Furthermore, when the uptake of 125I into DNA is reduced by the addition of nonradioactive IUdR or TdR to the medium and the survival fraction is determined as a function of 125I contained in the DNA, a corresponding increase in survival is observed.""?",False, +25798138,Vidarabine affects herpes simplex infectious disease,2236,Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.,"Is the triple ""Vidarabine affects herpes simplex infectious disease"" supported by the sentence: ""Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.""?",False, +18005400,Ganciclovir related to AIDS,2237,[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].,"Is the triple ""Ganciclovir related to AIDS"" supported by the sentence: ""[Experiences with DHPG (ganciclovir)--treatment of cytomegalovirus retinitis in AIDS].""?",False, +11769089,Ganciclovir related to lymphoma,2238,Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.,"Is the triple ""Ganciclovir related to lymphoma"" supported by the sentence: ""Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells.""?",False, +7813894,Ganciclovir causes hepatocellular carcinoma,2239,"However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.","Is the triple ""Ganciclovir causes hepatocellular carcinoma"" supported by the sentence: ""However, antitumor effects on HCC and tumor immunity to parental HCC induced by the HSV-TK/GCV system were not inferior and even superior to those induced by the CD/5-FC system.""?",False, +21315977,Ganciclovir affects melanoma,2240,"In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.","Is the triple ""Ganciclovir affects melanoma"" supported by the sentence: ""In conclusion, the results demonstrated that curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.""?",False, +18696617,Ganciclovir affects viral infectious disease,2241,"It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.","Is the triple ""Ganciclovir affects viral infectious disease"" supported by the sentence: ""It has been demonstrated as the first report that combination treatment with ganciclovir (GCV) and tricin (4',5,7-trihydroxy-3',5' -dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection has synergistic effects on both infectious virus production and HCMV DNA synthesis in the human embryonic fibroblast cell line MRC-5.""?",False, +14018850,Ganciclovir affects graft versus host disease,2242,OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).,"Is the triple ""Ganciclovir affects graft versus host disease"" supported by the sentence: ""OBJECTIVE: Our aim was to study whether herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated lentiviral gene transfer diminished graft-versus-host disease (GVHD) in a mouse model of allogeneic bone marrow transplantation (BMT).""?",False, +7745805,Ganciclovir affects hepatocellular carcinoma,2243,"Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.","Is the triple ""Ganciclovir affects hepatocellular carcinoma"" supported by the sentence: ""Although the histological examination demonstrated that the efficiency of the gene transfer was less than 30%, the killing effect of HSV-tk/GCV system on hepatocellular carcinoma was still significantly generated.""?",False, +7264703,Ganciclovir affects retinitis,2244,"CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.","Is the triple ""Ganciclovir affects retinitis"" supported by the sentence: ""CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis.""?",False, +7193112,Ganciclovir affects cytomegalovirus retinitis,2245,"Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.","Is the triple ""Ganciclovir affects cytomegalovirus retinitis"" supported by the sentence: ""Factors in the decision to choose the ganciclovir implant include the patient's potential for immunologic improvement, location and severity of CMV retinitis, and the risks and costs associated with implantation and concomitant oral ganciclovir therapy.""?",False, +27515973,Ganciclovir disrupts viral infectious disease,2246,"Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.","Is the triple ""Ganciclovir disrupts viral infectious disease"" supported by the sentence: ""Treatment of UKF-NB-2AD169 cells with ganciclovir, abolishing virus production, reestablished sensitivity to chemotherapy, lowered Bcl-2 expression, and facilitated inducibility of apoptosis to the level of the parental cell line.""?",False, +20042666,Ganciclovir disrupts glioblastoma,2247,"Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.","Is the triple ""Ganciclovir disrupts glioblastoma"" supported by the sentence: ""Particularly, Herpes simplex virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor.""?",False, +11829393,Ganciclovir disrupts cytomegalovirus infection,2248,CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.,"Is the triple ""Ganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSION: Extended prophylaxis with IV and oral ganciclovir practically abolishes cytomegaloviral disease and is related to a decreased incidence of rejection episodes.""?",False, +9242712,Ganciclovir disrupts hepatocellular carcinoma,2249,Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.,"Is the triple ""Ganciclovir disrupts hepatocellular carcinoma"" supported by the sentence: ""Treatment with this viral vector followed by ganciclovir resulted in specific killing of AFP-positive HCC transplanted in nude mice.""?",False, +27273103,Ganciclovir prevents retinitis,2250,"TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.","Is the triple ""Ganciclovir prevents retinitis"" supported by the sentence: ""TREATMENT OF CMV RETINITIS: In patients with detectable CMV, but no evidence of active infection, pre-emptive treatment with ganciclovir or valaciclovir has been shown to reduce the risk of developing retinitis in these high-risk patients.""?",False, +14947813,Ganciclovir prevents viral infectious disease,2251,"This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.","Is the triple ""Ganciclovir prevents viral infectious disease"" supported by the sentence: ""This comprehensive viral monitoring program with defined thresholds for initiation of preemptive GCV effectively prevents the development of critical viral disease, even in high-risk patients receiving ATG.""?",False, +8898867,Ganciclovir prevents cytomegalovirus retinitis,2252,"Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.","Is the triple ""Ganciclovir prevents cytomegalovirus retinitis"" supported by the sentence: ""Similarly, oral ganciclovir reduces the incidence of CMV retinitis; however, there is no definitive data yet for increased survival when used as a prophylaxis.""?",False, +7606615,Ganciclovir prevents cytomegalovirus infection,2253,"Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.","Is the triple ""Ganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""Although several pre-emptive strategies have been shown to be effective in preventing early CMV disease, the ability of pre-emptive strategies using prolonged ganciclovir therapy to reduce the incidence of late-onset CMV infection, disease and mortality has not been fully evaluated.""?",False, +26756507,Nedocromil affects asthma,2254,"As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.","Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""As the frequency or severity of the asthma increases, inhaled corticosteroids, inhaled cromolyn, or inhaled nedocromil should be added to the treatment regimen.""?",False, +12807968,Nedocromil affects asthma,2255,AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.,"Is the triple ""Nedocromil affects asthma"" supported by the sentence: ""AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.""?",False, +15773495,Nedocromil disrupts asthma,2256,Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.,"Is the triple ""Nedocromil disrupts asthma"" supported by the sentence: ""Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.""?",False, +26602335,Nedocromil prevents asthma,2257,Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.,"Is the triple ""Nedocromil prevents asthma"" supported by the sentence: ""Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity.""?",False, +25857910,Flumedroxone related to migraine disorder,2258,"A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.","Is the triple ""Flumedroxone related to migraine disorder"" supported by the sentence: ""A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine.""?",False, +26456255,Valrubicin coexists with Deoxyribonucleic acid,2259,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, +26456255,Valrubicin coexists with Deoxyribonucleic acid,2260,"Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.","Is the triple ""Valrubicin coexists with Deoxyribonucleic acid"" supported by the sentence: ""Despite the absence of this direct interaction, N-trifluoroacetyladriamycin-14-valerate and its metabolites produce alterations in DNA comparable with the effects of intercalating agents.""?",False, +26331358,Valrubicin affects Deoxyribonucleic acid,2261,The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.,"Is the triple ""Valrubicin affects Deoxyribonucleic acid"" supported by the sentence: ""The adriamycin- and N-trifluoroacetyladriamycin-14-valerate (AD-32) induced DNA cross-linking and breakage in human RPMI-6410 cells was compared using the alkaline elution technique of Kohn and co-workers.""?",False, +9013591,Valrubicin affects neoplasm,2262,OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).,"Is the triple ""Valrubicin affects neoplasm"" supported by the sentence: ""OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT).""?",False, +15048973,Valrubicin disrupts neoplasm,2263,Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.,"Is the triple ""Valrubicin disrupts neoplasm"" supported by the sentence: ""Valrubicin significantly inhibited tumor formation in the mouse skin carcinogenesis model and significantly decreased cell viability of the cultured human skin SCC cells.""?",False, +19780799,"Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive",2264,"BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.","Is the triple ""Idarubicin related to blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.""?",False, +19123529,Idarubicin related to acute lymphoblastic leukemia,2265,"A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.","Is the triple ""Idarubicin related to acute lymphoblastic leukemia"" supported by the sentence: ""A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.""?",False, +17160344,Idarubicin related to myelodysplastic syndrome,2266,"Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.","Is the triple ""Idarubicin related to myelodysplastic syndrome"" supported by the sentence: ""Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.""?",False, +13481436,Idarubicin related to acute myeloid leukemia,2267,Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).,"Is the triple ""Idarubicin related to acute myeloid leukemia"" supported by the sentence: ""Recent clinical trials have shown that idarubicin (IDR) in combination with cytosine arabinoside (ARA-C) is more active than daunorubicin at comparable doses in acute myelogenous leukemia (AML).""?",False, +12261572,Idarubicin related to plasma cell myeloma,2268,"High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.","Is the triple ""Idarubicin related to plasma cell myeloma"" supported by the sentence: ""High-dose idarubicin, busulphan and melphalan for autologous stem cell transplantation in multiple myeloma responsive to DAV chemotherapy: comparison with a historical control.""?",False, +10347974,Idarubicin related to non-Hodgkin lymphoma,2269,"Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.","Is the triple ""Idarubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Phase II trial of infusional cyclophosphamide, idarubicin, and etoposide in poor prognosis non-Hodgkin's lymphoma.""?",False, +8798925,Idarubicin related to acute promyelocytic leukemia,2270,Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.,"Is the triple ""Idarubicin related to acute promyelocytic leukemia"" supported by the sentence: ""Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.""?",False, +17955637,Idarubicin causes acute myeloid leukemia,2271,"On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.","Is the triple ""Idarubicin causes acute myeloid leukemia"" supported by the sentence: ""On the basis of these findings, we recommend incorporation of IDA and HDD instead of the traditional CDD as standard treatments for acute myeloid leukaemia induction.""?",False, +10037923,Idarubicin causes neutropenia,2272,The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.,"Is the triple ""Idarubicin causes neutropenia"" supported by the sentence: ""The combined treatment induced a more severe neutropenia with a slower recovery when compared to mice treated with idarubicin alone.""?",False, +27637811,Idarubicin affects acute myeloid leukemia,2273,"In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""In an effort to reduce the relapse rate after unpurged autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), the standard conditioning regimens (cyclophosphamide/busulphan and cyclophosphamide/TBI) were intensified by adding idarubicin.""?",False, +27582612,Idarubicin affects acute lymphoblastic leukemia,2274,The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.,"Is the triple ""Idarubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""The role of idarubicin in adult acute lymphoblastic leukaemia: from drug resistance studies to clinical application.""?",False, +27363552,Idarubicin affects neoplasm,2275,"However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""However, minimizing Cmax, by administration of Ida as prolonged infusion during a 3 day course, might be clinically important in order to reduce cardiotoxicity and hopefully to increase anti-tumor efficacy through an increased accumulation of Ida and IdaOH in leukemic cells.""?",False, +10133635,Idarubicin affects acute myeloid leukemia,2276,"Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.","Is the triple ""Idarubicin affects acute myeloid leukemia"" supported by the sentence: ""Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine.""?",False, +9755321,Idarubicin affects leukemia,2277,"We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.","Is the triple ""Idarubicin affects leukemia"" supported by the sentence: ""We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P388 leukemia resulting in an increase of life span (ILS)=226% in case of MIT+2-CdA and ILS=126% in the case of IDA+2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS=47%.""?",False, +9560678,Idarubicin affects neoplasm,2278,"Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.","Is the triple ""Idarubicin affects neoplasm"" supported by the sentence: ""Evaluating the potential benefit of the new anthracycline, idarubicin (Ida), in lymphoma, 58 tumour samples from patients suffering from low-grade non-Hodgkin's lymphoma (L-NHL), were analysed in vitro for their sensitivity to 0.5 microg/ml Ida.""?",False, +9242996,Idarubicin affects neutropenia,2279,These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.,"Is the triple ""Idarubicin affects neutropenia"" supported by the sentence: ""These results suggest that both IDA and IDAol play an important role in leukocytopenia or neutropenia.""?",False, +18342294,Pirarubicin causes neoplasm,2280,RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.,"Is the triple ""Pirarubicin causes neoplasm"" supported by the sentence: ""RESULTS: SMA-pirarubicin (100 mg/kg) induced ROS exclusively in tumors with minimal levels in serum and cardiac tissue.""?",False, +16182034,Pirarubicin affects neoplasm,2281,Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.,"Is the triple ""Pirarubicin affects neoplasm"" supported by the sentence: ""Influence of coupling bonds on the anti-tumor activity of polymer-pirarubicin conjugates.""?",False, +19153993,Pirarubicin disrupts neoplasm,2282,"As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.","Is the triple ""Pirarubicin disrupts neoplasm"" supported by the sentence: ""As THP-ADM proved to be more cytotoxic than ADM to human tumors in vitro, this drug should be kept in mind when anti-cancer chemotherapy is designed.""?",False, +14778803,Pirarubicin prevents neoplasm,2283,"Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.","Is the triple ""Pirarubicin prevents neoplasm"" supported by the sentence: ""Thereby as an intercalator of DNA, pirarubicin has shown efficacy in reducing tumor activity of hepatocellular carcinoma.""?",False, +20218174,Mitoxantrone subclass of Mitoxantrone dicarboxylic acid,2284,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone subclass of Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, +25737166,Mitoxantrone related to lymphoma,2285,"Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.","Is the triple ""Mitoxantrone related to lymphoma"" supported by the sentence: ""Based on the results of our phase II studies of mitoxantrone, etoposide, and cisplatin in malignant lymphoma, we have conducted a phase III study of a 4-drug combination of these 3 drugs plus prednisolone in relapsed or refractory lymphoma: Out of 14 patients, 3 responded completely and 4 did partially, so far.""?",False, +19961419,Mitoxantrone related to breast neoplasm,2286,Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.,"Is the triple ""Mitoxantrone related to breast neoplasm"" supported by the sentence: ""Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.""?",False, +14217137,Mitoxantrone related to mantle cell lymphoma,2287,Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.,"Is the triple ""Mitoxantrone related to mantle cell lymphoma"" supported by the sentence: ""Combinations of bendamustine with mitoxantrone and rituximab and with rituximab alone have been shown to be highly active in relapsed/refractory indolent lymphomas and mantle cell lymphomas achieving long lasting complete remissions.""?",False, +13051364,Mitoxantrone related to multiple sclerosis,2288,"Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.","Is the triple ""Mitoxantrone related to multiple sclerosis"" supported by the sentence: ""Pharmacokinetics and pharmacodynamics of the interferon-betas, glatiramer acetate, and mitoxantrone in multiple sclerosis.""?",False, +8903075,Mitoxantrone related to acute myeloid leukemia,2289,"Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.","Is the triple ""Mitoxantrone related to acute myeloid leukemia"" supported by the sentence: ""Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia.""?",False, +8584278,Mitoxantrone causes acute myeloid leukemia,2290,"CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.","Is the triple ""Mitoxantrone causes acute myeloid leukemia"" supported by the sentence: ""CONCLUSIONS: The combination of mitoxantrone with cyclophosphamide, fluorouracil, and radiation therapy can induce t-AML, as with other topoisomerase II-targeted drugs.""?",False, +26143277,Mitoxantrone affects lymphoma,2291,"Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.","Is the triple ""Mitoxantrone affects lymphoma"" supported by the sentence: ""Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities.""?",False, +20218175,Mitoxantrone affects Mitoxantrone dicarboxylic acid,2292,"During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.","Is the triple ""Mitoxantrone affects Mitoxantrone dicarboxylic acid"" supported by the sentence: ""During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified.""?",False, +11986455,Mitoxantrone affects multiple sclerosis,2293,Therapeutic role of mitoxantrone in multiple sclerosis.,"Is the triple ""Mitoxantrone affects multiple sclerosis"" supported by the sentence: ""Therapeutic role of mitoxantrone in multiple sclerosis.""?",False, +9134230,Mitoxantrone prevents neoplasm,2294,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Mitoxantrone prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, +11307631,Mitoxantrone exacerbates multiple sclerosis,2295,Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.,"Is the triple ""Mitoxantrone exacerbates multiple sclerosis"" supported by the sentence: ""Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate.""?",False, +26844498,Doxorubicin related to renal cell carcinoma,2296,Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.,"Is the triple ""Doxorubicin related to renal cell carcinoma"" supported by the sentence: ""Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma.""?",False, +26506763,Doxorubicin related to Kaposi's sarcoma,2297,"The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.","Is the triple ""Doxorubicin related to Kaposi's sarcoma"" supported by the sentence: ""The efficacy and toxicity of doxorubicin, bleomycin and vindesine in epidemic Kaposi's sarcoma, and the role of rh GM-CSF in chemotherapy-induced neutropenia were evaluated in this Phase II study.""?",False, +26097255,Doxorubicin related to hepatocellular carcinoma,2298,The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.,"Is the triple ""Doxorubicin related to hepatocellular carcinoma"" supported by the sentence: ""The combination of doxorubicin and streptozotocin has only modest activity in hepatocellular carcinoma and appears no more active than doxorubicin alone.""?",False, +25468576,Doxorubicin related to non-Hodgkin lymphoma,2299,"OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.","Is the triple ""Doxorubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""OBJECTIVE: Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone, once every 3 weeks (R-CHOP21) is commonly used in non-Hodgkin's lymphoma (NHL), but accompanied by Pneumocystis carinii pneumonia (PCP) as a fatal treatment complication.""?",False, +21586070,Doxorubicin related to diffuse large B-cell lymphoma,2300,"Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.","Is the triple ""Doxorubicin related to diffuse large B-cell lymphoma"" supported by the sentence: ""Expression of hypoxia-inducible factor-1a predicts benefit from rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in diffuse large B-cell lymphoma.""?",False, +17293414,Doxorubicin related to neoplasm,2301,"Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.","Is the triple ""Doxorubicin related to neoplasm"" supported by the sentence: ""Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors.""?",False, +14824461,Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma,2302,"A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.","Is the triple ""Doxorubicin related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""A phase II study of alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas.""?",False, +12975330,"Doxorubicin related to Lymphoma, AIDS-Related",2303,"BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.","Is the triple ""Doxorubicin related to Lymphoma, AIDS-Related"" supported by the sentence: ""BACKGROUND AND OBJECTIVES: Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is scarce.""?",False, +12635005,Doxorubicin related to neuroendocrine neoplasm,2304,"Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.","Is the triple ""Doxorubicin related to neuroendocrine neoplasm"" supported by the sentence: ""Streptozocin, 5-fluorouracil, and doxorubicin are the most widely used chemotherapeutic agents in metastatic neuroendocrine tumors; their efficacy is limited, and significant side effects limit their use.""?",False, +11664648,Doxorubicin related to non-small cell lung carcinoma,2305,"Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.","Is the triple ""Doxorubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Our recent findings indicate a role of RLIP76, a non-ATP binding cassette transport protein, in catalyzing the ATP-dependent efflux of structurally and functionally unrelated chemotherapeutic agents such as doxorubicin and vinblastine in NSCLC.""?",False, +8248824,Doxorubicin related to lymphoma,2306,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Doxorubicin related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, +7897058,Doxorubicin related to leukemia,2307,Combined effect of lipoic acid and doxorubicin in murine leukemia.,"Is the triple ""Doxorubicin related to leukemia"" supported by the sentence: ""Combined effect of lipoic acid and doxorubicin in murine leukemia.""?",False, +7111309,Doxorubicin related to Hodgkins lymphoma,2308,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Doxorubicin related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, +26198671,Doxorubicin causes acute myeloid leukemia,2309,"Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.","Is the triple ""Doxorubicin causes acute myeloid leukemia"" supported by the sentence: ""Remission of AML was induced by doxorubicin, vincristine, and cytosine arabinoside.""?",False, +20905498,Doxorubicin causes prostate cancer,2310,"In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.","Is the triple ""Doxorubicin causes prostate cancer"" supported by the sentence: ""In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells.""?",False, +19998968,Doxorubicin causes Hodgkins lymphoma,2311,"Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.","Is the triple ""Doxorubicin causes Hodgkins lymphoma"" supported by the sentence: ""Combined with doxorubicin, IMMU-140 produced significantly greater antitumor effects in HL than with monotherapy and without any added toxicity.""?",False, +17176693,Doxorubicin causes B-cell neoplasm,2312,"Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.","Is the triple ""Doxorubicin causes B-cell neoplasm"" supported by the sentence: ""Complement-fixing monoclonal antibody DLC-48 was linked covalently to doxorubicin using two methodologies, and the resulting conjugates were evaluated for their usefulness in purging B-cell lymphomas from human bone marrow autografts using a clonogenic assay for the large cell lymphoma cell line SU-DHL-4.""?",False, +16306119,Doxorubicin causes hepatocellular carcinoma,2313,"In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.","Is the triple ""Doxorubicin causes hepatocellular carcinoma"" supported by the sentence: ""In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.""?",False, +14936910,Doxorubicin causes plasma cell myeloma,2314,"Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.","Is the triple ""Doxorubicin causes plasma cell myeloma"" supported by the sentence: ""Combining MLN8237 with dexamethasone, doxorubicin, or bortezomib induces synergistic/additive anti-MM activity in vitro.""?",False, +13613509,Doxorubicin causes sarcoma,2315,Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.,"Is the triple ""Doxorubicin causes sarcoma"" supported by the sentence: ""Doxorubicin did not increase the rate of development of radiation induced sarcomas in mice treated with combined modality.""?",False, +12176485,"Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive",2316,"Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.","Is the triple ""Doxorubicin causes blast phase chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Moreover, Lbc expression confers increased resistance to genotoxic stress induced by doxorubicin, which is associated with upregulation of Bcl-2 and BAD phosphorylation, and this is reversed by a Rho inhibitor.""?",False, +12086573,Doxorubicin causes leukemia,2317,"We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.","Is the triple ""Doxorubicin causes leukemia"" supported by the sentence: ""We previously observed by gene profiling that sorcin is significantly up-regulated in a doxorubicin-induced MDR leukemia cell line, K562/A02, over its parent cells.""?",False, +11480674,Doxorubicin causes Neoplasm Metastasis,2318,"The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.","Is the triple ""Doxorubicin causes Neoplasm Metastasis"" supported by the sentence: ""The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice.""?",False, +11088747,Doxorubicin causes neoplasm,2319,"Furthermore, doxorubicin is known to induce tumor resistance genes.","Is the triple ""Doxorubicin causes neoplasm"" supported by the sentence: ""Furthermore, doxorubicin is known to induce tumor resistance genes.""?",False, +7374660,Doxorubicin causes neutropenia,2320,"Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.","Is the triple ""Doxorubicin causes neutropenia"" supported by the sentence: ""Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting.""?",False, +25410483,Doxorubicin affects glioma,2321,"By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.","Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""By virtue of the surface pathogen-associated molecular patterns derived from native bacteria, OMVs/DOX could be selectively recognized by neutrophils, thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.""?",False, +25202161,Doxorubicin affects glioblastoma,2322,The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.,"Is the triple ""Doxorubicin affects glioblastoma"" supported by the sentence: ""The Chemo-Sensitizing Effect of Doxorubicin of Apple Extract-Enriched Triterpenic Complex on Human Colon Adenocarcinoma and Human Glioblastoma Cell Lines.""?",False, +24066270,Doxorubicin affects triple-negative breast carcinoma,2323,Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.,"Is the triple ""Doxorubicin affects triple-negative breast carcinoma"" supported by the sentence: ""Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer.""?",False, +23980169,Doxorubicin affects hematopoietic and lymphoid system neoplasm,2324,"Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.","Is the triple ""Doxorubicin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Doxorubicin (Dox), an important anthracycline, is a potent anticancer agent that is used for treating solid tumors and hematologic malignancies.""?",False, +20976248,Doxorubicin affects neuroblastoma,2325,"For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.","Is the triple ""Doxorubicin affects neuroblastoma"" supported by the sentence: ""For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma.""?",False, +20526631,Doxorubicin affects gastric neoplasm,2326,"Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.","Is the triple ""Doxorubicin affects gastric neoplasm"" supported by the sentence: ""Ectopic downregulation of Notch1 expression enhanced the sensitivity of GC tumors to doxorubicin, which suppressed the development of GC.""?",False, +20464122,Doxorubicin affects T-cell non-Hodgkin lymphoma,2327,"Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.","Is the triple ""Doxorubicin affects T-cell non-Hodgkin lymphoma"" supported by the sentence: ""Moreover, PIM1 silencing via siRNA suppressed c-myc expression, promoted the cell death of TCLs, and increased doxorubicin sensitivity.""?",False, +19907850,Doxorubicin affects renal cell carcinoma,2328,"Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.","Is the triple ""Doxorubicin affects renal cell carcinoma"" supported by the sentence: ""Synergistic effects of 15-deoxy Delta12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma.""?",False, +18966824,Doxorubicin affects leiomyosarcoma,2329,"Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.","Is the triple ""Doxorubicin affects leiomyosarcoma"" supported by the sentence: ""Antiapoptotic proteins are highly expressed in leiomyosarcoma of soft tissue, and inhibition of these proteins using a BH3 mimetic increases leiomyosarcoma sensitivity to doxorubicin.""?",False, +18841320,Doxorubicin affects B-cell chronic lymphocytic leukemia,2330,This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.,"Is the triple ""Doxorubicin affects B-cell chronic lymphocytic leukemia"" supported by the sentence: ""This third interim analysis confirms the results of the first interim analysis that led to an early stopping of this clinical trial and clearly indicates the beneficial effect of low doses of doxorubicin in advanced chronic lymphocytic leukaemia.""?",False, +17410518,Doxorubicin affects rhabdomyosarcoma,2331,The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.,"Is the triple ""Doxorubicin affects rhabdomyosarcoma"" supported by the sentence: ""The current European EpSSG 2005 study for high-risk RMS (by the European definition) may come closest to giving an answer to the role of doxorubicin in RMS.""?",False, +17166104,Doxorubicin affects mesothelioma,2332,"METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.","Is the triple ""Doxorubicin affects mesothelioma"" supported by the sentence: ""METHODS: PC tissue samples (n = 174) from mesothelioma, pseudomyxoma peritonei (PMP), ovarian cancer, CRC or appendix cancer were analyzed ex vivo for sensitivity to oxaliplatin, cisplatin, mitomycin C, melphalan, irinotecan, docetaxel, doxorubicin and 5-FU.""?",False, +17156749,Doxorubicin affects non-Hodgkin lymphoma,2333,From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).,"Is the triple ""Doxorubicin affects non-Hodgkin lymphoma"" supported by the sentence: ""From 1981 to 1984 a randomized clinical trial was conducted to evaluate the role of doxorubicin in low grade malignancy non-Hodgkin's lymphoma (NHL).""?",False, +17092174,Doxorubicin affects glioma,2334,Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.,"Is the triple ""Doxorubicin affects glioma"" supported by the sentence: ""Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.""?",False, +16319458,Doxorubicin affects sarcoma,2335,Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.,"Is the triple ""Doxorubicin affects sarcoma"" supported by the sentence: ""Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.""?",False, +15641121,Doxorubicin affects liver and intrahepatic bile duct neoplasm,2336,"The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.","Is the triple ""Doxorubicin affects liver and intrahepatic bile duct neoplasm"" supported by the sentence: ""The difference in response to DOX between s.c. tumors (sensitive) and liver tumors (resistant) was not due to selection of cell populations with different sensitivity to DOX, or differences in DOX distribution.""?",False, +15592048,Doxorubicin affects diffuse large B-cell lymphoma,2337,"Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.","Is the triple ""Doxorubicin affects diffuse large B-cell lymphoma"" supported by the sentence: ""Whole genome, high resolution array comparative genomic hybridization (aCGH) was performed on four cases of chemoresistant DLBCL and four cases of chemo-responsive DLBCL to identify genetic differences that may correlate with response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy.""?",False, +15335028,Doxorubicin affects pancreatic ductal adenocarcinoma,2338,"We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.","Is the triple ""Doxorubicin affects pancreatic ductal adenocarcinoma"" supported by the sentence: ""We evaluated the combination effects of EMAP, doxorubicin, and docetaxel in experimental PDAC.""?",False, +15288278,Doxorubicin affects mantle cell lymphoma,2339,"Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.","Is the triple ""Doxorubicin affects mantle cell lymphoma"" supported by the sentence: ""Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.""?",False, +15233880,Doxorubicin affects prostate cancer,2340,"In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.","Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer.""?",False, +14862593,Doxorubicin affects liposarcoma,2341,"We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.","Is the triple ""Doxorubicin affects liposarcoma"" supported by the sentence: ""We also show the utility of this model, together with two additional human liposarcoma cell lines, to investigate the relationship between topoisomerase 2A expression and the sensitivity of ALT-positive liposarcomas to doxorubicin.""?",False, +13717435,Doxorubicin affects prostate cancer,2342,CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.,"Is the triple ""Doxorubicin affects prostate cancer"" supported by the sentence: ""CONCLUSIONS: Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.""?",False, +13641465,Doxorubicin affects Ewing sarcoma,2343,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects Ewing sarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, +13641464,Doxorubicin affects bone osteosarcoma,2344,Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.,"Is the triple ""Doxorubicin affects bone osteosarcoma"" supported by the sentence: ""Our analysis suggests that doxorubicin dose intensity is an important determinant of favorable outcome for both Ewing's sarcoma and osteogenic sarcoma and that the dose intensities of other agents do not contribute as significantly to outcome as does doxorubicin dose intensity.""?",False, +13477582,Doxorubicin affects hepatocellular carcinoma,2345,Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.,"Is the triple ""Doxorubicin affects hepatocellular carcinoma"" supported by the sentence: ""Combined DOX and rAAV2-p53 administration may facilitate more efficient treatment for the HCC caused by p53 mutations.""?",False, +12593977,Doxorubicin affects Kaposi's sarcoma,2346,Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.,"Is the triple ""Doxorubicin affects Kaposi's sarcoma"" supported by the sentence: ""Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic review.""?",False, +12038917,Doxorubicin affects acute lymphoblastic leukemia,2347,Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.,"Is the triple ""Doxorubicin affects acute lymphoblastic leukemia"" supported by the sentence: ""Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l-asparaginase.""?",False, +11963770,Doxorubicin affects angiosarcoma,2348,DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.,"Is the triple ""Doxorubicin affects angiosarcoma"" supported by the sentence: ""DISCUSSION: Angiosarcoma is an aggressive malignancy characterized by biologic heterogeneity at different anatomic sites and relative sensitivity to paclitaxel and doxorubicin.""?",False, +11068243,Doxorubicin affects neutropenia,2349,"Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.","Is the triple ""Doxorubicin affects neutropenia"" supported by the sentence: ""Alopecia (overall, 66% versus 20%; pronounced, 54% versus 7%), nausea (53% versus 37%), vomiting (31% versus 19%) and neutropenia (10% versus 4%) were more often associated with doxorubicin than PLD.""?",False, +9029101,Doxorubicin affects neoplasm,2350,"Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy.""?",False, +7957058,Doxorubicin affects neoplasm,2351,"In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.","Is the triple ""Doxorubicin affects neoplasm"" supported by the sentence: ""In conjunction with these toxicity buffering effects, the effect of PGP blockade on the cellular uptake of DOX in the tumor may be able to be selectively increased using liposomal carriers.""?",False, +7468708,Doxorubicin affects carcinoma,2352,Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.,"Is the triple ""Doxorubicin affects carcinoma"" supported by the sentence: ""Carcinomas that were positive for Fas and FasL demonstrated a greater sensitivity to doxorubicin in vitro.""?",False, +7221748,Doxorubicin affects small cell lung carcinoma,2353,"Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.","Is the triple ""Doxorubicin affects small cell lung carcinoma"" supported by the sentence: ""Using both SCLC and non-SCLC cell lines, we confirmed the previously observed correlation of MRP mRNA levels with resistance to DOX (B.""?",False, +22415368,Doxorubicin disrupts glioma,2354,"In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.","Is the triple ""Doxorubicin disrupts glioma"" supported by the sentence: ""In addition, Fn-Rev-Ang-loaded doxorubicin had a strong inhibitory effect on mouse brain gliomas and their metastasis, which significantly prolonged the animal survival time.""?",False, +21775806,Doxorubicin disrupts non-small cell lung carcinoma,2355,Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.,"Is the triple ""Doxorubicin disrupts non-small cell lung carcinoma"" supported by the sentence: ""Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer.""?",False, +19908932,Doxorubicin disrupts hematopoietic and lymphoid system neoplasm,2356,Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.,"Is the triple ""Doxorubicin disrupts hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.""?",False, +19216444,Doxorubicin disrupts lymphoma,2357,Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.,"Is the triple ""Doxorubicin disrupts lymphoma"" supported by the sentence: ""Stereocomplex micelle efficiently transports Doxorubicin for enhanced lymphoma suppression in vivo.""?",False, +18593046,Doxorubicin disrupts bone osteosarcoma,2358,"A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.","Is the triple ""Doxorubicin disrupts bone osteosarcoma"" supported by the sentence: ""A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.""?",False, +17338969,Doxorubicin disrupts melanoma,2359,In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).,"Is the triple ""Doxorubicin disrupts melanoma"" supported by the sentence: ""In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light).""?",False, +15233882,Doxorubicin disrupts prostate cancer,2360,"In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.","Is the triple ""Doxorubicin disrupts prostate cancer"" supported by the sentence: ""In conclusion, these results provide provocative evidence that sildenafil is both a powerful sensitizer of DOX-induced killing of prostate cancer while providing concurrent cardioprotective benefit.""?",False, +15026936,Doxorubicin disrupts B-cell neoplasm,2361,"RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.","Is the triple ""Doxorubicin disrupts B-cell neoplasm"" supported by the sentence: ""RESULTS: In vitro, CMC-544 was more potent in causing growth inhibition of various BCL than cyclophosphamide, doxorubicin, vincristine or dexamethasone.""?",False, +14123664,Doxorubicin disrupts hepatocellular carcinoma,2362,CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.,"Is the triple ""Doxorubicin disrupts hepatocellular carcinoma"" supported by the sentence: ""CONCLUSION: Endostatin gene therapy synergizes with doxorubicin to suppress HCC.""?",False, +11529496,Doxorubicin disrupts neuroblastoma,2363,"We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.","Is the triple ""Doxorubicin disrupts neuroblastoma"" supported by the sentence: ""We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear.""?",False, +8800155,Doxorubicin disrupts neoplasm,2364,"Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).","Is the triple ""Doxorubicin disrupts neoplasm"" supported by the sentence: ""Docetaxel-doxorubicin combinations were most effective following dosing in the beginning of the rest span or short after the onset of the activity span, with regard to the rates of both complete tumor inhibitions (45% at 3 HALO versus 15% at 19 HALO) and day 70 survival rates (85% and 80% at 3 and 7 HALO respectively, versus 20% at 19 HALO).""?",False, +8316270,Doxorubicin disrupts Neoplasm Metastasis,2365,"However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.","Is the triple ""Doxorubicin disrupts Neoplasm Metastasis"" supported by the sentence: ""However, combination of BP with anticancer agents such as uracil and tegafur or doxorubicin suppressed the metastases not only in bone but also visceral organs and prolonged the survival in 4T1 mammary tumor-bearing animals.""?",False, +24403937,Doxorubicin prevents triple-negative breast carcinoma,2366,"Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.","Is the triple ""Doxorubicin prevents triple-negative breast carcinoma"" supported by the sentence: ""Overall, the tumor penetrating, hypoxia-responsive exosomes encapsulating doxorubicin would be effective in reducing triple-negative breast cancer cells' survival.""?",False, +23195923,Doxorubicin prevents lung neoplasm,2367,In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.,"Is the triple ""Doxorubicin prevents lung neoplasm"" supported by the sentence: ""In vivo studies in an NSCLC model of mice indicated that SA-5-Dox-LP could reduce the lung tumors significantly compared to vehicle control and Dox.""?",False, +22365593,Doxorubicin prevents leukemia,2368,"Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.","Is the triple ""Doxorubicin prevents leukemia"" supported by the sentence: ""Notably, cardioprotection does not compromise the efficacy of doxorubicin in reducing leukemia or breast cancer burden in vivo, primarily due to increased priming of mitochondrial death mechanisms and higher BAX levels in cancer cells.""?",False, +15227703,Doxorubicin prevents sarcoma,2369,"In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.","Is the triple ""Doxorubicin prevents sarcoma"" supported by the sentence: ""In this study, we showed that a synthesized analog of cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of an aggressive sarcoma derived from transformed mesenchymal stem cells in syngeneic rats.""?",False, +10708896,Doxorubicin prevents urinary bladder neoplasm,2370,"CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.","Is the triple ""Doxorubicin prevents urinary bladder neoplasm"" supported by the sentence: ""CONCLUSIONS: Several randomized clinical trials suggest that BCG is superior to thiotepa, doxorubicin, and mitomycin in preventing bladder tumor recurrence and tumor progression.""?",False, +8872024,Doxorubicin prevents Neoplasm Metastasis,2371,"Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.","Is the triple ""Doxorubicin prevents Neoplasm Metastasis"" supported by the sentence: ""Finally, using the MDA-MB-435 orthotopic model of metastatic breast cancer, we have examined the effect of systemic administration of Adp53, alone or in combination with doxorubicin, to reduce the incidence of metastases.""?",False, +8737011,Doxorubicin prevents neutropenia,2372,"CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.","Is the triple ""Doxorubicin prevents neutropenia"" supported by the sentence: ""CONCLUSION: Myocet improves the therapeutic index of doxorubicin by significantly reducing cardiotoxicity and grade 4 neutropenia and provides comparable antitumor efficacy, when used in combination with cyclophosphamide as first-line therapy for MBC.""?",False, +7721507,Doxorubicin prevents neoplasm,2373,"(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.","Is the triple ""Doxorubicin prevents neoplasm"" supported by the sentence: ""(4) The use of dexrazoxane can be considered in adult patients who have received more than 300 mg/m(2) of doxorubicin-based therapy for tumors other than breast cancer, although caution should be used in settings in which doxorubicin-based therapy has been shown to improve survival because of concerns of tumor protection by dexrazoxane.""?",False, +18908502,Doxorubicin exacerbates neoplasm,2374,"Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.","Is the triple ""Doxorubicin exacerbates neoplasm"" supported by the sentence: ""Synergistic combination of doxorubicin (DOX) and paclitaxel (PTX), compared with using them separately, could more efficiently suppress tumor aggravation.""?",False, +25000938,Doxorubicin predisposes bone osteosarcoma,2375,"CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.","Is the triple ""Doxorubicin predisposes bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Hsa_circ_0010220 encouraged OS resistance to DOX by miR-574-3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.""?",False, +20426915,Doxorubicin predisposes neoplasm,2376,Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.,"Is the triple ""Doxorubicin predisposes neoplasm"" supported by the sentence: ""Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity.""?",False, +19669792,Doxorubicin predisposes sarcoma,2377,"Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.","Is the triple ""Doxorubicin predisposes sarcoma"" supported by the sentence: ""Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas.""?",False, +18137816,Doxorubicin predisposes lymphoma,2378,"Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.","Is the triple ""Doxorubicin predisposes lymphoma"" supported by the sentence: ""Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining.""?",False, +12722667,Doxorubicin predisposes acute myeloid leukemia,2379,"Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.","Is the triple ""Doxorubicin predisposes acute myeloid leukemia"" supported by the sentence: ""Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly.""?",False, +8803332,Doxorubicin predisposes kidney Wilms tumor,2380,CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.,"Is the triple ""Doxorubicin predisposes kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: We conclude that congestive heart failure is a risk of treatment with doxorubicin for Wilms' tumor.""?",False, +7173827,Doxorubicin predisposes leukemia,2381,"CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.","Is the triple ""Doxorubicin predisposes leukemia"" supported by the sentence: ""CONCLUSION: Within the context of the epipodophyllotoxin cumulative dose range and schedules of administration encompassed by the monitoring plan regimens, and within the context of multiagent chemotherapy regimens that include alkylating agents, doxorubicin, and other agents, factors other than epipodophyllotoxin cumulative dose seem to be of primary importance in determining the risk of secondary leukemia.""?",False, +26966260,Iproniazid related to Monoamine Oxidase,2382,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, +26966260,Iproniazid related to Monoamine Oxidase,2383,They all inhibit monoamine oxidase and are more active than iproniazid.,"Is the triple ""Iproniazid related to Monoamine Oxidase"" supported by the sentence: ""They all inhibit monoamine oxidase and are more active than iproniazid.""?",False, +10565399,Iproniazid physically interacts with Monoamine Oxidase,2384,The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.,"Is the triple ""Iproniazid physically interacts with Monoamine Oxidase"" supported by the sentence: ""The relationship between iproniazid metabolism and the duration of its effect on monoamine oxidase.""?",False, +12902070,Iproniazid affects depressive disorder,2385,"Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.","Is the triple ""Iproniazid affects depressive disorder"" supported by the sentence: ""Atypical depression, one of the 4 historically important ways of subdividing depression, was first used by West and Dally to describe a patient subgroup that was nonresponsive to imipramine but responsive to iproniazid.""?",False, +9833655,Iproniazid affects Monoamine Oxidase,2386,"The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.","Is the triple ""Iproniazid affects Monoamine Oxidase"" supported by the sentence: ""The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.""?",False, +10498318,Epirubicin related to non-small cell lung carcinoma,2387,Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.,"Is the triple ""Epirubicin related to non-small cell lung carcinoma"" supported by the sentence: ""Phase II study of high-dose epirubicin and etoposide in advanced non-small cell lung cancer.""?",False, +10228088,Epirubicin related to ovarian cancer,2388,Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.,"Is the triple ""Epirubicin related to ovarian cancer"" supported by the sentence: ""Escalating doses of paclitaxel and epirubicin in combination with cisplatin in advanced ovarian epithelial carcinoma: a phase I-II study.""?",False, +10182077,Epirubicin related to non-Hodgkin lymphoma,2389,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, +10182076,Epirubicin related to Hodgkins lymphoma,2390,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Epirubicin related to Hodgkins lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, +8413603,Epirubicin related to small cell lung carcinoma,2391,"Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.","Is the triple ""Epirubicin related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with tamoxifen, ifosfamide, epirubicin and cisplatin in extensive-disease small-cell lung cancer.""?",False, +7746533,Epirubicin related to castration-resistant prostate carcinoma,2392,"The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.","Is the triple ""Epirubicin related to castration-resistant prostate carcinoma"" supported by the sentence: ""The synergism between anthracyclines and cisplatin, with the lack of overlapping toxicities, led to the conduct of this phase II trial of the combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.""?",False, +26737878,Epirubicin physically interacts with 7-Deoxydoxorubicinone,2393,"In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.","Is the triple ""Epirubicin physically interacts with 7-Deoxydoxorubicinone"" supported by the sentence: ""In this study, the in vitro interaction of epirubicin (EPR), a cytostatic antibiotic, with plasma proteins (PP), namely alpha-HSA, gamma-HSG, alpha+beta-HSG and with isolated human red blood cells (RBCs) was investigated and further correlated with the in vivo pharmacokinetics and binding of EPR and two of its metabolites, 13-dihydroepirubicin and 7-deoxydoxorubicinone to RBCs.""?",False, +18781215,Epirubicin causes neoplasm,2394,"In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.","Is the triple ""Epirubicin causes neoplasm"" supported by the sentence: ""In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice.""?",False, +26736958,Epirubicin affects hepatocellular carcinoma,2395,"Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.","Is the triple ""Epirubicin affects hepatocellular carcinoma"" supported by the sentence: ""Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma.""?",False, +12104701,Epirubicin affects neoplasm,2396,RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.,"Is the triple ""Epirubicin affects neoplasm"" supported by the sentence: ""RESULTS: HER2-positivity was found in 33% of the 805 investigated tumors and was not a predictive marker for epirubicin sensitivity.""?",False, +14784473,Epirubicin prevents neoplasm,2397,"The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.","Is the triple ""Epirubicin prevents neoplasm"" supported by the sentence: ""The extensive evidence suggests that an immediate post-operative instillation of a chemotherapeutic agent, such as Mitomycin C or Epirubicin, is effective in reducing tumour recurrence.""?",False, +10544897,Nialamide physically interacts with Monoamine Oxidase,2398,"The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.","Is the triple ""Nialamide physically interacts with Monoamine Oxidase"" supported by the sentence: ""The region-specific effects of 5-HT and nialamide in glial co-cultures suggest that raphe and mesencephalic glia may express different capacities for 5-HT uptake, receptors, and/or monoamine oxidase (MAO) activities.""?",False, +9388429,Nialamide affects Monoamine Oxidase,2399,"Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.","Is the triple ""Nialamide affects Monoamine Oxidase"" supported by the sentence: ""Furthermore, monoamine oxidase inhibition by nialamide did not appear to increase the neurotoxicity of 6-OHDA.""?",False, +10646811,Isocarboxazid affects Monoamine Oxidase,2400,Monoamine oxidase inhibition by isocarboxazid.,"Is the triple ""Isocarboxazid affects Monoamine Oxidase"" supported by the sentence: ""Monoamine oxidase inhibition by isocarboxazid.""?",False, +14451724,Valacyclovir causes psychotic disorder,2401,"Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.","Is the triple ""Valacyclovir causes psychotic disorder"" supported by the sentence: ""Clinicians should be aware that valacyclovir may induce psychosis with manic presentation in young, healthy patients without a psychiatric history.""?",False, +27205274,Valacyclovir affects postherpetic neuralgia,2402,"The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.","Is the triple ""Valacyclovir affects postherpetic neuralgia"" supported by the sentence: ""The nucleoside analogues, aciclovir, famciclovir and valaciclovir, appear to shorten the duration of PHN to a similar degree, but none affects the incidence of PHN.""?",False, +25557382,Valacyclovir affects Pregnancy,2403,"METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).","Is the triple ""Valacyclovir affects Pregnancy"" supported by the sentence: ""METHODS: We compared four strategies of screening for CMV during pregnancy in France: no screening (S1), current screening in ""real life"" (25 to 50% pregnant women) (S2), universal screening (S3) and universal screening associated with valaciclovir in case of T1 PI (S4).""?",False, +19384061,Valacyclovir disrupts herpes simplex infectious disease,2404,Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.,"Is the triple ""Valacyclovir disrupts herpes simplex infectious disease"" supported by the sentence: ""Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection.""?",False, +14963245,Valacyclovir disrupts herpes zoster,2405,VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.,"Is the triple ""Valacyclovir disrupts herpes zoster"" supported by the sentence: ""VACV at a dose of 1000 mg twice daily through 24 months after transplant is well tolerated and effective in suppressing shingles after SCT.""?",False, +10778326,Valacyclovir disrupts viral infectious disease,2406,"To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.","Is the triple ""Valacyclovir disrupts viral infectious disease"" supported by the sentence: ""To determine the efficacy and safety of valacyclovir (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in human immunodeficiency virus (HIV)-infected subjects, a randomized, double-blind, placebo-controlled, multicenter international trial was conducted.""?",False, +10108851,Valacyclovir disrupts herpes labialis,2407,The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.,"Is the triple ""Valacyclovir disrupts herpes labialis"" supported by the sentence: ""The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported.""?",False, +8112054,Valacyclovir disrupts genital herpes,2408,"METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.","Is the triple ""Valacyclovir disrupts genital herpes"" supported by the sentence: ""METHODS: Health related quality of life was measured using the disease specific recurrent genital herpes quality of life questionnaire (RGHQoL) as part of a randomized, double blind, 52 week, placebo controlled, dose ranging study of once and twice daily valaciclovir or aciclovir for the suppression of recurrent genital herpes in patients with six or more recurrences per year.""?",False, +19368060,Valacyclovir prevents postherpetic neuralgia,2409,FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.,"Is the triple ""Valacyclovir prevents postherpetic neuralgia"" supported by the sentence: ""FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial.""?",False, +12346968,Valacyclovir prevents genital herpes,2410,Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.,"Is the triple ""Valacyclovir prevents genital herpes"" supported by the sentence: ""Valacyclovir therapy to reduce recurrent genital herpes in pregnant women.""?",False, +10108849,Valacyclovir prevents herpes labialis,2411,"Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.","Is the triple ""Valacyclovir prevents herpes labialis"" supported by the sentence: ""Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies.""?",False, +9970234,Valacyclovir prevents herpes simplex infectious disease,2412,Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.,"Is the triple ""Valacyclovir prevents herpes simplex infectious disease"" supported by the sentence: ""Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.""?",False, +8018684,Valacyclovir prevents cytomegalovirus infection,2413,The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.,"Is the triple ""Valacyclovir prevents cytomegalovirus infection"" supported by the sentence: ""The renal safety of high doses of valacyclovir for prevention of cytomegalovirus infection after renal transplantation.""?",False, +8899981,Cidofovir affects cytomegalovirus retinitis,2414,The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.,"Is the triple ""Cidofovir affects cytomegalovirus retinitis"" supported by the sentence: ""The decision was based on two studies showing that immediate cidofovir therapy can delay CMV retinitis progression.""?",False, +7346321,Cidofovir affects viral infectious disease,2415,The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.,"Is the triple ""Cidofovir affects viral infectious disease"" supported by the sentence: ""The purpose of the present study was to examine the hypothesis that the topical effectiveness of cidofovir (HPMPC) would not be a single valued function of C and that it would be dependent upon when the therapy was initiated relative to the time of viral infection.""?",False, +11567412,Cidofovir disrupts cytomegalovirus infection,2416,These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.,"Is the triple ""Cidofovir disrupts cytomegalovirus infection"" supported by the sentence: ""These results indicate that HPMPC is not toxic to the rabbit retina at 500-1000-fold the dose that is effective in suppressing CMV infections.""?",False, +27502123,Cidofovir prevents herpes simplex infectious disease,2417,Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.,"Is the triple ""Cidofovir prevents herpes simplex infectious disease"" supported by the sentence: ""Animal studies have shown cidofovir to be effective in the treatment and prevention of HSV infections.""?",False, +16212718,Cidofovir prevents cytomegalovirus infection,2418,"* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.","Is the triple ""Cidofovir prevents cytomegalovirus infection"" supported by the sentence: ""* Ganciclovir, valganciclovir, foscarnet, cidofovir, and CMV hyperimmune globulin are effective in treating or preventing CMV infections in the immunocompromised host, but require close monitoring for associated toxicities.""?",False, +11248462,Cidofovir prevents viral infectious disease,2419,"Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.","Is the triple ""Cidofovir prevents viral infectious disease"" supported by the sentence: ""Although some protection was achieved with systemic treatment, 5% topical CDV was most effective at reducing virus titers in skin, lung, kidney, and spleen.""?",False, +26922185,Penciclovir affects viral infectious disease,2420,"Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.","Is the triple ""Penciclovir affects viral infectious disease"" supported by the sentence: ""Sensitivity of thymidine kinase (TK)-deficient virus to penciclovir and of some DNA polymerase (DPase) mutants to sorivudine suggested that these drugs might be used for the treatment of vaccine recipients, even if Oka varicella vaccine became acyclovir-resistant by mutations in the TK or DPase genes, respectively.""?",False, +22087736,Valganciclovir affects cytomegalovirus infection,2421,The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.,"Is the triple ""Valganciclovir affects cytomegalovirus infection"" supported by the sentence: ""The goal of this study is to evaluate if adding CMV IVIG to VGC impacts the rates of CMV infection.""?",False, +18756429,Valganciclovir affects sensorineural hearing loss disorder,2422,IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.,"Is the triple ""Valganciclovir affects sensorineural hearing loss disorder"" supported by the sentence: ""IMPLICATIONS FOR RESEARCH: The need for research exists in the area of valganciclovir's impact on sensorineural hearing loss as well as potential vaccines to protect against CMV transmission.""?",False, +20121657,Valganciclovir disrupts cytomegalovirus infection,2423,"CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.","Is the triple ""Valganciclovir disrupts cytomegalovirus infection"" supported by the sentence: ""CONCLUSIONS: An EHR-based, pharmacist-driven valganciclovir dose optimization program was associated with reduction in CMV infections.""?",False, +12085189,Valganciclovir prevents sensorineural hearing loss disorder,2424,"We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.","Is the triple ""Valganciclovir prevents sensorineural hearing loss disorder"" supported by the sentence: ""We present a neonate with symptomatic congenital CMV infection, who was treated with intravenous (iv) ganciclovir (GCV) during 18 days and subsequently with oral valganciclovir (VGCV) for 5.5 months, in an attempt to prevent development of SNHL.""?",False, +11282399,Valganciclovir prevents cytomegalovirus infection,2425,"These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.","Is the triple ""Valganciclovir prevents cytomegalovirus infection"" supported by the sentence: ""These results suggest that prophylaxis with 900 mg/day of valganciclovir for at least 3 months safely and effectively prevents cytomegalovirus infection in kidney, simultaneous pancreas-kidney and pancreas transplant recipients on highly potent immunosuppression.""?",False, +23156448,Valganciclovir predisposes kidney disorder,2426,"CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?","Is the triple ""Valganciclovir predisposes kidney disorder"" supported by the sentence: ""CMV infection, valganciclovir exposure, and the risk of BK viremia and associated nephropathy after kidney transplantation: Is there a link?""?",False, +20121656,Valganciclovir predisposes cytomegalovirus infection,2427,Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.,"Is the triple ""Valganciclovir predisposes cytomegalovirus infection"" supported by the sentence: ""Under-dosing of valganciclovir is associated with an increased risk of CMV infection and development of ganciclovir-resistant CMV.""?",False, +24607675,Remdesivir prevents adult acute respiratory distress syndrome,2428,Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.,"Is the triple ""Remdesivir prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Combined use of baricitinib (Janus kinase inhibitor) and remdesivir (nucleoside analog) enhances antiviral signaling and viral clearance by SARS-CoV-2-positive monocytes while decreasing secretion of proneutrophilic mediators associated with acute respiratory distress syndrome.""?",False, +18302878,Pixantrone related to Deoxyribonucleic acid,2429,"The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.","Is the triple ""Pixantrone related to Deoxyribonucleic acid"" supported by the sentence: ""The results demonstrate that pixantrone preferentially intercalates at adenine bulge sites, compared to duplex DNA, and predominantly from the minor groove.""?",False, +19964229,Amrubicin affects small cell lung carcinoma,2430,"However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.","Is the triple ""Amrubicin affects small cell lung carcinoma"" supported by the sentence: ""However, the effect of amrubicin-based treatment in extensive-disease (ED) SCLC remains controversial.""?",False, +15413207,Amrubicin disrupts neoplasm,2431,"Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.","Is the triple ""Amrubicin disrupts neoplasm"" supported by the sentence: ""Chemotherapy with amrubicin shrank the tumors, but his muscle weakness did not improve.""?",False, +16523835,Sevoflurane related to delirium,2432,"Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.","Is the triple ""Sevoflurane related to delirium"" supported by the sentence: ""Secondary objectives are to compare the incidence of POD between xenon and sevoflurane, to evaluate the incidence of POD from day 5 post surgery until discharge from hospital, to determine the time to first POD diagnosis, to evaluate the duration of POD, to evaluate the evolution of the physiological status of the patients in the postoperative period, to evaluate the recovery parameters, to collect preliminary data to evaluate the economical impact of POD in the postoperative period and to collect safety data.""?",False, +24969850,Sevoflurane causes adult acute respiratory distress syndrome,2433,This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.,"Is the triple ""Sevoflurane causes adult acute respiratory distress syndrome"" supported by the sentence: ""This study aimed to compare the effectiveness of sevoflurane and propofol on rats with induced ARDS undergoing VV ECMO.""?",False, +24682900,Sevoflurane causes acute kidney failure,2434,The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.,"Is the triple ""Sevoflurane causes acute kidney failure"" supported by the sentence: ""The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism.""?",False, +18232524,Sevoflurane causes Inflammation,2435,"The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.","Is the triple ""Sevoflurane causes Inflammation"" supported by the sentence: ""The results suggest that propofol can effectively attenuate the apoptosis, Abeta accumulation, and inflammation induced by sevoflurane in human neuroglioma cells through NF-kappaB signal pathway.""?",False, +17508909,Sevoflurane causes brain injury,2436,These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.,"Is the triple ""Sevoflurane causes brain injury"" supported by the sentence: ""These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.""?",False, +17459839,Sevoflurane causes ischemia reperfusion injury,2437,"BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).","Is the triple ""Sevoflurane causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).""?",False, +11419059,Sevoflurane causes delirium,2438,"Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.","Is the triple ""Sevoflurane causes delirium"" supported by the sentence: ""Sevoflurane has a propensity to induce 'excitement' during induction of anaesthesia, and delirium in the immediate postoperative phase.""?",False, +7326848,Sevoflurane causes Pain,2439,"Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.","Is the triple ""Sevoflurane causes Pain"" supported by the sentence: ""Haemodynamic parameters (heart rate, mean arterial blood pressure), awakening time (time until the first spontaneous movements occurred), recovery time (according to Aldrete-Score > 8), side-effects (sevoflurane-induced excitation and propofol-induced pain due to the injection during induction of anaesthesia, postoperative vomiting) and costs for anaesthetic agents and relaxants were registered.""?",False, +25308865,Sevoflurane affects neoplasm,2440,"Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.","Is the triple ""Sevoflurane affects neoplasm"" supported by the sentence: ""Propofol, sevoflurane, non-steroidal anti-inflammatory drugs and local anesthetics have shown to exert anti-tumor effect on HCC mainly through regulating microRNAs or signaling pathways, while other inhalational agents, dexmedetomidine and opioids have the potential to promote tumor growth.""?",False, +25006055,Sevoflurane affects Pain,2441,Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.,"Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Repeated exposures to sevoflurane in neonatal rats enhanced the sensitivity to pain and acute traumatic stress response in juvenile life.""?",False, +21710900,Sevoflurane affects obesity disorder,2442,"To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.","Is the triple ""Sevoflurane affects obesity disorder"" supported by the sentence: ""To investigate the effects of obesity on the elimination of desflurane, isoflurane and sevoflurane for various anesthesia durations, the Gas Man(r) computer simulation software was used.""?",False, +18602416,Sevoflurane affects delirium,2443,The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.,"Is the triple ""Sevoflurane affects delirium"" supported by the sentence: ""The present retrospective study was carried out to evaluate whether desflurane or sevoflurane has influence on the incidence of perioperative delirium.""?",False, +17685948,Sevoflurane affects Pain,2444,"Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.","Is the triple ""Sevoflurane affects Pain"" supported by the sentence: ""Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy.""?",False, +17508906,Sevoflurane affects brain injury,2445,We investigated the effects of sevoflurane on EMP-induced brain injury.,"Is the triple ""Sevoflurane affects brain injury"" supported by the sentence: ""We investigated the effects of sevoflurane on EMP-induced brain injury.""?",False, +13563816,Sevoflurane affects Inflammation,2446,The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.,"Is the triple ""Sevoflurane affects Inflammation"" supported by the sentence: ""The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.""?",False, +7303814,Sevoflurane affects ischemia reperfusion injury,2447,"Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.","Is the triple ""Sevoflurane affects ischemia reperfusion injury"" supported by the sentence: ""Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.""?",False, +22571416,Sevoflurane disrupts myocardial infarction,2448,RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.,"Is the triple ""Sevoflurane disrupts myocardial infarction"" supported by the sentence: ""RESULTS: Sef preconditioning reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in myocardial tissues of I/R mice.""?",False, +22138617,Sevoflurane disrupts brain injury,2449,These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.,"Is the triple ""Sevoflurane disrupts brain injury"" supported by the sentence: ""These findings suggest that both 2% isoflurane and 3% sevoflurane significantly inhibited EBI by suppressing post-SAH apoptosis and brain inflammation possibly via the SphK1-related pathway.""?",False, +19949689,Sevoflurane disrupts ischemia reperfusion injury,2450,"New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.","Is the triple ""Sevoflurane disrupts ischemia reperfusion injury"" supported by the sentence: ""New studies have shown that sevoflurane diminishes ischemia/?reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the?occurrence of AKI.""?",False, +17977822,Sevoflurane disrupts Inflammation,2451,Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.,"Is the triple ""Sevoflurane disrupts Inflammation"" supported by the sentence: ""Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.""?",False, +24348187,Sevoflurane prevents acute kidney failure,2452,Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.,"Is the triple ""Sevoflurane prevents acute kidney failure"" supported by the sentence: ""Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.""?",False, +24204877,Sevoflurane prevents neoplasm,2453,"BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.","Is the triple ""Sevoflurane prevents neoplasm"" supported by the sentence: ""BACKGROUND: Recent studies have shown that propofol and sevoflurane, two common anesthetics, can prevent tumor development.""?",False, +20028749,Sevoflurane prevents delirium,2454,Sevoflurane might be beneficial for reducing delirium and POCD.,"Is the triple ""Sevoflurane prevents delirium"" supported by the sentence: ""Sevoflurane might be beneficial for reducing delirium and POCD.""?",False, +19290567,Sevoflurane prevents Pain,2455,"CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.","Is the triple ""Sevoflurane prevents Pain"" supported by the sentence: ""CONCLUSION: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.""?",False, +16830216,Sevoflurane prevents Inflammation,2456,This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.,"Is the triple ""Sevoflurane prevents Inflammation"" supported by the sentence: ""This study aims to investigate the protective effects of sevoflurane on inflammation and ventilator-induced lung injury during mechanical ventilation in healthy mice.""?",False, +11671117,Sevoflurane prevents brain injury,2457,Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.,"Is the triple ""Sevoflurane prevents brain injury"" supported by the sentence: ""Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats.""?",False, +9664903,Sevoflurane prevents ischemia reperfusion injury,2458,BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.,"Is the triple ""Sevoflurane prevents ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Sevoflurane has been shown to protect against myocardial ischemia and reperfusion injury in animals.""?",False, +18320093,Sevoflurane predisposes delirium,2459,"Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.","Is the triple ""Sevoflurane predisposes delirium"" supported by the sentence: ""Here, we test the hypothesis that inhaled anesthetics (IAs), such as Sevoflurane and Isoflurane, act directly on brain vascular endothelial cells (BVECs) to increase blood-brain barrier (BBB) permeability, thereby contributing to POD.""?",False, +18121347,Sevoflurane predisposes Inflammation,2460,Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.,"Is the triple ""Sevoflurane predisposes Inflammation"" supported by the sentence: ""Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil.""?",False, +24455592,Desflurane causes Postoperative Complications,2461,Desflurane resulted in fewer postoperative complications.,"Is the triple ""Desflurane causes Postoperative Complications"" supported by the sentence: ""Desflurane resulted in fewer postoperative complications.""?",False, +16095968,Heroin related to heroin dependence,2462,The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.,"Is the triple ""Heroin related to heroin dependence"" supported by the sentence: ""The impact of diacetylmorphine on hypothalamic-pituitary-adrenal axis activity and heroin craving in heroin dependence.""?",False, +9440915,Heroin related to opiate dependence,2463,"This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.","Is the triple ""Heroin related to opiate dependence"" supported by the sentence: ""This may be of benefit to promote safer and more effective prescribing of diamorphine in opiate dependency, and as an outcome measure in trials of diamorphine prescribing.""?",False, +18531996,Heroin causes heroin dependence,2464,"Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.","Is the triple ""Heroin causes heroin dependence"" supported by the sentence: ""Rats in the addiction groups (20 d, 30 d, 40 d) were all given subcutaneous injection with heroin for 15 days to induce heroin addiction.""?",False, +14784390,Heroin causes opiate dependence,2465,A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.,"Is the triple ""Heroin causes opiate dependence"" supported by the sentence: ""A method to diagnose opioid dependence resulting from heroin versus prescription opioids using the Composite International Diagnostic Interview.""?",False, +19449218,Aluminum hydroxide related to type 1 diabetes mellitus,2466,Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.,"Is the triple ""Aluminum hydroxide related to type 1 diabetes mellitus"" supported by the sentence: ""Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes.""?",False, +19135529,Aluminum hydroxide related to malaria,2467,METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.,"Is the triple ""Aluminum hydroxide related to malaria"" supported by the sentence: ""METHODS: Children 12-60months old were randomized to receive three injections of either 100MUg GMZ2 adjuvanted with aluminum hydroxide or a control vaccine (rabies) four weeks apart and were followed up for six months to measure the incidence of malaria defined as fever or history of fever and a parasite density ?5000/MUL.""?",False, +18758930,Aluminum hydroxide related to influenza,2468,Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.,"Is the triple ""Aluminum hydroxide related to influenza"" supported by the sentence: ""Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.""?",False, +15398111,Aluminum hydroxide prevents stomatitis,2469,This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).,"Is the triple ""Aluminum hydroxide prevents stomatitis"" supported by the sentence: ""This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM).""?",False, +15812884,Methadone related to heroin dependence,2470,Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.,"Is the triple ""Methadone related to heroin dependence"" supported by the sentence: ""Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction.""?",False, +19260564,Methadone causes neonatal abstinence syndrome,2471,"Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.","Is the triple ""Methadone causes neonatal abstinence syndrome"" supported by the sentence: ""Methadone and buprenorphine were frequently seen negatively because they ""caused"" neonatal abstinence syndrome.""?",False, +18130331,Methadone causes neuralgia,2472,We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.,"Is the triple ""Methadone causes neuralgia"" supported by the sentence: ""We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (>10 mg/kg/day) due to vincristine-induced neuropathy where surgical procedures provoked severe neuropathic pain.""?",False, +18100345,Methadone causes Pain,2473,Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.,"Is the triple ""Methadone causes Pain"" supported by the sentence: ""Many participants experienced painful withdrawal from methadone during incarceration and were fearful that using MAT would lead to opioid tolerance and painful withdrawal again in the future.""?",False, +21405277,Methadone affects opiate dependence,2474,"Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).","Is the triple ""Methadone affects opiate dependence"" supported by the sentence: ""Unlike N-desmethyl-1-alpha-acetylmethadol (NLAAM), a single injection of methadone (METH), near domestic chicken embryos early during development, cannot induce and sustain opioid-type dependence in the older embryo (i.e., days 14-17 of development).""?",False, +21075382,Methadone affects neoplasm,2475,The analgesic drug methadone is able to sensitize various tumors to chemotherapy.,"Is the triple ""Methadone affects neoplasm"" supported by the sentence: ""The analgesic drug methadone is able to sensitize various tumors to chemotherapy.""?",False, +20010980,Methadone affects Premature birth,2476,They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.,"Is the triple ""Methadone affects Premature birth"" supported by the sentence: ""They found that the decreases in risk of preterm birth and length of infant hospitalization associated with buprenorphine as compared with methadone were attenuated after accounting for the additional confounding.""?",False, +18302283,Methadone affects Pain,2477,"There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.","Is the triple ""Methadone affects Pain"" supported by the sentence: ""There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexone, and levomethadyl acetate (LAAM), of which the mediating effects of pain on treatment attrition, substance use behavior, and social functioning may differ across therapies.""?",False, +18207522,Methadone affects neonatal abstinence syndrome,2478,"The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.","Is the triple ""Methadone affects neonatal abstinence syndrome"" supported by the sentence: ""The mechanism of this beneficial effect of breast milk on NAS remains unclear, as the negligible amount of methadone transmitted via breast milk is unlikely to have an impact on NAS.""?",False, +18078354,Methadone affects cocaine dependence,2479,"Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.","Is the triple ""Methadone affects cocaine dependence"" supported by the sentence: ""Fractioned methadone intake (odds ratio 4.87, 95% confidence interval 1.27-18.6, P = 0.02), bodyweight (odds ratio 1.57, 95% confidence interval 1.01-2.44, P = 0.04), history of cocaine dependence (80 vs. 44 mg day(-1) in never-addict patients, P = 0.005) and ethnicity (Asian > Caucasian > African, P = 0.04) were independently associated with high-dose methadone in multiple regression analysis.""?",False, +11558529,Methadone affects HIV infectious disease,2480,"OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.","Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""OBJECTIVE: We determined pneumonia, endocarditis, hospitalizations and death rates in a group of HIV-infected and non-infected IVDU recruited at low-threshold methadone programmes in Amsterdam, The Netherlands to examine the influence of HIV infection on morbidity and non-AIDS mortality in intravenous drug users (IVDU) without AIDS.""?",False, +9289228,Methadone affects HIV infectious disease,2481,Methadone enhances human immunodeficiency virus infection of human immune cells.,"Is the triple ""Methadone affects HIV infectious disease"" supported by the sentence: ""Methadone enhances human immunodeficiency virus infection of human immune cells.""?",False, +8979183,Methadone affects neuralgia,2482,Studies are on going to assess the potential role of methadone in treating neuropathic pain.,"Is the triple ""Methadone affects neuralgia"" supported by the sentence: ""Studies are on going to assess the potential role of methadone in treating neuropathic pain.""?",False, +16059875,Methadone disrupts neonatal abstinence syndrome,2483,"Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.","Is the triple ""Methadone disrupts neonatal abstinence syndrome"" supported by the sentence: ""Finally, recent advances in the treatment of opioid-dependent pregnant women have suggested buprenorphine as an alternative treatment to methadone during pregnancy, largely due to reduced NAS severity in exposed neonates.""?",False, +10769844,Methadone disrupts Pain,2484,"However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.","Is the triple ""Methadone disrupts Pain"" supported by the sentence: ""However, naloxone pre-treatment also antagonized an inhibitory effect of methadone on the pain generated by a 7-second pulse of 45 degrees C heat.""?",False, +17766557,Methadone prevents hepatitis C virus infection,2485,There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.,"Is the triple ""Methadone prevents hepatitis C virus infection"" supported by the sentence: ""There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.""?",False, +15264750,Methadone prevents opiate dependence,2486,Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.,"Is the triple ""Methadone prevents opiate dependence"" supported by the sentence: ""Maintenance therapy with methadone or buprenorphine-based regimens reduces opioid dependence and associated harms.""?",False, +8905283,Methadone prevents Pain,2487,"In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.","Is the triple ""Methadone prevents Pain"" supported by the sentence: ""In addition to aspirin or acetaminophen, four drugs--amitriptyline, diphenylhydantoin, cobra venom extract and methadone--are used to reduce pain while other therapeutic measures are used to rehabilitate the patients.""?",False, +8022918,Methadone prevents neonatal abstinence syndrome,2488,Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.,"Is the triple ""Methadone prevents neonatal abstinence syndrome"" supported by the sentence: ""Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.""?",False, +26487110,Methadone predisposes HIV infectious disease,2489,"A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.","Is the triple ""Methadone predisposes HIV infectious disease"" supported by the sentence: ""A large body of literature--including some well designed studies--indicates that methadone reduces heroin use, mortality, criminal activity and risk of human immunodeficiency virus (HIV) infection.""?",False, +15424591,Methadone predisposes neonatal abstinence syndrome,2490,CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.,"Is the triple ""Methadone predisposes neonatal abstinence syndrome"" supported by the sentence: ""CONCLUSIONS: Quantitative methadone and EDDP measurement may predict NAS severity.""?",False, +14491460,Methadone predisposes Premature birth,2491,"CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.","Is the triple ""Methadone predisposes Premature birth"" supported by the sentence: ""CONCLUSION: The PTB rate among women on methadone (29.1%) is nearly 3 times the national average (11.1%), and those abusing 2 or more supplements to methadone are at further increased risk for PTB.""?",False, +26386166,Levomethadyl acetate causes opiate dependence,2492,"Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.","Is the triple ""Levomethadyl acetate causes opiate dependence"" supported by the sentence: ""Repeated oral administration of 0.2, 0.5 or 2.0 mg of LAAM per kg to mature female rats for 21 days resulted in diminished weight gain and was sufficient to induce opiate dependence.""?",False, +26901861,Halofantrine prevents malaria,2493,Postexposure administration of halofantrine for the prevention of malaria.,"Is the triple ""Halofantrine prevents malaria"" supported by the sentence: ""Postexposure administration of halofantrine for the prevention of malaria.""?",False, +27668107,Erythropoietin related to HIV infectious disease,2494,"Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.","Is the triple ""Erythropoietin related to HIV infectious disease"" supported by the sentence: ""Although we cannot rule out a treatment selection bias, adjusting for available prognostic factors and factors potentially associated with a decision to use erythropoietin suggests that erythropoietin for treatment of anemia is associated with improved survival in HIV disease.""?",False, +24695634,Erythropoietin related to optic nerve disorder,2495,Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.,"Is the triple ""Erythropoietin related to optic nerve disorder"" supported by the sentence: ""Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.""?",False, +21186290,Erythropoietin related to Premature birth,2496,"To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.","Is the triple ""Erythropoietin related to Premature birth"" supported by the sentence: ""To address this therapeutic opportunity, we conducted a prospective clinical study to investigate the PK of Epo in very-low-birth-weight (VLBW) premature neonates using a unique Epo dosing algorithm that accounts for complex neonatal erythropoietic physiology.""?",False, +20871066,Erythropoietin related to necrotizing enterocolitis,2497,"The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.","Is the triple ""Erythropoietin related to necrotizing enterocolitis"" supported by the sentence: ""The roles of glucagon-like peptide 2, insulin-like growth factor 1, erythropoietin, growth hormone, and hepatocyte growth factor in necrotizing enterocolitis are summarized in this article.""?",False, +18130124,Erythropoietin related to mood disorder,2498,Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.,"Is the triple ""Erythropoietin related to mood disorder"" supported by the sentence: ""Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.""?",False, +17186873,Erythropoietin related to ST-elevation myocardial infarction,2499,High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.,"Is the triple ""Erythropoietin related to ST-elevation myocardial infarction"" supported by the sentence: ""High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.""?",False, +16980950,Erythropoietin related to acute myeloid leukemia,2500,The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.,"Is the triple ""Erythropoietin related to acute myeloid leukemia"" supported by the sentence: ""The effect of erythropoietin (Epo) on colony formation by blast progenitors in acute myeloblastic leukaemia other than erythroleukaemia was studied using a blast colony assay.""?",False, +16468663,Erythropoietin related to optic neuritis,2501,"A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.","Is the triple ""Erythropoietin related to optic neuritis"" supported by the sentence: ""A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.""?",False, +16173384,Erythropoietin related to Friedreich ataxia,2502,Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.,"Is the triple ""Erythropoietin related to Friedreich ataxia"" supported by the sentence: ""Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.""?",False, +15054484,Erythropoietin related to breast neoplasm,2503,"EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.","Is the triple ""Erythropoietin related to breast neoplasm"" supported by the sentence: ""EPO receptor (EPOR) messenger RNA (mRNA) was detectable in both B16F10 tumors and mammary tumors from MMTV-PyMT mice but was 0.12 +/- 0.02% and 1.3 +/- 0.91% of the EPOR mRNA level in murine erythroid HCD-57 cells, respectively.""?",False, +14004775,Erythropoietin related to malaria,2504,"To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.","Is the triple ""Erythropoietin related to malaria"" supported by the sentence: ""To gain insight into potential relationships between tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), erythropoietin (EPO), and anemia in acute malaria, 90 children 3 to 11 years with acute malaria were studied.""?",False, +13955435,Erythropoietin related to chronic renal failure syndrome,2505,[Erythropoietin in the treatment of anemia in chronic renal insufficiency].,"Is the triple ""Erythropoietin related to chronic renal failure syndrome"" supported by the sentence: ""[Erythropoietin in the treatment of anemia in chronic renal insufficiency].""?",False, +13624052,Erythropoietin related to stroke disorder,2506,"Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.","Is the triple ""Erythropoietin related to stroke disorder"" supported by the sentence: ""Using doses of erythropoietin and darbepoetin that other investigators have reported to be beneficial in SCI and stroke models, we were unable to demonstrate a neuroprotective effect when administered 1 h after injury.""?",False, +13580694,Erythropoietin related to Fatigue,2507,Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).,"Is the triple ""Erythropoietin related to Fatigue"" supported by the sentence: ""Erythropoietin showed a small but significant improvement in fatigue (for anaemic patients receiving chemotherapy) compared to placebo (Z = 2.67; P = 0.008).""?",False, +13206114,Erythropoietin related to sickle cell anemia,2508,Erythropoietin for anemia of renal failure in sickle cell disease.,"Is the triple ""Erythropoietin related to sickle cell anemia"" supported by the sentence: ""Erythropoietin for anemia of renal failure in sickle cell disease.""?",False, +12496787,Erythropoietin related to subarachnoid hemorrhage,2509,Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.,"Is the triple ""Erythropoietin related to subarachnoid hemorrhage"" supported by the sentence: ""Endothelial nitric oxide-mediated Nrf2 activation as a novel mechanism for vascular and neuroprotection by erythropoietin in experimental subarachnoid hemorrhage.""?",False, +12188394,Erythropoietin related to Parkinson disease,2510,"These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.","Is the triple ""Erythropoietin related to Parkinson disease"" supported by the sentence: ""These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease.""?",False, +12126135,Erythropoietin related to spinal cord injury,2511,We determined whether EPO and MPSS act synergistically in SCI.,"Is the triple ""Erythropoietin related to spinal cord injury"" supported by the sentence: ""We determined whether EPO and MPSS act synergistically in SCI.""?",False, +11923140,Erythropoietin related to acute kidney failure,2512,Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.,"Is the triple ""Erythropoietin related to acute kidney failure"" supported by the sentence: ""Erythropoietin in thrombotic thrombocytopenic purpura and acute renal failure.""?",False, +11799479,Erythropoietin related to myocardial infarction,2513,A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.,"Is the triple ""Erythropoietin related to myocardial infarction"" supported by the sentence: ""A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release.""?",False, +11734187,Erythropoietin related to multiple sclerosis,2514,Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.,"Is the triple ""Erythropoietin related to multiple sclerosis"" supported by the sentence: ""Our findings suggest that further studies are warranted to evaluate the use of EPO in minimizing acute relapses in MS.""?",False, +11580074,Erythropoietin related to ischemia reperfusion injury,2515,We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.,"Is the triple ""Erythropoietin related to ischemia reperfusion injury"" supported by the sentence: ""We determined the role of JAK/STAT and Ras/Rac/MAPK in the protective effect of EPO against ischemia-reperfusion injury in infant rabbit heart.""?",False, +11529882,Erythropoietin related to myocardial ischemia,2516,"To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.","Is the triple ""Erythropoietin related to myocardial ischemia"" supported by the sentence: ""To evaluate the protective role of EPO in cardiac ischemia, we performed low-flow (0.6 ml/min) ischemia/reperfusion experiments in isolated rat hearts.""?",False, +11452051,Erythropoietin related to prostate cancer,2517,These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.,"Is the triple ""Erythropoietin related to prostate cancer"" supported by the sentence: ""These experiments revealed the expression of both erythropoietin receptor and erythropoietin in LNCaP and PC-3 cells suggesting that these prostate cancer cell lines may serve as useful experimental models for further studies of erythropoietin and erythropoietin receptor function in prostate cancer.""?",False, +11316441,Erythropoietin related to Ischemic stroke,2518,The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.,"Is the triple ""Erythropoietin related to Ischemic stroke"" supported by the sentence: ""The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.""?",False, +11293850,Erythropoietin related to amyotrophic lateral sclerosis,2519,"Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.","Is the triple ""Erythropoietin related to amyotrophic lateral sclerosis"" supported by the sentence: ""Although further studies of functional features of Epo in ALS are needed, the first demonstration of increased immunoreactivity for Epo in the CNS of SOD1(G93A) transgenic mice may provide initial insights into the development of interventional strategies to alleviate motor neuron degeneration in human ALS.""?",False, +10879812,Erythropoietin related to hepatitis C virus infection,2520,Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.,"Is the triple ""Erythropoietin related to hepatitis C virus infection"" supported by the sentence: ""Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions.""?",False, +10348029,Erythropoietin related to neoplasm,2521,We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.,"Is the triple ""Erythropoietin related to neoplasm"" supported by the sentence: ""We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis.""?",False, +9392178,Erythropoietin related to injury,2522,Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.,"Is the triple ""Erythropoietin related to injury"" supported by the sentence: ""Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.""?",False, +9089666,Erythropoietin related to chronic myelomonocytic leukemia,2523,Response to erythropoietin in chronic myelomonocytic leukaemia.,"Is the triple ""Erythropoietin related to chronic myelomonocytic leukemia"" supported by the sentence: ""Response to erythropoietin in chronic myelomonocytic leukaemia.""?",False, +8164061,Erythropoietin related to myelodysplastic syndrome,2524,"We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.","Is the triple ""Erythropoietin related to myelodysplastic syndrome"" supported by the sentence: ""We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.""?",False, +7458321,Erythropoietin related to brain ischemia,2525,A potential role for erythropoietin in focal permanent cerebral ischemia in mice.,"Is the triple ""Erythropoietin related to brain ischemia"" supported by the sentence: ""A potential role for erythropoietin in focal permanent cerebral ischemia in mice.""?",False, +7310369,Erythropoietin related to anemia,2526,"The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.","Is the triple ""Erythropoietin related to anemia"" supported by the sentence: ""The association of anemia and hyporeninemic hypoaldosteronism (HRHA) in type 1 diabetes has been described, and erythropoietin deficiency has been proposed as the cause.""?",False, +7231907,Erythropoietin related to chronic kidney disease,2527,Drug usage evaluation of epoetin in chronic renal failure.,"Is the triple ""Erythropoietin related to chronic kidney disease"" supported by the sentence: ""Drug usage evaluation of epoetin in chronic renal failure.""?",False, +7137476,Erythropoietin related to kidney failure,2528,This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.,"Is the triple ""Erythropoietin related to kidney failure"" supported by the sentence: ""This paper summarises the benefits and risks of r-hu-EPO administered in renal insufficiency.""?",False, +12479345,Erythropoietin has part myelodysplastic syndrome,2529,"An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.","Is the triple ""Erythropoietin has part myelodysplastic syndrome"" supported by the sentence: ""An open-label, phase II non-randomised trial was conducted with darbepoetin (DAR), an erythropoiesis-stimulating factor with prolonged half-life, at a weekly dose of 300 mug subcutaneously in 62 anaemic patients with myelodysplastic syndrome (MDS) with an endogenous erythropoietin (EPO) level <500 mU/ml.""?",False, +9398172,Erythropoietin has part neoplasm,2530,"Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.","Is the triple ""Erythropoietin has part neoplasm"" supported by the sentence: ""Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.""?",False, +27259307,Erythropoietin causes acute kidney failure,2531,"To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.","Is the triple ""Erythropoietin causes acute kidney failure"" supported by the sentence: ""To study the role of erythropoietin (Epo) in the pathogenesis of anemia in acute renal failure (ARF), organ Epo mRNA was measured by RNase protection assay in rats with ARF induced by a one hour-occlusion of the left renal artery.""?",False, +20985522,Erythropoietin causes ischemia reperfusion injury,2532,"RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.","Is the triple ""Erythropoietin causes ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In vivo, EPO remarkably attenuated pulmonary interstitial and alveolar epithelial edema caused by renal IR injury.""?",False, +19282478,Erythropoietin causes neoplasm,2533,"Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.","Is the triple ""Erythropoietin causes neoplasm"" supported by the sentence: ""Furthermore, to explore the therapeutic targeting of EPO-induced tumor changes, we found that blocking EPO signaling with soluble EPO receptor extracellular domain Fc fusion protein could inhibit tumor growth both in vitro and in vivo.""?",False, +19178150,Erythropoietin causes spinal cord injury,2534,"AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.","Is the triple ""Erythropoietin causes spinal cord injury"" supported by the sentence: ""AIM: The aim of this study was to compare the preventive effects of Etanercept, Etomidate, Erythropoietin and their combination in experimentally induced spinal cord trauma by clinical, histopathological, electrophysiological parameters and biochemical examination.""?",False, +18508111,Erythropoietin causes Parkinson disease,2535,"The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.","Is the triple ""Erythropoietin causes Parkinson disease"" supported by the sentence: ""The present study was aimed at clarifying whether combined treatment with CEF and EPO (CEF+EPO) had superior neuroprotective and behavioral effects than treatment with CEF or EPO alone in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model.""?",False, +16355442,Erythropoietin causes brain ischemia,2536,"Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.","Is the triple ""Erythropoietin causes brain ischemia"" supported by the sentence: ""Several potentially detrimental side-effects of EPO therapy, such as increased risk of thrombosis, cancer, increased metabolic rate and mean arterial blood pressure leading to cerebral ischemia could severely limit or halt the use of EPO.""?",False, +15387266,Erythropoietin causes stroke disorder,2537,Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.,"Is the triple ""Erythropoietin causes stroke disorder"" supported by the sentence: ""Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.""?",False, +13935957,Erythropoietin causes injury,2538,OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.,"Is the triple ""Erythropoietin causes injury"" supported by the sentence: ""OBJECTIVE: To investigate whether erythropoietin (EPO) protects neuron against ketamine induced injuries.""?",False, +12824447,Erythropoietin causes chronic kidney disease,2539,"BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.","Is the triple ""Erythropoietin causes chronic kidney disease"" supported by the sentence: ""BACKGROUND: Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency.""?",False, +11912976,Erythropoietin causes myocardial infarction,2540,"Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).","Is the triple ""Erythropoietin causes myocardial infarction"" supported by the sentence: ""Rats with MI were randomly assigned to: untreated (MI), a single bolus of EPO immediately after MI induction (MI-EPO-early), EPO treatment immediately after MI and once every three weeks (MI-EPO-early+late), and EPO treatment starting three weeks after induction of MI, once every three weeks (MI-EPO-late).""?",False, +11763164,Erythropoietin causes Fatigue,2541,"The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.","Is the triple ""Erythropoietin causes Fatigue"" supported by the sentence: ""The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.""?",False, +9672360,Erythropoietin causes kidney failure,2542,"Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.","Is the triple ""Erythropoietin causes kidney failure"" supported by the sentence: ""Anemia and EPO levels were not affected by gender, body mass index, cause of renal failure, residual renal function, HD dose, protein catabolic rate, use of different heparins or dialysate buffers, ACE inhibitor therapy, and parathyroid or thyroid function.""?",False, +9370139,Erythropoietin causes subarachnoid hemorrhage,2543,"A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).","Is the triple ""Erythropoietin causes subarachnoid hemorrhage"" supported by the sentence: ""A subcutaneous injection of EPO given immediately after the induction of SAH normalized autoregulation of CBF (lower limit in group D: 93+/-4 mmHg, NS compared with groups A and B).""?",False, +8009177,Erythropoietin causes anemia,2544,Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.,"Is the triple ""Erythropoietin causes anemia"" supported by the sentence: ""Current guidelines suggest that anaemia due to erythropoietin deficiency almost exclusively occurs with creatinine concentrations of at least 177 micromol/l or above.""?",False, +26962810,Erythropoietin affects HIV infectious disease,2545,These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.,"Is the triple ""Erythropoietin affects HIV infectious disease"" supported by the sentence: ""These results suggest that impaired production of Epo may be a direct effect of HIV-1 infection possibly contributing to anemia in AIDS.""?",False, +26278974,Erythropoietin affects sickle cell anemia,2546,These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.,"Is the triple ""Erythropoietin affects sickle cell anemia"" supported by the sentence: ""These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.""?",False, +24983690,Erythropoietin affects acute myeloid leukemia,2547,We conclude that both erythropoietin and BPA are appropriately increased in ANLL.,"Is the triple ""Erythropoietin affects acute myeloid leukemia"" supported by the sentence: ""We conclude that both erythropoietin and BPA are appropriately increased in ANLL.""?",False, +20885392,Erythropoietin affects ST-elevation myocardial infarction,2548,Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).,"Is the triple ""Erythropoietin affects ST-elevation myocardial infarction"" supported by the sentence: ""Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI).""?",False, +20610677,Erythropoietin affects stroke disorder,2549,"In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.","Is the triple ""Erythropoietin affects stroke disorder"" supported by the sentence: ""In the present study, we investigated the effects of local intra-arterial infusion of low-dose EPO in combination with tPA on focal cerebral ischemic stroke.""?",False, +18390137,Erythropoietin affects chronic kidney disease,2550,The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients.""?",False, +18352546,Erythropoietin affects injury,2551,Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.,"Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Local expression of both EPO and its receptor is upregulated upon injury or stress and plays a role in tissue homeostasis and cytoprotection.""?",False, +17607901,Erythropoietin affects necrotizing enterocolitis,2552,The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.,"Is the triple ""Erythropoietin affects necrotizing enterocolitis"" supported by the sentence: ""The rates for mortality and morbidities including intraventricular haemorrhage and necrotizing enterocolitis were not significantly changed by early EPO treatment.""?",False, +15862945,Erythropoietin affects Ischemic stroke,2553,"To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.","Is the triple ""Erythropoietin affects Ischemic stroke"" supported by the sentence: ""To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke.""?",False, +15862785,Erythropoietin affects malaria,2554,"CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.","Is the triple ""Erythropoietin affects malaria"" supported by the sentence: ""CONCLUSIONS: Although EPO levels increase according to malaria severity and are higher in severe malaria than in bacteremia, the utility of EPO to distinguish malaria-attributable severe disease is limited due to the overlap of values between the study groups and the main role of hemoglobin in the expression of EPO.""?",False, +15728394,Erythropoietin affects myocardial infarction,2555,"Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Over the past 5-10 years, the positive effects of erythropoietin on myocardial infarction have been reported in several experimental, animal models.""?",False, +15532613,Erythropoietin affects myocardial infarction,2556,"Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.","Is the triple ""Erythropoietin affects myocardial infarction"" supported by the sentence: ""Moreover, both pretreatment and posttreatment of EPO decreased the EPO receptor messenger RNA and protein expressions, which were up-regulated in MI.""?",False, +12937865,Erythropoietin affects anemia,2557,"CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.","Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""CONCLUSION: Epoetin alfa can play an important role in managing anemia in critical care patients, thereby minimizing patient exposure to transfusion-related risks and optimizing the use of the limited blood supply.""?",False, +12867407,Erythropoietin affects myocardial ischemia,2558,Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.,"Is the triple ""Erythropoietin affects myocardial ischemia"" supported by the sentence: ""Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.""?",False, +11701568,Erythropoietin affects Fatigue,2559,"This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.","Is the triple ""Erythropoietin affects Fatigue"" supported by the sentence: ""This randomized, double-blind, placebo-controlled pilot trial assessed the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood, and evaluated its effects on fatigue and QOL in patients with breast cancer treated with anthracycline-based adjuvant or neoadjuvant chemotherapy.""?",False, +11563361,Erythropoietin affects neoplasm,2560,"Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.","Is the triple ""Erythropoietin affects neoplasm"" supported by the sentence: ""Overall, these preclinical findings suggest that correction of anemia by rHuEPO can increase tumor sensitivity to both radiation therapy and chemotherapy and that epoetin alfa may exert an immunomodulatory effect in multiple myeloma.""?",False, +10970912,Erythropoietin affects brain injury,2561,BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.,"Is the triple ""Erythropoietin affects brain injury"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity.""?",False, +10068762,Erythropoietin affects injury,2562,"Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.","Is the triple ""Erythropoietin affects injury"" supported by the sentence: ""Signaling through the EPO receptor, however, remains biologically responsive to exogenous EPO administration to offer significant protection against nitric oxide-induced injury.""?",False, +9989127,Erythropoietin affects ischemia reperfusion injury,2563,OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.,"Is the triple ""Erythropoietin affects ischemia reperfusion injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to show the effect of erythropoietin on ischemia-reperfusion-induced oxidative damage in fetal rat brain.""?",False, +9392180,Erythropoietin affects spinal cord injury,2564,These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.,"Is the triple ""Erythropoietin affects spinal cord injury"" supported by the sentence: ""These observations suggest both an acute as well as a delayed beneficial action of rHu-EPO in ischemic spinal cord injury.""?",False, +8981317,Erythropoietin affects brain ischemia,2565,"When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.","Is the triple ""Erythropoietin affects brain ischemia"" supported by the sentence: ""When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia.""?",False, +7400221,Erythropoietin affects chronic kidney disease,2566,Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.,"Is the triple ""Erythropoietin affects chronic kidney disease"" supported by the sentence: ""Epoetin treatment may delay the progression of chronic renal failure (CRF) in paediatric patients.""?",False, +7278560,Erythropoietin affects anemia,2567,Erythropoietin elevation in anemia of thermal injury.,"Is the triple ""Erythropoietin affects anemia"" supported by the sentence: ""Erythropoietin elevation in anemia of thermal injury.""?",False, +27259305,Erythropoietin produces acute kidney failure,2568,Erythropoietin production in rats with post-ischemic acute renal failure.,"Is the triple ""Erythropoietin produces acute kidney failure"" supported by the sentence: ""Erythropoietin production in rats with post-ischemic acute renal failure.""?",False, +26811591,Erythropoietin produces HIV infectious disease,2569,The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.,"Is the triple ""Erythropoietin produces HIV infectious disease"" supported by the sentence: ""The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production.""?",False, +26231858,Erythropoietin produces lymphoma,2570,Renal lymphosarcoma with inappropriate erythropoietin production in a dog.,"Is the triple ""Erythropoietin produces lymphoma"" supported by the sentence: ""Renal lymphosarcoma with inappropriate erythropoietin production in a dog.""?",False, +14673419,Erythropoietin produces myocardial infarction,2571,Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.,"Is the triple ""Erythropoietin produces myocardial infarction"" supported by the sentence: ""Increased erythropoietin production in patients with myocardial infarction was caused by blood hypoxia under conditions of keeping kidney erythropoietin function.""?",False, +11452049,Erythropoietin produces prostate cancer,2572,"To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.","Is the triple ""Erythropoietin produces prostate cancer"" supported by the sentence: ""To determine whether monolayer cultures of continuous cell lines derived from prostate cancer also express erythropoietin receptor and erythropoietin, we studied well-characterized hormone-responsive (LNCaP) and hormone-refractory (PC-3) prostate cancer cell lines.""?",False, +8829207,Erythropoietin produces neoplasm,2573,The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.,"Is the triple ""Erythropoietin produces neoplasm"" supported by the sentence: ""The mechanisms proposed to explain polycythemia in such a tumor were revised and our conclusion is that the tumor produced the erythropoietin autonomously and is not subjected to feedback control mechanism.""?",False, +8032421,Erythropoietin produces chronic renal failure syndrome,2574,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic renal failure syndrome"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, +8032418,Erythropoietin produces chronic kidney disease,2575,"Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.","Is the triple ""Erythropoietin produces chronic kidney disease"" supported by the sentence: ""Anemia of end-stage chronic renal insufficiency (ESRD) is only one among its many complications and has complex pathogenesis; one of the primary factors causing anemia is insufficient production of erythropoietin, a leading factor in the production of erythropoiesis.""?",False, +7919214,Erythropoietin produces anemia,2576,"The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.","Is the triple ""Erythropoietin produces anemia"" supported by the sentence: ""The erythropoietic response to anemia is blunted, probably as a consequence of an inappropriate increase in erythropoietin production and diminished iron availability.""?",False, +7844664,Erythropoietin produces kidney failure,2577,Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.,"Is the triple ""Erythropoietin produces kidney failure"" supported by the sentence: ""Main mechanisms involved in the development of chemotherapy-induced anemia are the direct bone marrow damage and the renal impairment with a secondary deficient production of erythropoietin.""?",False, +17835656,Erythropoietin disrupts brain injury,2578,"CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.","Is the triple ""Erythropoietin disrupts brain injury"" supported by the sentence: ""CONCLUSIONS AND RELEVANCE: In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI.""?",False, +17602040,Erythropoietin disrupts Hemorrhage,2579,"CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.","Is the triple ""Erythropoietin disrupts Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.""?",False, +17384804,Erythropoietin disrupts Ischemic stroke,2580,"Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.","Is the triple ""Erythropoietin disrupts Ischemic stroke"" supported by the sentence: ""Inhibition of PHD activity resulted in HIF-1alpha stabilization, increased expression of VEGF and Epo, improved outcome from ischemic stroke and reduced edema formation by maintaining BBB integrity.""?",False, +15027834,Erythropoietin disrupts Fatigue,2581,"In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.","Is the triple ""Erythropoietin disrupts Fatigue"" supported by the sentence: ""In a large dose, EPO crosses the BBB and may reduce central fatigue and improve cognition.""?",False, +13243471,Erythropoietin disrupts chronic kidney disease,2582,"Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).","Is the triple ""Erythropoietin disrupts chronic kidney disease"" supported by the sentence: ""Erythropoietin (EPO) is a haematopoietic cytokine, mainly generated in the renal cortex, and its secretion and action is impaired in chronic kidney disease (CKD).""?",False, +13033535,Erythropoietin disrupts amyotrophic lateral sclerosis,2583,Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.,"Is the triple ""Erythropoietin disrupts amyotrophic lateral sclerosis"" supported by the sentence: ""Low CSF EPO in ALS may imply that the EPO-associated capacity to protect neurons from degeneration is impaired in ALS.""?",False, +11253087,Erythropoietin disrupts injury,2584,"Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.","Is the triple ""Erythropoietin disrupts injury"" supported by the sentence: ""Administration of EPO (300 IU/kg i.v., n = 10) before resuscitation abolished the renal dysfunction and liver injury in hemorrhagic, but not endotoxic, shock.""?",False, +8818732,Erythropoietin disrupts anemia,2585,"Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.","Is the triple ""Erythropoietin disrupts anemia"" supported by the sentence: ""Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients.""?",False, +22124183,Erythropoietin prevents Premature birth,2586,Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.,"Is the triple ""Erythropoietin prevents Premature birth"" supported by the sentence: ""Erythropoietin Prevents LPS-Induced Preterm Birth and Increases Offspring Survival.PROBLEM: Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children.""?",False, +19522952,Erythropoietin prevents Asphyxia,2587,OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.,"Is the triple ""Erythropoietin prevents Asphyxia"" supported by the sentence: ""OBJECTIVE: Erythropoietin (EPO) is neuroprotective after asphyxia in animal studies.""?",False, +17246645,Erythropoietin prevents cerebral palsy,2588,"We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.","Is the triple ""Erythropoietin prevents cerebral palsy"" supported by the sentence: ""We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.""?",False, +16915551,Erythropoietin prevents coronary artery disorder,2589,"Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.","Is the triple ""Erythropoietin prevents coronary artery disorder"" supported by the sentence: ""Because HBSP does not have the prothrombotic effects of EPO, our study may provide a novel therapeutic strategy that prevents progression of coronary artery disease.""?",False, +16468664,Erythropoietin prevents optic neuritis,2590,INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.,"Is the triple ""Erythropoietin prevents optic neuritis"" supported by the sentence: ""INTERPRETATION: These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.""?",False, +16040441,Erythropoietin prevents spinal cord injury,2591,This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.,"Is the triple ""Erythropoietin prevents spinal cord injury"" supported by the sentence: ""This study aimed to determine the neuron protective effect of erythropoietin on spinal cord injury (SCI) by assessing C/EBP-homologous protein (CHOP) in the development of a rat model of SCI.""?",False, +15444373,Erythropoietin prevents Parkinson disease,2592,"In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.","Is the triple ""Erythropoietin prevents Parkinson disease"" supported by the sentence: ""In conclusion, the present study demonstrates that a brain penetrating form of EPO is neuroprotective in PD following IV administration with minimal effects on erythropoiesis.""?",False, +14252439,Erythropoietin prevents kidney failure,2593,"The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.","Is the triple ""Erythropoietin prevents kidney failure"" supported by the sentence: ""The results obtained have shown that epoetin alfa significantly reduced the functional renal failures and renal damages, and increased toleration of high doses of cisplatin.""?",False, +13347324,Erythropoietin prevents subarachnoid hemorrhage,2594,BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.,"Is the triple ""Erythropoietin prevents subarachnoid hemorrhage"" supported by the sentence: ""BACKGROUND: Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke.""?",False, +13017739,Erythropoietin prevents chronic kidney disease,2595,[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].,"Is the triple ""Erythropoietin prevents chronic kidney disease"" supported by the sentence: ""[Erythropoietins and haemoglobin targets to prevent the progression of chronic kidney disease: guideline from the Italian Society of Nephrology].""?",False, +11480928,Erythropoietin prevents Ischemic stroke,2596,"Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.","Is the triple ""Erythropoietin prevents Ischemic stroke"" supported by the sentence: ""Like EPO, CEPO is neuroprotective in a wide range of animal models of neurotoxicity: middle cerebral artery occlusion model of ischaemic stroke, sciatic nerve compression, spinal cord depression, experimental autoimmune encephalomyelitis and peripheral diabetic neuropathy.""?",False, +11148609,Erythropoietin prevents myocardial ischemia,2597,"Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.","Is the triple ""Erythropoietin prevents myocardial ischemia"" supported by the sentence: ""Erythropoietin is protective against cardiac ischemia, but the underlying mechanisms are unknown.""?",False, +11115141,Erythropoietin prevents stroke disorder,2598,"Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.","Is the triple ""Erythropoietin prevents stroke disorder"" supported by the sentence: ""Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke.""?",False, +10838253,Erythropoietin prevents necrotizing enterocolitis,2599,Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.,"Is the triple ""Erythropoietin prevents necrotizing enterocolitis"" supported by the sentence: ""Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.""?",False, +10766440,Erythropoietin prevents myocardial infarction,2600,Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.,"Is the triple ""Erythropoietin prevents myocardial infarction"" supported by the sentence: ""Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats.""?",False, +10125087,Erythropoietin prevents ischemia reperfusion injury,2601,"HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.","Is the triple ""Erythropoietin prevents ischemia reperfusion injury"" supported by the sentence: ""HIF-1-related gene expression, such as erythropoietin or VEGF, results in protection of ischemia reperfusion injury.""?",False, +8434315,Erythropoietin prevents injury,2602,"In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.","Is the triple ""Erythropoietin prevents injury"" supported by the sentence: ""In confirmation of this hypothesis, systemic administration of r-Hu-EPO before or up to 6 h after focal brain ischemia reduced injury by approximately 50-75%.""?",False, +8405867,Erythropoietin prevents brain ischemia,2603,Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.,"Is the triple ""Erythropoietin prevents brain ischemia"" supported by the sentence: ""Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.""?",False, +8369017,Erythropoietin prevents brain injury,2604,Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.,"Is the triple ""Erythropoietin prevents brain injury"" supported by the sentence: ""Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.""?",False, +7400218,Erythropoietin prevents Fatigue,2605,"Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.","Is the triple ""Erythropoietin prevents Fatigue"" supported by the sentence: ""Epoetin treatment has been shown to induce lasting improvements in patients' sense of well-being, reduce fatigue, increase appetite and work capacity, and improve exercise tolerance, libido and work performance.""?",False, +7236347,Erythropoietin prevents anemia,2606,"Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.","Is the triple ""Erythropoietin prevents anemia"" supported by the sentence: ""Rates of hospitalisation for all causes, especially those associated with anaemia, may be reduced by epoetin treatment.""?",False, +18610239,Erythropoietin exacerbates injury,2607,"However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.","Is the triple ""Erythropoietin exacerbates injury"" supported by the sentence: ""However, EPO concentrations in critically ill patients complicated with AKI have not been evaluated sufficiently.""?",False, +14126866,Erythropoietin exacerbates anemia,2608,"Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.","Is the triple ""Erythropoietin exacerbates anemia"" supported by the sentence: ""Due to severe hemolysis, red blood cell (RBC) transfusions are often necessary, and anemia is aggravated by low erythropoietin (EPO) levels caused by acute renal failure.""?",False, +25818939,Erythropoietin predisposes neoplasm,2609,"Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.","Is the triple ""Erythropoietin predisposes neoplasm"" supported by the sentence: ""Increasing the sensitivity of the assay of erythropoietin in the exhypoxic mouse, a functional assay, or in an immunologic assay of specific protein concentration might aid in the early detection of yet another hormone marker of neoplasia.""?",False, +19869298,Erythropoietin predisposes coronary artery disorder,2610,CONCLUSION: Increased EPO and RDW might be risk factors for CAD.,"Is the triple ""Erythropoietin predisposes coronary artery disorder"" supported by the sentence: ""CONCLUSION: Increased EPO and RDW might be risk factors for CAD.""?",False, +19564296,Erythropoietin predisposes Asphyxia,2611,Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.,"Is the triple ""Erythropoietin predisposes Asphyxia"" supported by the sentence: ""Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth.""?",False, +19270398,Erythropoietin predisposes brain injury,2612,"According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.","Is the triple ""Erythropoietin predisposes brain injury"" supported by the sentence: ""According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.""?",False, +18282528,Erythropoietin predisposes chronic kidney disease,2613,"Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.","Is the triple ""Erythropoietin predisposes chronic kidney disease"" supported by the sentence: ""Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD.""?",False, +16056103,Erythropoietin predisposes Ischemic stroke,2614,CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.,"Is the triple ""Erythropoietin predisposes Ischemic stroke"" supported by the sentence: ""CONCLUSION: EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.""?",False, +14483144,Erythropoietin predisposes injury,2615,"METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.","Is the triple ""Erythropoietin predisposes injury"" supported by the sentence: ""METHODS: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-beta-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM.""?",False, +12166360,Erythropoietin predisposes kidney failure,2616,Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.,"Is the triple ""Erythropoietin predisposes kidney failure"" supported by the sentence: ""Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life.""?",False, +8361116,Erythropoietin predisposes anemia,2617,"Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.","Is the triple ""Erythropoietin predisposes anemia"" supported by the sentence: ""Cisplatin and carboplatin nephrotoxicity might lower erythropoietin (Epo) secretion and, by this mechanism, contribute to the anaemia that follows therapy with this chemotherapeutic agent.""?",False, +24327196,Daprodustat affects anemia,2618,METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.,"Is the triple ""Daprodustat affects anemia"" supported by the sentence: ""METHODS: This post hoc analysis evaluated pooled safety data for daprodustat from 3 phase 3 Japanese studies in dialysis-dependent and nondialysis patients with anemia of CKD.""?",False, +24574810,Daprodustat prevents anemia,2619,Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.,"Is the triple ""Daprodustat prevents anemia"" supported by the sentence: ""Daprodustat prevents Cyclosporine-A mediated anemia and peritubular capillary loss.""?",False, +19595886,mecobalamin related to vitamin B12 deficiency,2620,Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?,"Is the triple ""mecobalamin related to vitamin B12 deficiency"" supported by the sentence: ""Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?""?",False, +13417310,mecobalamin related to amyotrophic lateral sclerosis,2621,[Clinical trials of ultra-high-dose methylcobalamin in ALS].,"Is the triple ""mecobalamin related to amyotrophic lateral sclerosis"" supported by the sentence: ""[Clinical trials of ultra-high-dose methylcobalamin in ALS].""?",False, +26391120,vitamin B12 related to myocardial infarction,2622,[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].,"Is the triple ""vitamin B12 related to myocardial infarction"" supported by the sentence: ""[Effect of vitamin B 12 on the blood serum enzyme activity in experimental myocardial infarct].""?",False, +21860699,vitamin B12 related to type 2 diabetes mellitus,2623,"Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.","Is the triple ""vitamin B12 related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.""?",False, +20662929,vitamin B12 related to non-small cell lung carcinoma,2624,CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.,"Is the triple ""vitamin B12 related to non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSION: Same-day vitamin B12 and pemetrexed administration is a safe practice in NSCLC and malignant pleural mesothelioma patients.""?",False, +19346996,vitamin B12 related to myocardial ischemia,2625,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""vitamin B12 related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, +12974621,vitamin B12 related to osteoporosis,2626,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""vitamin B12 related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, +10934739,vitamin B12 related to chronic kidney disease,2627,Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.,"Is the triple ""vitamin B12 related to chronic kidney disease"" supported by the sentence: ""Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease.""?",False, +10883089,vitamin B12 related to depressive disorder,2628,BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.,"Is the triple ""vitamin B12 related to depressive disorder"" supported by the sentence: ""BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.""?",False, +10658870,vitamin B12 related to psoriasis,2629,Is vitamin B12 of value in psoriasis?,"Is the triple ""vitamin B12 related to psoriasis"" supported by the sentence: ""Is vitamin B12 of value in psoriasis?""?",False, +10535786,vitamin B12 related to atherosclerosis,2630,Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.,"Is the triple ""vitamin B12 related to atherosclerosis"" supported by the sentence: ""Therapeutic effect of ascorbic acid and vitamin B12 in cholesterol atherosclerosis.""?",False, +10535188,vitamin B12 related to lymphoma,2631,Serum vitamin B12 in leukemias and malignant lymphomas.,"Is the triple ""vitamin B12 related to lymphoma"" supported by the sentence: ""Serum vitamin B12 in leukemias and malignant lymphomas.""?",False, +10508686,vitamin B12 related to vitamin B12 deficiency,2632,[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].,"Is the triple ""vitamin B12 related to vitamin B12 deficiency"" supported by the sentence: ""[Clinical significance of determination of vitamin B12 in the blood in malignant anemia and in vitamin B12 deficiency].""?",False, +10438501,vitamin B12 related to iron deficiency anemia,2633,Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.,"Is the triple ""vitamin B12 related to iron deficiency anemia"" supported by the sentence: ""Combined vitamin B12 and folic acid therapy in iron deficiency anaemias.""?",False, +9977774,vitamin B12 related to psychotic disorder,2634,Letter: Vitamin B12 in late-onset psychosis of childhood.,"Is the triple ""vitamin B12 related to psychotic disorder"" supported by the sentence: ""Letter: Vitamin B12 in late-onset psychosis of childhood.""?",False, +9644935,vitamin B12 related to anemia,2635,"However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.","Is the triple ""vitamin B12 related to anemia"" supported by the sentence: ""However, anemia associated with vitamin B(12) deficiency was seldom macrocytic.""?",False, +9118739,vitamin B12 related to Low back pain,2636,"Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.","Is the triple ""vitamin B12 related to Low back pain"" supported by the sentence: ""Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.""?",False, +8678107,vitamin B12 related to Alzheimer disease,2637,"Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.","Is the triple ""vitamin B12 related to Alzheimer disease"" supported by the sentence: ""Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease.""?",False, +27330642,vitamin B12 causes depressive disorder,2638,"Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.","Is the triple ""vitamin B12 causes depressive disorder"" supported by the sentence: ""Treatment with folic acid and vitamin B12 led to 5-fold depression of plasma homocysteine in the proband, and complete normalization in the other treated member of the family.""?",False, +26003936,vitamin B12 causes diabetic neuropathy,2639,Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?,"Is the triple ""vitamin B12 causes diabetic neuropathy"" supported by the sentence: ""Can faulty vitamin B-12 (cobalamin) metabolism produce diabetic neuropathy?""?",False, +17687811,vitamin B12 causes osteoporosis,2640,"In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.","Is the triple ""vitamin B12 causes osteoporosis"" supported by the sentence: ""In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model results in severe postweaning growth retardation and osteoporosis, and the severity and time of onset of this phenotype in the offspring depends on the maternal genotype.""?",False, +11993792,vitamin B12 causes Reduced blood folate concentration,2641,RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.,"Is the triple ""vitamin B12 causes Reduced blood folate concentration"" supported by the sentence: ""RESULTS: Derangement of DNA synthesis occurred due to an impaired de novo pathway of thymidylate synthesis in both vitamin-B12- and folate-deficient human megaloblastic bone marrows as well as in the bone marrows of rhesus monkeys and rats with experimentally induced folate deficiency.""?",False, +10806959,vitamin B12 causes psychotic disorder,2642,"Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.","Is the triple ""vitamin B12 causes psychotic disorder"" supported by the sentence: ""Cyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia.""?",False, +10716413,vitamin B12 causes vitamin B12 deficiency,2643,[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].,"Is the triple ""vitamin B12 causes vitamin B12 deficiency"" supported by the sentence: ""[DISTURBANCE IN FOLIC ACID METABOLISM IN VITAMIN B12 DEFICIENCY INDUCED BY ANTI-VITAMIN B12].""?",False, +9828196,vitamin B12 causes anemia,2644,Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.,"Is the triple ""vitamin B12 causes anemia"" supported by the sentence: ""Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B(12) deficiencies.""?",False, +7900732,vitamin B12 causes atherosclerosis,2645,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""vitamin B12 causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, +25091008,vitamin B12 affects HIV infectious disease,2646,"Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.","Is the triple ""vitamin B12 affects HIV infectious disease"" supported by the sentence: ""Hence, vitamin B 12 is a beneficial immunological modulator of HIV infection and can be a potent game changer in resource constrained set up.""?",False, +20098295,vitamin B12 affects depressive disorder,2647,"At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.""?",False, +19763864,vitamin B12 affects Alzheimer disease,2648,"This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.","Is the triple ""vitamin B12 affects Alzheimer disease"" supported by the sentence: ""This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults.""?",False, +18490813,vitamin B12 affects depressive disorder,2649,"In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""In the multivariable analysis, an increase in depression risk was observed amongst participants nutritionally at risk OR = 3.47 (1.05-11.46), whereas having low levels of folic acid and Vitamins B12 were not associated with depression risk.""?",False, +17348852,vitamin B12 affects vitamin B12 deficiency,2650,"Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.","Is the triple ""vitamin B12 affects vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 deficiency resulted in higher homocysteine and insulin levels, which were normalised by supplementation with either vitamin B12 or n-3 PUFA.""?",False, +16930257,vitamin B12 affects amyotrophic lateral sclerosis,2651,"Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.","Is the triple ""vitamin B12 affects amyotrophic lateral sclerosis"" supported by the sentence: ""Folate, Vitamin B12 (VitB12) and Vitamin B6 (VitB6) are important elements involved in the Hcy metabolism and we proposed that medications which could promote the absorption of folate, VitB12 and VitB6 might have benefit for ALS.""?",False, +13607058,vitamin B12 affects depressive disorder,2652,"Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.","Is the triple ""vitamin B12 affects depressive disorder"" supported by the sentence: ""Although a variety of symptoms are described, there are only sparse data on the role of vitamin B12 in depression.""?",False, +12773836,vitamin B12 affects atherosclerosis,2653,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""vitamin B12 affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, +11945900,vitamin B12 affects Pregnancy,2654,"RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""RESULTS: Compared to untreated animals, serum and liver Vitamin B12 concentrations of the treated ewes were increased at least 70% during gestation.""?",False, +11927611,vitamin B12 affects diabetic neuropathy,2655,"However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.","Is the triple ""vitamin B12 affects diabetic neuropathy"" supported by the sentence: ""However, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy.""?",False, +10798681,vitamin B12 affects type 2 diabetes mellitus,2656,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""vitamin B12 affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, +10424959,vitamin B12 affects anemia,2657,[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].,"Is the triple ""vitamin B12 affects anemia"" supported by the sentence: ""[Capacity of potentiation the effect of vitamin B12 per os in experimental anemia due to phenylhydrazine hydrochloride in mouse by a part of mucoprotein fractions obtained from the hog gastric mucosa].""?",False, +8733280,vitamin B12 affects Pregnancy,2658,"The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.","Is the triple ""vitamin B12 affects Pregnancy"" supported by the sentence: ""The concentrations of retinol, thiamin, pyridoxal 5'-phosphate serum folate and vitamin B12 decreased during pregnancy.""?",False, +8015838,vitamin B12 affects chronic kidney disease,2659,Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.,"Is the triple ""vitamin B12 affects chronic kidney disease"" supported by the sentence: ""Careful prospective studies of the homocysteine-lowering effect of high-dose parenteral vitamin B12 in ESRD should be undertaken.""?",False, +23636866,vitamin B12 produces vitamin B12 deficiency,2660,"Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.","Is the triple ""vitamin B12 produces vitamin B12 deficiency"" supported by the sentence: ""Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein.""?",False, +11124683,vitamin B12 disrupts chronic kidney disease,2661,"CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.","Is the triple ""vitamin B12 disrupts chronic kidney disease"" supported by the sentence: ""CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.""?",False, +20603701,vitamin B12 prevents Alzheimer disease,2662,"Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.","Is the triple ""vitamin B12 prevents Alzheimer disease"" supported by the sentence: ""Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-beta (Abeta) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus.""?",False, +14586818,vitamin B12 prevents anemia,2663,"The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.","Is the triple ""vitamin B12 prevents anemia"" supported by the sentence: ""The addition of folate and especially vitamin B-12 with formula feedings, provided an effective and nontoxic means of reducing anemia of prematurity.""?",False, +10782972,vitamin B12 prevents atherosclerosis,2664,"Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.","Is the triple ""vitamin B12 prevents atherosclerosis"" supported by the sentence: ""Randomized trials are in progress investigating whether multivitamin therapy with folic acid, vitamin B12, and vitamin B6 to reduce plasma homocysteine levels will reduce the risk for atherosclerotic vascular disease.""?",False, +9545669,vitamin B12 prevents vitamin B12 deficiency,2665,Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.,"Is the triple ""vitamin B12 prevents vitamin B12 deficiency"" supported by the sentence: ""Vitamin B12 or methionine deficiency had no effect on the methylation reaction or on bone marrow folate levels although the vitamin B12 content in bone marrow was reduced in vitamin B12 deficiency.""?",False, +27415421,vitamin B12 predisposes myocardial infarction,2666,"BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).","Is the triple ""vitamin B12 predisposes myocardial infarction"" supported by the sentence: ""BACKGROUND: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR).""?",False, +21063265,vitamin B12 predisposes depressive disorder,2667,Risk of depression in pregnant women with low-normal serum Vitamin B12.,"Is the triple ""vitamin B12 predisposes depressive disorder"" supported by the sentence: ""Risk of depression in pregnant women with low-normal serum Vitamin B12.""?",False, +20875915,vitamin B12 predisposes chronic kidney disease,2668,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""vitamin B12 predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, +15081186,vitamin B12 predisposes osteoporosis,2669,BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.,"Is the triple ""vitamin B12 predisposes osteoporosis"" supported by the sentence: ""BACKGROUND: Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial.""?",False, +12678935,vitamin B12 predisposes atherosclerosis,2670,"Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.","Is the triple ""vitamin B12 predisposes atherosclerosis"" supported by the sentence: ""Because of the atherogenic effect of hyperhomocysteinemia, the treatment with folic acid and vitamin B12 should be accepted as an options to lower the risk factors for the rapid atherosclerosis in patients on dialysis, thus reducing the occurrence and fatality of cardiovascular diseases.""?",False, +12664527,vitamin B12 predisposes Alzheimer disease,2671,"OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.","Is the triple ""vitamin B12 predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.""?",False, +8590188,vitamin B12 predisposes anemia,2672,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""vitamin B12 predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, +22149451,Ipragliflozin affects type 2 diabetes mellitus,2673,"Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.","Is the triple ""Ipragliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Rationale and design of an investigator-initiated, multicenter, prospective open-label, randomized trial to evaluate the effect of ipragliflozin on endothelial dysfunction in type 2 diabetes and chronic kidney disease: the PROCEED trial.BACKGROUND: Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction.""?",False, +24120079,Ertugliflozin disrupts diabetes mellitus,2674,"Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.","Is the triple ""Ertugliflozin disrupts diabetes mellitus"" supported by the sentence: ""Therefore, the Ertugliflozin to Reduce Arrhythmic burden in ICD +/- CRT patientS (ERASe) trial was designed to investigate the efficacy and safety of ertugliflozin in patients with reduced and midrange ejection fraction (EF) with or without diabetes.""?",False, +23006843,Empagliflozin related to diabetes mellitus,2675,"We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.","Is the triple ""Empagliflozin related to diabetes mellitus"" supported by the sentence: ""We sought to investigate: (1) whether combination of empagliflozin and liraglutide has additive effect against diabetes-induced cytotoxicity, and (2) potential mechanisms involved in cardioprotective effect of empagliflozin and liraglutide in diabetes.""?",False, +22183651,Empagliflozin related to type 2 diabetes mellitus,2676,Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.,"Is the triple ""Empagliflozin related to type 2 diabetes mellitus"" supported by the sentence: ""Cost-effectiveness of empagliflozin compared with liraglutide based on cardiovascular outcome trials in Type II diabetes.""?",False, +24924157,Empagliflozin causes non-alcoholic fatty liver disease,2677,This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.,"Is the triple ""Empagliflozin causes non-alcoholic fatty liver disease"" supported by the sentence: ""This study investigated the functional implications of EMPA on the multifactorial pathogenesis of NAFLD and potential underlying molecular mechanisms of pathogenesis.""?",False, +23515975,Empagliflozin causes myocardial infarction,2678,"METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).","Is the triple ""Empagliflozin causes myocardial infarction"" supported by the sentence: ""METHODS: Fourteen non-diabetic rats underwent myocardial infarction induction, and treated or not (control)immediately after myocardial infarction by daily empagliflozin (30 mg/kg/day).""?",False, +23240834,Empagliflozin causes acute kidney failure,2679,Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.,"Is the triple ""Empagliflozin causes acute kidney failure"" supported by the sentence: ""Empagliflozin-induced severe osmotic nephrosis and acute renal injury in advanced chronic kidney disease.""?",False, +25094844,Empagliflozin affects diabetes mellitus,2680,Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.,"Is the triple ""Empagliflozin affects diabetes mellitus"" supported by the sentence: ""Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus.""?",False, +24520517,Empagliflozin affects Insulin resistance,2681,Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.,"Is the triple ""Empagliflozin affects Insulin resistance"" supported by the sentence: ""Renoprotective effect of empagliflozin in cafeteria diet-induced insulin resistance in rats: Modulation of HMGB-1/TLR-4/NF-kappaB axis.""?",False, +24184835,Empagliflozin affects diabetic kidney disease,2682,"Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.","Is the triple ""Empagliflozin affects diabetic kidney disease"" supported by the sentence: ""Despite its effects on diabetic nephropathy, empagliflozin did not activate the Sestrin2/AMP-activated protein kinase pathway in this study.""?",False, +24091231,Empagliflozin affects kidney disorder,2683,Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.,"Is the triple ""Empagliflozin affects kidney disorder"" supported by the sentence: ""Nephrotic-range proteinuria in type 2 diabetes: Effects of empagliflozin on kidney disease progression and clinical outcomes.""?",False, +22935616,Empagliflozin affects non-alcoholic fatty liver disease,2684,"Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.","Is the triple ""Empagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress, autophagy and apoptosis.""?",False, +22175650,Empagliflozin affects acute kidney failure,2685,We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.,"Is the triple ""Empagliflozin affects acute kidney failure"" supported by the sentence: ""We further demonstrate that the beneficial effects of empagliflozin are likely mediated via reducing LPS-induced acute renal injury.""?",False, +22027265,Empagliflozin affects type 2 diabetes mellitus,2686,Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.,"Is the triple ""Empagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""Our data possibly support a beneficial effect of empagliflozin in type 2 diabetes required for coronary revascularization therapy.""?",False, +21867589,Empagliflozin affects myocardial infarction,2687,Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.,"Is the triple ""Empagliflozin affects myocardial infarction"" supported by the sentence: ""Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA-REG OUTCOME trial.AIM: To investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS-HF DM ) with mortality using data from the EMPA-REG OUTCOME trial.""?",False, +21618629,Empagliflozin affects pulmonary arterial hypertension,2688,"While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.","Is the triple ""Empagliflozin affects pulmonary arterial hypertension"" supported by the sentence: ""While empagliflozin has been reported to lower systemic hypertension due to increased diuresis, the effect of empagliflozin on PAH is unknown.""?",False, +22842915,Empagliflozin disrupts type 2 diabetes mellitus,2689,"AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).","Is the triple ""Empagliflozin disrupts type 2 diabetes mellitus"" supported by the sentence: ""AIMS: The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of sodium-glucose co-transporter-2 inhibition in HF with preserved EF (HFpEF).""?",False, +23528682,Empagliflozin prevents myocardial infarction,2690,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Empagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, +23286446,Empagliflozin prevents acute kidney failure,2691,"In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.","Is the triple ""Empagliflozin prevents acute kidney failure"" supported by the sentence: ""In conclusion, empagliflozin can protect against subclinical acute kidney injury in diabetic albino Wistar rats after myocardial infarction induction, which could improve the clinical outcome of SGLT-2 inhibitors in diabetic patients.""?",False, +24551007,Empagliflozin predisposes acute kidney failure,2692,Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.,"Is the triple ""Empagliflozin predisposes acute kidney failure"" supported by the sentence: ""Empagliflozin reduces markers of acute kidney injury in patients with acute decompensated heart failure.""?",False, +24497752,Empagliflozin predisposes hypoglycemia,2693,We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.,"Is the triple ""Empagliflozin predisposes hypoglycemia"" supported by the sentence: ""We suggest a low starting dose of empagliflozin with careful titration due to the risk of hypoglycaemia.""?",False, +23163444,Empagliflozin predisposes diabetic kidney disease,2694,These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.,"Is the triple ""Empagliflozin predisposes diabetic kidney disease"" supported by the sentence: ""These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.""?",False, +21786786,Dapagliflozin related to Alzheimer disease,2695,"For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.","Is the triple ""Dapagliflozin related to Alzheimer disease"" supported by the sentence: ""For instance, anti-diabetic drugs, such as insulin, metformin, liraglutide, and dapagliflozin, and cardiovascular drugs, such as cilostazol, candesartan, telmisartan, prazosin, and dabigatran, could serendipitously provide previously unearthed benefits in AD.""?",False, +23582915,Dapagliflozin causes Weight loss,2696,"RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).","Is the triple ""Dapagliflozin causes Weight loss"" supported by the sentence: ""RESULTS: Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).""?",False, +25156234,Dapagliflozin affects non-alcoholic fatty liver disease,2697,The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.,"Is the triple ""Dapagliflozin affects non-alcoholic fatty liver disease"" supported by the sentence: ""The regulation of AMPK/NLRP3 signaling pathway affected the effects of dapagliflozin on nonalcoholic fatty liver.""?",False, +23530734,Dapagliflozin affects Albuminuria,2698,The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.,"Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58.""?",False, +23107287,Dapagliflozin affects type 1 diabetes mellitus,2699,"In conclusion, dapagliflozin had a significant effect on type 1 diabetes.","Is the triple ""Dapagliflozin affects type 1 diabetes mellitus"" supported by the sentence: ""In conclusion, dapagliflozin had a significant effect on type 1 diabetes.""?",False, +23072376,Dapagliflozin affects ischemia reperfusion injury,2700,"RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.","Is the triple ""Dapagliflozin affects ischemia reperfusion injury"" supported by the sentence: ""RESULTS: In the present study, we sought to investigate the effects of DAPA on the cardiac ischemia/reperfusion (I/R) injury.""?",False, +22916804,Dapagliflozin affects diabetic kidney disease,2701,Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.,"Is the triple ""Dapagliflozin affects diabetic kidney disease"" supported by the sentence: ""Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.""?",False, +22845588,Dapagliflozin affects type 2 diabetes mellitus,2702,This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.,"Is the triple ""Dapagliflozin affects type 2 diabetes mellitus"" supported by the sentence: ""This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.""?",False, +22578057,Dapagliflozin affects Albuminuria,2703,"The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).","Is the triple ""Dapagliflozin affects Albuminuria"" supported by the sentence: ""The renoprotection provided by SGLT2i was further confirmed in the CREDENCE study, which showed a 30% reduction in progression of chronic kidney disease, and in the DELIGHT study, which demonstrated a reduction in albuminuria with dapagliflozin compared with placebo (- 21.0%, confidence interval [CI] - 34.1 to - 5.2, p = 0.011).""?",False, +22163310,Dapagliflozin affects Weight loss,2704,The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.,"Is the triple ""Dapagliflozin affects Weight loss"" supported by the sentence: ""The secondary objectives included assessing the effects of dapagliflozin on weight reduction and blood pressure control and to determining its safety.""?",False, +21622453,Dapagliflozin affects atrial fibrillation,2705,Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.,"Is the triple ""Dapagliflozin affects atrial fibrillation"" supported by the sentence: ""Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.""?",False, +25362847,Dapagliflozin disrupts acute kidney failure,2706,"Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).","Is the triple ""Dapagliflozin disrupts acute kidney failure"" supported by the sentence: ""Compared with placebo, dapagliflozin was associated with a significant reduction in acute kidney injury (OR: 0.71, 95% CI: 0.60 to 0.83), and increased the risk of genital infection (OR: 8.21, 95% CI: 4.19 to 16.12).""?",False, +23258105,Dapagliflozin disrupts kidney failure,2707,"In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.","Is the triple ""Dapagliflozin disrupts kidney failure"" supported by the sentence: ""In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy.""?",False, +22845589,Dapagliflozin disrupts diabetes mellitus,2708,"Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).","Is the triple ""Dapagliflozin disrupts diabetes mellitus"" supported by the sentence: ""Dapagliflozin led to a 32% reduction in diabetes incidence (hazard ratio 0.68, 95% CI 0.50-0.94; P = 0.019).""?",False, +23973238,Dapagliflozin prevents type 2 diabetes mellitus,2709,INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .,"Is the triple ""Dapagliflozin prevents type 2 diabetes mellitus"" supported by the sentence: ""INTERPRETATION: Treatment with dapagliflozin reduced the incidence of new-onset type 2 diabetes in participants with chronic kidney disease and HF without a reduction in HbA 1c .""?",False, +23528684,Dapagliflozin prevents myocardial infarction,2710,"CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.","Is the triple ""Dapagliflozin prevents myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin versus placebo reduce HHF but none reduces MI and stroke.""?",False, +23138841,Dapagliflozin prevents diabetic kidney disease,2711,"Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.","Is the triple ""Dapagliflozin prevents diabetic kidney disease"" supported by the sentence: ""Moreover, Dap protects against diabetic kidney disease by inhibiting SGK1 and reversing the T cell imbalance.""?",False, +22845590,Dapagliflozin prevents diabetes mellitus,2712,"CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.","Is the triple ""Dapagliflozin prevents diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: In this exploratory analysis among patients with HFrEF, treatment with dapagliflozin reduced the incidence of new diabetes.""?",False, +22832530,Dapagliflozin prevents kidney failure,2713,BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.,"Is the triple ""Dapagliflozin prevents kidney failure"" supported by the sentence: ""BACKGROUND: Dapagliflozin reduces the risk of kidney failure and heart failure in patients with chronic kidney disease.""?",False, +21513723,Dapagliflozin prevents obesity disorder,2714,"We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.","Is the triple ""Dapagliflozin prevents obesity disorder"" supported by the sentence: ""We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration.""?",False, +25236689,Dapagliflozin predisposes kidney failure,2715,"CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.","Is the triple ""Dapagliflozin predisposes kidney failure"" supported by the sentence: ""CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.""?",False, +23072379,Dapagliflozin predisposes myocardial infarction,2716,"Also, the administration of DAPA mitigated the production of myocardial infarction markers.","Is the triple ""Dapagliflozin predisposes myocardial infarction"" supported by the sentence: ""Also, the administration of DAPA mitigated the production of myocardial infarction markers.""?",False, +20833370,Methyldopa related to type 1 diabetes mellitus,2717,"SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.","Is the triple ""Methyldopa related to type 1 diabetes mellitus"" supported by the sentence: ""SUMMARY: Methyldopa blocks the diabetes-specific function of HLA-DQ8, which represents a personalized medicine approach to treat the underlying autoimmunity in T1D.""?",False, +15433400,Methyldopa related to preeclampsia,2718,"Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.","Is the triple ""Methyldopa related to preeclampsia"" supported by the sentence: ""Previous preeclampsia (OR=3.28), primiparity (OR=2.35), methyldopa (OR=3.76), number of check-ups (OR=2.3), positive family history (OR=1.4) and in vitro fertilisation (OR=1.15) were found as risk factors associated with the occurrence of preeclampsia and preeclampsia superimposed on preexisting hypertension.""?",False, +7364754,Methyldopa related to hypertensive disorder,2719,"[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].","Is the triple ""Methyldopa related to hypertensive disorder"" supported by the sentence: ""[Effect of reserpine, octadine and methyldopa on the distribution of cardiac output in hypertension].""?",False, +25805913,Methyldopa causes hypertensive disorder,2720,Letter: Methyldopa-induced hypertension.,"Is the triple ""Methyldopa causes hypertensive disorder"" supported by the sentence: ""Letter: Methyldopa-induced hypertension.""?",False, +23430063,Methyldopa causes preeclampsia,2721,"The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.","Is the triple ""Methyldopa causes preeclampsia"" supported by the sentence: ""The effects of co-exposure to atrasentan (ETA receptor blocker, 10 mg/kg/day) or terutroban (TXA2 receptor blocker, 10 mg/kg/day) on cardiovascular and renal anomalies induced by PE were assessed on gestational day 20 (GD20) and at weaning time and compared with those evoked by the sympatholytic drug alpha-methyldopa (alpha-MD, 100 mg/kg/day), a prototypic therapy for PE management.""?",False, +26257846,Methyldopa affects hypertensive disorder,2722,"In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.","Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""In a two-year study of 547 hypertensive patients receiving diuretics, the addition of guanadrel sulfate or methyldopa reduced elevated blood pressure to a similar degree and provided good control in 70% of the patients.""?",False, +10671192,Methyldopa affects hypertensive disorder,2723,A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.,"Is the triple ""Methyldopa affects hypertensive disorder"" supported by the sentence: ""A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.""?",False, +26170425,Methyldopa prevents hypertensive disorder,2724,Methyldopa decreased the supine hypertension and increased the standing blood pressure.,"Is the triple ""Methyldopa prevents hypertensive disorder"" supported by the sentence: ""Methyldopa decreased the supine hypertension and increased the standing blood pressure.""?",False, +8219214,Methyldopa exacerbates hypertensive disorder,2725,Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.,"Is the triple ""Methyldopa exacerbates hypertensive disorder"" supported by the sentence: ""Comparison of magnesium and methyldopa for the control of blood pressure in pregnancies complicated with hypertension.""?",False, +20611289,Methyldopa predisposes preeclampsia,2726,"There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.","Is the triple ""Methyldopa predisposes preeclampsia"" supported by the sentence: ""There is no evidence of a difference in the risk of severe pre-eclampsia, changed/stopped drug due to maternal side-effects, elective delivery, admission to neonatal or intensive care nursery when other antihypertensive drugs are compared with methyldopa, calcium channel blockers or beta blockers.""?",False, +19343164,Exemestane related to male breast carcinoma,2727,Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.,"Is the triple ""Exemestane related to male breast carcinoma"" supported by the sentence: ""Everolimus and exemestane in long survival hormone receptor positive male breast cancer: case report.""?",False, +14849934,Exemestane related to ductal breast carcinoma in situ,2728,CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.,"Is the triple ""Exemestane related to ductal breast carcinoma in situ"" supported by the sentence: ""CONCLUSIONS: Exemestane reduces proliferation in ER-positive DCIS.""?",False, +14694867,Exemestane related to non-small cell lung carcinoma,2729,Further studies are needed to assess the activity of exemestane in NSCLC.,"Is the triple ""Exemestane related to non-small cell lung carcinoma"" supported by the sentence: ""Further studies are needed to assess the activity of exemestane in NSCLC.""?",False, +11511167,Exemestane related to neoplasm,2730,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Exemestane related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, +18732584,Exemestane affects neoplasm,2731,"RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).","Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""RESULTS: High IGF1R tumor expression was significantly associated with exemestane therapy for RFS (Hazard Ratio (HR) 0.74, 95% Confidence Interval (CI) 0.58-0.95, p = 0.02).""?",False, +14063167,Exemestane affects neoplasm,2732,Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.,"Is the triple ""Exemestane affects neoplasm"" supported by the sentence: ""Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control animals.""?",False, +16053578,Exemestane prevents breast neoplasm,2733,"However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.","Is the triple ""Exemestane prevents breast neoplasm"" supported by the sentence: ""However, currently in the Dutch population, 140 women would need to use exemestane for three years in order to prevent one invasive breast tumour.""?",False, +20235097,Rivizor disrupts neoplasm,2734,Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.,"Is the triple ""Rivizor disrupts neoplasm"" supported by the sentence: ""Combining weekly MK2206 with the aromatase inhibitor vorozole (0.12 mg/kg BW/day) showed that each compound alone reduced tumor multiplicity 40-50%.""?",False, +24226617,Letrozole related to polycystic ovary syndrome,2735,"Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.","Is the triple ""Letrozole related to polycystic ovary syndrome"" supported by the sentence: ""Also, evidence suggesting the use of vitamin D, statins, and Letrozole as emerging therapies in PCOS have been summarized in this review.""?",False, +19925368,Letrozole related to infertility disorder,2736,"OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.","Is the triple ""Letrozole related to infertility disorder"" supported by the sentence: ""OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.""?",False, +13004646,Letrozole related to endometriosis,2737,Letrozole and norethisterone acetate in rectovaginal endometriosis.,"Is the triple ""Letrozole related to endometriosis"" supported by the sentence: ""Letrozole and norethisterone acetate in rectovaginal endometriosis.""?",False, +11511165,Letrozole related to neoplasm,2738,"In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.","Is the triple ""Letrozole related to neoplasm"" supported by the sentence: ""In postmenopausal women, anastrozole, letrozole and exemestane appear to have superior efficacy and an improved toxicity profile than tamoxifen, and fulvestrant seems to be at least as effective as anastrozole in patients in whom tumors have progressed after prior endocrine treatment.""?",False, +22485512,Letrozole causes infertility disorder,2739,(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.,"Is the triple ""Letrozole causes infertility disorder"" supported by the sentence: ""(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.BACKGROUND: Myrianthus arboreus P.""?",False, +17708157,Letrozole causes neoplasm,2740,RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.,"Is the triple ""Letrozole causes neoplasm"" supported by the sentence: ""RESULTS: We find pervasive differential coexpression between the untreated and letrozole-treated tumor samples as evidence of letrozole-induced tumor adaptation.""?",False, +14659251,Letrozole causes endometriosis,2741,"INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.","Is the triple ""Letrozole causes endometriosis"" supported by the sentence: ""INTERVENTION(S): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy.""?",False, +11078418,Letrozole causes polycystic ovary syndrome,2742,Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.,"Is the triple ""Letrozole causes polycystic ovary syndrome"" supported by the sentence: ""Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.""?",False, +10282160,Letrozole causes hypogonadism,2743,"In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.","Is the triple ""Letrozole causes hypogonadism"" supported by the sentence: ""In addition, deprivation of endogenous estrogens, by blocking their formation using the aromatase inhibitor letrozole, induced OT hypo-responsiveness comparable to that observed in hypo rabbits.""?",False, +25205942,Letrozole affects ovarian hyperstimulation syndrome,2744,Whether letrozole has a direct effect in reducing OHSS requires further investigation.,"Is the triple ""Letrozole affects ovarian hyperstimulation syndrome"" supported by the sentence: ""Whether letrozole has a direct effect in reducing OHSS requires further investigation.""?",False, +18870552,Letrozole affects Pregnancy,2745,CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.,"Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""CONCLUSION: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.""?",False, +18835925,Letrozole affects inflammatory breast carcinoma,2746,"The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.","Is the triple ""Letrozole affects inflammatory breast carcinoma"" supported by the sentence: ""The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non-IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC-366 and SUM-149 cell lines.""?",False, +10866444,Letrozole affects Pregnancy,2747,"In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.","Is the triple ""Letrozole affects Pregnancy"" supported by the sentence: ""In the present study, we have examined the effect of prior low dose letrozole treatment on pregnancy and lactation.""?",False, +7871182,Letrozole affects neoplasm,2748,"The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.","Is the triple ""Letrozole affects neoplasm"" supported by the sentence: ""The antitumor effect of letrozole was substantial, making it difficult to detect any additional effect on the tumors when letrozole was combined with the antiestrogens.""?",False, +21352213,Letrozole disrupts Pregnancy,2749,"Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).","Is the triple ""Letrozole disrupts Pregnancy"" supported by the sentence: ""Compared with CC, letrozole improved live birth rates (3 RCTs, 1043 women, risk ratio [RR] 1.43, 95% confidence interval [CI] 1.17-1.75, moderate-certainty evidence) and clinical pregnancy rates (6 RCTs, 1284 women, RR 1.45, 95% CI 1.23-1.70, moderate-certainty evidence) and reduced time-to-pregnancy (6 RCTs, 1235 women, hazard ratio [HR] 1.72, 95% CI 1.38-2.15, moderate-certainty evidence).""?",False, +25448977,Letrozole prevents prostate cancer,2750,To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.,"Is the triple ""Letrozole prevents prostate cancer"" supported by the sentence: ""To test whether the formation of E2 from T by aromatase could lead to estrogen genotoxicity and prostate carcinogenesis we then rats treated with T and 2F-E2 also with letrozole and found that it reduced prostate cancer incidence by about 50%.""?",False, +19305611,Letrozole prevents Spontaneous abortion,2751,SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.,"Is the triple ""Letrozole prevents Spontaneous abortion"" supported by the sentence: ""SUMMARY ANSWER: Letrozole significantly decreases the risk of miscarriage and does not increase the risk of major congenital anomalies or adverse pregnancy or neonatal outcomes compared with natural cycles in patients undergoing ART.""?",False, +17892609,Letrozole prevents ovarian hyperstimulation syndrome,2752,"Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.","Is the triple ""Letrozole prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.""?",False, +13373696,Letrozole prevents neoplasm,2753,"Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).","Is the triple ""Letrozole prevents neoplasm"" supported by the sentence: ""Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P=0.0009).""?",False, +20363763,Letrozole predisposes ovarian hyperstimulation syndrome,2754,Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.,"Is the triple ""Letrozole predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""Further investigation is required to determine if patients treated with letrozole during the IVF stimulation protocol are at increased risk for developing OHSS as a result of these findings.""?",False, +19305612,Letrozole predisposes Spontaneous abortion,2755,"MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).","Is the triple ""Letrozole predisposes Spontaneous abortion"" supported by the sentence: ""MAIN RESULTS AND THE ROLE OF CHANCE: The risk of miscarriage was significantly lower in women administered letrozole (adjusted OR [aOR], 0.37, 95% CI, 0.30-0.47, P < 0.001).""?",False, +26765214,Formestane affects neoplasm,2756,"In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.","Is the triple ""Formestane affects neoplasm"" supported by the sentence: ""In contrast, neither dose of 4-hydroxyandrostenedione had any effect on tumor incidence and only the higher dose slightly decreased tumor multiplicity.""?",False, +25526748,Formestane disrupts neoplasm,2757,Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.,"Is the triple ""Formestane disrupts neoplasm"" supported by the sentence: ""Background: Treatment of ER + breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks.""?",False, +13022860,Formestane prevents neoplasm,2758,"Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.","Is the triple ""Formestane prevents neoplasm"" supported by the sentence: ""Compared to a tumor area of 1400 mm2 after 21 days of unopposed tumor growth, formestane treatment, irrespective of concomitant black cohosh application, significantly reduced neoplastic growth by 50%.""?",False, +26325498,Aminoglutethimide affects neoplasm,2759,The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.,"Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""The combined effects of estrogen deprivation associated with androgen preservation might be significant in the therapeutic action of AG in hormone-responsive neoplasms.""?",False, +12185634,Aminoglutethimide affects neoplasm,2760,"Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.","Is the triple ""Aminoglutethimide affects neoplasm"" supported by the sentence: ""Moreover, we have recently found that an HPMA conjugate containing a combination of both Dox and the aromatase inhibitor aminoglutethimide (AGM) shows significantly increased anti-tumour activity in vitro.""?",False, +22275813,Relugolix related to prostate cancer,2761,Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.,"Is the triple ""Relugolix related to prostate cancer"" supported by the sentence: ""Phase 3 HERO Trial Finds Relugolix to Be Superior to Leuprolide in Prostate Cancer.""?",False, +23469407,Relugolix prevents Pain,2762,CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.,"Is the triple ""Relugolix prevents Pain"" supported by the sentence: ""CONCLUSIONS: Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis.""?",False, +25422975,Abiraterone related to castration-resistant prostate carcinoma,2763,CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.,"Is the triple ""Abiraterone related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSIONS: This study demonstrates that the efficacy of first-line abiraterone and prednisone in docetaxel-naive mCRPC do not vary significantly based on the receipt of prior prostate-directed LT.""?",False, +20717678,Abiraterone related to prostate cancer,2764,Abiraterone and spironolactone in prostate cancer: a combination to avoid.,"Is the triple ""Abiraterone related to prostate cancer"" supported by the sentence: ""Abiraterone and spironolactone in prostate cancer: a combination to avoid.""?",False, +16721978,Abiraterone affects prostate cancer,2765,The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.,"Is the triple ""Abiraterone affects prostate cancer"" supported by the sentence: ""The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer.""?",False, +15794241,Abiraterone prevents neoplasm,2766,"The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.","Is the triple ""Abiraterone prevents neoplasm"" supported by the sentence: ""The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established.""?",False, +19010753,Abiraterone predisposes prostate cancer,2767,"The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.","Is the triple ""Abiraterone predisposes prostate cancer"" supported by the sentence: ""The initial 5alpha-reduced metabolite, 3-keto-5alpha-abiraterone, is present at higher concentrations than D4A in patients with prostate cancer taking abiraterone, and is an androgen receptor agonist, which promotes prostate cancer progression.""?",False, +11344546,Finasteride related to acne,2768,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to acne"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, +11344545,Finasteride related to alopecia,2769,5 alpha-reductase and finasteride in pattern alopecia and acne.,"Is the triple ""Finasteride related to alopecia"" supported by the sentence: ""5 alpha-reductase and finasteride in pattern alopecia and acne.""?",False, +9840638,Finasteride related to prostate cancer,2770,CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.,"Is the triple ""Finasteride related to prostate cancer"" supported by the sentence: ""CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer.""?",False, +7359591,Finasteride related to benign prostatic hyperplasia,2771,"CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).","Is the triple ""Finasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: Despite modest improvements in maximum urinary flow rates and symptom scores, finasteride is a first-line treatment option in those with moderate uncomplicated BPH, especially in patients with a large prostate (> or = 40 ml).""?",False, +21759063,Finasteride causes benign prostatic hyperplasia,2772,"Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.","Is the triple ""Finasteride causes benign prostatic hyperplasia"" supported by the sentence: ""Twenty dogs were divided into 4 groups (n = 5): BPH + finasteride group, dogs which were induced for BPH and received oral finasteride once daily for 1 month; BPH group, dogs which were induced for BPH and received placebo; finasteride group, normal dogs which received finasteride; and normal group, normal intact dogs which did not receive treatment.""?",False, +11694493,Finasteride causes prostate cancer,2773,"The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).","Is the triple ""Finasteride causes prostate cancer"" supported by the sentence: ""The results indicated that the period prevalence of prostate cancer was reduced by 24.8% due to finasteride, whereas an increase in the rate of high-grade tumors (Gleason score 8-10) among men who were diagnosed with cancer also was found (5.0% in the PCPT placebo arm vs. 11.9% in the PCPT finasteride arm).""?",False, +11326933,Finasteride affects prostate cancer,2774,The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.,"Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""The results of the Prostate Cancer Prevention Trial spurred debate because finasteride was found to reduce the period prevalence of prostate cancer by about 25% while also increasing the rate of high-grade prostate cancers.""?",False, +9873046,Finasteride affects benign prostatic hyperplasia,2775,Indeed the effect of finasteride in BPH was proven in clinical studies.,"Is the triple ""Finasteride affects benign prostatic hyperplasia"" supported by the sentence: ""Indeed the effect of finasteride in BPH was proven in clinical studies.""?",False, +9845785,Finasteride affects alopecia,2776,We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.,"Is the triple ""Finasteride affects alopecia"" supported by the sentence: ""We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia.""?",False, +7857572,Finasteride affects prostate cancer,2777,"To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.","Is the triple ""Finasteride affects prostate cancer"" supported by the sentence: ""To gain insight to the molecular effects of finasteride on prostate cancer development, we studied six prostate cancers diagnosed during finasteride treatment for benign prostatic hyperplasia.""?",False, +21155186,Finasteride disrupts benign prostatic hyperplasia,2778,"Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.","Is the triple ""Finasteride disrupts benign prostatic hyperplasia"" supported by the sentence: ""Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP.""?",False, +10949204,Finasteride disrupts prostate cancer,2779,The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.,"Is the triple ""Finasteride disrupts prostate cancer"" supported by the sentence: ""The study was closed 15 months before the final anticipated participant biopsy by the independent Data and Safety Monitoring Committee due to a 24.8% reduction in prostate cancer with finasteride.""?",False, +7931250,Finasteride disrupts alopecia,2780,Finasteride can also be used to stop male baldness.,"Is the triple ""Finasteride disrupts alopecia"" supported by the sentence: ""Finasteride can also be used to stop male baldness.""?",False, +11279550,Finasteride prevents benign prostatic hyperplasia,2781,Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.,"Is the triple ""Finasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone.""?",False, +8938663,Finasteride prevents alopecia,2782,It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.,"Is the triple ""Finasteride prevents alopecia"" supported by the sentence: ""It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage.""?",False, +7857569,Finasteride prevents prostate cancer,2783,Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.,"Is the triple ""Finasteride prevents prostate cancer"" supported by the sentence: ""Finasteride is commonly used for the treatment of benign prostatic hyperplasia and has been suggested to prevent prostate cancer development.""?",False, +9840634,Finasteride predisposes prostate cancer,2784,"Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).","Is the triple ""Finasteride predisposes prostate cancer"" supported by the sentence: ""Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99).""?",False, +8913536,Finasteride predisposes benign prostatic hyperplasia,2785,"CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.","Is the triple ""Finasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSIONS: The present analysis from PLESS demonstrates that in both older (65 years old or older) and younger men with symptomatic BPH and enlarged prostates, finasteride is highly effective in improving symptoms and reducing prostate volume in many men and in reducing the risk of acute urinary retention and BPH-related surgery.""?",False, +15677403,Dutasteride related to benign prostatic hyperplasia,2786,"CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.","Is the triple ""Dutasteride related to benign prostatic hyperplasia"" supported by the sentence: ""CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate.""?",False, +14665250,Dutasteride related to prostate cancer,2787,"Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.","Is the triple ""Dutasteride related to prostate cancer"" supported by the sentence: ""Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.""?",False, +22506276,Dutasteride causes prostatitis,2788,Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.,"Is the triple ""Dutasteride causes prostatitis"" supported by the sentence: ""Dutasteride was administrated at a dose of 0.5 mg/kg daily from 2 days before induction of prostatic inflammation whereas placebo rats received vehicle only.""?",False, +14995448,Dutasteride affects prostate cancer,2789,"Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.","Is the triple ""Dutasteride affects prostate cancer"" supported by the sentence: ""Thus, the effect of dutasteride on prostate cancer may have implications for its potential use as a secondary chemoprevention agent.""?",False, +11407079,Dutasteride affects prostatitis,2790,"Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.","Is the triple ""Dutasteride affects prostatitis"" supported by the sentence: ""Genetic and protein biomarkers of prostate cancer, and the effect of dutasteride on benign prostatic hyperplasia and prostatitis symptomatology and histopathology will also be assessed.""?",False, +10333399,Dutasteride affects benign prostatic hyperplasia,2791,"OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.","Is the triple ""Dutasteride affects benign prostatic hyperplasia"" supported by the sentence: ""OBJECTIVES: To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol.""?",False, +15838005,Dutasteride disrupts prostate cancer,2792,"BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.","Is the triple ""Dutasteride disrupts prostate cancer"" supported by the sentence: ""BACKGROUND: The REDUCE trial examined whether chemoprevention with the dual 5-alpha reductase inhibitor, dutasteride, reduced risk of prostate cancer (PCa) detection on biopsy.""?",False, +16876475,Dutasteride prevents benign prostatic hyperplasia,2793,"On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).","Is the triple ""Dutasteride prevents benign prostatic hyperplasia"" supported by the sentence: ""On multivariable regression analysis adjusting for covariates, dutasteride significantly reduced clinical progression of benign prostatic hyperplasia with an odds ratio of 0.47 (95% CI 0.37 to 0.59, P<0.001).""?",False, +13018366,Dutasteride prevents alopecia,2794,"CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.","Is the triple ""Dutasteride prevents alopecia"" supported by the sentence: ""CONCLUSION: Through the use of identical twins, this randomized trial provides evidence that dutasteride significantly reduces hair loss progression in men with male pattern hair loss.""?",False, +12506526,Dutasteride prevents prostate cancer,2795,"Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.","Is the triple ""Dutasteride prevents prostate cancer"" supported by the sentence: ""Additionally, dutasteride is now under study for the ability to reduce the incidence of prostate cancer in men at high risk of the disease--an indication where the unique dual inhibitor nature, half-life and tolerability of dutasteride may be especially significant factors in determining treatment success.""?",False, +13749427,Dutasteride predisposes benign prostatic hyperplasia,2796,The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.,"Is the triple ""Dutasteride predisposes benign prostatic hyperplasia"" supported by the sentence: ""The Combination of Avodart and Tamsulosin (CombAT) study is currently evaluating the combination of dutasteride with tamsulosin over 4 years in a population of men at increased risk of BPH progression.""?",False, +13628345,Dutasteride predisposes prostate cancer,2797,Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.,"Is the triple ""Dutasteride predisposes prostate cancer"" supported by the sentence: ""Dutasteride is being investigated for its efficacy in reducing the risk of prostate cancer in at-risk men in the 4-year REDUCE study and as treatment to extend the time to progression in men with low-risk localized prostate cancer who would otherwise undergo watchful waiting in the 3-year REDEEM study.""?",False, +23122900,Celecoxib related to Pain,2798,"The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.","Is the triple ""Celecoxib related to Pain"" supported by the sentence: ""The patient was started on prednisone, celecoxib and opioids with minimal improvement in pain and function.""?",False, +20821764,Celecoxib related to prostate cancer,2799,"Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.","Is the triple ""Celecoxib related to prostate cancer"" supported by the sentence: ""Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer.""?",False, +14485082,Celecoxib related to castration-resistant prostate carcinoma,2800,"Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.","Is the triple ""Celecoxib related to castration-resistant prostate carcinoma"" supported by the sentence: ""Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.""?",False, +14288130,Celecoxib related to neoplasm,2801,"Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).","Is the triple ""Celecoxib related to neoplasm"" supported by the sentence: ""Celecoxib administration decreased mammary tumor incidence (by 24%), while combination of celecoxib and melatonin decreased tumor incidence even more significantly (-30%).""?",False, +15210658,Celecoxib related to Cyclooxygenase 2,2802,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, +15210658,Celecoxib related to Cyclooxygenase 2,2803,"Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.","Is the triple ""Celecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Intravesical gene therapy treatments utilizing expression-targeted plasmids, where the murine cyclooxygenase-2 (Cox-2) promoter was used to drive the expression of exogenously inducible forms of caspases 3 and 9, were compared with treatment modalities employing Bacille Calmette-Guerin (BCG) and celecoxib.""?",False, +11056859,Celecoxib coexists with Cyclooxygenase 2,2804,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, +11056859,Celecoxib coexists with Cyclooxygenase 2,2805,"At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells.""?",False, +19664582,Celecoxib coexists with Cyclooxygenase 2,2806,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, +19664582,Celecoxib coexists with Cyclooxygenase 2,2807,"In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.","Is the triple ""Celecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In conclusion, COX-2 and p-ERK1/2 protein may serve as potential targets for GBC chemotherapy, and the combination of celecoxib and PD184161 could significantly inhibit GBC cell growth, induce cell G1 arrest and trigger cell apoptosis of GBC cells.""?",False, +8460221,Celecoxib physically interacts with Cyclooxygenase 2,2808,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, +9140190,Celecoxib physically interacts with Cyclooxygenase 2,2809,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Celecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, +22101111,Celecoxib causes Alzheimer disease,2810,"In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).","Is the triple ""Celecoxib causes Alzheimer disease"" supported by the sentence: ""In vivo, streptozotocin induced AD in mice model was established and Hibiscus extracts were tested at a dose of 200 mg kg -1 compared to celecoxib (30 mg/kg).""?",False, +21110777,Celecoxib causes schizophrenia,2811,"We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.","Is the triple ""Celecoxib causes schizophrenia"" supported by the sentence: ""We also report the possibility of targeting key genes belonging to celecoxib pharmacodynamics, Galpha signalling and cGMP-PKG signalling pathwaysthat are not known to be specific to SZ aetiology.""?",False, +20555672,Celecoxib causes hepatocellular carcinoma,2812,"The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.","Is the triple ""Celecoxib causes hepatocellular carcinoma"" supported by the sentence: ""The results revealed that if celecoxib was administered in the early stage of AKT/c-Met-induced HCC, it resulted in disease stabilization.""?",False, +14478589,Celecoxib causes Inflammation,2813,"In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.","Is the triple ""Celecoxib causes Inflammation"" supported by the sentence: ""In conclusion, these data suggest that even in the presence of cyclosporine A and sirolimus, topical celecoxib treatment can result in reduced inflammation, tumor number and size; properties which may be beneficial in the therapeutic reduction of skin cancer development in solid organ transplant recipients.""?",False, +14396158,Celecoxib causes neoplasm,2814,"In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.","Is the triple ""Celecoxib causes neoplasm"" supported by the sentence: ""In FVB mice, celecoxib prevents 85% of azoxymethane-induced tumors >1 mm in size, but is essentially inactive in preventing tumor induction in 15-PGDH-null animals.""?",False, +13894212,Celecoxib causes peptic ulcer disease,2815,"AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.","Is the triple ""Celecoxib causes peptic ulcer disease"" supported by the sentence: ""AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.""?",False, +13829410,Celecoxib causes Pain,2816,"Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.","Is the triple ""Celecoxib causes Pain"" supported by the sentence: ""Twenty-four hours prior to pain induction with subcutaneous injection of 5% formalin into the hind paw, acetylsalicylic acid or celecoxib was administered to the animals of similar one-, four-, and seven-day pain groups.""?",False, +12882318,Celecoxib causes colorectal neoplasm,2817,"We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.","Is the triple ""Celecoxib causes colorectal neoplasm"" supported by the sentence: ""We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.""?",False, +12147702,Celecoxib causes osteoarthritis,2818,"CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.","Is the triple ""Celecoxib causes osteoarthritis"" supported by the sentence: ""CONCLUSION: The present study showed a chondroneutral effect of celecoxib on the characteristics of experimentally induced OA in vivo, in contrast to the observed beneficial effect in vitro.""?",False, +12029200,Celecoxib causes Hemorrhage,2819,"Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.","Is the triple ""Celecoxib causes Hemorrhage"" supported by the sentence: ""Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz.""?",False, +10018014,Celecoxib causes hypertensive disorder,2820,"A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.","Is the triple ""Celecoxib causes hypertensive disorder"" supported by the sentence: ""A COX-2 inhibitor, celecoxib, interferes with myocardial prostacyclin production and also produces hypertension.""?",False, +25555760,Celecoxib affects postpartum depression,2821,"METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.","Is the triple ""Celecoxib affects postpartum depression"" supported by the sentence: ""METHODS: This was a randomized, double-blind, placebo-controlled trial to investigate the effects of adjunctive celecoxib with CBT on postpartum depression.""?",False, +21116356,Celecoxib affects major depressive disorder,2822,"This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.","Is the triple ""Celecoxib affects major depressive disorder"" supported by the sentence: ""This paper discusses the hypothesized role of inflammation in major depression and schizophrenia, including markers of inflammation; pertinent studies on celecoxib and aspirin; and additional immunomodulatory therapeutic strategies.""?",False, +19634803,Celecoxib affects Hemorrhage,2823,Therapy: Celecoxib reduces risk of ulcer bleeding.,"Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""Therapy: Celecoxib reduces risk of ulcer bleeding.""?",False, +18087191,Celecoxib affects breast neoplasm,2824,The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.,"Is the triple ""Celecoxib affects breast neoplasm"" supported by the sentence: ""The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors.""?",False, +17669654,Celecoxib affects glioma,2825,Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.,"Is the triple ""Celecoxib affects glioma"" supported by the sentence: ""Our findings suggest that the combination therapy of anti-CD40 mAb with celecoxib enhances anti-glioma activities via promotion of type-1 immunity both in myeloid cells and T-cells.""?",False, +17634409,Celecoxib affects depressive disorder,2826,Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.,"Is the triple ""Celecoxib affects depressive disorder"" supported by the sentence: ""Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests.""?",False, +16787676,Celecoxib affects hypertensive disorder,2827,CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.,"Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""CONCLUSION: Celecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases.""?",False, +15889622,Celecoxib affects osteoarthritis,2828,"Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.","Is the triple ""Celecoxib affects osteoarthritis"" supported by the sentence: ""Celecoxib was shown to affect all structures involved in OA pathogenesis: cartilage, bone, and synovium.""?",False, +13667242,Celecoxib affects obesity disorder,2829,"CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.","Is the triple ""Celecoxib affects obesity disorder"" supported by the sentence: ""CONCLUSIONS: The specific inhibition of the cyclooxygenase-2 by celecoxib increased the insulin sensitivity in overweight or obese subjects, without modification in C-reactive protein, homocysteine levels, and metabolic profile.""?",False, +13414910,Celecoxib affects Hemorrhage,2830,"We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).","Is the triple ""Celecoxib affects Hemorrhage"" supported by the sentence: ""We thus conducted a controlled evaluation of the effect of celecoxib on perioperative blood loss, pain relief and consumption of analgesics, range of motion, and subjective outcome in conjunction with total knee replacement (TKR).""?",False, +13122831,Celecoxib affects hypertensive disorder,2831,"However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.","Is the triple ""Celecoxib affects hypertensive disorder"" supported by the sentence: ""However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.""?",False, +12419082,Celecoxib affects neoplasm,2832,"In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""In addition, the effects of this CLX treatment on tumor and adjacent mucosa expression of gastrin, its receptors (CCK2), and COX-1 and COX-2, as well as protein expression of the active form of nuclear factor kappa B (NFkappa B) and the apoptotic-related proteins Bcl-2 and survivin, have been examined.""?",False, +11947530,Celecoxib affects hepatocellular carcinoma,2833,Antitumoral effect of celecoxib in hepatocellular carcinoma.,"Is the triple ""Celecoxib affects hepatocellular carcinoma"" supported by the sentence: ""Antitumoral effect of celecoxib in hepatocellular carcinoma.""?",False, +11444192,Celecoxib affects neoplasm,2834,"Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.","Is the triple ""Celecoxib affects neoplasm"" supported by the sentence: ""Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity.""?",False, +11303331,Celecoxib affects non-small cell lung carcinoma,2835,"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.","Is the triple ""Celecoxib affects non-small cell lung carcinoma"" supported by the sentence: ""Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.""?",False, +10337670,Celecoxib affects colorectal neoplasm,2836,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Celecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, +10157341,Celecoxib affects injury,2837,"Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.","Is the triple ""Celecoxib affects injury"" supported by the sentence: ""Administration of COX inhibitors (celecoxib, indomethacin, ketoprofen) to aspirin-treated rats exacerbated acute injury and abolished adaptation to aspirin.""?",False, +9967873,Celecoxib affects Palmar-plantar erythrodysesthesia syndrome,2838,Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.,"Is the triple ""Celecoxib affects Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.""?",False, +9574485,Celecoxib affects schizophrenia,2839,"METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.","Is the triple ""Celecoxib affects schizophrenia"" supported by the sentence: ""METHOD: In a prospective, double-blind evaluation, 50 patients with an acute exacerbation of schizophrenia were randomly assigned to either risperidone plus celecoxib or risperidone plus placebo.""?",False, +9038473,Celecoxib affects peptic ulcer disease,2840,"The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.","Is the triple ""Celecoxib affects peptic ulcer disease"" supported by the sentence: ""The incidence rates of gastroduodenal ulcers associated with celecoxib were similar, although not equivalent, to placebo.""?",False, +7841958,Celecoxib affects rheumatoid arthritis,2841,Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.,"Is the triple ""Celecoxib affects rheumatoid arthritis"" supported by the sentence: ""Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.""?",False, +7726669,Celecoxib affects Pain,2842,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Pain"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, +7726668,Celecoxib affects Inflammation,2843,"In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.","Is the triple ""Celecoxib affects Inflammation"" supported by the sentence: ""In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.""?",False, +7264055,Celecoxib affects Cyclooxygenase 2,2844,"Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.""?",False, +11464194,Celecoxib affects Cyclooxygenase 2,2845,"In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.","Is the triple ""Celecoxib affects Cyclooxygenase 2"" supported by the sentence: ""In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months.""?",False, +11846592,Celecoxib produces Cyclooxygenase 2,2846,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, +11846592,Celecoxib produces Cyclooxygenase 2,2847,"Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).","Is the triple ""Celecoxib produces Cyclooxygenase 2"" supported by the sentence: ""Pretreatment with celecoxib, a selective COX-2 inhibitor, attenuated Abeta-induced cell death, which was aggravated by addition of the COX-2 product PGE(2).""?",False, +14865798,Celecoxib has input Cyclooxygenase 2,2848,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, +14865798,Celecoxib has input Cyclooxygenase 2,2849,"RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.","Is the triple ""Celecoxib has input Cyclooxygenase 2"" supported by the sentence: ""RESULTS: Treatment of Tca8113 cells with cisplatin (CDDP) had less effect on the expression of COX-2, whereas the COX-2 expression was significantly down-regulated after treatment with celecoxib alone or in combination with CDDP for 24 h.""?",False, +22029254,Celecoxib disrupts major depressive disorder,2850,Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.,"Is the triple ""Celecoxib disrupts major depressive disorder"" supported by the sentence: ""Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.""?",False, +16862201,Celecoxib disrupts hepatocellular carcinoma,2851,"Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.","Is the triple ""Celecoxib disrupts hepatocellular carcinoma"" supported by the sentence: ""Celecoxib, a cyclooxygenase-2 inhibitor, has been shown to inhibit HCC, and we hypothesized that low-dose sorafenib co-administered with celecoxib could act synergistically in the inhibition of HCC.""?",False, +15337601,Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome,2852,"RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).","Is the triple ""Celecoxib disrupts Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""RESULTS: The group that had received capecitabine and celecoxib had a significantly reduced frequency of >grade 1 hand-foot syndrome (29 vs. 72% P < 0.001), and >grade 2 (11.76% vs. 30% P = 0.024).""?",False, +15029907,Celecoxib disrupts Pain,2853,"RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.","Is the triple ""Celecoxib disrupts Pain"" supported by the sentence: ""RESULTS: Compared with placebo, the odds of achieving a 20% reduction in WOMAC pain were celecoxib: 1.21, glucosamine: 1.16, combination glucosamine/CS: 0.83 and CS alone: 0.69, and were not statistically significant.""?",False, +14234726,Celecoxib disrupts adenoma,2854,"Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.","Is the triple ""Celecoxib disrupts adenoma"" supported by the sentence: ""Overall, celecoxib was associated with a dose-dependent reduction in adenoma, compared with placebo, with relative risks (RR) of 0.65 (95% confidence interval [CI]: 0.56-0.76) for the low-dose and 0.54 (95% CI: 0.46-0.63) for the high-dose groups.""?",False, +12025752,Celecoxib disrupts colonic neoplasm,2855,Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.,"Is the triple ""Celecoxib disrupts colonic neoplasm"" supported by the sentence: ""Inhibition of colon tumors by celecoxib was associated with lower levels of COX-2 activity and expression in colon tumors.""?",False, +9589598,Celecoxib disrupts neoplasm,2856,"RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.","Is the triple ""Celecoxib disrupts neoplasm"" supported by the sentence: ""RESULTS: Low doses and high doses of celecoxib significantly lengthened the tumor latency period (P<.03 and P<.003, respectively) and reduced tumor multiplicity (P<.005 and P<.001, respectively) compared with controls.""?",False, +9384934,Celecoxib disrupts breast neoplasm,2857,Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.,"Is the triple ""Celecoxib disrupts breast neoplasm"" supported by the sentence: ""Administration of increasing doses of celecoxib inhibited mammary tumor incidence and multiplicity as well as tumor volume in a dose-dependent manner.""?",False, +8528907,Celecoxib disrupts Inflammation,2858,"Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).","Is the triple ""Celecoxib disrupts Inflammation"" supported by the sentence: ""Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1).""?",False, +19393781,Celecoxib prevents stroke disorder,2859,"Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].","Is the triple ""Celecoxib prevents stroke disorder"" supported by the sentence: ""Incidence of stroke was decreased by celecoxib when compared with all NSAIDs, nsNSAIDs, and COXIBs [(OR: 0.603, 95% CI: 0.410-0.887), (OR: 0.517, 95% CI: 0.287-0.929), and (OR: 0.509, 95% CI: 0.280-0.925), respectively].""?",False, +18309561,Celecoxib prevents hepatocellular carcinoma,2860,"In addition, celecoxib was found to significantly reduce HCC progression.","Is the triple ""Celecoxib prevents hepatocellular carcinoma"" supported by the sentence: ""In addition, celecoxib was found to significantly reduce HCC progression.""?",False, +17468664,Celecoxib prevents non-small cell lung carcinoma,2861,"In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.","Is the triple ""Celecoxib prevents non-small cell lung carcinoma"" supported by the sentence: ""In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC.""?",False, +16386169,Celecoxib prevents actinic keratosis,2862,QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?,"Is the triple ""Celecoxib prevents actinic keratosis"" supported by the sentence: ""QUESTION: Can celecoxib reduce the incidence of actinic keratoses (AKs) and keratinocytic cancers?""?",False, +16323754,Celecoxib prevents hypertensive disorder,2863,"RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.","Is the triple ""Celecoxib prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Apocynin, Mito-TEMPO, and Celecoxib treatments prevented Ang II-induced hypertension, the increased vasoconstrictor responses to phenylephrine, and the reduced acetylcholine relaxation.""?",False, +15947575,Celecoxib prevents osteoarthritis,2864,"OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.","Is the triple ""Celecoxib prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: To determine whether ""continuous"" celecoxib is more efficacious than ""intermittent"" use in preventing osteoarthritis (OA) flares of the knee and/or hip.""?",False, +15337603,Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome,2865,"CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.","Is the triple ""Celecoxib prevents Palmar-plantar erythrodysesthesia syndrome"" supported by the sentence: ""CONCLUSIONS: From the result of this study, we could learn that celecoxib could reduce HFS that was induced by capecitabine.""?",False, +14688780,Celecoxib prevents Low back pain,2866,RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.,"Is the triple ""Celecoxib prevents Low back pain"" supported by the sentence: ""RESULTS: Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score.""?",False, +13346756,Celecoxib prevents prostate cancer,2867,A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.,"Is the triple ""Celecoxib prevents prostate cancer"" supported by the sentence: ""A combination of atorvastatin and celecoxib may be an effective strategy for the prevention of prostate cancer.""?",False, +12969778,Celecoxib prevents neuroblastoma,2868,Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.,"Is the triple ""Celecoxib prevents neuroblastoma"" supported by the sentence: ""Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.""?",False, +12687466,Celecoxib prevents adenoma,2869,Risks and benefits of celecoxib to prevent recurrent adenomas.,"Is the triple ""Celecoxib prevents adenoma"" supported by the sentence: ""Risks and benefits of celecoxib to prevent recurrent adenomas.""?",False, +11060421,Celecoxib prevents classic familial adenomatous polyposis,2870,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Celecoxib prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, +10931690,Celecoxib prevents breast neoplasm,2871,"The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.","Is the triple ""Celecoxib prevents breast neoplasm"" supported by the sentence: ""The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.""?",False, +10337661,Celecoxib prevents colorectal neoplasm,2872,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Celecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, +9969498,Celecoxib prevents Acute Pain,2873,"Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.","Is the triple ""Celecoxib prevents Acute Pain"" supported by the sentence: ""Within the first 24 hours, celecoxib at a dose of 200 or 400 mg/d significantly reduced the amount of acute pain experienced compared with placebo for four of the five measures, and statistical significance for the remaining parameter, ""pain in the last 24 hours,"" was achieved on day 2.""?",False, +9525867,Celecoxib prevents injury,2874,Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.,"Is the triple ""Celecoxib prevents injury"" supported by the sentence: ""Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.""?",False, +9508533,Celecoxib prevents Pain,2875,IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.,"Is the triple ""Celecoxib prevents Pain"" supported by the sentence: ""IMPLICATIONS: Oral premedication with a combination of acetaminophen (2000 mg) and celecoxib (200 mg) was effective in decreasing pain and improving patient satisfaction after otolaryngologic surgery.""?",False, +8844228,Celecoxib prevents Inflammation,2876,"Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.","Is the triple ""Celecoxib prevents Inflammation"" supported by the sentence: ""Celecoxib (25 mg/kg per day) significantly reduced the inflammation, the local PGE2 production, and osteolysis.""?",False, +7720173,Celecoxib prevents neoplasm,2877,The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.,"Is the triple ""Celecoxib prevents neoplasm"" supported by the sentence: ""The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.""?",False, +14426267,Celecoxib predisposes Inflammation,2878,"In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.","Is the triple ""Celecoxib predisposes Inflammation"" supported by the sentence: ""In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect.""?",False, +12799788,Celecoxib predisposes hypertensive disorder,2879,"Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.","Is the triple ""Celecoxib predisposes hypertensive disorder"" supported by the sentence: ""Concerning the risk of arterial hypertension, aedemas or congestive cardiac insufficiency, a meta-analysis and a randomised trial have shown a deleterious effect of rofecoxib in comparison with celecoxib and non-specific NSAIDs.""?",False, +11130431,Celecoxib predisposes injury,2880,CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.,"Is the triple ""Celecoxib predisposes injury"" supported by the sentence: ""CONCLUSIONS: Short-term use of the nonselective COX inhibitors ibuprofen and naproxen is associated with a greater risk for endoscopic mucosal injury compared with the COX-2-selective inhibitor celecoxib or placebo.""?",False, +12352394,Rofecoxib related to Cyclooxygenase 2,2881,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, +12352394,Rofecoxib related to Cyclooxygenase 2,2882,"Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.""?",False, +14685035,Rofecoxib related to Cyclooxygenase 2,2883,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, +14685035,Rofecoxib related to Cyclooxygenase 2,2884,"We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.","Is the triple ""Rofecoxib related to Cyclooxygenase 2"" supported by the sentence: ""We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo.""?",False, +8460222,Rofecoxib physically interacts with Cyclooxygenase 2,2885,Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.,"Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.""?",False, +9140191,Rofecoxib physically interacts with Cyclooxygenase 2,2886,"Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.","Is the triple ""Rofecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development.""?",False, +10265772,Rofecoxib causes Pain,2887,We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.,"Is the triple ""Rofecoxib causes Pain"" supported by the sentence: ""We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy.""?",False, +13140649,Rofecoxib affects Pain,2888,"Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.","Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation, fatigue, fever, weight loss, and pain, and analgesic consumption.""?",False, +13143485,Rofecoxib affects osteoarthritis,2889,Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study).""?",False, +12129893,Rofecoxib affects adenoma,2890,Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.,"Is the triple ""Rofecoxib affects adenoma"" supported by the sentence: ""Rofecoxib in lower doses had the same effect on adenomas (p < 0.05) with no effect on adenocarcinomas.""?",False, +11539323,Rofecoxib affects Pain,2891,Effect of rofecoxib on pain caused by osteoid osteoma.,"Is the triple ""Rofecoxib affects Pain"" supported by the sentence: ""Effect of rofecoxib on pain caused by osteoid osteoma.""?",False, +10337671,Rofecoxib affects colorectal neoplasm,2892,"We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).","Is the triple ""Rofecoxib affects colorectal neoplasm"" supported by the sentence: ""We examined the effect of the selective cyclooxygenase-2 inhibitors rofecoxib and celecoxib, nonselective nonsteroidal anti-inflammatory drugs, aspirin, and acetaminophen on colorectal neoplasia (colorectal cancer, colorectal adenoma, or both).""?",False, +8436303,Rofecoxib affects osteoarthritis,2893,The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.,"Is the triple ""Rofecoxib affects osteoarthritis"" supported by the sentence: ""The absence of a significant effect of rofecoxib on intestinal permeability at doses at least twice those recommended to treat osteoarthritis was consistent with other studies that have demonstrated little or no injury to the gastrointestinal mucosa associated with rofecoxib therapy.""?",False, +7546790,Rofecoxib affects Cyclooxygenase 2,2894,"Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Using the ratio of the COX-1 IC(50) values over the COX-2 IC(50) values in the human whole blood assay, selectivity ratios for the inhibition of COX-2 of 36, 6.6, 2, 3, and 0.4 were obtained for rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin, respectively.""?",False, +11143316,Rofecoxib affects Cyclooxygenase 2,2895,"Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.","Is the triple ""Rofecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.""?",False, +11899486,Rofecoxib disrupts Pain,2896,Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.,"Is the triple ""Rofecoxib disrupts Pain"" supported by the sentence: ""Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair.""?",False, +12422414,Rofecoxib prevents adenoma,2897,BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.,"Is the triple ""Rofecoxib prevents adenoma"" supported by the sentence: ""BACKGROUND: The cardiovascular safety of cyclooxygenase (COX)-2-selective nonsteroidal antiinflammatory drugs (NSAIDs) has come under scrutiny after the withdrawal of rofecoxib and halting of the Adenoma Prevention with Celecoxib trial.""?",False, +10337662,Rofecoxib prevents colorectal neoplasm,2898,The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.,"Is the triple ""Rofecoxib prevents colorectal neoplasm"" supported by the sentence: ""The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence.""?",False, +9488144,Rofecoxib prevents Pain,2899,"This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.","Is the triple ""Rofecoxib prevents Pain"" supported by the sentence: ""This study was designed to assess the efficacy of preoperative administration of rofecoxib (Vioxx; Merck & Co., Inc., Somerset, NJ) in reducing pain and opioid requirements after single-level lumbar microdiscectomy.""?",False, +12808149,Rofecoxib predisposes adenoma,2900,Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).,"Is the triple ""Rofecoxib predisposes adenoma"" supported by the sentence: ""Rofecoxib also conferred a reduction in risk of advanced adenomas (P < .01).""?",False, +21440548,Etoricoxib affects osteoarthritis,2901,"In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.","Is the triple ""Etoricoxib affects osteoarthritis"" supported by the sentence: ""In conclusion, our study confirmed the chondro-protective role of etoricoxib in OA, and proved the curative effects of etoricoxib-loaded PLGA-PEG-PLGA NPs in vivo.""?",False, +17783506,Etoricoxib affects injury,2902,The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.,"Is the triple ""Etoricoxib affects injury"" supported by the sentence: ""The purpose of this study was to investigate the effect of etoricoxib on oxidative injury induced with ischemia-reperfusion (I/R) in rat kidney tissue in terms of biochemistry and immunohistochemistry.""?",False, +15015650,Etoricoxib affects Pain,2903,DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.,"Is the triple ""Etoricoxib affects Pain"" supported by the sentence: ""DISCUSSION: The results of this study will provide information on the analgesic effectiveness of etoricoxib in preemptive analgesia and will give hints on possible preventive effects of persistent pain.""?",False, +13276651,Etoricoxib affects rheumatic disorder,2904,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Etoricoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, +8656381,Etoricoxib affects Cyclooxygenase 2,2905,"In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.","Is the triple ""Etoricoxib affects Cyclooxygenase 2"" supported by the sentence: ""In summary, etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents.""?",False, +21271381,Etoricoxib prevents osteoarthritis,2906,The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.,"Is the triple ""Etoricoxib prevents osteoarthritis"" supported by the sentence: ""The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-beta1 and NGF expressions in chondrocytes.""?",False, +17783508,Etoricoxib prevents injury,2907,The results of this study show that etoricoxib treatment could decrease kidney injury during IR.,"Is the triple ""Etoricoxib prevents injury"" supported by the sentence: ""The results of this study show that etoricoxib treatment could decrease kidney injury during IR.""?",False, +13679347,Etoricoxib prevents Pain,2908,CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.,"Is the triple ""Etoricoxib prevents Pain"" supported by the sentence: ""CONCLUSION: A single oral dose of etoricoxib for reduction of pain during endometrial biopsy had not significantly lower the pain score during the procedure compared with the placebo.""?",False, +11619190,Lumiracoxib coexists with Cyclooxygenase 2,2909,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, +11619190,Lumiracoxib coexists with Cyclooxygenase 2,2910,"In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).","Is the triple ""Lumiracoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""In cellular assays, lumiracoxib had an IC(50) of 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).""?",False, +17164065,Lumiracoxib physically interacts with Cyclooxygenase 2,2911,The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.,"Is the triple ""Lumiracoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The positioning of critical substituents in the binding site was identified from a 2.35A crystal structure of lumiracoxib bound to COX-2.""?",False, +13276652,Lumiracoxib affects rheumatic disorder,2912,"This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.","Is the triple ""Lumiracoxib affects rheumatic disorder"" supported by the sentence: ""This review examines the role of the newest COX-2 selective inhibitors, etoricoxib and lumiracoxib, in treating rheumatic disease.""?",False, +10245332,Lumiracoxib affects Cyclooxygenase 2,2913,"Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.","Is the triple ""Lumiracoxib affects Cyclooxygenase 2"" supported by the sentence: ""Lumiracoxib, an inhibitor of cyclooxygenase 2 (COX-2), is under development by Novartis for the potential treatment of osteoarthritis, rheumatoid arthritis and pain.""?",False, +13077914,Valdecoxib physically interacts with Cyclooxygenase 2,2914,We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.,"Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""We therefore conclude that valdecoxib specifically interacts with COX-2 and induces a conformation accessible for ubiquitination and degradation.""?",False, +11476053,Valdecoxib physically interacts with Cyclooxygenase 2,2915,"Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).","Is the triple ""Valdecoxib physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).""?",False, +9552647,Valdecoxib affects Cyclooxygenase 2,2916,"Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].","Is the triple ""Valdecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].""?",False, +11215677,Valdecoxib disrupts Pain,2917,Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.,"Is the triple ""Valdecoxib disrupts Pain"" supported by the sentence: ""Valdecoxib had opioid-sparing effects after hip or knee arthroplasty and reduced pain after laparoscopic cholecystectomy.""?",False, +15156435,Valdecoxib prevents pancreatitis,2918,CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.,"Is the triple ""Valdecoxib prevents pancreatitis"" supported by the sentence: ""CONCLUSIONS: Valdecoxib and GTN were not effective for the prevention of post-ERCP pancreatitis.""?",False, +10035578,Valdecoxib prevents Pain,2919,"Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.","Is the triple ""Valdecoxib prevents Pain"" supported by the sentence: ""Thus, valdecoxib in combination with morphine provides multi-modal analgesia that reduces pain and opioid use and increases patient satisfaction following knee replacement surgery.""?",False, +17909160,Parecoxib coexists with Cyclooxygenase 2,2920,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, +17909160,Parecoxib coexists with Cyclooxygenase 2,2921,"On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.","Is the triple ""Parecoxib coexists with Cyclooxygenase 2"" supported by the sentence: ""On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.""?",False, +16597136,Parecoxib affects Shoulder pain,2922,BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.,"Is the triple ""Parecoxib affects Shoulder pain"" supported by the sentence: ""BACKGROUND: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.""?",False, +13492238,Parecoxib affects Pain,2923,Preventive effects of perioperative parecoxib on post-discectomy pain.,"Is the triple ""Parecoxib affects Pain"" supported by the sentence: ""Preventive effects of perioperative parecoxib on post-discectomy pain.""?",False, +12600950,Parecoxib affects Cyclooxygenase 2,2924,Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.,"Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice.""?",False, +18579418,Parecoxib affects Cyclooxygenase 2,2925,"While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).","Is the triple ""Parecoxib affects Cyclooxygenase 2"" supported by the sentence: ""While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05).""?",False, +18207264,Parecoxib disrupts Pain,2926,"Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).","Is the triple ""Parecoxib disrupts Pain"" supported by the sentence: ""Parecoxib significantly reduced cumulative opioid consumption by 24% (43 +/- 24.1 mg versus 57 +/- 28 mg, mean +/- SD, p=0.02), translating into improved benefit of analgesia (OBAS: 2(0/4) versus 3(1/5.25), p=0.01), pain severity (m-BPI-sf: 1(1/2) versus 2(2/3), p < 0.01) and pain interference (m-BPI-sf: 1(0/1) versus 1(1/3), p=0.001), as well as reduced opioid-related side effects (OR-SDS score: 0.3(0.075/0.51) versus 0.4(0.2/0.83), p=0.03).""?",False, +16597135,Parecoxib prevents Shoulder pain,2927,"Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.","Is the triple ""Parecoxib prevents Shoulder pain"" supported by the sentence: ""Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.""?",False, +14081775,Parecoxib prevents Pain,2928,RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.,"Is the triple ""Parecoxib prevents Pain"" supported by the sentence: ""RESULTS: Parecoxib reduced pain scores at 6 h and morphine use at 6 and 12 h after operation.""?",False, +22281663,Drospirenone related to polycystic ovary syndrome,2929,"METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.","Is the triple ""Drospirenone related to polycystic ovary syndrome"" supported by the sentence: ""METHODS: In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP.""?",False, +21546756,Drospirenone related to acne,2930,"Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).","Is the triple ""Drospirenone related to acne"" supported by the sentence: ""Our results showed that the use of OCs containing DRSP for 6 months was associated with more improvement in acne, compared with products containing LNG (P = 0.007).""?",False, +20964606,Drospirenone predisposes polycystic ovary syndrome,2931,"Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.","Is the triple ""Drospirenone predisposes polycystic ovary syndrome"" supported by the sentence: ""Hormonal treatment with oral contraceptives, containing estrogen (ethinyl-estradiol, EE) with progestogen (drospirenone, DRSP) or (chlormadinone acetate, CMA), has improved symptoms and biomarkers of PCOS.""?",False, +8455182,Ropinirole related to Parkinson disease,2932,Ropinirole as compared with levodopa in Parkinson's disease.,"Is the triple ""Ropinirole related to Parkinson disease"" supported by the sentence: ""Ropinirole as compared with levodopa in Parkinson's disease.""?",False, +17774585,Ropinirole causes Parkinson disease,2933,"Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.","Is the triple ""Ropinirole causes Parkinson disease"" supported by the sentence: ""Ceftriaxone (100 and 200mg/kg) and Ropinirole (1.5 and 3mg/kg) were given intraperitonially, after induction of Parkinson's disease for 14 days.""?",False, +14587825,Ropinirole affects Parkinson disease,2934,An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.,"Is the triple ""Ropinirole affects Parkinson disease"" supported by the sentence: ""An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.""?",False, +11791368,Ropinirole affects restless legs syndrome,2935,The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.,"Is the triple ""Ropinirole affects restless legs syndrome"" supported by the sentence: ""The symptoms of restless legs syndrome are responsive to dopaminergic agents such as ropinirole.""?",False, +9334943,Ropinirole disrupts Parkinson disease,2936,"A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).","Is the triple ""Ropinirole disrupts Parkinson disease"" supported by the sentence: ""A dose-ratio of bromocriptine to ropinirole of close to 2:1 (1.87; mean ropinirole dose: 10.1 +/- 2.5 mg/d) was the only dose that significantly reduced mean motor Unified Parkinson's Disease Rating Scale (UPDRS) scores ( p = 0.030, analysis of variance).""?",False, +10286489,Ropinirole prevents Parkinson disease,2937,"Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.","Is the triple ""Ropinirole prevents Parkinson disease"" supported by the sentence: ""Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using (18)F-dopa positron emission tomography (PET) suggested a slower loss of striatal dopamine storage with ropinirole compared with levodopa.""?",False, +27727471,Pergolide related to Parkinson disease,2938,Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.,"Is the triple ""Pergolide related to Parkinson disease"" supported by the sentence: ""Formal studies examining the antiparkinsonian efficacy of levodopa and pergolide monotherapy in de novo Parkinson's disease (PD) are lacking.""?",False, +11914502,Pergolide causes Parkinson disease,2939,"The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.","Is the triple ""Pergolide causes Parkinson disease"" supported by the sentence: ""The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial.""?",False, +10881399,Pergolide affects Parkinson disease,2940,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pergolide affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, +16163315,Bromocriptine related to Parkinson disease,2941,Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.,"Is the triple ""Bromocriptine related to Parkinson disease"" supported by the sentence: ""Bromocriptine and levodopa in early combination in Parkinson's disease: first results of the Collaborative European Multicentric Trial.""?",False, +15233295,Bromocriptine related to type 1 diabetes mellitus,2942,Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.,"Is the triple ""Bromocriptine related to type 1 diabetes mellitus"" supported by the sentence: ""Interaction of bromocriptine and cyclosporine in insulin dependent diabetes mellitus: results from the Canadian open study.""?",False, +17352665,Bromocriptine causes obesity disorder,2943,"SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.","Is the triple ""Bromocriptine causes obesity disorder"" supported by the sentence: ""SIGNIFICANCE: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood.""?",False, +12630193,Bromocriptine causes Parkinson disease,2944,"The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.","Is the triple ""Bromocriptine causes Parkinson disease"" supported by the sentence: ""The present study has been designed to evaluate the combined effect of bromocriptine (BRC) and Hypericum perforatum extract (HPE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in male Swiss Albino mice, which were randomly divided into seven groups of six animals each.""?",False, +22488533,Bromocriptine affects adenomyosis,2945,The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.,"Is the triple ""Bromocriptine affects adenomyosis"" supported by the sentence: ""The changes seen in this small pilot study may indicate that vaginal bromocriptine have an impact on adenomyosis that is reflected in radiological appearance.""?",False, +20888778,Bromocriptine affects Parkinson disease,2946,"Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.","Is the triple ""Bromocriptine affects Parkinson disease"" supported by the sentence: ""Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated.""?",False, +27647530,Bromocriptine prevents obesity disorder,2947,"Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.","Is the triple ""Bromocriptine prevents obesity disorder"" supported by the sentence: ""Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.""?",False, +15529387,Bromocriptine prevents ovarian hyperstimulation syndrome,2948,Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.,"Is the triple ""Bromocriptine prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Dopamine agonist bromocriptine for the prevention of ovarian hyperstimulation syndrome.""?",False, +18216941,Piribedil causes Parkinson disease,2949,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Piribedil causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, +8408670,Piribedil affects Parkinson disease,2950,Action of piribedil in Parkinson's disease: I.V. test and oral treatment.,"Is the triple ""Piribedil affects Parkinson disease"" supported by the sentence: ""Action of piribedil in Parkinson's disease: I.V. test and oral treatment.""?",False, +8818724,Apomorphine related to Parkinson disease,2951,The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine related to Parkinson disease"" supported by the sentence: ""The published data deal mainly with the acute administration of levodopa and apomorphine in Parkinson's disease.""?",False, +23018637,Apomorphine causes erectile dysfunction,2952,Apomorphine was used to induce diabetic erectile dysfunction.,"Is the triple ""Apomorphine causes erectile dysfunction"" supported by the sentence: ""Apomorphine was used to induce diabetic erectile dysfunction.""?",False, +11364291,Apomorphine causes Parkinson disease,2953,"Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.","Is the triple ""Apomorphine causes Parkinson disease"" supported by the sentence: ""Subcutaneous apomorphine is currently used for the management of sudden, unexpected and refractory levodopa-induced 'off' states in fluctuating Parkinson's disease either as intermittent rescue injections or continuous infusions.""?",False, +8320181,Apomorphine affects Parkinson disease,2954,The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.,"Is the triple ""Apomorphine affects Parkinson disease"" supported by the sentence: ""The pharmacokinetic and clinical effects of tolcapone on a single dose of sublingual apomorphine in Parkinson's disease.""?",False, +16869339,Cabergoline related to Parkinson disease,2955,OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).,"Is the triple ""Cabergoline related to Parkinson disease"" supported by the sentence: ""OBJECTIVE: To evaluate the effects of levodopa and the dopamine D2 agonist cabergoline on striatal dopamine turnover estimated as the inverse of the effective dopamine distribution volume ratio (EDVR) measured by (18)F-dopa PET in de novo Parkinson disease (PD).""?",False, +19536611,Cabergoline physically interacts with Dopamine D2 Receptor,2956,CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.,"Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""CONCLUSION: The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation.""?",False, +15320456,Cabergoline physically interacts with Dopamine D2 Receptor,2957,"In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.","Is the triple ""Cabergoline physically interacts with Dopamine D2 Receptor"" supported by the sentence: ""In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation.""?",False, +20751353,Cabergoline causes endometriosis,2958,"Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).","Is the triple ""Cabergoline causes endometriosis"" supported by the sentence: ""Three weeks after endometriosis induction, animals were randomly allocated into four groups: Group 1 received cabergoline (CAB group); Group 2 received letrozole (LET group); Group 3 received silymarin (SIL group) and Group 4 received no medication (CONT group).""?",False, +26585560,Cabergoline affects pituitary tumor,2959,The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.,"Is the triple ""Cabergoline affects pituitary tumor"" supported by the sentence: ""The purpose of this study was to investigate the PRL-lowering effect and antitumor effect of CG on estradiol-induced rat pituitary tumors in vitro and to elucidate these mechanisms.""?",False, +19237315,Cabergoline affects endometriosis,2960,Effect of Cabergoline in Experimental Endometriosis in Rats.,"Is the triple ""Cabergoline affects endometriosis"" supported by the sentence: ""Effect of Cabergoline in Experimental Endometriosis in Rats.""?",False, +17463083,Cabergoline affects Dopamine D2 Receptor,2961,Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.,"Is the triple ""Cabergoline affects Dopamine D2 Receptor"" supported by the sentence: ""Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly.""?",False, +12695381,Cabergoline affects ovarian hyperstimulation syndrome,2962,OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.,"Is the triple ""Cabergoline affects ovarian hyperstimulation syndrome"" supported by the sentence: ""OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.""?",False, +13380476,Cabergoline prevents ovarian hyperstimulation syndrome,2963,Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.,"Is the triple ""Cabergoline prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.""?",False, +9194241,Cabergoline predisposes ovarian hyperstimulation syndrome,2964,"CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.","Is the triple ""Cabergoline predisposes ovarian hyperstimulation syndrome"" supported by the sentence: ""CONCLUSION: Our data suggest a dopaminergic control of LH release and support the use of cabergoline in the management of such patients, in order to provide better clinical control of ovarian response and consequently a reduction of the risk of OHSS, with no decrease in pregnancy rate.""?",False, +15982499,Pramipexole related to restless legs syndrome,2965,"Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.","Is the triple ""Pramipexole related to restless legs syndrome"" supported by the sentence: ""Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.""?",False, +9735890,Pramipexole related to Parkinson disease,2966,Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.,"Is the triple ""Pramipexole related to Parkinson disease"" supported by the sentence: ""Review: selegiline improves symptoms and levodopa is better than pramipexole for motor function in untreated Parkinson disease.""?",False, +21401262,Pramipexole causes restless legs syndrome,2967,Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.,"Is the triple ""Pramipexole causes restless legs syndrome"" supported by the sentence: ""Treatment with low dose pramipexole led to improved RLS and marked improvement in his energy.""?",False, +15033700,Pramipexole causes obsessive-compulsive disorder,2968,"CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.","Is the triple ""Pramipexole causes obsessive-compulsive disorder"" supported by the sentence: ""CONCLUSIONS: Like other dopamine agonists, pramipexole may precipitate compulsive behaviors, including hypersexual behavior in the form of compulsive masturbation.""?",False, +13328857,Pramipexole causes Parkinson disease,2969,"We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.","Is the triple ""Pramipexole causes Parkinson disease"" supported by the sentence: ""We report a case of antecollis, or dropped head with Parkinson's disease (PD) induced by pramipexole, a nonergot dopamine agonist.""?",False, +18143671,Pramipexole affects depressive disorder,2970,The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.,"Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD.""?",False, +12990655,Pramipexole affects restless legs syndrome,2971,The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.,"Is the triple ""Pramipexole affects restless legs syndrome"" supported by the sentence: ""The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.""?",False, +12579916,Pramipexole affects depressive disorder,2972,"Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.","Is the triple ""Pramipexole affects depressive disorder"" supported by the sentence: ""Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.""?",False, +10881401,Pramipexole affects Parkinson disease,2973,"We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).","Is the triple ""Pramipexole affects Parkinson disease"" supported by the sentence: ""We compared the antitremor effect of pramipexole, pergolide, or placebo in Parkinson's disease (PD).""?",False, +11457313,Pramipexole prevents Parkinson disease,2974,"Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.","Is the triple ""Pramipexole prevents Parkinson disease"" supported by the sentence: ""Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.""?",False, +24610805,Rotigotine affects Parkinson disease,2975,"A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.","Is the triple ""Rotigotine affects Parkinson disease"" supported by the sentence: ""A meta-analysis evaluating effects of the rotigotine in Parkinson's disease, focusing on sleep disturbances and activities of daily living.""?",False, +10840977,Norethindrone subclass of Norethindrone acetate,2976,"Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.","Is the triple ""Norethindrone subclass of Norethindrone acetate"" supported by the sentence: ""Score changes on this instrument have been used to report statistically significant treatment advantages for a low-dose oral contraceptive (Estrostep, containing norethisterone (norethindrone) acetate (NA) 1mg and ethinylestradiol (EE) [20, 30, 35 mg] as compared with placebo in women with moderate acne vulgaris.""?",False, +8232443,Norethindrone related to Norethindrone acetate,2977,"The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.","Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""The superior cycle control of Alesse compared with Loestrin Fe 1/20 is consistent with that found in comparative studies of the cycle control of levonorgestrel, norethindrone, and norethindrone acetate containing OCs that had a higher dose of EE.""?",False, +11686400,Norethindrone related to Norethindrone acetate,2978,OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).,"Is the triple ""Norethindrone related to Norethindrone acetate"" supported by the sentence: ""OBJECTIVE: To compare 1 mg norethisterone acetate with 5 mg norethindrone when used in conjunction with 2 mg estradiol given as add-back therapy during treatment with a gonadotropin-releasing hormone agonist (GnRHa).""?",False, +9474851,Norethindrone coexists with Norethindrone acetate,2979,"The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.","Is the triple ""Norethindrone coexists with Norethindrone acetate"" supported by the sentence: ""The association with number of years since menopause was counteracted by both 1 and 2 mg estradiol combined with gestodene, piperazine, estrone sulfate in combination with norethisterone, and a combination of 2 mg estradiol and 1 mg norethisterone acetate.""?",False, +9781055,Norethindrone physically interacts with Norethindrone acetate,2980,"Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.","Is the triple ""Norethindrone physically interacts with Norethindrone acetate"" supported by the sentence: ""Estranes, including norethisterone acetate, lynestrenol, norethynodrel, and ethynodiol diacetate, are all related to the base norethisterone and must be metabolized to norethisterone to be active.""?",False, +21462883,Norethindrone causes neoplasm,2981,"Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.","Is the triple ""Norethindrone causes neoplasm"" supported by the sentence: ""Progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs.""?",False, +27429354,Pramocaine affects Pruritus,2982,Effect of topical pramoxine on experimentally induced pruritus in humans.,"Is the triple ""Pramocaine affects Pruritus"" supported by the sentence: ""Effect of topical pramoxine on experimentally induced pruritus in humans.""?",False, +19275366,Miconazole disrupts fungal infectious disease,2983,"Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.","Is the triple ""Miconazole disrupts fungal infectious disease"" supported by the sentence: ""Indeed, miconazole topically added to RHE was demonstrated to inhibit fungal infection in this model.""?",False, +26511975,Miconazole prevents fungal infectious disease,2984,"The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.","Is the triple ""Miconazole prevents fungal infectious disease"" supported by the sentence: ""The imidazoles ketoconazole and miconazole can reduce the incidence of superficial fungal infections, but there are conflicting data regarding their value for prevention of systemic mycoses.""?",False, +26530559,Benzocaine affects Pain,2985,OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.,"Is the triple ""Benzocaine affects Pain"" supported by the sentence: ""OBJECTIVE: Our purpose was to evaluate the effect of cervical application of 20% benzocaine on the pain associated with subsequent cervical injection of local anesthetic and tissue excision during the loop electrosurgical excision procedure of the cervix.""?",False, +8870493,Benzocaine disrupts Pain,2986,CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.,"Is the triple ""Benzocaine disrupts Pain"" supported by the sentence: ""CONCLUSIONS: LDS is more effective than BGP for topical pain suppression to Ns and SRP in both arches.""?",False, +8870496,Benzocaine prevents Pain,2987,"Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.","Is the triple ""Benzocaine prevents Pain"" supported by the sentence: ""Comparing LDS directly with BGP, LDS was significantly (P < 0.05) more effective in reducing pain to Ns in both arches, to SRP in the maxillary arch, and equally effective as BGP in the mandibular arch.""?",False, +25561815,Folic Acid related to systemic lupus erythematosus,2988,Folic acid in systemic lupus erythematosus - a new aspect.,"Is the triple ""Folic Acid related to systemic lupus erythematosus"" supported by the sentence: ""Folic acid in systemic lupus erythematosus - a new aspect.""?",False, +23703706,Folic Acid related to neoplasm of esophagus,2989,"We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.","Is the triple ""Folic Acid related to neoplasm of esophagus"" supported by the sentence: ""We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.""?",False, +23248765,Folic Acid related to chronic renal failure syndrome,2990,"Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.","Is the triple ""Folic Acid related to chronic renal failure syndrome"" supported by the sentence: ""Since elevated plasma homocysteine is associated with premature vascular disease, folic acid may reduce cardiovascular risk in chronic renal insufficiency.""?",False, +20038856,Folic Acid related to psychotic disorder,2991,Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.,"Is the triple ""Folic Acid related to psychotic disorder"" supported by the sentence: ""Synthesis of clinical correlates found both folate and vitamin D held significant inverse relationships with psychiatric symptoms in FEP.""?",False, +19346997,Folic Acid related to myocardial ischemia,2992,"To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.","Is the triple ""Folic Acid related to myocardial ischemia"" supported by the sentence: ""To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids.""?",False, +19301020,Folic Acid related to type 2 diabetes mellitus,2993,"In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.","Is the triple ""Folic Acid related to type 2 diabetes mellitus"" supported by the sentence: ""In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.""?",False, +19114314,Folic Acid related to tuberculosis,2994,Information about folate status in tuberculosis in developing countries is scanty.,"Is the triple ""Folic Acid related to tuberculosis"" supported by the sentence: ""Information about folate status in tuberculosis in developing countries is scanty.""?",False, +18323097,Folic Acid related to HIV infectious disease,2995,"CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.","Is the triple ""Folic Acid related to HIV infectious disease"" supported by the sentence: ""CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection.""?",False, +17591518,Folic Acid related to infertility disorder,2996,Folate is one of the B vitamins which has been suggested to be related to infertility.,"Is the triple ""Folic Acid related to infertility disorder"" supported by the sentence: ""Folate is one of the B vitamins which has been suggested to be related to infertility.""?",False, +15826430,Folic Acid related to male infertility,2997,Folate and vitamin B12 in idiopathic male infertility.,"Is the triple ""Folic Acid related to male infertility"" supported by the sentence: ""Folate and vitamin B12 in idiopathic male infertility.""?",False, +14280104,Folic Acid related to myocardial infarction,2998,"CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.","Is the triple ""Folic Acid related to myocardial infarction"" supported by the sentence: ""CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function.""?",False, +12974622,Folic Acid related to osteoporosis,2999,INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.,"Is the triple ""Folic Acid related to osteoporosis"" supported by the sentence: ""INTRODUCTION: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B12 are associated with risk of osteoporosis and fracture.""?",False, +12112288,Folic Acid related to autism spectrum disorder,3000,"Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.","Is the triple ""Folic Acid related to autism spectrum disorder"" supported by the sentence: ""Plasma and urinary levels of biopterin, neopterin, and related pterins and plasma levels of folate in infantile autism.""?",False, +11305980,Folic Acid related to cleft palate,3001,"The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.","Is the triple ""Folic Acid related to cleft palate"" supported by the sentence: ""The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency.""?",False, +10745702,Folic Acid related to malaria,3002,Administration of pyrimethamine with folic acid and folinic acids in human malaria.,"Is the triple ""Folic Acid related to malaria"" supported by the sentence: ""Administration of pyrimethamine with folic acid and folinic acids in human malaria.""?",False, +10717915,Folic Acid related to habitual spontaneous abortion,3003,SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.,"Is the triple ""Folic Acid related to habitual spontaneous abortion"" supported by the sentence: ""SERUM-FOLIC-ACID IN RECURRENT ABORTIONS.""?",False, +10644755,Folic Acid related to atherosclerosis,3004,[Use of vitamin B12 and folic acid in atherosclerosis].,"Is the triple ""Folic Acid related to atherosclerosis"" supported by the sentence: ""[Use of vitamin B12 and folic acid in atherosclerosis].""?",False, +10226420,Folic Acid related to cervical polyp,3005,"Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.","Is the triple ""Folic Acid related to cervical polyp"" supported by the sentence: ""Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia.""?",False, +10177078,Folic Acid related to colorectal neoplasm,3006,CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.,"Is the triple ""Folic Acid related to colorectal neoplasm"" supported by the sentence: ""CONCLUSIONS: Low folate status and DNA hypomethylation are associated with colorectal neoplasia.""?",False, +10046990,Folic Acid related to depressive disorder,3007,This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.,"Is the triple ""Folic Acid related to depressive disorder"" supported by the sentence: ""This study examined associations between depression and folate status indicators in an ethnically diverse general US population sample aged 15-39 years.""?",False, +9815747,Folic Acid related to hypertensive disorder,3008,"In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.","Is the triple ""Folic Acid related to hypertensive disorder"" supported by the sentence: ""In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension.""?",False, +9628243,Folic Acid related to mesothelioma,3009,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to mesothelioma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, +9628242,Folic Acid related to non-small cell lung carcinoma,3010,"Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.","Is the triple ""Folic Acid related to non-small cell lung carcinoma"" supported by the sentence: ""Subsequent studies described in this article will show that these toxicities can be significantly reduced by the use of vitamin supplementation with folate and B12, and that pemetrexed has considerable activity in non-small cell lung cancer and mesothelioma.""?",False, +9060030,Folic Acid related to neoplasm,3011,Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.,"Is the triple ""Folic Acid related to neoplasm"" supported by the sentence: ""Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.""?",False, +8875457,Folic Acid related to lymphoma,3012,"The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.","Is the triple ""Folic Acid related to lymphoma"" supported by the sentence: ""The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas.""?",False, +8584638,Folic Acid related to sickle cell anemia,3013,Erythrocyte folate does not accurately reflect folate status in sickle cell disease.,"Is the triple ""Folic Acid related to sickle cell anemia"" supported by the sentence: ""Erythrocyte folate does not accurately reflect folate status in sickle cell disease.""?",False, +8274471,Folic Acid related to chronic kidney disease,3014,"In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.","Is the triple ""Folic Acid related to chronic kidney disease"" supported by the sentence: ""In conclusion, folate supplements in ESRD reduce plasma Hcy concentrations and may improve lipid profiles.""?",False, +8259960,Folic Acid related to type 1 diabetes mellitus,3015,"OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.","Is the triple ""Folic Acid related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: Our aim was to study the presence of moderate hyperhomocysteinemia, a risk factor for premature cardiovascular disease, its modifying vitamin factors (folates, vitamins B12 and B6), and lipid risk factors in juvenile type 1 diabetes.""?",False, +8078141,Folic Acid related to Alzheimer disease,3016,Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.,"Is the triple ""Folic Acid related to Alzheimer disease"" supported by the sentence: ""Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study.""?",False, +7868306,Folic Acid related to coronary artery disorder,3017,"In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.","Is the triple ""Folic Acid related to coronary artery disorder"" supported by the sentence: ""In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.""?",False, +7765942,Folic Acid related to anemia,3018,"No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.","Is the triple ""Folic Acid related to anemia"" supported by the sentence: ""No nutrient deficiencies were found in 48.1% of cases with anemia, while iron deficiency anemia was present in 39% of the population studied, and folate and or vitamin B12 deficiency were associated with anemia in only 12.9% of cases.""?",False, +7303518,Folic Acid related to epilepsy,3019,"Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.","Is the triple ""Folic Acid related to epilepsy"" supported by the sentence: ""Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.""?",False, +7234301,Folic Acid related to Reduced blood folate concentration,3020,Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.,"Is the triple ""Folic Acid related to Reduced blood folate concentration"" supported by the sentence: ""Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells.""?",False, +7229825,Folic Acid related to iron deficiency anemia,3021,Status of labile folate in iron deficiency anaemia.,"Is the triple ""Folic Acid related to iron deficiency anemia"" supported by the sentence: ""Status of labile folate in iron deficiency anaemia.""?",False, +7175279,Folic Acid related to rheumatoid arthritis,3022,[Methotrexate and folates in rheumatoid arthritis].,"Is the triple ""Folic Acid related to rheumatoid arthritis"" supported by the sentence: ""[Methotrexate and folates in rheumatoid arthritis].""?",False, +25522909,Folic Acid causes diabetic kidney disease,3023,"The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.","Is the triple ""Folic Acid causes diabetic kidney disease"" supported by the sentence: ""The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron.""?",False, +18689556,Folic Acid causes Alzheimer disease,3024,Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.,"Is the triple ""Folic Acid causes Alzheimer disease"" supported by the sentence: ""Functional network analysis of folic acid-induced DMGs in these AD models revealed subnetworks composed of 24 focus genes in the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway and 12 focus genes in the long-term depression (LTD) signaling pathway.""?",False, +17559847,Folic Acid causes iron deficiency anemia,3025,"With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).","Is the triple ""Folic Acid causes iron deficiency anemia"" supported by the sentence: ""With logistic regression analysis, it was observed that the relation between NH and ID/IDA is due to concomitant low normal folate levels (p-value = 0.044).""?",False, +17044072,Folic Acid causes depressive disorder,3026,The low blood level of folates is the primary cause of depression in Alzheimer's disease.,"Is the triple ""Folic Acid causes depressive disorder"" supported by the sentence: ""The low blood level of folates is the primary cause of depression in Alzheimer's disease.""?",False, +15826434,Folic Acid causes male infertility,3027,This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.,"Is the triple ""Folic Acid causes male infertility"" supported by the sentence: ""This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility.""?",False, +15057448,Folic Acid causes chronic kidney disease,3028,"The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.","Is the triple ""Folic Acid causes chronic kidney disease"" supported by the sentence: ""The level of both antibodies correlated with tHcy (r = 0.56, P <0.0001 and r = 0.67, P <0.0001, respectively), 8-iso-PGF(2alpha) (r = 0.48, P <0.0001 and r = 0.63, P <0.0001, respectively), and folate (r = -0.18, P = 0.0054 and r = -0.38, P <0.0001, respectively), but not with HD duration, the initial cause of ESRD, and CV comorbidity.""?",False, +14954987,Folic Acid causes autism spectrum disorder,3029,"Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.","Is the triple ""Folic Acid causes autism spectrum disorder"" supported by the sentence: ""Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.""?",False, +13825749,Folic Acid causes cleft lip,3030,The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).,"Is the triple ""Folic Acid causes cleft lip"" supported by the sentence: ""The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).""?",False, +13656973,Folic Acid causes neoplasm,3031,Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.,"Is the triple ""Folic Acid causes neoplasm"" supported by the sentence: ""Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.""?",False, +12212539,Folic Acid causes lymphoma,3032,"Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.","Is the triple ""Folic Acid causes lymphoma"" supported by the sentence: ""Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma.""?",False, +11472417,Folic Acid causes gingival overgrowth,3033,Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.,"Is the triple ""Folic Acid causes gingival overgrowth"" supported by the sentence: ""Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.""?",False, +11073752,Folic Acid causes myocardial ischemia,3034,[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].,"Is the triple ""Folic Acid causes myocardial ischemia"" supported by the sentence: ""[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].""?",False, +10016854,Folic Acid causes hypertensive disorder,3035,"In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.","Is the triple ""Folic Acid causes hypertensive disorder"" supported by the sentence: ""In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons.""?",False, +8671948,Folic Acid causes cleft palate,3036,"These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.","Is the triple ""Folic Acid causes cleft palate"" supported by the sentence: ""These results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.""?",False, +8640403,Folic Acid causes epilepsy,3037,Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.,"Is the triple ""Folic Acid causes epilepsy"" supported by the sentence: ""Information is lacking as to whether folate might induce seizures in certain ostensibly normal individuals.""?",False, +7900734,Folic Acid causes coronary artery disorder,3038,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes coronary artery disorder"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, +7900729,Folic Acid causes atherosclerosis,3039,"Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.","Is the triple ""Folic Acid causes atherosclerosis"" supported by the sentence: ""Recently, it has been found that reduced serum levels of folic acid, vitamin B12, and vitamin B6 are related to the etiology of atherosclerosis and coronary heart disease.""?",False, +7637475,Folic Acid causes Reduced blood folate concentration,3040,"The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.","Is the triple ""Folic Acid causes Reduced blood folate concentration"" supported by the sentence: ""The hypothesis is advanced here that photolysis of folate by ultraviolet (UV) light may, in some women, precipitate a folate deficiency sufficient to cause a neural tube defect (NTD) during the first few weeks of pregnancy.""?",False, +7460069,Folic Acid causes anemia,3041,"If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.","Is the triple ""Folic Acid causes anemia"" supported by the sentence: ""If it was less than 11 g/dl, blood was taken for serum iron, ferritin, transferrin, red cell zinc protoporphyrin, serum folate, vitamin B12 and thalassemia screen to establish cause of anaemia.""?",False, +7392389,Folic Acid causes neural tube defect,3042,The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.,"Is the triple ""Folic Acid causes neural tube defect"" supported by the sentence: ""The involvement of folic acid in the aetiology of neural tube defects (NTDs) has been discussed for decades.""?",False, +27400709,Folic Acid affects coronary artery disorder,3043,"Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.","Is the triple ""Folic Acid affects coronary artery disorder"" supported by the sentence: ""Clinical trials are needed to assess expeditiously the effect of antioxidants, particularly vitamin E, and of folic acid on CAD and atherosclerosis.""?",False, +27350602,Folic Acid affects cleft palate,3044,"Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""Both methanol and low dietary folic acid increased the incidence of cleft palate, with the highest number of affected litters in the low dietary folic acid group.""?",False, +26684582,Folic Acid affects colorectal neoplasm,3045,The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.,"Is the triple ""Folic Acid affects colorectal neoplasm"" supported by the sentence: ""The suppression of hyperproliferative activity by supplemental folic acid may contribute to the protective effect of folic acid in colorectal neoplasia.""?",False, +26504524,Folic Acid affects neoplasm,3046,"In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""In contrast to bolus treatment, the increase in (6R)-5,10-methylenetetrahydrofolate in the marrow and small intestine with both leucovorin and folic acid infusion was similar to the increase in the tumor.""?",False, +26433324,Folic Acid affects psychotic disorder,3047,Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.,"Is the triple ""Folic Acid affects psychotic disorder"" supported by the sentence: ""Others have described a folate-responsive psychosis which was associated with markedly reduced methylene reductase activity.""?",False, +25046427,Folic Acid affects malaria,3048,Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.,"Is the triple ""Folic Acid affects malaria"" supported by the sentence: ""Evaluating folic acid dosage levels used in supplementation efforts may increase public health understanding of its potential impacts on malaria risk and severity and on treatment failures.""?",False, +24121807,Folic Acid affects osteoporosis,3049,"However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.","Is the triple ""Folic Acid affects osteoporosis"" supported by the sentence: ""However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood.""?",False, +23769753,Folic Acid affects anemia,3050,Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.,"Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""Low serum folate concentrations in dogs with non-associative immune-mediated haemolytic anaemia.""?",False, +22602503,Folic Acid affects gingival overgrowth,3051,The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.,"Is the triple ""Folic Acid affects gingival overgrowth"" supported by the sentence: ""The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man.""?",False, +21177262,Folic Acid affects autism spectrum disorder,3052,The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.,"Is the triple ""Folic Acid affects autism spectrum disorder"" supported by the sentence: ""The aim of this study was to examine the effects of folic acid (FA) on the autistic phenotypes in BTBR T+ Itpr3tf/J (BTBR) mice and to investigate underlying mechanisms.""?",False, +20060781,Folic Acid affects Hemorrhage,3053,"Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.","Is the triple ""Folic Acid affects Hemorrhage"" supported by the sentence: ""Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations.""?",False, +19336710,Folic Acid affects polycystic ovary syndrome,3054,"Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).","Is the triple ""Folic Acid affects polycystic ovary syndrome"" supported by the sentence: ""Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC).""?",False, +19172236,Folic Acid affects chronic kidney disease,3055,"Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.","Is the triple ""Folic Acid affects chronic kidney disease"" supported by the sentence: ""Conclusions and Relevance: Enalapril-folic acid therapy, compared with enalapril alone, can significantly delay the progression of CKD among patients with mild-to-moderate CKD.""?",False, +19066599,Folic Acid affects Alzheimer disease,3056,"Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""Both phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD itself is unclear.""?",False, +15798837,Folic Acid affects hypertensive disorder,3057,"BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.","Is the triple ""Folic Acid affects hypertensive disorder"" supported by the sentence: ""BACKGROUND: An elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid.""?",False, +15143772,Folic Acid affects Reduced blood folate concentration,3058,"However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""However, contrary to the hypothesis, the uptake of 3H-folate by feto-placental tissues was increased in folate deficiency and by ethanol treatment, indicating that folate transfer was not impaired by the ethanol treatment.""?",False, +14869410,Folic Acid affects epilepsy,3059,It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.,"Is the triple ""Folic Acid affects epilepsy"" supported by the sentence: ""It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.""?",False, +14664528,Folic Acid affects depressive disorder,3060,Our findings that poor folate status may increase depression needs to be further investigated.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Our findings that poor folate status may increase depression needs to be further investigated.""?",False, +14002988,Folic Acid affects depressive disorder,3061,We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.,"Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""We investigated whether intake of prenatal multivitamins containing folic acid (MVandFA) was associated with decreased rates of depression among pregnant women.""?",False, +13092563,Folic Acid affects depressive disorder,3062,"Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.","Is the triple ""Folic Acid affects depressive disorder"" supported by the sentence: ""Zinc, folic acid, selenium, chromium and omega-3 fatty acids are all examples of nutrients which have been shown to influence depression, anger and/or anxiety.""?",False, +12773835,Folic Acid affects atherosclerosis,3063,"This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.","Is the triple ""Folic Acid affects atherosclerosis"" supported by the sentence: ""This stratified randomized controlled trial was designed to measure the effect of high dose oral vitamin B6, vitamin B12, and folic acid on homocysteine levels, and to evaluate the effect on atherosclerosis as measured by Intima-Media Thickness (IMT) of carotid arteries.""?",False, +11897009,Folic Acid affects Alzheimer disease,3064,"As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.","Is the triple ""Folic Acid affects Alzheimer disease"" supported by the sentence: ""As recent findings suggest, the perturbance of homocysteine/folate or one-carbon metabolism can adversely affect both the developing and the adult brain, and increase the risk of neural tube defects and Alzheimer's disease.""?",False, +10798682,Folic Acid affects type 2 diabetes mellitus,3065,"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.","Is the triple ""Folic Acid affects type 2 diabetes mellitus"" supported by the sentence: ""Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.""?",False, +10733114,Folic Acid affects Reduced blood folate concentration,3066,"Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.","Is the triple ""Folic Acid affects Reduced blood folate concentration"" supported by the sentence: ""Conversely, it is also known that folate is necessary for cancer growth, but few experiments in laboratory animals have evaluated the effects of folate deficiency on the development of chemically induced cancers.""?",False, +10375553,Folic Acid affects neoplasm,3067,"When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.","Is the triple ""Folic Acid affects neoplasm"" supported by the sentence: ""When the mixed micelles were conjugated with folic acid, the in vitro results demonstrated that the micelles were more effective in tumor cell kill due to accelerated drug release and folate receptor-mediated tumor uptake.""?",False, +10355008,Folic Acid affects anemia,3068,"The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.","Is the triple ""Folic Acid affects anemia"" supported by the sentence: ""The TfR level was related with a disease stage and activity of the prolipherative process in cases of autoimmune hemolytic anemia, B12-folate-dependent anemia, lympho- and myeloprolipherative diseases and in oncology patients.""?",False, +8962241,Folic Acid affects cleft palate,3069,"OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.","Is the triple ""Folic Acid affects cleft palate"" supported by the sentence: ""OBJECTIVE: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals.""?",False, +8101952,Folic Acid affects neural tube defect,3070,"CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""CONCLUSION: Recommendations of The Expert Advisory Group on Folic Acid in prevention of neural tube defects has several aspects (1) reducing the risk of the first NTD occurrence by preconceptional vitamin supplementation of folic acid in the dose of 0.4 mg day, which would go on until the end of the 12th week (2) reducing the risk of NTD recurrence in offspring of men and women with spina-bifida or with obstetric history affected with NTD by preconceptional vitamin supplementation of folic acid in the dose of 4 mg daily during the first 12 weeks and (3) organizing educational programmes for medical staff as well as the whole population in order to popularize vitamin supplementation.""?",False, +7127212,Folic Acid affects neural tube defect,3071,"To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.","Is the triple ""Folic Acid affects neural tube defect"" supported by the sentence: ""To eliminate iron deficiency and folic-acid-dependent neural tube defects (FADNTDs) in low-income populations, a new set of approaches will have to be developed.""?",False, +19290979,Folic Acid produces neoplasm,3072,"Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.","Is the triple ""Folic Acid produces neoplasm"" supported by the sentence: ""Our works demonstrated that K237/FA-PEG-PLGA nanoparticles have great potential as biodegradable drug carriers, especially for tumors expressing the folate and KDr receptor.""?",False, +26301481,Folic Acid disrupts epilepsy,3073,A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.,"Is the triple ""Folic Acid disrupts epilepsy"" supported by the sentence: ""A decrease in the content of folic acid to the lower limit of normal was followed by a reduced incidence of epileptic fits.""?",False, +22602502,Folic Acid disrupts gingival overgrowth,3074,"Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.","Is the triple ""Folic Acid disrupts gingival overgrowth"" supported by the sentence: ""Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.""?",False, +21452213,Folic Acid disrupts cleft palate,3075,"Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).","Is the triple ""Folic Acid disrupts cleft palate"" supported by the sentence: ""Higher levels of dietary folate were found to be associated with a reduced risk for all clefts (adjusted OR: 0.98, 95% CI, 0.96-0.99), CL/P (adjusted OR: 0.98, 95% CI, 0.96-0.99), and CP (adjusted OR: 0.96, 95% CI, 0.93-0.99).""?",False, +20711939,Folic Acid disrupts autism spectrum disorder,3076,Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.,"Is the triple ""Folic Acid disrupts autism spectrum disorder"" supported by the sentence: ""Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.""?",False, +20091947,Folic Acid disrupts atherosclerosis,3077,"Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.","Is the triple ""Folic Acid disrupts atherosclerosis"" supported by the sentence: ""Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.""?",False, +18758283,Folic Acid disrupts malaria,3078,"Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.","Is the triple ""Folic Acid disrupts malaria"" supported by the sentence: ""Furthermore, supraphysiological, and possibly even physiological, folic acid dosages may favour Plasmodium falciparum growth, inhibit parasite clearance of sulphadoxine-pyrimethamine (SP)-treated malaria and increase subsequent recrudescence.""?",False, +18711179,Folic Acid disrupts hypertensive disorder,3079,"Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.","Is the triple ""Folic Acid disrupts hypertensive disorder"" supported by the sentence: ""Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.""?",False, +16597425,Folic Acid disrupts neoplasm,3080,"Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.","Is the triple ""Folic Acid disrupts neoplasm"" supported by the sentence: ""Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture.""?",False, +13887579,Folic Acid disrupts anemia,3081,Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.,"Is the triple ""Folic Acid disrupts anemia"" supported by the sentence: ""Recent evidence of reduction in anemia can be attributed to flour supplementation with iron and folic acid.""?",False, +13415357,Folic Acid disrupts cleft lip,3082,[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].,"Is the triple ""Folic Acid disrupts cleft lip"" supported by the sentence: ""[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?].""?",False, +12569851,Folic Acid disrupts HIV infectious disease,3083,"Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.","Is the triple ""Folic Acid disrupts HIV infectious disease"" supported by the sentence: ""Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease and notwithstanding gastro-intestinal complaints, pathogen-negative diarrhoea or drug treatment.""?",False, +11807458,Folic Acid disrupts colorectal neoplasm,3084,Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.,"Is the triple ""Folic Acid disrupts colorectal neoplasm"" supported by the sentence: ""Currently there are only few human intervention trials which show that folic acid can modify and inhibit the development of colorectal tumors.""?",False, +10170875,Folic Acid disrupts depressive disorder,3085,The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.,"Is the triple ""Folic Acid disrupts depressive disorder"" supported by the sentence: ""The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.""?",False, +8333532,Folic Acid disrupts neural tube defect,3086,"Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.","Is the triple ""Folic Acid disrupts neural tube defect"" supported by the sentence: ""Use of folic acid supplements before conception and during the first trimester of pregnancy, is associated with a reduced incidence of neural tube defects.""?",False, +8088152,Folic Acid disrupts Reduced blood folate concentration,3087,"We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.","Is the triple ""Folic Acid disrupts Reduced blood folate concentration"" supported by the sentence: ""We conclude that alcohol administration for 2 weeks leads to local folate deficiency of colonic mucosa in rats, most probably via the degradation of folate by the high levels of acetaldehyde microbially produced from ethanol.""?",False, +7255352,Folic Acid disrupts coronary artery disorder,3088,Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.,"Is the triple ""Folic Acid disrupts coronary artery disorder"" supported by the sentence: ""Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.""?",False, +24827653,Folic Acid prevents Hemorrhage,3089,"Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.","Is the triple ""Folic Acid prevents Hemorrhage"" supported by the sentence: ""Interestingly, folic acid reduced hypertension and hemorrhage in hSSAO TG mice fed with high-fat diets.""?",False, +19249670,Folic Acid prevents epilepsy,3090,"The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.","Is the triple ""Folic Acid prevents epilepsy"" supported by the sentence: ""The supplementation of folate and vitamin B12 may be beneficial for the prevention of epilepsy with secondary thrombosis, making it valuable in application.""?",False, +18676969,Folic Acid prevents neoplasm,3091,"Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.","Is the triple ""Folic Acid prevents neoplasm"" supported by the sentence: ""Moreover, tumor targeting ligands such as folate increased cancer-cell targeting of the exosomes resulting in enhanced tumor reduction.""?",False, +17577921,Folic Acid prevents diabetic kidney disease,3092,Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.,"Is the triple ""Folic Acid prevents diabetic kidney disease"" supported by the sentence: ""Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.""?",False, +16233198,Folic Acid prevents iron deficiency anemia,3093,"UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.","Is the triple ""Folic Acid prevents iron deficiency anemia"" supported by the sentence: ""UNLABELLED: Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women.""?",False, +15458838,Folic Acid prevents myocardial ischemia,3094,"Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.","Is the triple ""Folic Acid prevents myocardial ischemia"" supported by the sentence: ""Hormone replacement therapy, antioxidants, folic acid, and aspirin in healthy women under 65 years of age have recently been shown to be ineffective in the prevention of IHD.""?",False, +15385859,Folic Acid prevents depressive disorder,3095,These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.,"Is the triple ""Folic Acid prevents depressive disorder"" supported by the sentence: ""These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health.""?",False, +13602735,Folic Acid prevents gingival overgrowth,3096,A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.,"Is the triple ""Folic Acid prevents gingival overgrowth"" supported by the sentence: ""A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.""?",False, +12999215,Folic Acid prevents hypertensive disorder,3097,"Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.","Is the triple ""Folic Acid prevents hypertensive disorder"" supported by the sentence: ""Folic acid, but not BH(4), prevented the development of hypertension caused by ACTH and Dex treatment.""?",False, +12947495,Folic Acid prevents cleft lip,3098,CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.,"Is the triple ""Folic Acid prevents cleft lip"" supported by the sentence: ""CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third.""?",False, +12911127,Folic Acid prevents Alzheimer disease,3099,BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.,"Is the triple ""Folic Acid prevents Alzheimer disease"" supported by the sentence: ""BACKGROUND: Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels.""?",False, +11842763,Folic Acid prevents cervical polyp,3100,"Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.","Is the triple ""Folic Acid prevents cervical polyp"" supported by the sentence: ""Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin.""?",False, +10283354,Folic Acid prevents heart disorder,3101,"Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?","Is the triple ""Folic Acid prevents heart disorder"" supported by the sentence: ""Do folic acid, vitamin B6, and vitamin B12 protect against heart disease?""?",False, +10242010,Folic Acid prevents cleft palate,3102,"CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.","Is the triple ""Folic Acid prevents cleft palate"" supported by the sentence: ""CONCLUSIONS: Although FA and ME, at appropriate levels, can reduce individually the frequency of RA-induced cleft palate and other defects in mice, the results from the present study suggest that there is an additive interaction between the two therapeutic agents that can reduce further the teratogenic impact of RA.""?",False, +9547944,Folic Acid prevents atherosclerosis,3103,CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.,"Is the triple ""Folic Acid prevents atherosclerosis"" supported by the sentence: ""CONCLUSIONS: These results demonstrate that long-term folic acid improves arterial endothelial function and has potential implications for the prevention of atherosclerosis in adults with hyperhomocysteinemia.""?",False, +9000016,Folic Acid prevents anemia,3104,OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.,"Is the triple ""Folic Acid prevents anemia"" supported by the sentence: ""OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant.""?",False, +8746975,Folic Acid prevents Reduced blood folate concentration,3105,The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.,"Is the triple ""Folic Acid prevents Reduced blood folate concentration"" supported by the sentence: ""The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.""?",False, +8675157,Folic Acid prevents coronary artery disorder,3106,"Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.","Is the triple ""Folic Acid prevents coronary artery disorder"" supported by the sentence: ""Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended.""?",False, +8467407,Folic Acid prevents myocardial infarction,3107,"Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.","Is the triple ""Folic Acid prevents myocardial infarction"" supported by the sentence: ""Thus, the available evidence is insufficient to recommend the routine use of vitamin E, vitamin C or folate supplements for the prevention of myocardial infarction or stroke.""?",False, +7303516,Folic Acid prevents neural tube defect,3108,She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.,"Is the triple ""Folic Acid prevents neural tube defect"" supported by the sentence: ""She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects.""?",False, +23795062,Folic Acid predisposes depressive disorder,3109,A low level of folate is also thought to be a risk for depression in adults.,"Is the triple ""Folic Acid predisposes depressive disorder"" supported by the sentence: ""A low level of folate is also thought to be a risk for depression in adults.""?",False, +20875914,Folic Acid predisposes chronic kidney disease,3110,"The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.","Is the triple ""Folic Acid predisposes chronic kidney disease"" supported by the sentence: ""The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.""?",False, +20436878,Folic Acid predisposes psychotic disorder,3111,"Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.","Is the triple ""Folic Acid predisposes psychotic disorder"" supported by the sentence: ""Conclusions and Relevance: The results of this study suggest an association between gestational exposure to fortification of grain products with folic acid and altered cortical development and, in turn, with reduction in the risk of psychosis in youths.""?",False, +19071958,Folic Acid predisposes type 1 diabetes mellitus,3112,"The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.","Is the triple ""Folic Acid predisposes type 1 diabetes mellitus"" supported by the sentence: ""The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study.""?",False, +18723777,Folic Acid predisposes systemic lupus erythematosus,3113,"CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.","Is the triple ""Folic Acid predisposes systemic lupus erythematosus"" supported by the sentence: ""CONCLUSION: The current study highlighted the importance of genetic polymorphisms in folate, xenobiotic, TLR, and STAT4 signaling pathways as moderate predictors of SLE risk and delineates the molecular pathophysiology associated with these single nucleotide polymorphisms (SNPs) by demonstrating their association with specific auto-antibody production.""?",False, +16571781,Folic Acid predisposes habitual spontaneous abortion,3114,"Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.","Is the triple ""Folic Acid predisposes habitual spontaneous abortion"" supported by the sentence: ""Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.""?",False, +16186991,Folic Acid predisposes Reduced blood folate concentration,3115,"This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.","Is the triple ""Folic Acid predisposes Reduced blood folate concentration"" supported by the sentence: ""This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.""?",False, +15780148,Folic Acid predisposes epilepsy,3116,Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.,"Is the triple ""Folic Acid predisposes epilepsy"" supported by the sentence: ""Further exploration of baseline homocysteine and folate levels as predictors of seizure risk following traumatic brain injury is warranted.""?",False, +15351663,Folic Acid predisposes breast neoplasm,3117,Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.,"Is the triple ""Folic Acid predisposes breast neoplasm"" supported by the sentence: ""Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring.""?",False, +14681570,Folic Acid predisposes malaria,3118,"Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.","Is the triple ""Folic Acid predisposes malaria"" supported by the sentence: ""Nonetheless, while nearly all of the women in this study were prescribed anti-folates, the overall risk of placental malaria and LBW was unacceptably high.""?",False, +13204073,Folic Acid predisposes autism spectrum disorder,3119,"Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.","Is the triple ""Folic Acid predisposes autism spectrum disorder"" supported by the sentence: ""Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.""?",False, +12966788,Folic Acid predisposes cleft palate,3120,"In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.","Is the triple ""Folic Acid predisposes cleft palate"" supported by the sentence: ""In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B-6 status, assessed by both PLP and EAST-AC values, compared to those with adequate status by both values.""?",False, +12851634,Folic Acid predisposes osteoporosis,3121,"We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.","Is the triple ""Folic Acid predisposes osteoporosis"" supported by the sentence: ""We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect.""?",False, +12628867,Folic Acid predisposes neoplasm,3122,"In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.","Is the triple ""Folic Acid predisposes neoplasm"" supported by the sentence: ""In addition to masking vitamin-B12 deficiency, there is some evidence that folic acid may promote progression of established tumours in laboratory animals and humans.""?",False, +11373442,Folic Acid predisposes colorectal neoplasm,3123,Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.,"Is the triple ""Folic Acid predisposes colorectal neoplasm"" supported by the sentence: ""Interactions between high alcohol-low folate and the MTHFR677TT genotype with risk of colorectal neoplasia suggest that alcohol is acting through its effects on one-carbon metabolism because the combination of high alcohol-low folate and the MTHFR677TT genotype are related to markedly elevated serum levels of homocysteine and to DNA hypomethylation.""?",False, +11241979,Folic Acid predisposes hypertensive disorder,3124,"CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.","Is the triple ""Folic Acid predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSION: Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension.""?",False, +9419598,Folic Acid predisposes Alzheimer disease,3125,"Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.","Is the triple ""Folic Acid predisposes Alzheimer disease"" supported by the sentence: ""Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown.""?",False, +9024956,Folic Acid predisposes non-small cell lung carcinoma,3126,CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.,"Is the triple ""Folic Acid predisposes non-small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: This case control study does not support the hypothesis that low folate is an independent risk factor for NSCLC.""?",False, +8876702,Folic Acid predisposes atherosclerosis,3127,"The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.","Is the triple ""Folic Acid predisposes atherosclerosis"" supported by the sentence: ""The studied group had classic risk factors of atherosclerosis but did not differ in fasting plasma homocysteine, folic acid, and vitamin B12 levels in either the control group or population sample.""?",False, +8590186,Folic Acid predisposes anemia,3128,"Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.","Is the triple ""Folic Acid predisposes anemia"" supported by the sentence: ""Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression.""?",False, +8210149,Folic Acid predisposes myocardial ischemia,3129,Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.,"Is the triple ""Folic Acid predisposes myocardial ischemia"" supported by the sentence: ""Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.""?",False, +8202566,Folic Acid predisposes coronary artery disorder,3130,"Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.","Is the triple ""Folic Acid predisposes coronary artery disorder"" supported by the sentence: ""Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.""?",False, +7807562,Folic Acid predisposes myocardial infarction,3131,The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.,"Is the triple ""Folic Acid predisposes myocardial infarction"" supported by the sentence: ""The risk of MI in smokers may at least partly be attributed to hyperhomocysteinemia or low folate.""?",False, +7720012,Phenylbutazone subclass of Oxyphenbutazone,3132,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Phenylbutazone subclass of Oxyphenbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, +26246718,Phenylbutazone related to Oxyphenbutazone,3133,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, +25613560,Phenylbutazone related to Oxyphenbutazone,3134,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Phenylbutazone related to Oxyphenbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, +20340997,Phenylbutazone physically interacts with Oxyphenbutazone,3135,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Phenylbutazone physically interacts with Oxyphenbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, +26417219,"Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",3136,"At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.","Is the triple ""Phenylbutazone physically interacts with 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine"" supported by the sentence: ""At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured.""?",False, +17467114,Phenylbutazone affects rheumatic disorder,3137,[Research on the mechanism of action of phenylbutazone in rheumatic diseases].,"Is the triple ""Phenylbutazone affects rheumatic disorder"" supported by the sentence: ""[Research on the mechanism of action of phenylbutazone in rheumatic diseases].""?",False, +8146434,Phenylbutazone affects Oxyphenbutazone,3138,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Phenylbutazone affects Oxyphenbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, +7720012,Oxyphenbutazone subclass of Phenylbutazone,3139,"Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).","Is the triple ""Oxyphenbutazone subclass of Phenylbutazone"" supported by the sentence: ""Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h).""?",False, +25613560,Oxyphenbutazone related to Phenylbutazone,3140,"Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""Mean concentrations of oxyphenbutazone in all fluids were lower than phenylbutazone concentrations at all times, but ready penetration of the metabolite into body fluids, especially into inflammatory exudate, occurred suggesting that oxyphenbutazone may contribute to the anti-inflammatory effect.""?",False, +26246718,Oxyphenbutazone related to Phenylbutazone,3141,"The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.","Is the triple ""Oxyphenbutazone related to Phenylbutazone"" supported by the sentence: ""The circadian variations in paw-edema produced by carrageenin and the anti-inflammatory effect of phenylbutazone were studied, in rats kept under a 12 light-12 dark regimen, in comparison with the variations of plasma phenylbutazone and oxyphenbutazone levels.""?",False, +20340997,Oxyphenbutazone physically interacts with Phenylbutazone,3142,There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.,"Is the triple ""Oxyphenbutazone physically interacts with Phenylbutazone"" supported by the sentence: ""There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.""?",False, +8146434,Oxyphenbutazone affects Phenylbutazone,3143,"The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.","Is the triple ""Oxyphenbutazone affects Phenylbutazone"" supported by the sentence: ""The selectivity (inter-assay C.V.<4%), sensitivity (limits of quantitation of 0.25 microg/ml for HYD, DEX and IND, 0.5 microg/ml for PB and 1 microg/ml for OPB, despite the occurrence of significant degradation of OPB and PB during the analysis) and precision (intra-assay and inter-assay C.V.'s of about 3-6 and 9-15%, respectively) of the method appeared appropriate for anti-doping control of racehorses.""?",False, +19336632,Etofenamate prevents Arthralgia,3144,The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.,"Is the triple ""Etofenamate prevents Arthralgia"" supported by the sentence: ""The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis.""?",False, +11418550,Piroxicam subclass of 5'-Hydroxypiroxicam,3145,"The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.","Is the triple ""Piroxicam subclass of 5'-Hydroxypiroxicam"" supported by the sentence: ""The major component detected in urine after the administration of piroxicam was 5'-hydroxypiroxicam, which was detectable up to 24 h post-administration.""?",False, +27695181,Piroxicam affects osteoarthritis,3146,Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.,"Is the triple ""Piroxicam affects osteoarthritis"" supported by the sentence: ""Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam.""?",False, +24435495,Piroxicam affects Pain,3147,The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.,"Is the triple ""Piroxicam affects Pain"" supported by the sentence: ""The effect of a novel nonsteroidal antiinflammatory drug Rengasil on pain at rest in rheumatoid arthritis and arthroses was studied in comparison with piroxicam and placebo.""?",False, +18791248,Piroxicam disrupts Pain,3148,Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.,"Is the triple ""Piroxicam disrupts Pain"" supported by the sentence: ""Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders.""?",False, +13746683,Piroxicam prevents Myalgia,3149,"We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.","Is the triple ""Piroxicam prevents Myalgia"" supported by the sentence: ""We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.""?",False, +13092622,Piroxicam prevents Pain,3150,"CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.","Is the triple ""Piroxicam prevents Pain"" supported by the sentence: ""CONCLUSIONS: Diacerein was as effective as piroxicam in reducing pain and improving function but, unlike piroxicam, displayed a carry-over effect and a better safety profile.""?",False, +9050885,Bufexamac related to rheumatic disorder,3151,[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].,"Is the triple ""Bufexamac related to rheumatic disorder"" supported by the sentence: ""[Double-blind comparative study of bufexamac and triamcinolone acetonide given by local injection in abarticular rheumatism or osteoarthritis].""?",False, +27600921,Mometasone furoate related to psoriasis,3152,[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].,"Is the triple ""Mometasone furoate related to psoriasis"" supported by the sentence: ""[Mometasone and calcipotriol optimize the initial therapeutic effect of dithranol in chronic persistent psoriasis].""?",False, +26936147,Mometasone furoate related to skin disorder,3153,Mometasone versus betamethasone creams: a trial in dermatoses.,"Is the triple ""Mometasone furoate related to skin disorder"" supported by the sentence: ""Mometasone versus betamethasone creams: a trial in dermatoses.""?",False, +20328277,Mometasone furoate related to obstructive sleep apnea syndrome,3154,"Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.","Is the triple ""Mometasone furoate related to obstructive sleep apnea syndrome"" supported by the sentence: ""Comparison of the Efficacy, Side Effects, and Cost of Modafinil and Intranasal Mometasone Furoate in Obstructive Sleep Apnea-Hypopnea Syndrome: A Preliminary Clinical Study.""?",False, +20031657,Mometasone furoate related to diffuse alopecia areata,3155,Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.,"Is the triple ""Mometasone furoate related to diffuse alopecia areata"" supported by the sentence: ""Study revealed the efficacy and safety of adapalene and mometasone furoate combination in AA.""?",False, +18451558,Mometasone furoate related to spinal cord injury,3156,The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).,"Is the triple ""Mometasone furoate related to spinal cord injury"" supported by the sentence: ""The aim of the present study was to compare the efficacy of MPSS in respect to other GCs such as dexamethasone (Dex) and mometasone furoate (MF) in an in vitro suitable model of LPS-induced inflammation in J774 cells as well as in an in vivo experimental mouse SCI (compression model).""?",False, +15193244,Mometasone furoate related to severe acute respiratory syndrome,3157,CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.,"Is the triple ""Mometasone furoate related to severe acute respiratory syndrome"" supported by the sentence: ""CONCLUSION: The use of MF in SAR is associated with reduced eosinophilic inflammation in the olfactory region and improved symptoms of AR.""?",False, +12129006,Mometasone furoate related to asthma,3158,Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.,"Is the triple ""Mometasone furoate related to asthma"" supported by the sentence: ""Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma.""?",False, +12122099,Mometasone furoate related to allergic rhinitis,3159,"The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.","Is the triple ""Mometasone furoate related to allergic rhinitis"" supported by the sentence: ""The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.""?",False, +11696210,Mometasone furoate related to chronic obstructive pulmonary disease,3160,Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.,"Is the triple ""Mometasone furoate related to chronic obstructive pulmonary disease"" supported by the sentence: ""Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.""?",False, +10078337,Mometasone furoate related to perennial allergic rhinitis,3161,Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.,"Is the triple ""Mometasone furoate related to perennial allergic rhinitis"" supported by the sentence: ""Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis.""?",False, +8366912,Mometasone furoate related to seasonal allergic rhinitis,3162,[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].,"Is the triple ""Mometasone furoate related to seasonal allergic rhinitis"" supported by the sentence: ""[Effectiveness and tolerability of the glucocorticoid mometasone furoate given as nasal spray in seasonal allergic rhinitis].""?",False, +15620377,Mometasone furoate affects asthma,3163,"Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).","Is the triple ""Mometasone furoate affects asthma"" supported by the sentence: ""Inhaled montelukast plus inhaled mometasone was also significantly more effective than placebo plus inhaled mometasone in improving daytime asthma symptom scores (p = .005) and nighttime asthma symptom scores (p = .015), increasing the percentage of days with asthma control (p = .004), decreasing the percentage of days with asthma exacerbations (p <= .001), and decreasing the blood eosinophil count (p = .013).""?",False, +14474022,Mometasone furoate affects Nasal congestion,3164,CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.,"Is the triple ""Mometasone furoate affects Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.""?",False, +8375063,Mometasone furoate affects allergic rhinitis,3165,The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.,"Is the triple ""Mometasone furoate affects allergic rhinitis"" supported by the sentence: ""The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate.""?",False, +17026384,Mometasone furoate prevents Nasal congestion,3166,CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.,"Is the triple ""Mometasone furoate prevents Nasal congestion"" supported by the sentence: ""CONCLUSION: Mometasone furoate and azelastine which decrease nasal congestion and increase nasal volume are effective in the management of allergic rhinitis in children.""?",False, +15945486,Mometasone furoate prevents nasal cavity polyp,3167,Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.,"Is the triple ""Mometasone furoate prevents nasal cavity polyp"" supported by the sentence: ""Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps.""?",False, +10581126,Methimazole related to hyperthyroidism,3168,Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.,"Is the triple ""Methimazole related to hyperthyroidism"" supported by the sentence: ""Methimazole and carbimazole in hyperthyroidism: a comparison by a double blind technique.""?",False, +8213703,Methimazole causes hyperthyroidism,3169,"These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.","Is the triple ""Methimazole causes hyperthyroidism"" supported by the sentence: ""These results provide evidence that cats with hyperthyroidism have increased GFR compared to normal cats, and that treatment of feline hyperthyroidism with methimazole results in decreased GFR.""?",False, +10543639,Methimazole affects hyperthyroidism,3170,Exacerbation of hyperthyroidism by methimazole during iodide therapy.,"Is the triple ""Methimazole affects hyperthyroidism"" supported by the sentence: ""Exacerbation of hyperthyroidism by methimazole during iodide therapy.""?",False, +25010771,Methimazole prevents hyperthyroidism,3171,"Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.","Is the triple ""Methimazole prevents hyperthyroidism"" supported by the sentence: ""Conclusions: In Graves' hyperthyroid patients with no or nonsevere ophthalmopathy who have completed a standard course of methimazole therapy without an adverse effect and have achieved an euthyroid status that is stably maintained with low-dose methimazole, a long-term continuation of the low-dose methimazole of 2.5-5 mg daily is effective and safe in the prevention of recurrent hyperthyroidism or maintenance of euthyroid status as long as the low-dose methimazole is continued.""?",False, +24946616,Safinamide physically interacts with Monoamine Oxidase B,3172,"Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.","Is the triple ""Safinamide physically interacts with Monoamine Oxidase B"" supported by the sentence: ""Employing case studies of safinamide binding to MAO B, we demonstrate how to use AutoDock 4.2.6 and NAMD software packages.""?",False, +19231919,Safinamide affects Parkinson disease,3173,"The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.","Is the triple ""Safinamide affects Parkinson disease"" supported by the sentence: ""The future role of safinamide in PD may be that it enables a reduction in the dosage of dopamine replacement therapies, thereby reducing the adverse effects associated with these treatments.""?",False, +13464423,Safinamide affects Monoamine Oxidase B,3174,"A third agent with MAO-B inhibition properties, safinamide, is in phase III development.","Is the triple ""Safinamide affects Monoamine Oxidase B"" supported by the sentence: ""A third agent with MAO-B inhibition properties, safinamide, is in phase III development.""?",False, +25942595,Furosemide related to nephrotic syndrome,3175,[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].,"Is the triple ""Furosemide related to nephrotic syndrome"" supported by the sentence: ""[Polyuric affect of the association of dextran 40 and furosemide in diuretic-resistant nephrotic syndromes].""?",False, +25824332,Furosemide related to Fibrosis,3176,Spironolactone and frusemide in cirrhosis with ascites.,"Is the triple ""Furosemide related to Fibrosis"" supported by the sentence: ""Spironolactone and frusemide in cirrhosis with ascites.""?",False, +25791999,Furosemide related to cirrhosis of liver,3177,[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].,"Is the triple ""Furosemide related to cirrhosis of liver"" supported by the sentence: ""[The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis].""?",False, +25414865,Furosemide related to syndromic disease,3178,"In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.","Is the triple ""Furosemide related to syndromic disease"" supported by the sentence: ""In addition, therapy with caffeine, with theophylline, and with furosemide were moderately associated with the syndrome, although not significantly so.""?",False, +24461287,Furosemide related to essential hypertension,3179,Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.,"Is the triple ""Furosemide related to essential hypertension"" supported by the sentence: ""Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.""?",False, +22834232,Furosemide related to type 2 diabetes mellitus,3180,The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.,"Is the triple ""Furosemide related to type 2 diabetes mellitus"" supported by the sentence: ""The use of captopril and captopril plus frusemide as antihypertensive agents in non-insulin dependent diabetes.""?",False, +19148228,Furosemide related to hypertensive disorder,3181,"A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.","Is the triple ""Furosemide related to hypertensive disorder"" supported by the sentence: ""A study is presented of the state of central hemodynamics in comparison with hourly diuresis and plasma renin activity (PRA) in conditions of acute load tests with finoptin, digoxin and furosemide, at early stages of circulatory insufficiency in hypertensive disease.""?",False, +13031496,Furosemide related to acute kidney failure,3182,Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.,"Is the triple ""Furosemide related to acute kidney failure"" supported by the sentence: ""Dopamine and furosemide are therefore useful in mild acute renal failure in leptospirosis.""?",False, +8084093,Furosemide related to kidney failure,3183,"The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.","Is the triple ""Furosemide related to kidney failure"" supported by the sentence: ""The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in oliguric renal failure.""?",False, +27482853,Furosemide causes Edema,3184,In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.,"Is the triple ""Furosemide causes Edema"" supported by the sentence: ""In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation.""?",False, +27015887,Furosemide causes diabetes mellitus,3185,Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.,"Is the triple ""Furosemide causes diabetes mellitus"" supported by the sentence: ""Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.""?",False, +25990601,Furosemide causes hypertensive disorder,3186,[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].,"Is the triple ""Furosemide causes hypertensive disorder"" supported by the sentence: ""[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].""?",False, +25918508,Furosemide causes kidney disorder,3187,[Furosemide-induced nephropathy (author's transl)].,"Is the triple ""Furosemide causes kidney disorder"" supported by the sentence: ""[Furosemide-induced nephropathy (author's transl)].""?",False, +20167150,Furosemide causes syndromic disease,3188,"CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.","Is the triple ""Furosemide causes syndromic disease"" supported by the sentence: ""CONCLUSIONS We report a case of severe DRESS syndrome secondary to furosemide, only the second case report in medical literature implicating furosemide.""?",False, +19659078,Furosemide causes kidney failure,3189,"Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).","Is the triple ""Furosemide causes kidney failure"" supported by the sentence: ""Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome).""?",False, +11605290,Furosemide causes nephrotic syndrome,3190,"Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.","Is the triple ""Furosemide causes nephrotic syndrome"" supported by the sentence: ""Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance.""?",False, +9601857,Furosemide causes acute kidney failure,3191,"Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.","Is the triple ""Furosemide causes acute kidney failure"" supported by the sentence: ""Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure.""?",False, +8252635,Furosemide causes Dyspnea,3192,Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.,"Is the triple ""Furosemide causes Dyspnea"" supported by the sentence: ""Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea.""?",False, +26185017,Furosemide affects myocardial infarction,3193,Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.,"Is the triple ""Furosemide affects myocardial infarction"" supported by the sentence: ""Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and myocardial infarction.""?",False, +25909260,Furosemide affects nephrotic syndrome,3194,Plasma volume and effect of high dose frusemide in nephrotic syndrome.,"Is the triple ""Furosemide affects nephrotic syndrome"" supported by the sentence: ""Plasma volume and effect of high dose frusemide in nephrotic syndrome.""?",False, +22504977,Furosemide affects cirrhosis of liver,3195,"Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.","Is the triple ""Furosemide affects cirrhosis of liver"" supported by the sentence: ""Given that spironolactone or furosemide induces the aggravation of cirrhotic hyponatremia and dehydration, tolvaptan affects the management strategy of liver cirrhosis.""?",False, +17729926,Furosemide affects Edema,3196,"Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""Albumin and furosemide techniques may accelerate edema clearance, particularly when pulmonary capillary permeability is restored.""?",False, +16155102,Furosemide affects kidney disorder,3197,"This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.","Is the triple ""Furosemide affects kidney disorder"" supported by the sentence: ""This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.""?",False, +15732141,Furosemide affects hypertensive disorder,3198,As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.,"Is the triple ""Furosemide affects hypertensive disorder"" supported by the sentence: ""As frusemide failed to completely block the hypertension it is unlikely that the amiloride effect is due primarily to effects on urinary Na excretion.""?",False, +14935630,Furosemide affects kidney failure,3199,"In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.","Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""In the remaining 3, forced diuresis employing albumin plus furosemide in increasing doses to 600 mg/day reversed the renal failure independent of corticosteroid therapy.""?",False, +14887041,Furosemide affects acute kidney failure,3200,CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""CONCLUSIONS: Use of furosemide in combination with indomethacin increased the incidence of ARF but did not affect the PDA closure rate in preterm infants.""?",False, +14148250,Furosemide affects kidney failure,3201,OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.,"Is the triple ""Furosemide affects kidney failure"" supported by the sentence: ""OBJECTIVE: To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients.""?",False, +13740455,Furosemide affects Dyspnea,3202,"Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.","Is the triple ""Furosemide affects Dyspnea"" supported by the sentence: ""Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials.""?",False, +12836864,Furosemide affects Edema,3203,"BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.","Is the triple ""Furosemide affects Edema"" supported by the sentence: ""BACKGROUND: Furosemide and mannitol are used to reduce intracranial pressure, but the impact of furosemide on edema of injured brain is unclear.""?",False, +10718312,Furosemide affects diabetes mellitus,3204,[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].,"Is the triple ""Furosemide affects diabetes mellitus"" supported by the sentence: ""[USE OF FUROSEMIDE (LASIX) IN GERIATRICS. CONTRIBUTION TO THE EVALUATION OF THE SO-CALLED DIABETOGENIC EFFECT OF SALIDIURETICS].""?",False, +8299615,Furosemide affects acute kidney failure,3205,Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.,"Is the triple ""Furosemide affects acute kidney failure"" supported by the sentence: ""Frusemide administered in group 3 had a favourable effect on the acute renal failure induced by FA.""?",False, +27482854,Furosemide disrupts Edema,3206,Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.,"Is the triple ""Furosemide disrupts Edema"" supported by the sentence: ""Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release.""?",False, +19844878,Furosemide disrupts Dyspnea,3207,"At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.","Is the triple ""Furosemide disrupts Dyspnea"" supported by the sentence: ""At the PETCO2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., >20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.""?",False, +24717003,Furosemide prevents pulmonary edema,3208,"Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.","Is the triple ""Furosemide prevents pulmonary edema"" supported by the sentence: ""Within the conservative arm, furosemide to reduce pulmonary edema and improve lung function has spawned several discussions given the concerns for its upregulation of prostaglandin E 2 in the kidneys and conflicting outcomes data.""?",False, +22953098,Furosemide prevents Dyspnea,3209,"Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.","Is the triple ""Furosemide prevents Dyspnea"" supported by the sentence: ""Results: According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide.""?",False, +21527038,Furosemide prevents schizophrenia,3210,"Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.","Is the triple ""Furosemide prevents schizophrenia"" supported by the sentence: ""Furthermore, we suggest that reduced levels of an ASD-related genetic factor in unaffected FRs may help protect against SCZ development.""?",False, +20769925,Furosemide prevents bronchopulmonary dysplasia,3211,CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.,"Is the triple ""Furosemide prevents bronchopulmonary dysplasia"" supported by the sentence: ""CONCLUSIONS: More days of furosemide exposure between postnatal day 7 and 36 weeks was associated with decreased risk of BPD and a combined outcome of BPD or death.""?",False, +12415888,Furosemide prevents kidney disorder,3212,The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.,"Is the triple ""Furosemide prevents kidney disorder"" supported by the sentence: ""The purpose of the current study was to evaluate the efficacy of oral saline hydration and of intravenous saline hydration plus theophylline or furosemide for the prevention of CN.""?",False, +11075685,Furosemide prevents hypertensive disorder,3213,"The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.","Is the triple ""Furosemide prevents hypertensive disorder"" supported by the sentence: ""The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet.""?",False, +9165205,Furosemide prevents Edema,3214,Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.,"Is the triple ""Furosemide prevents Edema"" supported by the sentence: ""Prevention of body fluid retention by furosemide during estrogen therapy of prostatic cancer.""?",False, +8733555,Furosemide prevents syndromic disease,3215,"The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".","Is the triple ""Furosemide prevents syndromic disease"" supported by the sentence: ""The infusional therapy included human albumin and fresh frozen plasma to substitute losses and furosemide at the dose of 4 mg/kg/day to reduce the ""leaky capillary syndrome"".""?",False, +7901682,Furosemide prevents kidney failure,3216,"In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.","Is the triple ""Furosemide prevents kidney failure"" supported by the sentence: ""In a double-blind randomized controlled trial, the effectiveness of dopamine or furosemide in prevention of renal impairment after cardiac surgery was evaluated.""?",False, +24388792,Furosemide predisposes acute kidney failure,3217,Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?,"Is the triple ""Furosemide predisposes acute kidney failure"" supported by the sentence: ""Can really preoperative furosemide increase the risk of acute kidney injury after coronary artery bypass grafting?""?",False, +23800241,Furosemide predisposes myocardial infarction,3218,"METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).","Is the triple ""Furosemide predisposes myocardial infarction"" supported by the sentence: ""METHODS: In healthy Singaporeans enrolled in the SingHEART study (in the absence of any clinical outcomes), we investigated potential improvements in the SG FRS to predict myocardial infarction risk based on high/low classifications of the Agatston score (surrogate outcome).""?",False, +21525697,Furosemide predisposes atherosclerosis,3219,"RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).","Is the triple ""Furosemide predisposes atherosclerosis"" supported by the sentence: ""RESULTS: Among 988 participants (mean age 52 years, 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (SD 7.1%) and FRS was 13.1% (SD 10.7%).""?",False, +16660855,Furosemide predisposes kidney disorder,3220,"Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).","Is the triple ""Furosemide predisposes kidney disorder"" supported by the sentence: ""Furosemide was shown to increase the risk of CIN (RR 3.27, 95% CI 1.48-7.26, I(2)=0%).""?",False, +19565633,Nabumetone physically interacts with Cyclooxygenase 2,3221,"The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.""?",False, +14176438,Nabumetone physically interacts with Cyclooxygenase 2,3222,"Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.","Is the triple ""Nabumetone physically interacts with Cyclooxygenase 2"" supported by the sentence: ""Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.""?",False, +15189827,Nabumetone affects osteoarthritis,3223,Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.,"Is the triple ""Nabumetone affects osteoarthritis"" supported by the sentence: ""Analgesic activity of nabumetone versus naproxen in acute exacerbation of osteoarthritis.""?",False, +9219116,Nabumetone affects Cyclooxygenase 2,3224,"Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.","Is the triple ""Nabumetone affects Cyclooxygenase 2"" supported by the sentence: ""Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.""?",False, +11784119,Selegiline related to Parkinson disease,3225,Long-term experience with selegiline and levodopa in Parkinson's disease.,"Is the triple ""Selegiline related to Parkinson disease"" supported by the sentence: ""Long-term experience with selegiline and levodopa in Parkinson's disease.""?",False, +7091710,Selegiline related to Monoamine Oxidase B,3226,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, +7091710,Selegiline related to Monoamine Oxidase B,3227,"We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.","Is the triple ""Selegiline related to Monoamine Oxidase B"" supported by the sentence: ""We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine.""?",False, +26670675,Selegiline coexists with Monoamine Oxidase B,3228,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, +26670675,Selegiline coexists with Monoamine Oxidase B,3229,"The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.","Is the triple ""Selegiline coexists with Monoamine Oxidase B"" supported by the sentence: ""The lower dose of L-deprenyl caused only a slight decrease in MAO-B activity, whereas the 5-mg/kg/day dose remarkably reduced it.""?",False, +13016594,Selegiline physically interacts with Monoamine Oxidase B,3230,L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.,"Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""L-deprenyl binds to MAO-B and autoradiography with 3H-L-deprenyl has been used to map astrocytosis in vitro.""?",False, +26762387,Selegiline physically interacts with Monoamine Oxidase B,3231,"MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.","Is the triple ""Selegiline physically interacts with Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition explains the clinical efficacy of l-deprenyl in the treatment of Parkinson's disease and the prevention of the conversion of protoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which is oxidized by MAO-B and can cause a parkinsonian syndrome, to their active neurotoxin.""?",False, +27251718,Selegiline causes depressive disorder,3232,These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.,"Is the triple ""Selegiline causes depressive disorder"" supported by the sentence: ""These results indicate that the monoamine oxidase type B inhibitory ability leading to an increase of the dopaminergic tonus in the hippocampus is involved in the L-deprenyl-induced depression of excitatory synaptic transmission in the CA1 region of the rat hippocampus.""?",False, +18216942,Selegiline causes Parkinson disease,3233,Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.,"Is the triple ""Selegiline causes Parkinson disease"" supported by the sentence: ""Selegiline and Piribedil have neuroprotective effects to induced PD Wistar rat with dose-dependent effect.""?",False, +8842901,Selegiline affects Parkinson disease,3234,Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.,"Is the triple ""Selegiline affects Parkinson disease"" supported by the sentence: ""Long-term persistence of symptomatic effect of selegiline in Parkinson's disease.""?",False, +7091708,Selegiline affects Monoamine Oxidase B,3235,"In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.","Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A.""?",False, +8615177,Selegiline affects Monoamine Oxidase B,3236,MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.,"Is the triple ""Selegiline affects Monoamine Oxidase B"" supported by the sentence: ""MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.""?",False, +11022843,Selegiline disrupts Parkinson disease,3237,"Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.","Is the triple ""Selegiline disrupts Parkinson disease"" supported by the sentence: ""Beside the actual clinical effect on disability, selegiline slowed down the progression of Parkinson's disease.""?",False, +8202759,Selegiline prevents depressive disorder,3238,"The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.","Is the triple ""Selegiline prevents depressive disorder"" supported by the sentence: ""The findings of the present study demonstrate that the selective MAO inhibitors, moclobemide and selegiline, protect against ""behavioral depression"" induced by the chronic stress similarly to other classes of antidepressant drugs.""?",False, +7205408,Selegiline prevents Parkinson disease,3239,Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.,"Is the triple ""Selegiline prevents Parkinson disease"" supported by the sentence: ""Selegiline affords neuroprotection for dopamine neurons in cell culture systems and the results of several clinical trials are consistent with the hypothesis that it is neuroprotective in Parkinson's disease.""?",False, +21543223,Bumetanide causes pervasive developmental disorder,3240,This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.,"Is the triple ""Bumetanide causes pervasive developmental disorder"" supported by the sentence: ""This case report suggests that Vitamin D3 and bumetanide target different mechanisms in the pathogenesis of ASD.""?",False, +22325231,Bumetanide affects pervasive developmental disorder,3241,"Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).","Is the triple ""Bumetanide affects pervasive developmental disorder"" supported by the sentence: ""Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase Two, Superiority Trial.OBJECTIVE: Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD).""?",False, +20190253,Bumetanide affects autism spectrum disorder,3242,Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.,"Is the triple ""Bumetanide affects autism spectrum disorder"" supported by the sentence: ""Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.""?",False, +16914848,Bumetanide prevents autism spectrum disorder,3243,"UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.","Is the triple ""Bumetanide prevents autism spectrum disorder"" supported by the sentence: ""UNLABELLED: We report that daily administration of the diuretic NKCC1 chloride co-transporter, bumetanide, reduces the severity of autism in a 10-year-old Fragile X boy using CARS, ADOS, ABC, RDEG and RRB before and after treatment.""?",False, +11943751,D-Glucosamine related to breast neoplasm,3244,Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.,"Is the triple ""D-Glucosamine related to breast neoplasm"" supported by the sentence: ""Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors.""?",False, +7809202,D-Glucosamine related to osteoarthritis,3245,Glucosamine in osteoarthritis.,"Is the triple ""D-Glucosamine related to osteoarthritis"" supported by the sentence: ""Glucosamine in osteoarthritis.""?",False, +27619077,D-Glucosamine causes obesity disorder,3246,"Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.","Is the triple ""D-Glucosamine causes obesity disorder"" supported by the sentence: ""Finally, incubation of 3T3-L1 pre-adipocytes and L6 myocytes with glucosamine rapidly induces ob gene expression.""?",False, +18633463,D-Glucosamine causes osteoarthritis,3247,Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.,"Is the triple ""D-Glucosamine causes osteoarthritis"" supported by the sentence: ""Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.""?",False, +9909825,D-Glucosamine affects osteoarthritis,3248,The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.,"Is the triple ""D-Glucosamine affects osteoarthritis"" supported by the sentence: ""The food supplement glucosamine has been claimed to modify progression of osteoarthritis and is being extensively marketed as a treatment for patients with the condition.""?",False, +8968754,D-Glucosamine affects obesity disorder,3249,Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).,"Is the triple ""D-Glucosamine affects obesity disorder"" supported by the sentence: ""Central to the paper is the finding that glucosamine can up-regulate the obese (ob) gene by acting on a 'nutrient-sensing' pathway (1).""?",False, +13460623,D-Glucosamine disrupts osteoarthritis,3250,"Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.","Is the triple ""D-Glucosamine disrupts osteoarthritis"" supported by the sentence: ""Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated.""?",False, +11817662,D-Glucosamine prevents osteoarthritis,3251,"OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.","Is the triple ""D-Glucosamine prevents osteoarthritis"" supported by the sentence: ""OBJECTIVE: Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans.""?",False, +25749858,Torsemide causes hypertensive disorder,3252,Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.,"Is the triple ""Torsemide causes hypertensive disorder"" supported by the sentence: ""Torasemide at a daily oral dose of 5 mg/kg for 12 days effectively reduced the arterial blood pressure in desoxycortone induced hypertension in the rat.""?",False, +26478746,Torsemide affects hypertensive disorder,3253,"The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.","Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""The new loop diuretics, including torasemide, have been shown to reduce the raised pulmonary vascular pressures without significant depression of the cardiac output in patients with chronic heart failure.""?",False, +13754465,Torsemide affects hypertensive disorder,3254,Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.,"Is the triple ""Torsemide affects hypertensive disorder"" supported by the sentence: ""Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.""?",False, +24478260,Leuprorelin related to infertility disorder,3255,Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.,"Is the triple ""Leuprorelin related to infertility disorder"" supported by the sentence: ""Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence.""?",False, +22375547,Leuprorelin related to neoplasm,3256,"For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.","Is the triple ""Leuprorelin related to neoplasm"" supported by the sentence: ""For a test set of 32 large molecules (e.g., cyclosporine A, gramicidin A, leuprolide, nafarelin, oxytocin, vancomycin, and mostly natural-product-derived therapeutics used in infectious/viral diseases, in immunosuppression, and in oncology) the modified equation predicted the intrinsic solubility with a root-mean-square error of 1.10 log unit, compared to 3.0 by the traditional GSE, and 1.07 by RFR.""?",False, +17696905,Leuprorelin related to leiomyoma,3257,"Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.","Is the triple ""Leuprorelin related to leiomyoma"" supported by the sentence: ""Injections of the gonadorelin agonists leuprorelin or triptorelin reduce bleeding associated with leiomyomas, according to several randomised trials.""?",False, +16368292,Leuprorelin related to prostate cancer,3258,OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.,"Is the triple ""Leuprorelin related to prostate cancer"" supported by the sentence: ""OBJECTIVE: To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer.""?",False, +15413679,Leuprorelin related to endometriosis,3259,The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.,"Is the triple ""Leuprorelin related to endometriosis"" supported by the sentence: ""The combination therapy (16/17) was also shown to be superior to danazol (9/20) or leuprolide alone (14/24) to induce the regression of fluid in experimental endometriosis.""?",False, +9878755,Leuprorelin causes hypogonadism,3260,"Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.","Is the triple ""Leuprorelin causes hypogonadism"" supported by the sentence: ""Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids.""?",False, +7418968,Leuprorelin causes neoplasm,3261,"In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.","Is the triple ""Leuprorelin causes neoplasm"" supported by the sentence: ""In addition, when CEP-701 was given sequentially to rats bearing H tumors, which were progressing in the presence of continuous androgen ablation induced by Leuprolide, regression of the androgen-independent tumors occurred.""?",False, +27571709,Leuprorelin affects prostate cancer,3262,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, +27571708,Leuprorelin affects endometriosis,3263,"The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""The clinical efficacy of these injectable microcapsules of leuprorelin has been widely proved for prostate cancer, endometriosis, and other sex hormone dependent diseases in about sixty countries.""?",False, +26547561,Leuprorelin affects endometriosis,3264,"Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.","Is the triple ""Leuprorelin affects endometriosis"" supported by the sentence: ""Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.""?",False, +26152029,Leuprorelin affects prostate cancer,3265,Endocrine and clinical effects of leuprolide in prostatic cancer.,"Is the triple ""Leuprorelin affects prostate cancer"" supported by the sentence: ""Endocrine and clinical effects of leuprolide in prostatic cancer.""?",False, +27542556,Leuprorelin prevents neoplasm,3266,In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.,"Is the triple ""Leuprorelin prevents neoplasm"" supported by the sentence: ""In the present study the capacity of leuprolide to prevent tumor development was evaluated by comparing its pretreatment effects in the DMBA-induced rat mammary carcinoma model to pretreatment with tamoxifen and oophorectomy.""?",False, +12402472,Leuprorelin prevents Pain,3267,"CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.","Is the triple ""Leuprorelin prevents Pain"" supported by the sentence: ""CONCLUSION(S): Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.""?",False, +7814590,Sodium Bicarbonate subclass of Electrolytes,3268,"Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.","Is the triple ""Sodium Bicarbonate subclass of Electrolytes"" supported by the sentence: ""Electrolytes such as sodium bicarbonate or pentasodium tripolyphosphate were used to modulate intragel pH dynamics, swelling kinetics, and gel properties.""?",False, +26447678,Sodium Bicarbonate related to cystic fibrosis,3269,Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.,"Is the triple ""Sodium Bicarbonate related to cystic fibrosis"" supported by the sentence: ""Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.""?",False, +26270339,Sodium Bicarbonate related to kidney failure,3270,"Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.","Is the triple ""Sodium Bicarbonate related to kidney failure"" supported by the sentence: ""Since bicarbonate has been reported to elicit fast recovery from acute renal failure in man, clearance studies were performed to compare the effects of sodium bicarbonate and saline infusion on renal function in postischaemic renal failure in the rat.""?",False, +20718850,Sodium Bicarbonate related to acidosis disorder,3271,There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.,"Is the triple ""Sodium Bicarbonate related to acidosis disorder"" supported by the sentence: ""There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate.""?",False, +15047625,Sodium Bicarbonate related to Pain,3272,"We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.","Is the triple ""Sodium Bicarbonate related to Pain"" supported by the sentence: ""We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.""?",False, +14688492,Sodium Bicarbonate related to chronic renal failure syndrome,3273,"We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.","Is the triple ""Sodium Bicarbonate related to chronic renal failure syndrome"" supported by the sentence: ""We suggest specific vasodilators [corrected] under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.""?",False, +13166244,Sodium Bicarbonate related to kidney disorder,3274,REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.,"Is the triple ""Sodium Bicarbonate related to kidney disorder"" supported by the sentence: ""REMEDIAL: a role for sodium bicarbonate in the prevention of contrast-induced nephropathy.""?",False, +12100581,Sodium Bicarbonate physically interacts with Electrolytes,3275,"NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate, and Potassium Chloride for Oral Solution), a product from Braintree Laboratories, Inc. is a modification of GoLYTELY (PEG 3350 and Electrolytes for Oral Solution) that has been found to have the same therapeutic advantages in terms of safety, efficacy, speed and patient acceptance.""?",False, +13772853,Sodium Bicarbonate physically interacts with Electrolytes,3276,"Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.","Is the triple ""Sodium Bicarbonate physically interacts with Electrolytes"" supported by the sentence: ""Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.""?",False, +27495118,Sodium Bicarbonate causes kidney failure,3277,"In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.","Is the triple ""Sodium Bicarbonate causes kidney failure"" supported by the sentence: ""In the second group of dogs, following induction of renal failure, sodium bicarbonate was given orally in an amount sufficient to neutralize endogenous acid production.""?",False, +18327883,Sodium Bicarbonate causes kidney disorder,3278,This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.,"Is the triple ""Sodium Bicarbonate causes kidney disorder"" supported by the sentence: ""This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes.""?",False, +14549296,Sodium Bicarbonate causes injury,3279,Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.,"Is the triple ""Sodium Bicarbonate causes injury"" supported by the sentence: ""Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis.""?",False, +8914995,Sodium Bicarbonate causes acidosis disorder,3280,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate causes acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, +25712033,Sodium Bicarbonate affects Abnormality of acid-base homeostasis,3281,An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.,"Is the triple ""Sodium Bicarbonate affects Abnormality of acid-base homeostasis"" supported by the sentence: ""An isotonic solution of sodium bicarbonate or ammonium chloride was simultaneously infused to study the effect of acid-base imbalance on the clearances.""?",False, +18411502,Sodium Bicarbonate affects injury,3282,OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.,"Is the triple ""Sodium Bicarbonate affects injury"" supported by the sentence: ""OBJECTIVE: The aim of this study was to determine whether or not perioperative administration of sodium bicarbonate had a preventive effect on cardiac surgery-associated acute kidney injury (CSA-AKI) as shown in randomized controlled trials.""?",False, +17654743,Sodium Bicarbonate affects kidney disorder,3283,"Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.","Is the triple ""Sodium Bicarbonate affects kidney disorder"" supported by the sentence: ""Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.""?",False, +12960490,Sodium Bicarbonate affects Pain,3284,Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.,"Is the triple ""Sodium Bicarbonate affects Pain"" supported by the sentence: ""Secondary objectives were to determine whether adding epinephrine and/or sodium bicarbonate affected infiltration pain.""?",False, +8914994,Sodium Bicarbonate affects acidosis disorder,3285,We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.,"Is the triple ""Sodium Bicarbonate affects acidosis disorder"" supported by the sentence: ""We conclude that sodium bicarbonate may exacerbate cell acidosis under buffering conditions close to those in vivo and that the initial changes in cell pH caused by sodium bicarbonate depend on the extracellular nonbicarbonate buffering capacity.""?",False, +14651482,Sodium Bicarbonate disrupts acidosis disorder,3286,"The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.","Is the triple ""Sodium Bicarbonate disrupts acidosis disorder"" supported by the sentence: ""The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium.""?",False, +21103228,Sodium Bicarbonate prevents acidosis disorder,3287,According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.,"Is the triple ""Sodium Bicarbonate prevents acidosis disorder"" supported by the sentence: ""According to recent literature sodium bicarbonate (NaHCO3) has been proposed as a performance enhancing aid by reducing acidosis during exercise.""?",False, +13938650,Sodium Bicarbonate prevents injury,3288,Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.,"Is the triple ""Sodium Bicarbonate prevents injury"" supported by the sentence: ""Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis.""?",False, +11746267,Sodium Bicarbonate prevents kidney failure,3289,"SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.","Is the triple ""Sodium Bicarbonate prevents kidney failure"" supported by the sentence: ""SUMMARY: Among the recent studies in humans, the most intriguing have been the use of atrial natriuretic peptide in patients with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast medium-induced renal failure.""?",False, +11205688,Sodium Bicarbonate prevents acute kidney failure,3290,Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.,"Is the triple ""Sodium Bicarbonate prevents acute kidney failure"" supported by the sentence: ""Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure.""?",False, +11205686,Sodium Bicarbonate prevents kidney disorder,3291,Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.,"Is the triple ""Sodium Bicarbonate prevents kidney disorder"" supported by the sentence: ""Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.""?",False, +14663272,Sodium Bicarbonate predisposes kidney disorder,3292,PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.,"Is the triple ""Sodium Bicarbonate predisposes kidney disorder"" supported by the sentence: ""PURPOSE: To determine the effect of sodium bicarbonate on the risk for CIN.""?",False, +14542214,Sodium Bicarbonate predisposes injury,3293,"We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.","Is the triple ""Sodium Bicarbonate predisposes injury"" supported by the sentence: ""We found a preventive effect of the use of sodium bicarbonate on the risk for CI-AKI, however, with borderline statistical significance.""?",False, +17530350,Olmesartan medoxomil affects diabetic kidney disease,3294,Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.,"Is the triple ""Olmesartan medoxomil affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin-induced diabetes in rats.""?",False, +12894557,Olmesartan medoxomil affects atherosclerosis,3295,Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.,"Is the triple ""Olmesartan medoxomil affects atherosclerosis"" supported by the sentence: ""Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.""?",False, +12254737,Olmesartan medoxomil affects diabetes mellitus,3296,A further evaluation of the effects of OM in diabetes is warranted.,"Is the triple ""Olmesartan medoxomil affects diabetes mellitus"" supported by the sentence: ""A further evaluation of the effects of OM in diabetes is warranted.""?",False, +15583038,Olmesartan medoxomil disrupts hypertensive disorder,3297,"Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.","Is the triple ""Olmesartan medoxomil disrupts hypertensive disorder"" supported by the sentence: ""Significantly greater reductions in seated diastolic BP were observed between baseline and after eight weeks of treatment with olmesartan/amlodipine, compared with equivalent doses of olmesartan or amolodipine monotherapy (P < 0.001), in the factorial Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial.""?",False, +12254736,Olmesartan medoxomil disrupts proteinuria,3298,"These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).","Is the triple ""Olmesartan medoxomil disrupts proteinuria"" supported by the sentence: ""These doses of OM reduced BP and dose-dependently reduced proteinuria 31% and 76%, respectively, in hypertensive ZDF rats (P < 0.01).""?",False, +12254735,Olmesartan medoxomil prevents hypertensive disorder,3299,"At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.","Is the triple ""Olmesartan medoxomil prevents hypertensive disorder"" supported by the sentence: ""At doses of 0.6 and 6.0 mg/kg/day, OM significantly reduces hypertension associated with type 2 diabetes.""?",False, +9359700,Olmesartan medoxomil prevents atherosclerosis,3300,This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.,"Is the triple ""Olmesartan medoxomil prevents atherosclerosis"" supported by the sentence: ""This article reviews recent research showing that administration of the angiotensin II type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis.""?",False, +8752749,Candesartan related to essential hypertension,3301,Comparison of candesartan versus enalapril in essential hypertension.,"Is the triple ""Candesartan related to essential hypertension"" supported by the sentence: ""Comparison of candesartan versus enalapril in essential hypertension.""?",False, +20752265,Candesartan causes Cognitive impairment,3302,"Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.","Is the triple ""Candesartan causes Cognitive impairment"" supported by the sentence: ""Although our data provides evidences of the protective role of Candesartan against EMW-induced cognitive decline, more future studies are still needed to confirm these findings which can provide new fields in treatment of EMW-induced damage by Candesartan.""?",False, +14838058,Candesartan causes hypertensive disorder,3303,"Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.","Is the triple ""Candesartan causes hypertensive disorder"" supported by the sentence: ""Candesartan lowered the blood pressure regardless of age, sex, BMI or cause of hypertension.""?",False, +20512666,Candesartan affects Cognitive impairment,3304,"We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""We hypothesized that AT2R stimulation, either directly with C21, or indirectly by blocking the angiotensin type 1 receptor (AT1R) with candesartan, initiated after stroke, would reduce cognitive impairment.""?",False, +20051167,Candesartan affects hypertensive disorder,3305,"Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease.""?",False, +19501045,Candesartan affects Cognitive impairment,3306,"METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.","Is the triple ""Candesartan affects Cognitive impairment"" supported by the sentence: ""METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks.""?",False, +14118850,Candesartan affects Left ventricular hypertrophy,3307,"The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.","Is the triple ""Candesartan affects Left ventricular hypertrophy"" supported by the sentence: ""The effects of candesartan on left ventricular hypertrophy and function in nonobstructive hypertrophic cardiomyopathy: a pilot, randomized study.""?",False, +9919312,Candesartan affects hypertensive disorder,3308,"RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).","Is the triple ""Candesartan affects hypertensive disorder"" supported by the sentence: ""RESULTS: Compared to WKY + Veh, the elevated BP of SHR + Veh (153 +/- 3 vs 115 +/- 3 mm Hg; P < 0.001) was normalized by Cand (117 +/- 4) or HHR (113 +/- 5 mm Hg).""?",False, +14542524,Candesartan disrupts Left ventricular hypertrophy,3309,"A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.","Is the triple ""Candesartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD.""?",False, +9479295,Candesartan disrupts hypertensive disorder,3310,Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.,"Is the triple ""Candesartan disrupts hypertensive disorder"" supported by the sentence: ""Chronic treatment with enalapril or candesartan inhibited the development of hypertension and cardiac hypertrophy equally in SHR.""?",False, +24756017,Candesartan prevents Cognitive impairment,3311,"Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.","Is the triple ""Candesartan prevents Cognitive impairment"" supported by the sentence: ""Results: Low-dose candesartan prevented the development of cognitive impairment, otherwise associated with accelerated aging, in SAMP8 mice, by reducing inflammation and nitro-oxidative stress.""?",False, +15502429,Candesartan prevents cardiovascular disorder,3312,"The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).","Is the triple ""Candesartan prevents cardiovascular disorder"" supported by the sentence: ""The authors have previously shown that candesartan lowered the risk of all CVD (primary composite end point) more so than losartan (adjusted hazard ratio, 0.86; 95% confidence interval, 0.77-0.96).""?",False, +12994289,Candesartan prevents Left ventricular hypertrophy,3313,"Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.","Is the triple ""Candesartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Thus, a candesartan-based regimen for six months significantly reduced echocardiographic LVH in hypertensive patients in general practice.""?",False, +12444324,Candesartan prevents atrial fibrillation,3314,"CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.","Is the triple ""Candesartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Treatment with the angiotensin receptor blocker candesartan reduced the incidence of AF in a large, broadly-based, population of patients with symptomatic CHF.""?",False, +12421723,Candesartan prevents migraine disorder,3315,"CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.","Is the triple ""Candesartan prevents migraine disorder"" supported by the sentence: ""CONCLUSIONS: The favorable results and low rate of adverse effects, in this open migraine prevention study in patients with hypertension or prehypertension, are similar to results of the randomized, double-blind, placebo-controlled, crossover study in patients taking candesartan.""?",False, +8787605,Candesartan prevents hypertensive disorder,3316,"When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.","Is the triple ""Candesartan prevents hypertensive disorder"" supported by the sentence: ""When hypertension was reduced using captopril or candesartan, retinal KDR expression returned to baseline levels.""?",False, +9420113,Telmisartan related to diabetes mellitus,3317,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to diabetes mellitus"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, +9420112,Telmisartan related to hypertensive disorder,3318,This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.,"Is the triple ""Telmisartan related to hypertensive disorder"" supported by the sentence: ""This study compared the cardiovascular and renal effects of long-term telmisartan (3 and 10 mg/kg/day)and lisinopril (10 mg/kg/day) in an animal model combining hypertension and diabetes mellitus.""?",False, +16669618,Telmisartan causes cardiovascular disorder,3319,These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.,"Is the triple ""Telmisartan causes cardiovascular disorder"" supported by the sentence: ""These findings demonstrate that telmisartan can have significant effects on mitochondrial metabolism in VSMC that are potentially relevant to the pathogenesis of cardiovascular disease and that involve more than just angiotensin receptor blockade and activation of PPARgamma.""?",False, +16637024,Telmisartan causes hypertensive disorder,3320,Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.,"Is the triple ""Telmisartan causes hypertensive disorder"" supported by the sentence: ""Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals.""?",False, +16559226,Telmisartan causes myocardial infarction,3321,"Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.","Is the triple ""Telmisartan causes myocardial infarction"" supported by the sentence: ""Above 30 MUM, telmisartan may potentially cause cardiac cell death and MI.""?",False, +14418892,Telmisartan causes Albuminuria,3322,CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.,"Is the triple ""Telmisartan causes Albuminuria"" supported by the sentence: ""CONCLUSION: The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.""?",False, +13301662,Telmisartan causes diabetes mellitus,3323,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Telmisartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, +20835589,Telmisartan affects diabetic kidney disease,3324,This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.,"Is the triple ""Telmisartan affects diabetic kidney disease"" supported by the sentence: ""This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism.""?",False, +17882285,Telmisartan affects Albuminuria,3325,"Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Since genetic variants associated with estimated glomerular filtration rate (eGFR) were identified in cross sectional studies, we asked whether these variants were also associated with rate of increase in albuminuria among patients with diabetes from ONTARGET and TRANSCEND-randomized controlled trials of ramipril, telmisartan, both, or placebo.""?",False, +16266744,Telmisartan affects Albuminuria,3326,Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.,"Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials.""?",False, +15802746,Telmisartan affects diabetes mellitus,3327,"Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs.""?",False, +13992848,Telmisartan affects diabetes mellitus,3328,"Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.","Is the triple ""Telmisartan affects diabetes mellitus"" supported by the sentence: ""Telmisartan and ramipril were equivalent, but their combination increased adverse events in vascular disease or diabetes.""?",False, +13861721,Telmisartan affects type 2 diabetes mellitus,3329,Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.,"Is the triple ""Telmisartan affects type 2 diabetes mellitus"" supported by the sentence: ""Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.""?",False, +13824093,Telmisartan affects Albuminuria,3330,"An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.","Is the triple ""Telmisartan affects Albuminuria"" supported by the sentence: ""An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan.""?",False, +13501012,Telmisartan affects essential hypertension,3331,CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.,"Is the triple ""Telmisartan affects essential hypertension"" supported by the sentence: ""CONCLUSIONS: The ABP lowering effects of telmisartan were dependent on PRA levels before treatment in patients with essential hypertension.""?",False, +13178302,Telmisartan affects hypertensive disorder,3332,"In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.","Is the triple ""Telmisartan affects hypertensive disorder"" supported by the sentence: ""In the present study the effect of Telmisartan on hypertension, parameters of glucose and lipid metabolism was investigated in 670 patients with the metabolic syndrome.""?",False, +25051574,Telmisartan disrupts Alzheimer disease,3333,"RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).","Is the triple ""Telmisartan disrupts Alzheimer disease"" supported by the sentence: ""RESULTS: We identified that moderate/high telmisartan exposure was significantly associated with a reduced incidence of AD in the AAs compared to low/no telmisartan exposure (hazard ratio [HR] = 0.77, 95% CI: 0.65-0.91, p-value = 0.0022), but not in the non-Hispanic EAs (HR = 0.97, 95% CI: 0.89-1.05, p-value = 0.4110).""?",False, +14418891,Telmisartan disrupts Albuminuria,3334,RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.,"Is the triple ""Telmisartan disrupts Albuminuria"" supported by the sentence: ""RESULTS: The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h.""?",False, +13325686,Telmisartan disrupts hypertensive disorder,3335,"WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.","Is the triple ""Telmisartan disrupts hypertensive disorder"" supported by the sentence: ""WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats.""?",False, +21182197,Telmisartan prevents Alzheimer disease,3336,Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.,"Is the triple ""Telmisartan prevents Alzheimer disease"" supported by the sentence: ""Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.""?",False, +17513403,Telmisartan prevents myocardial infarction,3337,This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.,"Is the triple ""Telmisartan prevents myocardial infarction"" supported by the sentence: ""This post-hoc analysis suggests that MI may be further reduced by telmisartan in hypertensive patients.""?",False, +17170882,Telmisartan prevents type 2 diabetes mellitus,3338,"OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).","Is the triple ""Telmisartan prevents type 2 diabetes mellitus"" supported by the sentence: ""OBJECTIVES: This study aims to investigate the effects of telmisartan, pioglitazone and metformin administration on the prevention of new-onset type 2 diabetes mellitus in pre-diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed with a high-fat diet (HFD).""?",False, +13010398,Telmisartan prevents stroke disorder,3339,"The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.","Is the triple ""Telmisartan prevents stroke disorder"" supported by the sentence: ""The ongoing PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial is designed to evaluate whether ASA + extended-release DP compared to clopidogrel, and whether telmisartan in addition to usual care in individuals after a stroke, will reduce the risk of further strokes.""?",False, +12278433,Telmisartan prevents diabetic kidney disease,3340,"In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.","Is the triple ""Telmisartan prevents diabetic kidney disease"" supported by the sentence: ""In the VIVALDI trial, the ability of the angiotensin receptor blocker telmisartan to reduce the progression of diabetic nephropathy (associated with proteinuria) in comparison with valsartan in more than 800 patients with type 2 diabetes during 1 year of treatment is being studied.""?",False, +11585228,Telmisartan prevents diabetes mellitus,3341,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents diabetes mellitus"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, +11585227,Telmisartan prevents cardiovascular disorder,3342,Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?,"Is the triple ""Telmisartan prevents cardiovascular disorder"" supported by the sentence: ""Does telmisartan reduce the development of diabetes and CVD in insulin resistant patients pretreated with maximal doses of other ARBs?""?",False, +11473935,Telmisartan prevents hypertensive disorder,3343,"In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.","Is the triple ""Telmisartan prevents hypertensive disorder"" supported by the sentence: ""In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated.""?",False, +17028323,Telmisartan predisposes stroke disorder,3344,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes stroke disorder"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, +17028322,Telmisartan predisposes myocardial infarction,3345,"We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.","Is the triple ""Telmisartan predisposes myocardial infarction"" supported by the sentence: ""We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers.""?",False, +21651336,Irbesartan causes hypertensive disorder,3346,"The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.","Is the triple ""Irbesartan causes hypertensive disorder"" supported by the sentence: ""The formation of solid dispersion through dissolution method while induction of hypertension using 2.5% NaCl and prednisone 1.5 mg/Kg BB orally in 3 treatment groups, irbesartan dose was 13.5 mg/kg.""?",False, +19454247,Irbesartan affects Sepsis,3347,Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.,"Is the triple ""Irbesartan affects Sepsis"" supported by the sentence: ""Cardioprotective effects of irbesartan in polymicrobial sepsis : The role of the p38MAPK/NF-kappaB signaling pathway.""?",False, +13143483,Irbesartan affects type 2 diabetes mellitus,3348,CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.,"Is the triple ""Irbesartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSION: The profound blood pressure-lowering and renoprotective effect of irbesartan in type 2 diabetes documented in clinical endpoint studies was confirmed in second-line therapy in a large sample of primary-care patients.""?",False, +9015828,Irbesartan affects chronic kidney disease,3349,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects chronic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, +9015827,Irbesartan affects diabetic kidney disease,3350,PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.,"Is the triple ""Irbesartan affects diabetic kidney disease"" supported by the sentence: ""PRIME is evaluating the effects of irbesartan in preventing diabetic nephropathy and end-stage renal failure and in reducing cardiovascular events in high-risk hypertensive patients with type 2 diabetes.""?",False, +7812861,Irbesartan affects acute kidney failure,3351,[Acute renal failure associated with irbesartan].,"Is the triple ""Irbesartan affects acute kidney failure"" supported by the sentence: ""[Acute renal failure associated with irbesartan].""?",False, +19016605,Irbesartan disrupts atrial fibrillation,3352,Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.,"Is the triple ""Irbesartan disrupts atrial fibrillation"" supported by the sentence: ""Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.""?",False, +11936096,Irbesartan disrupts hypertensive disorder,3353,"Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.","Is the triple ""Irbesartan disrupts hypertensive disorder"" supported by the sentence: ""Recent outcomes studies--Losartan Intervention For Endpoint reduction in hypertension, Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan, and the Irbesartan Type 2 Diabetic Nephropathy Trial--suggest that some angiotensin II antagonists are associated with CV and renal effects beyond their ability to lower BP in patients with hypertension or diabetic nephropathy and may play a role in the prevention of new-onset type 2 diabetes.""?",False, +9297339,Irbesartan disrupts diabetic kidney disease,3354,Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.,"Is the triple ""Irbesartan disrupts diabetic kidney disease"" supported by the sentence: ""Irbesartan slows the development of diabetic nephropathy by up to 70% in hypertensive diabetic patients.""?",False, +11467158,Irbesartan prevents chronic kidney disease,3355,"In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.","Is the triple ""Irbesartan prevents chronic kidney disease"" supported by the sentence: ""In both Spanish and U.S. settings, irbesartan was projected to delay the onset of end-stage renal disease (ESRD), reduce the cumulative incidence of ESRD, increase life expectancy, and reduce overall direct medical costs.""?",False, +9856662,Irbesartan prevents diabetic kidney disease,3356,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Irbesartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, +8753962,Irbesartan prevents hypertensive disorder,3357,Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.,"Is the triple ""Irbesartan prevents hypertensive disorder"" supported by the sentence: ""Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.""?",False, +15497727,Irbesartan predisposes cardiovascular disorder,3358,"PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.","Is the triple ""Irbesartan predisposes cardiovascular disorder"" supported by the sentence: ""PATIENTS AND METHODS: Individuals at high CVD risk were randomized to telmisartan (three trials, n=51,878), irbesartan (three trials, n=14,859), valsartan (four trials, n=44,264), candesartan (four trials, n=18,566), and losartan (one trial, n=9193) and followed for 23-60 months.""?",False, +12041301,Irbesartan predisposes IgA glomerulonephritis,3359,OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.,"Is the triple ""Irbesartan predisposes IgA glomerulonephritis"" supported by the sentence: ""OBJECTIVE: To observe the effects of Huobahuagen Tablets combined with irbesartan on the risk factors of IgA nephropathy.""?",False, +9459261,Eprosartan related to essential hypertension,3360,Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.,"Is the triple ""Eprosartan related to essential hypertension"" supported by the sentence: ""Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.""?",False, +8111433,Valsartan related to essential hypertension,3361,"While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.","Is the triple ""Valsartan related to essential hypertension"" supported by the sentence: ""While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.""?",False, +18505936,Valsartan causes myocardial infarction,3362,Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.,"Is the triple ""Valsartan causes myocardial infarction"" supported by the sentence: ""Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.""?",False, +13301661,Valsartan causes diabetes mellitus,3363,"METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.","Is the triple ""Valsartan causes diabetes mellitus"" supported by the sentence: ""METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week.""?",False, +18533693,Valsartan affects hypertensive disorder,3364,"TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.","Is the triple ""Valsartan affects hypertensive disorder"" supported by the sentence: ""TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling.""?",False, +18130226,Valsartan affects stroke disorder,3365,"We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.","Is the triple ""Valsartan affects stroke disorder"" supported by the sentence: ""We aimed to determine whether the effects of levosimendan are comparable to and/or cumulative with those of valsartan, and to investigate whether levosimendan-induced vasodilation has a role in its effects on stroke.""?",False, +16609149,Valsartan affects kidney disorder,3366,"This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.","Is the triple ""Valsartan affects kidney disorder"" supported by the sentence: ""This study investigated whether the angiotensin receptor blocker (ARB) valsartan would delay the progression of kidney disease more effectively than conventional treatment in Japanese hypertensive patients with advanced, predialysis CKD.""?",False, +9837968,Valsartan affects Abnormal left ventricular function,3367,Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.,"Is the triple ""Valsartan affects Abnormal left ventricular function"" supported by the sentence: ""Chronic administration of valsartan blunted the progression of LVF and inhibited the increase in PKC beta.""?",False, +15479686,Valsartan disrupts type 2 diabetes mellitus,3368,These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.,"Is the triple ""Valsartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""These findings may partly explain the beneficial effects of valsartan in the reduced incidence of type 2 diabetes.""?",False, +11438135,Valsartan disrupts atherosclerosis,3369,"Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.","Is the triple ""Valsartan disrupts atherosclerosis"" supported by the sentence: ""Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.""?",False, +20671333,Valsartan prevents Abnormal left ventricular function,3370,"CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.","Is the triple ""Valsartan prevents Abnormal left ventricular function"" supported by the sentence: ""CONCLUSIONS: Reperfusion therapy with SAC/VAL or VAL offers robust acute infarct-sparing benefits; however, SAC/VAL treatment offered superior short-term and long-term benefits in preventing MI-induced LV dysfunction compared with VAL.""?",False, +15012324,Valsartan prevents type 2 diabetes mellitus,3371,"In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.","Is the triple ""Valsartan prevents type 2 diabetes mellitus"" supported by the sentence: ""In contrast, valsartan reduced the incidence of type 2 diabetes by 14%, confirming the potential interest of the blockade of the renin-angiotensin system in this high-risk population.""?",False, +13899819,Valsartan prevents stroke disorder,3372,"Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.","Is the triple ""Valsartan prevents stroke disorder"" supported by the sentence: ""Despite comparable hypotensive effects between valsartan and hydralazine in salt-loaded SHRSP, valsartan reduced cerebral NADPH oxidase activity and ROS more than hydralazine being accompanied by more prevention of stroke by valsartan than hydralazine.""?",False, +12374506,Valsartan prevents diabetes mellitus,3373,"Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.","Is the triple ""Valsartan prevents diabetes mellitus"" supported by the sentence: ""Recently, in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial, valsartan was no more cardioprotective than calcium channel blockers, but was shown to reduce the risk of developing new-onset diabetes in hypertensive patients at high risk of cardiac events compared with calcium antagonist treatment.""?",False, +12038680,Valsartan prevents myocardial infarction,3374,"For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.","Is the triple ""Valsartan prevents myocardial infarction"" supported by the sentence: ""For prevention of myocardial infarction, the published results were more equivocal, because of the benefit of amlodipine over placebo or valsartan in 2 trials, whereas other placebo-controlled trials of calcium-channel blockers or angiotensin converting enzyme inhibitors did not substantiate the expected benefit with regard to cardiac outcomes.""?",False, +11801448,Valsartan prevents atrial fibrillation,3375,CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.,"Is the triple ""Valsartan prevents atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: The results of the present study demonstrate that (a) adding valsartan to prescribed therapy for HF significantly reduces the incidence of AF by 37%; (b) BNP level and advanced age were the strongest independent predictors for AF occurrence; and (c) AF occurrence further worsens the outcome in patients with HF.""?",False, +8617185,Valsartan prevents coronary artery disorder,3376,"Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.","Is the triple ""Valsartan prevents coronary artery disorder"" supported by the sentence: ""Valsartan may prevent the progression of coronary atherosclerosis through an inhibition of Ang II-induced migration and proliferation in these cells, although in vivo evidence is lacking.""?",False, +7691192,Valsartan prevents hypertensive disorder,3377,"Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.","Is the triple ""Valsartan prevents hypertensive disorder"" supported by the sentence: ""Ang II infusion was associated with hypertension, which was prevented by valsartan, but not PD123319.""?",False, +7604460,Valsartan prevents atherosclerosis,3378,CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.,"Is the triple ""Valsartan prevents atherosclerosis"" supported by the sentence: ""CONCLUSION: Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.""?",False, +21524148,Valsartan predisposes myocardial infarction,3379,"Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).","Is the triple ""Valsartan predisposes myocardial infarction"" supported by the sentence: ""Comparisons of two classes of antihypertensive medications with only one study showed that the risk of MI was higher with ARB valsartan versus CCB (HR = 1.19; 95% CI 1.02-1.38, p = 0.02).""?",False, +11133518,Valsartan predisposes cardiovascular disorder,3380,"Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.","Is the triple ""Valsartan predisposes cardiovascular disorder"" supported by the sentence: ""Valsartan selectively blocks angiotensin II binding to the AT1 receptor. ince platelet activation plays a key role in the pathogenesis of vascular disease, and because AT1 receptors are present on the platelet surface, we assessed the in vitro effects of valsartan and its metabolite, valeryl 4-hydroxy valsartan (V4HV), on platelets in 30 subjects with multiple risk factors for cardiovascular disease.""?",False, +13065808,Losartan related to non-alcoholic fatty liver disease,3381,"AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.","Is the triple ""Losartan related to non-alcoholic fatty liver disease"" supported by the sentence: ""AIM: The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.""?",False, +12094342,Losartan related to proteinuria,3382,"The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.","Is the triple ""Losartan related to proteinuria"" supported by the sentence: ""The patient was treated by fluid and salt restriction, enalapril and later also losartan, which led to a decrease in the proteinuria and an increase in serum albumin concentration.""?",False, +11472713,Losartan related to kidney disorder,3383,Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.,"Is the triple ""Losartan related to kidney disorder"" supported by the sentence: ""Combined therapy of enalapril and losartan attenuates histologic progression in immunoglobulin A nephropathy.""?",False, +10013644,Losartan related to hypertensive disorder,3384,"OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.","Is the triple ""Losartan related to hypertensive disorder"" supported by the sentence: ""OBJECTIVES: To compare the efficacy and safety of losartan with enalapril, in mild to moderate hypertension.""?",False, +8975375,Losartan related to IgA glomerulonephritis,3385,Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.,"Is the triple ""Losartan related to IgA glomerulonephritis"" supported by the sentence: ""Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.""?",False, +16215194,Losartan causes injury,3386,"METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.","Is the triple ""Losartan causes injury"" supported by the sentence: ""METHODS: NEP25 mice were treated with the mineralocorticoid receptor blocker (MRB) spironolactone (25 mg/kg/day, n = 10), the ARB losartan (250 mg/kg/day, n = 11), both (ARB+MRB, n = 8) or vehicle (Vehicle, n = 9) from day -7 to day 9 of induction of podocyte injury.""?",False, +15690681,Losartan causes kidney disorder,3387,"Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.","Is the triple ""Losartan causes kidney disorder"" supported by the sentence: ""Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation.""?",False, +9749061,Losartan causes hypertensive disorder,3388,Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.,"Is the triple ""Losartan causes hypertensive disorder"" supported by the sentence: ""Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension.""?",False, +7310301,Losartan causes proteinuria,3389,"In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.","Is the triple ""Losartan causes proteinuria"" supported by the sentence: ""In conclusion, this study provides first-time evidence that the combination of CEI and LOS in normotensive patients with IgA nephropathy produces a more profound decrease in proteinuria than either drug.""?",False, +7204638,Losartan causes Left ventricular hypertrophy,3390,The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.,"Is the triple ""Losartan causes Left ventricular hypertrophy"" supported by the sentence: ""The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats.""?",False, +26608778,Losartan affects essential hypertension,3391,The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.,"Is the triple ""Losartan affects essential hypertension"" supported by the sentence: ""The present study evaluates the hemodynamic and humoral effects of losartan in essential hypertension.""?",False, +24425437,Losartan affects cystic fibrosis,3392,Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.,"Is the triple ""Losartan affects cystic fibrosis"" supported by the sentence: ""Losartan ameliorates TGF-beta1-induced CFTR dysfunction and improves correction by cystic fibrosis modulator therapies.""?",False, +21888728,Losartan affects proteinuria,3393,"Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Selective antagonism of the endothelin-1 receptor, ET A R, by atrasentan treatment in combination with RAAS inhibition with losartan has been shown to have the therapeutic benefit of lowering proteinuria in patients with diabetic nephropathy, but the underlying mechanism for this benefit is not well understood.""?",False, +20488125,Losartan affects hypertensive disorder,3394,"The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.","Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""The AT1R blocker, Losartan, normalized elevated blood pressure and markedly improved glomerular filtration in the shGRK2 knockdown mice.""?",False, +19990804,Losartan affects aortic valve insufficiency,3395,Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.,"Is the triple ""Losartan affects aortic valve insufficiency"" supported by the sentence: ""Losartan and metoprolol have significantly different short-term effects on aortic regurgitation and LV and aortic function in chronic AR.""?",False, +18707849,Losartan affects hypertrophic cardiomyopathy,3396,Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.,"Is the triple ""Losartan affects hypertrophic cardiomyopathy"" supported by the sentence: ""Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.""?",False, +16976701,Losartan affects IgA glomerulonephritis,3397,CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.,"Is the triple ""Losartan affects IgA glomerulonephritis"" supported by the sentence: ""CONCLUSION: Losartan treatment can delay the progression of advanced IgA nephropathy with impaired renal function.""?",False, +13986638,Losartan affects adult acute respiratory distress syndrome,3398,This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.,"Is the triple ""Losartan affects adult acute respiratory distress syndrome"" supported by the sentence: ""This study evaluates the effects of losartan on ALI/ARDS and further investigates the possible mechanisms of these protective effects.""?",False, +13539739,Losartan affects proteinuria,3399,"Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.","Is the triple ""Losartan affects proteinuria"" supported by the sentence: ""Exercise, exercise and losartan, and losartan blunted the increases in proteinuria.""?",False, +13498248,Losartan affects Inflammation,3400,"Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.","Is the triple ""Losartan affects Inflammation"" supported by the sentence: ""Thus, the suppressive effect of losartan on ocular inflammation in EIU appeared to result from down-regulation of NF-kappaB activation and reduction of inflammatory cytokine production.""?",False, +12531070,Losartan affects Left ventricular hypertrophy,3401,Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.,"Is the triple ""Losartan affects Left ventricular hypertrophy"" supported by the sentence: ""Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients.""?",False, +10809955,Losartan affects hypertensive disorder,3402,Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).,"Is the triple ""Losartan affects hypertensive disorder"" supported by the sentence: ""Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01).""?",False, +9615315,Losartan affects diabetic kidney disease,3403,Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?,"Is the triple ""Losartan affects diabetic kidney disease"" supported by the sentence: ""Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?""?",False, +9459571,Losartan affects type 2 diabetes mellitus,3404,CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: These data demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.""?",False, +9229634,Losartan affects kidney disorder,3405,Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.,"Is the triple ""Losartan affects kidney disorder"" supported by the sentence: ""Our data suggest a beneficial effect of losartan in STZ-induced nephropathy in rats.""?",False, +8678480,Losartan affects injury,3406,"Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.","Is the triple ""Losartan affects injury"" supported by the sentence: ""Losartan completely blocked the Ang II-mediated hypertension, proteinuria, and injury to both carotid and kidney.""?",False, +8551167,Losartan affects type 2 diabetes mellitus,3407,METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.,"Is the triple ""Losartan affects type 2 diabetes mellitus"" supported by the sentence: ""METHODS: The influence of losartan (50 mg daily for four weeks) on endothelium-dependent and independent vasodilator function was determined in 9 NIDDM subjects using a double-blinded placebo-controlled crossover protocol.""?",False, +18715311,Losartan disrupts breast neoplasm,3408,"In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.","Is the triple ""Losartan disrupts breast neoplasm"" supported by the sentence: ""In combination, losartan combined with DOX-AuNPs-GNPs showed the best drug delivery efficiency, striking penetration efficiency and best 4T1 breast tumor inhibition effect.""?",False, +14458903,Losartan disrupts pancreatic neoplasm,3409,"When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.","Is the triple ""Losartan disrupts pancreatic neoplasm"" supported by the sentence: ""When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development.""?",False, +13976332,Losartan disrupts diabetic kidney disease,3410,OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.,"Is the triple ""Losartan disrupts diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the degradation mechanism of losartan on extracellular matrix in rats with diabetic nephropathy.""?",False, +12949848,Losartan disrupts Inflammation,3411,"Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.","Is the triple ""Losartan disrupts Inflammation"" supported by the sentence: ""Compared with simvastatin, losartan had less effect on suppression of CRP-mediated inflammation.""?",False, +9870082,Losartan disrupts hypertensive disorder,3412,Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).,"Is the triple ""Losartan disrupts hypertensive disorder"" supported by the sentence: ""Crumbling of left ventricular hypertrophy as a surrogate end point (the Losartan for Intervention for Endpoint Reduction in Hypertension [LIFE] Study).""?",False, +9655766,Losartan disrupts type 2 diabetes mellitus,3413,"Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.","Is the triple ""Losartan disrupts type 2 diabetes mellitus"" supported by the sentence: ""Indeed, in the recently published landmark trials of angiotensin I receptor antagonists, including the Irbesartan Diabetic Nephropathy Trial (IDNT) and Reduction of Endpoints in Non-insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL), multiple antihypertensive drugs were required to attain goal.""?",False, +8325352,Losartan disrupts Left ventricular hypertrophy,3414,"Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.","Is the triple ""Losartan disrupts Left ventricular hypertrophy"" supported by the sentence: ""Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan.""?",False, +7975855,Losartan disrupts injury,3415,Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.,"Is the triple ""Losartan disrupts injury"" supported by the sentence: ""Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney.""?",False, +7310299,Losartan disrupts proteinuria,3416,"CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.","Is the triple ""Losartan disrupts proteinuria"" supported by the sentence: ""CEI and LOS as monotherapy significantly reduced proteinuria by 38% and 30%, respectively.""?",False, +21356716,Losartan prevents post-traumatic stress disorder,3417,"We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.","Is the triple ""Losartan prevents post-traumatic stress disorder"" supported by the sentence: ""We discuss potential mechanisms of losartan in preventing PTSD symptomatology, including the role of reduced arousal and increased contextual processing during trauma exposure, as well as increased threat-safety differentiation when encountering peripheral trauma-cues in the aftermaths of traumatic events.""?",False, +14540327,Losartan prevents kidney disorder,3418,BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.,"Is the triple ""Losartan prevents kidney disorder"" supported by the sentence: ""BACKGROUND: The study RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) demonstrated that Losartan was more effective lo reduce the progression of kidney disease in diabetic patients with proteinuria and a reduction in glomerular filtration rate.""?",False, +12407992,Losartan prevents Inflammation,3419,"RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.","Is the triple ""Losartan prevents Inflammation"" supported by the sentence: ""RESULTS: Losartan reduced the inflammation induced by bleomycin, as indicated by lower myeloperoxidase activity and protein content in the bronchoalveolar lavage fluid.""?",False, +10030687,Losartan prevents cardiovascular disorder,3420,Losartan vs atenolol in prevention of stroke and cardiovascular disease.,"Is the triple ""Losartan prevents cardiovascular disorder"" supported by the sentence: ""Losartan vs atenolol in prevention of stroke and cardiovascular disease.""?",False, +9856661,Losartan prevents diabetic kidney disease,3421,This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.,"Is the triple ""Losartan prevents diabetic kidney disease"" supported by the sentence: ""This evidence is based on recent studies showing that losartan and irbesartan can prevent the development of overt diabetic nephropathy in microalbuminuric type 2 diabetic patients as well as slow the velocity of progression to end-stage renal disease in patients with overt type 2 diabetic nephropathy.""?",False, +9773800,Losartan prevents Left ventricular hypertrophy,3422,Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.,"Is the triple ""Losartan prevents Left ventricular hypertrophy"" supported by the sentence: ""Losartan decreased ECG-LVH more than atenolol (P<.001) and was better tolerated.""?",False, +9766007,Losartan prevents adult acute respiratory distress syndrome,3423,"Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.","Is the triple ""Losartan prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Herein, we analyze whether losartan would prevent the development of the acute respiratory distress syndrome (ARDS) triggered by lung bacterial infection.""?",False, +9420091,Losartan prevents Stenosis,3424,The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.,"Is the triple ""Losartan prevents Stenosis"" supported by the sentence: ""The results also suggest that collagen accumulation in the intima may be an important factor in the development of the stenotic lesion and that the use of losartan may have therapeutic value to prevent stenosis after balloon injury.""?",False, +9077908,Losartan prevents proteinuria,3425,"Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.","Is the triple ""Losartan prevents proteinuria"" supported by the sentence: ""Combined treatment with MMF and losartan completely prevented the development of proteinuria, largely reduced glomerular and tubulointerstitial injury, and suppressed intragraft cell infiltration, and all animals survived at the end of the follow-up.""?",False, +8542944,Losartan prevents injury,3426,Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.,"Is the triple ""Losartan prevents injury"" supported by the sentence: ""Histological evaluation of lungs as well as the analysis of lung hemorrhage indices showed that losartan prevents tissue injury partially in fMLP-challenged rats.""?",False, +7768196,Losartan prevents hypertensive disorder,3427,"RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.","Is the triple ""Losartan prevents hypertensive disorder"" supported by the sentence: ""RESULTS: Losartan therapy prevented the development of L-NAME-induced hypertension and the associated impairments of endothelium-independent relaxations to nitroprusside, isoprenaline, and cromakalim, vasodilators acting via the formation of NO, activation of beta-adrenoceptors and opening of K+ channels, respectively.""?",False, +14272023,Losartan predisposes kidney disorder,3428,"Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.","Is the triple ""Losartan predisposes kidney disorder"" supported by the sentence: ""Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression.""?",False, +12616336,Losartan predisposes cardiovascular disorder,3429,"Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.","Is the triple ""Losartan predisposes cardiovascular disorder"" supported by the sentence: ""Although some of these effects may be shared by other angiotensin II receptor antagonists (AIIAs), and perhaps other anti-hypertensive classes (eg, angiotensin-converting enzyme inhibitors), the ability of losartan to lower serum uric acid levels-a proposed independent risk factor for cardiovascular disease-appears to be a molecule-specific effect.""?",False, +9964252,Losartan predisposes Left ventricular hypertrophy,3430,"In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).","Is the triple ""Losartan predisposes Left ventricular hypertrophy"" supported by the sentence: ""In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH).""?",False, +20586471,Dronabinol related to multiple sclerosis,3431,A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.,"Is the triple ""Dronabinol related to multiple sclerosis"" supported by the sentence: ""A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.""?",False, +25459397,Dronabinol causes cannabis dependence,3432,"BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.","Is the triple ""Dronabinol causes cannabis dependence"" supported by the sentence: ""BACKGROUND: Global rise in cannabis abuse during reproductive years has placed a large number of men at risk for the adverse consequences of delta-9-tetrahydrocannabinol (THC), the primary active component of cannabis.""?",False, +22027243,Dronabinol causes Nausea,3433,"CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.","Is the triple ""Dronabinol causes Nausea"" supported by the sentence: ""CONCLUSIONS: Treatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.""?",False, +17252204,Dronabinol causes schizophrenia,3434,"Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.","Is the triple ""Dronabinol causes schizophrenia"" supported by the sentence: ""Moreover, since cortical disinhibition seems to be a key feature of many different animal models of schizophrenia and GABAergic hypofunction in the prefrontal cortex (PFC) has been observed in postmortem brains from schizophrenic patients, we then investigated the long-lasting consequences of adolescent THC exposure on GABAergic transmission in the adult rat PFC.""?",False, +12205989,Dronabinol causes Cognitive impairment,3435,"Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.","Is the triple ""Dronabinol causes Cognitive impairment"" supported by the sentence: ""Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown.""?",False, +27448088,Dronabinol affects Anorexia,3436,Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.,"Is the triple ""Dronabinol affects Anorexia"" supported by the sentence: ""Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.""?",False, +25890458,Dronabinol affects Nausea,3437,"Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.","Is the triple ""Dronabinol affects Nausea"" supported by the sentence: ""Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.""?",False, +21879717,Dronabinol affects anorexia nervosa,3438,"The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.","Is the triple ""Dronabinol affects anorexia nervosa"" supported by the sentence: ""The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Delta9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events.""?",False, +20855895,Dronabinol affects neoplasm,3439,"Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.","Is the triple ""Dronabinol affects neoplasm"" supported by the sentence: ""Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors.""?",False, +19991701,Dronabinol affects obstructive sleep apnea syndrome,3440,"Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.","Is the triple ""Dronabinol affects obstructive sleep apnea syndrome"" supported by the sentence: ""Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea.""?",False, +19474044,Dronabinol affects multiple sclerosis,3441,Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.,"Is the triple ""Dronabinol affects multiple sclerosis"" supported by the sentence: ""Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Delta9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.""?",False, +16547908,Dronabinol affects schizophrenia,3442,"CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""CONCLUSIONS: At plasma concentrations resembling recreational use, THC elicited schizophrenia-like negative symptoms which were not merely attributable to sedation.""?",False, +14443952,Dronabinol affects opiate dependence,3443,Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.,"Is the triple ""Dronabinol affects opiate dependence"" supported by the sentence: ""Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.""?",False, +13958866,Dronabinol affects Cognitive impairment,3444,"Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.","Is the triple ""Dronabinol affects Cognitive impairment"" supported by the sentence: ""Moreover, we evaluated the ability of the main psychoactive ingredient of marijuana, Delta9-tetrahydrocannabinol (THC), to modulate the cognitive dysfunctions and neuroadaptations in the endocannabinoid system induced by PCP.""?",False, +13933776,Dronabinol affects schizophrenia,3445,"This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.","Is the triple ""Dronabinol affects schizophrenia"" supported by the sentence: ""This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.""?",False, +11304843,Dronabinol affects neuralgia,3446,OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.,"Is the triple ""Dronabinol affects neuralgia"" supported by the sentence: ""OBJECTIVE: To evaluate the effect of the oral synthetic delta-9-tetrahydrocannabinol dronabinol on central neuropathic pain in patients with multiple sclerosis.""?",False, +11058493,Dronabinol affects Pain,3447,"THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.","Is the triple ""Dronabinol affects Pain"" supported by the sentence: ""THC (mean dosage: 16.6+/-6.5 mg/day) did not induce any significant effects on ongoing and paroxysmal pain, allodynia, quality of life, anxiety/depression scores and functional impact of pain.""?",False, +24013541,Dronabinol disrupts Pain,3448,"Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.","Is the triple ""Dronabinol disrupts Pain"" supported by the sentence: ""Conclusion: Although THC and THC/CBD interventions provided a significant improvement in pain intensity and were more likely to provide a 30% reduction in pain, the evidence was of moderate-to-low quality.""?",False, +17477155,Dronabinol disrupts HIV infectious disease,3449,"Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.","Is the triple ""Dronabinol disrupts HIV infectious disease"" supported by the sentence: ""Ultimately, the mechanism of THC suppression of HIV-1 infection was traced to a reduction in cell surface HIV receptor (CD4, CCR5 and CXCR4) expression that diminished entry efficiency.""?",False, +11615857,Dronabinol disrupts Nausea,3450,"The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.","Is the triple ""Dronabinol disrupts Nausea"" supported by the sentence: ""The principal psychoactive component of marijuana, delta-9-tetrahydrocannabinol (Delta9-THC), suppresses nausea and vomiting in cancer patients caused by chemotherapeutics such as cisplatin.""?",False, +25196408,Dronabinol prevents dementia,3451,Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.,"Is the triple ""Dronabinol prevents dementia"" supported by the sentence: ""Emerging evidence suggests that CBD and tetrahydrocannabinol have neuroprotective therapeutic-like effects on dementias.""?",False, +25026370,Dronabinol prevents neuralgia,3452,We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.,"Is the triple ""Dronabinol prevents neuralgia"" supported by the sentence: ""We also found that high THC extract or pure THC is the most efficacious treatment for reducing neuropathic pain in this model.""?",False, +18579580,Dronabinol prevents Postoperative Nausea and Vomiting,3453,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, +18554637,Dronabinol prevents Nausea,3454,"However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.","Is the triple ""Dronabinol prevents Nausea"" supported by the sentence: ""However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 MUg/kg) alone, as well as these combined doses, also reduced anticipatory nausea.""?",False, +17477149,Dronabinol prevents HIV infectious disease,3455,THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.,"Is the triple ""Dronabinol prevents HIV infectious disease"" supported by the sentence: ""THC treatment of primary human monocytes during differentiation reduced HIV-1 infection of subsequent macrophages by replication competent or single cycle CCR5 using viruses.""?",False, +9671016,Dronabinol prevents Pain,3456,"There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.","Is the triple ""Dronabinol prevents Pain"" supported by the sentence: ""There is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-THC), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances.""?",False, +22976957,Dronabinol predisposes Cognitive impairment,3457,"The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.","Is the triple ""Dronabinol predisposes Cognitive impairment"" supported by the sentence: ""The long-term effects of these changes require more rigorous investigation, though early reports suggest Delta9-THC increases the risk of cognitive impairment and neuropsychiatric disease, including psychosis, depression, anxiety, and sleep disorders.""?",False, +18579581,Dronabinol predisposes Postoperative Nausea and Vomiting,3458,"To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.","Is the triple ""Dronabinol predisposes Postoperative Nausea and Vomiting"" supported by the sentence: ""To evaluate the effectiveness of IV THC in the prevention of PONV, we performed this double-blind, randomized, placebo-controlled trial with patient stratification according to the risk of PONV.""?",False, +26722658,Cesamet affects Postoperative Nausea and Vomiting,3459,"In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).","Is the triple ""Cesamet affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV).""?",False, +26699974,Cesamet affects Nausea,3460,Effect of nabilone on nausea and vomiting.,"Is the triple ""Cesamet affects Nausea"" supported by the sentence: ""Effect of nabilone on nausea and vomiting.""?",False, +19460580,Cesamet prevents Postoperative Nausea and Vomiting,3461,METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.,"Is the triple ""Cesamet prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""METHODS: This was a pragmatic single-centre randomized-controlled trial comparing oral nabilone vs placebo for the prevention of PONV.""?",False, +25552574,Aprepitant related to glioblastoma,3462,"The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.","Is the triple ""Aprepitant related to glioblastoma"" supported by the sentence: ""The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma.""?",False, +18054447,Aprepitant related to Vomiting,3463,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Vomiting"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, +18054446,Aprepitant related to Nausea,3464,"In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.","Is the triple ""Aprepitant related to Nausea"" supported by the sentence: ""In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting.""?",False, +11788538,Aprepitant causes Vomiting,3465,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Vomiting"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, +11788537,Aprepitant causes Nausea,3466,Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.,"Is the triple ""Aprepitant causes Nausea"" supported by the sentence: ""Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents.""?",False, +23692862,Aprepitant affects Nausea,3467,"The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.","Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""The addition of aprepitant in combination with cisplatin did not allow increasing the dose due to hematological toxicity, whereas omitting aprepitant increased the incidence of nausea and vomiting.""?",False, +19750085,Aprepitant affects Postoperative Nausea and Vomiting,3468,"In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.","Is the triple ""Aprepitant affects Postoperative Nausea and Vomiting"" supported by the sentence: ""In this subset, OR estimates quantifying aprepitant effect on PONV were similar to those obtained from multivariable regression analyses.""?",False, +17874842,Aprepitant affects Vomiting,3469,"Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.","Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Absence of major nausea (94% v 88%; OR, 2.37; 95% CI, 1.09 to 5.15; P = .026) and emesis (78% v 65%; OR, 1.99; 95% CI, 1.25 to 3.18; P = .0036) within 120 hours was increased by aprepitant.""?",False, +12562288,Aprepitant affects Nausea,3470,Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.,"Is the triple ""Aprepitant affects Nausea"" supported by the sentence: ""Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens.""?",False, +11119543,Aprepitant affects Vomiting,3471,Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.,"Is the triple ""Aprepitant affects Vomiting"" supported by the sentence: ""Aprepitant is an oral neurokinin-1 receptor antagonist which acts centrally to block chemotherapy-induced emesis.""?",False, +19013645,Aprepitant disrupts HIV infectious disease,3472,RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.,"Is the triple ""Aprepitant disrupts HIV infectious disease"" supported by the sentence: ""RESULTS: Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50 ~ 5 uM.""?",False, +16125731,Aprepitant disrupts Vomiting,3473,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Vomiting"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, +16125730,Aprepitant disrupts Nausea,3474,These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.,"Is the triple ""Aprepitant disrupts Nausea"" supported by the sentence: ""These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.""?",False, +16513148,Aprepitant prevents Pruritus,3475,"INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.","Is the triple ""Aprepitant prevents Pruritus"" supported by the sentence: ""INTERPRETATION: Aprepitant decreases severe pruritus induced by biological treatments; it is an old drug, widely available, and therefore easy to add to the armamentarium of supportive treatment.""?",False, +15868137,Aprepitant prevents Postoperative Nausea and Vomiting,3476,We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.,"Is the triple ""Aprepitant prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery.""?",False, +10160541,Aprepitant prevents Vomiting,3477,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Vomiting"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, +10160540,Aprepitant prevents Nausea,3478,"BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.","Is the triple ""Aprepitant prevents Nausea"" supported by the sentence: ""BACKGROUND: The neurokinin-1 antagonist aprepitant (EMEND; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapy-induced nausea and vomiting when it is given with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.""?",False, +20804596,Aprepitant predisposes Nausea,3479,"CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.","Is the triple ""Aprepitant predisposes Nausea"" supported by the sentence: ""CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.""?",False, +22122089,Neratinib affects neoplasm,3480,The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].,"Is the triple ""Neratinib affects neoplasm"" supported by the sentence: ""The irreversible ERBB receptor family and MAP4K inhibitor neratinib significantly enhanced the anti-tumor efficacy of [sorafenib + vorinostat].""?",False, +21597229,Lapatinib related to neoplasm,3481,"Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.","Is the triple ""Lapatinib related to neoplasm"" supported by the sentence: ""Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines.""?",False, +13650844,Lapatinib related to non-small cell lung carcinoma,3482,"In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.","Is the triple ""Lapatinib related to non-small cell lung carcinoma"" supported by the sentence: ""In this study, we show that a combination of lapatinib and cetuximab overcomes gefitinib resistance in NSCLC with the T790M mutation.""?",False, +18268107,Lapatinib affects neoplasm,3483,Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.,"Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer.""?",False, +15442238,Lapatinib affects breast neoplasm,3484,HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.,"Is the triple ""Lapatinib affects breast neoplasm"" supported by the sentence: ""HER-2/neu predicts the sensitivity of breast tumors to trastuzumab and lapatinib.""?",False, +14691634,Lapatinib affects neoplasm,3485,"However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.","Is the triple ""Lapatinib affects neoplasm"" supported by the sentence: ""However, lapatinib synergized with the anti-tumor activity of the S-1 components 5-fluorouracil and 5-chloro-2,4-dihydrogenase against all cell lines.""?",False, +17546445,Lapatinib disrupts neoplasm,3486,"Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.","Is the triple ""Lapatinib disrupts neoplasm"" supported by the sentence: ""Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays.""?",False, +19410918,Lapatinib prevents breast neoplasm,3487,"Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.","Is the triple ""Lapatinib prevents breast neoplasm"" supported by the sentence: ""Then, we tested the efficacy of brief exposure to lapatinib (100 mg/kg/day for 8 weeks), beginning at 16 weeks of age, in the prevention of mammary tumor development in MMTV-erbB-2 mice.""?",False, +19317295,Lapatinib prevents neoplasm,3488,CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.,"Is the triple ""Lapatinib prevents neoplasm"" supported by the sentence: ""CONCLUSIONS: Short-term lapatinib resulted in a cSCC tumour reduction in 2 of 8 patients.""?",False, +16643911,Lapatinib predisposes neoplasm,3489,"We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.","Is the triple ""Lapatinib predisposes neoplasm"" supported by the sentence: ""We evaluated both immune and nonimmune effects of cetuximab (anti-ERBB1 Mab), trastuzumab (anti-ERBB2 Mab), pertuzumab (anti-ERBB2 Mab), and lapatinib (dual ERBB1 and ERBB2 tyrosine kinase inhibitor) in a large well-characterized panel of 64 CRC cell lines to find response predictive tumor characteristics.""?",False, +24360220,Nifurtimox related to human African trypanosomiasis,3490,Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.,"Is the triple ""Nifurtimox related to human African trypanosomiasis"" supported by the sentence: ""Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT.""?",False, +25977066,Nifurtimox coexists with Deoxyribonucleic acid,3491,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, +25977066,Nifurtimox coexists with Deoxyribonucleic acid,3492,"Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.","Is the triple ""Nifurtimox coexists with Deoxyribonucleic acid"" supported by the sentence: ""Taking into account the effects of nifurtimox and beta-lapachone on DNA stability, specific lesions (single-strand breaks) were investigated in DNA from control, nifurtimox, benznidazole or beta-lapachone treated epimastigotes.""?",False, +25822629,Nifurtimox causes Chagas disease,3493,Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.,"Is the triple ""Nifurtimox causes Chagas disease"" supported by the sentence: ""Ultrastructural observations on the activity of nifurtimox on the causative organism of Chagas' disease.""?",False, +21140520,Nifurtimox affects neuroblastoma,3494,"Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.","Is the triple ""Nifurtimox affects neuroblastoma"" supported by the sentence: ""Importantly, as comparing to temozolomide, nifurtimox presented a stronger effect on inhibiting tumor development, strongly suggesting that nifurtimox is a preferential alternative drug in treating neuroblastoma.""?",False, +19390598,Nifurtimox affects trypanosomiasis,3495,"The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.","Is the triple ""Nifurtimox affects trypanosomiasis"" supported by the sentence: ""The present work was designed to fill this gap and evaluate the effect of NTZ on experimental murine trypanosomiasis, in comparison with classical antichagasic agent NFT.""?",False, +18236131,Nifurtimox affects Deoxyribonucleic acid,3496,"Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).","Is the triple ""Nifurtimox affects Deoxyribonucleic acid"" supported by the sentence: ""Nifurtimox and benznidazole, two nitroheterocyclic drugs, inhibited DNA, RNA and protein synthesis, stimulated macromolecular degradation, and stimulated unscheduled DNA synthesis in Trypanosoma cruzi (Tulahuen strain).""?",False, +21140519,Nifurtimox disrupts neuroblastoma,3497,"Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.","Is the triple ""Nifurtimox disrupts neuroblastoma"" supported by the sentence: ""Here we exhibited that nifurtimox could suppress the progression of neuroblastoma in vivo, while maintain the health condition to a great extent.""?",False, +16729888,Nifurtimox prevents Chagas disease,3498,"Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.","Is the triple ""Nifurtimox prevents Chagas disease"" supported by the sentence: ""Timely antiparasitic treatment with benznidazole and nifurtimox (or with posaconazole in cases of therapeutic failure) has proven to be highly effective in preventing Chagas disease reactivation, even if such treatment has not been formally incorporated into management protocols for immunosuppressed patients.""?",False, +8359719,Nitrofurazone coexists with Deoxyribonucleic acid,3499,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, +8359719,Nitrofurazone coexists with Deoxyribonucleic acid,3500,The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.,"Is the triple ""Nitrofurazone coexists with Deoxyribonucleic acid"" supported by the sentence: ""The S. typhimurium strains contain the reductase required for metabolic activation of the nitrofurans and treatment of a uvr+ S. typhimurium strain with niridazole or with nitrofurazone causes single-strand breaks in DNA.""?",False, +21506050,Nitrofurazone physically interacts with Deoxyribonucleic acid,3501,"Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""Depicting the binding of furazolidone/furacilin with DNA by multiple spectroscopies, voltammetric as well as molecular docking.The interaction between DNA and furazolidone/furacillin was investigated using various analytical techniques including spectroscopy and electroanalysis and molecular modelling.""?",False, +16350865,Nitrofurazone physically interacts with Deoxyribonucleic acid,3502,"In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.","Is the triple ""Nitrofurazone physically interacts with Deoxyribonucleic acid"" supported by the sentence: ""In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA.""?",False, +26982963,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3503,The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The purpose of this study was to examine the effects of scopolamine on the physiological patterns occurring prior to and during motion sickness stimulation.""?",False, +14891197,SCOPOLAMINE HYDROBROMIDE affects Pain,3504,Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Pain"" supported by the sentence: ""Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity.""?",False, +13216168,SCOPOLAMINE HYDROBROMIDE affects motion sickness,3505,The effects of scopolamine on MS were studied in mice and rats.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE affects motion sickness"" supported by the sentence: ""The effects of scopolamine on MS were studied in mice and rats.""?",False, +9844335,SCOPOLAMINE HYDROBROMIDE affects Drooling,3506,"CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.","Is the triple ""SCOPOLAMINE HYDROBROMIDE affects Drooling"" supported by the sentence: ""CONCLUSIONS: Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea.""?",False, +11447618,SCOPOLAMINE HYDROBROMIDE prevents Pain,3507,In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Pain"" supported by the sentence: ""In a prospective randomized double-blind study among 50 males undergoing surgery we evaluated the possible role of transdermally applied scopolamine (Scopoderm) in the prevention of post open prostatectomy bladder contraction and pain.""?",False, +11253841,SCOPOLAMINE HYDROBROMIDE prevents Drooling,3508,"Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.","Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents Drooling"" supported by the sentence: ""Anticholinergic medications, such as glycopyrrolate and scopolamine, are effective in reducing drooling, but their use may be limited by side effects.""?",False, +8806634,SCOPOLAMINE HYDROBROMIDE prevents motion sickness,3509,Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.,"Is the triple ""SCOPOLAMINE HYDROBROMIDE prevents motion sickness"" supported by the sentence: ""Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes.""?",False, +26997768,Metopimazine affects Nausea,3510,"RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.","Is the triple ""Metopimazine affects Nausea"" supported by the sentence: ""RESULTS: Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone.""?",False, +12265728,Metopimazine prevents Nausea,3511,"This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.","Is the triple ""Metopimazine prevents Nausea"" supported by the sentence: ""This randomized, double-blind, double-dummy, multicenter study was designed to compare the efficacy and tolerance of metopimazine and ondansetron at preventing nausea and emesis in patients receiving chemotherapy.""?",False, +27200379,Lincomycin related to osteomyelitis,3512,[Optimal regime of intravenous administration of lincomycin in osteomyelitis].,"Is the triple ""Lincomycin related to osteomyelitis"" supported by the sentence: ""[Optimal regime of intravenous administration of lincomycin in osteomyelitis].""?",False, +9905527,Sulindac causes classic familial adenomatous polyposis,3513,"CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.","Is the triple ""Sulindac causes classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: APC overexpression induced by sulindac can suppress colon carcinogenesis at both the early and late stages, but apoptosis might work as one of anti-cancer mechanisms at the early stage of colon carcinogenesis.""?",False, +9905522,Sulindac affects classic familial adenomatous polyposis,3514,Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.""?",False, +8547552,Sulindac affects classic familial adenomatous polyposis,3515,CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.,"Is the triple ""Sulindac affects classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Both sulindac and etodolac reduced the occurrence of ACF and induced an increase in APC mRNA in rat colon mucosa.""?",False, +11060423,Sulindac prevents classic familial adenomatous polyposis,3516,"CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.","Is the triple ""Sulindac prevents classic familial adenomatous polyposis"" supported by the sentence: ""CONCLUSIONS: Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.""?",False, +20876966,Ketorolac related to migraine disorder,3517,"Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.","Is the triple ""Ketorolac related to migraine disorder"" supported by the sentence: ""Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial.""?",False, +27688883,Ketorolac causes Inflammation,3518,We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.,"Is the triple ""Ketorolac causes Inflammation"" supported by the sentence: ""We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.""?",False, +21368479,Ketorolac causes pancreatitis,3519,Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.,"Is the triple ""Ketorolac causes pancreatitis"" supported by the sentence: ""Intranasal ketorolac-induced pancreatitis as a complication of modified oral aspirin desensitization in a patient with aspirin-exacerbated respiratory disease.""?",False, +19597016,Ketorolac causes Miosis,3520,CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.,"Is the triple ""Ketorolac causes Miosis"" supported by the sentence: ""CONCLUSIONS: Short-term topical use of ketorolac prior to femtosecond laser-assisted cataract surgery seems to induce significantly less pupillary miosis in comparison to eyes that did not receive NSAID pretreatment.""?",False, +12090892,Ketorolac causes Pain,3521,"However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.","Is the triple ""Ketorolac causes Pain"" supported by the sentence: ""However, as the study progressed it became apparent that the intra-oral injection of ketorolac caused significant pain to four of the five patients who received it; therefore the study was terminated after ten patients had been treated.""?",False, +20018980,Ketorolac affects breast neoplasm,3522,The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.,"Is the triple ""Ketorolac affects breast neoplasm"" supported by the sentence: ""The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.""?",False, +19245410,Ketorolac affects Miosis,3523,"Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.","Is the triple ""Ketorolac affects Miosis"" supported by the sentence: ""Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac, which inhibit the synthesis of prostaglandins, are used to decrease intraoperative miosis, control pain and inflammation associated with cataract surgery, and to prevent the development of cystoid macular edema following surgery.""?",False, +9719257,Ketorolac affects Pain,3524,Effect of pretreatment with ketorolac on propofol injection pain.,"Is the triple ""Ketorolac affects Pain"" supported by the sentence: ""Effect of pretreatment with ketorolac on propofol injection pain.""?",False, +24071071,Ketorolac disrupts Headache,3525,CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.,"Is the triple ""Ketorolac disrupts Headache"" supported by the sentence: ""CONCLUSION: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches.""?",False, +24029444,Ketorolac disrupts Inflammation,3526,"Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.","Is the triple ""Ketorolac disrupts Inflammation"" supported by the sentence: ""Thus, unlike dexamethasone, ketorolac seems to be a drug that can suppress inflammation without exacerbating fungal ocular infection.""?",False, +11549492,Ketorolac disrupts Pain,3527,Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.,"Is the triple ""Ketorolac disrupts Pain"" supported by the sentence: ""Locally administered intraoperative ketorolac and bupivacaine with epinephrine significantly reduced pain in the postoperative period.""?",False, +11362008,Ketorolac disrupts Back pain,3528,"Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.","Is the triple ""Ketorolac disrupts Back pain"" supported by the sentence: ""Based on these findings it can be recommended that intradermal ketorolac given at the time of epidural catheter placement may result in a reduction in post-epidural back pain in the parturient, especially in the event of cesarean delivery.""?",False, +24306825,Ketorolac prevents Renal Colic,3529,"Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.","Is the triple ""Ketorolac prevents Renal Colic"" supported by the sentence: ""Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department: A randomized, double-blind clinical trial.""?",False, +23612322,Ketorolac prevents Chronic pain,3530,"A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.","Is the triple ""Ketorolac prevents Chronic pain"" supported by the sentence: ""A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total intravenous anesthetic, paravertebral nerve blocks, dexmedetomidine, and ketorolac, as well as the role each of these plays in the prevention of chronic pain and cancer recurrence is provided.""?",False, +20717559,Ketorolac prevents injury,3531,There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.,"Is the triple ""Ketorolac prevents injury"" supported by the sentence: ""There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.""?",False, +11362007,Ketorolac prevents Back pain,3532,Intradermal ketorolac for reduction of epidural back pain.,"Is the triple ""Ketorolac prevents Back pain"" supported by the sentence: ""Intradermal ketorolac for reduction of epidural back pain.""?",False, +11361661,Ketorolac prevents Inflammation,3533,CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.,"Is the triple ""Ketorolac prevents Inflammation"" supported by the sentence: ""CONCLUSIONS: Topical application of ketorolac concentrations as low as 0.01%-0.1% significantly reduce chemically induced ocular inflammation in rabbits.""?",False, +11043378,Ketorolac prevents Headache,3534,"At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).","Is the triple ""Ketorolac prevents Headache"" supported by the sentence: ""At one hour, ketorolac was significantly less effective than meperidine in reducing headache pain (P = .02) and in improving clinical disability (P = .01).""?",False, +7985904,Ketorolac prevents Pain,3535,Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.,"Is the triple ""Ketorolac prevents Pain"" supported by the sentence: ""Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.""?",False, +20028754,Ketorolac predisposes injury,3536,"The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.","Is the triple ""Ketorolac predisposes injury"" supported by the sentence: ""The results also suggested that increased risk of AKI was likely associated with the concomitant use of valacyclovir and some NSAIDs such as loxoprofen, diclofenac, etodolac, ketorolac, piroxicam or lornoxicam.""?",False, +25929768,Sulfadiazine related to congenital toxoplasmosis,3537,"[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].","Is the triple ""Sulfadiazine related to congenital toxoplasmosis"" supported by the sentence: ""[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].""?",False, +16546748,Sulfadiazine related to chorioretinitis,3538,"The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.","Is the triple ""Sulfadiazine related to chorioretinitis"" supported by the sentence: ""The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis.""?",False, +27660461,Sulfamethoxazole causes pneumonia,3539,"Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.","Is the triple ""Sulfamethoxazole causes pneumonia"" supported by the sentence: ""Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.""?",False, +24328685,Sulfamethoxazole causes kidney disorder,3540,"In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.","Is the triple ""Sulfamethoxazole causes kidney disorder"" supported by the sentence: ""In conclusion, In conclusion, these results suggest a protective effect of LYC dietary supplements against kidney damage caused by SMZ.""?",False, +14835537,Sulfamethoxazole affects cystic fibrosis,3541,The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).,"Is the triple ""Sulfamethoxazole affects cystic fibrosis"" supported by the sentence: ""The total plasma clearance of sulfamethoxazole was found to be increased in cystic fibrosis (0.0262 +/- 0.0064 L/hr/kg) when compared with that found in control subjects (0.0188 +/- 0.0043 L/hr/kg).""?",False, +12226918,Sulfamethoxazole affects ocular toxoplasmosis,3542,PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.,"Is the triple ""Sulfamethoxazole affects ocular toxoplasmosis"" supported by the sentence: ""PURPOSE: To evaluate the effects of sulfamethoxazole (SMX) on experimental ocular toxoplasmosis by quantitative competitive polymerase chain reaction (QC-PCR) assay.""?",False, +26634163,Sulfamethoxazole prevents bacterial infectious disease,3543,These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.,"Is the triple ""Sulfamethoxazole prevents bacterial infectious disease"" supported by the sentence: ""These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.""?",False, +23781290,Sulfamethoxazole prevents Infection,3544,"Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.","Is the triple ""Sulfamethoxazole prevents Infection"" supported by the sentence: ""Background: Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely used, in combination, to treat or prevent various infections.""?",False, +22185408,Sulfamethoxazole prevents pneumocystosis,3545,The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.,"Is the triple ""Sulfamethoxazole prevents pneumocystosis"" supported by the sentence: ""The safety and efficacy of sulfamethoxazole and trimethoprim in the prevention of Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome (AIDS) were evaluated.""?",False, +21716989,Glycyrrhizic acid affects osteoarthritis,3546,"However, it has not been reported whether glycyrrhizin has a positive effect on OA development.","Is the triple ""Glycyrrhizic acid affects osteoarthritis"" supported by the sentence: ""However, it has not been reported whether glycyrrhizin has a positive effect on OA development.""?",False, +21716987,Glycyrrhizic acid disrupts osteoarthritis,3547,Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.,"Is the triple ""Glycyrrhizic acid disrupts osteoarthritis"" supported by the sentence: ""Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-kappaB signaling pathway in vivo and in vitro.""?",False, +13246285,Ciclesonide related to perennial allergic rhinitis,3548,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to perennial allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, +13246284,Ciclesonide related to seasonal allergic rhinitis,3549,BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.,"Is the triple ""Ciclesonide related to seasonal allergic rhinitis"" supported by the sentence: ""BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration.""?",False, +10789097,Ciclesonide related to asthma,3550,[Safety and efficacy of inhaled ciclesonide in asthma].,"Is the triple ""Ciclesonide related to asthma"" supported by the sentence: ""[Safety and efficacy of inhaled ciclesonide in asthma].""?",False, +13334776,Ciclesonide causes asthma,3551,Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.,"Is the triple ""Ciclesonide causes asthma"" supported by the sentence: ""Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.""?",False, +13603690,Ciclesonide affects asthma,3552,Ciclesonide improves measures of small airway involvement in asthma.,"Is the triple ""Ciclesonide affects asthma"" supported by the sentence: ""Ciclesonide improves measures of small airway involvement in asthma.""?",False, +26135729,Flunisolide related to perennial allergic rhinitis,3553,Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.,"Is the triple ""Flunisolide related to perennial allergic rhinitis"" supported by the sentence: ""Beclomethasone dipropionate and flunisolide: an open-crossover comparative trial in perennial allergic rhinitis.""?",False, +16438918,Flunisolide related to rhinitis,3554,"Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.","Is the triple ""Flunisolide related to rhinitis"" supported by the sentence: ""Of these analogues, betamethasone 17-valerate, beclomethasone 17,21-dipropionate, budesonide, flunisolide and triamcinolone acetonide have been developed as aerosols for use in asthma and rhinitis with a great deal of success and very little detectable systemic activity.""?",False, +7778368,Flunisolide related to asthma,3555,"Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.","Is the triple ""Flunisolide related to asthma"" supported by the sentence: ""Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.""?",False, +12189287,Flunisolide prevents Nasal congestion,3556,"The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.","Is the triple ""Flunisolide prevents Nasal congestion"" supported by the sentence: ""The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients.""?",False, +27725383,Etoposide related to hepatoblastoma,3557,"Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.","Is the triple ""Etoposide related to hepatoblastoma"" supported by the sentence: ""Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma.""?",False, +27360363,Etoposide related to ependymoma,3558,Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.,"Is the triple ""Etoposide related to ependymoma"" supported by the sentence: ""Daily oral etoposide is active in recurrent PNET/medulloblastoma and ependymoma.""?",False, +27062931,Etoposide related to supratentorial primitive neuroectodermal tumor,3559,Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.,"Is the triple ""Etoposide related to supratentorial primitive neuroectodermal tumor"" supported by the sentence: ""Carboplatin and etoposide with blood-brain barrier disruption is an active regimen in the treatment of malignant astrocytomas and has shown dramatic responses in primitive neuroectodermal tumors and CNS lymphoma.""?",False, +26965210,Etoposide related to kidney Wilms tumor,3560,"CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.","Is the triple ""Etoposide related to kidney Wilms tumor"" supported by the sentence: ""CONCLUSION: It is concluded that etoposide in this schedule is an active agent in Wilms' tumor and should be considered for inclusion in regimens for high-risk patients, such as those with metastatic disease at diagnosis and those who relapse after multiagent chemotherapy.""?",False, +26632944,Etoposide related to HIV infectious disease,3561,Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.,"Is the triple ""Etoposide related to HIV infectious disease"" supported by the sentence: ""Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS Clinical Trials Group.""?",False, +22727077,Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma,3562,"Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.","Is the triple ""Etoposide related to mature T-cell and NK-cell non-Hodgkin lymphoma"" supported by the sentence: ""Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas.""?",False, +21142004,Etoposide related to AIDS,3563,"The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.","Is the triple ""Etoposide related to AIDS"" supported by the sentence: ""The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used.In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors.We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.""?",False, +20988037,Etoposide related to retinoblastoma,3564,"The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.","Is the triple ""Etoposide related to retinoblastoma"" supported by the sentence: ""The results of this study suggest ICEV as an alternative therapeutic approach for globe salvage in pediatric retinoblastoma, especially in ICRB groups C and D with manageable acute toxicity.""?",False, +20394132,Etoposide related to B-cell neoplasm,3565,"Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.","Is the triple ""Etoposide related to B-cell neoplasm"" supported by the sentence: ""Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear.""?",False, +19900770,Etoposide related to myelodysplastic syndrome,3566,Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.,"Is the triple ""Etoposide related to myelodysplastic syndrome"" supported by the sentence: ""Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment.""?",False, +18768176,Etoposide related to hematopoietic and lymphoid system neoplasm,3567,"Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.","Is the triple ""Etoposide related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Trials of etoposide in hematologic malignancies, particularly leukemia and lymphoma, were initiated in 1973.""?",False, +17380085,Etoposide related to Kaposi's sarcoma,3568,"Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.","Is the triple ""Etoposide related to Kaposi's sarcoma"" supported by the sentence: ""Thus far, single-agent regimens using either vinblastine, vincristine, or etoposide have apparently shown the greatest efficacy in AIDS-associated Kaposi's sarcoma, with overall response rates of up to nearly 90% in some trials.""?",False, +17284305,Etoposide related to bone osteosarcoma,3569,We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.,"Is the triple ""Etoposide related to bone osteosarcoma"" supported by the sentence: ""We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma.""?",False, +17191209,Etoposide related to hepatocellular carcinoma,3570,The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).,"Is the triple ""Etoposide related to hepatocellular carcinoma"" supported by the sentence: ""The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).""?",False, +17136035,Etoposide related to diffuse large B-cell lymphoma,3571,"Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).","Is the triple ""Etoposide related to diffuse large B-cell lymphoma"" supported by the sentence: ""Infusional etoposide, prednisone, infusional vincristine, infusional doxorubicin, and cyclophosphamide (EPOCH) was associated with significantly better OS in diffuse large B-cell lymphoma (HR 0.33; P = .03).""?",False, +16406847,Etoposide related to neuroendocrine carcinoma,3572,"However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.","Is the triple ""Etoposide related to neuroendocrine carcinoma"" supported by the sentence: ""However, evidence for cisplatin/etoposide in NEC is poor and controversial, and different schedules and response rate have been published so far.""?",False, +16067960,Etoposide related to cutaneous neuroendocrine carcinoma,3573,"In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.","Is the triple ""Etoposide related to cutaneous neuroendocrine carcinoma"" supported by the sentence: ""In conclusion, orally administered etoposide in metastatic Merkel cell carcinoma was highly effective and well tolerated.""?",False, +15501025,Etoposide related to brain cancer,3574,"Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.","Is the triple ""Etoposide related to brain cancer"" supported by the sentence: ""Taken together, our results shed light on the mechanism of NF-kappaB activation by etoposide in brain tumours and show that the genetic background of MB and GM cells determines their sensitivity to chemotherapy and has to be taken into account for efficient therapeutic intervention.""?",False, +15141728,Etoposide related to testicular cancer,3575,[Continuous infusion of cisplatin plus etoposide in testicular cancer].,"Is the triple ""Etoposide related to testicular cancer"" supported by the sentence: ""[Continuous infusion of cisplatin plus etoposide in testicular cancer].""?",False, +15031494,Etoposide related to lymphoid leukemia,3576,"Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.","Is the triple ""Etoposide related to lymphoid leukemia"" supported by the sentence: ""Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.""?",False, +14511230,Etoposide related to glioblastoma,3577,Preliminary data by cis-platin and etoposide using in primary glioblastoma.,"Is the triple ""Etoposide related to glioblastoma"" supported by the sentence: ""Preliminary data by cis-platin and etoposide using in primary glioblastoma.""?",False, +14453465,Etoposide related to T-cell non-Hodgkin lymphoma,3578,High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).,"Is the triple ""Etoposide related to T-cell non-Hodgkin lymphoma"" supported by the sentence: ""High-dose CHOP plus etoposide (MegaCHOEP) in T-cell lymphoma: a comparative analysis of patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).""?",False, +13764189,"Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive",3579,Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.,"Is the triple ""Etoposide related to chronic myelogenous leukemia, BCR-ABL1 positive"" supported by the sentence: ""Early results from studies combining tipifarnib with imatinib or etoposide in CML and AML have been promising and warrant further evaluation in larger clinical trials.""?",False, +12298091,Etoposide related to breast neoplasm,3580,"Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.","Is the triple ""Etoposide related to breast neoplasm"" supported by the sentence: ""Herceptin, in combination with standard chemotherapy, such as taxol or etoposide, gives a synergistically apoptotic response in breast tumors.""?",False, +11028194,Etoposide related to acute lymphoblastic leukemia,3581,"Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.","Is the triple ""Etoposide related to acute lymphoblastic leukemia"" supported by the sentence: ""Etoposide (VP16-213), a topoisomerase II inhibitor, has produced complete responses in 17% of previously treated patients with acute nonlymphocytic leukemia (ANLL) but has little activity in acute lymphoblastic leukemia.""?",False, +10672040,Etoposide related to Ewing sarcoma,3582,Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.,"Is the triple ""Etoposide related to Ewing sarcoma"" supported by the sentence: ""Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone.""?",False, +10503115,Etoposide related to kidney cancer,3583,We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.,"Is the triple ""Etoposide related to kidney cancer"" supported by the sentence: ""We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.""?",False, +10441577,Etoposide related to chronic myelomonocytic leukemia,3584,"Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.","Is the triple ""Etoposide related to chronic myelomonocytic leukemia"" supported by the sentence: ""Other treatments for MDS include: IFN-alpha and etoposide, with responses primarily in chronic myelomonocytic leukemia; hem arginate, whose role is still not clear; and corticosteroids, but only in carefully selected cases.""?",False, +10410657,Etoposide related to neutropenia,3585,"The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).","Is the triple ""Etoposide related to neutropenia"" supported by the sentence: ""The day 29 etoposide or catechol area under the curve (AUC) was correlated with neutropenia (P =.027 and P =.0008, respectively).""?",False, +10182075,Etoposide related to non-Hodgkin lymphoma,3586,"Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.","Is the triple ""Etoposide related to non-Hodgkin lymphoma"" supported by the sentence: ""Ifosfamide, epirubicin and etoposide (IEV) in non-Hodgkin's lymphoma and Hodgkin's disease: the Italian experience.""?",False, +10161953,Etoposide related to squamous cell carcinoma,3587,"Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.","Is the triple ""Etoposide related to squamous cell carcinoma"" supported by the sentence: ""Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carcinoma of the cervix compared with bolus administration.""?",False, +9231982,Etoposide related to carcinoma,3588,"In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].","Is the triple ""Etoposide related to carcinoma"" supported by the sentence: ""In the 24 endometrial carcinomas examined, the mean Topo II a index and the I.R for doxorubicin and etoposide in the G1 carcinomas [22.2, 26.8, 21.5] were significantly lower than in the G2/G3 carcinomas [38.4, 54.0; p<0.001, 40.5; p<0.05].""?",False, +9157972,Etoposide related to thymoma,3589,"High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.","Is the triple ""Etoposide related to thymoma"" supported by the sentence: ""High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy.""?",False, +9138703,Etoposide related to ovarian cancer,3590,A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.,"Is the triple ""Etoposide related to ovarian cancer"" supported by the sentence: ""A phase II trial of intravenous etoposide (VP-16-213) in epithelial ovarian cancer resistant to cisplatin or carboplatin: clinical and serological evidence of activity.""?",False, +9115115,Etoposide related to sarcoma,3591,"The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.","Is the triple ""Etoposide related to sarcoma"" supported by the sentence: ""The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines.""?",False, +9024985,Etoposide related to leukemia,3592,The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.,"Is the triple ""Etoposide related to leukemia"" supported by the sentence: ""The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication.""?",False, +9008448,Etoposide related to Hodgkins lymphoma,3593,"Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.","Is the triple ""Etoposide related to Hodgkins lymphoma"" supported by the sentence: ""Because mechlorethamine, Oncovin, procarbazine, and prednisone (MOPP), and Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) are not suitable for major dose escalation, we evaluated the activity and toxicity of combined cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) in advanced HD, here used at conventional dose intensity, as a preparatory study prior to using this regimen at higher dose intensity.""?",False, +9006645,Etoposide related to neuroblastoma,3594,Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.,"Is the triple ""Etoposide related to neuroblastoma"" supported by the sentence: ""Etoposide induced apoptotic alterations similar to those caused by staurosporine in neuroblastoma but produced no detectable apoptotic changes in glioblastoma cells.""?",False, +8074798,Etoposide related to medulloblastoma,3595,"When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.","Is the triple ""Etoposide related to medulloblastoma"" supported by the sentence: ""When the child arrived in Italy with progressed metastatic medulloblastoma, she was treated with carboplatin/etoposide association i.v. followed by oral etoposide and partial surgery of the primitive mass.""?",False, +8048523,Etoposide related to lymphoma,3596,Oral etoposide in lymphoma.,"Is the triple ""Etoposide related to lymphoma"" supported by the sentence: ""Oral etoposide in lymphoma.""?",False, +7998504,Etoposide related to plasma cell myeloma,3597,"Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.","Is the triple ""Etoposide related to plasma cell myeloma"" supported by the sentence: ""Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol.""?",False, +7989979,Etoposide related to neoplasm,3598,"Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.","Is the triple ""Etoposide related to neoplasm"" supported by the sentence: ""Our aim was to determine the activity and toxicity of the cisplatin, etoposide, leucovorin, and 5-fluorouracil combination in initially unresectable tumors and to determine its ability to permit resection.""?",False, +7896801,Etoposide related to adult T-cell leukemia/lymphoma,3599,"Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.","Is the triple ""Etoposide related to adult T-cell leukemia/lymphoma"" supported by the sentence: ""Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.""?",False, +7845509,Etoposide related to glioma,3600,Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.,"Is the triple ""Etoposide related to glioma"" supported by the sentence: ""Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.""?",False, +7810052,Etoposide related to castration-resistant prostate carcinoma,3601,"Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.","Is the triple ""Etoposide related to castration-resistant prostate carcinoma"" supported by the sentence: ""Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer.""?",False, +7711547,Etoposide related to acute myeloid leukemia,3602,Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.,"Is the triple ""Etoposide related to acute myeloid leukemia"" supported by the sentence: ""Induction chemotherapy consisting of cytarabine (C) in combination with PSC 833 and escalating doses of mitoxantrone (M) and etoposide (E) over 5 or 6 days were tested in two phase I/II studies in poor prognosis AML.""?",False, +7319060,Etoposide related to small cell lung carcinoma,3603,Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.,"Is the triple ""Etoposide related to small cell lung carcinoma"" supported by the sentence: ""Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer.""?",False, +7200681,Etoposide related to non-small cell lung carcinoma,3604,Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.,"Is the triple ""Etoposide related to non-small cell lung carcinoma"" supported by the sentence: ""Increasing dose intensity of cisplatin-etoposide in advanced nonsmall cell lung carcinoma: a phase III randomized trial of the Spanish Lung Cancer Group.""?",False, +23328204,Etoposide causes small cell lung carcinoma,3605,This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.,"Is the triple ""Etoposide causes small cell lung carcinoma"" supported by the sentence: ""This study aims to explore whether iron metabolism is involved in etoposide- and cisplatin-induced stemness in small cell lung cancer (SCLC) cells.""?",False, +12215704,Etoposide causes neoplasm,3606,"In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.","Is the triple ""Etoposide causes neoplasm"" supported by the sentence: ""In our case, however, chemotherapy, consisting of etoposide and high-dose ifosfamide, caused the tumor to shrink significantly.""?",False, +8706370,Etoposide causes neutropenia,3607,"The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.","Is the triple ""Etoposide causes neutropenia"" supported by the sentence: ""The starting doses of paclitaxel (135 mg/m2/24 hours) and etoposide (50 mg/m2/day x 3) caused severe neutropenia even with the addition of granulocyte colony-stimulating factor, and the trial was amended to administer the paclitaxel during 3 hours.""?",False, +7869845,Etoposide causes leukemia,3608,"There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.","Is the triple ""Etoposide causes leukemia"" supported by the sentence: ""There might, additionally, be a synergistic effect of cisplatin and etoposide on the induction of therapy-related leukemia.""?",False, +7642766,Etoposide causes acute myeloid leukemia,3609,Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.,"Is the triple ""Etoposide causes acute myeloid leukemia"" supported by the sentence: ""Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.""?",False, +27374335,Etoposide affects retinoblastoma,3610,"METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.","Is the triple ""Etoposide affects retinoblastoma"" supported by the sentence: ""METHODS: A prospective study was performed to assess the effects of a 2-month chemoreduction regimen of vincristine, etoposide, and carboplatin on massive retinoblastoma with total retinal detachment.""?",False, +26960810,Etoposide affects small cell lung carcinoma,3611,"BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.","Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""BACKGROUND: Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease.""?",False, +25269562,Etoposide affects hemophagocytic syndrome,3612,"She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.","Is the triple ""Etoposide affects hemophagocytic syndrome"" supported by the sentence: ""She experienced exacerbation of HLH even after initiating systemic chemotherapy with etoposide, dexamethasone, and cyclosporine.""?",False, +23238600,Etoposide affects choriocarcinoma,3613,[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].,"Is the triple ""Etoposide affects choriocarcinoma"" supported by the sentence: ""[Basic and clinical study of anticancer effect of etoposide on choriocarcinoma].""?",False, +18166706,Etoposide affects neuroblastoma,3614,Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.,"Is the triple ""Etoposide affects neuroblastoma"" supported by the sentence: ""Our data indicate that as a Trk inhibitor AZD6918 increased the sensitivity of NB to etoposide.""?",False, +17967080,Etoposide affects leukemia,3615,"Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Etoposide, a topoisomerase-II inhibitor, however, has been associated with a significant increase in secondary leukemia.""?",False, +17160632,Etoposide affects carcinoma,3616,The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.,"Is the triple ""Etoposide affects carcinoma"" supported by the sentence: ""The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.""?",False, +16724406,Etoposide affects neoplasm,3617,The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.,"Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II.""?",False, +16425822,Etoposide affects leukemia,3618,"Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.","Is the triple ""Etoposide affects leukemia"" supported by the sentence: ""Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor.""?",False, +15965763,Etoposide affects testicular cancer,3619,"Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).","Is the triple ""Etoposide affects testicular cancer"" supported by the sentence: ""Testicular cancer is the most common form of cancer among men of reproductive age and has a high cure rate associated with chemotherapy treatment with bleomycin, etoposide, and cis-platinum (BEP).""?",False, +12798395,Etoposide affects hematopoietic and lymphoid system neoplasm,3620,Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.,"Is the triple ""Etoposide affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies.""?",False, +11699750,Etoposide affects small cell lung carcinoma,3621,CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.,"Is the triple ""Etoposide affects small cell lung carcinoma"" supported by the sentence: ""CONCLUSIONS: Inhibition of IGF-IR signaling synergistically enhances the sensitivity of SCLC to etoposide and carboplatin.""?",False, +11396769,Etoposide affects chronic myelomonocytic leukemia,3622,"He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.","Is the triple ""Etoposide affects chronic myelomonocytic leukemia"" supported by the sentence: ""He was treated with intravenous or oral etoposide with consequent resolution of the pleuritis, indicating the pleural involvement of CMML.""?",False, +9913818,Etoposide affects acute erythroid leukemia,3623,"Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.","Is the triple ""Etoposide affects acute erythroid leukemia"" supported by the sentence: ""Because increased topo II alpha expression is associated with enhanced efficacy of topo II-poisoning antitumor drugs such as etoposide, the hypothesis tested in this report was whether NaB pretreatment could sensitize HL-60 myeloid leukemia and K562 erythroleukemia cells to etoposide-triggered DNA damage and cell death.""?",False, +9397866,Etoposide affects fallopian tube neoplasm,3624,Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.,"Is the triple ""Etoposide affects fallopian tube neoplasm"" supported by the sentence: ""Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.""?",False, +9293530,Etoposide affects carcinoid tumor,3625,Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.,"Is the triple ""Etoposide affects carcinoid tumor"" supported by the sentence: ""Cisplatinum plus etoposide have demonstrated significant antitumour effects in anaplastic endocrine pancreatic tumours and lung carcinoids.""?",False, +8200378,Etoposide affects neoplasm,3626,"Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.","Is the triple ""Etoposide affects neoplasm"" supported by the sentence: ""Xenografts of small cell lung carcinoma (SCLC) from eight patients were used to test the tumor sensitivity to etoposide (VP16; 12-16 mg/kg/days, days 1, 2, and 3), cisplatin (CDDP; 6-9 mg/kg/day, day 1) and ifosfamide (IFO; 90-210 mg/kg/day, days 1, 2, and 3) as single agents and to evaluate the efficacy of the two-drug or three-drug combinations.""?",False, +8003315,Etoposide affects cutaneous neuroendocrine carcinoma,3627,"We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.","Is the triple ""Etoposide affects cutaneous neuroendocrine carcinoma"" supported by the sentence: ""We suggest that orally administered etoposide, a topoisomerase II inhibitor, has a strong antitumor effect in advanced Merkel cell carcinoma, even in patients previously treated parenterally with the same drug.""?",False, +7908520,Etoposide affects B-cell neoplasm,3628,CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).,"Is the triple ""Etoposide affects B-cell neoplasm"" supported by the sentence: ""CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L).""?",False, +24115005,Etoposide disrupts small cell lung carcinoma,3629,In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.,"Is the triple ""Etoposide disrupts small cell lung carcinoma"" supported by the sentence: ""In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide.""?",False, +17149618,Etoposide disrupts hemophagocytic syndrome,3630,Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).,"Is the triple ""Etoposide disrupts hemophagocytic syndrome"" supported by the sentence: ""Use of etoposide in the conditioning regimen was only factor that reduced HLH after SCT (P=0.027).""?",False, +16511954,Etoposide disrupts glioblastoma,3631,"In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.","Is the triple ""Etoposide disrupts glioblastoma"" supported by the sentence: ""In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model.""?",False, +16039903,Etoposide disrupts neoplasm,3632,"While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).","Is the triple ""Etoposide disrupts neoplasm"" supported by the sentence: ""While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls).""?",False, +14383828,Etoposide disrupts bone osteosarcoma,3633,CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).,"Is the triple ""Etoposide disrupts bone osteosarcoma"" supported by the sentence: ""CONCLUSIONS: Cyclophosphamide and etoposide x2 may arrest osteosarcoma progression in a significant number of patients (54%).""?",False, +9134229,Etoposide prevents neoplasm,3634,CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.,"Is the triple ""Etoposide prevents neoplasm"" supported by the sentence: ""CONCLUSION: Quantitative PCR enables one to monitor the kinetics of tumor reduction in patients treated with MINE chemotherapy in combination with Rituximab.""?",False, +22634859,Etoposide predisposes neoplasm,3635,Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.,"Is the triple ""Etoposide predisposes neoplasm"" supported by the sentence: ""Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells.BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance.""?",False, +18673787,Etoposide predisposes brain cancer,3636,"Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.","Is the triple ""Etoposide predisposes brain cancer"" supported by the sentence: ""Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors.""?",False, +16345738,Etoposide predisposes myelodysplastic syndrome,3637,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes myelodysplastic syndrome"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, +16345737,Etoposide predisposes acute myeloid leukemia,3638,"Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).","Is the triple ""Etoposide predisposes acute myeloid leukemia"" supported by the sentence: ""Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML).""?",False, +10333072,Etoposide predisposes leukemia,3639,"Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.","Is the triple ""Etoposide predisposes leukemia"" supported by the sentence: ""Etoposide, a DNA topoisomerase II inhibitor, is a significant risk factor for developing leukaemia; the risk appears to be correlated with the total dose given.""?",False, +16677028,Teniposide related to neoplasm,3640,"Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.","Is the triple ""Teniposide related to neoplasm"" supported by the sentence: ""Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy.""?",False, +10688707,Teniposide related to lymphoma,3641,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to lymphoma"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, +10688706,Teniposide related to leukemia,3642,The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.,"Is the triple ""Teniposide related to leukemia"" supported by the sentence: ""The limited clinical data currently available on teniposide seem to warrant further clinical trials with this agent in leukemias and lymphomas.""?",False, +27095076,Teniposide affects leukemia,3643,"These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.","Is the triple ""Teniposide affects leukemia"" supported by the sentence: ""These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors.""?",False, +26849066,Teniposide predisposes leukemia,3644,"CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.","Is the triple ""Teniposide predisposes leukemia"" supported by the sentence: ""CONCLUSION: In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia.""?",False, +18768362,Urofollitropin related to hypogonadism,3645,"RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.","Is the triple ""Urofollitropin related to hypogonadism"" supported by the sentence: ""RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypogonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.""?",False, +18095820,Urofollitropin related to primary ovarian failure,3646,"In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.","Is the triple ""Urofollitropin related to primary ovarian failure"" supported by the sentence: ""In addition, logistic binary regression analysis and linear regression analysis showed the miR-22-3p to be a protective factor for POF (odds ratio 0.766, 95% CI 0.643-0.912) and negatively associated with serum FSH.""?",False, +9960851,Urofollitropin related to anovulation,3647,Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.,"Is the triple ""Urofollitropin related to anovulation"" supported by the sentence: ""Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation.""?",False, +9716197,Urofollitropin related to female infertility,3648,OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.,"Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.""?",False, +8496709,Urofollitropin related to infertility disorder,3649,"BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.","Is the triple ""Urofollitropin related to infertility disorder"" supported by the sentence: ""BACKGROUND: Until recently, the main source of exogenous follicle stimulating hormone (FSH) for therapeutic use in infertility had been the urine of postmenopausal women.""?",False, +8454088,Urofollitropin related to male infertility,3650,Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.,"Is the triple ""Urofollitropin related to male infertility"" supported by the sentence: ""Pure follicle-stimulating hormone as an adjuvant therapy for selected cases in male infertility during in-vitro fertilization is beneficial.""?",False, +8378642,Urofollitropin related to polycystic ovary syndrome,3651,"From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.","Is the triple ""Urofollitropin related to polycystic ovary syndrome"" supported by the sentence: ""From the clinical point of view, clinicians nowadays tend to stimulate polycystic ovary syndrome patients with recombinant FSH plus the application of GnRH analogs in a long protocol.""?",False, +8205307,Urofollitropin related to azoospermia,3652,"Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.","Is the triple ""Urofollitropin related to azoospermia"" supported by the sentence: ""Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.""?",False, +14878529,Urofollitropin related to female infertility,3653,"OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).","Is the triple ""Urofollitropin related to female infertility"" supported by the sentence: ""OBJECTIVE: The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS).""?",False, +9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3654,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, +9422493,Urofollitropin related to Follicle Stimulating Hormone Receptor,3655,"Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.","Is the triple ""Urofollitropin related to Follicle Stimulating Hormone Receptor"" supported by the sentence: ""Folds of increase were markedly higher in case of rat FSH-R construct transfection, comparing to human FSH-R promoter.""?",False, +10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3656,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, +10444908,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3657,"However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, inclusion of FSH (30 ng/ml) in the culture medium prevented the decline in FSH receptor mRNA levels.""?",False, +7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3658,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, +7103614,Urofollitropin coexists with Follicle Stimulating Hormone Receptor,3659,"However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.","Is the triple ""Urofollitropin coexists with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""However, elucidation of the structure and function in human FSH receptor using the cDNA will be applicable to diagnosis of some clinical cases associated with abnormal FSH receptor gene in the future.""?",False, +7302412,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3660,The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.,"Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The regulation by FSH of FSH receptor expression and function were further studied using cultured granulosa cells of diethylstilbestrol (DES)-primed immature rats.""?",False, +7606444,Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor,3661,"The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.","Is the triple ""Urofollitropin physically interacts with Follicle Stimulating Hormone Receptor"" supported by the sentence: ""The finding that T augments follicular FSHR expression suggests that androgens promote follicular growth and estrogen biosynthesis indirectly, by amplifying FSH effect, and may partially explain the enhanced responsiveness to gonadotropin stimulation noted in women with polycystic ovary syndrome.""?",False, +21372974,Urofollitropin causes polycystic ovary syndrome,3662,"In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.","Is the triple ""Urofollitropin causes polycystic ovary syndrome"" supported by the sentence: ""In PCOS, the increased GnRH release led to a high level of LH pulsatility, impairing the preferential release of FSH and follicular maturation, thus leading to polycystic ovaries.""?",False, +16723493,Urofollitropin causes hypogonadism,3663,"FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.","Is the triple ""Urofollitropin causes hypogonadism"" supported by the sentence: ""FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism.""?",False, +16322495,Urofollitropin causes azoospermia,3664,Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.,"Is the triple ""Urofollitropin causes azoospermia"" supported by the sentence: ""Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu.""?",False, +9453052,Urofollitropin causes primary ovarian failure,3665,"An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.","Is the triple ""Urofollitropin causes primary ovarian failure"" supported by the sentence: ""An Ala189Val mutation of the human FSH receptor (FSHR) has been found to cause hypergonadotrophic ovarian failure with arrest of follicular maturation in women, and suppressed spermatogenesis in men.""?",False, +8923757,Urofollitropin causes Pregnancy,3666,"However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.","Is the triple ""Urofollitropin causes Pregnancy"" supported by the sentence: ""However, basal FSH screening alone or in combination with other screening methods would cause an unacceptably high loss rate of unaffected pregnancies compared with current screening protocols, indicating that routine pre-conception basal FSH screening would not be useful to identify women at risk for a Down's syndrome pregnancy.""?",False, +8815215,Urofollitropin causes anovulation,3667,"Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.","Is the triple ""Urofollitropin causes anovulation"" supported by the sentence: ""Because increased GnRH pulse frequency is at least a contributor to the secretion of excess LH and insufficient FSH that are the proximate cause of chronic anovulation in PCOS, strategies to slow the GnRH pulse generator are likely to promote ovulation in women with PCOS.""?",False, +8590972,Urofollitropin causes male infertility,3668,"Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.","Is the triple ""Urofollitropin causes male infertility"" supported by the sentence: ""Therefore, bilateral varicocele (grade 3) is associated with significant reduction in testicular function with significant increase in serum levels of FSH and LH, which may cause erectile dysfunction and male infertility.""?",False, +8270576,Urofollitropin causes infertility disorder,3669,Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.,"Is the triple ""Urofollitropin causes infertility disorder"" supported by the sentence: ""Inactivating FSH ligand and receptor mutations cause infertility because of a lack of follicular maturation in women.""?",False, +19357829,Urofollitropin affects gonadal disorder,3670,"Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.","Is the triple ""Urofollitropin affects gonadal disorder"" supported by the sentence: ""Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age.""?",False, +15865492,Urofollitropin affects polycystic ovary syndrome,3671,"The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.","Is the triple ""Urofollitropin affects polycystic ovary syndrome"" supported by the sentence: ""The AMH overproduction in anovulatory polycystic ovaries (PCO) may therefore restrict folliculogenesis by an inhibitory effect on FSH sensitivity, thereby contributing to anovulation.""?",False, +14984090,Urofollitropin affects male infertility,3672,The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.""?",False, +13249247,Urofollitropin affects Pregnancy,3673,"CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.","Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""CONCLUSION(S): This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.""?",False, +10980447,Urofollitropin affects Pregnancy,3674,BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.,"Is the triple ""Urofollitropin affects Pregnancy"" supported by the sentence: ""BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies.""?",False, +8590971,Urofollitropin affects male infertility,3675,The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.,"Is the triple ""Urofollitropin affects male infertility"" supported by the sentence: ""The mean serum FSH was significantly increased in male infertility (p < .05) and nonsignificant in impotent patients compared to controls.""?",False, +7302415,Urofollitropin affects Follicle Stimulating Hormone Receptor,3676,These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""These data showed that the FSH is essential for the suppression of the FSH receptor function in the adenylyl cyclase pathway.""?",False, +9844029,Urofollitropin affects Follicle Stimulating Hormone Receptor,3677,This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.,"Is the triple ""Urofollitropin affects Follicle Stimulating Hormone Receptor"" supported by the sentence: ""This suggests that the FSH receptor genotype can influence the ovarian response to FSH stimulation.""?",False, +27587327,Urofollitropin produces primary ovarian failure,3678,"Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).","Is the triple ""Urofollitropin produces primary ovarian failure"" supported by the sentence: ""Although the women with premature ovarian failure secreted more follicle-stimulating hormone in the absence and presence of estradiol, only the former situation was statistically significant (p=0.0008 and p=0.23, respectively).""?",False, +20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3679,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, +20465917,Urofollitropin produces Follicle Stimulating Hormone Receptor,3680,"In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.","Is the triple ""Urofollitropin produces Follicle Stimulating Hormone Receptor"" supported by the sentence: ""In order to obtain the eelFSHR ligand, we produced recombinant follicle-stimulating hormone (rec-eelFSHbeta/alpha) in the CHO-suspension cells.""?",False, +8502213,Urofollitropin produces polycystic ovary syndrome,3681,"RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.","Is the triple ""Urofollitropin produces polycystic ovary syndrome"" supported by the sentence: ""RESULTS: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls.""?",False, +20569186,Urofollitropin disrupts Pregnancy,3682,"RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.","Is the triple ""Urofollitropin disrupts Pregnancy"" supported by the sentence: ""RESULTS: All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate.""?",False, +11195885,Urofollitropin prevents azoospermia,3683,"While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.","Is the triple ""Urofollitropin prevents azoospermia"" supported by the sentence: ""While active as well as passive immunization against FSH reduced spermatogenesis severely, azoospermia could not be achieved consistently.""?",False, +17502146,Urofollitropin predisposes azoospermia,3684,"On multivariate analysis, only FSH remained predictive of NOA.","Is the triple ""Urofollitropin predisposes azoospermia"" supported by the sentence: ""On multivariate analysis, only FSH remained predictive of NOA.""?",False, +16417247,Urofollitropin predisposes anovulation,3685,"CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.","Is the triple ""Urofollitropin predisposes anovulation"" supported by the sentence: ""CONCLUSIONS: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation.""?",False, +16278695,Urofollitropin predisposes infertility disorder,3686,"The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).","Is the triple ""Urofollitropin predisposes infertility disorder"" supported by the sentence: ""The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers).""?",False, +15110465,Urofollitropin predisposes polycystic ovary syndrome,3687,"LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).","Is the triple ""Urofollitropin predisposes polycystic ovary syndrome"" supported by the sentence: ""LH/FSH (OR = 1.51; 95% CI: 1.16-1.96; P = 0.01) and InHOMA-IR (OR = 1.26; 95% CI: 1.10-1.44; P = 0.01) were risk factors of PCOS, and waist hip ratio was that of PCOS-insulin resistance (OR = 8.57; 95% CI, 2.14-34.30, P = 0.01).""?",False, +7379891,Urofollitropin predisposes primary ovarian failure,3688,Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.,"Is the triple ""Urofollitropin predisposes primary ovarian failure"" supported by the sentence: ""Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women.""?",False, +23895216,Ivacaftor affects cystic fibrosis,3689,Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.,"Is the triple ""Ivacaftor affects cystic fibrosis"" supported by the sentence: ""Using negative control outcomes and difference-in-differences to estimate treatment effects in an entirely treated cohort: the effect of ivacaftor in cystic fibrosis.""?",False, +20354463,Nitric oxide related to ST-elevation myocardial infarction,3690,The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.,"Is the triple ""Nitric oxide related to ST-elevation myocardial infarction"" supported by the sentence: ""The observed functional recovery and clinical event rates at follow-up and possible interaction with nitroglycerine warrant further studies of iNO in STEMI.""?",False, +17273075,Nitric oxide related to bronchiolitis,3691,"By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.","Is the triple ""Nitric oxide related to bronchiolitis"" supported by the sentence: ""By multivariate regression analyses, atopy, height (p < 0.001 for both) and BHR (p = 0.034), but not asthma (p = 0.805) or hospitalization for bronchiolitis (p = 0.359), were associated with FeNO in the post-bronchiolitis and control groups.""?",False, +15880296,Nitric oxide related to Diabetic Foot,3692,"Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).","Is the triple ""Nitric oxide related to Diabetic Foot"" supported by the sentence: ""Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 +/- 0.4 and 8 +/- 0.4 vs 42 +/- 2.5 MUmol/L, respectively; P < 0.05).""?",False, +14910010,Nitric oxide related to severe acute respiratory syndrome,3693,Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.,"Is the triple ""Nitric oxide related to severe acute respiratory syndrome"" supported by the sentence: ""Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS.""?",False, +14573099,Nitric oxide related to bronchopulmonary dysplasia,3694,"The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.","Is the triple ""Nitric oxide related to bronchopulmonary dysplasia"" supported by the sentence: ""The proposed role of novel molecular therapies, and the combined effects of currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term pulmonary morbidity among infants delivered prematurely.""?",False, +11752178,Nitric oxide related to cutaneous leishmaniasis,3695,"Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.","Is the triple ""Nitric oxide related to cutaneous leishmaniasis"" supported by the sentence: ""Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis.""?",False, +9816415,Nitric oxide related to newborn respiratory distress syndrome,3696,"To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.","Is the triple ""Nitric oxide related to newborn respiratory distress syndrome"" supported by the sentence: ""To elucidate the role of NO in RDS and low blood pressure, we determined the endogenous NO production in infants with and without RDS by measuring urinary nitrite and nitrate excretions and plasma cGMP levels.""?",False, +9774015,Nitric oxide related to respiratory system disorder,3697,Nitric oxide in respiratory diseases.,"Is the triple ""Nitric oxide related to respiratory system disorder"" supported by the sentence: ""Nitric oxide in respiratory diseases.""?",False, +8707490,Nitric oxide related to myocardial infarction,3698,"Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.","Is the triple ""Nitric oxide related to myocardial infarction"" supported by the sentence: ""Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.""?",False, +8593326,Nitric oxide related to neuralgia,3699,This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.,"Is the triple ""Nitric oxide related to neuralgia"" supported by the sentence: ""This study provides the first functional evidence that spinal nitric oxide interacts with the thiol-containing compounds to produce an antiallodynic effect in neuropathic pain.""?",False, +8476870,Nitric oxide related to lung disorder,3700,"Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.","Is the triple ""Nitric oxide related to lung disorder"" supported by the sentence: ""Among the researches developed, the use of inhalation of NO gas allowed us to propose this therapy in lung diseases with promising results.""?",False, +8350800,Nitric oxide related to opiate dependence,3701,"RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.","Is the triple ""Nitric oxide related to opiate dependence"" supported by the sentence: ""RATIONALE: There is increasing evidence that the N-methyl-D-aspartate (NMDA) receptor and the nitric oxide system are involved in opiate dependence in the adult rat, but whether these results in the adult apply to the infant rat is unknown.""?",False, +8343542,Nitric oxide related to Varicose Ulcer,3702,"NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.","Is the triple ""Nitric oxide related to Varicose Ulcer"" supported by the sentence: ""NO overexpression in chronic venous ulcers may be involved directly or indirectly (through production of peroxynitrite) in the pathogenesis and delayed healing of chronic venous ulcers, through its effects on vasculature, inflammation, and collagen deposition.""?",False, +8057943,Nitric oxide related to malaria,3703,Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.,"Is the triple ""Nitric oxide related to malaria"" supported by the sentence: ""Nitric oxide in murine malaria: divergent roles in blood and brain suggested by voltametric measures.""?",False, +8040944,Nitric oxide related to sickle cell anemia,3704,Strategies that enhance NO activity may be therapeutic in sickle cell disease.,"Is the triple ""Nitric oxide related to sickle cell anemia"" supported by the sentence: ""Strategies that enhance NO activity may be therapeutic in sickle cell disease.""?",False, +7963930,Nitric oxide related to cystic fibrosis,3705,"As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.","Is the triple ""Nitric oxide related to cystic fibrosis"" supported by the sentence: ""As NO has been shown to oppose neutrophil sequestration, its relative lack in CF may underlie the heavy neutrophilic infiltration that characterizes the disease.""?",False, +7923041,Nitric oxide related to brain injury,3706,"While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.","Is the triple ""Nitric oxide related to brain injury"" supported by the sentence: ""While NO normally functions as a physiological neuronal mediator, excess production of NO mediates brain injury.""?",False, +7788094,Nitric oxide related to myocardial ischemia,3707,"This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.","Is the triple ""Nitric oxide related to myocardial ischemia"" supported by the sentence: ""This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic myocardium.""?",False, +7738003,Nitric oxide related to Hypoxemia,3708,"In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.","Is the triple ""Nitric oxide related to Hypoxemia"" supported by the sentence: ""In this study, we examined the expression and localization of soluble guanylate cyclase (sGC), the primary receptor for NO, in hypoxia- and normoxia-treated rat lungs.""?",False, +7725812,Nitric oxide related to Premature birth,3709,"Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.","Is the triple ""Nitric oxide related to Premature birth"" supported by the sentence: ""Low-dose nitric oxide in the most critically ill premature neonates does not increase the risk of intracranial haemorrhage, and may decrease risk of chronic lung injury.""?",False, +7657450,Nitric oxide related to pulmonary embolism,3710,Use of inhaled nitric oxide in pulmonary embolism.,"Is the triple ""Nitric oxide related to pulmonary embolism"" supported by the sentence: ""Use of inhaled nitric oxide in pulmonary embolism.""?",False, +7539810,Nitric oxide related to stroke disorder,3711,The findings indicate the importance of nitric oxide in stroke and ischemia.,"Is the triple ""Nitric oxide related to stroke disorder"" supported by the sentence: ""The findings indicate the importance of nitric oxide in stroke and ischemia.""?",False, +7481315,Nitric oxide related to chronic obstructive pulmonary disease,3712,Exhaled nitric oxide in COPD: glancing through a smoke screen.,"Is the triple ""Nitric oxide related to chronic obstructive pulmonary disease"" supported by the sentence: ""Exhaled nitric oxide in COPD: glancing through a smoke screen.""?",False, +7449413,Nitric oxide related to respiratory failure,3713,Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.,"Is the triple ""Nitric oxide related to respiratory failure"" supported by the sentence: ""Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure.""?",False, +7439172,Nitric oxide related to neoplasm,3714,"Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.","Is the triple ""Nitric oxide related to neoplasm"" supported by the sentence: ""Considering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production.""?",False, +7418030,Nitric oxide related to acute kidney failure,3715,BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.,"Is the triple ""Nitric oxide related to acute kidney failure"" supported by the sentence: ""BACKGROUND: The role of nitric oxide (NO) in acute renal failure (ARF) is not yet completely understood.""?",False, +7373096,Nitric oxide related to brain ischemia,3716,"Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.","Is the triple ""Nitric oxide related to brain ischemia"" supported by the sentence: ""Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective inhibition of nitric oxide synthase (NOS) isoforms or transgenic animals, is progressively clarifying the precise role of nitric oxide in brain ischemia.""?",False, +7345317,Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins,3717,"CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.","Is the triple ""Nitric oxide related to alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""CONCLUSION: Dypiridamole enhanced the response to iNO in PPHN associated with CDH, although this effect was transient.""?",False, +7242606,Nitric oxide related to adult acute respiratory distress syndrome,3718,Inhaled nitric oxide may also have therapeutic potential in ARDS.,"Is the triple ""Nitric oxide related to adult acute respiratory distress syndrome"" supported by the sentence: ""Inhaled nitric oxide may also have therapeutic potential in ARDS.""?",False, +7159413,Nitric oxide related to Sepsis,3719,"CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.","Is the triple ""Nitric oxide related to Sepsis"" supported by the sentence: ""CONCLUSIONS: The time course and pattern of changes in expired NO during endotoxemia followed the change in systemic hemodynamics, which supports a causal role for NO in sepsis.""?",False, +7145311,Nitric oxide related to Inflammation,3720,Nitric oxide protects in intestinal inflammation.,"Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Nitric oxide protects in intestinal inflammation.""?",False, +7091337,Nitric oxide related to ischemia reperfusion injury,3721,This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.,"Is the triple ""Nitric oxide related to ischemia reperfusion injury"" supported by the sentence: ""This suggests that nitric oxide and free radicals are involved and interact in synergy in ischemia-reperfusion injury.""?",False, +14184908,Nitric oxide related to Inflammation,3722,"Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.","Is the triple ""Nitric oxide related to Inflammation"" supported by the sentence: ""Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis.""?",False, +27698007,Nitric oxide causes lung disorder,3723,"Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.","Is the triple ""Nitric oxide causes lung disorder"" supported by the sentence: ""Recent studies have implicated nitric oxide and peroxynitrite in the pathogenesis of many diseases, such as septic shock, arthritis, lung disease, and atherosclerosis.""?",False, +23636922,Nitric oxide causes Infection,3724,"Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.","Is the triple ""Nitric oxide causes Infection"" supported by the sentence: ""Consequently, invading bacteria can proliferate inside the body of mammals by bypassing the immune defense mechanism involving NO and may thus lead to harmful infections.""?",False, +22013082,Nitric oxide causes sickle cell anemia,3725,"Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.","Is the triple ""Nitric oxide causes sickle cell anemia"" supported by the sentence: ""Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability.""?",False, +21447838,Nitric oxide causes respiratory system disorder,3726,NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.,"Is the triple ""Nitric oxide causes respiratory system disorder"" supported by the sentence: ""NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases.""?",False, +14028136,Nitric oxide causes stroke disorder,3727,"OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.","Is the triple ""Nitric oxide causes stroke disorder"" supported by the sentence: ""OBJECTIVE: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity.""?",False, +12046903,Nitric oxide causes cystic fibrosis,3728,CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.,"Is the triple ""Nitric oxide causes cystic fibrosis"" supported by the sentence: ""CONCLUSIONS: These data suggest that increased sputum arginase activity contributes to nitric oxide deficiency in CF lung disease and may be relevant in the pathogenesis of CF airway disease.""?",False, +11887505,Nitric oxide causes myocardial ischemia,3729,"RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.","Is the triple ""Nitric oxide causes myocardial ischemia"" supported by the sentence: ""RESULTS: Coronary stenosis impaired myocardial endothelial NO function and reduced coronary flow reserve, evoking myocardial ischemia, as shown by PKC- activation, myocardial inflammation, fibrosis, cardiac dysfunction, and remodeling.""?",False, +11842330,Nitric oxide causes ischemia reperfusion injury,3730,BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).,"Is the triple ""Nitric oxide causes ischemia reperfusion injury"" supported by the sentence: ""BACKGROUND: Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in allografts by expression of inducible (i) NO synthase (NOS).""?",False, +11556568,Nitric oxide causes acute kidney failure,3731,NO plays a dual role of protection and damage in the pathogenesis of ARF.,"Is the triple ""Nitric oxide causes acute kidney failure"" supported by the sentence: ""NO plays a dual role of protection and damage in the pathogenesis of ARF.""?",False, +11353052,Nitric oxide causes adult acute respiratory distress syndrome,3732,"CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.","Is the triple ""Nitric oxide causes adult acute respiratory distress syndrome"" supported by the sentence: ""CONCLUSION: ARDS rats showed a lastecl increase of CO level in pulmonary blood circulation, suggesting CO/HO system might play a more important role in modulation of blood vessel tension than NO might do in pathogenesis of ARDS.""?",False, +9962165,Nitric oxide causes malaria,3733,We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.,"Is the triple ""Nitric oxide causes malaria"" supported by the sentence: ""We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria.""?",False, +9795722,Nitric oxide causes neuralgia,3734,OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.,"Is the triple ""Nitric oxide causes neuralgia"" supported by the sentence: ""OBJECTIVE: Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain.""?",False, +9068211,Nitric oxide causes pneumonia,3735,"A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.","Is the triple ""Nitric oxide causes pneumonia"" supported by the sentence: ""A histochemical study demonstrated that NO damaged bronchial epithelial cells, and thereby apparently inducing pneumonitis.""?",False, +8934561,Nitric oxide causes brain injury,3736,"It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.","Is the triple ""Nitric oxide causes brain injury"" supported by the sentence: ""It is well established that there are many conditions, including those mediated by nitric oxide (NO), that can lead to an opening of the BBB, eventually leading to vasogenic edema and secondary brain damage.""?",False, +8855613,Nitric oxide causes neoplasm,3737,Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.,"Is the triple ""Nitric oxide causes neoplasm"" supported by the sentence: ""Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.""?",False, +8834736,Nitric oxide causes myocardial infarction,3738,"Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.","Is the triple ""Nitric oxide causes myocardial infarction"" supported by the sentence: ""Therefore, we have investigated the implication of NO in HS-induced resistance to myocardial infarction, in the isolated rat heart model.""?",False, +8346309,Nitric oxide causes Premature birth,3739,The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.,"Is the triple ""Nitric oxide causes Premature birth"" supported by the sentence: ""The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model.""?",False, +8185371,Nitric oxide causes Inflammation,3740,Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.,"Is the triple ""Nitric oxide causes Inflammation"" supported by the sentence: ""Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.""?",False, +8037779,Nitric oxide causes brain ischemia,3741,"Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.","Is the triple ""Nitric oxide causes brain ischemia"" supported by the sentence: ""Since not all patients can receive thiopentone sodium before cerebral ischaemia occurs, we investigated the influence of timing of thiopentone sodium administration on the neurotoxicity induced by nitric oxide (NO) using Shibuta's established model of primary brain cultures.""?",False, +7409857,Nitric oxide causes Sepsis,3742,Nitric oxide in the pathogenesis of sepsis.,"Is the triple ""Nitric oxide causes Sepsis"" supported by the sentence: ""Nitric oxide in the pathogenesis of sepsis.""?",False, +7184490,Nitric oxide causes Hypoxemia,3743,These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.,"Is the triple ""Nitric oxide causes Hypoxemia"" supported by the sentence: ""These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury.""?",False, +27626134,Nitric oxide affects cystic fibrosis,3744,"We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.","Is the triple ""Nitric oxide affects cystic fibrosis"" supported by the sentence: ""We therefore measured exhaled NO and sputum NO2/NO3 in three subject categories: patients with acute pulmonary exacerbation of CF, patients with stable CF, and healthy control subjects.""?",False, +27208311,Nitric oxide affects opiate dependence,3745,"NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.","Is the triple ""Nitric oxide affects opiate dependence"" supported by the sentence: ""NO may, therefore, play a role in both phases of morphine tolerance and dependence: elevation of NO levels during the induction phase delays the development of opioid tolerance/dependence, while inhibition of NO synthase accelerates the development of tolerance.""?",False, +27058878,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3746,The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.,"Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""The variability of the response time to inhaled NO is likely to be multifactorial and dependent on the disease process associated with PPHN.""?",False, +20413999,Nitric oxide affects brain injury,3747,"Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.","Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Increased levels of NO can be maintained by the activity of inducible NO synthase (NOS2A) on its own or activated by IL-1beta (IL-1beta) gene transcription and positive back stimulation of the NOS2 (CCTTT)n microsatellite by IL-1beta, thus potentiating brain injury after ischemic perinatal asphyxia.""?",False, +19764415,Nitric oxide affects pneumonia,3748,"Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""Because 5-LO contains critical nucleophilic amino acids, which are sensitive to electrophilic modifications, we determined the consequences of a drug-mediated intracellular release of nitric oxide (NO) on 5-LO product formation by human granulocytes and on 5-LO-dependent pulmonary inflammation in vivo.""?",False, +18632674,Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins,3749,"We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.","Is the triple ""Nitric oxide affects alveolar capillary dysplasia with misalignment of pulmonary veins"" supported by the sentence: ""We conclude that ventilation with 100% O2 amplifies oxidative stress and mitochondrial dysfunction in PPHN, which are partly improved by iNO and weaning of oxygen.""?",False, +17798838,Nitric oxide affects neuralgia,3750,"All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.","Is the triple ""Nitric oxide affects neuralgia"" supported by the sentence: ""All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain.""?",False, +17030125,Nitric oxide affects bronchiolitis,3751,Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.,"Is the triple ""Nitric oxide affects bronchiolitis"" supported by the sentence: ""Successful use of inhaled nitric oxide for severe hypoxemia in an infant with acute exacerbation of bronchiolitis due to sepsis.""?",False, +12566083,Nitric oxide affects respiratory system disorder,3752,Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.,"Is the triple ""Nitric oxide affects respiratory system disorder"" supported by the sentence: ""Fractional exhaled (FE(NO)) and nasal NO (FN(NO)) are known to be altered in several respiratory tract disease and disorders.""?",False, +11778681,Nitric oxide affects stroke disorder,3753,Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.,"Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility.""?",False, +11521495,Nitric oxide affects severe acute respiratory syndrome,3754,"These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.","Is the triple ""Nitric oxide affects severe acute respiratory syndrome"" supported by the sentence: ""These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.""?",False, +11353389,Nitric oxide affects myocardial infarction,3755,Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.,"Is the triple ""Nitric oxide affects myocardial infarction"" supported by the sentence: ""Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.""?",False, +10403969,Nitric oxide affects anemia,3756,"Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Decrease of NO level as early as possible will benefit to block the development of anemia, that will provide a new strategy of therapy for ACD.""?",False, +10222313,Nitric oxide affects ischemia reperfusion injury,3757,CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.,"Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""CONCLUSION: Pue exerts inhibitive effect only after NO production is enhanced sharply during hypoxia/reperfusion injury in a dose-dependent trend.""?",False, +10099288,Nitric oxide affects myocardial ischemia,3758,Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion.""?",False, +10018002,Nitric oxide affects acute kidney failure,3759,"Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.","Is the triple ""Nitric oxide affects acute kidney failure"" supported by the sentence: ""Historically, NO has been implicated in ARF and, after its discovery, several publications have suggested that changes in NO production could play an important role in the hemodynamic alterations observed in ARF.""?",False, +10008267,Nitric oxide affects lung disorder,3760,"Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.","Is the triple ""Nitric oxide affects lung disorder"" supported by the sentence: ""Nitric oxide (NO), a simple free-radical gas, elicits a diverse range of physiologic and pathophysiologic effects, and plays an important role in pulmonary diseases.""?",False, +9982988,Nitric oxide affects respiratory failure,3761,Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.,"Is the triple ""Nitric oxide affects respiratory failure"" supported by the sentence: ""Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes.""?",False, +9910920,Nitric oxide affects brain ischemia,3762,These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.,"Is the triple ""Nitric oxide affects brain ischemia"" supported by the sentence: ""These protective activities of L-NAME suggest that NO has multiple deleterious effects in cerebral ischemia.""?",False, +9742582,Nitric oxide affects stroke disorder,3763,"The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.","Is the triple ""Nitric oxide affects stroke disorder"" supported by the sentence: ""The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset.""?",False, +9649727,Nitric oxide affects neoplasm,3764,Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""Nitric oxide (NO) is reported to have several important effects in the control of neoplasm.""?",False, +9102608,Nitric oxide affects Hypoxemia,3765,Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.,"Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum.""?",False, +9095187,Nitric oxide affects newborn respiratory distress syndrome,3766,"There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.","Is the triple ""Nitric oxide affects newborn respiratory distress syndrome"" supported by the sentence: ""There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS.""?",False, +8891949,Nitric oxide affects Sepsis,3767,"Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Because nitric oxide (NO) is implicated in the modulation of red blood cell (RBC) deformability and NO levels increase during sepsis, we tested the hypothesis that a NO-mediated decrease in RBC deformability contributes to decreased functional capillary density (CD) in remote organs.""?",False, +8832872,Nitric oxide affects pneumonia,3768,"The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.","Is the triple ""Nitric oxide affects pneumonia"" supported by the sentence: ""The aim of this study was to measure exhaled nitric oxide levels in patients admitted to hospital with acute exacerbations of asthma, or chronic obstructive pulmonary disease, or with pneumonia.""?",False, +8646255,Nitric oxide affects myocardial ischemia,3769,The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.,"Is the triple ""Nitric oxide affects myocardial ischemia"" supported by the sentence: ""The delayed cardioprotection was associated with a moderate but significant increase of nitric oxide level in the ischemic myocardium.""?",False, +8473168,Nitric oxide affects neoplasm,3770,NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.,"Is the triple ""Nitric oxide affects neoplasm"" supported by the sentence: ""NO would appear to have both tumour promoting and inhibiting effects which are presumed to be dependent on its local concentration within the tumour.""?",False, +8202584,Nitric oxide affects Sepsis,3771,"Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.","Is the triple ""Nitric oxide affects Sepsis"" supported by the sentence: ""Since there is increasing evidence indicating nitric oxide [NO] would play a role in sepsis, we decided to investigate whether this multifaceted mediator is directly implicated in the process of bacterial translocation.""?",False, +8139693,Nitric oxide affects brain injury,3772,Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.,"Is the triple ""Nitric oxide affects brain injury"" supported by the sentence: ""Treatment trials pertaining to modulate NO production in stroke should take into consideration the dual effect of NO on ischemic brain damage.""?",False, +7935763,Nitric oxide affects chronic obstructive pulmonary disease,3773,The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""The present study was undertaken to investigate the safety and efficacy of a mixture of nitric oxide (NO) and oxygen administered via a nasal cannula for 24 hours in patients with oxygen dependent COPD.""?",False, +7896362,Nitric oxide affects Inflammation,3774,"Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.","Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Airway NO levels are increased in airway inflammations, such as asthma and allergic rhinitis, but is reduced in cystic fibrosis and other conditions with ciliary dysfunction, sinusitis and after exposure to tobacco and alcohol.""?",False, +7780898,Nitric oxide affects chronic obstructive pulmonary disease,3775,Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.,"Is the triple ""Nitric oxide affects chronic obstructive pulmonary disease"" supported by the sentence: ""Serial measurements of exhaled nitric oxide during exacerbations of chronic obstructive pulmonary disease.""?",False, +7712088,Nitric oxide affects Hypoxemia,3776,"By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.","Is the triple ""Nitric oxide affects Hypoxemia"" supported by the sentence: ""By contrast, in the outer medulla, NO signals paradoxically rose following NOS inhibition, known to intensify local hypoxia.""?",False, +7542916,Nitric oxide affects anemia,3777,"Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).","Is the triple ""Nitric oxide affects anemia"" supported by the sentence: ""Expired NO increased with anemia, whereas it remained stable in control animals (P < 0.0001 between groups).""?",False, +7169788,Nitric oxide affects Inflammation,3778,Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.,"Is the triple ""Nitric oxide affects Inflammation"" supported by the sentence: ""Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis.""?",False, +7164340,Nitric oxide affects ischemia reperfusion injury,3779,"The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.","Is the triple ""Nitric oxide affects ischemia reperfusion injury"" supported by the sentence: ""The involvement of nitric oxide in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious, depending on the tissue and model used.""?",False, +7094195,Nitric oxide affects malaria,3780,Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.,"Is the triple ""Nitric oxide affects malaria"" supported by the sentence: ""Nitric oxide (NO) production has been suggested to play a role as effector molecule in the control of the malarial infections.""?",False, +20359925,Nitric oxide produces chronic obstructive pulmonary disease,3781,"However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.","Is the triple ""Nitric oxide produces chronic obstructive pulmonary disease"" supported by the sentence: ""However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD.""?",False, +20299429,Nitric oxide produces pneumonia,3782,We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.,"Is the triple ""Nitric oxide produces pneumonia"" supported by the sentence: ""We studied whether zanamivir reduces pulmonary inflammation through inhibition of NO production in mice.""?",False, +17925357,Nitric oxide produces bronchopulmonary dysplasia,3783,"The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.","Is the triple ""Nitric oxide produces bronchopulmonary dysplasia"" supported by the sentence: ""The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.""?",False, +15219259,Nitric oxide produces Premature birth,3784,CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.,"Is the triple ""Nitric oxide produces Premature birth"" supported by the sentence: ""CONCLUSIONS AND IMPLICATIONS: An infection-associated model of preterm labour showed that preterm delivery can be prevented by decreasing PG or NO production.""?",False, +13106727,Nitric oxide produces adult acute respiratory distress syndrome,3785,"Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.","Is the triple ""Nitric oxide produces adult acute respiratory distress syndrome"" supported by the sentence: ""Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both.""?",False, +12774415,Nitric oxide produces stroke disorder,3786,The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.,"Is the triple ""Nitric oxide produces stroke disorder"" supported by the sentence: ""The time course of nuclear translocation of AIF after experimental stroke may vary with the severity of injury and may be accelerated by oxidant stress associated with reperfusion and nitric oxide (NO) production.""?",False, +12205025,Nitric oxide produces Varicose Ulcer,3787,"The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.","Is the triple ""Nitric oxide produces Varicose Ulcer"" supported by the sentence: ""The aim of the study was to review the pathophysiological events culminating in venous ulceration, focusing primarily on the role of alterations in nitric oxide (NO) production.""?",False, +11786457,Nitric oxide produces brain ischemia,3788,"One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.","Is the triple ""Nitric oxide produces brain ischemia"" supported by the sentence: ""One of the responses to cerebral ischemia is an increase in the production of nitric oxide, catalyzed by enzymes expressed in both resident and infiltrating cells.""?",False, +9816411,Nitric oxide produces newborn respiratory distress syndrome,3789,Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.,"Is the triple ""Nitric oxide produces newborn respiratory distress syndrome"" supported by the sentence: ""Nitric oxide production and plasma cyclic guanosine monophosphate in premature infants with respiratory distress syndrome.""?",False, +8745644,Nitric oxide produces sickle cell anemia,3790,We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.,"Is the triple ""Nitric oxide produces sickle cell anemia"" supported by the sentence: ""We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls.""?",False, +8339020,Nitric oxide produces acute kidney failure,3791,"In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.","Is the triple ""Nitric oxide produces acute kidney failure"" supported by the sentence: ""In conclusion, in this model of acute renal failure the decrease in glomerular nitric oxide production plays an important role in the decrease in renal function.""?",False, +7963932,Nitric oxide produces cystic fibrosis,3792,The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.,"Is the triple ""Nitric oxide produces cystic fibrosis"" supported by the sentence: ""The reduced production of NO by CF compared with normal epithelium was shown by the presence of significantly (p<0.001) less accumulated nitrites in medium after co-culture with neutrophils.""?",False, +7644756,Nitric oxide produces anemia,3793,"Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.","Is the triple ""Nitric oxide produces anemia"" supported by the sentence: ""Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.""?",False, +7555266,Nitric oxide produces myocardial ischemia,3794,Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.,"Is the triple ""Nitric oxide produces myocardial ischemia"" supported by the sentence: ""Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.""?",False, +7511323,Nitric oxide produces myocardial infarction,3795,"The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).","Is the triple ""Nitric oxide produces myocardial infarction"" supported by the sentence: ""The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH).""?",False, +7507297,Nitric oxide produces Inflammation,3796,Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.,"Is the triple ""Nitric oxide produces Inflammation"" supported by the sentence: ""Our findings suggest that an inflammatory reaction of the basal forebrain facilitates GABA release through the production of nitric oxide.""?",False, +7461061,Nitric oxide produces Hypoxemia,3797,"Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.","Is the triple ""Nitric oxide produces Hypoxemia"" supported by the sentence: ""Our study suggests that hypoxia almost completely inhibits NO production, and that K(ATP) channel opening immediately after hypoxia and subsequent enhanced adenosine production cause a marked hypoxic coronary vasodilatation.""?",False, +7435212,Nitric oxide produces neoplasm,3798,"Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.","Is the triple ""Nitric oxide produces neoplasm"" supported by the sentence: ""Taken together, these data indicate that the reduced antitumor activities in murine peritoneal macrophages are mediated by the suppressed production of NO, TNF-alpha and H2O2 by AFB1 pretreatment, suggesting that the inhibitory effect of AFB1 on those materials may provide the tumors with readily growing condition in vivo.""?",False, +7390889,Nitric oxide produces Sepsis,3799,"In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.","Is the triple ""Nitric oxide produces Sepsis"" supported by the sentence: ""In sepsis, lipopolysaccharide (LPS) depresses cardiac function by inducing production of nitric oxide (NO) and its second messenger cGMP.""?",False, +7094197,Nitric oxide produces malaria,3800,"However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.","Is the triple ""Nitric oxide produces malaria"" supported by the sentence: ""However, C57BL/6 mice treated with AG lost their resistance to Pcc infections, suggesting that the requirement for NO production for parasite killing in murine blood-stage malaria might be strain dependent.""?",False, +26705109,Nitric oxide disrupts anemia,3801,"NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.","Is the triple ""Nitric oxide disrupts anemia"" supported by the sentence: ""NO production correlated directly with the development of anemia, and treatment of infected mice with NG-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia.""?",False, +19923810,Nitric oxide disrupts stroke disorder,3802,"CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.","Is the triple ""Nitric oxide disrupts stroke disorder"" supported by the sentence: ""CONCLUSIONS: A genetic predisposition to enhanced nitric oxide signaling is associated with reduced risks of coronary heart disease, peripheral arterial disease, and stroke.""?",False, +14786185,Nitric oxide disrupts Sepsis,3803,Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.,"Is the triple ""Nitric oxide disrupts Sepsis"" supported by the sentence: ""Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.""?",False, +12247489,Nitric oxide disrupts sickle cell anemia,3804,"Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.","Is the triple ""Nitric oxide disrupts sickle cell anemia"" supported by the sentence: ""Nitric oxide (NO) is inactivated in sickle cell disease (SCD), while bioavailability of arginine, the substrate for NO synthesis, is diminished.""?",False, +11088644,Nitric oxide disrupts cystic fibrosis,3805,"Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.","Is the triple ""Nitric oxide disrupts cystic fibrosis"" supported by the sentence: ""Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied.""?",False, +10963665,Nitric oxide disrupts neoplasm,3806,"Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.","Is the triple ""Nitric oxide disrupts neoplasm"" supported by the sentence: ""Inhibition of both tumor and host NOS activities, with an iNOS-selective inhibitor (1400W), a nonselective NOS inhibitor [Nomega-nitro-L-arginine methyl ester (L-NAME)], or scavenging NO with a ruthenium-based scavenger, significantly delayed tumor rejection, while having no appreciable effect on tumor growth.""?",False, +10158293,Nitric oxide disrupts myocardial ischemia,3807,"Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.","Is the triple ""Nitric oxide disrupts myocardial ischemia"" supported by the sentence: ""Our results demonstrate that myocardial ischemia and reperfusion upregulate the ET system, which is inhibited by NO.""?",False, +9091818,Nitric oxide disrupts respiratory failure,3808,"However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.","Is the triple ""Nitric oxide disrupts respiratory failure"" supported by the sentence: ""However, with advances in modes of mechanical ventilation, including high-frequency ventilation and the introduction of inhaled nitric oxide, the use and necessity for ECMO have clearly diminished for newborn respiratory failure.""?",False, +8577648,Nitric oxide disrupts Inflammation,3809,In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.,"Is the triple ""Nitric oxide disrupts Inflammation"" supported by the sentence: ""In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation.""?",False, +7822328,Nitric oxide disrupts adult acute respiratory distress syndrome,3810,BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).,"Is the triple ""Nitric oxide disrupts adult acute respiratory distress syndrome"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS).""?",False, +7750750,Nitric oxide disrupts myocardial infarction,3811,"Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.","Is the triple ""Nitric oxide disrupts myocardial infarction"" supported by the sentence: ""Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.""?",False, +7555296,Nitric oxide disrupts ischemia reperfusion injury,3812,NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.,"Is the triple ""Nitric oxide disrupts ischemia reperfusion injury"" supported by the sentence: ""NO inhibits the PMN-mediated reperfusion injury by direct effects on both the PMN and the vascular endothelium.""?",False, +7358959,Nitric oxide disrupts Hypoxemia,3813,CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.,"Is the triple ""Nitric oxide disrupts Hypoxemia"" supported by the sentence: ""CONCLUSIONS: These data indicate that NO decreases hypoxia-induced VEGF via a cGMP-dependent mechanism and suggest that NO may serve as an endogenous inhibitor of both hypoxia- and non- hypoxia-enhanced VEGF expression in vivo.""?",False, +26913950,Nitric oxide prevents adult acute respiratory distress syndrome,3814,"Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.","Is the triple ""Nitric oxide prevents adult acute respiratory distress syndrome"" supported by the sentence: ""Thus, inhaled NO reduces pulmonary hypertension in the severe adult respiratory distress syndrome and in persistent pulmonary hypertension of the newborn, and improves arterial oxygenation by redistributing pulmonary blood flow away from the shunt and towards areas with almost normal ventilation/perfusion ratios.""?",False, +25277893,Nitric oxide prevents neuralgia,3815,"Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.","Is the triple ""Nitric oxide prevents neuralgia"" supported by the sentence: ""Only H 2 O 2 and NO were evaluated as TRPV4 agonists, so one possible target to reduce neuropathic pain should focus on reducing these compounds.""?",False, +22898445,Nitric oxide prevents Infection,3816,The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.,"Is the triple ""Nitric oxide prevents Infection"" supported by the sentence: ""The endogenous biological signaling molecule nitric oxide (NO) is also a potential candidate for prevention of biomedical infections due to its antibiofilm activity.""?",False, +21669107,Nitric oxide prevents neoplasm,3817,"CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.","Is the triple ""Nitric oxide prevents neoplasm"" supported by the sentence: ""CRITICAL ISSUES: NO is a dual molecule which can have a tumor protecting or stimulating effect, depending on its local concentration.""?",False, +21628822,Nitric oxide prevents Hypoxemia,3818,"The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.","Is the triple ""Nitric oxide prevents Hypoxemia"" supported by the sentence: ""The result showed that NO level and cell-matrix adhesion of PBMNC were significantly reduced in hypoxia as compared with normoxia, as assessed by the DAF-FM and cell adhesion assay, respectively.""?",False, +21494876,Nitric oxide prevents Inflammation,3819,"This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.","Is the triple ""Nitric oxide prevents Inflammation"" supported by the sentence: ""This action increases shear stress (friction) to vascular endothelium that stimulates endothelial nitric oxide synthase (eNOS) to increase NO that decreases oxidative stress and inflammation, and, slows accelerated vascular ageing associated with opioids.""?",False, +21062009,Nitric oxide prevents pulmonary embolism,3820,"Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.","Is the triple ""Nitric oxide prevents pulmonary embolism"" supported by the sentence: ""Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group.""?",False, +16675253,Nitric oxide prevents stroke disorder,3821,"Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.","Is the triple ""Nitric oxide prevents stroke disorder"" supported by the sentence: ""Low levels of serum arginine and endothelium dysfunction have been reported in MELAS and this treatment may increase NO in endothelial cells and promote vasodilation, decreasing cerebral ischemia and strokes.""?",False, +13634130,Nitric oxide prevents sickle cell anemia,3822,"Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).","Is the triple ""Nitric oxide prevents sickle cell anemia"" supported by the sentence: ""Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu).""?",False, +11584828,Nitric oxide prevents brain ischemia,3823,"CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.","Is the triple ""Nitric oxide prevents brain ischemia"" supported by the sentence: ""CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.""?",False, +11450951,Nitric oxide prevents myocardial infarction,3824,BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.,"Is the triple ""Nitric oxide prevents myocardial infarction"" supported by the sentence: ""BACKGROUND: Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure.""?",False, +10887585,Nitric oxide prevents pneumonia,3825,"BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.","Is the triple ""Nitric oxide prevents pneumonia"" supported by the sentence: ""BACKGROUND: Inhaled nitric oxide improves gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.""?",False, +9990816,Nitric oxide prevents acute kidney failure,3826,"Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.","Is the triple ""Nitric oxide prevents acute kidney failure"" supported by the sentence: ""Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.""?",False, +9464831,Nitric oxide prevents myocardial ischemia,3827,We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.,"Is the triple ""Nitric oxide prevents myocardial ischemia"" supported by the sentence: ""We aimed to test the hypothesis that endogenous nitric oxide (NO) prevents myocardial ischemia in patients with LVH.""?",False, +8988568,Nitric oxide prevents chronic obstructive pulmonary disease,3828,Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).,"Is the triple ""Nitric oxide prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Both NO (patients: 23.42 +/- 1.67 microg/mL: controls: 40.0 +/- 3.38 microg/mL) and TM levels (patients: 5.46 +/- 1.32 ng/mL; controls: 12.9 +/- 0.51 ng/mL) were significantly decreased in COPD (p < 0.001).""?",False, +8396830,Nitric oxide prevents cystic fibrosis,3829,"Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.","Is the triple ""Nitric oxide prevents cystic fibrosis"" supported by the sentence: ""Sputum levels of nitrite (NO(2)(-)) and nitrate (NO(3)(-)), indicating local production of nitric oxide (NO. ), were not elevated but in fact were slightly reduced in CF.""?",False, +8224065,Nitric oxide prevents brain injury,3830,NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.,"Is the triple ""Nitric oxide prevents brain injury"" supported by the sentence: ""NO as an active vasodilatory and antithrombogenic agent may reduce cerebral damage in early ischemia.""?",False, +8045867,Nitric oxide prevents lung disorder,3831,These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.,"Is the triple ""Nitric oxide prevents lung disorder"" supported by the sentence: ""These later studies may indicate that inhaled NO can be applied to attenuate or prevent pulmonary artery disease in patients with injured lungs.""?",False, +7996843,Nitric oxide prevents Sepsis,3832,"One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.","Is the triple ""Nitric oxide prevents Sepsis"" supported by the sentence: ""One of the principal mediators of this control is nitric oxide; however, superoxide has recently been shown to be protective in systemic mycobacterial infections.""?",False, +7713281,Nitric oxide prevents respiratory failure,3833,Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.,"Is the triple ""Nitric oxide prevents respiratory failure"" supported by the sentence: ""Use of inhaled NO in early ALI did not alter mortality although it did reduce the frequency of severe respiratory failure in patients developing severe hypoxaemia.""?",False, +7103253,Nitric oxide prevents ischemia reperfusion injury,3834,It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.,"Is the triple ""Nitric oxide prevents ischemia reperfusion injury"" supported by the sentence: ""It is controversial whether nitric oxide (NO) is protective or deleterious against ischemia-reperfusion injury.""?",False, +27558971,Nitric oxide exacerbates myocardial ischemia,3835,Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.,"Is the triple ""Nitric oxide exacerbates myocardial ischemia"" supported by the sentence: ""Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.""?",False, +26883794,Nitric oxide exacerbates acute kidney failure,3836,Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.,"Is the triple ""Nitric oxide exacerbates acute kidney failure"" supported by the sentence: ""Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.""?",False, +24530593,Nitric oxide exacerbates ischemia reperfusion injury,3837,"NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.","Is the triple ""Nitric oxide exacerbates ischemia reperfusion injury"" supported by the sentence: ""NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI.""?",False, +23305196,Nitric oxide predisposes cystic fibrosis,3838,"It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.","Is the triple ""Nitric oxide predisposes cystic fibrosis"" supported by the sentence: ""It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods.""?",False, +18515843,Nitric oxide predisposes malaria,3839,"We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.","Is the triple ""Nitric oxide predisposes malaria"" supported by the sentence: ""We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.""?",False, +17339126,Nitric oxide predisposes stroke disorder,3840,"OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.","Is the triple ""Nitric oxide predisposes stroke disorder"" supported by the sentence: ""OBJECTIVES: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors.""?",False, +17303048,Nitric oxide predisposes brain ischemia,3841,"To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.","Is the triple ""Nitric oxide predisposes brain ischemia"" supported by the sentence: ""To ascertain the possible role of nitric oxide (NO) as risk factor for cerebral ischemia, we studied the serum levels of nitrate (oxidation product that provides an indirect estimation of NO), in 49 patients between the 3rd and 7th days after a cerebral ischemic event (TIAs, RIND and cerebral infarction) and in 65 matched controls.""?",False, +16438716,Nitric oxide predisposes respiratory system disorder,3842,Nitric oxide (NO) is now considered an important biomarker for respiratory disease.,"Is the triple ""Nitric oxide predisposes respiratory system disorder"" supported by the sentence: ""Nitric oxide (NO) is now considered an important biomarker for respiratory disease.""?",False, +16061041,Nitric oxide predisposes lung disorder,3843,"As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.","Is the triple ""Nitric oxide predisposes lung disorder"" supported by the sentence: ""As nitric oxide plays a role in a number of important physiological processes in the lung including host defense against pathogens such as Pseudomonas aeruginosa, inflammation and the regulation of vascular and broncho motor tone, the lack of nitric oxide may contribute to lung disease in cystic fibrosis patients.""?",False, +15696584,Nitric oxide predisposes chronic obstructive pulmonary disease,3844,"Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.","Is the triple ""Nitric oxide predisposes chronic obstructive pulmonary disease"" supported by the sentence: ""Patients with primary ciliary dyskinesia have very low concentration of nasal nitric oxide, which may contribute to the chronic upper airway diseases encountered by these patients.""?",False, +13236015,Nitric oxide predisposes bronchopulmonary dysplasia,3845,Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.,"Is the triple ""Nitric oxide predisposes bronchopulmonary dysplasia"" supported by the sentence: ""Later treatment with iNO based on the risk of BPD demonstrated no significant benefit for this outcome in our analysis.""?",False, +12163328,Nitric oxide predisposes acute kidney failure,3846,"However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).","Is the triple ""Nitric oxide predisposes acute kidney failure"" supported by the sentence: ""However, there is conflicting information (renoprotective or cytotoxic) as to the contribution of NO to ischemic acute renal failure (ARF).""?",False, +12068938,Nitric oxide predisposes neuralgia,3847,"During such processes, NO contributes to the development of neuropathic pain.","Is the triple ""Nitric oxide predisposes neuralgia"" supported by the sentence: ""During such processes, NO contributes to the development of neuropathic pain.""?",False, +11569688,Nitric oxide predisposes Premature birth,3848,CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.,"Is the triple ""Nitric oxide predisposes Premature birth"" supported by the sentence: ""CONCLUSION: This study has demonstrated great possibilities in the use of serum nitric oxide and cGMP levels as predictors of preterm delivery.""?",False, +9326529,Nitric oxide predisposes brain injury,3849,"Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.","Is the triple ""Nitric oxide predisposes brain injury"" supported by the sentence: ""Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury.""?",False, +8098085,Nitric oxide predisposes neoplasm,3850,These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.,"Is the triple ""Nitric oxide predisposes neoplasm"" supported by the sentence: ""These data indicate that nitric oxide contributes to the anti-tumor activity of IL-10 and that expression of iNOS in this context depends on IFN-gamma.""?",False, +7895713,Nitric oxide predisposes pneumonia,3851,"METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).","Is the triple ""Nitric oxide predisposes pneumonia"" supported by the sentence: ""METHODOLOGY: We studied a group of 44 hospital workers before and after routine influenza vaccination, using spirometry, and exhaled nitric oxide (eNO) as a marker of pulmonary inflammation (Group A).""?",False, +7863118,Nitric oxide predisposes Hypoxemia,3852,"CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.","Is the triple ""Nitric oxide predisposes Hypoxemia"" supported by the sentence: ""CONCLUSION(S): Vascular endothelial growth factor, NO and leptin appear to be markers of follicular hypoxia and suboptimal embryo development.""?",False, +7644760,Nitric oxide predisposes anemia,3853,"After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.","Is the triple ""Nitric oxide predisposes anemia"" supported by the sentence: ""After controlling for age and parasitemia, NO was no longer an independent predictor of anemia.""?",False, +7373094,Nitric oxide predisposes ischemia reperfusion injury,3854,Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.,"Is the triple ""Nitric oxide predisposes ischemia reperfusion injury"" supported by the sentence: ""Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.""?",False, +7119398,Nitric oxide predisposes Inflammation,3855,Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.,"Is the triple ""Nitric oxide predisposes Inflammation"" supported by the sentence: ""Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma.""?",False, +18948956,CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome,3856,"OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).","Is the triple ""CHORIOGONADOTROPIN ALFA related to ovarian hyperstimulation syndrome"" supported by the sentence: ""OHSS There was no evidence of a difference between rhCG and uhCG in the incidence of OHSS: moderate to severe OHSS (OR 1.76, 95% CI 0.37 to 8.45; 3 RCTs, N = 417, I(2) = 0%, low quality evidence), moderate OHSS (OR 0.78, 95% CI 0.27 to 2.27; 1 RCT, N = 243, I(2) = 0%, low quality evidence), mild to moderate OHSS (OR 1.00, 95% CI 0.42 to 2.38; 2 RCTs, N = 320, I(2) = 0%, low quality evidence) or undefined OHSS (OR 1.18, 95% CI 0.50 to 2.78; 3 RCTs, N = 495, I(2) = 0%, low quality evidence).""?",False, +10437081,CHORIONIC GONADOTROPIN related to hypogonadism,3857,[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].,"Is the triple ""CHORIONIC GONADOTROPIN related to hypogonadism"" supported by the sentence: ""[Increased production of androgens following administration of chorionic gonadotropins in hypogonadism].""?",False, +10427260,CHORIONIC GONADOTROPIN related to infertility disorder,3858,[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].,"Is the triple ""CHORIONIC GONADOTROPIN related to infertility disorder"" supported by the sentence: ""[Use of 10.000 U.I. of chorionic gonadotropins in feminine sterility].""?",False, +25953720,CHORIONIC GONADOTROPIN causes infertility disorder,3859,[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].,"Is the triple ""CHORIONIC GONADOTROPIN causes infertility disorder"" supported by the sentence: ""[Sterility in guinea pigs induced by chorionic gonadotropins. (Preliminary report)].""?",False, +12680602,CHORIONIC GONADOTROPIN causes Pregnancy,3860,Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.,"Is the triple ""CHORIONIC GONADOTROPIN causes Pregnancy"" supported by the sentence: ""Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.""?",False, +19382665,CHORIONIC GONADOTROPIN affects Pregnancy,3861,"Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.","Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Early in pregnancy, NETosis is enhanced by chorionic gonadotropin, whereas toward term is stimulated by estrogen.""?",False, +10661395,CHORIONIC GONADOTROPIN affects Pregnancy,3862,Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.,"Is the triple ""CHORIONIC GONADOTROPIN affects Pregnancy"" supported by the sentence: ""Effect of Orga-Steron (methyloestrenolon) on the production of chorionic gonadotropin in early pregnancy.""?",False, +11878666,CHORIONIC GONADOTROPIN produces Pregnancy,3863,Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.,"Is the triple ""CHORIONIC GONADOTROPIN produces Pregnancy"" supported by the sentence: ""Characteristic for human pregnancy is the production of the glycoprotein chorionic gonadotropin (hCG) hormone.""?",False, +19257969,Triclosan causes allergic disease,3864,Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.,"Is the triple ""Triclosan causes allergic disease"" supported by the sentence: ""Results from epidemiological studies on the effect of TCS on human health have implicated the compound as responsible for certain allergies and reproductive defects.""?",False, +17886883,Triclosan affects gingivitis,3865,A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.,"Is the triple ""Triclosan affects gingivitis"" supported by the sentence: ""A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days.""?",False, +9651026,Triclosan disrupts gingivitis,3866,"It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.","Is the triple ""Triclosan disrupts gingivitis"" supported by the sentence: ""It is concluded that dentifrice products containing triclosan do not possess sufficient antimicrobial activity to suppress plaque and gingivitis development in the absence of normal oral hygiene, and that relative to chlorhexidine, triclosan itself offers only modest efficacy for the prevention of plaque accumulation and therefore the delayed onset of gingivitis.""?",False, +16053270,Triclosan prevents allergic disease,3867,"Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.","Is the triple ""Triclosan prevents allergic disease"" supported by the sentence: ""Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study.""?",False, +20585436,Povidone iodine affects stomatitis,3868,"Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.","Is the triple ""Povidone iodine affects stomatitis"" supported by the sentence: ""Conclusion: We found that addition of amphotericin B and chlorhexidine, to the nystatin and povidone iodine resulted in a significant beneficial effect in prevention OM.""?",False, +22182083,Povidone iodine prevents Infection,3869,"Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.","Is the triple ""Povidone iodine prevents Infection"" supported by the sentence: ""Overall, these qualities of PVP-I make it a useful alternative decolonizing agent for the prevention of S. aureus infections, but additional experimental and clinical data are required to further evaluate the use of PVP-I in this setting.""?",False, +22061199,Povidone iodine prevents dental caries,3870,"OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.","Is the triple ""Povidone iodine prevents dental caries"" supported by the sentence: ""OBJECTIVES: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.""?",False, +20053240,Povidone iodine prevents keratitis,3871,"The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.","Is the triple ""Povidone iodine prevents keratitis"" supported by the sentence: ""The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.""?",False, +25268747,Vinblastine related to acute myeloid leukemia,3872,Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.,"Is the triple ""Vinblastine related to acute myeloid leukemia"" supported by the sentence: ""Vinblastine as a bridge to 7 + 3 in acute myeloid leukaemia.""?",False, +24601120,Vinblastine related to leukemia,3873,Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.,"Is the triple ""Vinblastine related to leukemia"" supported by the sentence: ""Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems.""?",False, +17518639,Vinblastine related to testicular cancer,3874,"Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.","Is the triple ""Vinblastine related to testicular cancer"" supported by the sentence: ""Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination with cisplatin.""?",False, +11295996,Vinblastine related to melanoma,3875,"The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.","Is the triple ""Vinblastine related to melanoma"" supported by the sentence: ""The results of this study suggest that V-LEU was as active as vinblastine in most tumour lines, exhibiting superior antitumour activity in malignant melanoma, SCLC and breast cancer lines.""?",False, +10629211,Vinblastine related to castration-resistant prostate carcinoma,3876,CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.,"Is the triple ""Vinblastine related to castration-resistant prostate carcinoma"" supported by the sentence: ""CONCLUSION: We conclude that EMP and vinblastine is an active combination in hormone-refractory prostate cancer.""?",False, +9405598,Vinblastine related to glioma,3877,The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.,"Is the triple ""Vinblastine related to glioma"" supported by the sentence: ""The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.""?",False, +8887641,Vinblastine related to neoplasm,3878,"Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.","Is the triple ""Vinblastine related to neoplasm"" supported by the sentence: ""Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no.""?",False, +8831546,Vinblastine related to renal cell carcinoma,3879,Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.,"Is the triple ""Vinblastine related to renal cell carcinoma"" supported by the sentence: ""Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma: a phase II study.""?",False, +8248825,Vinblastine related to lymphoma,3880,"OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.","Is the triple ""Vinblastine related to lymphoma"" supported by the sentence: ""OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprotein (P-gp) with an average EC50 of 0.032 microM.""?",False, +8201846,Vinblastine related to Langerhans cell histiocytosis,3881,[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].,"Is the triple ""Vinblastine related to Langerhans cell histiocytosis"" supported by the sentence: ""[Treatment of generalized form of histiocytosis X in children with vinblastine and prednisone].""?",False, +7111310,Vinblastine related to Hodgkins lymphoma,3882,"The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.","Is the triple ""Vinblastine related to Hodgkins lymphoma"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy in advanced Hodgkin's disease.""?",False, +22913920,Vinblastine causes neoplasm,3883,"Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.","Is the triple ""Vinblastine causes neoplasm"" supported by the sentence: ""Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.""?",False, +14498052,Vinblastine affects Langerhans cell histiocytosis,3884,"Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.","Is the triple ""Vinblastine affects Langerhans cell histiocytosis"" supported by the sentence: ""Non-Langerhans' cell histiocytosis synovial involvements responded poorly to vinblastine and corticosteroids, while Langerhans' cell histiocytosis involvements responded completely but transiently.""?",False, +12889760,Vinblastine affects renal cell carcinoma,3885,"In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.","Is the triple ""Vinblastine affects renal cell carcinoma"" supported by the sentence: ""In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment.""?",False, +11723511,Vinblastine affects neoplasm,3886,"By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.","Is the triple ""Vinblastine affects neoplasm"" supported by the sentence: ""By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.""?",False, +19032862,Vinblastine disrupts neoplasm,3887,We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.,"Is the triple ""Vinblastine disrupts neoplasm"" supported by the sentence: ""We further demonstrated that the growth of pemetrexed-resistant tumors could be inhibited by vinblastine in vivo and vincristine in vitro.""?",False, +26195658,Desacetylvinblastine amide related to lymphoma,3888,Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.,"Is the triple ""Desacetylvinblastine amide related to lymphoma"" supported by the sentence: ""Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.""?",False, +26116904,Desacetylvinblastine amide related to acute lymphoblastic leukemia,3889,"Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.","Is the triple ""Desacetylvinblastine amide related to acute lymphoblastic leukemia"" supported by the sentence: ""Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.""?",False, +25980030,Desacetylvinblastine amide related to small cell lung carcinoma,3890,"Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.","Is the triple ""Desacetylvinblastine amide related to small cell lung carcinoma"" supported by the sentence: ""Phase II study of vindesine, cisplatin, and hexamethylmelamine (VCH) in small cell carcinoma of the lung.""?",False, +26313629,Desacetylvinblastine amide affects neoplasm,3891,Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).,"Is the triple ""Desacetylvinblastine amide affects neoplasm"" supported by the sentence: ""Vindesine is a recent vinca alkaloid derivative with anti-tumor effects shown in in vitro systems and in patients with acute lymphocytic leukemia (ALL).""?",False, +26201212,Desacetylvinblastine amide affects acute lymphoblastic leukemia,3892,A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.,"Is the triple ""Desacetylvinblastine amide affects acute lymphoblastic leukemia"" supported by the sentence: ""A schedule of sequential of methotrexate and vindesine was developed which showed effect in acute lymphoblastic leukemia in children in relapse and which was relatively nontoxic.""?",False, +26302410,Desacetylvinblastine amide prevents neoplasm,3893,"No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.","Is the triple ""Desacetylvinblastine amide prevents neoplasm"" supported by the sentence: ""No patient responded to vindesine alone, but about one-fourth achieved significant tumor reductions from intermittent high-dose prednisone, either alone or in combination with vindesine.""?",False, +25951740,Diazoxide causes hyperinsulinism,3894,"[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].","Is the triple ""Diazoxide causes hyperinsulinism"" supported by the sentence: ""[Histoenzymatic research on the adipocytes of rats with hyperNEFA-emia, hyperinsulinism or diazoxide-induced diabetes].""?",False, +17059197,Diazoxide causes hypoglycemia,3895,CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.,"Is the triple ""Diazoxide causes hypoglycemia"" supported by the sentence: ""CONCLUSION: We report for the first time that diazoxide can cause paradoxical hypoglycaemia when used in moderate to high doses in infants with HH.""?",False, +25817473,Diazoxide affects hypertensive disorder,3896,The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.,"Is the triple ""Diazoxide affects hypertensive disorder"" supported by the sentence: ""The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.""?",False, +20202762,Diazoxide affects obesity disorder,3897,"Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.","Is the triple ""Diazoxide affects obesity disorder"" supported by the sentence: ""Treatment with diazoxide partially normalizes obesity in children and adults with PWS and in a PWS mouse model, demonstrating that the biological pathways impacted by diazoxide may be rational pharmacological targets in PWS and other disorders diseases associated with obesity.""?",False, +11393233,Diazoxide affects hyperinsulinism,3898,Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).,"Is the triple ""Diazoxide affects hyperinsulinism"" supported by the sentence: ""Recently diagnosed family members showed a dominantly transmitted pattern of diazoxide-responsive hyperinsulinism (HI).""?",False, +8184004,Diazoxide affects hypoglycemia,3899,"An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.","Is the triple ""Diazoxide affects hypoglycemia"" supported by the sentence: ""An activating mutation in the ""glucose sensor"" glucokinase has recently been reported in one family with diazoxide-responsive autosomal dominant hyperinsulinemic hypoglycemia.""?",False, +9572369,Diazoxide disrupts hyperinsulinism,3900,"CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.","Is the triple ""Diazoxide disrupts hyperinsulinism"" supported by the sentence: ""CONCLUSIONS: Chronic suppression of hyperinsulinemia in obese Zucker rats by DZ decreased the activities of key enzymes regulating hepatic gluconeogenesis, implying that attenuation of the hyperinsulinemic state by DZ may be therapeutically beneficial.""?",False, +26286810,Diazoxide prevents hypoglycemia,3901,Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.,"Is the triple ""Diazoxide prevents hypoglycemia"" supported by the sentence: ""Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.""?",False, +22404640,Diazoxide prevents hypertensive disorder,3902,Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.,"Is the triple ""Diazoxide prevents hypertensive disorder"" supported by the sentence: ""Diazoxide is given by rapid intravenous injection for the urgent reduction of high blood pressure in patients with all grades of renal function.""?",False, +19200973,Diazoxide prevents obesity disorder,3903,OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.,"Is the triple ""Diazoxide prevents obesity disorder"" supported by the sentence: ""OBJECTIVE: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.""?",False, +16737667,Diazoxide predisposes hypoglycemia,3904,Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.,"Is the triple ""Diazoxide predisposes hypoglycemia"" supported by the sentence: ""Normoglycaemia on diazoxide <5 mg/kg/day was a safe predictor of resolved HH.""?",False, +14267417,Pantoprazole affects gastroesophageal reflux disease,3905,Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).,"Is the triple ""Pantoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).""?",False, +12160514,Pantoprazole prevents active peptic ulcer disease,3906,"Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.","Is the triple ""Pantoprazole prevents active peptic ulcer disease"" supported by the sentence: ""Standard delayed-release proton-pump inhibitors have not been extensively studied in this patient group, but there are some data to support their efficacy in increasing intragastric pH, and in the case of intravenous pantoprazole in preventing gastrointestinal bleeding.""?",False, +8423273,Pantoprazole prevents peptic ulcer disease,3907,"Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.","Is the triple ""Pantoprazole prevents peptic ulcer disease"" supported by the sentence: ""Efficacy of pantoprazole in the prevention of peptic ulcers, induced by non-steroidal anti-inflammatory drugs: a prospective, placebo-controlled, double-blind, parallel-group study.""?",False, +7509578,Pantoprazole prevents ulcer disease,3908,"In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.","Is the triple ""Pantoprazole prevents ulcer disease"" supported by the sentence: ""In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e.g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e.g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e.g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.""?",False, +21088628,Pantoprazole predisposes active peptic ulcer disease,3909,"Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.","Is the triple ""Pantoprazole predisposes active peptic ulcer disease"" supported by the sentence: ""Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA.""?",False, +20047688,Lansoprazole causes gastric ulcer,3910,"AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.","Is the triple ""Lansoprazole causes gastric ulcer"" supported by the sentence: ""AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats.""?",False, +26544602,Lansoprazole affects peptic ulcer disease,3911,Effect of lansoprazole on peptic ulcers.,"Is the triple ""Lansoprazole affects peptic ulcer disease"" supported by the sentence: ""Effect of lansoprazole on peptic ulcers.""?",False, +11547923,Lansoprazole affects gastroesophageal reflux disease,3912,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Lansoprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, +10008124,Lansoprazole affects peptic esophagitis,3913,"When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.","Is the triple ""Lansoprazole affects peptic esophagitis"" supported by the sentence: ""When data were analysed according to baseline Los Angeles grade classification, esomeprazole, 20 mg once daily, achieved consistently higher remission rates across all grades of disease severity, whereas the efficacy of lansoprazole decreased to a greater extent with increasing severity of reflux oesophagitis.""?",False, +7314434,Lansoprazole affects Helicobacter pylori infectious disease,3914,"Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.","Is the triple ""Lansoprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.""?",False, +9466998,Lansoprazole disrupts gastroesophageal reflux disease,3915,"In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).","Is the triple ""Lansoprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).""?",False, +20033093,Lansoprazole prevents peptic ulcer disease,3916,"CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.","Is the triple ""Lansoprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Vonoprazan (10 and 20 mg) was as effective as lansoprazole (15 mg) in preventing peptic ulcer recurrence during LDA therapy, had a similar long-term safety profile and was well tolerated.""?",False, +15339719,Lansoprazole prevents duodenal ulcer,3917,"The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.","Is the triple ""Lansoprazole prevents duodenal ulcer"" supported by the sentence: ""The results of this study have demonstrated that although lansoprazole, PD-136450 and ranitidine were protective against CRS-induced gastric ulcers, the antiulcer activities of PD-136450 and ranitidine involved both PG and nitric oxide pathways, while lansoprazole acted independently of these two systems during CRS.""?",False, +9335785,Lansoprazole prevents gastric ulcer,3918,"CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.","Is the triple ""Lansoprazole prevents gastric ulcer"" supported by the sentence: ""CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d.""?",False, +8183428,Lansoprazole prevents gastroesophageal reflux disease,3919,"In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.","Is the triple ""Lansoprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""In direct comparisons, lansoprazole alone (not combined with antibiotics) proves to be equieffective to other PPI and more effective than H2-RA in both therapy and prevention of GERD, peptic ulcer (a part from anti-Hp regimens) and NSAID-induced ulcer.""?",False, +27664803,Lansoprazole exacerbates gastritis,3920,RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.,"Is the triple ""Lansoprazole exacerbates gastritis"" supported by the sentence: ""RESULTS: Lansoprazole and ranitidine led to a significant aggravation of gastritis in the corpus after 6 and 12 months of treatment.""?",False, +10008126,Lansoprazole predisposes gastroesophageal reflux disease,3921,AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.,"Is the triple ""Lansoprazole predisposes gastroesophageal reflux disease"" supported by the sentence: ""AIM: To determine whether symptomatic response to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain.""?",False, +10345128,Omeprazole subclass of Omeprazole sulfone,3922,"The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.","Is the triple ""Omeprazole subclass of Omeprazole sulfone"" supported by the sentence: ""The experimentally determined values of LOD (microg ml(-1)) were 1.126; 0.76; 0.691 and 0.716 for OM, OMS, PANa and NPA, respectively.""?",False, +8512321,Omeprazole subclass of Hydroxyomeprazole,3923,"The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.","Is the triple ""Omeprazole subclass of Hydroxyomeprazole"" supported by the sentence: ""The kinetics of 5-hydroxyomeprazole (5-OH-OP) formation was best described by the two-enzyme and single-enzyme Michaelis-Menten equations for liver microsomes from CYP2C19 extensive (EMs) and poor metabolizers, respectively.""?",False, +27115212,Omeprazole related to Omeprazole sulfone,3924,"Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.","Is the triple ""Omeprazole related to Omeprazole sulfone"" supported by the sentence: ""Comparing the omeprazole doses of 40 mg and 60 mg in eight EMs on day 7 of treatment showed that CYP2C19-dependent plasma clearance of omeprazole and omeprazole sulfone was reduced from 19.0 to 8.4 L/h (P < .001) and from 19.8 to 9.2 L/h (P = .012), respectively.""?",False, +12365583,Omeprazole related to gastric ulcer,3925,Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?,"Is the triple ""Omeprazole related to gastric ulcer"" supported by the sentence: ""Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?""?",False, +7744216,Omeprazole related to Hydroxyomeprazole,3926,"Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.","Is the triple ""Omeprazole related to Hydroxyomeprazole"" supported by the sentence: ""Formulation had no effect on the ratio of omeprazole to 5'-hydroxyomeprazole, which was higher than previously reported with single 20 mg doses of omeprazole.""?",False, +26722672,Omeprazole physically interacts with Omeprazole sulfone,3927,"The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.","Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone.""?",False, +9932953,Omeprazole physically interacts with Hydroxyomeprazole,3928,"Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).","Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""Omeprazole is metabolized to two major metabolites, 5-hydroxyomeprazole (CYP2C19) and omeprazole sulfone (CYP3A4).""?",False, +22198908,Omeprazole physically interacts with Omeprazole sulfone,3929,Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.,"Is the triple ""Omeprazole physically interacts with Omeprazole sulfone"" supported by the sentence: ""Mass-spectrometry analysis of omeprazole sulfone as a CYP3A4-mediated metabolite demonstrated the absence of erythromycin influence on CYP3A4-dependent omeprazole metabolism.""?",False, +13085286,Omeprazole physically interacts with Hydroxyomeprazole,3930,The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.,"Is the triple ""Omeprazole physically interacts with Hydroxyomeprazole"" supported by the sentence: ""The plasma concentrations of omeprazole and 5-hydroxyomeprazole were assayed by reversed-phase high-performance liquid chromatography and the omeprazole hydroxylation index (HI) was determined.""?",False, +27703677,Omeprazole causes anemia,3931,"Pyrexia, anaemia and acute renal failure secondary to omeprazole.","Is the triple ""Omeprazole causes anemia"" supported by the sentence: ""Pyrexia, anaemia and acute renal failure secondary to omeprazole.""?",False, +27298440,Omeprazole causes Hemorrhage,3932,"Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.","Is the triple ""Omeprazole causes Hemorrhage"" supported by the sentence: ""Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding.""?",False, +24514538,Omeprazole causes peptic ulcer disease,3933,Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.,"Is the triple ""Omeprazole causes peptic ulcer disease"" supported by the sentence: ""Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.""?",False, +19641302,Omeprazole causes gastroesophageal reflux disease,3934,"The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.","Is the triple ""Omeprazole causes gastroesophageal reflux disease"" supported by the sentence: ""The whole plant extract of E. hirta in doses of 50, 100, and 200 mg/kg were administered orally twice daily at 10:00 and 16:00 hours, respectively, for 5 days and kaempferol (100 mg/kg) or omeprazole (OMZ) in the dose of 30 mg/kg 1 hour prior to the induction of GERD.""?",False, +15956000,Omeprazole causes esophagitis,3935,"Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.","Is the triple ""Omeprazole causes esophagitis"" supported by the sentence: ""Celecoxib (COX-2 blocker; 10 mg/kg), 16,16-dimethyl prostaglandinE(2) (dmPGE(2); a synthetic analogue of PGE(2) ; 10 ug/kg), melatonin (20 and 40 mg/kg) and omeprazole (10 mg/kg) were given intra-peritoneally 45 min before induction of oesophagitis in rats.""?",False, +12187782,Omeprazole causes ulcer disease,3936,"Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.","Is the triple ""Omeprazole causes ulcer disease"" supported by the sentence: ""Rats were gavaged for 14 days with saline, omeprazole and muscovite starting 3 days after ulcer induction.""?",False, +11135889,Omeprazole causes injury,3937,"DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.","Is the triple ""Omeprazole causes injury"" supported by the sentence: ""DISCUSSION: Five cases of omeprazole-induced liver injury have been reported to the Swiss Drug Regulatory Agency since 1990, among them two of cholestatic hepatitis and one of hepatic failure.""?",False, +10813876,Omeprazole causes Cough,3938,Omeprazole-induced intractable cough.,"Is the triple ""Omeprazole causes Cough"" supported by the sentence: ""Omeprazole-induced intractable cough.""?",False, +8871402,Omeprazole causes gastric ulcer,3939,"Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.","Is the triple ""Omeprazole causes gastric ulcer"" supported by the sentence: ""Cimetidine, omeprazole or atropine were administered intraperitoneally at doses of 200, 5 and 1 mg/kg, respectively, after EAGU induction.""?",False, +7272148,Omeprazole causes duodenal ulcer,3940,"Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.","Is the triple ""Omeprazole causes duodenal ulcer"" supported by the sentence: ""Likewise, pantoprazole showed the healing promoting action on chronic duodenal ulcers induced by acetic acid, and this effect was also more potent when compared to omeprazole or lansoprazole.""?",False, +27758339,Omeprazole affects Zollinger-Ellison syndrome,3941,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects Zollinger-Ellison syndrome"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, +27758338,Omeprazole affects peptic ulcer disease,3942,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, +27758337,Omeprazole affects peptic esophagitis,3943,"Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.","Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""Omeprazole has been used with increasing frequency for the treatment of conditions such as reflux oesophagitis, peptic ulcer disease, and Zollinger-Ellison syndrome.""?",False, +27733079,Omeprazole affects peptic esophagitis,3944,The effect of treating reflux oesophagitis with omeprazole on quality of life.,"Is the triple ""Omeprazole affects peptic esophagitis"" supported by the sentence: ""The effect of treating reflux oesophagitis with omeprazole on quality of life.""?",False, +27346919,Omeprazole affects peptic ulcer disease,3945,[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].,"Is the triple ""Omeprazole affects peptic ulcer disease"" supported by the sentence: ""[What is the current therapeutic role of omeprazole in gastroduodenal ulcer disease?].""?",False, +22440533,Omeprazole affects anemia,3946,Prolonged use of omeprazole may involve in inducing anemia.,"Is the triple ""Omeprazole affects anemia"" supported by the sentence: ""Prolonged use of omeprazole may involve in inducing anemia.""?",False, +18634760,Omeprazole affects Pain,3947,"Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.","Is the triple ""Omeprazole affects Pain"" supported by the sentence: ""Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor.""?",False, +17967745,Omeprazole affects injury,3948,Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.,"Is the triple ""Omeprazole affects injury"" supported by the sentence: ""Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy.""?",False, +12114858,Omeprazole affects ulcer disease,3949,"Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.""?",False, +11576921,Omeprazole affects Hydroxyomeprazole,3950,CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""CONCLUSION: Our results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.""?",False, +10321262,Omeprazole affects duodenal ulcer,3951,"46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.","Is the triple ""Omeprazole affects duodenal ulcer"" supported by the sentence: ""46 patients having exacerbation of duodenal ulcer in the presence of Helicobacter pylori (HP) were studied for efficacy of HP eradication treatment which comprised omeprazole (40 mg/day), colloid bismuth subcitrate (480 mg/day) and metronidazole (1000 mg/day) for 2 weeks.""?",False, +9976497,Omeprazole affects gastric ulcer,3952,A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.,"Is the triple ""Omeprazole affects gastric ulcer"" supported by the sentence: ""A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.""?",False, +8694897,Omeprazole affects Helicobacter pylori infectious disease,3953,"The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.","Is the triple ""Omeprazole affects Helicobacter pylori infectious disease"" supported by the sentence: ""The effect of triple therapy with omeprazole, amoxycillin and tinidazole on Hp infection and ulcer healing was also determined.""?",False, +8349380,Omeprazole affects Hemorrhage,3954,"CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.","Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.""?",False, +8349375,Omeprazole affects Hemorrhage,3955,Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Omeprazole affects Hemorrhage"" supported by the sentence: ""Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, +7653505,Omeprazole affects gastroesophageal reflux disease,3956,The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.,"Is the triple ""Omeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise.""?",False, +7572363,Omeprazole affects ulcer disease,3957,"Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".","Is the triple ""Omeprazole affects ulcer disease"" supported by the sentence: ""Four-week administration of sucralfate also extensively reduced the size of the ""unhealed ulcers"", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on ""unhealed ulcers"".""?",False, +14345083,Omeprazole affects Hydroxyomeprazole,3958,The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.,"Is the triple ""Omeprazole affects Hydroxyomeprazole"" supported by the sentence: ""The AUC(0-infinity) ratios of omeprazole to 5-hydroxyomeprazole increase by 74.98% +/- 35.48% (P = .001) and those of omeprazole to omeprazole sulfone do not change significantly (P = .832) in CYP2C19*1/*1.""?",False, +26726289,Omeprazole disrupts gastroesophageal reflux disease,3959,"A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.","Is the triple ""Omeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis.""?",False, +26000029,Omeprazole disrupts Zollinger-Ellison syndrome,3960,Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.,"Is the triple ""Omeprazole disrupts Zollinger-Ellison syndrome"" supported by the sentence: ""Reduction of gastric hypersecretion in Zollinger-Ellison syndrome with omeprazole.""?",False, +20129793,Omeprazole disrupts Barrett esophagus,3961,"Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.","Is the triple ""Omeprazole disrupts Barrett esophagus"" supported by the sentence: ""Here, we investigated whether omeprazole could inhibit BE progression by regulating Hh pathway and explored the promising Hh-targeted miRNAs in BE cells.""?",False, +19299462,Omeprazole disrupts active peptic ulcer disease,3962,"The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.","Is the triple ""Omeprazole disrupts active peptic ulcer disease"" supported by the sentence: ""The only randomized clinical trial assessing the clinical relevance of clopidogrel-omeprazole interaction showed that the use of omeprazole was associated with a reduction in GI bleeding, without any differences in CV outcomes.""?",False, +15524012,Omeprazole disrupts peptic ulcer disease,3963,Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.,"Is the triple ""Omeprazole disrupts peptic ulcer disease"" supported by the sentence: ""Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients.""?",False, +13078646,Omeprazole disrupts ulcer disease,3964,"The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.","Is the triple ""Omeprazole disrupts ulcer disease"" supported by the sentence: ""The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups.""?",False, +10891179,Omeprazole disrupts gastric ulcer,3965,"POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.","Is the triple ""Omeprazole disrupts gastric ulcer"" supported by the sentence: ""POTENTIAL RELEVANCE: Optimal timing for daily dosing of athletic horses with an effective OME preparation, in order to suppress gastric squamous ulceration, might be 4-8 h prior to a training session.""?",False, +10776897,Omeprazole disrupts duodenal ulcer,3966,"(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.","Is the triple ""Omeprazole disrupts duodenal ulcer"" supported by the sentence: ""(ii) Antiulcer effect under normal conditions or following gastrectomy: in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers, acting through gastric acid-independent mechanisms.""?",False, +8884340,Omeprazole disrupts esophagitis,3967,"The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).","Is the triple ""Omeprazole disrupts esophagitis"" supported by the sentence: ""The ED50 values of IY81149 for inhibition of oesophagitis and volume of gastric secretion were lower than of omeprazole (5.7 vs. 14.2 micromol, 15.3 vs. 24.0 micromol, respectively).""?",False, +27690262,Omeprazole prevents Helicobacter pylori infectious disease,3968,"To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.","Is the triple ""Omeprazole prevents Helicobacter pylori infectious disease"" supported by the sentence: ""To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial.""?",False, +27025148,Omeprazole prevents Cough,3969,"Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.","Is the triple ""Omeprazole prevents Cough"" supported by the sentence: ""Omeprazole did not give any significant relief of cough, whereas patients who were operated on with fundoplication and crural repair showed a highly significant reduction of cough and bronchitis.""?",False, +26715213,Omeprazole prevents Pain,3970,Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.,"Is the triple ""Omeprazole prevents Pain"" supported by the sentence: ""Concurrent administration of omeprazole reduces ulcer pain more rapidly but has no effect on ulcer healing.""?",False, +16929638,Omeprazole prevents esophagitis,3971,"Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.","Is the triple ""Omeprazole prevents esophagitis"" supported by the sentence: ""Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects.""?",False, +15601042,Omeprazole prevents active peptic ulcer disease,3972,Omeprazole even can decrease gastro-intestinal bleeding in those patients.,"Is the triple ""Omeprazole prevents active peptic ulcer disease"" supported by the sentence: ""Omeprazole even can decrease gastro-intestinal bleeding in those patients.""?",False, +9292674,Omeprazole prevents peptic ulcer disease,3973,"CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.","Is the triple ""Omeprazole prevents peptic ulcer disease"" supported by the sentence: ""CONCLUSION: Under the defined tolerance limits, the regular dose of omeprazole is as successful as a high dose in preventing peptic ulcer rebleeding.""?",False, +8884338,Omeprazole prevents peptic esophagitis,3974,IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.,"Is the triple ""Omeprazole prevents peptic esophagitis"" supported by the sentence: ""IY81149 and omeprazole significantly prevented the development of reflux oesophagitis and gastric secretion in a dose-dependent manner.""?",False, +8341772,Omeprazole prevents duodenal ulcer,3975,The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].,"Is the triple ""Omeprazole prevents duodenal ulcer"" supported by the sentence: ""The most consistent effect was seen with omeprazole for both duodenal ulcer prevention (OR [95% CI] = 0.12 [0.06-0.23]) and gastric ulcer prevention (OR = 0.20 [0.13-0.31)].""?",False, +8169375,Omeprazole prevents injury,3976,"The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).","Is the triple ""Omeprazole prevents injury"" supported by the sentence: ""The morphometric analysis of gastric histological sections revealed that pantoprazole and omeprazole dose-dependently prevented the necrotic mucosal injury evoked by ethanol-HCl (ED50 = 14.1 and 21.6 micromol/kg, respectively).""?",False, +7646984,Omeprazole prevents gastric ulcer,3977,Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.,"Is the triple ""Omeprazole prevents gastric ulcer"" supported by the sentence: ""Omeprazole when compared to misoprostol was equally effective in preventing gastric ulcers and more effective in duodenal ulcers.""?",False, +7653510,Omeprazole prevents gastroesophageal reflux disease,3978,"CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.","Is the triple ""Omeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Running-induced acid reflux, but not symptoms, were decreased by omeprazole, probably because most symptoms were not related to acid reflux.""?",False, +7332307,Omeprazole prevents ulcer disease,3979,Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.,"Is the triple ""Omeprazole prevents ulcer disease"" supported by the sentence: ""Studies comparing omeprazole to misoprostol or ranitidine for nonsteroidal anti-inflammatory drug (NSAID) ulcer prevention in true NSAID ulcers have shown that omeprazole is equal to full-dose misoprostol for ulcer healing and to the lowest useful dose of misoprostol for ulcer prevention.""?",False, +24752030,Omeprazole predisposes type 2 diabetes mellitus,3980,"Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.","Is the triple ""Omeprazole predisposes type 2 diabetes mellitus"" supported by the sentence: ""Subgroup analysis of individual PPI showed that pantoprazole (OR: 1.14, 95% CI: 1.07-1.21), lansoprazole (OR: 1.08, 95% CI: 1.03-1.12), and omeprazole (OR: 1.11, 95% CI: 1.06-1.16) have a significantly higher risk of T2DM development.""?",False, +21309680,Omeprazole predisposes melanoma,3981,"The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.","Is the triple ""Omeprazole predisposes melanoma"" supported by the sentence: ""The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk.""?",False, +20838741,Omeprazole predisposes Barrett esophagus,3982,"Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.","Is the triple ""Omeprazole predisposes Barrett esophagus"" supported by the sentence: ""Here, we explored the role of omeprazole on Hh signaling and expression of two crucial biomarkers of BE, SOX9 and CDX2.""?",False, +12649375,Rabeprazole affects infectious disease,3983,"METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).","Is the triple ""Rabeprazole affects infectious disease"" supported by the sentence: ""METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).""?",False, +11547924,Rabeprazole affects gastroesophageal reflux disease,3984,"While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.","Is the triple ""Rabeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""While antacids and histamine H(2)-receptor antagonists have a role in treating mild GERD, effective relief of many cases of oesophagitis is usually only achieved by using proton-pump inhibitors such as lansoprazole, omeprazole and rabeprazole.""?",False, +15461842,Rabeprazole disrupts gastroesophageal reflux disease,3985,CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.,"Is the triple ""Rabeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Administration of 5 mg and 10 mg rabeprazole sufficiently inhibited pathological gastroesophageal acid reflux and relieved heartburn episodes in NERD patients who did not respond to an antacid.""?",False, +16244495,Rabeprazole prevents peptic ulcer disease,3986,"We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.","Is the triple ""Rabeprazole prevents peptic ulcer disease"" supported by the sentence: ""We aimed to clarify the efficacy of rabeprazole for preventing peptic ulcer, esophagitis, and gastrointestinal symptoms associated with LDA.""?",False, +15354267,Rabeprazole prevents active peptic ulcer disease,3987,The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.,"Is the triple ""Rabeprazole prevents active peptic ulcer disease"" supported by the sentence: ""The effect of rabeprazole to prevent GI bleeding is limited in patients receiving DAT.""?",False, +8397732,Rabeprazole prevents gastroesophageal reflux disease,3988,RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).,"Is the triple ""Rabeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""RESULTS: Both rabeprazole doses were significantly more effective than placebo in preventing endoscopically demonstrable GORD relapse (P<0.001 versus placebo).""?",False, +23526790,Esomeprazole causes active peptic ulcer disease,3989,"Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.","Is the triple ""Esomeprazole causes active peptic ulcer disease"" supported by the sentence: ""Furthermore, we have identified a novel and potentially hepatotoxic interaction that might occur during concomitant use of meloxicam and esomeprazole, which are commonly prescribed together to allay NSAID-induced gastrointestinal (GI) bleeding.""?",False, +20333475,Esomeprazole causes preeclampsia,3990,We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.,"Is the triple ""Esomeprazole causes preeclampsia"" supported by the sentence: ""We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.""?",False, +15271081,Esomeprazole causes gastric ulcer,3991,The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.,"Is the triple ""Esomeprazole causes gastric ulcer"" supported by the sentence: ""The healing activity of esomeprazole on indomethacin-induced gastric ulcerations can be ascribed to two mechanisms: (1) acid-dependent reduction of pro-apoptotic signalling; (2) acid-independent restoration of proliferating/repairing pathways.""?",False, +22638872,Esomeprazole affects neoplasm,3992,"Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.","Is the triple ""Esomeprazole affects neoplasm"" supported by the sentence: ""Subsequently, the interactions of microtubule-associated protein 2 (MAP2), homeodomain-interacting protein kinase 2 (HIPK2) and ankyrin 2 (ANK2) were noted in a competing endogenous RNA (ceRNA) network, which may be important targets of ESO, exerting an anti-tumor effect in AGS cells.""?",False, +20180848,Esomeprazole affects preeclampsia,3993,Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.,"Is the triple ""Esomeprazole affects preeclampsia"" supported by the sentence: ""Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.""?",False, +19360632,Esomeprazole affects ulcer disease,3994,Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.,"Is the triple ""Esomeprazole affects ulcer disease"" supported by the sentence: ""Our goal was to verify the effects of esomeprazole on artificial ulcers in a prospective study.""?",False, +18357402,Esomeprazole affects dyspepsia,3995,"Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.","Is the triple ""Esomeprazole affects dyspepsia"" supported by the sentence: ""Here, we investigated the prevalence of GERD symptoms and the effects of the PPI esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.""?",False, +14247859,Esomeprazole affects gastric ulcer,3996,"In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.","Is the triple ""Esomeprazole affects gastric ulcer"" supported by the sentence: ""In the presence of indomethacin, esomeprazole, but not famotidine, enhanced nuclear factor-kB activation in gastric ulcers.""?",False, +12902689,Esomeprazole affects Hemorrhage,3997,The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""The purpose of the present study was to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, +12902688,Esomeprazole affects Hemorrhage,3998,Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.,"Is the triple ""Esomeprazole affects Hemorrhage"" supported by the sentence: ""Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.""?",False, +12527967,Esomeprazole affects gastroesophageal reflux disease,3999,CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.,"Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: The results of this study suggest that the PK parameters of esomeprazole were both dose- and time-dependent in these adolescents with GERD.""?",False, +12015567,Esomeprazole affects gastroesophageal reflux disease,4000,"This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.","Is the triple ""Esomeprazole affects gastroesophageal reflux disease"" supported by the sentence: ""This study examined the effects of esomeprazole on nighttime heartburn, GERD-related sleep disturbances, sleep quality, work productivity, and regular activities.""?",False, +10805094,Esomeprazole disrupts gastroesophageal reflux disease,4001,"The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.","Is the triple ""Esomeprazole disrupts gastroesophageal reflux disease"" supported by the sentence: ""The therapy of BA with associated GERD with Omeprazole in the dose equal to 40 mg per day or Esomeprazole in the dose equal to 40 mg per day contributes to the reliable improvement of both pulmonary and esophageal symptoms, and application of Esomeprazole results in a faster reduction of bronchial obstruction and gastroesophageal reflux.""?",False, +15938697,Esomeprazole prevents gastric ulcer,4002,"Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.","Is the triple ""Esomeprazole prevents gastric ulcer"" supported by the sentence: ""Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.""?",False, +14015294,Esomeprazole prevents gastroesophageal reflux disease,4003,CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.,"Is the triple ""Esomeprazole prevents gastroesophageal reflux disease"" supported by the sentence: ""CONCLUSIONS: Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers.""?",False, +13576722,Esomeprazole prevents peptic ulcer disease,4004,Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.,"Is the triple ""Esomeprazole prevents peptic ulcer disease"" supported by the sentence: ""Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study.""?",False, +12321750,Esomeprazole prevents ulcer disease,4005,"CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.","Is the triple ""Esomeprazole prevents ulcer disease"" supported by the sentence: ""CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.""?",False, +10396538,Roflumilast related to asthma,4006,Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.,"Is the triple ""Roflumilast related to asthma"" supported by the sentence: ""Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.""?",False, +21017284,Roflumilast causes chronic obstructive pulmonary disease,4007,"Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.","Is the triple ""Roflumilast causes chronic obstructive pulmonary disease"" supported by the sentence: ""Collectively, these results suggest that the genomic impact of roflumilast, including its ability to augment LABA-induced gene expression changes, may contribute to its therapeutic activity in COPD.""?",False, +21116198,Roflumilast affects obesity disorder,4008,"Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.","Is the triple ""Roflumilast affects obesity disorder"" supported by the sentence: ""Conclusion: We demonstrate, for the first time in humans, increasing percentage of fat mass loss from roflumilast with increasing age in adults with prediabetes and overweight/obesity.""?",False, +12290110,Roflumilast affects chronic obstructive pulmonary disease,4009,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects chronic obstructive pulmonary disease"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, +12290109,Roflumilast affects asthma,4010,"The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).","Is the triple ""Roflumilast affects asthma"" supported by the sentence: ""The second generation PDE4 inhibitors, cilomilast and roflumilast, have reached clinical trial stage and have some demonstrable beneficial effects in asthma and chronic obstructive pulmonary disease (COPD).""?",False, +22432515,Roflumilast disrupts schizophrenia,4011,"CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.","Is the triple ""Roflumilast disrupts schizophrenia"" supported by the sentence: ""CONCLUSIONS: The results suggest that phosphodiesterase-4 inhibition, with roflumilast, can improve electroencephalogram cognitive markers, which are impaired in schizophrenia, and that phosphodiesterase-4 inhibition acts at an intermediate rather than early or late cognitive processing stage.""?",False, +24502817,Roflumilast prevents obesity disorder,4012,"RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.","Is the triple ""Roflumilast prevents obesity disorder"" supported by the sentence: ""RESULTS: Treatment with the PAN-PDE4 inhibitor Roflumilast reduced high-fat diet-induced obesity in mice, as reflected by reduced body weight and white fat pads, without lowering food consumption or increasing physical activity (unchanged locomotor activity and exercise capacity) suggesting that the weight-loss effect of PDE4 inhibition observed in clinical trials is replicated in the mouse.""?",False, +17763098,Roflumilast prevents diabetic kidney disease,4013,Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.,"Is the triple ""Roflumilast prevents diabetic kidney disease"" supported by the sentence: ""Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.""?",False, +15955656,Roflumilast prevents chronic obstructive pulmonary disease,4014,"Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.","Is the triple ""Roflumilast prevents chronic obstructive pulmonary disease"" supported by the sentence: ""Clinical trials have demonstrated the effect of roflumilast on reducing exacerbation frequency and improving lung function in COPD, while its mode of action may offer the potential to target the inflammatory processes underlying COPD.""?",False, +8310806,Meperidine causes Pain,4015,OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.,"Is the triple ""Meperidine causes Pain"" supported by the sentence: ""OBJECTIVES: Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain.""?",False, +26434893,Meperidine affects Pain,4016,The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.,"Is the triple ""Meperidine affects Pain"" supported by the sentence: ""The observations also indicate that the depolarization of C afferent terminals produced during pain and by stimulation of other cutaneous afferents is potentiated by meperidine.""?",False, +18658715,Meperidine affects Pain,4017,"Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.","Is the triple ""Meperidine affects Pain"" supported by the sentence: ""Effects of Oral Gabapentin, Local Bupivacaine and Intravenous Pethidine on Post Tonsillectomy Pain.""?",False, +8345324,Meperidine prevents Pain,4018,The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.,"Is the triple ""Meperidine prevents Pain"" supported by the sentence: ""The trend for greater pain reduction and patient satisfaction with meperidine needs further investigation.""?",False, +21672389,Ketobemidone affects Pain,4019,"Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.","Is the triple ""Ketobemidone affects Pain"" supported by the sentence: ""Linear regression analysis revealed a significant correlation between ketobemidone serum concentrations and analgesic effect, VAS, for tablet one and for the mixture but not for tablet two, possibly due to the fixed dosing schedule and to the positive effect of hospitalization on the pain.""?",False, +11850764,Travoprost related to ocular hypertension,4020,"CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.","Is the triple ""Travoprost related to ocular hypertension"" supported by the sentence: ""CONCLUSION: This meta-analysis suggests that bimatoprost, travoprost, latanoprost, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.""?",False, +12116829,Travoprost physically interacts with prostanoid FP receptor,4021,"PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.","Is the triple ""Travoprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""PURPOSE: This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice.""?",False, +18294152,Travoprost affects ocular hypertension,4022,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects ocular hypertension"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, +18294151,Travoprost affects glaucoma,4023,Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.,"Is the triple ""Travoprost affects glaucoma"" supported by the sentence: ""Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension.""?",False, +10166996,Travoprost prevents ocular hypertension,4024,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents ocular hypertension"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, +10166995,Travoprost prevents open-angle glaucoma,4025,"CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.","Is the triple ""Travoprost prevents open-angle glaucoma"" supported by the sentence: ""CONCLUSIONS: Latanoprost, bimatoprost, and travoprost were comparable in their ability to reduce IOP in OAG and OH patients.""?",False, +17904574,Tafluprost related to glaucoma,4026,Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.,"Is the triple ""Tafluprost related to glaucoma"" supported by the sentence: ""Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma.""?",False, +15304153,Tafluprost related to ocular hypertension,4027,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to ocular hypertension"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, +15304152,Tafluprost related to open-angle glaucoma,4028,Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost related to open-angle glaucoma"" supported by the sentence: ""Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.""?",False, +14941475,Tafluprost physically interacts with prostanoid FP receptor,4029,Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.,"Is the triple ""Tafluprost physically interacts with prostanoid FP receptor"" supported by the sentence: ""Tafluprost is potent in its affinity for the prostanoid FP receptor and in its intraocular lowering efficacy.""?",False, +14941474,Tafluprost disrupts ocular hypertension,4030,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts ocular hypertension"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, +14941473,Tafluprost disrupts open-angle glaucoma,4031,Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.,"Is the triple ""Tafluprost disrupts open-angle glaucoma"" supported by the sentence: ""Clinical appraisal of tafluprost in the reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.""?",False, +14231277,Ramelteon affects insomnia,4032,"Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.","Is the triple ""Ramelteon affects insomnia"" supported by the sentence: ""Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.""?",False, +21718213,Ramelteon prevents sleep-wake disorder,4033,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Ramelteon prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, +22873470,Melatonin related to acute kidney failure,4034,"Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.","Is the triple ""Melatonin related to acute kidney failure"" supported by the sentence: ""Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway.""?",False, +22002909,Melatonin related to metabolic disease,4035,"Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.","Is the triple ""Melatonin related to metabolic disease"" supported by the sentence: ""Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown.""?",False, +21777340,Melatonin related to Cognitive impairment,4036,"Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.","Is the triple ""Melatonin related to Cognitive impairment"" supported by the sentence: ""Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer.""?",False, +18920431,Melatonin related to burn,4037,"CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.","Is the triple ""Melatonin related to burn"" supported by the sentence: ""CONCLUSION: According to the results of this study, melatonin is efficient in saving the zone of stasis in burns.""?",False, +18846352,Melatonin related to skin disorder,4038,And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.,"Is the triple ""Melatonin related to skin disorder"" supported by the sentence: ""And this study also suggest that melatonin could potentially be utilized as a therapeutic agent in skin disease.""?",False, +18613354,Melatonin related to Neonatal sepsis,4039,Use of melatonin as an adjuvant therapy in neonatal sepsis.,"Is the triple ""Melatonin related to Neonatal sepsis"" supported by the sentence: ""Use of melatonin as an adjuvant therapy in neonatal sepsis.""?",False, +18189253,Melatonin related to necrotizing enterocolitis,4040,"This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.","Is the triple ""Melatonin related to necrotizing enterocolitis"" supported by the sentence: ""This review summarizes what is known about the role of oxidative stress, and potentially beneficial effects of antioxidants, such as melatonin, in necrotizing enterocolitis.""?",False, +17471678,"Melatonin related to dermatitis, atopic",4041,"To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.","Is the triple ""Melatonin related to dermatitis, atopic"" supported by the sentence: ""To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE.""?",False, +17103445,Melatonin related to obstructive sleep apnea syndrome,4042,Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?,"Is the triple ""Melatonin related to obstructive sleep apnea syndrome"" supported by the sentence: ""Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?""?",False, +16423098,Melatonin related to periodontitis,4043,Previous studies reported decreased salivary and serum melatonin levels in periodontitis.,"Is the triple ""Melatonin related to periodontitis"" supported by the sentence: ""Previous studies reported decreased salivary and serum melatonin levels in periodontitis.""?",False, +16022569,Melatonin related to metabolic syndrome X,4044,"In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.","Is the triple ""Melatonin related to metabolic syndrome X"" supported by the sentence: ""In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.""?",False, +15882605,Melatonin related to enuresis,4045,"Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.","Is the triple ""Melatonin related to enuresis"" supported by the sentence: ""Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients.""?",False, +15709123,Melatonin related to fibromyalgia,4046,Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.,"Is the triple ""Melatonin related to fibromyalgia"" supported by the sentence: ""Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.""?",False, +15665905,"Melatonin related to attention deficit hyperactivity disorder, inattentive type",4047,These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.,"Is the triple ""Melatonin related to attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD.""?",False, +14933527,Melatonin related to autism spectrum disorder,4048,"Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.","Is the triple ""Melatonin related to autism spectrum disorder"" supported by the sentence: ""Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.""?",False, +14875890,Melatonin related to pervasive developmental disorder,4049,"Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.","Is the triple ""Melatonin related to pervasive developmental disorder"" supported by the sentence: ""Although controlled studies are limited, there are more data demonstrating the safety and effectiveness of melatonin in ASD than for other sedative/hypnotic drugs.""?",False, +14786958,Melatonin related to gastroesophageal reflux disease,4050,The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.,"Is the triple ""Melatonin related to gastroesophageal reflux disease"" supported by the sentence: ""The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease.""?",False, +13857052,Melatonin related to ulcerative colitis,4051,In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.,"Is the triple ""Melatonin related to ulcerative colitis"" supported by the sentence: ""In this review we summarize the evidence regarding melatonin as a possible therapeutic agent in UC and discuss possible biological mechanisms and directions for future research.""?",False, +13491215,Melatonin related to diabetes mellitus,4052,(v) Melatonin influences diabetes and associated metabolic disturbances.,"Is the triple ""Melatonin related to diabetes mellitus"" supported by the sentence: ""(v) Melatonin influences diabetes and associated metabolic disturbances.""?",False, +13407170,Melatonin related to periodontal disorder,4053,BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.,"Is the triple ""Melatonin related to periodontal disorder"" supported by the sentence: ""BACKGROUND AND OBJECTIVE: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level.""?",False, +13365823,Melatonin related to tooth disorder,4054,"Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.","Is the triple ""Melatonin related to tooth disorder"" supported by the sentence: ""Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation.""?",False, +12843346,Melatonin related to melanoma,4055,"Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.","Is the triple ""Melatonin related to melanoma"" supported by the sentence: ""Lately, the physiological and pathological role of melatonin has become a priority area of investigation, particularly in breast cancer, melanoma, colon cancer, lung cancer and leukemia.""?",False, +12132104,Melatonin related to irritable bowel syndrome,4056,AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).,"Is the triple ""Melatonin related to irritable bowel syndrome"" supported by the sentence: ""AIM: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).""?",False, +11584899,Melatonin related to brain ischemia,4057,"Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.","Is the triple ""Melatonin related to brain ischemia"" supported by the sentence: ""Study quality was generally poor by clinical trial standards, and no evidence was found regarding the efficacy of melatonin in focal cerebral ischaemia in aged, hypertensive or diabetic animals, in species other than rats, or at time windows beyond 2 hr.""?",False, +11533403,Melatonin related to hypertensive disorder,4058,"Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.","Is the triple ""Melatonin related to hypertensive disorder"" supported by the sentence: ""Significant, negative correlation between nighttime Mel concentrations in saliva and both systolic and diastolic blood pressure was shown in patients with moderate and severe hypertension.""?",False, +11319171,Melatonin related to Pain,4059,These results suggest a proalgesic role of endogenous melatonin in tonic pain.,"Is the triple ""Melatonin related to Pain"" supported by the sentence: ""These results suggest a proalgesic role of endogenous melatonin in tonic pain.""?",False, +11137637,Melatonin related to essential hypertension,4060,"OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.","Is the triple ""Melatonin related to essential hypertension"" supported by the sentence: ""OBJECTIVE(S): To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment.""?",False, +10685850,Melatonin related to major depressive disorder,4061,"Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.","Is the triple ""Melatonin related to major depressive disorder"" supported by the sentence: ""Output of melatonin or its main metabolite, 6-sulphatoxy melatonin, provides an index of noradrenergic activity in the pineal gland, which is of interest in major depression and during its treatment with antidepressants.""?",False, +10528037,Melatonin related to multiple sclerosis,4062,"Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.","Is the triple ""Melatonin related to multiple sclerosis"" supported by the sentence: ""Since melatonin secretion is cyclical, undergoing diurnal, weekly, seasonal, and annual variations, it is proposed that the pineal gland may be the ""prime mover"" underlying the spontaneous exacerbations and remissions in MS.""?",False, +10477010,Melatonin related to non-small cell lung carcinoma,4063,"On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.","Is the triple ""Melatonin related to non-small cell lung carcinoma"" supported by the sentence: ""On the basis of previous experimental results suggesting a synergistic action between IL-2 and the pineal neurohormone melatonin (MLT), a study was started to evaluate the clinical efficacy and toxicity of a neuroimmunotherapeutic combination consisting of IL-2 plus MLT as a first line therapy in metastatic NSCLC.""?",False, +10371972,Melatonin related to delirium,4064,"Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.","Is the triple ""Melatonin related to delirium"" supported by the sentence: ""Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.""?",False, +10204563,Melatonin related to depressive disorder,4065,"Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.","Is the triple ""Melatonin related to depressive disorder"" supported by the sentence: ""Numerous studies have reported low melatonin secretion in depression, but other studies have suggested no deficit or an increase.""?",False, +9947492,Melatonin related to myocardial infarction,4066,Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.,"Is the triple ""Melatonin related to myocardial infarction"" supported by the sentence: ""Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.""?",False, +9516882,Melatonin related to Parkinson disease,4067,Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.,"Is the triple ""Melatonin related to Parkinson disease"" supported by the sentence: ""Our results hence provide direct evidence showing that melatonin attenuates MPP+-induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.""?",False, +9086006,Melatonin related to ischemia reperfusion injury,4068,"Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.","Is the triple ""Melatonin related to ischemia reperfusion injury"" supported by the sentence: ""Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury.""?",False, +9074687,Melatonin related to Sepsis,4069,"These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.","Is the triple ""Melatonin related to Sepsis"" supported by the sentence: ""These findings, in accordance with our previous works, suggest that melatonin could be useful in the treatment of sickness behaviour associated with systemic infection diseases or as adjuvant in the anti-anxiety therapy.""?",False, +8867365,Melatonin related to schizophrenia,4070,"CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.","Is the triple ""Melatonin related to schizophrenia"" supported by the sentence: ""CONCLUSIONS: This preliminary study would suggest that schizophrenia may be associated with a diminished secretion of MLT from the pineal gland, and pineal deficiency would be more evident in the chronic disease.""?",False, +8780387,Melatonin related to insomnia,4071,"The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.","Is the triple ""Melatonin related to insomnia"" supported by the sentence: ""The melatonin secretion curve of the old patients with postoperative insomnia (19.961 pg/ml, 20.297 pg/ml, 9.378 pg/ml) or postoperative septic complications (20.695 pg/ml, 16.183 pg/ml, 6.036 pg/ml) was significantly different compared with that of other patients.""?",False, +8686098,Melatonin related to dementia,4072,OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.,"Is the triple ""Melatonin related to dementia"" supported by the sentence: ""OBJECTIVE: The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia.""?",False, +8623112,Melatonin related to migraine disorder,4073,"This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.","Is the triple ""Melatonin related to migraine disorder"" supported by the sentence: ""This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.""?",False, +7795396,Melatonin related to injury,4074,"Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.","Is the triple ""Melatonin related to injury"" supported by the sentence: ""Most important, the data confirms the neuroprotective role of melatonin in Abeta-mediated oxidative injury.""?",False, +7482169,Melatonin related to neoplasm,4075,Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.,"Is the triple ""Melatonin related to neoplasm"" supported by the sentence: ""Melatonin has potentially important influence on the neoplastic growth and direct and indirect oncostatic effect in some forms of neoplasia.""?",False, +7440685,Melatonin related to Fatigue,4076,"Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.","Is the triple ""Melatonin related to Fatigue"" supported by the sentence: ""Increased fatigue of the patients was associated with a lower melatonin level, a higher serotonin level and a lower M/S ratio as compared with patients without fatigue.""?",False, +7185935,Melatonin related to epilepsy,4077,Melatonin in epilepsy: first results of replacement therapy and first clinical results.,"Is the triple ""Melatonin related to epilepsy"" supported by the sentence: ""Melatonin in epilepsy: first results of replacement therapy and first clinical results.""?",False, +7185921,Melatonin related to sleep-wake disorder,4078,Melatonin in circadian sleep disorders in the blind.,"Is the triple ""Melatonin related to sleep-wake disorder"" supported by the sentence: ""Melatonin in circadian sleep disorders in the blind.""?",False, +26987553,Melatonin causes Fatigue,4079,"Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.","Is the triple ""Melatonin causes Fatigue"" supported by the sentence: ""Oral administration of pharmacological doses of melatonin during the day, when melatonin levels are normally minimal, induces fatigue.""?",False, +24500836,Melatonin causes anxiety,4080,"Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.","Is the triple ""Melatonin causes anxiety"" supported by the sentence: ""Kisspeptin, oxytocin and melatonin have been implicated in the etiology of anxiety and neuropsychiatric disorders such as seasonal affective depression.""?",False, +22662368,Melatonin causes dementia,4081,"A chronic melatonin deficiency, with loss of dreams, could cause dementia.","Is the triple ""Melatonin causes dementia"" supported by the sentence: ""A chronic melatonin deficiency, with loss of dreams, could cause dementia.""?",False, +21258564,Melatonin causes multiple sclerosis,4082,"A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.","Is the triple ""Melatonin causes multiple sclerosis"" supported by the sentence: ""A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse.""?",False, +19886996,Melatonin causes Cognitive impairment,4083,"However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.","Is the triple ""Melatonin causes Cognitive impairment"" supported by the sentence: ""However, Melatonin causes less cognitive impairment compared to Passiflora incarnata.""?",False, +19573910,Melatonin causes periodontitis,4084,Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.,"Is the triple ""Melatonin causes periodontitis"" supported by the sentence: ""Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats.""?",False, +17837306,Melatonin causes metabolic disease,4085,"This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.","Is the triple ""Melatonin causes metabolic disease"" supported by the sentence: ""This indicated the functional link between MT2 and T2D risk at the protein level, and it may represent the prevailing pathomechanism for how impaired melatonin signaling causes metabolic disorders and increases the T2D risk.""?",False, +17714427,Melatonin causes myocardial infarction,4086,The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.,"Is the triple ""Melatonin causes myocardial infarction"" supported by the sentence: ""The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.""?",False, +16705153,Melatonin causes Sepsis,4087,Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.,"Is the triple ""Melatonin causes Sepsis"" supported by the sentence: ""Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.""?",False, +15644359,Melatonin causes gastroesophageal reflux disease,4088,Low levels of melatonin lead to gastroesophageal reflux disease (GERD).,"Is the triple ""Melatonin causes gastroesophageal reflux disease"" supported by the sentence: ""Low levels of melatonin lead to gastroesophageal reflux disease (GERD).""?",False, +14831403,Melatonin causes periodontal disorder,4089,"BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.","Is the triple ""Melatonin causes periodontal disorder"" supported by the sentence: ""BACKGROUND: Melatonin, with its antioxidant properties, plays a pertinent role in influencing the pathogenesis of periodontal disease.""?",False, +14171289,Melatonin causes Parkinson disease,4090,"Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.","Is the triple ""Melatonin causes Parkinson disease"" supported by the sentence: ""Four types of neurotoxicity associated with melatonin are identified and the susceptibility of various parts of the RDMP axis to undergo neuropathological change, the tendency for melatonin to induce PD-like behavioural toxicity, and the relationship of this to PD symptomotology are described.""?",False, +14078373,Melatonin causes hypertensive disorder,4091,Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.,"Is the triple ""Melatonin causes hypertensive disorder"" supported by the sentence: ""Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension.""?",False, +13896033,Melatonin causes breast neoplasm,4092,"Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.","Is the triple ""Melatonin causes breast neoplasm"" supported by the sentence: ""Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats.""?",False, +13361926,Melatonin causes ischemia reperfusion injury,4093,The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.,"Is the triple ""Melatonin causes ischemia reperfusion injury"" supported by the sentence: ""The protective effects of Melatonin against cardiac ischemia/reperfusion (I/R)-induced mitochondrial oxidative damage are well documented as an antioxidant agent which prevents and/or modulates the production of reactive oxygen species (ROS) responsible for the reperfusion injury.""?",False, +13039360,Melatonin causes epilepsy,4094,"In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.","Is the triple ""Melatonin causes epilepsy"" supported by the sentence: ""In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity.""?",False, +12762592,Melatonin causes enuresis,4095,"CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.","Is the triple ""Melatonin causes enuresis"" supported by the sentence: ""CONCLUSION: There was some evidence for minor disturbances in the circadian rhythm of melatonin as a cause of enuresis, but the rhythm was not grossly disrupted.""?",False, +12275569,Melatonin causes diabetes mellitus,4096,"Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.","Is the triple ""Melatonin causes diabetes mellitus"" supported by the sentence: ""Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.""?",False, +12071557,Melatonin causes insomnia,4097,"Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.","Is the triple ""Melatonin causes insomnia"" supported by the sentence: ""Melatonin production decreases with advancing age, leading to insomnia and changes in circadian rhythmicity.""?",False, +10432083,Melatonin causes migraine disorder,4098,"The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.","Is the triple ""Melatonin causes migraine disorder"" supported by the sentence: ""The successful treatment of a patient with an acute migraine attack with external magnetic fields, which acutely inhibit melatonin secretion in animals and humans, attests to the importance of the pineal gland in the pathogenesis of migraine headache.""?",False, +10432067,Melatonin causes schizophrenia,4099,"I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.","Is the triple ""Melatonin causes schizophrenia"" supported by the sentence: ""I have suggested that critical changes in melatonin secretion, as mediated by the pineal gland, may exert a crucial role in the onset and pathogenesis of schizophrenia.""?",False, +9114525,Melatonin causes neoplasm,4100,"Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.","Is the triple ""Melatonin causes neoplasm"" supported by the sentence: ""Ten days after induction of tumors, the animals were treated with melatonin or CGP 52608.""?",False, +8785660,Melatonin causes depressive disorder,4101,The melatonin-induced depression was followed by a slow recovery phase.,"Is the triple ""Melatonin causes depressive disorder"" supported by the sentence: ""The melatonin-induced depression was followed by a slow recovery phase.""?",False, +8291971,Melatonin causes injury,4102,"Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.","Is the triple ""Melatonin causes injury"" supported by the sentence: ""Melatonin and methylprednisolone were given intraperitoneally by bolus injections of 100 mg/kg and 30 mg/kg, respectively, immediately after induction of trauma.""?",False, +25620630,Melatonin affects Fatigue,4103,"Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Melatonin increased early evening fatigue and actual sleep, but had no effect on mood: these results are reported in full elsewhere.""?",False, +25259613,Melatonin affects atrial fibrillation,4104,"Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.","Is the triple ""Melatonin affects atrial fibrillation"" supported by the sentence: ""Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling.""?",False, +24144792,Melatonin affects myocardial infarction,4105,"RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.","Is the triple ""Melatonin affects myocardial infarction"" supported by the sentence: ""RESULTS: After the treatment with melatonin, infarct size, the left ventricular end-diastolic diameter (LVEDd), and left ventricular end-systolic diameter (LVEDd) and minimum first derivative of developed pressure (min dP/dt) decreased, while left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and maximum first derivative of developed pressure (max dP/dt) increased in the melatonin-MI (MM) group compared to the placebo-MI (PM) group.""?",False, +24094187,Melatonin affects major depressive disorder,4106,"A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.","Is the triple ""Melatonin affects major depressive disorder"" supported by the sentence: ""A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD.""?",False, +23101890,Melatonin affects periodontitis,4107,The Effect of Melatonin on Periodontitis.,"Is the triple ""Melatonin affects periodontitis"" supported by the sentence: ""The Effect of Melatonin on Periodontitis.""?",False, +22037016,Melatonin affects diabetes mellitus,4108,Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.,"Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.""?",False, +21523229,Melatonin affects anxiety,4109,The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.,"Is the triple ""Melatonin affects anxiety"" supported by the sentence: ""The Effect of Melatonin on Anxiety and Pain of Tourniquet in Intravenous Regional Anesthesia.""?",False, +21046382,Melatonin affects non-small cell lung carcinoma,4110,"Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.","Is the triple ""Melatonin affects non-small cell lung carcinoma"" supported by the sentence: ""Melatonin was proven to possess anticancer actions, whereas its effect on NSCLC and underlying mechanisms remains poorly understood.""?",False, +20888328,Melatonin affects autism spectrum disorder,4111,"In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.","Is the triple ""Melatonin affects autism spectrum disorder"" supported by the sentence: ""In this perspective, we highlight several recent findings that support the hypothesis of pineal gland/melatonin involvement in autism.""?",False, +18858036,Melatonin affects Cognitive impairment,4112,Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.,"Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.""?",False, +18703578,Melatonin affects Marchiafava-Bignami disease,4113,"The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.","Is the triple ""Melatonin affects Marchiafava-Bignami disease"" supported by the sentence: ""The Effect of Melatonin on Bone Loss, Diabetic Control, and Apoptosis in Rats With Diabetes With Ligature-Induced Periodontitis.""?",False, +18605461,Melatonin affects Neonatal sepsis,4114,CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""CONCLUSIONS: Endogenous melatonin concentration is increased in late neonatal sepsis and can potentially be used as a marker for sepsis especially when combined with CRP.""?",False, +18605459,Melatonin affects Neonatal sepsis,4115,Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.,"Is the triple ""Melatonin affects Neonatal sepsis"" supported by the sentence: ""Whether melatonin concentration changes in neonatal sepsis and whether it can be used as a marker of sepsis is unknown.""?",False, +18111864,Melatonin affects Hemorrhage,4116,Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.,"Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines.""?",False, +17774103,Melatonin affects fibromyalgia,4117,"Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).","Is the triple ""Melatonin affects fibromyalgia"" supported by the sentence: ""Melatonin + amitriptyline treated displayed better results than melatonin and amitriptyline alone in terms of FIQ and PPT improvement (P < 0.05, fort both).""?",False, +17471677,"Melatonin affects dermatitis, atopic",4118,Alterations of melatonin secretion in atopic eczema.,"Is the triple ""Melatonin affects dermatitis, atopic"" supported by the sentence: ""Alterations of melatonin secretion in atopic eczema.""?",False, +17402992,Melatonin affects Fatigue,4119,"Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.","Is the triple ""Melatonin affects Fatigue"" supported by the sentence: ""Similarly, some patients may present signs of a ""pinealectomized"" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.""?",False, +17199486,Melatonin affects Sepsis,4120,Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.,"Is the triple ""Melatonin affects Sepsis"" supported by the sentence: ""Our observations show a lack of effect of nNOS on heart bioenergetic impairment during sepsis and further support the beneficial actions of melatonin in sepsis.""?",False, +17103446,Melatonin affects obstructive sleep apnea syndrome,4121,The data on the involvement of melatonin in OSAS are rare.,"Is the triple ""Melatonin affects obstructive sleep apnea syndrome"" supported by the sentence: ""The data on the involvement of melatonin in OSAS are rare.""?",False, +17112614,Melatonin affects ulcerative colitis,4122,Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.,"Is the triple ""Melatonin affects ulcerative colitis"" supported by the sentence: ""Substantial research reveals that melatonin has beneficial effects in ulcerative colitis both experimentally and clinically.""?",False, +16898660,Melatonin affects Cognitive impairment,4123,"Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects.""?",False, +16300651,Melatonin affects depressive disorder,4124,"Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay.""?",False, +16293202,Melatonin affects Hemorrhage,4125,"Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.","Is the triple ""Melatonin affects Hemorrhage"" supported by the sentence: ""Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.""?",False, +16189615,Melatonin affects Cognitive impairment,4126,"The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.","Is the triple ""Melatonin affects Cognitive impairment"" supported by the sentence: ""The p(Abeta3-10)10-MT vaccine induced high titers of anti-Abeta antibodies, which in turn reduced Abeta deposits in the mouse brains and decreased cognitive impairment.""?",False, +15390003,Melatonin affects delirium,4127,Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.,"Is the triple ""Melatonin affects delirium"" supported by the sentence: ""Melatonin is a drug used to sedate patients preoperatively and is hypothesized by recent works to have a curative effect on postoperative delirium.""?",False, +14400565,Melatonin affects burn,4128,Effect of melatonin on burn-induced gastric mucosal injury in rats.,"Is the triple ""Melatonin affects burn"" supported by the sentence: ""Effect of melatonin on burn-induced gastric mucosal injury in rats.""?",False, +14333232,Melatonin affects schizophrenia,4129,"""Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.","Is the triple ""Melatonin affects schizophrenia"" supported by the sentence: """"Down regulation"" of 5-HT2 receptors: possible role of melatonin and significance for negative schizophrenia.""?",False, +13430046,Melatonin affects epilepsy,4130,"Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.","Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Previous studies have shown the participation of melatonin in the control of convulsive crises, suggesting that aMT concentration increases during seizures, and that patients with seizures of diverse origins show an alteration of the aMT rhythm.""?",False, +13158859,Melatonin affects tooth disorder,4131,"RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.","Is the triple ""Melatonin affects tooth disorder"" supported by the sentence: ""RESULTS: Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease.""?",False, +12620684,Melatonin affects melanoma,4132,Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.,"Is the triple ""Melatonin affects melanoma"" supported by the sentence: ""Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo.""?",False, +12473519,Melatonin affects Parkinson disease,4133,Melatonin secretion has been found to be altered in AD and PD.,"Is the triple ""Melatonin affects Parkinson disease"" supported by the sentence: ""Melatonin secretion has been found to be altered in AD and PD.""?",False, +11739216,Melatonin affects sleep-wake disorder,4134,"To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).","Is the triple ""Melatonin affects sleep-wake disorder"" supported by the sentence: ""To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time).""?",False, +11451669,Melatonin affects depressive disorder,4135,"Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Despite the potential influence of immunomodulation on depression, no connection with melatonin representing the retinohypothalamic tract/pineal gland circuits could be detected.""?",False, +10979770,Melatonin affects insomnia,4136,Potential action of melatonin in insomnia.,"Is the triple ""Melatonin affects insomnia"" supported by the sentence: ""Potential action of melatonin in insomnia.""?",False, +10516034,Melatonin affects Pain,4137,"An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.","Is the triple ""Melatonin affects Pain"" supported by the sentence: ""An interaction among melatonin, opioids, and analgesia has been suspected for many years, since during nighttime, when the level of melatonin is high, the mammals are less sensitive to pain.""?",False, +10432086,Melatonin affects multiple sclerosis,4138,Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.,"Is the triple ""Melatonin affects multiple sclerosis"" supported by the sentence: ""Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis.""?",False, +10047665,Melatonin affects hypertensive disorder,4139,Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.,"Is the triple ""Melatonin affects hypertensive disorder"" supported by the sentence: ""Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.""?",False, +9535418,Melatonin affects injury,4140,We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.,"Is the triple ""Melatonin affects injury"" supported by the sentence: ""We studied the effect of the endogenous antioxidant melatonin on excitotoxic injury resulting from N-methyl-D-aspartate (NMDA)-induced damage by developing an organotypic mouse brain slice model.""?",False, +9364224,Melatonin affects Pain,4141,Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.,"Is the triple ""Melatonin affects Pain"" supported by the sentence: ""Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect.""?",False, +9244581,Melatonin affects migraine disorder,4142,"The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.","Is the triple ""Melatonin affects migraine disorder"" supported by the sentence: ""The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.""?",False, +9153135,Melatonin affects diabetes mellitus,4143,"Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.","Is the triple ""Melatonin affects diabetes mellitus"" supported by the sentence: ""Although melatonin has been established as a free radical scavenger and antioxidant, its effects in diabetes have not been thoroughly investigated.""?",False, +9143737,Melatonin affects epilepsy,4144,Melatonin effect on seizures in children with severe neurologic deficit disorders.,"Is the triple ""Melatonin affects epilepsy"" supported by the sentence: ""Melatonin effect on seizures in children with severe neurologic deficit disorders.""?",False, +9114510,Melatonin affects ischemia reperfusion injury,4145,This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.,"Is the triple ""Melatonin affects ischemia reperfusion injury"" supported by the sentence: ""This novel radical-scavenging activity of melatonin may contribute to the previously observed protective effects of melatonin in ischemia-reperfusion injury.""?",False, +8993003,Melatonin affects neoplasm,4146,"However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.","Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.""?",False, +8720758,Melatonin affects breast neoplasm,4147,We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.,"Is the triple ""Melatonin affects breast neoplasm"" supported by the sentence: ""We investigated the effects of altered endogenous nighttime melatonin concentrations on mammary tumor production in an N-nitroso-N-methylurea (NMU)-induced breast cancer model in female Fischer 344 (F344)/N rats.""?",False, +8108047,Melatonin affects depressive disorder,4148,"Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.","Is the triple ""Melatonin affects depressive disorder"" supported by the sentence: ""Injection of the pineal indoles melatonin, 5-methoxytryptophol and 5-methoxytryptamine via the external jugular vein elicited a dose-dependent depression in mean arterial pressure.""?",False, +7564928,Melatonin affects neoplasm,4149,Melatonin also affects tumorigenesis and tumor development.,"Is the triple ""Melatonin affects neoplasm"" supported by the sentence: ""Melatonin also affects tumorigenesis and tumor development.""?",False, +7382212,Melatonin affects brain ischemia,4150,These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.,"Is the triple ""Melatonin affects brain ischemia"" supported by the sentence: ""These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.""?",False, +26765396,Melatonin produces epilepsy,4151,Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.,"Is the triple ""Melatonin produces epilepsy"" supported by the sentence: ""Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.""?",False, +22867260,Melatonin produces diabetes mellitus,4152,"Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.","Is the triple ""Melatonin produces diabetes mellitus"" supported by the sentence: ""Knowing that sleep-wake cycle disruptions impair melatonin production, immune system response and glucose metabolism, and that individuals with diabetes are at higher risk for poor prognosis when infected by SARS-CoV-2 (especially if their blood glucose is out of target), we recommend monitoring and advising these individuals towards strategies to maintain adequate sleep quality and duration as part of their preventive and protective measures during the new pandemic routine.""?",False, +18240585,Melatonin produces ulcerative colitis,4153,METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.,"Is the triple ""Melatonin produces ulcerative colitis"" supported by the sentence: ""METHOD: Gene expression data from normal intestine and pancreas and inflamed colon tissue due to ulcerative colitis were analyzed for expression of enzymes relevant for serotonin and melatonin production and their receptors.""?",False, +17207380,Melatonin produces autism spectrum disorder,4154,"Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.","Is the triple ""Melatonin produces autism spectrum disorder"" supported by the sentence: ""Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism.""?",False, +17051558,Melatonin produces depressive disorder,4155,These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.,"Is the triple ""Melatonin produces depressive disorder"" supported by the sentence: ""These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.""?",False, +16192357,Melatonin produces sleep-wake disorder,4156,"The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.","Is the triple ""Melatonin produces sleep-wake disorder"" supported by the sentence: ""The pathophysiology of posttraumatic circadian sleep disorders remains elusive; however, there is some evidence that reduced evening melatonin production due to traumatic brain damage may cause disruption of circadian regulation of sleep and wakefulness.""?",False, +13817260,Melatonin produces Parkinson disease,4157,"Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.","Is the triple ""Melatonin produces Parkinson disease"" supported by the sentence: ""Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.""?",False, +11388402,Melatonin produces neoplasm,4158,"The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.","Is the triple ""Melatonin produces neoplasm"" supported by the sentence: ""The results demonstrated that during tumour development there is a modification of pineal melatonin production daily profile, possibly contributing to cachexia, associated to changes in pineal gland response to noradrenaline stimulation.""?",False, +9153153,Melatonin produces hypertensive disorder,4159,"Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.","Is the triple ""Melatonin produces hypertensive disorder"" supported by the sentence: ""Transgenic TGR(mREN2)27 rats (TGR), carrying an additional mouse renin gene, are characterized by severe hypertension, an inverse circadian blood pressure profile, a blunted response to photic entrainment signals, and an increased nocturnal production of the pineal hormone melatonin.""?",False, +8191029,Melatonin produces breast neoplasm,4160,"The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.","Is the triple ""Melatonin produces breast neoplasm"" supported by the sentence: ""The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis.""?",False, +24623673,Melatonin disrupts atrial fibrillation,4161,Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).,"Is the triple ""Melatonin disrupts atrial fibrillation"" supported by the sentence: ""Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).""?",False, +24220852,Melatonin disrupts metabolic disease,4162,"Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.","Is the triple ""Melatonin disrupts metabolic disease"" supported by the sentence: ""Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression.""?",False, +22817547,Melatonin disrupts anxiety,4163,"Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.","Is the triple ""Melatonin disrupts anxiety"" supported by the sentence: ""Melatonin versus placebo Melatonin probably results in a reduction in preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) compared to placebo (mean difference (MD) -11.69, 95% confidence interval (CI) -13.80 to -9.59; 18 studies, 1264 participants; moderate-certainty evidence), based on a meta-analysis of 18 studies.""?",False, +20966258,Melatonin disrupts Cognitive impairment,4164,"Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.","Is the triple ""Melatonin disrupts Cognitive impairment"" supported by the sentence: ""Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.""?",False, +20623050,"Melatonin disrupts attention deficit hyperactivity disorder, inattentive type",4165,Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.,"Is the triple ""Melatonin disrupts attention deficit hyperactivity disorder, inattentive type"" supported by the sentence: ""Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model.""?",False, +19958338,Melatonin disrupts multiple sclerosis,4166,Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.,"Is the triple ""Melatonin disrupts multiple sclerosis"" supported by the sentence: ""Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis.""?",False, +18007482,Melatonin disrupts Sepsis,4167,"Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.","Is the triple ""Melatonin disrupts Sepsis"" supported by the sentence: ""Furthermore, sepsis reduced the expression of the transcription factor CREBH which was entirely suppressed by melatonin.""?",False, +18002672,Melatonin disrupts Pain,4168,STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.,"Is the triple ""Melatonin disrupts Pain"" supported by the sentence: ""STUDY OBJECTIVE: To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy.""?",False, +16753621,Melatonin disrupts sleep-wake disorder,4169,"Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.","Is the triple ""Melatonin disrupts sleep-wake disorder"" supported by the sentence: ""Compared to baseline, melatonin and clonazepam reduced sleep disorders in patients: PDSS scores from 89.9+/-8.9 to 129.5+/-9.4 (p=0.0001) and from 91.0+/-8.7 to 110.1+/-12.4 scores (p=0.03), respectively.""?",False, +14914180,Melatonin disrupts melanoma,4170,"Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.","Is the triple ""Melatonin disrupts melanoma"" supported by the sentence: ""Finally, the reported associations between hormonal factors and melanoma are consistent with melatonin inhibition increasing the risk of melanoma by increasing circulating oestrogen levels.""?",False, +14617999,"Melatonin disrupts dermatitis, atopic",4171,"Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.","Is the triple ""Melatonin disrupts dermatitis, atopic"" supported by the sentence: ""Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.""?",False, +13855513,Melatonin disrupts Hemorrhage,4172,"Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.","Is the triple ""Melatonin disrupts Hemorrhage"" supported by the sentence: ""Our results indicate that the melatonin-mediated reductions in ischemic brain damage and reperfusion-induced hemorrhage are partly attributed to its ability to reduce postischemic MMP-9 activation and increased expression, and further support the fact that melatonin is a suitable as an add-on to thrombolytic therapy for ischemic stroke patients.""?",False, +10721769,Melatonin disrupts depressive disorder,4173,Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.,"Is the triple ""Melatonin disrupts depressive disorder"" supported by the sentence: ""Further investigations will be necessary to establish whether melatonin reduction in depression and other disorders leads secondarily to dysregulation of other circadian rhythms.""?",False, +10333555,Melatonin disrupts injury,4174,"Moreover, melatonin diminished iron-induced oxidative injury.","Is the triple ""Melatonin disrupts injury"" supported by the sentence: ""Moreover, melatonin diminished iron-induced oxidative injury.""?",False, +10294227,Melatonin disrupts breast neoplasm,4175,"During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.","Is the triple ""Melatonin disrupts breast neoplasm"" supported by the sentence: ""During the promotion phase, there was a dose-dependent inhibitory effect (up to 65% inhibition) of the daily administration of Melatonin, on mammary tumors occurrence.""?",False, +10070181,Melatonin disrupts brain ischemia,4176,"Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.","Is the triple ""Melatonin disrupts brain ischemia"" supported by the sentence: ""Melatonin in vivo directly constricts cerebral arterioles in rats and decreases the lower limit of cerebral blood flow autoregulation, suggesting that melatonin may diminish the risk of hypoperfusion-induced cerebral ischemia.""?",False, +10008170,Melatonin disrupts Marchiafava-Bignami disease,4177,"Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.","Is the triple ""Melatonin disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Additionally, melatonin may impair development of osteopenia associated with senescence by improving non-rapid eye movement sleep and restoring GH secretion.""?",False, +8932328,Melatonin disrupts epilepsy,4178,"Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.","Is the triple ""Melatonin disrupts epilepsy"" supported by the sentence: ""Because MT was considered as an antistressor and a natural downregulator of epileptiform activity, we postulate that the elevation in MT level during seizures may be one endogenous mechanism that counteracts convulsions and seizure-induced stress.""?",False, +7916082,Melatonin disrupts ischemia reperfusion injury,4179,"Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.","Is the triple ""Melatonin disrupts ischemia reperfusion injury"" supported by the sentence: ""Melatonin (applied at 3 mg/kg, 5 min prior to reperfusion, followed by an infusion of 3 mg/kg per hr), significantly reduced ischemia reperfusion injury in the bowel as evaluated by histological examination.""?",False, +7545973,Melatonin disrupts neoplasm,4180,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin disrupts neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, +24902716,Melatonin prevents stomatitis,4181,"MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).","Is the triple ""Melatonin prevents stomatitis"" supported by the sentence: ""MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35).""?",False, +24687342,Melatonin prevents essential hypertension,4182,The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.,"Is the triple ""Melatonin prevents essential hypertension"" supported by the sentence: ""The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated.""?",False, +24623674,Melatonin prevents atrial fibrillation,4183,"Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.","Is the triple ""Melatonin prevents atrial fibrillation"" supported by the sentence: ""Overall, our study demonstrates that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression, and these effects are partially dependent on melatonin receptor activation.""?",False, +24368351,Melatonin prevents acute kidney failure,4184,"Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.","Is the triple ""Melatonin prevents acute kidney failure"" supported by the sentence: ""Our findings suggest that melatonin prevents cisplatin-induced acute kidney injury in mice, possibly by upregulating the expression of PPARalpha, resulting in enhanced FAO and anti-apoptotic properties.""?",False, +23824121,Melatonin prevents dementia,4185,"While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.","Is the triple ""Melatonin prevents dementia"" supported by the sentence: ""While there is some evidence to suggest that melatonin is able to reduce post-TBI cognitive decline as measured by subject performance on memory tasks, there is a lack of longitudinal data on whether melatonin decreases the risk of developing dementia after TBI.""?",False, +23122960,Melatonin prevents Cognitive impairment,4186,Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.,"Is the triple ""Melatonin prevents Cognitive impairment"" supported by the sentence: ""Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.""?",False, +22817548,Melatonin prevents anxiety,4187,"Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).","Is the triple ""Melatonin prevents anxiety"" supported by the sentence: ""Melatonin may reduce immediate postoperative anxiety measured on a 0 to 100 mm VAS compared to placebo (MD -5.04, 95% CI -9.52 to -0.55; 7 studies, 524 participants; low-certainty evidence), and may reduce delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) (MD -5.31, 95% CI -8.78 to -1.84; 2 studies; 73 participants; low-certainty evidence).""?",False, +21718214,Melatonin prevents sleep-wake disorder,4188,"In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.","Is the triple ""Melatonin prevents sleep-wake disorder"" supported by the sentence: ""In selected articles, the leading topics analysed were the role of melatonin and ramelteon in the prevention of delirium and sleep disorders.""?",False, +20260777,Melatonin prevents Pain,4189,"In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).","Is the triple ""Melatonin prevents Pain"" supported by the sentence: ""In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD).""?",False, +19640170,Melatonin prevents aortic aneurysm,4190,This study examined whether melatonin has protective or therapeutic effects against AAAs.,"Is the triple ""Melatonin prevents aortic aneurysm"" supported by the sentence: ""This study examined whether melatonin has protective or therapeutic effects against AAAs.""?",False, +18396849,Melatonin prevents Sepsis,4191,Previous studies have suggested that melatonin is protective during sepsis.,"Is the triple ""Melatonin prevents Sepsis"" supported by the sentence: ""Previous studies have suggested that melatonin is protective during sepsis.""?",False, +18141997,Melatonin prevents metabolic disease,4192,Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.,"Is the triple ""Melatonin prevents metabolic disease"" supported by the sentence: ""Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.""?",False, +16995162,Melatonin prevents metabolic syndrome X,4193,Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.,"Is the triple ""Melatonin prevents metabolic syndrome X"" supported by the sentence: ""Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens.""?",False, +16549748,Melatonin prevents burn,4194,Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.,"Is the triple ""Melatonin prevents burn"" supported by the sentence: ""Melatonin protects against burn-induced hepatic injury as to a certain extent this effect may result from the suppression of NF-kappaB-mediated inflammatory response.""?",False, +16245777,Melatonin prevents schizophrenia,4195,"The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.","Is the triple ""Melatonin prevents schizophrenia"" supported by the sentence: ""The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management.""?",False, +16232642,Melatonin prevents Marchiafava-Bignami disease,4196,"This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.","Is the triple ""Melatonin prevents Marchiafava-Bignami disease"" supported by the sentence: ""This brief editorial comment sheds some ""light"" into a novel use for melatonin in preventing facial bone loss.""?",False, +15150085,Melatonin prevents depressive disorder,4197,"It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.","Is the triple ""Melatonin prevents depressive disorder"" supported by the sentence: ""It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD.""?",False, +14373042,Melatonin prevents Parkinson disease,4198,"We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.","Is the triple ""Melatonin prevents Parkinson disease"" supported by the sentence: ""We also evaluated the role of melatonin (aMT) and its brain metabolite, N(1)-acetyl-5-methoxykynuramine (AMK), in preventing i-mtNOS induction and mitochondrial failure in this model of PD.""?",False, +11616466,Melatonin prevents autism spectrum disorder,4199,CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.,"Is the triple ""Melatonin prevents autism spectrum disorder"" supported by the sentence: ""CONCLUSIONS: These findings indicate clearly that nocturnal production of melatonin is reduced in autism.""?",False, +11366467,Melatonin prevents migraine disorder,4200,"Melatonin, 3 mg, is effective for migraine prevention.","Is the triple ""Melatonin prevents migraine disorder"" supported by the sentence: ""Melatonin, 3 mg, is effective for migraine prevention.""?",False, +11108260,Melatonin prevents hypertensive disorder,4201,We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.,"Is the triple ""Melatonin prevents hypertensive disorder"" supported by the sentence: ""We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.""?",False, +11061121,Melatonin prevents insomnia,4202,Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.,"Is the triple ""Melatonin prevents insomnia"" supported by the sentence: ""Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.""?",False, +10234923,Melatonin prevents breast neoplasm,4203,Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.,"Is the triple ""Melatonin prevents breast neoplasm"" supported by the sentence: ""Melatonin also reduces the incidence of spontaneous mammary tumors in different kinds of transgenic mice (c-neu and N-ras) and mice from strains with a high tumoral incidence.""?",False, +10127047,Melatonin prevents myocardial infarction,4204,Protective effect of melatonin on myocardial infarction.,"Is the triple ""Melatonin prevents myocardial infarction"" supported by the sentence: ""Protective effect of melatonin on myocardial infarction.""?",False, +9561452,Melatonin prevents diabetes mellitus,4205,Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.,"Is the triple ""Melatonin prevents diabetes mellitus"" supported by the sentence: ""Supplementation with antioxidant molecules such as melatonin may serve as a protection against diabetes.""?",False, +9346845,Melatonin prevents delirium,4206,Two cases are presented where melatonin was used to treat and prevent postoperative delirium.,"Is the triple ""Melatonin prevents delirium"" supported by the sentence: ""Two cases are presented where melatonin was used to treat and prevent postoperative delirium.""?",False, +9336280,Melatonin prevents brain ischemia,4207,"Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.","Is the triple ""Melatonin prevents brain ischemia"" supported by the sentence: ""Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion.""?",False, +8678642,Melatonin prevents epilepsy,4208,"The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.","Is the triple ""Melatonin prevents epilepsy"" supported by the sentence: ""The AIP patients with epileptic seizures had a significantly lower urinary excretion of melatonin, compared with their AIP relatives without epilepsy, which may indicate that melatonin has a protective effect on seizures.""?",False, +8166782,Melatonin prevents ischemia reperfusion injury,4209,"In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.","Is the triple ""Melatonin prevents ischemia reperfusion injury"" supported by the sentence: ""In conclusion, both melatonin and its structural analog, 5-MCA-NAT, appear to confer protection against ischemia-reperfusion injury in the isolated rat heart.""?",False, +7622774,Melatonin prevents injury,4210,CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.,"Is the triple ""Melatonin prevents injury"" supported by the sentence: ""CONCLUSION: Melatonin decreased the injury and production of .OH after hypoxia.""?",False, +7545974,Melatonin prevents neoplasm,4211,"Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.","Is the triple ""Melatonin prevents neoplasm"" supported by the sentence: ""Also, MEL counteracts tumors because of its influence on immune responses via the metabolic zinc pool, which, is reduced in tumors and stress.""?",False, +19276524,Melatonin exacerbates diabetes mellitus,4212,"However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.","Is the triple ""Melatonin exacerbates diabetes mellitus"" supported by the sentence: ""However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes.""?",False, +7980097,Melatonin exacerbates brain ischemia,4213,"Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.","Is the triple ""Melatonin exacerbates brain ischemia"" supported by the sentence: ""Pinealectomy, which eliminates the nighttime rise in circulating and tissue melatonin levels, worsens both reactive oxygen species-mediated tissue damage and brain damage after focal cerebral ischemia and excitotoxic seizures.""?",False, +27283551,Melatonin predisposes hypertensive disorder,4214,"Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.","Is the triple ""Melatonin predisposes hypertensive disorder"" supported by the sentence: ""Melatonin may exert protective effects on the cardiovascular system, by reducing the risk of atherosclerosis and hypertension, and may influence immune responses.""?",False, +23266236,Melatonin predisposes epilepsy,4215,"CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.","Is the triple ""Melatonin predisposes epilepsy"" supported by the sentence: ""CONCLUSION: We concluded that, in addition to causing obesity, abnormalities in the MC4R gene may contribute to the development of sleep disorders and epilepsy, and that melatonin can be used as an adjuvant therapy to alleviate these symptoms.""?",False, +21026194,Melatonin predisposes migraine disorder,4216,"CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.","Is the triple ""Melatonin predisposes migraine disorder"" supported by the sentence: ""CONCLUSION: While urinary melatonin metabolites do not predict migraine attacks in children and adolescents overall, they may be predictive in those who experience premonitory phase symptoms as part of their migraine attacks.""?",False, +20835242,Melatonin predisposes metabolic syndrome X,4217,"Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.","Is the triple ""Melatonin predisposes metabolic syndrome X"" supported by the sentence: ""Thus, the low level of endogenic melatonin and disturbances of circadian dynamics of its synthesis with the decrease in the night and increase in the evening portions are the risk factors for MS and CCI.""?",False, +20419573,Melatonin predisposes major depressive disorder,4218,Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.,"Is the triple ""Melatonin predisposes major depressive disorder"" supported by the sentence: ""Low nocturnal melatonin is proposed to be a trait marker for major depressive disorder and depressive states with abnormalities in the hypothalamic--pituitary--adrenal (HPA) axis.""?",False, +19382519,Melatonin predisposes periodontal disorder,4219,"With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.","Is the triple ""Melatonin predisposes periodontal disorder"" supported by the sentence: ""With increased severity of periodontal disease, the level of salivary melatonin also increased suggesting that salivary melatonin may act as a diagnostic biomarker for periodontal diseases.""?",False, +18749948,Melatonin predisposes autism spectrum disorder,4220,"This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.","Is the triple ""Melatonin predisposes autism spectrum disorder"" supported by the sentence: ""This study proves the possibility of using oxytocin and melatonin in the diagnosis, and as markers of autism severity.""?",False, +18605458,Melatonin predisposes Neonatal sepsis,4221,OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.,"Is the triple ""Melatonin predisposes Neonatal sepsis"" supported by the sentence: ""OBJECTIVE: The objective of this study is to evaluate melatonin concentration in the serum as a marker for neonatal sepsis and compare it to standard markers.""?",False, +18359560,Melatonin predisposes depressive disorder,4222,Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).,"Is the triple ""Melatonin predisposes depressive disorder"" supported by the sentence: ""Multiple regression analysis showed that reduced melatonin level deteriorates quality of nocturnal sleep and increases the risk of depression (R = 0.4. coefficient beta = -0.413 (p<0.04) and F = 4.5).""?",False, +16852096,Melatonin predisposes diabetes mellitus,4223,Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.,"Is the triple ""Melatonin predisposes diabetes mellitus"" supported by the sentence: ""Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.""?",False, +15094135,Melatonin predisposes injury,4224,"The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.","Is the triple ""Melatonin predisposes injury"" supported by the sentence: ""The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid profile, inflammatory markers, electrocardiographic and histopathological changes.""?",False, +14875892,Melatonin predisposes pervasive developmental disorder,4225,A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.,"Is the triple ""Melatonin predisposes pervasive developmental disorder"" supported by the sentence: ""A recent study using a combination of genetic and functional experimental techniques reported evidence that low melatonin concentration caused by a primary deficit in acetylserotonin methyltransferase activity is a risk factor for ASD.""?",False, +11794031,Melatonin predisposes neoplasm,4226,"Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.","Is the triple ""Melatonin predisposes neoplasm"" supported by the sentence: ""Future studies should properly account for the effect of such variables, when addressing the hypothesis of disturbances in melatonin secretion as a plausible explanation for the reported excess risk of several tumoral diseases associated with low level ELF-EMF exposure.""?",False, +11643546,Melatonin predisposes dementia,4227,Melatonin relieves the neural oxidative burden that contributes to dementias.,"Is the triple ""Melatonin predisposes dementia"" supported by the sentence: ""Melatonin relieves the neural oxidative burden that contributes to dementias.""?",False, +10915746,Melatonin predisposes sleep-wake disorder,4228,"CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.","Is the triple ""Melatonin predisposes sleep-wake disorder"" supported by the sentence: ""CONCLUSIONS: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.""?",False, +10114913,Melatonin predisposes myocardial infarction,4229,These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.,"Is the triple ""Melatonin predisposes myocardial infarction"" supported by the sentence: ""These findings have implications for the elderly since in the aged endogenous levels of melatonin are naturally reduced thereby possibly predisposing them to more severe cardiac damage during a heart attack.""?",False, +12950718,RETEPLASE related to thrombotic disease,4230,Spotlight on reteplase in thrombotic occlusive disorders.,"Is the triple ""RETEPLASE related to thrombotic disease"" supported by the sentence: ""Spotlight on reteplase in thrombotic occlusive disorders.""?",False, +7082056,RETEPLASE related to stroke disorder,4231,"Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.","Is the triple ""RETEPLASE related to stroke disorder"" supported by the sentence: ""Double bolus administration of tPA to patients with acute myocardial infarction is associated with total patency, TIMI 3 patency, mortality, stroke and intracranial haemorrhage rates similar to those associated with either accelerated infusion of tPA or bolus reteplase.""?",False, +12026281,UROKINASE related to stroke disorder,4232,Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.,"Is the triple ""UROKINASE related to stroke disorder"" supported by the sentence: ""Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases.""?",False, +11808316,UROKINASE related to empyema,4233,"Intrapleural urokinase is an effective treatment, including in empyemas without loculation.","Is the triple ""UROKINASE related to empyema"" supported by the sentence: ""Intrapleural urokinase is an effective treatment, including in empyemas without loculation.""?",False, +9909017,UROKINASE related to pleural empyema,4234,Use of urokinase in childhood pleural empyema.,"Is the triple ""UROKINASE related to pleural empyema"" supported by the sentence: ""Use of urokinase in childhood pleural empyema.""?",False, +9695495,UROKINASE related to thrombotic disease,4235,Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.,"Is the triple ""UROKINASE related to thrombotic disease"" supported by the sentence: ""Alteplase versus urokinase in restoring blood flow in hemodialysis-catheter thrombosis.""?",False, +7757067,UROKINASE related to pulmonary embolism,4236,CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.,"Is the triple ""UROKINASE related to pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: Intrapulmonary artery infusion of urokinase in extensive pulmonary embolism is a safe and efficient treatment in patients with and without contraindication to the use of systemic thrombolytic therapy.""?",False, +20949144,UROKINASE causes thrombotic disease,4237,"After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.","Is the triple ""UROKINASE causes thrombotic disease"" supported by the sentence: ""After induction of thrombosis, either tissue-type plasminogen activator (t-PA) or urokinase (UK) was infused just proximal to the thrombus (4000 U/min) until complete thrombolysis was achieved.""?",False, +7392657,UROKINASE causes pulmonary embolism,4238,"Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.","Is the triple ""UROKINASE causes pulmonary embolism"" supported by the sentence: ""Streptokinase, urokinase, tissue plasminogen activator and similar drugs can all cause lysis of venous thrombi and pulmonary emboli, but there is small evidence that accelerated lysis achieves a significantly better clinical outcome, on average, in the shorter or longer term, than heparin alone.""?",False, +26135964,UROKINASE affects pulmonary embolism,4239,A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.,"Is the triple ""UROKINASE affects pulmonary embolism"" supported by the sentence: ""A controlled clinical trial on the effect of heparin infusion and two regimens of urokinase in acute pulmonary embolism.""?",False, +25781305,UROKINASE affects thrombotic disease,4240,"Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.","Is the triple ""UROKINASE affects thrombotic disease"" supported by the sentence: ""Using this method and plasminogen- (125)I as a tracer, studies were first made of the effects of heparin and epsilon-aminocaproic acid in dogs on plasmin- (125)I generation in responese to a single injection of urokinase and to venous injury; second, of the effects of venous occlusion and thrombosis on plasmin- (125)I generation; and third, in vitro studies of plasminogen- (125)I affinity to fibrin and its activation in blood clots.""?",False, +26885635,UROKINASE disrupts thrombotic disease,4241,"In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.","Is the triple ""UROKINASE disrupts thrombotic disease"" supported by the sentence: ""In the thrombosis model in rat abdominal aorta, both urokinase and streptokinase (40,000 IU.kg-1) slightly inhibited electrically stimulated thrombosis.""?",False, +11607211,UROKINASE prevents thrombotic disease,4242,"To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.","Is the triple ""UROKINASE prevents thrombotic disease"" supported by the sentence: ""To obviate the risks associated with systemic anticoagulation, we have investigated the use of topically applied urokinase for its binding capacity to arterial subendothelium and for its ability to prevent subsequent thrombosis.""?",False, +8505599,UROKINASE prevents pulmonary embolism,4243,"CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.","Is the triple ""UROKINASE prevents pulmonary embolism"" supported by the sentence: ""CONCLUSIONS: All PE were asymptomatic during PSPMT, but treatment with UK reduced the rate of PE and tended to result in smaller defects in lung scan results.""?",False, +26334889,UROKINASE predisposes pulmonary embolism,4244,"Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.","Is the triple ""UROKINASE predisposes pulmonary embolism"" supported by the sentence: ""Clinical studies show that although streptokinase and urokinase promote more rapid resolution of PE and DVT (as determined by perfusion lung scans, angiography, and venography), superiority over conventional treatment has not been established.""?",False, +13797160,UROKINASE predisposes thrombotic disease,4245,"Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.","Is the triple ""UROKINASE predisposes thrombotic disease"" supported by the sentence: ""Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.""?",False, +13590349,Buspirone causes depressive disorder,4246,"Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.","Is the triple ""Buspirone causes depressive disorder"" supported by the sentence: ""Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 micrograms/kg produced a sustained enhancement of responding while higher doses (100-300 micrograms/kg) produced a relatively short-lasting depression.""?",False, +7712722,Buspirone affects depressive disorder,4247,"The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.","Is the triple ""Buspirone affects depressive disorder"" supported by the sentence: ""The present observations are of significance to experimental and clinical studies of the influence of buspirone upon depressive states, alone and in association with antidepressant agents.""?",False, +7425584,Buspirone affects physiological sexual disorder,4248,It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.,"Is the triple ""Buspirone affects physiological sexual disorder"" supported by the sentence: ""It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.""?",False, +19950288,Buspirone disrupts schizophrenia,4249,Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.,"Is the triple ""Buspirone disrupts schizophrenia"" supported by the sentence: ""Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.""?",False, +10992881,Buspirone disrupts anxiety,4250,"CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.","Is the triple ""Buspirone disrupts anxiety"" supported by the sentence: ""CONCLUSIONS: Buspirone abolishes stress-induced anxiety, but has no anxiolytic effects in controls.""?",False, +19904227,Iodine related to thyroid tumor,4251,Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.,"Is the triple ""Iodine related to thyroid tumor"" supported by the sentence: ""Iodine-124 (124I) assessing the iodine metabolism may be used for dosimetry and diagnostic purposes in thyroid tumors.""?",False, +10048388,Iodine related to breast neoplasm,4252,"Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.","Is the triple ""Iodine related to breast neoplasm"" supported by the sentence: ""Unlike thyroid, perchlorate and thiocyanate do not inhibit iodine transport in breast tumors.""?",False, +10651106,Iodine causes thyroid tumor,4253,Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.,"Is the triple ""Iodine causes thyroid tumor"" supported by the sentence: ""Electron microscopy of the thyroid tumors induced by iodine deficiency in rats.""?",False, +10745802,Iodine affects thyroid tumor,4254,Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.,"Is the triple ""Iodine affects thyroid tumor"" supported by the sentence: ""Effect of iodine on thyroid tumors induced in the rat by a low-iodine diet.""?",False, +24773674,Iodine prevents thyroid tumor,4255,These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.,"Is the triple ""Iodine prevents thyroid tumor"" supported by the sentence: ""These studies suggest that a major role of iodine is to prevent the formation of thyroid tumors in humans and animals.""?",False, +27167996,Iodine predisposes thyroid tumor,4256,Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.,"Is the triple ""Iodine predisposes thyroid tumor"" supported by the sentence: ""Iodine deficiency may increase the risk for thyroid neoplasms in humans and experimental animals.""?",False, +7362584,Acetaminophen subclass of Acetaminophen sulfate,4257,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen sulfate"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, +7362582,Acetaminophen subclass of Acetaminophen glucuronide,4258,"The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.","Is the triple ""Acetaminophen subclass of Acetaminophen glucuronide"" supported by the sentence: ""The urinary metabolites after a therapeutic dose of paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy-paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide, 3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and paracetamol 3-mercapturate.""?",False, +26133523,Acetaminophen related to neoplasm,4259,"None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.","Is the triple ""Acetaminophen related to neoplasm"" supported by the sentence: ""None of these chemicals, p-hydroxyacetanilide, sodium sulfate, or L-methionine, significantly affected the incidence of forestomach papillomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide, although tumor incidences in all groups were low. p-Hydroxyacetanilide and sodium sulfate had no significant effect on the high incidence of stomach tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide or bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.""?",False, +25084939,Acetaminophen related to Acetimidoquinone,4260,"Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.","Is the triple ""Acetaminophen related to Acetimidoquinone"" supported by the sentence: ""Basal fatty acids and adrenergic stimulated OCR of mitochondria and 3T3-L1 adipocytes were assessed with acetaminophen and compared to NAPQI, etomoxir, and various mitochondrial stress compounds.""?",False, +24055705,Acetaminophen related to osteoarthritis,4261,"As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.","Is the triple ""Acetaminophen related to osteoarthritis"" supported by the sentence: ""As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed.""?",False, +20371329,Acetaminophen related to digestive system disorder,4262,Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.,"Is the triple ""Acetaminophen related to digestive system disorder"" supported by the sentence: ""Monitoring of trace amount of acetaminophen and estrogen in drinking water is of great importance because of their potential links to gastrointestinal diseases and breast and prostate cancers.""?",False, +19637295,Acetaminophen related to Renal Colic,4263,"METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.","Is the triple ""Acetaminophen related to Renal Colic"" supported by the sentence: ""METHODS AND ANALYSIS: This is the protocol for a systematic review, comparing efficacy of NSAIDs, opioids and paracetamol in renal colic studied under randomised controlled trial (RCT) design.""?",False, +16009572,Acetaminophen related to rheumatoid arthritis,4264,"The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).","Is the triple ""Acetaminophen related to rheumatoid arthritis"" supported by the sentence: ""The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.).""?",False, +12233599,Acetaminophen related to Acetaminophen glucuronide,4265,The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.,"Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The objective was to compare the plasma concentrations of free paracetamol and the major metabolites paracetamol-sulphate and paracetamol-glucuronide for a 6 hr period after each test drug.""?",False, +12541409,Acetaminophen related to Acetaminophen glucuronide,4266,"The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).","Is the triple ""Acetaminophen related to Acetaminophen glucuronide"" supported by the sentence: ""The formation clearance (mean +/- SD; N = 4/group) of acetaminophen glucuronide (AG) was greater from administered compared to generated acetaminophen during normoxia (0.47 +/- 0.15 vs. 0.22 +/- 0.06 ml/min, p less than 0.05), and was decreased 2- to 3-fold during hypoxia (0.14 +/- 0.08 vs. 0.11 +/- 0.07 ml/min).""?",False, +15777318,Acetaminophen coexists with Acetimidoquinone,4267,"In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.","Is the triple ""Acetaminophen coexists with Acetimidoquinone"" supported by the sentence: ""In view of the fact that paracetamol caused a massive reduction in non-protein-SH and ascorbic acid, we realize that the protective effect of ebselen on delta-ALA-D activity is mediated by its thiol peroxidase-like activity or by a direct interaction with NAPQI and other reactive species formed during paracetamol metabolism.""?",False, +18513016,Acetaminophen derives from Acetimidoquinone,4268,"Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.","Is the triple ""Acetaminophen derives from Acetimidoquinone"" supported by the sentence: ""Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.""?",False, +16596646,Acetaminophen derives from Acetaminophen glucuronide,4269,Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.,"Is the triple ""Acetaminophen derives from Acetaminophen glucuronide"" supported by the sentence: ""Decreased biliary recovery of AG occurred despite a Pb-induced increase in the fraction of the acetaminophen dose converted to AG.""?",False, +7891577,Acetaminophen physically interacts with Acetimidoquinone,4270,"Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""Acetaminophen, or N-acetyl-p-aminophenol (APAP), is metabolized to N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 enzymes in the liver.""?",False, +11100770,Acetaminophen physically interacts with Acetimidoquinone,4271,"All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).","Is the triple ""Acetaminophen physically interacts with Acetimidoquinone"" supported by the sentence: ""All of the harmful effects of acetaminophen have been attributed to the production of its toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI).""?",False, +8441876,Acetaminophen physically interacts with Acetaminophen glucuronide,4272,"Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.","Is the triple ""Acetaminophen physically interacts with Acetaminophen glucuronide"" supported by the sentence: ""Acetaminophen and acetaminophen glucuronide had no effect on the hepatic disposition of GG, suggesting relatively low affinities of acetaminophen conjugates for hepatic transport systems or the involvement of multiple transport systems for glucuronide conjugates.""?",False, +25685005,Acetaminophen causes neoplasm,4273,No pathologic or statistical evidence of induction of tumors by AAP was found.,"Is the triple ""Acetaminophen causes neoplasm"" supported by the sentence: ""No pathologic or statistical evidence of induction of tumors by AAP was found.""?",False, +24327037,Acetaminophen causes anxiety,4274,"In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.","Is the triple ""Acetaminophen causes anxiety"" supported by the sentence: ""In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposure.""?",False, +23482103,Acetaminophen causes nervous system disorder,4275,"Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.","Is the triple ""Acetaminophen causes nervous system disorder"" supported by the sentence: ""Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.""?",False, +21920646,Acetaminophen causes type 1 diabetes mellitus,4276,"A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.","Is the triple ""Acetaminophen causes type 1 diabetes mellitus"" supported by the sentence: ""A couple of recent studies involving large cohorts have found no association between the use of acetaminophen in early childhood and seroconversion leading to T1DM (TEDDY, involving international cohort) or diagnosis of overt T1DM (Norwegian MoBa) in the follow up years.""?",False, +21160030,Acetaminophen causes Postoperative Nausea and Vomiting,4277,Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.,"Is the triple ""Acetaminophen causes Postoperative Nausea and Vomiting"" supported by the sentence: ""Acetaminophen (1 RCT) was less likely to induce PONV but provided inadequate pain relief compared to morphine and sufentanil.""?",False, +19409287,Acetaminophen causes myopia,4278,ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.,"Is the triple ""Acetaminophen causes myopia"" supported by the sentence: ""ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome.""?",False, +17485084,Acetaminophen causes obesity disorder,4279,Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.,"Is the triple ""Acetaminophen causes obesity disorder"" supported by the sentence: ""Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.""?",False, +17093716,Acetaminophen causes kidney disorder,4280,"PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.","Is the triple ""Acetaminophen causes kidney disorder"" supported by the sentence: ""PURPOSE: The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.""?",False, +16903597,Acetaminophen causes hypertensive disorder,4281,"Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.","Is the triple ""Acetaminophen causes hypertensive disorder"" supported by the sentence: ""Paracetamol and corticosteroids induce hypertension, while steroids also adversely affect the heart from metabolic change as well as fluid retention.""?",False, +16867510,Acetaminophen causes delirium,4282,Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.,"Is the triple ""Acetaminophen causes delirium"" supported by the sentence: ""Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient.""?",False, +16756158,Acetaminophen causes osteoarthritis,4283,"Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.","Is the triple ""Acetaminophen causes osteoarthritis"" supported by the sentence: ""Although, in addition to important nonpharmacological measures, paracetamol is recommended as first-line therapy in osteoarthritis because of its analgesic efficacy and tolerability profile, its efficacy is often disappointing and the more recent guidelines from the European League Against Rheumatism (EULAR) highlight how NSAIDs may be a valid alternative in patients with an inadequate response to paracetamol.""?",False, +16155885,Acetaminophen causes Hemorrhage,4284,"CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.","Is the triple ""Acetaminophen causes Hemorrhage"" supported by the sentence: ""CD39-/- mice had increased APAP-induced hemorrhage and mortality, whereas apyrase also decreased APAP-induced mortality.""?",False, +15922778,Acetaminophen causes Pruritus,4285,"Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.","Is the triple ""Acetaminophen causes Pruritus"" supported by the sentence: ""Therefore, we aimed to create an animal model of APAP-induced pruritus in mice.""?",False, +14972793,Acetaminophen causes brain injury,4286,High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.,"Is the triple ""Acetaminophen causes brain injury"" supported by the sentence: ""High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats.""?",False, +12302511,Acetaminophen causes Headache,4287,"Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.","Is the triple ""Acetaminophen causes Headache"" supported by the sentence: ""Many participants knew that combination analgesic was a common cause of medication-overuse headache, but did not know that ergotamine, acetaminophen and triptans were possible aetiologies of medication-overuse headache.""?",False, +9507087,Acetaminophen causes Vomiting,4288,A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.,"Is the triple ""Acetaminophen causes Vomiting"" supported by the sentence: ""A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose.""?",False, +8697178,Acetaminophen causes Pain,4289,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Pain"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, +8697177,Acetaminophen causes Fever,4290,"Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.","Is the triple ""Acetaminophen causes Fever"" supported by the sentence: ""Paracetamol (500 mg/kg, i.p.), produced similar effect to T. camphoratus and E. africanus on acetic acid-induced writhes but did not affect the pain and the fever produced by the hot-plate and lipopolysaccharide respectively, to any significant extent.""?",False, +7330301,Acetaminophen causes injury,4291,"Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.","Is the triple ""Acetaminophen causes injury"" supported by the sentence: ""Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated their potential role in the pathophysiology of AAP-induced liver injury.""?",False, +24793249,Acetaminophen affects hypertensive disorder,4292,Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.,"Is the triple ""Acetaminophen affects hypertensive disorder"" supported by the sentence: ""Acetaminophen Exacerbates Hypertension: A #NephJC Editorial on PATH-BP.""?",False, +23912807,Acetaminophen affects Vomiting,4293,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, +23912806,Acetaminophen affects Nausea,4294,"METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.","Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""METHODS: We included all randomized controlled trials investigating the effects of the route of administration of acetaminophen on postoperative pain, nausea, and vomiting in patients undergoing general anesthesia.""?",False, +23442508,Acetaminophen affects pharyngitis,4295,"The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.","Is the triple ""Acetaminophen affects pharyngitis"" supported by the sentence: ""The IV administration of paracetamol and dexketoprofen decreased STPIS, DSS, and SwoTS scores over time, while increasing Sore Throat Relief Scale (STRS) scores.""?",False, +23226380,Acetaminophen affects anxiety,4296,"Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.","Is the triple ""Acetaminophen affects anxiety"" supported by the sentence: ""Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure.""?",False, +22849168,Acetaminophen affects neoplasm,4297,The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.,"Is the triple ""Acetaminophen affects neoplasm"" supported by the sentence: ""The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.""?",False, +22389406,Acetaminophen affects Low back pain,4298,"This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.","Is the triple ""Acetaminophen affects Low back pain"" supported by the sentence: ""This narrative review will briefly cover the impacts of LBP, and to provide a summary on recent evidence, updates and a comparison of the Australian and international low back pain management guidelines on paracetamol vs NSAIDs in LBP, as well as pharmacists' roles and interventions in a primary healthcare setting in this context.""?",False, +22267005,Acetaminophen affects Acute Pain,4299,"Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.","Is the triple ""Acetaminophen affects Acute Pain"" supported by the sentence: ""Both the groups were equal in providing sensory pain relief (P = .942), but the treatment was 8.57 times significantly better (P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain.""?",False, +21609859,Acetaminophen affects migraine disorder,4300,The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.,"Is the triple ""Acetaminophen affects migraine disorder"" supported by the sentence: ""The effect of metoclopramide and prochlorperazine on the absorption of effervescent paracetamol in migraine.""?",False, +21375424,Acetaminophen affects preeclampsia,4301,"Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.","Is the triple ""Acetaminophen affects preeclampsia"" supported by the sentence: ""Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.""?",False, +21166764,Acetaminophen affects Parkinson disease,4302,"Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.","Is the triple ""Acetaminophen affects Parkinson disease"" supported by the sentence: ""Here, we highlight CYP3A4, present in the SN, a predominant metabolizer of acetaminophen into its toxic metabolite N-acetyl-p-benzoquinone imine and shown to be regulated in PD.""?",False, +20477729,Acetaminophen affects Hemorrhage,4303,"RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).","Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""RESULTS: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124).""?",False, +20447454,Acetaminophen affects rheumatoid arthritis,4304,"Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.","Is the triple ""Acetaminophen affects rheumatoid arthritis"" supported by the sentence: ""Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.""?",False, +19937801,Acetaminophen affects Pain,4305,Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.,"Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.""?",False, +19285056,Acetaminophen affects Renal Colic,4306,"BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.","Is the triple ""Acetaminophen affects Renal Colic"" supported by the sentence: ""BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial.""?",False, +18899993,Acetaminophen affects Abdominal pain,4307,Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).,"Is the triple ""Acetaminophen affects Abdominal pain"" supported by the sentence: ""Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P=0.02).""?",False, +18709599,Acetaminophen affects Acetimidoquinone,4308,The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.,"Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants.""?",False, +18394888,Acetaminophen affects Headache,4309,"She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.","Is the triple ""Acetaminophen affects Headache"" supported by the sentence: ""She reported a constant tiredness, sporadic slight cephalgia, responsive to acetaminophen, and a recent syncope while jogging, resulting in a fall, circumstances of which she could not recall.""?",False, +18298999,Acetaminophen affects patent ductus arteriosus,4310,Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.,"Is the triple ""Acetaminophen affects patent ductus arteriosus"" supported by the sentence: ""Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.""?",False, +16707575,Acetaminophen affects obesity disorder,4311,"The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.","Is the triple ""Acetaminophen affects obesity disorder"" supported by the sentence: ""The results showed that APAP glucuronidation was enhanced in obese mice, suggesting that changes in APAP metabolism could modify its toxicity in obesity and related fatty liver disease.""?",False, +16662805,Acetaminophen affects Vomiting,4312,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Vomiting"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, +16662804,Acetaminophen affects Nausea,4313,When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.,"Is the triple ""Acetaminophen affects Nausea"" supported by the sentence: ""When compared to placebo tramadol and paracetamol increased the new onset or worsening nausea or vomiting.""?",False, +15922777,Acetaminophen affects Pruritus,4314,Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.,"Is the triple ""Acetaminophen affects Pruritus"" supported by the sentence: ""Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten.""?",False, +15909356,Acetaminophen affects Postoperative Nausea and Vomiting,4315,OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.,"Is the triple ""Acetaminophen affects Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.""?",False, +12673406,Acetaminophen affects bone fracture,4316,"For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).","Is the triple ""Acetaminophen affects bone fracture"" supported by the sentence: ""For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1.45, 95% confidence interval [CI] 1.41-1.49).""?",False, +12488756,Acetaminophen affects Acetaminophen glucuronide,4317,"The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""The substrate inhibition is confirmed by employing stable isotope-labeled APAP as the substrate, while APAP glucuronide is used to test for inhibition of d4-APAP glucuronide.""?",False, +11625632,Acetaminophen affects Chronic pain,4318,The role of paracetamol in chronic pain: an evidence-based approach.,"Is the triple ""Acetaminophen affects Chronic pain"" supported by the sentence: ""The role of paracetamol in chronic pain: an evidence-based approach.""?",False, +11439823,Acetaminophen affects type 1 diabetes mellitus,4319,"The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.","Is the triple ""Acetaminophen affects type 1 diabetes mellitus"" supported by the sentence: ""The effect of insulin-dependent diabetes on hepatobiliary clearance of acetaminophen, bilirubin and digoxin was determined using Sprague-Dawley rats that were treated with a 45 mg/kg dose of streptozotocin 28 days before experimentation.""?",False, +11319146,Acetaminophen affects neuralgia,4320,The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.,"Is the triple ""Acetaminophen affects neuralgia"" supported by the sentence: ""The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain.""?",False, +11289717,Acetaminophen affects osteoarthritis,4321,"Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.","Is the triple ""Acetaminophen affects osteoarthritis"" supported by the sentence: ""Pain symptoms of osteoarthritis can be positively influenced by paracetamol and NSAR, in combination with orthopedic aids and physical therapy in early stages.""?",False, +11227783,Acetaminophen affects Fever,4322,Young age and high fever were associated with significantly higher acetaminophen levels.,"Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Young age and high fever were associated with significantly higher acetaminophen levels.""?",False, +11159989,Acetaminophen affects Hemorrhage,4323,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?",False, +10410536,Acetaminophen affects injury,4324,Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).,"Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP).""?",False, +10195419,Acetaminophen affects Pain,4325,"The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.","Is the triple ""Acetaminophen affects Pain"" supported by the sentence: ""The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.""?",False, +9259287,Acetaminophen affects Fever,4326,"Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.","Is the triple ""Acetaminophen affects Fever"" supported by the sentence: ""Ibuprofen, acetylsalicylic acid (ASA) and acetaminophen are the most frequently used agents for fever reduction in children.""?",False, +8642669,Acetaminophen affects Hemorrhage,4327,CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.,"Is the triple ""Acetaminophen affects Hemorrhage"" supported by the sentence: ""CONCLUSION: Preoperative rectal diclofenac offers no advantage over paracetamol with respect to postoperative analgesia in tonsillectomy patients but increases intraoperative blood loss.""?",False, +8097597,Acetaminophen affects injury,4328,"These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.","Is the triple ""Acetaminophen affects injury"" supported by the sentence: ""These results suggest that direct oxidative injury serves as a general trigger for apoptosis in the liver, and that other apoptotic stimuli, such as exposure to acetaminophen, also involve oxidative injury.""?",False, +25639149,Acetaminophen affects Acetaminophen glucuronide,4329,"Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.","Is the triple ""Acetaminophen affects Acetaminophen glucuronide"" supported by the sentence: ""Decreases produced by ether in the in vivo production of acetaminophen glucuronide correlated with increasing plasma concentrations of unmetabolised acetaminophen, decreasing hepatic GSH content and increasing covalent binding of acetaminophen to hepatocellular protein when these measurements were performed in the same animals.""?",False, +20782169,Acetaminophen affects Acetimidoquinone,4330,"Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.","Is the triple ""Acetaminophen affects Acetimidoquinone"" supported by the sentence: ""Pretreatment of liver extracts with the sulfhydryl-specific reagent, N-ethylmaleimide (NEM), prior to derivatization with the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), greatly reduced immunochemically detectable APAP-protein adducts and indicated that the antibody detects protein-thiol conjugates of APAP.""?",False, +25481457,Acetaminophen disrupts patent ductus arteriosus,4331,"Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.","Is the triple ""Acetaminophen disrupts patent ductus arteriosus"" supported by the sentence: ""Within 24 hours of restarting the acetaminophen, the repeated ECHO showed a reduction in PDA and flow.""?",False, +25355292,Acetaminophen disrupts delirium,4332,"Individually, acetaminophen was associated with reduced delirium.","Is the triple ""Acetaminophen disrupts delirium"" supported by the sentence: ""Individually, acetaminophen was associated with reduced delirium.""?",False, +19614622,Acetaminophen disrupts Headache,4333,The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.,"Is the triple ""Acetaminophen disrupts Headache"" supported by the sentence: ""The primary outcome measure of the efficacy of parenteral acetaminophen as an adjunct treatment for headache in addition to a standard therapy was a threshold two-point reduction in visual analog scale (VAS) pain scores on a 1-10 level at 90 minutes.""?",False, +16273113,Acetaminophen disrupts Fever,4334,"Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.","Is the triple ""Acetaminophen disrupts Fever"" supported by the sentence: ""Intravenous acetaminophen received United States Food and Drug Administration approval in November 2010 for the management of mild-to-moderate pain, management of moderate-to-severe pain with adjunctive opioid analgesics, and reduction of fever.""?",False, +12102031,Acetaminophen disrupts Pain,4335,Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.,"Is the triple ""Acetaminophen disrupts Pain"" supported by the sentence: ""Sustained release (SR) formulations of paracetamol (acetaminophen) have been introduced in several countries to provide lasting pain relief and reduced risk of rebound pain.""?",False, +7794905,Acetaminophen disrupts influenza,4336,"Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.","Is the triple ""Acetaminophen disrupts influenza"" supported by the sentence: ""Benefit of zanamivir treatment in terms of time to return to normal activities and reductions in consumption of paracetamol (acetaminophen), and reductions in the level of interference of influenza with sleep, work, leisure and recreational activities, were reported.""?",False, +7640332,Acetaminophen disrupts injury,4337,"RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).","Is the triple ""Acetaminophen disrupts injury"" supported by the sentence: ""RESULTS: Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14,070 U/L, range 5980 to 27,680 for AST; 49 U/L, range 41 to 64 vs. 15,330 U/L, range 13,920 to 15,940 for ALT).""?",False, +26559635,Acetaminophen prevents malaria,4338,Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.,"Is the triple ""Acetaminophen prevents malaria"" supported by the sentence: ""Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria.""?",False, +22159381,Acetaminophen prevents Hemorrhage,4339,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.","Is the triple ""Acetaminophen prevents Hemorrhage"" supported by the sentence: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?",False, +22123298,Acetaminophen prevents Fever,4340,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,"Is the triple ""Acetaminophen prevents Fever"" supported by the sentence: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?",False, +20154151,Acetaminophen prevents neuralgia,4341,"Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.","Is the triple ""Acetaminophen prevents neuralgia"" supported by the sentence: ""Together the results suggest that a high dose of paracetamol increases anxiety-like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury-associated anxiety probably by reducing neuropathic pain.""?",False, +20107193,Acetaminophen prevents delirium,4342,The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.,"Is the triple ""Acetaminophen prevents delirium"" supported by the sentence: ""The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study.""?",False, +19168014,Acetaminophen prevents obesity disorder,4343,AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.,"Is the triple ""Acetaminophen prevents obesity disorder"" supported by the sentence: ""AIM: Local Guidelines for peri-operative pain management in children published in 2012 recommended that paracetamol dosing was calculated using ideal body weight (IBW) to prevent inadvertent overdosing in overweight and obese children.1 The purpose of this audit was to establish compliance with these guidelines.""?",False, +19006111,Acetaminophen prevents patent ductus arteriosus,4344,Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.,"Is the triple ""Acetaminophen prevents patent ductus arteriosus"" supported by the sentence: ""Further trials are required to determine whether intravenous paracetamol may safely prevent symptomatic patent ductus arteriosus.""?",False, +18131378,Acetaminophen prevents Low back pain,4345,CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.,"Is the triple ""Acetaminophen prevents Low back pain"" supported by the sentence: ""CONCLUSIONS: This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression.""?",False, +18033682,Acetaminophen prevents Vomiting,4346,"Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).","Is the triple ""Acetaminophen prevents Vomiting"" supported by the sentence: ""Weighted mean difference (95% CI) of -9.7 (-13.0 to -6.4) mg morphine intravenous equivalents systemic acetaminophen also reduced postoperative nausea and vomiting compared with control, odds ratio (95% CI) of 0.25 (0.13 to 0.47), numbers needed to treat (95% CI)=3.3 (2.3 to 5.9).""?",False, +16975983,Acetaminophen prevents neoplasm,4347,Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.,"Is the triple ""Acetaminophen prevents neoplasm"" supported by the sentence: ""Acetaminophen enhanced the cisplatin chemotherapeutic effect by reducing tumor recurrence.""?",False, +16828191,Acetaminophen prevents rheumatoid arthritis,4348,"RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.","Is the triple ""Acetaminophen prevents rheumatoid arthritis"" supported by the sentence: ""RESULTS: After intake of acetaminophen, pain thresholds increased slightly in CFS/FM patients, and decreased in the RA and the control group.""?",False, +16784082,Acetaminophen prevents injury,4349,Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.,"Is the triple ""Acetaminophen prevents injury"" supported by the sentence: ""Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.""?",False, +16782348,Acetaminophen prevents Nausea,4350,"When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).","Is the triple ""Acetaminophen prevents Nausea"" supported by the sentence: ""When i.v. acetaminophen was given prophylactically, the reduction of nausea correlated with the reduction of pain (odds ratio 0.66, 0.47-0.93), but not with reduction in postoperative opioids (odds ratio 0.89, 0.64-1.22).""?",False, +15909357,Acetaminophen prevents Postoperative Nausea and Vomiting,4351,CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.,"Is the triple ""Acetaminophen prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.""?",False, +15525446,Acetaminophen prevents Acute Pain,4352,Review: acetaminophen reduces acute migraine pain in adults.,"Is the triple ""Acetaminophen prevents Acute Pain"" supported by the sentence: ""Review: acetaminophen reduces acute migraine pain in adults.""?",False, +15467414,Acetaminophen prevents influenza,4353,METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.,"Is the triple ""Acetaminophen prevents influenza"" supported by the sentence: ""METHODS: A mouse model of influenza infection was utilised to assess the efficacy of paracetamol (acetaminophen) in reducing influenza-induced pathology and to examine whether paracetamol affects generation of protective immunity.""?",False, +14660734,Acetaminophen prevents cardiac rhythm disease,4354,"This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.","Is the triple ""Acetaminophen prevents cardiac rhythm disease"" supported by the sentence: ""This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils.""?",False, +14372292,Acetaminophen prevents Headache,4355,"Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.","Is the triple ""Acetaminophen prevents Headache"" supported by the sentence: ""Flunarizine may be valuable in paediatric headache prevention, and ibuprofen, acetaminophen and nasal sumatriptan may be effective in the acute management of headaches.""?",False, +13804263,Acetaminophen prevents type 2 diabetes mellitus,4356,"We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.","Is the triple ""Acetaminophen prevents type 2 diabetes mellitus"" supported by the sentence: ""We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.""?",False, +8695490,Acetaminophen prevents Pain,4357,"Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.","Is the triple ""Acetaminophen prevents Pain"" supported by the sentence: ""Although paracetamol potently reduces pain and fever, its mechanism of action has so far not been satisfactorily explained.""?",False, +25567880,Acetaminophen predisposes Sepsis,4358,Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?,"Is the triple ""Acetaminophen predisposes Sepsis"" supported by the sentence: ""Does Fever Response to Acetaminophen Predict Bloodstream Infections in Febrile Neutropenia?""?",False, +24917204,Acetaminophen predisposes type 2 diabetes mellitus,4359,"CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.","Is the triple ""Acetaminophen predisposes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Regular use of paracetamol, but not ibuprofen, was associated with a significantly higher risk of incident T2DM among middle aged UK adults.""?",False, +22230555,Acetaminophen predisposes delirium,4360,"Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.","Is the triple ""Acetaminophen predisposes delirium"" supported by the sentence: ""Univariate logistic regression analysis indicated that advanced age, comorbidity, cognitive impairment, dementia, American Society of Anaesthesiologist score, antipsychotic usage were significant risk factors for delirium while doses of paracetamol, fentanyl and diazepam showed complex associations.""?",False, +21723139,Acetaminophen predisposes Hemorrhage,4361,"Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.","Is the triple ""Acetaminophen predisposes Hemorrhage"" supported by the sentence: ""Heavy alcohol use (hazard ratio [HR]=2.37; 95% CI 1.24-4.53); uncontrolled hypertension (HR after parameter-wise shrinkage=1.79; 95% CI 1.05-3.05); and concomitant treatment with antiplatelets, nonsteroidal anti-inflammatory drugs, or paracetamol (HR=1.80; 95% CI 1.24-2.61) were identified as modifiable, independent bleeding risk factors.""?",False, +20594449,Acetaminophen predisposes neoplasm,4362,"The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).","Is the triple ""Acetaminophen predisposes neoplasm"" supported by the sentence: ""The aim was to examine serous borderline tumor (SBT) or mucinous borderline tumor (MBT) risk associated with use of paracetamol, low-dose aspirin, or non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs).""?",False, +19914508,Acetaminophen predisposes Pain,4363,"Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.","Is the triple ""Acetaminophen predisposes Pain"" supported by the sentence: ""Current approaches to pain management in OA have been rather non-specific, limited to acetaminophen or NSAIDs primarily, without targeting underlying structural lesions that may be contributing to pain in OA.""?",False, +16209480,Acetaminophen predisposes kidney disorder,4364,Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).,"Is the triple ""Acetaminophen predisposes kidney disorder"" supported by the sentence: ""Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0.900).""?",False, +13597848,Acetaminophen predisposes injury,4365,"After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.","Is the triple ""Acetaminophen predisposes injury"" supported by the sentence: ""After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury.""?",False, +13536066,Acetaminophen predisposes non-small cell lung carcinoma,4366,"METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.","Is the triple ""Acetaminophen predisposes non-small cell lung carcinoma"" supported by the sentence: ""METHODS: Through a case-control study of African American and Caucasian women with and without NSCLC, we examined the relationship between use of aspirin, NSAIDs, and acetaminophen and risk of NSCLC.""?",False, +12673403,Acetaminophen predisposes bone fracture,4367,"Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.","Is the triple ""Acetaminophen predisposes bone fracture"" supported by the sentence: ""Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.""?",False, +12109634,Acetaminophen predisposes Parkinson disease,4368,"No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.","Is the triple ""Acetaminophen predisposes Parkinson disease"" supported by the sentence: ""No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk.""?",False, +11873681,Acetaminophen predisposes non-Hodgkin lymphoma,4369,"Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.","Is the triple ""Acetaminophen predisposes non-Hodgkin lymphoma"" supported by the sentence: ""Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.""?",False, +9834508,Acetaminophen predisposes hypertensive disorder,4370,"CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.","Is the triple ""Acetaminophen predisposes hypertensive disorder"" supported by the sentence: ""CONCLUSIONS: Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.""?",False, +8862839,Acetaminophen predisposes streptococcal infection,4371,Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.,"Is the triple ""Acetaminophen predisposes streptococcal infection"" supported by the sentence: ""Subgroup analyses revealed that the risk of invasive GAS infection was increased only among children who had received both acetaminophen and ibuprofen.""?",False, +10289439,Chlorthalidone related to hypertensive disorder,4372,Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.,"Is the triple ""Chlorthalidone related to hypertensive disorder"" supported by the sentence: ""Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.""?",False, +10185607,Chlorthalidone related to coronary artery disorder,4373,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to coronary artery disorder"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, +10185606,Chlorthalidone related to myocardial infarction,4374,No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.,"Is the triple ""Chlorthalidone related to myocardial infarction"" supported by the sentence: ""No significance differences were reported for amlodipine versus chlorthalidone or lisinopril versus chlorthalidone on the primary outcome of combined incidence of fatal CHD and nonfatal myocardial infarction.""?",False, +7839079,Chlorthalidone related to essential hypertension,4375,Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.,"Is the triple ""Chlorthalidone related to essential hypertension"" supported by the sentence: ""Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume.""?",False, +21616164,Chlorthalidone affects myocardial infarction,4376,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects myocardial infarction"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, +21616163,Chlorthalidone affects coronary artery disorder,4377,"METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).","Is the triple ""Chlorthalidone affects coronary artery disorder"" supported by the sentence: ""METHODS: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized clinical trial on the effects of first-step hypertension therapy with amlodipine, chlorthalidone, or lisinopril on fatal coronary heart disease or nonfatal myocardial infarction (1994-2002).""?",False, +16399514,Chlorthalidone affects essential hypertension,4378,"In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.","Is the triple ""Chlorthalidone affects essential hypertension"" supported by the sentence: ""In this study the clinical, biological, radiologic, electrocardiographic, and hormonal characteristics of 80 patients with slight or moderate essential arterial hypertension in whom the treatment with atenolol alone or associated with chlorthalidone or with a third agent normalized the arterial pressure during a period of one year, are revised.""?",False, +16281975,Chlorthalidone affects hypertensive disorder,4379,"In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.","Is the triple ""Chlorthalidone affects hypertensive disorder"" supported by the sentence: ""In conclusion, SR nicardipine was found to be more efficacious than chlorthalidone in controlling not only BP but also the arrhythmic events related to hypertension.""?",False, +11587035,Chlorthalidone affects diabetes mellitus,4380,Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.,"Is the triple ""Chlorthalidone affects diabetes mellitus"" supported by the sentence: ""Subjects who had diabetes associated with chlorthalidone had no significant increase in CV events and had a better prognosis than did those who had preexisting diabetes.""?",False, +11095498,Chlorthalidone prevents myocardial infarction,4381,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents myocardial infarction"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, +11095497,Chlorthalidone prevents coronary artery disorder,4382,"The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.","Is the triple ""Chlorthalidone prevents coronary artery disorder"" supported by the sentence: ""The results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which compared agents of three groups of new antihypertensive drugs with a diuretic, demonstrated the equivalence between these drugs and chlorthalidone (Tenoretic AstraZeneca) in the prevention of incident fatal coronary heart disease and nonfatal myocardial infarction.""?",False, +8853238,Chlorthalidone prevents myocardial ischemia,4383,"CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.","Is the triple ""Chlorthalidone prevents myocardial ischemia"" supported by the sentence: ""CONCLUSION: In elderly hypertensive patients with coronary artery disease, chlorthalidone reduced myocardial ischemia similarly to diltiazem.""?",False, +8036244,Chlorthalidone prevents hypertensive disorder,4384,"Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.","Is the triple ""Chlorthalidone prevents hypertensive disorder"" supported by the sentence: ""Chlorthalidone reversed or prevented the DOCA-salt-induced hypertension, which was accompanied by the normalization of both the arterial baroreflex and the Bezold-Jarisch reflex.""?",False, +11078982,Chlorthalidone predisposes coronary artery disorder,4385,"The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.","Is the triple ""Chlorthalidone predisposes coronary artery disorder"" supported by the sentence: ""The authors conclude that treatment of hypertension with doxazosin in adults with glucose disorders incurs the same risk of coronary heart disease as treatment with chlorthalidone; however, treatment with doxazosin increases the risk of combined cardiovascular disease and heart failure despite lower glucose levels.""?",False, +19123757,Propacetamol causes Pain,4386,"In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.","Is the triple ""Propacetamol causes Pain"" supported by the sentence: ""In conclusion, activation of human TRPV1 by PPCM seems to be a relevant mechanism for induction of pain upon intracutaneous injection and thus also for pain reported as an adverse side effect upon intravenous administration.""?",False, +11402898,Propacetamol prevents Pain,4387,BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.,"Is the triple ""Propacetamol prevents Pain"" supported by the sentence: ""BACKGROUND: Postoperative administration of paracetamol or its prodrug propacetamol has been shown to decrease pain with a morphine sparing effect.""?",False, +25540651,Isopropyl Alcohol affects Nausea,4388,"CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.","Is the triple ""Isopropyl Alcohol affects Nausea"" supported by the sentence: ""CONCLUSION: This review suggests that IPA likely has a modest effect in reducing nausea in adult ED patients, compared with placebo.""?",False, +18311094,Isopropyl Alcohol affects infectious disease,4389,CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.,"Is the triple ""Isopropyl Alcohol affects infectious disease"" supported by the sentence: ""CONCLUSIONS: The use of 2.0% chlorhexidine with 70.0% isopropyl alcohol versus 0.7% iodine povacrylex with 74.0% isopropyl alcohol or alcohol-based versus nonalcohol-based skin preparations does not significantly influence the incidence of surgical site infections or readmission within 30 days for surgical site infection after clean-contaminated colorectal operations.""?",False, +10697335,Isopropyl Alcohol affects burn,4390,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Isopropyl Alcohol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, +9427033,Isopropyl Alcohol prevents infectious disease,4391,"The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.","Is the triple ""Isopropyl Alcohol prevents infectious disease"" supported by the sentence: ""The valve is designed to allow cleansing of the valve, valve pocket, and buttonhole site with 70% isopropyl alcohol before and after each use to minimize the risk of infection.""?",False, +21320482,Ethanol related to substance-related disorder,4392,"METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).","Is the triple ""Ethanol related to substance-related disorder"" supported by the sentence: ""METHODS: Trends were analyzed in the consumption of tobacco, alcohol, cannabis and other illegal drugs, analgesics, and hypnotics/sedatives, as well as trends in substance-related disorders, as coded according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).""?",False, +15908919,Ethanol related to hypertensive disorder,4393,"Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.","Is the triple ""Ethanol related to hypertensive disorder"" supported by the sentence: ""Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron.""?",False, +14538852,Ethanol related to atrial fibrillation,4394,CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.,"Is the triple ""Ethanol related to atrial fibrillation"" supported by the sentence: ""CONCLUSIONS: Alcohol and illicit drugs are arrhythmogenic and are associated with atrial fibrillation.""?",False, +13852361,Ethanol related to obesity disorder,4395,"Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.","Is the triple ""Ethanol related to obesity disorder"" supported by the sentence: ""Recent reports from the developed world indicate a high association with obesity, tobacco and alcohol, habits which though not currently very popular in the third world are nevertheless increasingly accepted.""?",False, +27116018,Ethanol causes neutropenia,4396,"EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.","Is the triple ""Ethanol causes neutropenia"" supported by the sentence: ""EtOH caused neutropenia following trauma, relative to LR solution, but the IV versus PO differences could not be discriminated on the basis of neutrophil or lymphocytes counts, nor CD18 receptor expression, nor renal or hepatic dysfunction.""?",False, +26520376,Ethanol causes essential hypertension,4397,"Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.","Is the triple ""Ethanol causes essential hypertension"" supported by the sentence: ""Arguments as to whether alcohol is a cause of essential hypertension are tautological, given the many reversible lifestyle factors now known to contribute to the rise in blood pressure with aging.""?",False, +17336935,Ethanol causes Tremor,4398,"We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.","Is the triple ""Ethanol causes Tremor"" supported by the sentence: ""We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase ""shaken, not stirred"" could be because of alcohol induced tremor affecting his hands.""?",False, +15073107,Ethanol causes alcohol-related disorders,4399,"CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.","Is the triple ""Ethanol causes alcohol-related disorders"" supported by the sentence: ""CONCLUSION: Taken as a whole, the available evidence suggests that the positive association of alcohol with increased cardiovascular disease mortality may be best explained as being the result of a combination of chronic and acute alcohol consumption resulting in alcohol-related cardiac disorders, especially cardiomyopathy, rather than being due to misclassification of acute alcohol poisoning.""?",False, +14779551,Ethanol causes burn,4400,CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.,"Is the triple ""Ethanol causes burn"" supported by the sentence: ""CONCLUSION: Burns caused by alcohol-based fires in household coal stoves is a common thermal injury in the middle of Anhui Province in China with characteristic clinical presentation and calls for preventive educational intervention.""?",False, +12227250,Ethanol causes bacterial infectious disease with sepsis,4401,Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.,"Is the triple ""Ethanol causes bacterial infectious disease with sepsis"" supported by the sentence: ""Ethanol had no effect on neutrophil migration in enzyme histochemistry analysis CONCLUSIONS: The above observations suggest that ethanol induced physical disruption of the intestine but not neutrophil transmigration is the main cause of the bacterial translocation that leads to bacteremia and endotoxemia in alcoholics.""?",False, +11665347,Ethanol causes erectile dysfunction,4402,"Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.","Is the triple ""Ethanol causes erectile dysfunction"" supported by the sentence: ""Alcohol can interfere with the function of each of these components, thereby causing impotence, infertility, and reduced male secondary sexual characteristics.""?",False, +11096896,Ethanol causes type 2 diabetes mellitus,4403,"Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.","Is the triple ""Ethanol causes type 2 diabetes mellitus"" supported by the sentence: ""Therefore, cloning of these genes in full-length and the detailed studies of each gene on beta-cell functions might provide clues on the pathophysiology of type 2 diabetes caused by alcohol.""?",False, +10962858,Ethanol causes atrial fibrillation,4404,This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.,"Is the triple ""Ethanol causes atrial fibrillation"" supported by the sentence: ""This study investigated whether ethanol may induce atrial fibrillation through increasing arrhythmogenic activity of pulmonary vein cardiomyocytes.""?",False, +9159992,Ethanol causes obesity disorder,4405,"In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.","Is the triple ""Ethanol causes obesity disorder"" supported by the sentence: ""In contrast to high energy diet, ethanol induced neither development of obesity nor exaggeration of diabetic states.""?",False, +8743651,Ethanol causes alcohol abuse,4406,"Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.","Is the triple ""Ethanol causes alcohol abuse"" supported by the sentence: ""Clinical reports suggest that individuals with social anxiety disorder often use alcohol to alleviate anxiety symptoms, a practice that leads to alcohol abuse and/or dependence in approximately 20% of affected individuals.""?",False, +8636726,Ethanol causes major depressive disorder,4407,"For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.","Is the triple ""Ethanol causes major depressive disorder"" supported by the sentence: ""For a current drinker, a positive IDD does not distinguish between an alcohol-induced depression and MDD.""?",False, +8268450,Ethanol causes atopic eczema,4408,Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.,"Is the triple ""Ethanol causes atopic eczema"" supported by the sentence: ""Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases.""?",False, +7771647,Ethanol causes hypertensive disorder,4409,High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.,"Is the triple ""Ethanol causes hypertensive disorder"" supported by the sentence: ""High D2O concentrations can reduce salt- and ethanol-induced hypertension in rats and protect mice from gamma irradation.""?",False, +7460012,Ethanol causes cirrhosis of liver,4410,[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].,"Is the triple ""Ethanol causes cirrhosis of liver"" supported by the sentence: ""[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].""?",False, +27580478,Ethanol affects cirrhosis of liver,4411,CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.,"Is the triple ""Ethanol affects cirrhosis of liver"" supported by the sentence: ""CONCLUSIONS: Alcohol is the risk factor with the highest impact on symptomatic liver cirrhosis risk in Italy.""?",False, +27514790,Ethanol affects Thyroid nodule,4412,"In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.","Is the triple ""Ethanol affects Thyroid nodule"" supported by the sentence: ""In conclusion, the effect of PEI on ATNs can be evaluated with an MR examination that is not very time consuming.""?",False, +26762447,Ethanol affects neutropenia,4413,"To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).","Is the triple ""Ethanol affects neutropenia"" supported by the sentence: ""To examine whether neutrophils play a role in the development of experimental colitides, the effects of a sustained neutropenia on multiple indices of colonic injury in rats was examined 24 hr following the initiation of colitis with the intrarectal application of acetic acid, trinitrobenzene sulfonic acid (TNBS)-ethanol, or the potent proinflammatory agent, phorbol-12-myristate-13-acetate (PMA).""?",False, +23912654,Ethanol affects atrial fibrillation,4414,"Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""Acute exposure to alcohol increased AF risk, with no evidence that other exposures, including caffeine, more commonly triggered AF.""?",False, +23763968,Ethanol affects substance-related disorder,4415,"CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.","Is the triple ""Ethanol affects substance-related disorder"" supported by the sentence: ""CONTEXT: Assessing temporal changes in the recorded diagnostic rates, incidence proportions, and health outcomes of substance-related disorders (SRD) can inform public health policymakers in reducing harms associated with alcohol and other drugs.""?",False, +19533165,Ethanol affects hypertensive disorder,4416,"As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.","Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""As in younger subjects, heavy consumption, or abuse of alcohol, negates any potential protective cardiovascular effects, increasing the incidence of heart failure and hypertension.""?",False, +19155713,Ethanol affects cannabis dependence,4417,"Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.","Is the triple ""Ethanol affects cannabis dependence"" supported by the sentence: ""Logistic regression models were computed to examine eight distinct outcomes: alcohol abuse, illicit drug abuse, marijuana/hashish abuse, comorbid alcohol and illicit drug abuse, alcohol dependence, illicit drug dependence, marijuana/hashish dependence, and comorbid alcohol and illicit drug dependence.""?",False, +16819917,Ethanol affects Chronic pain,4418,"INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""INTRODUCTION: Although alcohol consumption is a common lifestyle behavior with previous studies reporting positive effects of alcohol on chronic pain and rheumatoid arthritis, no studies to this date have examined alcohol consumption in patients with fibromyalgia.""?",False, +15671844,Ethanol affects obesity disorder,4419,"The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk.""?",False, +14737169,Ethanol affects Chronic pain,4420,"Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.","Is the triple ""Ethanol affects Chronic pain"" supported by the sentence: ""Increasing age, low income, low educational achievement, daily cigarette smoking, physical inactivity and abstention from alcohol were among the factors found to increase CNCP risk.""?",False, +14527564,Ethanol affects benign prostatic hyperplasia,4421,Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.,"Is the triple ""Ethanol affects benign prostatic hyperplasia"" supported by the sentence: ""Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.""?",False, +13226372,Ethanol affects atrial fibrillation,4422,"BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.","Is the triple ""Ethanol affects atrial fibrillation"" supported by the sentence: ""BACKGROUND: Alcohol has been related to atrial fibrillation (holiday heart syndrome), but its electrophysiologic actions remain unclear.""?",False, +12698965,Ethanol affects major depressive disorder,4423,"An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""An increased risk of developing psychiatric disorders, like major depression and impulse-control-related pathologies is associated with alcohol exposure during fetal life and/or during adolescence.""?",False, +12166837,Ethanol affects type 2 diabetes mellitus,4424,Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""Ethanol has been considered as a lifestyle factor that may influence the risk of type 2 diabetes mellitus.""?",False, +10697334,Ethanol affects burn,4425,"STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns.""?",False, +9822489,Ethanol affects Tremor,4426,"Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""Ethanol dependence, characterized by a spectrum of withdrawal signs and reactions of progressively increasing severity as blood ehtanol concentration approached 100 mg/dl: hyperactivity, tremors, akinesia, spastic rigidity, and induced and spontaneous convulsions.""?",False, +9174558,Ethanol affects Tremor,4427,"The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.","Is the triple ""Ethanol affects Tremor"" supported by the sentence: ""The severity of the tremor varied considerably from patient to patient, and often was temporarily lessened by alcohol.""?",False, +9116052,Ethanol affects major depressive disorder,4428,"RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.","Is the triple ""Ethanol affects major depressive disorder"" supported by the sentence: ""RESULTS: Significant linear associations were found between the number of anxiety disorders reported in adolescence and later risks of anxiety disorder; major depression; nicotine, alcohol, and illicit drug dependence; suicidal behavior; educational underachievement; and early parenthood.""?",False, +8931619,Ethanol affects hypertensive disorder,4429,The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.,"Is the triple ""Ethanol affects hypertensive disorder"" supported by the sentence: ""The increased relative risk for hypertension associated with alcohol was more pronounced in leaner men.""?",False, +8730041,Ethanol affects burn,4430,"Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.","Is the triple ""Ethanol affects burn"" supported by the sentence: ""Consumption of alcohol increased the length of time people spent smoking, increased the number of puffs taken on each cigarette, and increased the amount of tobacco burnt.""?",False, +8616967,Ethanol affects type 2 diabetes mellitus,4431,CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.,"Is the triple ""Ethanol affects type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: The results indicated that high consumption of alcohol increases the occurrence of Type 2 diabetes and that this may primarily concern consumption of beer and spirits.""?",False, +8569555,Ethanol affects alcohol abuse,4432,"This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""This study examined the associations between alcohol abuse or dependence and early experience of alcohol as measured on retrospective SRE score (relating to the first five times alcohol was imbibed), and the presence of alcohol abuse or dependence, in patients attending primary care.""?",False, +8363507,Ethanol affects obesity disorder,4433,"Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.","Is the triple ""Ethanol affects obesity disorder"" supported by the sentence: ""Alcohol, on the other hand, is poorly satiating and may replace fat in oxidative processes, thus enhancing the risk of obesity.""?",False, +7210977,Ethanol affects alcohol abuse,4434,"CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.","Is the triple ""Ethanol affects alcohol abuse"" supported by the sentence: ""CONCLUSIONS: The current study confirmed that COAs, particularly those whose parents are alcohol dependent as opposed to having a diagnosis of alcohol abuse, achieve relatively lower academic outcomes in comparison to non-COA peers.""?",False, +25366419,Ethanol disrupts ventricular tachycardia,4435,"However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.","Is the triple ""Ethanol disrupts ventricular tachycardia"" supported by the sentence: ""However, saline solution and 25% ethyl alcohol suppressed ventricular tachycardia only transiently in 8 (53%) of 15 and 3 (60%) of 5 dogs, respectively.""?",False, +24747388,Ethanol disrupts obesity disorder,4436,"In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.","Is the triple ""Ethanol disrupts obesity disorder"" supported by the sentence: ""In conclusion, our results show for the first time that alcohol can trigger the browning of white adipose tissue to counteract obesity.""?",False, +22793590,Ethanol disrupts Infection,4437,"In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.","Is the triple ""Ethanol disrupts Infection"" supported by the sentence: ""In direct contrast to healthcare settings, where frequent use of alcohol-based hand sanitizers (ABHSs) in lieu of handwashing has improved hand hygiene compliance rates and reduced infections, the Food Code continues to permit the use of ABHSs only after hands have been washed with soap and water.""?",False, +20664067,Ethanol disrupts Chronic pain,4438,"Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).","Is the triple ""Ethanol disrupts Chronic pain"" supported by the sentence: ""Weekly consumption of alcohol was associated with reduced risk of CWP (OR 0.33, 0.31-0.35), but instrumental variable analysis did not show a causal effect of alcohol consumption on reducing CWP (OR 1.29, 0.96-1.74).""?",False, +19084276,Ethanol disrupts hypertensive disorder,4439,"Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.","Is the triple ""Ethanol disrupts hypertensive disorder"" supported by the sentence: ""Thus, although continuous drinking of alcohol does not lower blood pressure, it appears to counteract the development of hypertension in rats.""?",False, +15586620,Ethanol disrupts Tremor,4440,Temporary suppression of the tremor by alcohol is seen in about one-third of cases.,"Is the triple ""Ethanol disrupts Tremor"" supported by the sentence: ""Temporary suppression of the tremor by alcohol is seen in about one-third of cases.""?",False, +15580442,Ethanol disrupts atrial fibrillation,4441,"In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).","Is the triple ""Ethanol disrupts atrial fibrillation"" supported by the sentence: ""In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles).""?",False, +12535146,Ethanol disrupts type 2 diabetes mellitus,4442,Alcohol from wine was associated with reduced risk of Type 2 diabetes.,"Is the triple ""Ethanol disrupts type 2 diabetes mellitus"" supported by the sentence: ""Alcohol from wine was associated with reduced risk of Type 2 diabetes.""?",False, +9920913,Ethanol disrupts constipation disorder,4443,"Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).","Is the triple ""Ethanol disrupts constipation disorder"" supported by the sentence: ""Walking was a preventive factor for constipation among males ( p = 0.049), and alcohol also inhibited constipation among males ( p = 0.007).""?",False, +27717904,Ethanol prevents cirrhosis of liver,4444,HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.,"Is the triple ""Ethanol prevents cirrhosis of liver"" supported by the sentence: ""HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.""?",False, +22976273,Ethanol prevents Infection,4445,Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.,"Is the triple ""Ethanol prevents Infection"" supported by the sentence: ""Studies on MRSA epidemiology had shown that community-acquired MRSA (CA-MRSA) was disseminated into hospitals and that an increased use of alcohol-based rubs could reduce the incidence of MRSA infections in such institutions.""?",False, +21338360,Ethanol prevents atrial fibrillation,4446,Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.,"Is the triple ""Ethanol prevents atrial fibrillation"" supported by the sentence: ""Avoiding the habit of consuming a low but frequent amount of alcohol might therefore be important to prevent AF.""?",False, +20664068,Ethanol prevents Chronic pain,4447,An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.,"Is the triple ""Ethanol prevents Chronic pain"" supported by the sentence: ""An interpretation of observational population studies as showing a protective effect of alcohol on CWP is not supported.""?",False, +14465260,Ethanol prevents bacterial infectious disease with sepsis,4448,Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.,"Is the triple ""Ethanol prevents bacterial infectious disease with sepsis"" supported by the sentence: ""Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion.""?",False, +13158318,Ethanol prevents erectile dysfunction,4449,More research is needed to confirm whether alcohol is protective or is unrelated to ED development.,"Is the triple ""Ethanol prevents erectile dysfunction"" supported by the sentence: ""More research is needed to confirm whether alcohol is protective or is unrelated to ED development.""?",False, +12078103,Ethanol prevents alcohol abuse,4450,"Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.","Is the triple ""Ethanol prevents alcohol abuse"" supported by the sentence: ""Results of these studies generally fall under one of the following themes: (1) alcohol is an integral part of leisure experience, (2) drinking is an impediment to leisure, (3) participation in active leisure reduces alcohol use/abuse, and (4) drinking and leisure have no relations.""?",False, +11890775,Ethanol prevents type 2 diabetes mellitus,4451,Alcohol for the prevention of type 2 diabetes mellitus?,"Is the triple ""Ethanol prevents type 2 diabetes mellitus"" supported by the sentence: ""Alcohol for the prevention of type 2 diabetes mellitus?""?",False, +11547578,Ethanol prevents Tremor,4452,"Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.","Is the triple ""Ethanol prevents Tremor"" supported by the sentence: ""Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor.""?",False, +10032139,Ethanol prevents obesity disorder,4453,"During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.","Is the triple ""Ethanol prevents obesity disorder"" supported by the sentence: ""During nonselective beta-, beta(1)- and beta(2)-adrenergic stimulation, interstitial glycerol concentrations increased and ethanol out/in ratios decreased similarly in obese and lean men.""?",False, +8207881,Ethanol prevents hypertensive disorder,4454,Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.,"Is the triple ""Ethanol prevents hypertensive disorder"" supported by the sentence: ""Oral taurine supplementation (1% taurine and 15% ethanol in drinking water) completely prevented the development of ethanol-induced hypertension.""?",False, +26228661,Ethanol predisposes essential hypertension,4455,"Alcohol, personality and predisposition to essential hypertension.","Is the triple ""Ethanol predisposes essential hypertension"" supported by the sentence: ""Alcohol, personality and predisposition to essential hypertension.""?",False, +23006394,Ethanol predisposes constipation disorder,4456,"The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.","Is the triple ""Ethanol predisposes constipation disorder"" supported by the sentence: ""The risk of FC was significantly lower among subjects who drank alcohol more than 5 days a week, exercised for more than 30 min at least twice a week for more than 1 year, and were getting enough rest by sleeping, whereas it was significantly higher among women and subjects who were eating faster than other people.""?",False, +21458894,Ethanol predisposes burn,4457,The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.,"Is the triple ""Ethanol predisposes burn"" supported by the sentence: ""The combined presence of both alcohol and drugs may predispose towards more severe burns and greatly compromise liver function with heightened risk for sepsis and death.""?",False, +21015200,Ethanol predisposes benign prostatic hyperplasia,4458,The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.,"Is the triple ""Ethanol predisposes benign prostatic hyperplasia"" supported by the sentence: ""The results indicated that alcohol could significantly promote the prostate hyperplasia induced by testosterone propionate in mice.""?",False, +20014749,Ethanol predisposes neuroblastoma,4459,"STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.","Is the triple ""Ethanol predisposes neuroblastoma"" supported by the sentence: ""STUDY SELECTION: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child.""?",False, +19550164,Ethanol predisposes endometriosis,4460,"Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.","Is the triple ""Ethanol predisposes endometriosis"" supported by the sentence: ""Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol.""?",False, +15239058,Ethanol predisposes cannabis dependence,4461,"Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.","Is the triple ""Ethanol predisposes cannabis dependence"" supported by the sentence: ""Expectancies for hostility under alcohol or heroin were generally uncorrelated with other measures of personality, psychopathology, antisocial personality, impulsiveness, or criminality; but expectancies for hostility under alcohol were predictive of diagnoses of alcohol, opioid, and marijuana abuse and dependence over and above the influence of these other measures.""?",False, +13742110,Ethanol predisposes cirrhosis of liver,4462,"It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.","Is the triple ""Ethanol predisposes cirrhosis of liver"" supported by the sentence: ""It had been observed by others that subjects with endogenous familial hypertriglyceridemia (type IV hyperlipoproteinemia) showed an exaggerated lipidemic response to ingestion of alcohol, and, therefore, might be predisposed to hepatic cirrhosis.""?",False, +13158317,Ethanol predisposes erectile dysfunction,4463,"Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.","Is the triple ""Ethanol predisposes erectile dysfunction"" supported by the sentence: ""Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal.""?",False, +11801709,Ethanol predisposes type 2 diabetes mellitus,4464,No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.,"Is the triple ""Ethanol predisposes type 2 diabetes mellitus"" supported by the sentence: ""No protective effect of high alcohol consumption was seen and one cannot rule out that large intakes of alcohol may increase the risk of type 2 diabetes.""?",False, +11652545,Ethanol predisposes obesity disorder,4465,Alcohol could contribute to obesity.,"Is the triple ""Ethanol predisposes obesity disorder"" supported by the sentence: ""Alcohol could contribute to obesity.""?",False, +11461204,Ethanol predisposes atrial fibrillation,4466,"In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.","Is the triple ""Ethanol predisposes atrial fibrillation"" supported by the sentence: ""In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.""?",False, +9864711,Ethanol predisposes major depressive disorder,4467,"Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.","Is the triple ""Ethanol predisposes major depressive disorder"" supported by the sentence: ""Earlier alcohol use significantly predicted later major depressive disorder, alcohol dependence, and substance use disorders in the late 20s, as did early marijuana use and other illicit drug use.""?",False, +9226083,Ethanol predisposes alcohol abuse,4468,BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.,"Is the triple ""Ethanol predisposes alcohol abuse"" supported by the sentence: ""BACKGROUND: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations.""?",False, +8895200,Ethanol predisposes hypertensive disorder,4469,The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.,"Is the triple ""Ethanol predisposes hypertensive disorder"" supported by the sentence: ""The consumption of alcohol in amounts >/=210 g per week is an independent risk factor for hypertension in free-living North American populations.""?",False, +22402878,Sodium Hypochlorite related to Infection,4470,Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.,"Is the triple ""Sodium Hypochlorite related to Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.""?",False, +22402879,Sodium Hypochlorite prevents Infection,4471,"Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.","Is the triple ""Sodium Hypochlorite prevents Infection"" supported by the sentence: ""Near-infrared NIR irradiation and sodium hypochlorite: An efficacious association to counteract the Enterococcus faecalis biofilm in endodontic infections.New strategies are necessary for the prevention of endodontic infections caused by Enterococcus faecalis, a common resistant pathogen and biofilm producer.""?",False, +22325598,Sodium Hypochlorite prevents Pain,4472,"Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.","Is the triple ""Sodium Hypochlorite prevents Pain"" supported by the sentence: ""Sodium Hypochlorite Reduces Postoperative Discomfort and Painful Early Failure after Carious Exposure and Direct Pulp Capping-Initial Findings of a Randomized Controlled Trial.In this randomized controlled single-center clinical trial on 96 adult patients with parallel experimental groups ( n = 48), the effects of washing a dentin/pulp wound in non-symptomatic teeth with extremely deep caries and pulpal exposure were compared between a 2.5% sodium hypochlorite (NaOCl) solution and a chemically-inert physiological saline control solution.""?",False, +23522159,Hydrogen Peroxide related to gingivitis,4473,"Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.","Is the triple ""Hydrogen Peroxide related to gingivitis"" supported by the sentence: ""Conversely, the group using 1% H2O2 showed a marginal reduction in gingivitis incidence of 15% and a 28% reduction in bleeding sites compared to the placebo group, but no significant reduction in plaque scores.""?",False, +10185817,Hydrogen Peroxide related to acne,4474,STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.,"Is the triple ""Hydrogen Peroxide related to acne"" supported by the sentence: ""STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.""?",False, +9091124,Hydrogen Peroxide related to injury,4475,Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.,"Is the triple ""Hydrogen Peroxide related to injury"" supported by the sentence: ""Measurement of expired breath NO2/NO3 and H2O2 levels may be clinically useful in the management of oxidation and inflammation mediated lung injury.""?",False, +21979927,Hydrogen Peroxide causes seborrheic keratosis,4476,Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.,"Is the triple ""Hydrogen Peroxide causes seborrheic keratosis"" supported by the sentence: ""Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid.""?",False, +7121153,Hydrogen Peroxide causes injury,4477,Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.,"Is the triple ""Hydrogen Peroxide causes injury"" supported by the sentence: ""Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury.""?",False, +18988282,Hydrogen Peroxide affects severe acute respiratory syndrome,4478,"Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.","Is the triple ""Hydrogen Peroxide affects severe acute respiratory syndrome"" supported by the sentence: ""Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII.""?",False, +15261236,Hydrogen Peroxide affects gingivitis,4479,"Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.","Is the triple ""Hydrogen Peroxide affects gingivitis"" supported by the sentence: ""Hydrogen peroxide, the effect on plaque and gingivitis when used in an oral irrigator.""?",False, +9489971,Hydrogen Peroxide affects injury,4480,Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats.""?",False, +7188934,Hydrogen Peroxide affects injury,4481,These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.,"Is the triple ""Hydrogen Peroxide affects injury"" supported by the sentence: ""These results show one strategy of protecting renal cells from H2O2-mediated injury based on increasing their antioxidant defenses.""?",False, +20490056,Hydrogen Peroxide disrupts dental caries,4482,"Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.","Is the triple ""Hydrogen Peroxide disrupts dental caries"" supported by the sentence: ""Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease.""?",False, +17081431,Hydrogen Peroxide disrupts injury,4483,Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.,"Is the triple ""Hydrogen Peroxide disrupts injury"" supported by the sentence: ""Physiological measurements indicated that transgenic tobacco seedlings retained high K(+)/Na(+) ratios and Ca(2+) content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress.""?",False, +8804977,Hydrogen Peroxide disrupts gingivitis,4484,CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.,"Is the triple ""Hydrogen Peroxide disrupts gingivitis"" supported by the sentence: ""CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.""?",False, +21124110,Hydrogen Peroxide prevents acne,4485,"Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.","Is the triple ""Hydrogen Peroxide prevents acne"" supported by the sentence: ""Hydrogen peroxide skin preparation reduces Cutibacterium acnes in shoulder arthroplasty: a prospective, blinded, controlled trial.""?",False, +11091070,Hydrogen Peroxide prevents gingivitis,4486,CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.,"Is the triple ""Hydrogen Peroxide prevents gingivitis"" supported by the sentence: ""CONCLUSION: The results of this study indicate that the fluoridated hydrogen peroxide-based mouthrinse effectively whitens teeth and significantly reduces gingivitis.""?",False, +7482647,Hydrogen Peroxide prevents injury,4487,"Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.","Is the triple ""Hydrogen Peroxide prevents injury"" supported by the sentence: ""Treatment with a range of herbicides used to control grass weeds in wheat resulted in increased levels of hydroperoxides in herbicide-susceptible populations but not in herbicide-resistant plants, consistent with AmGST2 functioning to prevent oxidative injury caused as a primary or secondary effect of herbicide action.""?",False, +19925807,Hydrogen Peroxide predisposes dental caries,4488,"Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.","Is the triple ""Hydrogen Peroxide predisposes dental caries"" supported by the sentence: ""Our laboratory showed previously that, under aerobic conditions, S. sanguinis can produce H2O2 to inhibit the growth of bacterial species that promote dental caries.""?",False, +10852631,Hydrogen Peroxide predisposes injury,4489,Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.,"Is the triple ""Hydrogen Peroxide predisposes injury"" supported by the sentence: ""Reduced ability to remove hydrogen peroxide appears to be an important determinant of myocyte injury during reoxygenation.""?",False, +23181733,Vitamin K1 related to Hemorrhage,4490,"Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).","Is the triple ""Vitamin K1 related to Hemorrhage"" supported by the sentence: ""Lower bleeding incidence was observed among patients administered vitamin K 1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).""?",False, +20221966,Vitamin K1 related to postmenopausal osteoporosis,4491,Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.,"Is the triple ""Vitamin K1 related to postmenopausal osteoporosis"" supported by the sentence: ""Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.""?",False, +19764095,Vitamin K1 related to osteoporosis,4492,Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.,"Is the triple ""Vitamin K1 related to osteoporosis"" supported by the sentence: ""Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease.""?",False, +17682094,Vitamin K1 related to atrial fibrillation,4493,We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.,"Is the triple ""Vitamin K1 related to atrial fibrillation"" supported by the sentence: ""We report a case of a fatal massive anterior acute myocardial infarction (AMI) after administration of vitamin K1 for over-anticoagulation following cardioembolism from mechanical mitroaortic valve prostheses associated with atrial fibrillation.""?",False, +13777524,Vitamin K1 related to cystic fibrosis,4494,Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.,"Is the triple ""Vitamin K1 related to cystic fibrosis"" supported by the sentence: ""Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis.""?",False, +11304774,Vitamin K1 affects Hemorrhage,4495,"RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.","Is the triple ""Vitamin K1 affects Hemorrhage"" supported by the sentence: ""RESULTS: The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions.""?",False, +24408540,Vitamin K1 prevents Hemorrhage,4496,OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.,"Is the triple ""Vitamin K1 prevents Hemorrhage"" supported by the sentence: ""OBJECTIVES: This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.""?",False, +13476259,Vitamin K1 prevents vitamin K deficiency hemorrhagic disease,4497,OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.,"Is the triple ""Vitamin K1 prevents vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""OBJECTIVE: To compare efficacy of intramuscular phytomenadione (fat soluble vitamin K or vitamin K1) with menadione (water soluble vitamin K or vitamin K3) in prevention of subclinical vitamin K deficiency.""?",False, +10772424,Vitamin K1 predisposes postmenopausal osteoporosis,4498,"If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.","Is the triple ""Vitamin K1 predisposes postmenopausal osteoporosis"" supported by the sentence: ""If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.""?",False, +9319754,Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease,4499,"Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.","Is the triple ""Vitamin K1 predisposes vitamin K deficiency hemorrhagic disease"" supported by the sentence: ""Other than plasma vitamin K1 concentrations, PIVKA (undercarboxylated prothrombin produced in the absence of vitamin K) is a marker of vitamin K deficiency.""?",False, +24430542,Indapamide causes type 2 diabetes mellitus,4500,The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).,"Is the triple ""Indapamide causes type 2 diabetes mellitus"" supported by the sentence: ""The current study aimed to evaluate the anti-diabetic effects of canagliflozin (CANA) and indapamide (INDA) and their impacts as adiponectin modulators in experimentally induced type 2 diabetes mellitus (T2DM).""?",False, +24430545,Indapamide affects type 2 diabetes mellitus,4501,"INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.","Is the triple ""Indapamide affects type 2 diabetes mellitus"" supported by the sentence: ""INDA could be effective in regulating T2DM, with underlined anti-diabetic, antioxidant, and anti-inflammatory properties.""?",False, +10214767,Indapamide affects hypertensive disorder,4502,This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.,"Is the triple ""Indapamide affects hypertensive disorder"" supported by the sentence: ""This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.""?",False, +13327254,Indapamide prevents hypertensive disorder,4503,During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.,"Is the triple ""Indapamide prevents hypertensive disorder"" supported by the sentence: ""During the chronic treatment additive and synergic effects of indapamide and captopril may contribute to the prevention of hypertension and increase of vasorelaxation.""?",False, +18173402,Perphenazine related to schizophrenia,4504,Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.,"Is the triple ""Perphenazine related to schizophrenia"" supported by the sentence: ""Intraindividual comparison of the effect of perphenazine and of the combination of perphenazine and lithium in schizophrenia.""?",False, +11307427,Perphenazine related to Postoperative Nausea and Vomiting,4505,"CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.","Is the triple ""Perphenazine related to Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSIONS: For ACL reconstruction with regional anesthesia, use of LUM-SCI was associated with a higher rate of PONV, whereas combination antiemetic prophylaxis with perphenazine and dexamethasone was associated with less PONV.""?",False, +19924977,Perphenazine disrupts cocaine dependence,4506,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts cocaine dependence"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, +19924976,Perphenazine disrupts schizophrenia,4507,"Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.","Is the triple ""Perphenazine disrupts schizophrenia"" supported by the sentence: ""Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence.""?",False, +15171439,Perphenazine prevents Postoperative Nausea and Vomiting,4508,CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.,"Is the triple ""Perphenazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""CONCLUSION: there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo.""?",False, +27208453,Perphenazine exacerbates dementia,4509,We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.,"Is the triple ""Perphenazine exacerbates dementia"" supported by the sentence: ""We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia.""?",False, +26847530,Fluphenazine affects psychotic disorder,4510,BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.,"Is the triple ""Fluphenazine affects psychotic disorder"" supported by the sentence: ""BACKGROUND: We studied the effectiveness of treating patients with low doses of fluphenazine decanoate and supplementing them with oral fluphenazine when there was evidence of prodromal symptoms of psychotic exacerbations.""?",False, +11127872,Fluphenazine prevents psychotic disorder,4511,"Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.","Is the triple ""Fluphenazine prevents psychotic disorder"" supported by the sentence: ""Olanzapine was better than fluphenazine in reducing most of the psychotic and PTSD symptoms, and was better tolerated in psychotic PTSD patients.""?",False, +10396371,Prochlorperazine disrupts Nausea,4512,"A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.","Is the triple ""Prochlorperazine disrupts Nausea"" supported by the sentence: ""A combination of lorazepam, prochlorperazine, dexamethasone, scopolamine and ondansetron was used to prevent and diminish the occurrence of nausea and vomiting during administration of emetogenic chemotherapy.""?",False, +11808182,Prochlorperazine prevents Postoperative Nausea and Vomiting,4513,"OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.","Is the triple ""Prochlorperazine prevents Postoperative Nausea and Vomiting"" supported by the sentence: ""OBJECTIVE: To compare the cost-effectiveness of 2 antiemetic agents, ondansetron and prochlorperazine, for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing total hip replacement or total knee replacement procedures.""?",False, +10634177,Prochlorperazine prevents migraine disorder,4514,Prevention of migraine in children by prochlorperazine.,"Is the triple ""Prochlorperazine prevents migraine disorder"" supported by the sentence: ""Prevention of migraine in children by prochlorperazine.""?",False, +7427448,Prochlorperazine prevents Nausea,4515,Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.,"Is the triple ""Prochlorperazine prevents Nausea"" supported by the sentence: ""Cost-effectiveness analysis of oral ondansetron and prochlorperazine for preventing nausea and vomiting after moderately emetogenic chemotherapy.""?",False, +11272109,ELOSULFASE ALFA related to mucopolysaccharidosis type 4,4516,N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.,"Is the triple ""ELOSULFASE ALFA related to mucopolysaccharidosis type 4"" supported by the sentence: ""N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.""?",False, +26291786,ELOSULFASE ALFA derives from Keratan,4517,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, +26291786,ELOSULFASE ALFA derives from Keratan,4518,"There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.","Is the triple ""ELOSULFASE ALFA derives from Keratan"" supported by the sentence: ""There were iduronate sulfatase, arylsulfatase B, heparan sulfate (HS) sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, HS-derived N-acetylglucosamine-6-sulfate sulfatase, and two keratan sulfate (KS)-derived N-acetylglucosamine-6-sulfate sulfatases.""?",False, +16241796,ELOSULFASE ALFA physically interacts with Keratan,4519,"The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA physically interacts with Keratan"" supported by the sentence: ""The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, +16652816,ELOSULFASE ALFA causes mucopolysaccharidosis type 4,4520,PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.,"Is the triple ""ELOSULFASE ALFA causes mucopolysaccharidosis type 4"" supported by the sentence: ""PURPOSE: Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.""?",False, +13130107,ELOSULFASE ALFA affects Keratan,4521,"Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.","Is the triple ""ELOSULFASE ALFA affects Keratan"" supported by the sentence: ""Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.""?",False, +21593588,Pegvaliase related to phenylketonuria,4522,Case-control study about the acceptance of Pegvaliase in Phenylketonuria.,"Is the triple ""Pegvaliase related to phenylketonuria"" supported by the sentence: ""Case-control study about the acceptance of Pegvaliase in Phenylketonuria.""?",False, +23111774,Labetalol related to preeclampsia,4523,"To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.","Is the triple ""Labetalol related to preeclampsia"" supported by the sentence: ""To date methyldopa, labetalol, nifedipine and metoprolol are recommended for controlling blood pressure in pre-eclampsia.""?",False, +19865755,Labetalol related to hypertensive disorder,4524,"Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.","Is the triple ""Labetalol related to hypertensive disorder"" supported by the sentence: ""Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication.""?",False, +19886747,Labetalol causes hypertensive disorder,4525,Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.,"Is the triple ""Labetalol causes hypertensive disorder"" supported by the sentence: ""Response & Side Effects of Injectable Labetalol in Pregnancy Induced Severe Hypertension.""?",False, +7968423,Labetalol causes hypotensive disorder,4526,"For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.","Is the triple ""Labetalol causes hypotensive disorder"" supported by the sentence: ""For severe 'late-onset' pregnancy hypertension (n=5 trials), i.v. labetalol produced less maternal hypotension (OR 0.13 [0.03, 0.71]) and fewer cesareans (OR 0.23 [0.13, 0.63]) than i.v.""?",False, +26371124,Labetalol affects hypertensive disorder,4527,The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy.""?",False, +16245918,Labetalol affects stroke disorder,4528,"BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.","Is the triple ""Labetalol affects stroke disorder"" supported by the sentence: ""BACKGROUND: American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents.""?",False, +15472186,Labetalol affects hypertensive disorder,4529,The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.,"Is the triple ""Labetalol affects hypertensive disorder"" supported by the sentence: ""The mechanism of action of IV labetalol in controlling hypertension after CABG surgery seems to be moderate negative inotropy and chronotropy.""?",False, +11424839,Labetalol affects hypotensive disorder,4530,The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.,"Is the triple ""Labetalol affects hypotensive disorder"" supported by the sentence: ""The effect of labetalol on deliberate hypotension was studied in 24 adult patients undergoing middle-ear surgery.""?",False, +24194004,Labetalol prevents preeclampsia,4531,"CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.","Is the triple ""Labetalol prevents preeclampsia"" supported by the sentence: ""CONCLUSIONS: In summary, all commonly prescribed antihypertensives in pregnancy reduce the risk of severe hypertension, but labetalol may also decrease proteinuria/preeclampsia and fetal/newborn death.""?",False, +16282554,Labetalol prevents hypertensive disorder,4532,"Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.","Is the triple ""Labetalol prevents hypertensive disorder"" supported by the sentence: ""Labetalol appears to be an effective and safe agent to use in decreasing hypertension, tachycardia, and possibly arrhythmias in high-risk medical patients with cardiovascular disease undergoing ECT.""?",False, +16892434,Labetalol predisposes stroke disorder,4533,"Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.","Is the triple ""Labetalol predisposes stroke disorder"" supported by the sentence: ""Intraoperative metoprolol but not esmolol or labetalol, is associated with increased risk of perioperative stroke.""?",False, +15232781,Carvedilol related to hypertensive disorder,4534,Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.,"Is the triple ""Carvedilol related to hypertensive disorder"" supported by the sentence: ""Effect of combining extended-release carvedilol and lisinopril in hypertension: results of the COSMOS study.""?",False, +15407113,Carvedilol causes Left ventricular hypertrophy,4535,Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.,"Is the triple ""Carvedilol causes Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol treatment resulted in less left ventricular hypertrophy and dilatation.""?",False, +14049404,Carvedilol causes epilepsy,4536,Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.,"Is the triple ""Carvedilol causes epilepsy"" supported by the sentence: ""Effect of carvedilol on seizure induction during electroconvulsive therapy procedure.""?",False, +19046224,Carvedilol affects esophageal varices,4537,Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.,"Is the triple ""Carvedilol affects esophageal varices"" supported by the sentence: ""Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.""?",False, +17542363,Carvedilol affects Left ventricular hypertrophy,4538,"Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Comparison of effects of nebivolol, carvedilol and irbesartan on left ventricular hypertrophy associated with hypertension.""?",False, +11530189,Carvedilol affects essential hypertension,4539,Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.,"Is the triple ""Carvedilol affects essential hypertension"" supported by the sentence: ""Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.""?",False, +11200172,Carvedilol affects atrial fibrillation,4540,Role of carvedilol in atrial fibrillation: insights from clinical trials.,"Is the triple ""Carvedilol affects atrial fibrillation"" supported by the sentence: ""Role of carvedilol in atrial fibrillation: insights from clinical trials.""?",False, +10614289,Carvedilol affects Stable angina,4541,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects Stable angina"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, +10614288,Carvedilol affects hypertensive disorder,4542,"Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""Carvedilol is a nonselective beta-blocker with alpha-mediated vasodilating properties that has been shown to be effective in systemic hypertension, stable angina, and congestive heart failure (CHF).""?",False, +10402879,Carvedilol affects hypertensive disorder,4543,"In addition, carvedilol reduced elevated blood pressure in allografted rats.","Is the triple ""Carvedilol affects hypertensive disorder"" supported by the sentence: ""In addition, carvedilol reduced elevated blood pressure in allografted rats.""?",False, +9269217,Carvedilol affects Left ventricular hypertrophy,4544,"Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.","Is the triple ""Carvedilol affects Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation.""?",False, +9116913,Carvedilol affects cardiovascular disorder,4545,All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.,"Is the triple ""Carvedilol affects cardiovascular disorder"" supported by the sentence: ""All these findings may play an important role in the beneficial effects of carvedilol treatment in different cardiovascular diseases.""?",False, +7256243,Carvedilol affects portal hypertension,4546,BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.,"Is the triple ""Carvedilol affects portal hypertension"" supported by the sentence: ""BACKGROUND/AIMS: Recent reports have suggested that the vasodilating beta-blocker carvedilol may have beneficial acute haemodynamic effects in cirrhotic portal hypertension.""?",False, +24587957,Carvedilol disrupts portal hypertension,4547,"Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.","Is the triple ""Carvedilol disrupts portal hypertension"" supported by the sentence: ""Herein, using a competing-risk meta-analysis to optimize sample size and properly investigate cirrhosis as a multistate disease and outcomes as time-dependent events, we show that carvedilol (a non-selective beta-blocker) is associated with a reduced risk of decompensating events and improved survival in patients with cirrhosis and portal hypertension.""?",False, +21108262,Carvedilol disrupts myocardial infarction,4548,"The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.","Is the triple ""Carvedilol disrupts myocardial infarction"" supported by the sentence: ""The protective effect of carvedilol was further supported in an in vivo regional ischemia model by ligation of left anterior descending coronary artery (LAD), mice treated with carvedilol followed by LAD occlusion and reperfusion showed significant size reduction in infarcted myocardium and improved cardiac functions.""?",False, +13210472,Carvedilol disrupts atrial fibrillation,4549,"The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.","Is the triple ""Carvedilol disrupts atrial fibrillation"" supported by the sentence: ""The efficacy of existing drugs, such as carvedilol, for rate control and, possibly, suppression of AF, is more appreciated.""?",False, +23631897,Carvedilol prevents neoplasm,4550,Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.,"Is the triple ""Carvedilol prevents neoplasm"" supported by the sentence: ""Results: ZZAE (100 and 200 mg/kg) and carvedilol decreased tumor incidence compared to that of control.""?",False, +23413400,Carvedilol prevents myocardial infarction,4551,Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.,"Is the triple ""Carvedilol prevents myocardial infarction"" supported by the sentence: ""Rosuvastatin and low dose carvedilol combination protects against isoprenaline- induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signaling.""?",False, +20796578,Carvedilol prevents hypoglycemia,4552,"To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.","Is the triple ""Carvedilol prevents hypoglycemia"" supported by the sentence: ""To assess whether carvedilol prevented IAH, we treated rats that had received repeated 2-deoxyglucose (2DG) injections to impair their awareness of hypoglycaemia with carvedilol and measured food intake in response to insulin-induced hypoglycaemia as a surrogate marker for hypoglycaemia awareness.""?",False, +17416516,Carvedilol prevents portal hypertension,4553,CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.,"Is the triple ""Carvedilol prevents portal hypertension"" supported by the sentence: ""CONCLUSIONS: Carvedilol reduces portal hypertension significantly more than propranolol.""?",False, +15996194,Carvedilol prevents hypertensive disorder,4554,Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.,"Is the triple ""Carvedilol prevents hypertensive disorder"" supported by the sentence: ""Pilot study data show that carvedilol reduces the frequency of intradialytic hypertension and improves endothelial cell dysfunction.""?",False, +15794060,Carvedilol prevents Abnormal left ventricular function,4555,Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.,"Is the triple ""Carvedilol prevents Abnormal left ventricular function"" supported by the sentence: ""Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial.""?",False, +15707001,Carvedilol prevents kidney disorder,4556,"Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.","Is the triple ""Carvedilol prevents kidney disorder"" supported by the sentence: ""Moreover, carvedilol was also effective in reducing BP levels in elderly patients (>=65 years) and in patients with diabetes mellitus or renal diseases.""?",False, +12564717,Carvedilol prevents atrial fibrillation,4557,Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).,"Is the triple ""Carvedilol prevents atrial fibrillation"" supported by the sentence: ""Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).""?",False, +8686828,Carvedilol prevents Left ventricular hypertrophy,4558,Carvedilol reduced LVH by 20%.,"Is the triple ""Carvedilol prevents Left ventricular hypertrophy"" supported by the sentence: ""Carvedilol reduced LVH by 20%.""?",False, +23747042,Carvedilol predisposes type 2 diabetes mellitus,4559,"However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.","Is the triple ""Carvedilol predisposes type 2 diabetes mellitus"" supported by the sentence: ""However, carvedilol was associated with lowered risk of new-onset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol.""?",False, +22663350,Carvedilol predisposes atrial fibrillation,4560,"However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).","Is the triple ""Carvedilol predisposes atrial fibrillation"" supported by the sentence: ""However, metoprolol increased the risk of POAF compared with carvedilol (159 patients; RR 1.59, 95% CI 1.20 to 2.12; I2=4%; RD 0.13, 95% CI 0.06 to 0.20).""?",False, +21640789,Carvedilol predisposes hypoglycemia,4561,"This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.","Is the triple ""Carvedilol predisposes hypoglycemia"" supported by the sentence: ""This study compared the survival and the risk of heart failure (HF), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypoglycemia, and renal failure (RF) hospitalizations in geriatric patients exposed to carvedilol or metoprolol.""?",False, +21331523,Carvedilol predisposes myocardial infarction,4562,The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).,"Is the triple ""Carvedilol predisposes myocardial infarction"" supported by the sentence: ""The use of carvedilol was also determined to be an independent predictor for recurrent myocardial infarctions (hazard ratio = 0.305; p = 0.005; 95% confidence interval = 0.13-0.69).""?",False, +20291576,Raloxifene related to schizophrenia,4563,A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.,"Is the triple ""Raloxifene related to schizophrenia"" supported by the sentence: ""A replication of positive findings by at least two clinical trials was found for mifepristone in BD and raloxifene and pregnenolone in schizophrenia.""?",False, +13558027,Raloxifene related to postmenopausal osteoporosis,4564,Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.,"Is the triple ""Raloxifene related to postmenopausal osteoporosis"" supported by the sentence: ""Efficacy of combined treatment with raloxifene and alfacalcidol on bone density and biochemical markers of bone turnover in postmenopausal osteoporosis.""?",False, +27583128,Raloxifene causes breast neoplasm,4565,Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.,"Is the triple ""Raloxifene causes breast neoplasm"" supported by the sentence: ""Raloxifene inhibits estrogen-dependent proliferation of human breast cancer cells in vitro and development of induced mammary tumours in rats in vivo.""?",False, +20242808,Raloxifene affects psychotic disorder,4566,"In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.","Is the triple ""Raloxifene affects psychotic disorder"" supported by the sentence: ""In contrast, 17alpha-estradiol and raloxifene showed little effect on dopamine receptor-mediated psychosis-like behaviours.""?",False, +16098538,Raloxifene affects schizophrenia,4567,Beneficial effects of add-on raloxifene in schizophrenia.,"Is the triple ""Raloxifene affects schizophrenia"" supported by the sentence: ""Beneficial effects of add-on raloxifene in schizophrenia.""?",False, +15267794,Raloxifene affects Marchiafava-Bignami disease,4568,"To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.","Is the triple ""Raloxifene affects Marchiafava-Bignami disease"" supported by the sentence: ""To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice.""?",False, +11233936,Raloxifene affects breast neoplasm,4569,"OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.","Is the triple ""Raloxifene affects breast neoplasm"" supported by the sentence: ""OBJECTIVE: The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.""?",False, +10869334,Raloxifene affects osteoporosis,4570,"While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.","Is the triple ""Raloxifene affects osteoporosis"" supported by the sentence: ""While estrogen plays a role in osteoporosis, the bisphosphonates and raloxifene demonstrate equal or superior efficacy for prevention and treatment, compared with HRT.""?",False, +9569313,Raloxifene affects postmenopausal osteoporosis,4571,"Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.","Is the triple ""Raloxifene affects postmenopausal osteoporosis"" supported by the sentence: ""Recent information on the effects of raloxifene in postmenopausal osteoporosis, breast cancer prevention and cardiovascular disease in high-risk women and those with uterine disorders is reviewed in this article.""?",False, +15267792,Raloxifene disrupts Marchiafava-Bignami disease,4572,Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.,"Is the triple ""Raloxifene disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanism.""?",False, +13369623,Raloxifene disrupts osteoporosis,4573,Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.,"Is the triple ""Raloxifene disrupts osteoporosis"" supported by the sentence: ""Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis.""?",False, +7874352,Raloxifene disrupts postmenopausal osteoporosis,4574,The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.,"Is the triple ""Raloxifene disrupts postmenopausal osteoporosis"" supported by the sentence: ""The selective estrogen receptor modulator (SERM) raloxifene also slows postmenopausal bone loss although it is less effective that HRT.""?",False, +16984197,Raloxifene prevents Alzheimer disease,4575,"We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.","Is the triple ""Raloxifene prevents Alzheimer disease"" supported by the sentence: ""We found that 60 mg/day raloxifene could improve verbal memory, and 120 mg/day raloxifene produced a 33% decrease in the risk of mild cognitive impairment and also lowered the risk of Alzheimer's disease.""?",False, +12036378,Raloxifene prevents breast neoplasm,4576,"We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.","Is the triple ""Raloxifene prevents breast neoplasm"" supported by the sentence: ""We first assessed the ability of ospemifene, compared to tamoxifen and raloxifene, to prevent dimethylbenzanthracene (DMBA)-induced mammary tumors in female Sencar mice.""?",False, +7813032,Raloxifene prevents postmenopausal osteoporosis,4577,Raloxifene to prevent postmenopausal osteoporosis.,"Is the triple ""Raloxifene prevents postmenopausal osteoporosis"" supported by the sentence: ""Raloxifene to prevent postmenopausal osteoporosis.""?",False, +7578651,Raloxifene prevents osteoporosis,4578,"Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.","Is the triple ""Raloxifene prevents osteoporosis"" supported by the sentence: ""Among this class of compounds, raloxifene is the most studied and is currently available for clinical use in some countries for the prevention of osteoporosis in post-menopausal women.""?",False, +7570810,Raloxifene prevents Marchiafava-Bignami disease,4579,RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.,"Is the triple ""Raloxifene prevents Marchiafava-Bignami disease"" supported by the sentence: ""RAL prevents bone loss and reduces serum cholesterol in postmenopausal women.""?",False, +11746046,Raloxifene predisposes Alzheimer disease,4580,"OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.","Is the triple ""Raloxifene predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease.""?",False, +11350173,Raloxifene predisposes osteoporosis,4581,"Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.","Is the triple ""Raloxifene predisposes osteoporosis"" supported by the sentence: ""Raloxifene, a selective estrogen receptor modulator (SERM) licensed for the prevention of non-traumatic vertebral fractures in postmenopausal women at increased risk of osteoporosis, was launched in the UK in August 1998.""?",False, +23481448,Bazedoxifene acetate prevents osteoporosis,4582,"These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.","Is the triple ""Bazedoxifene acetate prevents osteoporosis"" supported by the sentence: ""These include tamoxifen, used as adjuvant therapy in breast cancer patients as well as for breast cancer prevention; raloxifene, approved for osteoporosis prevention and treatment as well as breast cancer prevention; bazedoxifene, approved for prevention of osteoporosis and also in combination with conjugated equine estrogen for treatment of vasomotor symptoms and prevention of bone loss in postmenopausal patients; and ospemifene, approved for treatment of dyspareunia due to vulvovaginal atrophy/genitourinary syndrome of menopause.""?",False, +19905553,Ospemifene disrupts psychologic dyspareunia,4583,"In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.","Is the triple ""Ospemifene disrupts psychologic dyspareunia"" supported by the sentence: ""In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia.""?",False, +15516940,Sufentanil affects Pain,4584,The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.,"Is the triple ""Sufentanil affects Pain"" supported by the sentence: ""The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol.""?",False, +20743116,Sufentanil prevents delirium,4585,"CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.","Is the triple ""Sufentanil prevents delirium"" supported by the sentence: ""CONCLUSIONS DEX and sufentanil decrease the incidence of POD, ameliorate the abnormities of hemodynamic indicators, and decrease VAS scores, SAS scores, stress hormones, and inflammatory biomarkers, but increase the incidence of respiratory distress.""?",False, +8151024,Sufentanil prevents Pain,4586,Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.,"Is the triple ""Sufentanil prevents Pain"" supported by the sentence: ""Sedation with sufentanil and midazolam decreases pain in patients undergoing upper limb surgery under multiple nerve block.""?",False, +12819365,Streptomycin related to Buruli ulcer disease,4587,The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.,"Is the triple ""Streptomycin related to Buruli ulcer disease"" supported by the sentence: ""The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments.""?",False, +11425591,Streptomycin related to osteomyelitis,4588,Streptomycin in chronic traumatic osteomyelitis.,"Is the triple ""Streptomycin related to osteomyelitis"" supported by the sentence: ""Streptomycin in chronic traumatic osteomyelitis.""?",False, +10417352,Streptomycin related to plague,4589,Role of streptomycin in plague.,"Is the triple ""Streptomycin related to plague"" supported by the sentence: ""Role of streptomycin in plague.""?",False, +10748245,Streptomycin causes plague,4590,[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].,"Is the triple ""Streptomycin causes plague"" supported by the sentence: ""[Therapeutic activity of chlortetracycline in experimental plague caused by streptomycin resistant and sensitive strains of Pasteurella pestis].""?",False, +26655494,Streptomycin prevents mycobacterium avium complex disease,4591,"Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.","Is the triple ""Streptomycin prevents mycobacterium avium complex disease"" supported by the sentence: ""Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.""?",False, +14226518,Paromomycin related to cutaneous leishmaniasis,4592,"In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).","Is the triple ""Paromomycin related to cutaneous leishmaniasis"" supported by the sentence: ""In SbV-controlled trials, the efficacy of topical PR was not significantly different from that of intralesional SbV in the old world CL (RR, 0.70; 95% confidence interval, 0.26-1.89), whereas topical PR was inferior to parenteral SbV in treating the new world CL (0.67; 0.54-0.82).""?",False, +12550860,Paromomycin related to visceral leishmaniasis,4593,"Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.","Is the triple ""Paromomycin related to visceral leishmaniasis"" supported by the sentence: ""Studies using paromomycin in VL are encouraging, and judging by the preliminary results of a recently concluded phase III trial, it could be an extremely useful and affordable antileishmanial drug.""?",False, +24692385,Paromomycin affects leishmaniasis,4594,"Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.","Is the triple ""Paromomycin affects leishmaniasis"" supported by the sentence: ""Our findings confirm that the municipality of Embu das Artes is endemic for canine leishmaniasis and that isolates from this region are susceptible to paromomycin and miltefosine, indicating the potential of these drugs to be clinically evaluated in the treatment of human visceral leishmaniasis in Brazil.""?",False, +23700620,Paromomycin affects visceral leishmaniasis,4595,The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.,"Is the triple ""Paromomycin affects visceral leishmaniasis"" supported by the sentence: ""The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.""?",False, +22567030,Paromomycin affects cutaneous leishmaniasis,4596,"Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.","Is the triple ""Paromomycin affects cutaneous leishmaniasis"" supported by the sentence: ""Here, we evaluated paromomycin susceptibility in vitro of a L. amazonensis clinical isolate from a patient with cutaneous leishmaniasis and the reference strain L. amazonensis M2269, as well as its in vivo efficacy in a murine experimental model.""?",False, +27729096,Kanamycin related to bacterial infectious disease,4597,The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.,"Is the triple ""Kanamycin related to bacterial infectious disease"" supported by the sentence: ""The efficacy of amikacin was comparable to that of kanamycin or gentamicin in neonatal bacterial diseases.""?",False, +10553348,Kanamycin related to tuberculosis,4598,Kanamycin in experimental guinea pig tuberculosis.,"Is the triple ""Kanamycin related to tuberculosis"" supported by the sentence: ""Kanamycin in experimental guinea pig tuberculosis.""?",False, +10567002,Kanamycin affects tuberculosis,4599,Effects of kanamycin in experimental tuberculosis of guinea pigs.,"Is the triple ""Kanamycin affects tuberculosis"" supported by the sentence: ""Effects of kanamycin in experimental tuberculosis of guinea pigs.""?",False, +25418796,Vancomycin related to ulcerative colitis,4600,Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.,"Is the triple ""Vancomycin related to ulcerative colitis"" supported by the sentence: ""Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation.""?",False, +24528866,Vancomycin related to bacterial infectious disease,4601,"Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.","Is the triple ""Vancomycin related to bacterial infectious disease"" supported by the sentence: ""Between June 2015 and March 2016, a quasi-experimental study consisting on a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections and cystitis.""?",False, +23989025,Vancomycin related to Inflammation,4602,"The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""The elimination of bacterial counts, along with improvement of tissue inflammation and serum inflammatory markers, were observed in the rats with SV plus intra-wound VP.""?",False, +22667296,Vancomycin related to arthropathy,4603,"Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).","Is the triple ""Vancomycin related to arthropathy"" supported by the sentence: ""Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55).""?",False, +21740759,Vancomycin related to Infection,4604,"Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""Therapeutic Drug Monitoring Coupled with Bayesian Forecasting could Prevent Vancomycin-associated Nephrotoxicity in Renal Insufficiency Patients: A Prospective Study and Pharmacoeconomic Analysis.BACKGROUND: Vancomycin is a critical antibiotic used in important infections, and therapeutic drug monitoring is recommended.""?",False, +20543239,Vancomycin related to hematopoietic and lymphoid system neoplasm,4605,"Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.","Is the triple ""Vancomycin related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Specific conditions of patients such as febrile neutropenia, solid tumor, and blood cancer were associated with elevated VCM clearance; however, there was no decline in trough VCM concentrations regardless of the presence of the specific conditions.""?",False, +20099844,Vancomycin related to cystic fibrosis,4606,Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.,"Is the triple ""Vancomycin related to cystic fibrosis"" supported by the sentence: ""Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus.""?",False, +18717834,Vancomycin related to eye infectious disorder,4607,"MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.","Is the triple ""Vancomycin related to eye infectious disorder"" supported by the sentence: ""MRSA with reduced susceptibility to glycopeptide antibiotics such as vancomycin (vancomycin intermediate S. aureus, VISA) have also emerged in the ocular infections, and there has been a rise in S. aureus resistance to new and old generation fluoroquinolones that are commonly used for prophylaxis after intravitreal injections and intraocular surgeries.""?",False, +18563763,Vancomycin related to staphylococcal pneumonia,4608,No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.,"Is the triple ""Vancomycin related to staphylococcal pneumonia"" supported by the sentence: ""No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period.""?",False, +17578296,Vancomycin related to Peptidoglycan,4609,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, +17578296,Vancomycin related to Peptidoglycan,4610,CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.,"Is the triple ""Vancomycin related to Peptidoglycan"" supported by the sentence: ""CS-CA inhibited RNA and PG to the same degree while RNA accumulation was clearly more sensitive to Vanco than was PG.""?",False, +15843803,Vancomycin related to Diabetic Foot,4611,"With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.","Is the triple ""Vancomycin related to Diabetic Foot"" supported by the sentence: ""With regard to infections with MRSA, classical agents like vancomycin, linezolid, fosfomycin or trimethroprim-sulphametoxazol might be agents of choice in DFU.""?",False, +15502624,Vancomycin related to abscess,4612,Vancomycin and ciprofloxacin levels were inadequate in most abscesses.,"Is the triple ""Vancomycin related to abscess"" supported by the sentence: ""Vancomycin and ciprofloxacin levels were inadequate in most abscesses.""?",False, +15448370,Vancomycin related to obesity disorder,4613,There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).,"Is the triple ""Vancomycin related to obesity disorder"" supported by the sentence: ""There was a trend toward higher vancomycin serum concentrations in obese (6.9 +/- 4.30 MUg/mL) versus nonobese children (4.8 +/- 3.08 MUg/mL; P = .052).""?",False, +15389679,Vancomycin related to osteomyelitis,4614,Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.,"Is the triple ""Vancomycin related to osteomyelitis"" supported by the sentence: ""Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis.""?",False, +15008716,Vancomycin related to peritonitis,4615,CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""CONCLUSION: Vancomycin appeared to be superior to cefazolin in the treatment of peritoneal dialysis associated peritonitis.""?",False, +14607992,Vancomycin related to pneumonia,4616,"Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.","Is the triple ""Vancomycin related to pneumonia"" supported by the sentence: ""Clinical trials have been conducted to compare vancomycin and linezolid head-to-head in pneumonia and, in post hoc subgroup analyses, showed that linezolid use was associated with improved survival.""?",False, +14564943,Vancomycin related to gram-positive bacterial infections,4617,"Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.","Is the triple ""Vancomycin related to gram-positive bacterial infections"" supported by the sentence: ""Two Phase III multicenter trials have demonstrated noninferiority in complicated skin and skin structure infections when tested against vancomycin in primarily Gram-positive bacterial infections, and when tested against vancomycin plus ceftazidime in Gram-positive and Gram-negative bacterial infections.""?",False, +11348824,Vancomycin related to kidney failure,4618,"The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.","Is the triple ""Vancomycin related to kidney failure"" supported by the sentence: ""The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.""?",False, +11195361,Vancomycin related to Neonatal sepsis,4619,"Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.","Is the triple ""Vancomycin related to Neonatal sepsis"" supported by the sentence: ""Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit.""?",False, +10946982,Vancomycin related to respiratory tract infectious disorder,4620,This may give linezolid an advantage over vancomycin in certain respiratory infections.,"Is the triple ""Vancomycin related to respiratory tract infectious disorder"" supported by the sentence: ""This may give linezolid an advantage over vancomycin in certain respiratory infections.""?",False, +10225522,Vancomycin related to bacterial infectious disease with sepsis,4621,These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.,"Is the triple ""Vancomycin related to bacterial infectious disease with sepsis"" supported by the sentence: ""These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.""?",False, +9057886,Vancomycin related to nosocomial infection,4622,A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.,"Is the triple ""Vancomycin related to nosocomial infection"" supported by the sentence: ""A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections.""?",False, +9057885,Vancomycin related to staphylococcal infection,4623,Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.,"Is the triple ""Vancomycin related to staphylococcal infection"" supported by the sentence: ""Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.""?",False, +8859000,Vancomycin related to endocarditis,4624,"Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.","Is the triple ""Vancomycin related to endocarditis"" supported by the sentence: ""Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae.""?",False, +8170422,Vancomycin related to Sepsis,4625,"DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.","Is the triple ""Vancomycin related to Sepsis"" supported by the sentence: ""DATA COLLECTION AND ANALYSIS: Data regarding clinical outcomes including the overall incidence of sepsis, the incidence of coagulase negative staphylococcal sepsis, mortality, length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms were excerpted from previous clinical trials.""?",False, +23445509,Vancomycin related to peritonitis,4626,Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.,"Is the triple ""Vancomycin related to peritonitis"" supported by the sentence: ""Methods: A total of 558 serum and dialysate samples of 12 episodes of gram-positive and 18 episodes of gram-negative peritonitis were included to investigate the relationship between vancomycin and amikacin concentrations in serum and dialysate on the first and third days of treatment.""?",False, +22719539,Vancomycin related to Infection,4627,"For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).","Is the triple ""Vancomycin related to Infection"" supported by the sentence: ""For MRSA infections, empiric vancomycin monotherapy was associated with an increased odds of treatment failure compared with non-vancomycin or combination anti-MRSA antibiotics, aOR = 3.23 (1.12-9.26).""?",False, +11098147,Vancomycin related to Inflammation,4628,"Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.","Is the triple ""Vancomycin related to Inflammation"" supported by the sentence: ""Among 222 subjects hospitalized for at least 24 hours, toxicity rates were similar for TMP-SMZ (23%) and vancomycin (20%) recipients; nausea and vomiting were associated with TMP-SMZ and inflammation at the intravenous site was associated with vancomycin.""?",False, +14094746,Vancomycin coexists with Peptidoglycan,4629,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, +14094746,Vancomycin coexists with Peptidoglycan,4630,After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.,"Is the triple ""Vancomycin coexists with Peptidoglycan"" supported by the sentence: ""After accumulation of the precursors by inhibition of murein synthesis either in the presence of vancomycin (for the pentapeptide precursor) or D-cycloserine (for the tripeptide precursor) the cells were extracted with boiling water.""?",False, +7840667,Vancomycin physically interacts with Peptidoglycan,4631,Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.,"Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""Bacterial resistance to vancomycin has been attributed to the loss of an intermolecular hydrogen bond between vancomycin and its peptidoglycan target when cell wall biosynthesis proceeds via depsipeptide intermediates rather than the usual polypeptide intermediates.""?",False, +7710804,Vancomycin physically interacts with Peptidoglycan,4632,"The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.","Is the triple ""Vancomycin physically interacts with Peptidoglycan"" supported by the sentence: ""The modified peptidoglycan exhibits a 1, 000-fold decrease in affinity for vancomycin, accounting for the observed phenotypic resistance.""?",False, +26896148,Vancomycin causes endocarditis,4633,Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.,"Is the triple ""Vancomycin causes endocarditis"" supported by the sentence: ""Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium.""?",False, +26320414,Vancomycin causes enterocolitis,4634,"Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.","Is the triple ""Vancomycin causes enterocolitis"" supported by the sentence: ""Ampicillin, vancomycin, erythromycin, cephalosporins, and oral gentamicin caused lethal enterocolitis in most recipients, and all animals which died had evidence of clostridia toxin in cecal contents at necropsy.""?",False, +22849619,Vancomycin causes Infection,4635,"Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).","Is the triple ""Vancomycin causes Infection"" supported by the sentence: ""Soaking grafts in vancomycin resulted in significantly fewer infections (0.013% vs 0.77%; OR 0.07 [0.03, 0.18], p < 0.001).""?",False, +22231760,Vancomycin causes Inflammation,4636,"Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.","Is the triple ""Vancomycin causes Inflammation"" supported by the sentence: ""Furthermore, although gut microbiome diversity did not recover, probiotic supplementation was effective in limiting cecum size enlargement and colonic inflammation caused by vancomycin.""?",False, +21632936,Vancomycin causes bacterial infectious disease with sepsis,4637,"Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.","Is the triple ""Vancomycin causes bacterial infectious disease with sepsis"" supported by the sentence: ""Methods: We report a case in which in vitro pharmacodynamic analyses were utilized to guide the treatment of complex, recurrent bacteremias due to vancomycin-, daptomycin-, and linezolid-resistant Enterococcus faecium and carbapenem-resistant Enterobacter cloacae complex in a liver transplant patient.""?",False, +18945219,Vancomycin causes peritonitis,4638,A literature search identified one other published report of vancomycin-induced EP.,"Is the triple ""Vancomycin causes peritonitis"" supported by the sentence: ""A literature search identified one other published report of vancomycin-induced EP.""?",False, +15481792,Vancomycin causes skin disorder,4639,We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.,"Is the triple ""Vancomycin causes skin disorder"" supported by the sentence: ""We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.""?",False, +12001625,Vancomycin causes kidney failure,4640,"The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.","Is the triple ""Vancomycin causes kidney failure"" supported by the sentence: ""The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.""?",False, +9570250,Vancomycin causes nosocomial infection,4641,Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.,"Is the triple ""Vancomycin causes nosocomial infection"" supported by the sentence: ""Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections.""?",False, +23893373,Vancomycin affects Infection,4642,"CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""CONCLUSION: Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.""?",False, +21581118,Vancomycin affects Infection,4643,"As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.","Is the triple ""Vancomycin affects Infection"" supported by the sentence: ""As an important member, vancomycin often plays an irreplaceable role in some serious infections, but its use still lacks suitable carriers and effective formulations.""?",False, +21291384,Vancomycin affects hematopoietic and lymphoid system neoplasm,4644,"In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.","Is the triple ""Vancomycin affects hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""In addition, multiple regression analysis under adjusting for confounding factors by propensity score, showed that VAN clearance significantly increased in relation to hematologic malignancies.""?",False, +20283933,Vancomycin affects enterocolitis,4645,"Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.","Is the triple ""Vancomycin affects enterocolitis"" supported by the sentence: ""Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals.""?",False, +19879029,Vancomycin affects cystic fibrosis,4646,"Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.","Is the triple ""Vancomycin affects cystic fibrosis"" supported by the sentence: ""Methods: We included subjects who were ?6 years of age, were hospitalized for an APE of CF between May 1, 2012, and April 30, 2014, were administered vancomycin for ?48 hours, and had a history of airway infection with methicillin-resistant Staphylococcus aureus.""?",False, +16899271,Vancomycin affects Sepsis,4647,"CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""CASP sepsis increased the number of rolling leukocytes by 4.5-fold, which was reduced by erythromycin but increased by vancomycin.""?",False, +15270589,Vancomycin affects peritonitis,4648,Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.,"Is the triple ""Vancomycin affects peritonitis"" supported by the sentence: ""Uptake of vancomycin from the peritoneal cavity is enhanced during episodes of peritonitis.""?",False, +13735180,Vancomycin affects pneumonia,4649,"Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.","Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia.""?",False, +12348278,Vancomycin affects Sepsis,4650,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects Sepsis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, +12348277,Vancomycin affects osteomyelitis,4651,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects osteomyelitis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, +12348276,Vancomycin affects endocarditis,4652,"Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.","Is the triple ""Vancomycin affects endocarditis"" supported by the sentence: ""Emergence of reduced vancomycin susceptibility in S. aureus increases the possibility that currently available antimicrobial agents may become ineffective for treating systemic infections, especially bacteraemia, endocarditis and osteomyelitis.""?",False, +7991855,Vancomycin affects Peptidoglycan,4653,These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.,"Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""These data show that CBP-desleucyl-V inhibits peptidoglycan synthesis at the transglycosylation stage in the absence of binding to dipeptide.""?",False, +7527991,Vancomycin affects pneumonia,4654,The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.,"Is the triple ""Vancomycin affects pneumonia"" supported by the sentence: ""The study had to be stopped prematurely because of a new national recommendation of experts to use third generation cephalosporin and vancomycin as a result of the increasing rate of penicillin-resistant S. pneumoniae in France.""?",False, +17707788,Vancomycin affects Peptidoglycan,4655,"In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.","Is the triple ""Vancomycin affects Peptidoglycan"" supported by the sentence: ""In a second step, vancomycin inhibition was relieved by addition of a tripeptide (Lys-D-ala-D-ala) or UDP-MurNAc(pp), resulting in conversion of lipid II to cross-linked peptidoglycan.""?",False, +22719533,Vancomycin disrupts Infection,4656,We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.,"Is the triple ""Vancomycin disrupts Infection"" supported by the sentence: ""We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests.""?",False, +21036263,Vancomycin disrupts osteomyelitis,4657,"More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.","Is the triple ""Vancomycin disrupts osteomyelitis"" supported by the sentence: ""More interestingly, PLA/nHA/VAN, especially PLA/nHA10/VAN8, reduced bone infections and boosted bone regeneration at the defect site with better outcomes than other treatment groups.""?",False, +19924841,Vancomycin disrupts Inflammation,4658,"More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.","Is the triple ""Vancomycin disrupts Inflammation"" supported by the sentence: ""More intriguingly, the lead compound exhibited in vivo efficacy that is much superior to vancomycin by eradicating bacteria and suppressing inflammation caused by MRSA-induced pneumonia in a rat model, demonstrating its promising therapeutic potential.""?",False, +14538194,Vancomycin disrupts enterocolitis,4659,"Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.","Is the triple ""Vancomycin disrupts enterocolitis"" supported by the sentence: ""Zebrafish given vancomycin had bacterial populations dominated by Fusobacteria and reduced enterocolitis scores, intestinal damage, and percentages of infiltrating neutrophils and eosinophils.""?",False, +21888394,Vancomycin prevents bacterial infectious disease,4660,"Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.","Is the triple ""Vancomycin prevents bacterial infectious disease"" supported by the sentence: ""Hence, the nanocomposite fibrous scaffold containing vancomycin can be proposed as a bi-functional graft that can reduce bacterial infection, while subsequently engineer new bone in osteomyelitis.""?",False, +21518539,Vancomycin prevents Infection,4661,Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .,"Is the triple ""Vancomycin prevents Infection"" supported by the sentence: ""Ti6Al4V intramedullary (IM) pins surface-tethered with dopamine methacrylamide (DopaMA) and uniformly coated with PEGDMA-Oligo-Vanco effectively prevented periprosthetic infections in mouse femoral canals inoculated with bioluminescent S. aureus .""?",False, +21292683,Vancomycin prevents osteomyelitis,4662,"CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.","Is the triple ""Vancomycin prevents osteomyelitis"" supported by the sentence: ""CONCLUSIONS: When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis.""?",False, +20759704,Vancomycin prevents kidney failure,4663,Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.,"Is the triple ""Vancomycin prevents kidney failure"" supported by the sentence: ""Our results demonstrate that i.c.v. administration of VCM can be partially prevented from entering the systemic circulation to prevent renal impairments caused by VCM.""?",False, +20759520,Vancomycin prevents arthropathy,4664,"Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.","Is the triple ""Vancomycin prevents arthropathy"" supported by the sentence: ""Conclusions: These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up.""?",False, +16424860,Vancomycin prevents pneumonia,4665,"Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.","Is the triple ""Vancomycin prevents pneumonia"" supported by the sentence: ""Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.""?",False, +11136130,Vancomycin prevents nosocomial infection,4666,"Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.","Is the triple ""Vancomycin prevents nosocomial infection"" supported by the sentence: ""Vancomycin, currently licensed for the MRSA infection, will be highly effective both in vitro and in vivo; however, it examinative of the MRSA isolates in the clinical laboratories, especially to prevent hospital-acquired infections and to follow up the vancomycin susceptibility will be required.""?",False, +8520533,Vancomycin prevents peritonitis,4667,The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.,"Is the triple ""Vancomycin prevents peritonitis"" supported by the sentence: ""The results demonstrate that the microsphere form of cytokine NA is 100% effective in combination with vancomycin in protecting rats from S. aureus-induced peritonitis.""?",False, +8203212,Vancomycin prevents endocarditis,4668,"Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.","Is the triple ""Vancomycin prevents endocarditis"" supported by the sentence: ""Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.""?",False, +8170423,Vancomycin prevents Neonatal sepsis,4669,MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.,"Is the triple ""Vancomycin prevents Neonatal sepsis"" supported by the sentence: ""MAIN RESULTS: The administration of prophylactic vancomycin reduced the incidence of both total neonatal nosocomial sepsis and coagulase negative staphylococcal sepsis in eligible preterm infants.""?",False, +8170420,Vancomycin prevents Sepsis,4670,REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.,"Is the triple ""Vancomycin prevents Sepsis"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: The use of prophylactic vancomycin in low doses reduces the incidence of nosocomial sepsis in the neonate.""?",False, +7111089,Vancomycin prevents Inflammation,4671,We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.,"Is the triple ""Vancomycin prevents Inflammation"" supported by the sentence: ""We attempted to determine whether treatment using intramuscular methylprednisolone plus intravitreal vancomycin decreased ocular inflammation and preserved retinal function better in experimental Staphylococcus aureus (S. aureus) endophthalmitis than treatment with intravitreal vancomycin alone.""?",False, +25178384,Vancomycin exacerbates Inflammation,4672,"Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.","Is the triple ""Vancomycin exacerbates Inflammation"" supported by the sentence: ""Our results demonstrated that vancomycin used in early life could alter the intestinal microecology of mice, which, in turn, aggravates airway inflammation and upregulate type 2 innate lymphocytes.""?",False, +21622859,Vancomycin exacerbates pneumonia,4673,The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.,"Is the triple ""Vancomycin exacerbates pneumonia"" supported by the sentence: ""The characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.OBJECTIVE: This study was designed to investigate the characteristics and impact indicator of vancomycin pharmacokinetics in cancer patients complicated with severe pneumonia.""?",False, +21314122,Vancomycin predisposes Sepsis,4674,"OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.","Is the triple ""Vancomycin predisposes Sepsis"" supported by the sentence: ""OBJECTIVES: To characterize residual vancomycin concentrations (Cmin) and assess the relationships between Cmin, the risk of nephrotoxicity and persistent CoNS sepsis.""?",False, +19879549,Vancomycin predisposes kidney failure,4675,"Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.","Is the triple ""Vancomycin predisposes kidney failure"" supported by the sentence: ""Risk of renal failure may increase in the following situations, such as the combination of intravenous colistin plus intravenous vancomycin, higher doses-colistin, and intravenous colistin combined with inhalational colistin.""?",False, +18555479,Vancomycin predisposes pneumonia,4676,"Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.","Is the triple ""Vancomycin predisposes pneumonia"" supported by the sentence: ""Patients were included if they were at least 65 years old, had an ICD-9-CM code for pneumonia, had one or more HCAP risk factors, and received guideline-concordant antibiotic therapy with linezolid or vancomycin within 48 h of admission.""?",False, +18327103,Vancomycin predisposes nosocomial infection,4677,"CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.","Is the triple ""Vancomycin predisposes nosocomial infection"" supported by the sentence: ""CONCLUSIONS: In hospitalized patients, treatment with intravenous vancomycin within the prior 8 weeks of a first negative PCR test for C difficile is a risk factor for short-term risk for hospital-acquired CDI.""?",False, +12689487,Vancomycin predisposes bacterial infectious disease with sepsis,4678,"CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.","Is the triple ""Vancomycin predisposes bacterial infectious disease with sepsis"" supported by the sentence: ""CONCLUSION: Because vancomycin use was the only variable associated with VRE bacteremia in the two studies, we confirmed that vancomycin exposure is the major risk factor for VRE bacteremia.""?",False, +12018679,LENOGRASTIM related to plasma cell myeloma,4679,We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.,"Is the triple ""LENOGRASTIM related to plasma cell myeloma"" supported by the sentence: ""We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 microg kg once a day) or split dose (5 microg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin's lymphoma (NHL) patients.""?",False, +24207855,SARGRAMOSTIM related to pulmonary alveolar proteinosis,4680,NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.,"Is the triple ""SARGRAMOSTIM related to pulmonary alveolar proteinosis"" supported by the sentence: ""NEBULISED SARGRAMOSTIM IN PULMONARY ALVEOLAR PROTEINOSIS.""?",False, +23712911,SARGRAMOSTIM related to Sepsis,4681,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to Sepsis"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, +23712910,SARGRAMOSTIM related to adult acute respiratory distress syndrome,4682,"Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.","Is the triple ""SARGRAMOSTIM related to adult acute respiratory distress syndrome"" supported by the sentence: ""Sargramostim has the potential to reverse the immune suppression associated with sepsis, trauma, acute respiratory distress syndrome (ARDS) and COVID-19.""?",False, +23177848,SARGRAMOSTIM related to Alzheimer disease,4683,An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.,"Is the triple ""SARGRAMOSTIM related to Alzheimer disease"" supported by the sentence: ""An extended treatment trial testing the long-term safety and efficacy of GM-CSF/sargramostim in AD is warranted.""?",False, +16827749,SARGRAMOSTIM related to prostate cancer,4684,Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.,"Is the triple ""SARGRAMOSTIM related to prostate cancer"" supported by the sentence: ""Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial.""?",False, +11846978,SARGRAMOSTIM related to Crohn disease,4685,Preliminary studies suggest sargramostim may have activity in Crohn's disease.,"Is the triple ""SARGRAMOSTIM related to Crohn disease"" supported by the sentence: ""Preliminary studies suggest sargramostim may have activity in Crohn's disease.""?",False, +7671811,SARGRAMOSTIM related to HIV infectious disease,4686,"Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.","Is the triple ""SARGRAMOSTIM related to HIV infectious disease"" supported by the sentence: ""Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection.""?",False, +7896656,SARGRAMOSTIM prevents neutropenia,4687,Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.,"Is the triple ""SARGRAMOSTIM prevents neutropenia"" supported by the sentence: ""Both filgrastim and sargramostim show promise in treating and preventing neutropenia in HIV-infected patients.""?",False, +27611311,Filgrastim related to sarcoma,4688,Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.,"Is the triple ""Filgrastim related to sarcoma"" supported by the sentence: ""Paclitaxel (Taxol) plus doxorubicin plus filgrastim in advanced sarcoma: a phase II study.""?",False, +26602673,Filgrastim related to acute lymphoblastic leukemia,4689,Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.,"Is the triple ""Filgrastim related to acute lymphoblastic leukemia"" supported by the sentence: ""Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia.""?",False, +26505391,Filgrastim related to Hodgkins lymphoma,4690,"CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.","Is the triple ""Filgrastim related to Hodgkins lymphoma"" supported by the sentence: ""CONCLUSIONS: In conclusion, our data suggest the use of Filgrastim in Hodgkin's disease also during conventional-dose chemotherapy with ABVD.""?",False, +23038064,Filgrastim related to Infection,4691,"RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.","Is the triple ""Filgrastim related to Infection"" supported by the sentence: ""RESULTS: We hypothesized that patients receiving pegfilgrastim will achieve similar median and average dose levels of DA-EPOCH, event-free survival rates, overall response rates, completion of at least twice weekly CBC monitoring, and incidence of infections, FN, hospitalizations for infections or FN, and bone pain compared to patients receiving filgrastim.""?",False, +22749433,Filgrastim related to neoplasm,4692,"Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.","Is the triple ""Filgrastim related to neoplasm"" supported by the sentence: ""Following an overview of the synthesis, structure and function of G-CSF and its receptor, the remainder of this review is focused on: (i) effects of G-CSF on the cells of the adaptive and innate immune systems; (ii) mechanisms by which this cytokine promotes tumor progression and invasion; and (iii) current clinical applications and potential risks of the use of rG-CSF in medical oncology.""?",False, +19713781,Filgrastim related to lymphoma,4693,A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.,"Is the triple ""Filgrastim related to lymphoma"" supported by the sentence: ""A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity-score weighted multicenter approach.""?",False, +18903615,Filgrastim related to HIV infectious disease,4694,"Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.","Is the triple ""Filgrastim related to HIV infectious disease"" supported by the sentence: ""Tbo-filgrastim (filgrastim XM02; Biograstim((r)), Ratiograstim((r)), Tevagrastim((r))) is approved in the EU as a biosimilar of filgrastim (Neupogen((r))) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection.""?",False, +17402873,Filgrastim related to acute myeloid leukemia,4695,"Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.","Is the triple ""Filgrastim related to acute myeloid leukemia"" supported by the sentence: ""Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.""?",False, +16080456,Filgrastim related to plasma cell myeloma,4696,"Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).","Is the triple ""Filgrastim related to plasma cell myeloma"" supported by the sentence: ""Within a growth factor-based strategy (6 articles), addition of plerixafor improves CD34+ cell yield over filgrastim alone in multiple myeloma (MM; 11.0 vs 6.2 * 10(6)/kg; P < .001) and non-Hodgkin lymphoma (5.69 vs 1.98 * 10(6)/kg; P < .01).""?",False, +14467347,Filgrastim related to myocardial infarction,4697,"Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.","Is the triple ""Filgrastim related to myocardial infarction"" supported by the sentence: ""Myocardial infarction, atrial fibrillation and arrhythmia have been reported in several patients with malignancy receiving filgrastim, but a causal relationship with the drug has not been established.""?",False, +13860825,Filgrastim related to small cell lung carcinoma,4698,Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.,"Is the triple ""Filgrastim related to small cell lung carcinoma"" supported by the sentence: ""Final results of a placebo-controlled study of filgrastim in small-cell lung cancer: exploration of risk factors for febrile neutropenia.""?",False, +10253688,Filgrastim related to ovarian cancer,4699,"Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.","Is the triple ""Filgrastim related to ovarian cancer"" supported by the sentence: ""Phase III trial of paclitaxel at two dose levels, the higher dose accompanied by filgrastim at two dose levels in platinum-pretreated epithelial ovarian cancer: an intergroup study.""?",False, +9334871,Filgrastim related to non-small cell lung carcinoma,4700,"A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.","Is the triple ""Filgrastim related to non-small cell lung carcinoma"" supported by the sentence: ""A Mayo phase I trial of edatrexate (E), vinblastine (V), doxorubicin (Adriamycin) (A), cisplatin (C), and filgrastim (GCSF), (EVAC-GCSF) showed promising antineoplastic activity in non-small-cell lung cancer (NSCLC) (Colon-Otero G, et al.""?",False, +7868897,Filgrastim related to neutropenia,4701,"Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.","Is the triple ""Filgrastim related to neutropenia"" supported by the sentence: ""Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality.""?",False, +7775323,Filgrastim related to non-Hodgkin lymphoma,4702,Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.,"Is the triple ""Filgrastim related to non-Hodgkin lymphoma"" supported by the sentence: ""Costs of peripheral blood progenitor cell transplantation using whole blood mobilised by filgrastim as compared with autologous bone marrow transplantation in non-Hodgkin's lymphoma.""?",False, +13176527,Filgrastim has part non-Hodgkin lymphoma,4703,Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.,"Is the triple ""Filgrastim has part non-Hodgkin lymphoma"" supported by the sentence: ""Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients.""?",False, +27488127,Filgrastim causes acute myeloid leukemia,4704,"The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.","Is the triple ""Filgrastim causes acute myeloid leukemia"" supported by the sentence: ""The safety and efficacy of filgrastim as an adjunct to acute myeloid leukemia (AML) induction and consolidation therapy was assessed in this prospective double-blind, randomized, placebo-controlled, multicenter trial.""?",False, +26596932,Filgrastim causes acute lymphoblastic leukemia,4705,Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.,"Is the triple ""Filgrastim causes acute lymphoblastic leukemia"" supported by the sentence: ""Our purpose was to evaluate the ability of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemotherapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time.""?",False, +19245347,Filgrastim causes myeloproliferative neoplasm,4706,Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.,"Is the triple ""Filgrastim causes myeloproliferative neoplasm"" supported by the sentence: ""Myeloproliferative neoplasms after organ transplant or due to filgrastim are rare.""?",False, +8419399,Filgrastim causes neutropenia,4707,Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.,"Is the triple ""Filgrastim causes neutropenia"" supported by the sentence: ""Use of Filgrastim for Ticlopidine Induced Neutropenia Following Coronary Stenting.""?",False, +26496059,Filgrastim affects neutropenia,4708,"The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.","Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""The use of filgrastim with increasing doses of chemotherapy prevents neutropenia, but other toxicities, namely thrombocytopenia and lethargy, then become dose limiting.""?",False, +15351355,Filgrastim affects Fever,4709,"Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.","Is the triple ""Filgrastim affects Fever"" supported by the sentence: ""Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.""?",False, +7868413,Filgrastim affects neutropenia,4710,Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.,"Is the triple ""Filgrastim affects neutropenia"" supported by the sentence: ""Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections.""?",False, +9501874,Filgrastim disrupts neutropenia,4711,Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.,"Is the triple ""Filgrastim disrupts neutropenia"" supported by the sentence: ""Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia.""?",False, +14309803,Filgrastim prevents non-Hodgkin lymphoma,4712,"The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).","Is the triple ""Filgrastim prevents non-Hodgkin lymphoma"" supported by the sentence: ""The aim of the present study was to investigate a new G-CSF, XM02, in comparison to filgrastim in terms of safety and efficacy in the prevention of chemotherapy-induced neutropenia in non-Hodgkin-lymphoma (NHL).""?",False, +7265196,Filgrastim prevents neutropenia,4713,We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.,"Is the triple ""Filgrastim prevents neutropenia"" supported by the sentence: ""We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile episodes.""?",False, +16134815,Filgrastim predisposes hematopoietic and lymphoid system neoplasm,4714,BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.,"Is the triple ""Filgrastim predisposes hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""BACKGROUNDS: Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.""?",False, +14495646,Filgrastim predisposes neutropenia,4715,"Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.","Is the triple ""Filgrastim predisposes neutropenia"" supported by the sentence: ""Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-induced neutropenia.""?",False, +12306052,Tibolone affects physiological sexual disorder,4716,"Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.","Is the triple ""Tibolone affects physiological sexual disorder"" supported by the sentence: ""Few randomised controlled studies have been done, and there is evidence suggesting that systemic hormone therapy, such as estrogen, estrogen/progesterone, estrogen/testosterone and tibolone, has a positive impact on sexual dysfunction in the menopause.""?",False, +7873396,Tibolone prevents osteoporosis,4717,"In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.","Is the triple ""Tibolone prevents osteoporosis"" supported by the sentence: ""In recent years a wide variety of therapies, for example hormone replacement therapy, calcium supplements administered with vitamin D metabolites, thiazides, diuretics, anabolic steroids, tibolone, calcitonin and bisphosphonates, have been proposed to prevent osteoporosis in patients receiving longterm corticosteroid therapy, but there have been few carefully controlled trials, except for vitamin D and bisphosphonates.""?",False, +17565484,Cosyntropin affects West syndrome,4718,"TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.","Is the triple ""Cosyntropin affects West syndrome"" supported by the sentence: ""TCS-induced Glx reduction may induce changes in synaptic signal transduction, thereby accounting for the effect of TCS on WS.""?",False, +11757081,Cosyntropin disrupts hypertensive disorder,4719,In one child synthetic ACTH was stopped because of arterial hypertension.,"Is the triple ""Cosyntropin disrupts hypertensive disorder"" supported by the sentence: ""In one child synthetic ACTH was stopped because of arterial hypertension.""?",False, +19585114,Corticotropin related to chronic progressive multiple sclerosis,4720,Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.,"Is the triple ""Corticotropin related to chronic progressive multiple sclerosis"" supported by the sentence: ""Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.""?",False, +15839924,Corticotropin related to membranous glomerulonephritis,4721,The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.,"Is the triple ""Corticotropin related to membranous glomerulonephritis"" supported by the sentence: ""The initial experience in Europe using synthetic ACTH in membranous nephropathy led to a randomized trial in which ACTH performed comparably to a combined regimen of steroids and alkylating agents.""?",False, +10947313,Corticotropin related to polycystic ovary syndrome,4722,"CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.","Is the triple ""Corticotropin related to polycystic ovary syndrome"" supported by the sentence: ""CONCLUSION(S): Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS.""?",False, +10518316,Corticotropin related to dermatomyositis,4723,Corticotrophin and cortisone therapy in dermatomyositis.,"Is the triple ""Corticotropin related to dermatomyositis"" supported by the sentence: ""Corticotrophin and cortisone therapy in dermatomyositis.""?",False, +10489579,Corticotropin related to epilepsy,4724,[Observations on several cases of epilepsy in children with ACTH and cortisone].,"Is the triple ""Corticotropin related to epilepsy"" supported by the sentence: ""[Observations on several cases of epilepsy in children with ACTH and cortisone].""?",False, +10438408,Corticotropin related to nephrotic syndrome,4725,Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.,"Is the triple ""Corticotropin related to nephrotic syndrome"" supported by the sentence: ""Prolonged intermittent corticotropin (ACTH) and cortisone therapy in the nephrotic syndrome: immunologic basis and results.""?",False, +10431205,Corticotropin related to sarcoidosis,4726,[ACTH and cortisone in sarcoidosis; preliminary report].,"Is the triple ""Corticotropin related to sarcoidosis"" supported by the sentence: ""[ACTH and cortisone in sarcoidosis; preliminary report].""?",False, +10427009,Corticotropin related to optic neuritis,4727,Intravenous use of corticotropin in optic neuritis.,"Is the triple ""Corticotropin related to optic neuritis"" supported by the sentence: ""Intravenous use of corticotropin in optic neuritis.""?",False, +9718321,Corticotropin related to rheumatoid arthritis,4728,"ACTH, cortisol and prolactin in active rheumatoid arthritis.","Is the triple ""Corticotropin related to rheumatoid arthritis"" supported by the sentence: ""ACTH, cortisol and prolactin in active rheumatoid arthritis.""?",False, +8496620,Corticotropin related to multiple sclerosis,4729,Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.,"Is the triple ""Corticotropin related to multiple sclerosis"" supported by the sentence: ""Corticosteroids or ACTH for acute exacerbations in multiple sclerosis.""?",False, +7394246,Corticotropin related to West syndrome,4730,ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.,"Is the triple ""Corticotropin related to West syndrome"" supported by the sentence: ""ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.""?",False, +22849896,Corticotropin causes West syndrome,4731,Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.,"Is the triple ""Corticotropin causes West syndrome"" supported by the sentence: ""Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms.""?",False, +12436107,Corticotropin causes epilepsy,4732,"The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.","Is the triple ""Corticotropin causes epilepsy"" supported by the sentence: ""The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility.""?",False, +11010111,Corticotropin causes rheumatoid arthritis,4733,The natural course of rheumatoid arthritis and the changes induced by ACTH.,"Is the triple ""Corticotropin causes rheumatoid arthritis"" supported by the sentence: ""The natural course of rheumatoid arthritis and the changes induced by ACTH.""?",False, +17565428,Corticotropin affects West syndrome,4734,Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.,"Is the triple ""Corticotropin affects West syndrome"" supported by the sentence: ""Abnormalities of serotonergic neurotransmission have been suggested in the ACTH-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-HT) levels and induction of infantile spasms in Down's syndrome by the 5-HT precursor 5-hydroxytryptophan.""?",False, +15783986,Corticotropin affects multiple sclerosis,4735,"At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.","Is the triple ""Corticotropin affects multiple sclerosis"" supported by the sentence: ""At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration.""?",False, +15695412,Corticotropin affects polycystic ovary syndrome,4736,Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.,"Is the triple ""Corticotropin affects polycystic ovary syndrome"" supported by the sentence: ""Five other patients showed PCOD secondary to nonclassic 21-hydroxylase defect diagnosed on the basis of high 17-hydroxyprogesterone plasma values and highly responsive to ACTH.""?",False, +11427275,Corticotropin affects dermatomyositis,4737,The effect of pituitary adrenocorticotropin in dermatomyositis.,"Is the triple ""Corticotropin affects dermatomyositis"" supported by the sentence: ""The effect of pituitary adrenocorticotropin in dermatomyositis.""?",False, +10737513,Corticotropin affects sarcoidosis,4738,The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).,"Is the triple ""Corticotropin affects sarcoidosis"" supported by the sentence: ""The effect of ACTH on sarcoidosis; (Besnier-Boeck-Schaumann).""?",False, +10422766,Corticotropin affects rheumatoid arthritis,4739,On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.,"Is the triple ""Corticotropin affects rheumatoid arthritis"" supported by the sentence: ""On the connection between the clinical effect of corticotropin on rheumatoid arthritis and the serum proteins before and during treatment.""?",False, +9312832,Corticotropin affects epilepsy,4740,"The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).","Is the triple ""Corticotropin affects epilepsy"" supported by the sentence: ""The initial effects of ACTH on seizures and long-term outcome were not dose dependent (daily dosage 0.005 to 0.032 mg/kg, 0.2 to 1.28 IU/kg; total dosage 0.1 to 0.87 mg/kg, 4 to 34.8 IU/kg).""?",False, +15159690,Corticotropin disrupts epilepsy,4741,AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.,"Is the triple ""Corticotropin disrupts epilepsy"" supported by the sentence: ""AIM: Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms.""?",False, +27033387,Corticotropin prevents West syndrome,4742,Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.,"Is the triple ""Corticotropin prevents West syndrome"" supported by the sentence: ""Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms.""?",False, +10517176,Corticotropin prevents epilepsy,4743,"Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.","Is the triple ""Corticotropin prevents epilepsy"" supported by the sentence: ""Whereas ACTH-(1-39), ACTH-(1-24), ACTH-(1-18), ACTH-(1-16) and ACTH-(18-39) were not active, subcutaneous pretreatment with smaller ACTH-like fragments, such as ACTH-(4-9), ACTH-(4-10), ACTH-(4-10)(7D-Phe), ACTH-(7-16), and Org2766, reduced the severity of the epilepsy.""?",False, +23224982,Corticotropin predisposes epilepsy,4744,"The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.","Is the triple ""Corticotropin predisposes epilepsy"" supported by the sentence: ""The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment.""?",False, +15800284,Dabigatran etexilate related to atrial fibrillation,4745,"In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.","Is the triple ""Dabigatran etexilate related to atrial fibrillation"" supported by the sentence: ""In particular, the novel, oral, direct thrombin inhibitor, dabigatran etexilate, recently licensed by the US Food and Drug Administration (FDA) and Health Canada has shown improved efficacy and safety compared with warfarin for stroke prevention in AF, and has the potential to replace warfarin in this indication.""?",False, +16972150,Dabigatran etexilate affects stroke disorder,4746,This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.,"Is the triple ""Dabigatran etexilate affects stroke disorder"" supported by the sentence: ""This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries.""?",False, +21262475,Dabigatran etexilate prevents thrombophilia due to thrombin defect,4747,Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.,"Is the triple ""Dabigatran etexilate prevents thrombophilia due to thrombin defect"" supported by the sentence: ""Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT.""?",False, +19084221,Dabigatran etexilate prevents thrombotic disease,4748,"A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.","Is the triple ""Dabigatran etexilate prevents thrombotic disease"" supported by the sentence: ""A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor (DTI) dabigatran), has been used clinically to prevent thrombosis.""?",False, +14524874,Dabigatran etexilate prevents stroke disorder,4749,"Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.","Is the triple ""Dabigatran etexilate prevents stroke disorder"" supported by the sentence: ""Ongoing phase III trials are now evaluating the long-term use of dabigatran etexilate for the treatment and secondary prevention of VTE and for prevention of stroke in patients with atrial fibrillation, as a replacement for VKAs.""?",False, +11599698,Dabigatran etexilate prevents Thromboembolism,4750,"A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.","Is the triple ""Dabigatran etexilate prevents Thromboembolism"" supported by the sentence: ""A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial.""?",False, +15929248,Dabigatran etexilate predisposes stroke disorder,4751,"Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.","Is the triple ""Dabigatran etexilate predisposes stroke disorder"" supported by the sentence: ""Dabigatran etexilate, approved in the United States in October 2010 for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, now offers the first oral alternative to warfarin for patients with atrial fibrillation.""?",False, +13343476,Dabigatran etexilate predisposes Thromboembolism,4752,"INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.","Is the triple ""Dabigatran etexilate predisposes Thromboembolism"" supported by the sentence: ""INTERPRETATION: Oral dabigatran etexilate was as effective as enoxaparin in reducing the risk of venous thromboembolism after total hip replacement surgery, with a similar safety profile.""?",False, +10867084,Ximelagatran related to atrial fibrillation,4753,Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.,"Is the triple ""Ximelagatran related to atrial fibrillation"" supported by the sentence: ""Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial fibrillation.""?",False, +12162541,Ximelagatran prevents thrombotic disease,4754,A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.,"Is the triple ""Ximelagatran prevents thrombotic disease"" supported by the sentence: ""A Phase III trial demonstrated that ximelagatran was superior to placebo for preventing recurrent thrombosis in patients who had undergone six months of standard anticoagulant therapy for venous thromboembolism.""?",False, +9396435,Ximelagatran prevents Thromboembolism,4755,"In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.","Is the triple ""Ximelagatran prevents Thromboembolism"" supported by the sentence: ""In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery.""?",False, +13148663,Ximelagatran predisposes Thromboembolism,4756,"OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.","Is the triple ""Ximelagatran predisposes Thromboembolism"" supported by the sentence: ""OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery.""?",False, +24220155,Bivalirudin related to Hemorrhage,4757,"CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""CONCLUSION: Bivalirudin is well tolerated with low ADRs, thrombocytopenia and bleeding incidences in Chinese female patients undergoing PCI.""?",False, +23845334,Bivalirudin related to thrombocytopenia,4758,"Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).","Is the triple ""Bivalirudin related to thrombocytopenia"" supported by the sentence: ""Anticoagulation with bivalirudin was associated with higher survival, compared with heparin (55% v 31%, p = 0.03), and lower thrombocytopenia incidence (69% v 35%, p = 0.003).""?",False, +21128552,Bivalirudin related to heart disorder,4759,"AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.","Is the triple ""Bivalirudin related to heart disorder"" supported by the sentence: ""AIMS: In the Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART), bivalirudin was not superior to unfractionated heparin in patients with acute coronary syndrome undergoing invasive management.""?",False, +16166302,Bivalirudin related to coronary artery disorder,4760,Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.,"Is the triple ""Bivalirudin related to coronary artery disorder"" supported by the sentence: ""Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients.""?",False, +9469606,Bivalirudin related to myocardial infarction,4761,"Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.","Is the triple ""Bivalirudin related to myocardial infarction"" supported by the sentence: ""Data from a meta-analysis of four randomised trials among patients undergoing PTCA or treatment for acute coronary syndromes indicate that, at after 30 to 50 days of follow-up, bivalirudin was significantly more effective than heparin in reducing the incidence of nonfatal MI and the combined endpoint of death or nonfatal MI.""?",False, +9060136,Bivalirudin related to acute coronary syndrome,4762,Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.,"Is the triple ""Bivalirudin related to acute coronary syndrome"" supported by the sentence: ""Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes.""?",False, +21743704,Bivalirudin related to Hemorrhage,4763,"On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.","Is the triple ""Bivalirudin related to Hemorrhage"" supported by the sentence: ""On subgroup analyses based on the use of GPI in the heparin arm, benefit of major bleeding associated with bivalirudin appeared to be equally evident when GPI was used as a bailout (0.66 [0.46-0.94], p = 0.02) versus routine (0.67 [0.51-0.88], p = 0.004) adjunctive therapy with heparin.""?",False, +18003165,Bivalirudin related to thrombotic disease,4764,"CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.","Is the triple ""Bivalirudin related to thrombotic disease"" supported by the sentence: ""CONCLUSION: Meta-analysis of 14 RCTs with 30,446 patients demonstrated that bivalirudin is associated with higher risk of stent thrombosis but lower risk of major bleeding compared with heparin.""?",False, +15575490,Bivalirudin causes myocardial infarction,4765,These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.,"Is the triple ""Bivalirudin causes myocardial infarction"" supported by the sentence: ""These trials suggest that prolonged bivalirudin infusions result in less periprocedural myocardial infarction with no increase in bleeding compared to intraprocedural only bivalirudin.""?",False, +10298579,Bivalirudin causes Hemorrhage,4766,"However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).","Is the triple ""Bivalirudin causes Hemorrhage"" supported by the sentence: ""However, the known pharmacological properties of bivalirudin could result in hemorrhage in the presence of an appropriate challenge (e.g., blood collection).""?",False, +19056194,Bivalirudin affects thrombotic disease,4767,Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.""?",False, +15575489,Bivalirudin affects thrombotic disease,4768,DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).,"Is the triple ""Bivalirudin affects thrombotic disease"" supported by the sentence: ""DISCUSSION: A small increase in stent thrombosis and ischemic events has been identified in large clinical trials using bivalirudin for acute coronary syndromes (ACS).""?",False, +14748514,Bivalirudin affects myocardial infarction,4769,"Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.","Is the triple ""Bivalirudin affects myocardial infarction"" supported by the sentence: ""Given the individual patient risk profiles and the fact that bivalirudin prevented approximately 6 major bleeds for each MI that might occur from its use, the estimated reduction in bleeding was greater than the estimated increase in MI by bivalirudin alone rather than heparin plus a glycoprotein IIb/IIIa inhibitor for nearly all patients.""?",False, +14318099,Bivalirudin affects Hemorrhage,4770,Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.,"Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""Impact of bivalirudin on in-hospital bleeding and six-month outcomes in octogenarians undergoing percutaneous coronary intervention.""?",False, +9597163,Bivalirudin affects Hemorrhage,4771,"In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.","Is the triple ""Bivalirudin affects Hemorrhage"" supported by the sentence: ""In all models assessed, the use of bivalirudin offset most of its own cost through reductions in bleeding and ischemic complications.""?",False, +19316921,Bivalirudin disrupts myocardial infarction,4772,"CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.","Is the triple ""Bivalirudin disrupts myocardial infarction"" supported by the sentence: ""CONCLUSIONS: Our network meta-analysis of 38,645 patients demonstrated that GPI regimens were associated with a reduction in recurrent myocardial infarction or major adverse cardiovascular events for PCI, while bivalirudin was associated with the lowest risk of bleeding.""?",False, +19056195,Bivalirudin disrupts thrombotic disease,4773,"BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.","Is the triple ""Bivalirudin disrupts thrombotic disease"" supported by the sentence: ""BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST.""?",False, +13525067,Bivalirudin disrupts acute coronary syndrome,4774,Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.,"Is the triple ""Bivalirudin disrupts acute coronary syndrome"" supported by the sentence: ""Efficacy and safety of bivalirudin versus heparins in reduction of cardiac outcomes in acute coronary syndrome and percutaneous coronary interventions.""?",False, +13434992,Bivalirudin disrupts Hemorrhage,4775,"Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.","Is the triple ""Bivalirudin disrupts Hemorrhage"" supported by the sentence: ""Finally, the ACUITY trial found that in moderate or high risk Non ST elevation ACS patients triaged to PCI, coronary artery bypass graft (CABG) surgery, or medical management, bivalirudin, with or without associated GPIIb/IIIa inhibitor therapy, resulted in a marked reduction of bleeding at 30 days whilst preserving the ischemic and mortality benefit at 1 year follow up.""?",False, +21793150,Bivalirudin prevents Hemorrhage,4776,Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.,"Is the triple ""Bivalirudin prevents Hemorrhage"" supported by the sentence: ""Bivalirudin reduced bleeding in both VP and non-VP with a larger absolute benefit in VP.""?",False, +20637086,Bivalirudin prevents syndromic disease,4777,Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.,"Is the triple ""Bivalirudin prevents syndromic disease"" supported by the sentence: ""Bivalirudin fails to prevent atrial thrombus development in heparin-induced thrombocytopaenia and thrombosis syndrome.""?",False, +17823880,Bivalirudin prevents myocardial infarction,4778,"This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).","Is the triple ""Bivalirudin prevents myocardial infarction"" supported by the sentence: ""This effect was larger in the RA group, where bivalirudin significantly reduced periprocedural MI (15.7% vs. 38.7%, p=0.01) with a trend towards reduced major ASB (2.9% vs. 10.2%, p=0.09).""?",False, +10215156,Bivalirudin prevents thrombotic disease,4779,Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.,"Is the triple ""Bivalirudin prevents thrombotic disease"" supported by the sentence: ""Bivalirudin (an anti-thrombin oligopeptide) has been approved for preventing thrombosis in unstable angina patients following angioplasty in adjunct to aspirin.""?",False, +22425248,Bivalirudin predisposes Hemorrhage,4780,"Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.","Is the triple ""Bivalirudin predisposes Hemorrhage"" supported by the sentence: ""Conclusion: The risk of bleeding and the incidence of NACE are significantly lower for patients using bivalirudin during perioperative period of PCI compared to heparin, without significant differences in ischemic events.""?",False, +16276306,Bivalirudin predisposes thrombotic disease,4781,"Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.","Is the triple ""Bivalirudin predisposes thrombotic disease"" supported by the sentence: ""Owing to the pharmacodynamic properties of bivalirudin, areas of blood stagnation should be carefully avoided in order to limit the risk of thrombosis.""?",False, +14172527,Bivalirudin predisposes myocardial infarction,4782,A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).,"Is the triple ""Bivalirudin predisposes myocardial infarction"" supported by the sentence: ""A reduction in the bleeding risk inversely correlated with an increase in the risk of myocardial infarction with bivalirudin (R = -0.61).""?",False, +17086386,Melagatran disrupts thrombotic disease,4783,"The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.","Is the triple ""Melagatran disrupts thrombotic disease"" supported by the sentence: ""The doses required for 50% inhibition of thrombosis of edoxaban, melagatran, and heparin were 0.045mg/kg/h, 0.14mg/kg/h, and 55U/kg/h, respectively.""?",False, +9182682,Lepirudin related to thrombotic disease,4784,"Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.","Is the triple ""Lepirudin related to thrombotic disease"" supported by the sentence: ""Recombinant hirudin (Refludan, Hoechst Marion Roussel) is a direct thrombin inhibitor indicated for anticoagulation in HITT and approved by the United States Food and Drug Administration.""?",False, +27183131,Lepirudin affects thrombotic disease,4785,Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.,"Is the triple ""Lepirudin affects thrombotic disease"" supported by the sentence: ""Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models.""?",False, +26612130,Lepirudin disrupts thrombotic disease,4786,Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.,"Is the triple ""Lepirudin disrupts thrombotic disease"" supported by the sentence: ""Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor.""?",False, +9038512,Lepirudin prevents thrombotic disease,4787,"Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.","Is the triple ""Lepirudin prevents thrombotic disease"" supported by the sentence: ""Lepirudin effectively prevented acute thrombosis in both of our patients with documented HIT, with no bleeding complications.""?",False, +24074121,Ripasudil affects Fuchs' endothelial dystrophy,4788,"Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).","Is the triple ""Ripasudil affects Fuchs' endothelial dystrophy"" supported by the sentence: ""Conclusions and Importance: These cases expand upon the reported effects of rho-associated kinase inhibitor Ripasudil in the FECD, suggesting a role as adjuvant medical therapy in patients advised for intraocular surgery to improve endothelial function and reduce the risk of pseudophakic bullous keratopathy (PBK).""?",False, +23144840,Netarsudil prevents corneal edema,4789,CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.,"Is the triple ""Netarsudil prevents corneal edema"" supported by the sentence: ""CONCLUSIONS: Use of netarsudil was associated with reduction of corneal edema and improvement in scotopic CDVA in Fuchs dystrophy patients.""?",False, +21457868,Netarsudil prevents open-angle glaucoma,4790,Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.,"Is the triple ""Netarsudil prevents open-angle glaucoma"" supported by the sentence: ""Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension.""?",False, +25249408,Calcitriol related to Hypocalcemia,4791,We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.,"Is the triple ""Calcitriol related to Hypocalcemia"" supported by the sentence: ""We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats.""?",False, +24424216,Calcitriol related to Crohn disease,4792,"From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].","Is the triple ""Calcitriol related to Crohn disease"" supported by the sentence: ""From these studies, we determined that LL-37 and calcitriol were significantly lower in CD samples from MAP-positive patients [155.55 +/- 49.77 ng/mL and 51.48 +/- 31.04 pg/mL, respectively] compared to MAP-negative patients [193.01 +/- 78.95 ng/mL and 272.36 +/- 94.77 pg/mL, respectively].""?",False, +23057137,Calcitriol related to acute kidney failure,4793,Production and metabolic clearance of calcitriol in acute renal failure.,"Is the triple ""Calcitriol related to acute kidney failure"" supported by the sentence: ""Production and metabolic clearance of calcitriol in acute renal failure.""?",False, +21048179,Calcitriol related to breast neoplasm,4794,"In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.","Is the triple ""Calcitriol related to breast neoplasm"" supported by the sentence: ""In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.""?",False, +18873537,Calcitriol related to diabetic kidney disease,4795,"The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.","Is the triple ""Calcitriol related to diabetic kidney disease"" supported by the sentence: ""The renoprotective effects of calcitriol in diabetic nephropathy were related to the regulation of tubular levels of ACE and ACE2, possibly by p38 MAPK or ERK, but not JNK pathways.""?",False, +17759117,Calcitriol related to Sepsis,4796,Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.,"Is the triple ""Calcitriol related to Sepsis"" supported by the sentence: ""Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted.""?",False, +17014883,Calcitriol related to hypoparathyroidism,4797,We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.,"Is the triple ""Calcitriol related to hypoparathyroidism"" supported by the sentence: ""We treated a hypoparathyroid woman with calcitriol during pregnancy and did not reduce the dosage after delivery.""?",False, +16783681,Calcitriol related to non-small cell lung carcinoma,4798,A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.,"Is the triple ""Calcitriol related to non-small cell lung carcinoma"" supported by the sentence: ""A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.""?",False, +16670490,Calcitriol related to postmenopausal osteoporosis,4799,Long-term treatment with calcitriol in postmenopausal osteoporosis.,"Is the triple ""Calcitriol related to postmenopausal osteoporosis"" supported by the sentence: ""Long-term treatment with calcitriol in postmenopausal osteoporosis.""?",False, +16084679,Calcitriol related to hypertensive disorder,4800,"AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.","Is the triple ""Calcitriol related to hypertensive disorder"" supported by the sentence: ""AIMS: The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction.""?",False, +15183062,Calcitriol related to type 1 diabetes mellitus,4801,OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.,"Is the triple ""Calcitriol related to type 1 diabetes mellitus"" supported by the sentence: ""OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.""?",False, +13574949,Calcitriol related to neoplasm,4802,"We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.","Is the triple ""Calcitriol related to neoplasm"" supported by the sentence: ""We examine here, the effect of calcitriol and cisplatin pre-clinically and clinically in canine spontaneous tumors through in vitro studies on tumor cells and through a phase I study of calcitriol and cisplatin to identify the maximum-tolerated dosage (MTD) of this combination in dogs with cancer and to characterize the pharmacokinetic disposition of calcitriol in dogs.""?",False, +13228040,Calcitriol related to castration-resistant prostate carcinoma,4803,"Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.","Is the triple ""Calcitriol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Preliminary data suggest a potential role of high-dose calcitriol and thalidomide in hormone-refractory prostate cancer, whereas targeted therapies in bladder and testicular cancers are still more or less limited to single-case experiences.""?",False, +11632117,Calcitriol related to prostate cancer,4804,Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.,"Is the triple ""Calcitriol related to prostate cancer"" supported by the sentence: ""Rationale for the development and current status of calcitriol in androgen-independent prostate cancer.""?",False, +11549262,Calcitriol related to renal osteodystrophy,4805,"In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.","Is the triple ""Calcitriol related to renal osteodystrophy"" supported by the sentence: ""In Japan, three oral preparations (calcitriol, alfacalcidol and falecalcitriol) and two intravenous preparations (calcitriol and maxacalcitol) are now available for the vitamin D(3) therapy in renal osteodystrophy.""?",False, +11138207,Calcitriol related to skin basal cell carcinoma,4806,"RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.","Is the triple ""Calcitriol related to skin basal cell carcinoma"" supported by the sentence: ""RNA expression of vitamin D receptor (VDR) and of main enzymes involved in synthesis and metabolism of calcitriol (vitamin D-25-hydroxylase [25-OHase], 25-hydroxyvitamin D-1alpha-hydroxylase [1alpha-OHase], 1,25-dihydroxyvitamin D-24-hydroxylase [24-OHase]) was detected in BCCs and NS.""?",False, +9056874,Calcitriol related to psoriasis,4807,"Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.","Is the triple ""Calcitriol related to psoriasis"" supported by the sentence: ""Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.""?",False, +8335532,Calcitriol related to chronic kidney disease,4808,This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.,"Is the triple ""Calcitriol related to chronic kidney disease"" supported by the sentence: ""This article summarizes the separate and combined effects of growth hormone and calcitriol on endochondral bone formation in chronic renal failure and secondary hyperparathyroidism.""?",False, +7638906,Calcitriol related to myelodysplastic syndrome,4809,Calcitriol in myelodysplastic syndromes.,"Is the triple ""Calcitriol related to myelodysplastic syndrome"" supported by the sentence: ""Calcitriol in myelodysplastic syndromes.""?",False, +7210521,Calcitriol related to osteoporosis,4810,"To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.","Is the triple ""Calcitriol related to osteoporosis"" supported by the sentence: ""To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure.""?",False, +23300761,Calcitriol causes hypoparathyroidism,4811,Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.,"Is the triple ""Calcitriol causes hypoparathyroidism"" supported by the sentence: ""Therapy with PTH 1-34 or Calcitriol and Calcium in Diverse Etiologies of Hypoparathyroidism over 27 Years at a Single Tertiary Care Center.""?",False, +22190855,Calcitriol causes Hypocalcemia,4812,"At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.","Is the triple ""Calcitriol causes Hypocalcemia"" supported by the sentence: ""At 3 years and 3 months since the diagnosis of hypoparathyroidism, PTH was still inappropriately low at 7.6 pg/mL, and attempted discontinuation of calcium and calcitriol resulted in recurrent symptomatic hypocalcemia.""?",False, +13672029,Calcitriol causes renal osteodystrophy,4813,"Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.","Is the triple ""Calcitriol causes renal osteodystrophy"" supported by the sentence: ""Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease.""?",False, +8610431,Calcitriol causes neoplasm,4814,In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.,"Is the triple ""Calcitriol causes neoplasm"" supported by the sentence: ""In vivo studies were performed by weekly intravesical instillation of calcitriol in female Fischer 344 rats after induction of tumors by N-methyl nitrosourea.""?",False, +26699785,Calcitriol affects myelodysplastic syndrome,4815,"Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.","Is the triple ""Calcitriol affects myelodysplastic syndrome"" supported by the sentence: ""Ubenimex, calcitriol and corticosteroid had a minor effect on her MDS.""?",False, +26649101,Calcitriol affects psoriasis,4816,Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.,"Is the triple ""Calcitriol affects psoriasis"" supported by the sentence: ""Effect of calcitriol treatment on psoriasis in hemodialysis patient: a case report.""?",False, +20118335,Calcitriol affects chronic kidney disease,4817,"A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.","Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented.""?",False, +18144364,Calcitriol affects diabetic kidney disease,4818,CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.,"Is the triple ""Calcitriol affects diabetic kidney disease"" supported by the sentence: ""CONCLUSIONS: Calcitriol might delay the development of diabetic nephropathy through suppressing inflammation.""?",False, +17907580,Calcitriol affects breast neoplasm,4819,In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.,"Is the triple ""Calcitriol affects breast neoplasm"" supported by the sentence: ""In vivo dual targeting of the oncogenic Ether-a-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.""?",False, +15840384,Calcitriol affects skin basal cell carcinoma,4820,Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.,"Is the triple ""Calcitriol affects skin basal cell carcinoma"" supported by the sentence: ""Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.""?",False, +15206874,Calcitriol affects neoplasm,4821,Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect.""?",False, +15145405,Calcitriol affects neoplasm,4822,Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.,"Is the triple ""Calcitriol affects neoplasm"" supported by the sentence: ""Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.""?",False, +10932246,Calcitriol affects chronic kidney disease,4823,Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.,"Is the triple ""Calcitriol affects chronic kidney disease"" supported by the sentence: ""Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure.""?",False, +9912093,Calcitriol affects prostate cancer,4824,Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.,"Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""Studies continue to define the MTD of calcitriol whichcan be safely administered on this intermittent schedule either alone or with other agents and to evaluate the mechanisms of calcitriol effects in prostate cancer.""?",False, +9912091,Calcitriol affects prostate cancer,4825,"As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.","Is the triple ""Calcitriol affects prostate cancer"" supported by the sentence: ""As a result, phase I and II trials of calcitriol either alone or in combination with the carboplatin, paclitaxel, or dexamethasone have been initiated in patients with androgen-dependent and -independent prostate cancer and advanced cancer.""?",False, +26695789,Calcitriol produces renal osteodystrophy,4826,Renal osteodystrophy may be modulated by extrarenal production of calcitriol.,"Is the triple ""Calcitriol produces renal osteodystrophy"" supported by the sentence: ""Renal osteodystrophy may be modulated by extrarenal production of calcitriol.""?",False, +14288417,Calcitriol produces Crohn disease,4827,"Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).","Is the triple ""Calcitriol produces Crohn disease"" supported by the sentence: ""Compared to HC, TNF-alpha production was significantly higher both in UC (p=0.0002) and CD (p=0.0001) patients, at baseline and after incubation with calcitriol (UC p=0.0003, CD p=0.0009).""?",False, +19013737,Calcitriol disrupts chronic kidney disease,4828,"Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.","Is the triple ""Calcitriol disrupts chronic kidney disease"" supported by the sentence: ""Although the mechanism parathyroid glands sense P remains unknown, the expressions of calcium (Ca) sensing receptor and vitamin D receptor, which sense serum level of Ca and calcitriol respectively, down-regulate in chronic kidney disease.""?",False, +17492128,Calcitriol disrupts prostate cancer,4829,"Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).","Is the triple ""Calcitriol disrupts prostate cancer"" supported by the sentence: ""Calcitriol and QW slowed progression of prostate cancer as indicated by reduced urogenital tract (p = 0.0022, calcitriol; p = 0.0009, QW) and prostate weights (p = 0.0178, calcitriol; p = 0.0086, QW).""?",False, +15711853,Calcitriol disrupts neoplasm,4830,"Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.","Is the triple ""Calcitriol disrupts neoplasm"" supported by the sentence: ""Although the combinations of calcitriol and the AIs caused a statistically significant increase in tumor inhibition in comparison to the single agents, the cooperative interaction between these agents appeared to be minimal at the doses tested.""?",False, +23005720,Calcitriol prevents neoplasm,4831,"We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.","Is the triple ""Calcitriol prevents neoplasm"" supported by the sentence: ""We present evidence that calcitriol (1,25-dihydroxycholecalciferol) decreases tumor takes and tumor growth of subcutaneous retinoblastomas in athymic mice.""?",False, +22688863,Calcitriol prevents Hypocalcemia,4832,"Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.","Is the triple ""Calcitriol prevents Hypocalcemia"" supported by the sentence: ""Collectively, results indicate that treatment with calcitriol at parturition was effective in improving concentrations of iCa, tCa, and tP, which reduced the risk of hypocalcemia.""?",False, +18398383,Calcitriol prevents diabetic kidney disease,4833,OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).,"Is the triple ""Calcitriol prevents diabetic kidney disease"" supported by the sentence: ""OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-beta1) and Cdc42 interacting protein-4 (CIP4).""?",False, +17492127,Calcitriol prevents prostate cancer,4834,"To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)","Is the triple ""Calcitriol prevents prostate cancer"" supported by the sentence: ""To study prevention of androgen-stimulated prostate cancer, vehicle, calcitriol (20 ug/kg), or QW (50 ug/kg) were administered to 4 week-old TRAMP mice intraperitoneal (i.p.)""?",False, +8346486,Calcitriol prevents osteoporosis,4835,Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.,"Is the triple ""Calcitriol prevents osteoporosis"" supported by the sentence: ""Prevention of osteoporosis in heart transplant recipients: a comparison of calcitriol with calcitonin and pamidronate.""?",False, +8053720,Calcitriol prevents postmenopausal osteoporosis,4836,CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.,"Is the triple ""Calcitriol prevents postmenopausal osteoporosis"" supported by the sentence: ""CONCLUSION: We concluded that calcitriol is effective in the prevention of early postmenopausal bone loss in Thais.""?",False, +24886178,Calcitriol exacerbates Sepsis,4837,"Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.","Is the triple ""Calcitriol exacerbates Sepsis"" supported by the sentence: ""Both oral cholecalciferol before and IV calcitriol after CLP promoted cathelicidin secretion, alleviated intestinal inflammation, and ameliorated the epithelial integrity in obese mice complicated with sepsis possibly via VD receptor and AhR signaling pathways.""?",False, +18653087,Calcitriol exacerbates hypertensive disorder,4838,"Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.","Is the triple ""Calcitriol exacerbates hypertensive disorder"" supported by the sentence: ""Chronic anaemia, volume overload, endothelial dysfunction, arterial media calcification, and metabolic derangements like secondary hyperparathyroidism, hyperphosphataemia, and calcitriol deficiency are a few co-morbidities that may cause or worsen HTN in CKD.""?",False, +21373396,Calcitriol predisposes chronic kidney disease,4839,"Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.","Is the triple ""Calcitriol predisposes chronic kidney disease"" supported by the sentence: ""Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha), as well as the mineral biomarkers osteoprotegerin (OPG), osteocalcin (OC), osteopontin (OPN), and fibroblast growth factor 23 (FGF-23), correlate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.""?",False, +17377804,Calcitriol predisposes hypertensive disorder,4840,Calcitriol deficiency is a risk factor for DM and hypertension.,"Is the triple ""Calcitriol predisposes hypertensive disorder"" supported by the sentence: ""Calcitriol deficiency is a risk factor for DM and hypertension.""?",False, +16828204,Calcitriol predisposes osteoporosis,4841,OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.,"Is the triple ""Calcitriol predisposes osteoporosis"" supported by the sentence: ""OBJECTIVE: The aims of this study were to assess changes in muscle mass and strength according to changes in bone mineral density (BMD) after alendronate-calcitriol therapy and to assess subsequent changes in common biomarkers for osteoporosis and sarcopenia to establish a common strategy against these coexisting conditions.""?",False, +9760670,Calcitriol predisposes prostate cancer,4842,"Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.","Is the triple ""Calcitriol predisposes prostate cancer"" supported by the sentence: ""Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer.""?",False, +26462827,Alfacalcidol related to kidney failure,4843,The use of alfacalcidol in the prevention of bone disease in early renal failure.,"Is the triple ""Alfacalcidol related to kidney failure"" supported by the sentence: ""The use of alfacalcidol in the prevention of bone disease in early renal failure.""?",False, +9037270,Alfacalcidol related to postmenopausal osteoporosis,4844,"We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.","Is the triple ""Alfacalcidol related to postmenopausal osteoporosis"" supported by the sentence: ""We evaluated intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis, with special reference to bone mineral density (BMD) and prevention of spinal fracture.""?",False, +7210524,Alfacalcidol related to osteoporosis,4845,"These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.","Is the triple ""Alfacalcidol related to osteoporosis"" supported by the sentence: ""These results suggest that calcitriol, unlike alfacalcidol, may have a clinical therapeutic effect in osteoporosis with hepatic dysfunction.""?",False, +22711685,Alfacalcidol causes osteoporosis,4846,"Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.","Is the triple ""Alfacalcidol causes osteoporosis"" supported by the sentence: ""Registered for use in postmenopausal osteoporosis, in most countries worldwide, alfacalcidol has also shown efficacy in glucocorticoid-induced and male osteoporosis.""?",False, +26635675,Alfacalcidol affects kidney failure,4847,"Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.","Is the triple ""Alfacalcidol affects kidney failure"" supported by the sentence: ""Effects of 24R,25-dihydroxyvitamin D3 in combination with 1 alpha-hydroxyvitamin D3 in predialysis renal insufficiency: biochemistry and histomorphometry of cancellous bone.""?",False, +21927698,Alfacalcidol affects myopathy,4848,This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.,"Is the triple ""Alfacalcidol affects myopathy"" supported by the sentence: ""This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.""?",False, +11900508,Alfacalcidol affects postmenopausal osteoporosis,4849,"The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.","Is the triple ""Alfacalcidol affects postmenopausal osteoporosis"" supported by the sentence: ""The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly.""?",False, +8505855,Alfacalcidol affects osteoporosis,4850,Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.,"Is the triple ""Alfacalcidol affects osteoporosis"" supported by the sentence: ""Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.""?",False, +20641062,Alfacalcidol disrupts osteoporosis,4851,The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.,"Is the triple ""Alfacalcidol disrupts osteoporosis"" supported by the sentence: ""The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined.""?",False, +21927699,Alfacalcidol prevents myopathy,4852,Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.,"Is the triple ""Alfacalcidol prevents myopathy"" supported by the sentence: ""Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.""?",False, +7684744,Alfacalcidol prevents osteoporosis,4853,"There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.","Is the triple ""Alfacalcidol prevents osteoporosis"" supported by the sentence: ""There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.""?",False, +7684734,Alfacalcidol prevents postmenopausal osteoporosis,4854,Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.,"Is the triple ""Alfacalcidol prevents postmenopausal osteoporosis"" supported by the sentence: ""Alfacalcidol prevents rapid postmenopausal bone loss by elimination of Ca malabsorption and by blocking resorbing cytokines.""?",False, +24020567,Cholecalciferol related to male infertility,4855,Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.,"Is the triple ""Cholecalciferol related to male infertility"" supported by the sentence: ""Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study.""?",False, +23185349,Cholecalciferol related to ulcerative colitis,4856,Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.,"Is the triple ""Cholecalciferol related to ulcerative colitis"" supported by the sentence: ""Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis.""?",False, +22584995,Cholecalciferol related to acute myeloid leukemia,4857,"CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.","Is the triple ""Cholecalciferol related to acute myeloid leukemia"" supported by the sentence: ""CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.""?",False, +21514930,Cholecalciferol related to Infection,4858,"Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.","Is the triple ""Cholecalciferol related to Infection"" supported by the sentence: ""Multilocus sequence typing revealed that the strain belongs to the clonal complex CC-21 (ST-44) which is known to be involved in C. jejuni human infections, including outbreaks.""?",False, +21254434,Cholecalciferol related to depressive disorder,4859,"Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.","Is the triple ""Cholecalciferol related to depressive disorder"" supported by the sentence: ""Studies have shown that cholecalciferol supplementation can lead to attenuation of the depressive state; however, the biochemical mechanisms involved in the relationship between cholecalciferol and depression are not very well known.""?",False, +20389616,Cholecalciferol related to anemia,4860,Proportion of anemia increased by trimester among women with colecalciferol deficiency.,"Is the triple ""Cholecalciferol related to anemia"" supported by the sentence: ""Proportion of anemia increased by trimester among women with colecalciferol deficiency.""?",False, +20190699,Cholecalciferol related to autism spectrum disorder,4861,Untangling the most probable role for vitamin D3 in autism.,"Is the triple ""Cholecalciferol related to autism spectrum disorder"" supported by the sentence: ""Untangling the most probable role for vitamin D3 in autism.""?",False, +19639056,Cholecalciferol related to pulmonary tuberculosis,4862,Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.,"Is the triple ""Cholecalciferol related to pulmonary tuberculosis"" supported by the sentence: ""Influence of Cdx2 and TaqI Gene Variants on Vitamin D3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis.""?",False, +18980881,Cholecalciferol related to chronic obstructive pulmonary disease,4863,"These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.","Is the triple ""Cholecalciferol related to chronic obstructive pulmonary disease"" supported by the sentence: ""These results revealed the potent activity of VD3 in inducing differentiation of the Calu-6 cells and the effect of topical administration of VD3 to the lungs to induce lung regeneration at histological and functional levels, demonstrating the potential of VD3 as a curative agent for alveolar destruction in COPD.""?",False, +18889413,Cholecalciferol related to polycystic ovary syndrome,4864,Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?,"Is the triple ""Cholecalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Low vitamin D3 and high anti-Mullerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link?""?",False, +18830431,Cholecalciferol related to prostate cancer,4865,"Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.","Is the triple ""Cholecalciferol related to prostate cancer"" supported by the sentence: ""Attention is paid to the Epimedium plant drug icariin in glioblastoma invasion, the plant Avicennia marina bioactive compound Naphtho[1,2-b]furan-4,5-dione in breast cancer metastasis, the PI3K inhibitor BEZ235 in colon cancer stem cells, the histone methyltransferase EZH1 inhibitor GSK343 in cervical cancer, and vitamin D3 in prostate cancer.""?",False, +18776998,Cholecalciferol related to epilepsy,4866,"These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.","Is the triple ""Cholecalciferol related to epilepsy"" supported by the sentence: ""These findings suggest that the calcium, ionized calcium, and 25-OH vitamin-D3 levels of patients with epilepsy should be regularly assessed.""?",False, +18009382,Cholecalciferol related to type 1 diabetes mellitus,4867,Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.,"Is the triple ""Cholecalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.""?",False, +17581366,Cholecalciferol related to vitamin D deficiency,4868,The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.,"Is the triple ""Cholecalciferol related to vitamin D deficiency"" supported by the sentence: ""The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency.""?",False, +17374616,Cholecalciferol related to type 2 diabetes mellitus,4869,METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.,"Is the triple ""Cholecalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""METHODOLOGY: We measured 25(OH) Vitamin D3 levels in thirty T2DM subjects with thirty age and sex matched healthy controls.""?",False, +17169513,Cholecalciferol related to Parkinson disease,4870,CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.,"Is the triple ""Cholecalciferol related to Parkinson disease"" supported by the sentence: ""CONCLUSIONS: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient.""?",False, +17054911,Cholecalciferol related to tuberculosis,4871,Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.,"Is the triple ""Cholecalciferol related to tuberculosis"" supported by the sentence: ""Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.""?",False, +16909919,Cholecalciferol related to inflammatory bowel disease,4872,Vitamin D3 has been considered a viable adjunctive therapy in IBD.,"Is the triple ""Cholecalciferol related to inflammatory bowel disease"" supported by the sentence: ""Vitamin D3 has been considered a viable adjunctive therapy in IBD.""?",False, +16219443,"Cholecalciferol related to dermatitis, atopic",4873,Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.,"Is the triple ""Cholecalciferol related to dermatitis, atopic"" supported by the sentence: ""Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M.""?",False, +16115730,Cholecalciferol related to cardiovascular disorder,4874,Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.,"Is the triple ""Cholecalciferol related to cardiovascular disorder"" supported by the sentence: ""Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial.""?",False, +15133291,Cholecalciferol related to Marchiafava-Bignami disease,4875,"Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.","Is the triple ""Cholecalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although the roles of UV-B, calcium, phosphorus, and cholecalciferol are better understood in some MBDs, there remain many X factors that are not.""?",False, +14512631,Cholecalciferol related to hyperparathyroidism,4876,Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.,"Is the triple ""Cholecalciferol related to hyperparathyroidism"" supported by the sentence: ""Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.""?",False, +13680137,Cholecalciferol related to multiple sclerosis,4877,"Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.","Is the triple ""Cholecalciferol related to multiple sclerosis"" supported by the sentence: ""Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk.""?",False, +13562951,Cholecalciferol related to metabolic syndrome X,4878,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to metabolic syndrome X"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, +13562949,Cholecalciferol related to obesity disorder,4879,Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.,"Is the triple ""Cholecalciferol related to obesity disorder"" supported by the sentence: ""Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity.""?",False, +13035326,Cholecalciferol related to bone fracture,4880,Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.,"Is the triple ""Cholecalciferol related to bone fracture"" supported by the sentence: ""Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.""?",False, +11935565,Cholecalciferol related to osteoporosis,4881,"The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.","Is the triple ""Cholecalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D3 in osteoporosis is conclusively established from a very simple meta-analysis of the four randomized, placebo-controlled clinical trials into the effect of 20 microg (800 IU) per day.""?",False, +11152529,Cholecalciferol related to diabetes mellitus,4882,"Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.","Is the triple ""Cholecalciferol related to diabetes mellitus"" supported by the sentence: ""Diabetes incidence was neither reduced by fish-oil or vitamin D3 supplementation alone, nor in mice fed a wheat and barley protein-free diet that was supplemented with fish-oil and vitamin D3.""?",False, +10386853,Cholecalciferol related to Crohn disease,4883,OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.,"Is the triple ""Cholecalciferol related to Crohn disease"" supported by the sentence: ""OBJECTIVE: To determine the frequency of low serum 25-hydroxy-vitamin D3 (25-OHD) levels and the associated alterations in bone mineral density in a cohort of adults with Crohn's disease.""?",False, +9703967,Cholecalciferol related to melanoma,4884,"As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.","Is the triple ""Cholecalciferol related to melanoma"" supported by the sentence: ""As in other cancers, there is evidence of a protective effect of vitamin D3 in MM, but ultraviolet radiation, which is a principal source of vitamin D3, is mutagenic.""?",False, +9414232,Cholecalciferol related to psoriasis,4885,Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.,"Is the triple ""Cholecalciferol related to psoriasis"" supported by the sentence: ""Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.""?",False, +8798994,Cholecalciferol related to hip fracture,4886,"Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.","Is the triple ""Cholecalciferol related to hip fracture"" supported by the sentence: ""Administration of vitamin D3 alone without calcium co-supplementation was not associated with any reduction in incidence of hip fracture (relative risk (RR) 1.20, 95% confidence interval (CI) 0.83, 1.75) or other non-vertebral fracture.""?",False, +20878953,Cholecalciferol causes polycystic ovary syndrome,4887,"Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.","Is the triple ""Cholecalciferol causes polycystic ovary syndrome"" supported by the sentence: ""Leptin and Vitamin D3 may have a role in the pathogenesis of lean PCOS, but large studies are still required regarding this unique group.""?",False, +20469671,Cholecalciferol causes tuberculosis,4888,Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.,"Is the triple ""Cholecalciferol causes tuberculosis"" supported by the sentence: ""Incubation of monocytes with three cholecalciferol metabolites induced anti-tuberculosis activity to an extent that correlated with their binding affinities to the intracellular receptor protein for the derivatives.""?",False, +20417553,Cholecalciferol causes psoriasis,4889,There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.,"Is the triple ""Cholecalciferol causes psoriasis"" supported by the sentence: ""There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis.""?",False, +19411734,"Cholecalciferol causes dermatitis, atopic",4890,"In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.","Is the triple ""Cholecalciferol causes dermatitis, atopic"" supported by the sentence: ""In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice.""?",False, +17854537,Cholecalciferol causes neoplasm,4891,"Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.","Is the triple ""Cholecalciferol causes neoplasm"" supported by the sentence: ""Since DeltaNp63alpha has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development.""?",False, +15944158,Cholecalciferol causes vitamin D deficiency,4892,"Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.","Is the triple ""Cholecalciferol causes vitamin D deficiency"" supported by the sentence: ""Along with aging, the synthesis of vitamin D3 in the skin declines with insufficient sunlight exposure, leading to vitamin D deficiency.""?",False, +13998286,Cholecalciferol causes depressive disorder,4893,"Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.","Is the triple ""Cholecalciferol causes depressive disorder"" supported by the sentence: ""Thus 1-25 Dihydroxycholecalciferol, the active form of vitamin D3 is not formed, resulting in depression of intestinal calcium absorption and reabsorption from the bones.""?",False, +27560876,Cholecalciferol affects prostate cancer,4894,Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.,"Is the triple ""Cholecalciferol affects prostate cancer"" supported by the sentence: ""Simultaneous administration of a potent vitamin D3 analog and receptor-selective retinoids may have therapeutic potential for the treatment of androgen-dependent and -independent prostate cancer.""?",False, +22640117,Cholecalciferol affects severe acute respiratory syndrome,4895,Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?,"Is the triple ""Cholecalciferol affects severe acute respiratory syndrome"" supported by the sentence: ""Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable?""?",False, +21843529,Cholecalciferol affects Pregnancy,4896,"Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""Serum levels of 1 alpha,25-(OH)2 vitamin D3 (D3) increased late in pregnancy, however, those of parathyroid hormone (PTH) increased not significantly throughout pregnancy.""?",False, +21703950,Cholecalciferol affects Marchiafava-Bignami disease,4897,"VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.","Is the triple ""Cholecalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""VK2 supplementation in dose of 90 ug/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D 3 brought no additional effects.""?",False, +20945952,Cholecalciferol affects type 2 diabetes mellitus,4898,Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.,"Is the triple ""Cholecalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM.""?",False, +20733345,Cholecalciferol affects epilepsy,4899,"Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.","Is the triple ""Cholecalciferol affects epilepsy"" supported by the sentence: ""Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice.""?",False, +20612106,Cholecalciferol affects Cognitive impairment,4900,Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.,"Is the triple ""Cholecalciferol affects Cognitive impairment"" supported by the sentence: ""Vitamin D3 as a potentially modifiable factor in mild cognitive impairment.""?",False, +19925618,Cholecalciferol affects asthma,4901,"METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.","Is the triple ""Cholecalciferol affects asthma"" supported by the sentence: ""METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016.""?",False, +19815601,Cholecalciferol affects ulcerative colitis,4902,The effect of vitamin D3 on UC disease activity is still unclear.,"Is the triple ""Cholecalciferol affects ulcerative colitis"" supported by the sentence: ""The effect of vitamin D3 on UC disease activity is still unclear.""?",False, +19556148,Cholecalciferol affects neoplasm,4903,"In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""In conclusion, TQ augmented the chemopreventive effect of Vit.D during the initiation phase of colon cancer in rat model, with the potential to suppress progression of pre-neoplastic lesions in colon carcinogenesis.""?",False, +19132727,Cholecalciferol affects obesity disorder,4904,Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.,"Is the triple ""Cholecalciferol affects obesity disorder"" supported by the sentence: ""Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.""?",False, +18122364,Cholecalciferol affects metabolic syndrome X,4905,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects metabolic syndrome X"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, +18122363,Cholecalciferol affects cardiovascular disorder,4906,Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.,"Is the triple ""Cholecalciferol affects cardiovascular disorder"" supported by the sentence: ""Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.""?",False, +17715748,Cholecalciferol affects hip fracture,4907,"Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.","Is the triple ""Cholecalciferol affects hip fracture"" supported by the sentence: ""Therefore, we assessed the budgetary impact of routine prescription of 800 IU daily colecalciferol on hip fracture among older adults in the United Kingdom.""?",False, +17674517,Cholecalciferol affects Pregnancy,4908,"OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.","Is the triple ""Cholecalciferol affects Pregnancy"" supported by the sentence: ""OUTCOME MEASURES: ECFC tubule formation (Matrigel assay) and migration were examined in the presence of either maternal serum from preeclampsia cases or uncomplicated pregnancy controls, or pooled CM, in the presence or absence of 1,25(OH)2 vitamin D3.""?",False, +17585577,Cholecalciferol affects depressive disorder,4909,"It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.","Is the triple ""Cholecalciferol affects depressive disorder"" supported by the sentence: ""It is currently unknown whether the biologically active form of vitamin D, that is, 1,25-(OH)2 vitamin D3, is also decreased in late-life depression, or whether vitamin D levels correlate with specific depression characteristics.""?",False, +17451551,Cholecalciferol affects neoplasm,4910,"Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.","Is the triple ""Cholecalciferol affects neoplasm"" supported by the sentence: ""Vitamin D derivatives, including its physiological form 1alpha,25(OH)2 vitamin D3 (1,25D), have anti-tumor actions demonstrated in cell culture and confirmatory epidemiological associations are frequently reported.""?",False, +16299943,Cholecalciferol affects polycystic ovary syndrome,4911,"The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).","Is the triple ""Cholecalciferol affects polycystic ovary syndrome"" supported by the sentence: ""The aim of this study was to clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on pharmacological reactivity of a resistance vessel in a rat model and the possible modulatory role of 1,25-(OH)2-cholecalciferol (vitamin D3).""?",False, +16007821,Cholecalciferol affects psoriasis,4912,Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.,"Is the triple ""Cholecalciferol affects psoriasis"" supported by the sentence: ""Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis.""?",False, +15977971,Cholecalciferol affects melanoma,4913,"CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.","Is the triple ""Cholecalciferol affects melanoma"" supported by the sentence: ""CONCLUSION: Classical 1,25(OH)(2)D(3) and novel 20(OH)D(3) hydroxyderivatives of vitamin D3 can target NF-kappaB and regulate melanoma progression in nonpigmented melanoma cells.""?",False, +15944152,Cholecalciferol affects osteoporosis,4914,[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].,"Is the triple ""Cholecalciferol affects osteoporosis"" supported by the sentence: ""[Frontiers in vitamin D; basic Research and clinical application. Effect of active vitamin D3 on osteoporosis].""?",False, +15393278,Cholecalciferol affects chronic obstructive pulmonary disease,4915,"Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.","Is the triple ""Cholecalciferol affects chronic obstructive pulmonary disease"" supported by the sentence: ""Preliminary studies and suggest that supplementation with omega-3 polyunsaturated fatty acids and micronutrient repletion with Vitamin A, Vitamin D3, and zinc may have beneficial effects in COPD.""?",False, +15170889,Cholecalciferol affects multiple sclerosis,4916,The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.,"Is the triple ""Cholecalciferol affects multiple sclerosis"" supported by the sentence: ""The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.""?",False, +13518388,Cholecalciferol affects bone fracture,4917,[Latest evidence on the suppressive effect of active vitamin D3 on fractures].,"Is the triple ""Cholecalciferol affects bone fracture"" supported by the sentence: ""[Latest evidence on the suppressive effect of active vitamin D3 on fractures].""?",False, +21045274,Cholecalciferol produces Marchiafava-Bignami disease,4918,"CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.","Is the triple ""Cholecalciferol produces Marchiafava-Bignami disease"" supported by the sentence: ""CONCLUSION: According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.""?",False, +17840044,Cholecalciferol produces inflammatory bowel disease,4919,"The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.","Is the triple ""Cholecalciferol produces inflammatory bowel disease"" supported by the sentence: ""The studies reveal that, among others things, inflammatory bowel diseases occur in higher latitudes, with lower exposure to solar radiation and with decreased production of vitamin D3 in the skin.""?",False, +20733344,Cholecalciferol disrupts epilepsy,4920,Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.,"Is the triple ""Cholecalciferol disrupts epilepsy"" supported by the sentence: ""Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice.""?",False, +19044664,Cholecalciferol disrupts AIDS,4921,Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.,"Is the triple ""Cholecalciferol disrupts AIDS"" supported by the sentence: ""Vitamin D3 inhibits TNFalpha-induced latent HIV reactivation in J-LAT cells.""?",False, +15558469,Cholecalciferol disrupts HIV infectious disease,4922,"Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.","Is the triple ""Cholecalciferol disrupts HIV infectious disease"" supported by the sentence: ""Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.""?",False, +14834931,Cholecalciferol disrupts neoplasm,4923,"Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.","Is the triple ""Cholecalciferol disrupts neoplasm"" supported by the sentence: ""Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation.""?",False, +14617748,Cholecalciferol disrupts multiple sclerosis,4924,"Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.","Is the triple ""Cholecalciferol disrupts multiple sclerosis"" supported by the sentence: ""Because vitamin D3 is an inhibitor of MS, providing supplemental D3 for individuals at risk for MS should be mandatory.""?",False, +14491908,Cholecalciferol disrupts vitamin D deficiency,4925,"Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.","Is the triple ""Cholecalciferol disrupts vitamin D deficiency"" supported by the sentence: ""Three-monthly administration of the moderate dosage of 100,000 IU of vitamin D3 all year round would offer a simple, effective and risk-free system to counteract vitamin D deficiency in the elderly and of preventing the risk of osteomalacia, thus reducing the incidence of fractures.""?",False, +11194374,Cholecalciferol disrupts Marchiafava-Bignami disease,4926,Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.,"Is the triple ""Cholecalciferol disrupts Marchiafava-Bignami disease"" supported by the sentence: ""Animal and basic research studies showed that active vitamin D3 analogues can inhibit bone loss during treatment with glucocorticoids.""?",False, +25419746,Cholecalciferol prevents Infection,4927,This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.,"Is the triple ""Cholecalciferol prevents Infection"" supported by the sentence: ""This is supported by published studies that metformin and vitamin D3 could reduce the severity of both COVID-19 and early post-primary TB infections.""?",False, +23552226,Cholecalciferol prevents type 1 diabetes mellitus,4928,Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?,"Is the triple ""Cholecalciferol prevents type 1 diabetes mellitus"" supported by the sentence: ""Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?""?",False, +23324302,Cholecalciferol prevents ulcerative colitis,4929,CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.,"Is the triple ""Cholecalciferol prevents ulcerative colitis"" supported by the sentence: ""CONCLUSIONS: We found that vitamin C combined with vitamin D 3 protected against dextran sodium sulfate-induced ulcerative colitis in the guinea pig intestinal mucosa.""?",False, +22418643,Cholecalciferol prevents chronic obstructive pulmonary disease,4930,"MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).","Is the triple ""Cholecalciferol prevents chronic obstructive pulmonary disease"" supported by the sentence: ""MR analysis suggested a protective causal effect of increased serum CC-16 on COPD risk (MR estimate (SE) -0.11 (0.04), p=0.008) and progression (LHS only, MR estimate (SE) 7.40 (3.28), p=0.02).""?",False, +22340834,Cholecalciferol prevents depressive disorder,4931,These findings do not support the use of vitamin D3 in adults to prevent depression.,"Is the triple ""Cholecalciferol prevents depressive disorder"" supported by the sentence: ""These findings do not support the use of vitamin D3 in adults to prevent depression.""?",False, +20959064,Cholecalciferol prevents postmenopausal osteoporosis,4932,"Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?","Is the triple ""Cholecalciferol prevents postmenopausal osteoporosis"" supported by the sentence: ""Does 24R,25(OH)2-vitamin D3 prevent postmenopausal bone loss?""?",False, +20699168,Cholecalciferol prevents cardiovascular disorder,4933,"Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.","Is the triple ""Cholecalciferol prevents cardiovascular disorder"" supported by the sentence: ""Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: A randomized, placebo-controlled clinical trial.""?",False, +19389521,Cholecalciferol prevents epilepsy,4934,"Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.","Is the triple ""Cholecalciferol prevents epilepsy"" supported by the sentence: ""Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy.""?",False, +18282049,Cholecalciferol prevents inherited lipid metabolism disorder,4935,"Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.","Is the triple ""Cholecalciferol prevents inherited lipid metabolism disorder"" supported by the sentence: ""Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats.""?",False, +17951280,Cholecalciferol prevents anemia,4936,VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.,"Is the triple ""Cholecalciferol prevents anemia"" supported by the sentence: ""VitD prevented the development of anaemia and significantly increased the concentrations of EPO at serum and kidney levels in the 'RD' and 'PRD' groups compared to 'R' and 'PR' groups.""?",False, +17701830,Cholecalciferol prevents influenza,4937,[Does vitamin D3 fail to protect against influenza after all?].,"Is the triple ""Cholecalciferol prevents influenza"" supported by the sentence: ""[Does vitamin D3 fail to protect against influenza after all?].""?",False, +15773595,Cholecalciferol prevents neoplasm,4938,[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].,"Is the triple ""Cholecalciferol prevents neoplasm"" supported by the sentence: ""[A role for calcium and vitamin D3 in the prevention of colo-rectal tumors].""?",False, +15663430,Cholecalciferol prevents diabetes mellitus,4939,"There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.","Is the triple ""Cholecalciferol prevents diabetes mellitus"" supported by the sentence: ""There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.""?",False, +12943427,Cholecalciferol prevents vitamin D deficiency,4940,"The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.","Is the triple ""Cholecalciferol prevents vitamin D deficiency"" supported by the sentence: ""The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences, ensuing illness, especially, bone fractures in the elderly.""?",False, +11194373,Cholecalciferol prevents osteoporosis,4941,"The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.","Is the triple ""Cholecalciferol prevents osteoporosis"" supported by the sentence: ""The aim of this review with meta-analysis was to determine if there is a rationale to use activated forms of vitamin D3 to treat or prevent glucocorticoid-induced osteoporosis, and to compare the effect of active vitamin D3 metabolites with that of other anti-osteoporosis therapies.""?",False, +11017561,Cholecalciferol prevents Marchiafava-Bignami disease,4942,Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.,"Is the triple ""Cholecalciferol prevents Marchiafava-Bignami disease"" supported by the sentence: ""Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3.""?",False, +10503621,Cholecalciferol prevents bone fracture,4943,CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.,"Is the triple ""Cholecalciferol prevents bone fracture"" supported by the sentence: ""CONCLUSIONS: Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.""?",False, +9458588,Cholecalciferol prevents hip fracture,4944,We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.,"Is the triple ""Cholecalciferol prevents hip fracture"" supported by the sentence: ""We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial.""?",False, +21072124,Cholecalciferol predisposes metabolic syndrome X,4945,"Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.","Is the triple ""Cholecalciferol predisposes metabolic syndrome X"" supported by the sentence: ""Conclusions: In postmenopausal women with VD deficiency, isolated supplementation with 1000 IU vitamin D3 for 9 months was associated with a reduction in the MetS risk profile.""?",False, +18104348,Cholecalciferol predisposes colorectal neoplasm,4946,These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.,"Is the triple ""Cholecalciferol predisposes colorectal neoplasm"" supported by the sentence: ""These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.""?",False, +17901013,Cholecalciferol predisposes bone fracture,4947,"Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.","Is the triple ""Cholecalciferol predisposes bone fracture"" supported by the sentence: ""Toxicity in the long term cannot be excluded as annual doses of 500,000 IU of vitamin D3 for several years have shown an increase in the risk of fractures.""?",False, +17714481,Cholecalciferol predisposes asthma,4948,"Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.","Is the triple ""Cholecalciferol predisposes asthma"" supported by the sentence: ""Two studies found that low serum vitamin D level is associated with an increased risk of developing asthma late in childhood, while the third study found no association with either vitamin D2 or vitamin D3 levels.""?",False, +17184810,Cholecalciferol predisposes multiple sclerosis,4949,"There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.","Is the triple ""Cholecalciferol predisposes multiple sclerosis"" supported by the sentence: ""There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in the brain.""?",False, +15110409,Cholecalciferol predisposes vitamin D deficiency,4950,Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.,"Is the triple ""Cholecalciferol predisposes vitamin D deficiency"" supported by the sentence: ""Increased rate of metabolism of cholecalciferol and deficient production of 25 ohd contribute to vitamin D deficiency in liver disease.""?",False, +13562954,Cholecalciferol predisposes type 2 diabetes mellitus,4951,"In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.","Is the triple ""Cholecalciferol predisposes type 2 diabetes mellitus"" supported by the sentence: ""In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se.""?",False, +9524358,Cholecalciferol predisposes hip fracture,4952,"Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.","Is the triple ""Cholecalciferol predisposes hip fracture"" supported by the sentence: ""Thus, these data are in agreement with those of Decalyos I and indicate that calcium and vitamin D3 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.""?",False, +9314384,Cholecalciferol predisposes Marchiafava-Bignami disease,4953,"Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.","Is the triple ""Cholecalciferol predisposes Marchiafava-Bignami disease"" supported by the sentence: ""Advanced liver disease is associated with increased bone loss, and hyperbilirubinaemia and low levels of vitamin D3 are predictors of increased bone loss.""?",False, +27330803,Ergocalciferol related to Familial hypophosphatemia,4954,Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.,"Is the triple ""Ergocalciferol related to Familial hypophosphatemia"" supported by the sentence: ""Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice.""?",False, +26089502,Ergocalciferol related to osteogenesis imperfecta,4955,Vitamin D and related research in osteogenesis imperfecta.,"Is the triple ""Ergocalciferol related to osteogenesis imperfecta"" supported by the sentence: ""Vitamin D and related research in osteogenesis imperfecta.""?",False, +22199149,Ergocalciferol related to Hypocalcemia,4956,Hypocalcemia may be associated with imbalanced VD and PTH levels.,"Is the triple ""Ergocalciferol related to Hypocalcemia"" supported by the sentence: ""Hypocalcemia may be associated with imbalanced VD and PTH levels.""?",False, +22194600,Ergocalciferol related to severe acute respiratory syndrome,4957,"Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.","Is the triple ""Ergocalciferol related to severe acute respiratory syndrome"" supported by the sentence: ""Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.""?",False, +21840711,Ergocalciferol related to castration-resistant prostate carcinoma,4958,"Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.","Is the triple ""Ergocalciferol related to castration-resistant prostate carcinoma"" supported by the sentence: ""Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials.In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed.""?",False, +21543726,Ergocalciferol related to sarcopenia,4959,"Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.","Is the triple ""Ergocalciferol related to sarcopenia"" supported by the sentence: ""Relationship between serum vitamin D level and sarcopenia in chronic liver disease.AIM: Although the association of vitamin D with primary sarcopenia has been extensively investigated, its relationship with secondary sarcopenia in patients with liver disease remains unclear.""?",False, +21516783,Ergocalciferol related to non-alcoholic fatty liver disease,4960,"Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.","Is the triple ""Ergocalciferol related to non-alcoholic fatty liver disease"" supported by the sentence: ""Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in Korean older adults.The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels.""?",False, +21478252,Ergocalciferol related to bone fracture,4961,"Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.","Is the triple ""Ergocalciferol related to bone fracture"" supported by the sentence: ""Impact of insufficient admission vitamin D serum concentrations on sepsis incidence and clinical outcomes in patients with thermal injury.INTRODUCTION: In burn patients, vitamin D has been studied primarily in the pediatric population and focused mainly on the correlation with bone marker measurements and incidence of fractures.""?",False, +21128214,Ergocalciferol related to bone Paget disease,4962,Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.,"Is the triple ""Ergocalciferol related to bone Paget disease"" supported by the sentence: ""Vitamin D Status in Paget Disease of Bone and Efficacy-Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D.""?",False, +20256197,Ergocalciferol related to restless legs syndrome,4963,"After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).","Is the triple ""Ergocalciferol related to restless legs syndrome"" supported by the sentence: ""After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).""?",False, +19853448,Ergocalciferol related to neuralgia,4964,This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.,"Is the triple ""Ergocalciferol related to neuralgia"" supported by the sentence: ""This study aimed to examine the development of NP in patients with RA and the relationship between NP and vitamin D.""?",False, +19595978,Ergocalciferol related to hepatitis C virus infection,4965,BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.,"Is the triple ""Ergocalciferol related to hepatitis C virus infection"" supported by the sentence: ""BACKGROUND AND AIM: The impact of 25-OH vitamin D on sustained viral response (SVR) to antiviral therapy and on fibrosis progression in hepatitis C is debated.""?",False, +19221334,Ergocalciferol related to spinal cord injury,4966,"Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.","Is the triple ""Ergocalciferol related to spinal cord injury"" supported by the sentence: ""Although there are several biological plausible mechanisms by which vitamin D may act upon musculoskeletal and cardiometabolic health, the impact of vitamin D insufficiency on such systems remains ill defined in SCI.""?",False, +18303138,Ergocalciferol related to optic neuritis,4967,"The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.","Is the triple ""Ergocalciferol related to optic neuritis"" supported by the sentence: ""The study indicates a possible role of vitamin D in the early stages of MS, but does not support the use of 25HVITDL as a predictor of MS development in acute ON.""?",False, +17457750,Ergocalciferol related to migraine disorder,4968,"CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.","Is the triple ""Ergocalciferol related to migraine disorder"" supported by the sentence: ""CONCLUSIONS: We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level.""?",False, +17248671,Ergocalciferol related to diffuse alopecia areata,4969,"There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.","Is the triple ""Ergocalciferol related to diffuse alopecia areata"" supported by the sentence: ""There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms.""?",False, +16231683,Ergocalciferol related to chronic hepatitis C virus infection,4970,Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.,"Is the triple ""Ergocalciferol related to chronic hepatitis C virus infection"" supported by the sentence: ""Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.""?",False, +16050991,Ergocalciferol related to lung neoplasm,4971,"In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.","Is the triple ""Ergocalciferol related to lung neoplasm"" supported by the sentence: ""In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.""?",False, +15954794,Ergocalciferol related to femoral neck fracture,4972,Spontaneous femoral neck fracture associated with a low serum level of vitamin D.,"Is the triple ""Ergocalciferol related to femoral neck fracture"" supported by the sentence: ""Spontaneous femoral neck fracture associated with a low serum level of vitamin D.""?",False, +15739454,Ergocalciferol related to diabetic neuropathy,4973,Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.,"Is the triple ""Ergocalciferol related to diabetic neuropathy"" supported by the sentence: ""Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES.""?",False, +15603622,Ergocalciferol related to HIV infectious disease,4974,Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.,"Is the triple ""Ergocalciferol related to HIV infectious disease"" supported by the sentence: ""Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study.""?",False, +15306422,Ergocalciferol related to blood coagulation disease,4975,"Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.","Is the triple ""Ergocalciferol related to blood coagulation disease"" supported by the sentence: ""Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia.""?",False, +15165807,Ergocalciferol related to postmenopausal osteoporosis,4976,Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.,"Is the triple ""Ergocalciferol related to postmenopausal osteoporosis"" supported by the sentence: ""Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis.""?",False, +14949967,Ergocalciferol related to Premature birth,4977,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to Premature birth"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, +14949966,Ergocalciferol related to gestational diabetes,4978,"Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.","Is the triple ""Ergocalciferol related to gestational diabetes"" supported by the sentence: ""Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women.""?",False, +14870236,Ergocalciferol related to chronic renal failure syndrome,4979,[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].,"Is the triple ""Ergocalciferol related to chronic renal failure syndrome"" supported by the sentence: ""[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].""?",False, +14594285,Ergocalciferol related to colorectal neoplasm,4980,"Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.","Is the triple ""Ergocalciferol related to colorectal neoplasm"" supported by the sentence: ""Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia.""?",False, +14321159,Ergocalciferol related to asthma,4981,"Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.","Is the triple ""Ergocalciferol related to asthma"" supported by the sentence: ""Because vitamin D deficiency is prevalent even in sun-replete areas, clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.""?",False, +13975664,Ergocalciferol related to cutaneous lupus erythematosus,4982,Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.,"Is the triple ""Ergocalciferol related to cutaneous lupus erythematosus"" supported by the sentence: ""Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.""?",False, +13939480,Ergocalciferol related to mood disorder,4983,This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.,"Is the triple ""Ergocalciferol related to mood disorder"" supported by the sentence: ""This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted.""?",False, +13895667,Ergocalciferol related to sudden cardiac arrest,4984,OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).,"Is the triple ""Ergocalciferol related to sudden cardiac arrest"" supported by the sentence: ""OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).""?",False, +13383363,Ergocalciferol related to sickle cell anemia,4985,The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.,"Is the triple ""Ergocalciferol related to sickle cell anemia"" supported by the sentence: ""The role of vitamin D and calcium supplementation to restore bone health in SCD has not been well studied.""?",False, +13199782,Ergocalciferol related to Alzheimer disease,4986,"Consequently, this study provides evidence for a possible link between AD and vitamin D.","Is the triple ""Ergocalciferol related to Alzheimer disease"" supported by the sentence: ""Consequently, this study provides evidence for a possible link between AD and vitamin D.""?",False, +12834035,Ergocalciferol related to inflammatory bowel disease,4987,Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.,"Is the triple ""Ergocalciferol related to inflammatory bowel disease"" supported by the sentence: ""Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.""?",False, +12803681,Ergocalciferol related to Insulin resistance,4988,We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.,"Is the triple ""Ergocalciferol related to Insulin resistance"" supported by the sentence: ""We conclude that 25-hydroxyvitamin D deficiency is not as prevalent in the US general population with decreased eGFR as previously reported in patients with CKD; and that vitamin D and kidney function have independent inverse associations with IR.""?",False, +12377378,Ergocalciferol related to non-Hodgkin lymphoma,4989,CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.,"Is the triple ""Ergocalciferol related to non-Hodgkin lymphoma"" supported by the sentence: ""CONCLUSIONS: Our study suggests that a diet rich in polyunsaturated fatty acids and vitamin D is associated with a reduced risk of NHL.""?",False, +12131992,Ergocalciferol related to primary hyperparathyroidism,4990,"Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.","Is the triple ""Ergocalciferol related to primary hyperparathyroidism"" supported by the sentence: ""Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.""?",False, +11979233,Ergocalciferol related to leukemia,4991,Vitamin D compounds in leukemia.,"Is the triple ""Ergocalciferol related to leukemia"" supported by the sentence: ""Vitamin D compounds in leukemia.""?",False, +11933002,Ergocalciferol related to Pain,4992,"CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.","Is the triple ""Ergocalciferol related to Pain"" supported by the sentence: ""CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation.""?",False, +11653558,Ergocalciferol related to melanoma,4993,The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.,"Is the triple ""Ergocalciferol related to melanoma"" supported by the sentence: ""The present investigation tests this theory by examining the relation between dietary vitamin D and melanoma risk in a case-control study.""?",False, +11434397,Ergocalciferol related to type 1 diabetes mellitus,4994,"Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.","Is the triple ""Ergocalciferol related to type 1 diabetes mellitus"" supported by the sentence: ""Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes.""?",False, +11002964,Ergocalciferol related to pulmonary tuberculosis,4995,[Effect of vitamin D2 in pulmonary tuberculosis].,"Is the triple ""Ergocalciferol related to pulmonary tuberculosis"" supported by the sentence: ""[Effect of vitamin D2 in pulmonary tuberculosis].""?",False, +10894479,Ergocalciferol related to Crohn disease,4996,"A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.","Is the triple ""Ergocalciferol related to Crohn disease"" supported by the sentence: ""A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.""?",False, +10768947,Ergocalciferol related to hip fracture,4997,BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.,"Is the triple ""Ergocalciferol related to hip fracture"" supported by the sentence: ""BACKGROUND: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates.""?",False, +10183383,Ergocalciferol related to Marchiafava-Bignami disease,4998,"Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.","Is the triple ""Ergocalciferol related to Marchiafava-Bignami disease"" supported by the sentence: ""Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause.""?",False, +10168534,Ergocalciferol related to tuberculosis,4999,"Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.","Is the triple ""Ergocalciferol related to tuberculosis"" supported by the sentence: ""Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer.""?",False, +10066878,Ergocalciferol related to lymphoma,5000,"However, the cellular source of the vitamin D hormone in lymphomas remains unclear.","Is the triple ""Ergocalciferol related to lymphoma"" supported by the sentence: ""However, the cellular source of the vitamin D hormone in lymphomas remains unclear.""?",False, +9770434,Ergocalciferol related to neoplasm,1,"On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.","Is the triple ""Ergocalciferol related to neoplasm"" supported by the sentence: ""On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results.""?",False, +9499640,Ergocalciferol related to hypoparathyroidism,2,The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.,"Is the triple ""Ergocalciferol related to hypoparathyroidism"" supported by the sentence: ""The increased relative effectiveness of these one-hydroxylated forms of vitamin D reveals a deficiency of vitamin D one-hydroxylation in hypoparathyroidism.""?",False, +9487308,Ergocalciferol related to myocardial ischemia,3,Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).,"Is the triple ""Ergocalciferol related to myocardial ischemia"" supported by the sentence: ""Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD).""?",False, +9462983,Ergocalciferol related to ulcerative colitis,4,Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.,"Is the triple ""Ergocalciferol related to ulcerative colitis"" supported by the sentence: ""Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.""?",False, +9176947,Ergocalciferol related to psoriasis,5,[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].,"Is the triple ""Ergocalciferol related to psoriasis"" supported by the sentence: ""[Therapeutic effects of vitamin D and vitamin A in psoriasis (a 20-year experiment)].""?",False, +9137351,Ergocalciferol related to nutritional disorder,6,"RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.","Is the triple ""Ergocalciferol related to nutritional disorder"" supported by the sentence: ""RESULTS AND CONCLUSIONS: Regular high-impact physical exercise, a daily allowance of at least 1000 mg calcium, a sufficient supplementation with vitamin D through UVB-exposure of the skin or oral supplementation, and hormonal replacement therapy in deficiency states are the fundamentals of prevention of osteoporosis.""?",False, +8792180,Ergocalciferol related to type 2 diabetes mellitus,7,Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.,"Is the triple ""Ergocalciferol related to type 2 diabetes mellitus"" supported by the sentence: ""Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.""?",False, +8116213,Ergocalciferol related to obesity disorder,8,These data suggest that low vitamin D may be associated with obesity per se.,"Is the triple ""Ergocalciferol related to obesity disorder"" supported by the sentence: ""These data suggest that low vitamin D may be associated with obesity per se.""?",False, +8093753,Ergocalciferol related to vitamin D deficiency,9,The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.,"Is the triple ""Ergocalciferol related to vitamin D deficiency"" supported by the sentence: ""The present study was conducted to delineate the roles of vitamin D and calcium in glucose intolerance associated with vitamin D deficiency in vivo.""?",False, +8061037,Ergocalciferol related to multiple sclerosis,10,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to multiple sclerosis"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, +8061036,Ergocalciferol related to diabetes mellitus,11,"Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.","Is the triple ""Ergocalciferol related to diabetes mellitus"" supported by the sentence: ""Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes.""?",False, +7613246,Ergocalciferol related to osteoporosis,12,The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.,"Is the triple ""Ergocalciferol related to osteoporosis"" supported by the sentence: ""The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach.""?",False, +7587226,Ergocalciferol related to polycystic ovary syndrome,13,Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.,"Is the triple ""Ergocalciferol related to polycystic ovary syndrome"" supported by the sentence: ""Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.""?",False, +7252642,Ergocalciferol related to prostate cancer,14,"Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.","Is the triple ""Ergocalciferol related to prostate cancer"" supported by the sentence: ""Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.""?",False, +26403196,Ergocalciferol causes primary hyperparathyroidism,15,Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.,"Is the triple ""Ergocalciferol causes primary hyperparathyroidism"" supported by the sentence: ""Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D.""?",False, +25624374,Ergocalciferol causes leukemia,16,Reversibility of vitamin D-induced human leukemia cell-line maturation.,"Is the triple ""Ergocalciferol causes leukemia"" supported by the sentence: ""Reversibility of vitamin D-induced human leukemia cell-line maturation.""?",False, +25513025,Ergocalciferol causes restless legs syndrome,17,We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.,"Is the triple ""Ergocalciferol causes restless legs syndrome"" supported by the sentence: ""We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS.""?",False, +25147512,Ergocalciferol causes sarcopenia,18,"To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.","Is the triple ""Ergocalciferol causes sarcopenia"" supported by the sentence: ""To counteract sarcopenia, intake of protein is an important factor, while a lack of either protein or vitamin D is a major cause of sarcopenia.""?",False, +21420546,Ergocalciferol causes diabetic neuropathy,19,"Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).","Is the triple ""Ergocalciferol causes diabetic neuropathy"" supported by the sentence: ""Vitamin D plays an important role in the pathogenesis of DN, thus affecting its severity which can be assessed using nerve conduction study (NCS).""?",False, +21344725,Ergocalciferol causes diffuse alopecia areata,20,"This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.","Is the triple ""Ergocalciferol causes diffuse alopecia areata"" supported by the sentence: ""This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA.""?",False, +19221130,Ergocalciferol causes non-alcoholic fatty liver disease,21,"Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.","Is the triple ""Ergocalciferol causes non-alcoholic fatty liver disease"" supported by the sentence: ""Hence, despite preclinical evidence implicating VitD in NAFLD pathogenesis, VitD deficiency does not appear to be associated with NAFLD severity in humans.""?",False, +19022139,Ergocalciferol causes gestational diabetes,22,BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).,"Is the triple ""Ergocalciferol causes gestational diabetes"" supported by the sentence: ""BACKGROUND/OBJECTIVES: Vitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM).""?",False, +18967408,Ergocalciferol causes polycystic ovary syndrome,23,"BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.","Is the triple ""Ergocalciferol causes polycystic ovary syndrome"" supported by the sentence: ""BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.""?",False, +18875338,Ergocalciferol causes psoriasis,24,"The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.","Is the triple ""Ergocalciferol causes psoriasis"" supported by the sentence: ""The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.""?",False, +18041148,Ergocalciferol causes Crohn disease,25,"Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.","Is the triple ""Ergocalciferol causes Crohn disease"" supported by the sentence: ""Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention.""?",False, +16369420,Ergocalciferol causes neoplasm,26,"Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.","Is the triple ""Ergocalciferol causes neoplasm"" supported by the sentence: ""Low vitamin D status in humans has been implicated in the etiology of neoplasia, autoimmune disease, cardiovascular disorders and infectious diseases.""?",False, +16017645,Ergocalciferol causes obesity disorder,27,This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.,"Is the triple ""Ergocalciferol causes obesity disorder"" supported by the sentence: ""This comprehensive evaluation of genetic polymorphisms in vitamin D metabolism-related genes and obesity-related traits did not provide strong evidence to support low vitamin D levels as a cause of obesity.""?",False, +15862130,Ergocalciferol causes type 2 diabetes mellitus,28,"CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.","Is the triple ""Ergocalciferol causes type 2 diabetes mellitus"" supported by the sentence: ""CONCLUSIONS: Higher baseline 25(OH)D independently predicted better beta-cell function and lower AUC(glucose) at follow-up, supporting a potential role for vitamin D in type 2 diabetes etiology.""?",False, +15179909,Ergocalciferol causes asthma,29,"OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.","Is the triple ""Ergocalciferol causes asthma"" supported by the sentence: ""OBJECTIVE: To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency.""?",False, +14594790,Ergocalciferol causes Insulin resistance,30,"In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.","Is the triple ""Ergocalciferol causes Insulin resistance"" supported by the sentence: ""In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.""?",False, +14004176,Ergocalciferol causes Pain,31,The independent role of vitamin D in the etiology of pain remains controversial.,"Is the triple ""Ergocalciferol causes Pain"" supported by the sentence: ""The independent role of vitamin D in the etiology of pain remains controversial.""?",False, +12191251,Ergocalciferol causes osteoporosis,32,"We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.","Is the triple ""Ergocalciferol causes osteoporosis"" supported by the sentence: ""We therefore aimed to assess vitamin D status in men with idiopathic osteoporosis, in whom possible secondary causes of osteoporosis had been excluded, and to determine the extent of change in biologically active ""free"" vitamin D caused by variation in plasma DBP concentrations.""?",False, +11612180,Ergocalciferol causes colorectal neoplasm,33,There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.,"Is the triple ""Ergocalciferol causes colorectal neoplasm"" supported by the sentence: ""There is also recent evidence supporting a protective effect of calcium and vitamin D in the etiology of colorectal neoplasia.""?",False, +11557471,Ergocalciferol causes vitamin D deficiency,34,"Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).","Is the triple ""Ergocalciferol causes vitamin D deficiency"" supported by the sentence: ""Most studies reported included women at high risk of vitamin D deficiency, because of low vitamin D and calcium intake or decreased ability to synthesize endogenous vitamin D (attributable to lack of sun exposure or to heavily pigmented skin).""?",False, +11557464,Ergocalciferol causes inflammatory bowel disease,35,Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.,"Is the triple ""Ergocalciferol causes inflammatory bowel disease"" supported by the sentence: ""Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD.""?",False, +11275618,Ergocalciferol causes type 1 diabetes mellitus,36,These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol causes type 1 diabetes mellitus"" supported by the sentence: ""These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.""?",False, +10362733,Ergocalciferol causes multiple sclerosis,37,Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.,"Is the triple ""Ergocalciferol causes multiple sclerosis"" supported by the sentence: ""Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS.""?",False, +8719466,Ergocalciferol causes diabetes mellitus,38,"In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).","Is the triple ""Ergocalciferol causes diabetes mellitus"" supported by the sentence: ""In order to further investigate the radical scavenging and anti-arteriosclerotic activities of vitamin K2 and estradiol, the comparative effects of vitamin K2 and estradiol on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis with diabetes mellitus was induced by vitamin D2 and radical producing substance, streptozotocin (STZ).""?",False, +8407906,Ergocalciferol causes Marchiafava-Bignami disease,39,Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.,"Is the triple ""Ergocalciferol causes Marchiafava-Bignami disease"" supported by the sentence: ""Metabolic bone disease due to calcium and vitamin D malabsorption is a well-defined consequence of gastrectomy and to a lesser extent of pancreatic insufficiency.""?",False, +7553325,Ergocalciferol causes prostate cancer,40,"OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).","Is the triple ""Ergocalciferol causes prostate cancer"" supported by the sentence: ""OBJECTIVES: Because epidemiologic evidence has demonstrated that vitamin D may play a role in the etiology of prostate cancer, we tested the inhibitory effect of the biologically active form of vitamin D (1,25-D) on the cell proliferation of human prostate epithelial and stromal cells in a chemically defined situation in the presence and absence of dihydrotestosterone (DHT).""?",False, +7357695,Ergocalciferol causes bone fracture,41,Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.,"Is the triple ""Ergocalciferol causes bone fracture"" supported by the sentence: ""Impaired calcium and vitamin D homeostasis in the elderly results in (senile) secondary hyperparathyroidism and increased bone resorption leading to increased fracture risk.""?",False, +25936029,Ergocalciferol affects nutritional disorder,42,"Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.","Is the triple ""Ergocalciferol affects nutritional disorder"" supported by the sentence: ""Effect of dietary deficiency in vitamin D, calcium, and phosphorus on the ultrastructure of the rat parathyroid gland.""?",False, +25430100,Ergocalciferol affects primary hyperparathyroidism,43,Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.""?",False, +24682916,Ergocalciferol affects bone fracture,44,"Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women.""?",False, +24133915,Ergocalciferol affects HIV infectious disease,45,Potential immune modulatory effect of vitamin D in HIV infection: A review.,"Is the triple ""Ergocalciferol affects HIV infectious disease"" supported by the sentence: ""Potential immune modulatory effect of vitamin D in HIV infection: A review.""?",False, +23716846,Ergocalciferol affects Premature birth,46,Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""Some evidence indicates that most calcium absorption is non-vitamin D dependent in the first weeks of life in both preterm and term infants.""?",False, +22436428,Ergocalciferol affects obesity disorder,47,Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).,"Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Associations of physical activity with vitamin D status depends on obesity status in old adults.PURPOSE: Obesity has been associated with low 25-hydroxy-vitamin D (25OHD).""?",False, +22382447,Ergocalciferol affects Pregnancy,48,Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Early pregnancy vitamin D and the risk of adverse maternal and infant outcomes: a retrospective cohort study.BACKGROUND: Previous evidence has suggested that lower gestational vitamin D levels might increase the risks of adverse pregnancy and birth outcomes.""?",False, +21132793,Ergocalciferol affects breast neoplasm,49,"As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.","Is the triple ""Ergocalciferol affects breast neoplasm"" supported by the sentence: ""As vitamin D may play a key role in the modulation of the immune system, the objective of this work was to evaluate the impact of vitamin D on the breast cancer progression and mammary tumor microenvironment.""?",False, +20959246,Ergocalciferol affects diabetes mellitus,50,These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.,"Is the triple ""Ergocalciferol affects diabetes mellitus"" supported by the sentence: ""These findings shed light on mechanisms underlying the ameliorative effects of Vit D on diabetes mellitus.""?",False, +20298561,Ergocalciferol affects inflammatory bowel disease,51,"We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.","Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D.""?",False, +20058982,Ergocalciferol affects gestational diabetes,52,TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""TWEETABLE ABSTRACT: Low blood vitamin D increases gestational diabetes mellitus (GDM) risk.""?",False, +19907316,Ergocalciferol affects gestational diabetes,53,This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.,"Is the triple ""Ergocalciferol affects gestational diabetes"" supported by the sentence: ""This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.""?",False, +19815602,Ergocalciferol affects ulcerative colitis,54,Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.,"Is the triple ""Ergocalciferol affects ulcerative colitis"" supported by the sentence: ""Further larger studies are needed to investigate the effects of vitamin D in ulcerative colitis.""?",False, +19320344,Ergocalciferol affects Premature birth,55,We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.,"Is the triple ""Ergocalciferol affects Premature birth"" supported by the sentence: ""We performed a nested case-control study to investigate the effect of vitamin D on preterm birth.""?",False, +19221129,Ergocalciferol affects non-alcoholic fatty liver disease,56,"Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.","Is the triple ""Ergocalciferol affects non-alcoholic fatty liver disease"" supported by the sentence: ""Vitamin D (VitD) has been implicated in NAFLD pathogenesis because it has roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation.""?",False, +18424308,Ergocalciferol affects vitamin D deficiency,57,Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.,"Is the triple ""Ergocalciferol affects vitamin D deficiency"" supported by the sentence: ""Effects of a 10-day course of a high dose calciferol versus a single mega dose of ergocalciferol in correcting vitamin D deficiency.""?",False, +18115621,Ergocalciferol affects asthma,58,"BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""BACKGROUND: Low levels of vitamin D are associated with asthma severity, airway remodeling, and exacerbation rate increase, especially in nonatopic asthma.""?",False, +17654393,Ergocalciferol affects optic neuritis,59,"CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.","Is the triple ""Ergocalciferol affects optic neuritis"" supported by the sentence: ""CONCLUSION: Vitamin D levels affect AON severity, whereas younger age, attack severity, and male sex affect AON recovery.""?",False, +17646826,Ergocalciferol affects migraine disorder,60,"However, the data examining the relation of vitamin D with migraine are limited.","Is the triple ""Ergocalciferol affects migraine disorder"" supported by the sentence: ""However, the data examining the relation of vitamin D with migraine are limited.""?",False, +17581908,Ergocalciferol affects Pain,61,Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.,"Is the triple ""Ergocalciferol affects Pain"" supported by the sentence: ""Vitamin D might play an important role in mechanisms being involved in central processing of evoked pain stimuli but less so for spontaneous clinical pain.""?",False, +17056932,Ergocalciferol affects sarcopenia,62,"Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Smoking increased risk of sarcopenia, and intakes of total energy, vitamin D, protein and branched-chain amino acid significantly decreased risk of sarcopenia.""?",False, +16630786,Ergocalciferol affects sarcopenia,63,"Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.","Is the triple ""Ergocalciferol affects sarcopenia"" supported by the sentence: ""Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.""?",False, +16542255,Ergocalciferol affects melanoma,64,"Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.","Is the triple ""Ergocalciferol affects melanoma"" supported by the sentence: ""Recently, both vitamin D and beta-blocker use seem to play a beneficial role in melanoma progression.""?",False, +16343274,Ergocalciferol affects restless legs syndrome,65,"Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.","Is the triple ""Ergocalciferol affects restless legs syndrome"" supported by the sentence: ""Vitamin D may play an important role in dopamine function, but the role of vitamin D in restless legs syndrome has not been examined.""?",False, +16273798,Ergocalciferol affects Insulin resistance,66,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, +16273796,Ergocalciferol affects type 2 diabetes mellitus,67,"Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.","Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.""?",False, +15812657,Ergocalciferol affects prostate cancer,68,Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest.""?",False, +15750325,Ergocalciferol affects polycystic ovary syndrome,69,"Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.","Is the triple ""Ergocalciferol affects polycystic ovary syndrome"" supported by the sentence: ""Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D.""?",False, +15694248,Ergocalciferol affects mood disorder,70,"BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.","Is the triple ""Ergocalciferol affects mood disorder"" supported by the sentence: ""BACKGROUND: Low levels of serum 25-hydroxyvitamin D (25[OH]D), a reliable measurement of vitamin D, have been implicated in several mood disorders.""?",False, +15543952,Ergocalciferol affects osteoporosis,71,"Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.","Is the triple ""Ergocalciferol affects osteoporosis"" supported by the sentence: ""Increased intake or supplementation of vitamin D is often recommended for normal bone health; however, its preventive effect on osteoporosis has not been fully evaluated.""?",False, +15528071,Ergocalciferol affects Alzheimer disease,72,These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.,"Is the triple ""Ergocalciferol affects Alzheimer disease"" supported by the sentence: ""These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration.""?",False, +15258155,Ergocalciferol affects obesity disorder,73,"Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.","Is the triple ""Ergocalciferol affects obesity disorder"" supported by the sentence: ""Vitamin D concentrations are depressed in the severely obese, but the impact of weight loss via RYGB is unknown.""?",False, +14609756,Ergocalciferol affects tuberculosis,74,Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.,"Is the triple ""Ergocalciferol affects tuberculosis"" supported by the sentence: ""Effect of vitamin D on tuberculosis and HIV replication depends on conversion to calcitriol and concentration.""?",False, +14384550,Ergocalciferol affects psoriasis,75,"CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.","Is the triple ""Ergocalciferol affects psoriasis"" supported by the sentence: ""CONCLUSION: Climate therapy with sun exposure had a positive effect on psoriasis, vitamin D production, lipid and carbohydrate status.""?",False, +14233188,Ergocalciferol affects Insulin resistance,76,The possible correlations of the calciotropic hormones with insulin resistance were also examined.,"Is the triple ""Ergocalciferol affects Insulin resistance"" supported by the sentence: ""The possible correlations of the calciotropic hormones with insulin resistance were also examined.""?",False, +13916047,Ergocalciferol affects hip fracture,77,"RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]).""?",False, +13794313,Ergocalciferol affects multiple sclerosis,78,"Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""Among environmental factors, Epstein-Barr virus, vitamin D and smoking appear to play a role in developing MS.""?",False, +13764162,Ergocalciferol affects type 2 diabetes mellitus,79,The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.,"Is the triple ""Ergocalciferol affects type 2 diabetes mellitus"" supported by the sentence: ""The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.""?",False, +13437693,Ergocalciferol affects Crohn disease,80,These findings suggest that vitD may play a therapeutic role in CD.,"Is the triple ""Ergocalciferol affects Crohn disease"" supported by the sentence: ""These findings suggest that vitD may play a therapeutic role in CD.""?",False, +13211992,Ergocalciferol affects type 1 diabetes mellitus,81,BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.""?",False, +13015298,Ergocalciferol affects asthma,82,"Although vitamin D has important immunologic effects, its relation with asthma is unknown.","Is the triple ""Ergocalciferol affects asthma"" supported by the sentence: ""Although vitamin D has important immunologic effects, its relation with asthma is unknown.""?",False, +12698804,Ergocalciferol affects chronic renal failure syndrome,83,[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].,"Is the triple ""Ergocalciferol affects chronic renal failure syndrome"" supported by the sentence: ""[The metabolic effect of vitamins D in chronic renal insufficiency (author's transl)].""?",False, +12502345,Ergocalciferol affects inflammatory bowel disease,84,This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.,"Is the triple ""Ergocalciferol affects inflammatory bowel disease"" supported by the sentence: ""This finding provides strong evidence that vitamin D status could be an important regulator of immunity IBD.""?",False, +12032067,Ergocalciferol affects multiple sclerosis,85,"If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.","Is the triple ""Ergocalciferol affects multiple sclerosis"" supported by the sentence: ""If humans have a similar gender difference in vitamin D(3) metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men.""?",False, +11831475,Ergocalciferol affects bone fracture,86,"BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.","Is the triple ""Ergocalciferol affects bone fracture"" supported by the sentence: ""BACKGROUND: Inadequate serum vitamin D is associated with secondary hyperparathyroidism, increased bone turnover, and bone loss, which increased fracture risk.""?",False, +10991167,Ergocalciferol affects type 1 diabetes mellitus,87,CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.,"Is the triple ""Ergocalciferol affects type 1 diabetes mellitus"" supported by the sentence: ""CONCLUSION/INTERPRETATION: Vitamin D status increases the expression of Type 1 diabetes in NOD mice.""?",False, +10917919,Ergocalciferol affects primary hyperparathyroidism,88,Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.,"Is the triple ""Ergocalciferol affects primary hyperparathyroidism"" supported by the sentence: ""Our study aimed to investigate the impact of vitamin D status on skeletal involvement in PHPT.""?",False, +10608353,Ergocalciferol affects Pregnancy,89,Effect of overdose of vitamin D2 on pregnancy in the rat.,"Is the triple ""Ergocalciferol affects Pregnancy"" supported by the sentence: ""Effect of overdose of vitamin D2 on pregnancy in the rat.""?",False, +8987937,Ergocalciferol affects hip fracture,90,"To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.","Is the triple ""Ergocalciferol affects hip fracture"" supported by the sentence: ""To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years.""?",False, +8925552,Ergocalciferol affects prostate cancer,91,Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.,"Is the triple ""Ergocalciferol affects prostate cancer"" supported by the sentence: ""Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk.""?",False, +8894668,Ergocalciferol affects Marchiafava-Bignami disease,92,"However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.","Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""However, little is known about the effects of vitamin D on apoptosis in bone cells and about the contribution of this process to the effect of vitamin D on bone mineral loss.""?",False, +8321224,Ergocalciferol affects neoplasm,93,Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.,"Is the triple ""Ergocalciferol affects neoplasm"" supported by the sentence: ""Retinoids and vitamin D are known to exert important anti-tumour effects in a variety of cell types.""?",False, +7878820,Ergocalciferol affects Marchiafava-Bignami disease,94,High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.,"Is the triple ""Ergocalciferol affects Marchiafava-Bignami disease"" supported by the sentence: ""High intakes of calcium and vitamin D potentiate the bone loss prevention effects of hormone replacement therapy in postmenopausal women.""?",False, +21952380,Ergocalciferol produces obesity disorder,95,"Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.","Is the triple ""Ergocalciferol produces obesity disorder"" supported by the sentence: ""Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects.""?",False, +21636964,Ergocalciferol produces asthma,96,"Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.","Is the triple ""Ergocalciferol produces asthma"" supported by the sentence: ""Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun-induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test.""?",False, +20636497,Ergocalciferol produces Pregnancy,97,"Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.","Is the triple ""Ergocalciferol produces Pregnancy"" supported by the sentence: ""Significant changes in vitamin D metabolism during pregnancy such as increased production of the ""active vitamin D hormone"" calcitriol support the important role of vitamin D in this setting.""?",False, +20444810,Ergocalciferol produces Alzheimer disease,98,"Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.","Is the triple ""Ergocalciferol produces Alzheimer disease"" supported by the sentence: ""Sun exposure, independent of vitamin D production, may be protective against multiple Sclerosis, Parkinson's disease and Alzheimer's disease.""?",False, +15318015,Ergocalciferol produces melanoma,99,"Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.","Is the triple ""Ergocalciferol produces melanoma"" supported by the sentence: ""Effects of light on the skin include production of Vitamin D, tanning, ageing of the skin, and the skin cancers basal cell and squamous cell carcinomas, and malignant melanoma.""?",False, +14384547,Ergocalciferol produces psoriasis,100,"Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.","Is the triple ""Ergocalciferol produces psoriasis"" supported by the sentence: ""Effect of climate therapy at Gran Canaria on vitamin D production, blood glucose and lipids in patients with psoriasis.""?",False, diff --git a/false_sentence_data.csv b/false_sentence_data.csv index 2bf0cc0..68d0861 100644 --- a/false_sentence_data.csv +++ b/false_sentence_data.csv @@ -1,4 +1,3 @@ -SENTENCE_ID,PMID,TYPE,NUMBER,SENT_START_INDEX,SENTENCE,SECTION_HEADER,NORMALIZED_SECTION_HEADER,Column,Column 1,,,,,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,,,, 2,,,,,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,,,, 3,,,,,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,,,, diff --git a/false_triple_data.csv b/false_triple_data.csv index 340acf6..c0f094c 100644 --- a/false_triple_data.csv +++ b/false_triple_data.csv @@ -398,4603 +398,4603 @@ 24691450,498,,related to,,Methylprednisolone,,,,plantar fasciitis,,,,, 24586108,499,,related to,,Methylprednisolone,,,,alcoholic hepatitis,,,,, 24559507,500,,related to,,Methylprednisolone,,,,respiratory system disorder,,,,, -23573980,1,,related to,,Methylprednisolone,,,,pneumonia,,,,, -23514846,2,,related to,,Methylprednisolone,,,,carpal tunnel syndrome,,,,, -23364897,3,,related to,,Methylprednisolone,,,,West syndrome,,,,, -22495910,4,,related to,,Methylprednisolone,,,,myocarditis,,,,, -22175056,5,,related to,,Methylprednisolone,,,,myopathy,,,,, -20879022,6,,related to,,Methylprednisolone,,,,Pain,,,,, -20342058,7,,related to,,Methylprednisolone,,,,chronic progressive multiple sclerosis,,,,, -20290784,8,,related to,,Methylprednisolone,,,,membranous glomerulonephritis,,,,, -20286711,9,,related to,,Methylprednisolone,,,,neuromyelitis optica,,,,, -19340184,10,,related to,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, -18938435,11,,related to,,Methylprednisolone,,,,graft versus host disease,,,,, -17333962,12,,related to,,Methylprednisolone,,,,Inflammation,,,,, -17288506,13,,related to,,Methylprednisolone,,,,autoimmune thrombocytopenic purpura,,,,, -15936572,14,,related to,,Methylprednisolone,,,,endocrine exophthalmos,,,,, -15072844,15,,related to,,Methylprednisolone,,,,Edema,,,,, -14876749,16,,related to,,Methylprednisolone,,,,osteoarthritis,,,,, -14399082,17,,related to,,Methylprednisolone,,,,aplastic anemia,,,,, -14398237,18,,related to,,Methylprednisolone,,,,IgA glomerulonephritis,,,,, -14278238,19,,related to,,Methylprednisolone,,,,"dermatitis, atopic",,,,, -14166179,20,,related to,,Methylprednisolone,,,,cardiac arrest,,,,, -12755316,21,,related to,,Methylprednisolone,,,,plasma cell myeloma,,,,, -12183687,22,,related to,,Methylprednisolone,,,,acute lymphoblastic leukemia,,,,, -11720471,23,,related to,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, -10812685,24,,related to,,Methylprednisolone,,,,immunoglobulin a vasculitis,,,,, -10763477,25,,related to,,Methylprednisolone,,,,ulcerative colitis,,,,, -10558884,26,,related to,,Methylprednisolone,,,,lupus nephritis,,,,, -10130342,27,,related to,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, -9229208,28,,related to,,Methylprednisolone,,,,vestibular neuronitis,,,,, -9003326,29,,related to,,Methylprednisolone,,,,systemic sclerosis,,,,, -8447481,30,,related to,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -8282330,31,,related to,,Methylprednisolone,,,,spinal cord injury,,,,, -7944646,32,,related to,,Methylprednisolone,,,,myasthenia gravis,,,,, -7668599,33,,related to,,Methylprednisolone,,,,multiple sclerosis,,,,, -7443745,34,,related to,,Methylprednisolone,,,,asthma,,,,, -24973247,35,,causes,,Methylprednisolone,,,,lupus nephritis,,,,, -24161886,36,,causes,,Methylprednisolone,,,,Edema,,,,, -18534953,37,,causes,,Methylprednisolone,,,,Inflammation,,,,, -18260665,38,,causes,,Methylprednisolone,,,,neoplasm,,,,, -17307095,39,,causes,,Methylprednisolone,,,,pneumonia,,,,, -15906641,40,,causes,,Methylprednisolone,,,,Pain,,,,, -13166073,41,,causes,,Methylprednisolone,,,,thrombocytopenia,,,,, -12672767,42,,causes,,Methylprednisolone,,,,drug-induced liver injury,,,,, -8525599,43,,causes,,Methylprednisolone,,,,myopathy,,,,, -27357949,44,,affects,,Methylprednisolone,,,,neoplasm,,,,, -24420470,45,,affects,,Methylprednisolone,,,,Inflammation,,,,, -23472756,46,,affects,,Methylprednisolone,,,,Inflammation,,,,, -20530617,47,,affects,,Methylprednisolone,,,,systemic sclerosis,,,,, -20254789,48,,affects,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, -17649050,49,,affects,,Methylprednisolone,,,,optic nerve disorder,,,,, -16634377,50,,affects,,Methylprednisolone,,,,myasthenia gravis,,,,, -16277488,51,,affects,,Methylprednisolone,,,,neuromyelitis optica,,,,, -15906642,52,,affects,,Methylprednisolone,,,,Pain,,,,, -15610554,53,,affects,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -15186368,54,,affects,,Methylprednisolone,,,,graft versus host disease,,,,, -14891106,55,,affects,,Methylprednisolone,,,,kidney disorder,,,,, -11819955,56,,affects,,Methylprednisolone,,,,spinal cord injury,,,,, -10845505,57,,affects,,Methylprednisolone,,,,Pain,,,,, -10048898,58,,affects,,Methylprednisolone,,,,ulcerative colitis,,,,, -9646753,59,,affects,,Methylprednisolone,,,,multiple sclerosis,,,,, -9346353,60,,affects,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, -9107378,61,,affects,,Methylprednisolone,,,,Edema,,,,, -8596544,62,,affects,,Methylprednisolone,,,,asthma,,,,, -8330909,63,,affects,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, -19744632,64,,disrupts,,Methylprednisolone,,,,Edema,,,,, -18407557,65,,disrupts,,Methylprednisolone,,,,thrombocytopenia,,,,, -11106658,66,,disrupts,,Methylprednisolone,,,,Pain,,,,, -8640603,67,,disrupts,,Methylprednisolone,,,,Inflammation,,,,, -23934495,68,,prevents,,Methylprednisolone,,,,Cognitive impairment,,,,, -20014108,69,,prevents,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -18266414,70,,prevents,,Methylprednisolone,,,,Abdominal pain,,,,, -14967074,71,,prevents,,Methylprednisolone,,,,asthma,,,,, -9744990,72,,prevents,,Methylprednisolone,,,,ovarian hyperstimulation syndrome,,,,, -8345063,73,,prevents,,Methylprednisolone,,,,Pain,,,,, -8291272,74,,prevents,,Methylprednisolone,,,,graft versus host disease,,,,, -7980138,75,,prevents,,Methylprednisolone,,,,spinal cord injury,,,,, -7414405,76,,prevents,,Methylprednisolone,,,,Edema,,,,, -18106042,77,,predisposes,,Methylprednisolone,,,,pneumonia,,,,, -9645180,78,,predisposes,,Methylprednisolone,,,,Inflammation,,,,, -12905337,79,,related to,,Cefotaxime,,,,Sepsis,,,,, -24475300,80,,affects,,Cefotaxime,,,,bacterial infectious disease,,,,, -23922029,81,,affects,,Cefotaxime,,,,Sepsis,,,,, -18672205,82,,affects,,Cefotaxime,,,,peritonitis,,,,, -15853591,83,,prevents,,Cefotaxime,,,,Sepsis,,,,, -19081412,84,,prevents,,Ceftriaxone,,,,bacterial infectious disease,,,,, -25827448,85,,related to,,Gefarnate,,,,gastric ulcer,,,,, -24296137,86,,related to,,Gefarnate,,,,duodenal ulcer,,,,, -25993651,87,,disrupts,,Gefarnate,,,,gastric ulcer,,,,, -17758516,88,,related to,,Neobiotic,,,,Inflammation,,,,, -10690423,89,,related to,,Neobiotic,,,,burn,,,,, -20263460,90,,affects,,Neobiotic,,,,neoplasm,,,,, -19744068,91,,affects,,Neobiotic,,,,Inflammation,,,,, -24669492,92,,disrupts,,Neobiotic,,,,bacterial infectious disease,,,,, -17119153,93,,disrupts,,Neobiotic,,,,neoplasm,,,,, -26428369,94,,prevents,,Neobiotic,,,,bacterial infectious disease,,,,, -25579460,95,,related to,,BLINATUMOMAB,,,,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,,,,, -22474123,96,,related to,,BLINATUMOMAB,,,,hematopoietic and lymphoid system neoplasm,,,,, -21947892,97,,related to,,BLINATUMOMAB,,,,acute lymphoblastic leukemia,,,,, -27155094,98,,related to,,Ciprofloxacin,,,,endophthalmitis,,,,, -16836665,99,,related to,,Ciprofloxacin,,,,Crohn disease,,,,, -19572117,100,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, -19572117,101,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, -12385742,102,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -12385742,103,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -17007621,104,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -17007621,105,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -9387116,106,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -8212496,107,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, -25648466,108,,causes,,Ciprofloxacin,,,,abscess,,,,, -24716241,109,,causes,,Ciprofloxacin,,,,peritonitis,,,,, -17154464,110,,causes,,Ciprofloxacin,,,,prostatitis,,,,, -14369807,111,,causes,,Ciprofloxacin,,,,neutropenia,,,,, -13950319,112,,causes,,Ciprofloxacin,,,,pneumonia,,,,, -10209213,113,,causes,,Ciprofloxacin,,,,infectious disease,,,,, -7113733,114,,causes,,Ciprofloxacin,,,,osteomyelitis,,,,, -21996198,115,,affects,,Ciprofloxacin,,,,infectious disease,,,,, -16563368,116,,affects,,Ciprofloxacin,,,,Fever,,,,, -16125923,117,,affects,,Ciprofloxacin,,,,osteomyelitis,,,,, -12942741,118,,affects,,Ciprofloxacin,,,,Crohn disease,,,,, -11440816,119,,affects,,Ciprofloxacin,,,,typhoid fever,,,,, -11267024,120,,affects,,Ciprofloxacin,,,,eye infectious disorder,,,,, -10672042,121,,affects,,Ciprofloxacin,,,,Abdominal Infection,,,,, -9891814,122,,affects,,Ciprofloxacin,,,,pneumonia,,,,, -9122989,123,,affects,,Ciprofloxacin,,,,infectious disease,,,,, -8956826,124,,affects,,Ciprofloxacin,,,,Pseudomonas infection,,,,, -8956825,125,,affects,,Ciprofloxacin,,,,cystic fibrosis,,,,, -8669720,126,,affects,,Ciprofloxacin,,,,Fever,,,,, -7886704,127,,affects,,Ciprofloxacin,,,,bronchiectasis,,,,, -7886701,128,,affects,,Ciprofloxacin,,,,chronic bronchitis,,,,, -7781719,129,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, -7592205,130,,affects,,Ciprofloxacin,,,,chronic obstructive pulmonary disease,,,,, -18400322,131,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, -26984478,132,,disrupts,,Ciprofloxacin,,,,Fever,,,,, -26466958,133,,disrupts,,Ciprofloxacin,,,,pneumonia,,,,, -18480207,134,,disrupts,,Ciprofloxacin,,,,infectious disease,,,,, -10323767,135,,disrupts,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, -27242944,136,,prevents,,Ciprofloxacin,,,,pyelonephritis,,,,, -21807033,137,,prevents,,Ciprofloxacin,,,,Infection,,,,, -16138544,138,,prevents,,Ciprofloxacin,,,,diarrheal disease,,,,, -15438014,139,,prevents,,Ciprofloxacin,,,,Sepsis,,,,, -14202377,140,,prevents,,Ciprofloxacin,,,,plague,,,,, -12292532,141,,prevents,,Ciprofloxacin,,,,endophthalmitis,,,,, -10767980,142,,prevents,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, -9947057,143,,prevents,,Ciprofloxacin,,,,bacterial infectious disease,,,,, -8364719,144,,prevents,,Ciprofloxacin,,,,pneumonia,,,,, -8054296,145,,prevents,,Ciprofloxacin,,,,infectious disease,,,,, -18366035,146,,predisposes,,Ciprofloxacin,,,,infectious disease,,,,, -15459841,147,,predisposes,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, -8758764,148,,predisposes,,Ciprofloxacin,,,,gonorrhea,,,,, -15493028,149,,disrupts,,Chloramphenicol,,,,acne,,,,, -21241586,150,,prevents,,Chloramphenicol,,,,eye infectious disorder,,,,, -16722213,151,,causes,,Rebamipide,,,,osteoarthritis,,,,, -27679650,152,,affects,,Rebamipide,,,,peptic ulcer disease,,,,, -10125846,153,,affects,,Rebamipide,,,,gastric ulcer,,,,, -16923576,154,,disrupts,,Rebamipide,,,,gastritis,,,,, -20953135,155,,prevents,,Rebamipide,,,,peptic ulcer disease,,,,, -13727344,156,,prevents,,Rebamipide,,,,gastritis,,,,, -10452606,157,,prevents,,Rebamipide,,,,gastric ulcer,,,,, -23020953,158,,related to,,DINUTUXIMAB,,,,neoplasm,,,,, -12385638,159,,related to,,DINUTUXIMAB,,,,neuroblastoma,,,,, -21974466,160,,causes,,DINUTUXIMAB,,,,neuroblastoma,,,,, -23929422,161,,related to,,BRENTUXIMAB VEDOTIN,,,,anaplastic large cell lymphoma,,,,, -23730531,162,,related to,,BRENTUXIMAB VEDOTIN,,,,mycosis fungoides,,,,, -23653011,163,,related to,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, -23065539,164,,related to,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, -21812241,165,,related to,,BRENTUXIMAB VEDOTIN,,,,Hodgkins lymphoma,,,,, -21657994,166,,related to,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -21657993,167,,related to,,BRENTUXIMAB VEDOTIN,,,,primary cutaneous T-cell non-Hodgkin lymphoma,,,,, -22071488,168,,has part,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -21553377,169,,has part,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, -23435913,170,,affects,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, -20170701,171,,causes,,Tetracycline,,,,periodontitis,,,,, -19472933,172,,causes,,Tetracycline,,,,Helicobacter pylori infectious disease,,,,, -18080767,173,,affects,,Tetracycline,,,,periodontitis,,,,, -17969405,174,,affects,,Tetracycline,,,,bacterial infectious disease,,,,, -24565223,175,,prevents,,Tetracycline,,,,bacterial infectious disease,,,,, -10847016,176,,prevents,,Tetracycline,,,,inclusion conjunctivitis,,,,, -12376615,177,,related to,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -11754791,178,,related to,,(Alginate)n,,,,cystic fibrosis,,,,, -10599430,179,,related to,,(Alginate)n,,,,obesity disorder,,,,, -27435796,180,,affects,,(Alginate)n,,,,cystic fibrosis,,,,, -27132270,181,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -23415127,182,,affects,,(Alginate)n,,,,obesity disorder,,,,, -19854419,183,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -8246131,184,,disrupts,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -11492096,185,,prevents,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, -23508922,186,,predisposes,,(Alginate)n,,,,obesity disorder,,,,, -11597598,187,,related to,,Zolimidine,,,,peptic ulcer disease,,,,, -20742970,188,,causes,,Chlorhexidine,,,,infectious disease,,,,, -16147932,189,,causes,,Chlorhexidine,,,,gingivitis,,,,, -15413413,190,,causes,,Chlorhexidine,,,,stomatitis,,,,, -13735208,191,,causes,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, -23793676,192,,affects,,Chlorhexidine,,,,Infection,,,,, -21319017,193,,affects,,Chlorhexidine,,,,pneumonia,,,,, -20585434,194,,affects,,Chlorhexidine,,,,stomatitis,,,,, -13503760,195,,affects,,Chlorhexidine,,,,periodontal disorder,,,,, -8506996,196,,affects,,Chlorhexidine,,,,gingivitis,,,,, -25489531,197,,disrupts,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, -22304373,198,,disrupts,,Chlorhexidine,,,,dental caries,,,,, -21939464,199,,disrupts,,Chlorhexidine,,,,Infection,,,,, -19793680,200,,disrupts,,Chlorhexidine,,,,bacterial infectious disease,,,,, -18040358,201,,disrupts,,Chlorhexidine,,,,infectious disease,,,,, -11272633,202,,disrupts,,Chlorhexidine,,,,gingivitis,,,,, -26042520,203,,prevents,,Chlorhexidine,,,,staphylococcal infection,,,,, -22617089,204,,prevents,,Chlorhexidine,,,,periodontitis,,,,, -22038778,205,,prevents,,Chlorhexidine,,,,bacterial infectious disease,,,,, -22000060,206,,prevents,,Chlorhexidine,,,,Infection,,,,, -21737487,207,,prevents,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, -19905103,208,,prevents,,Chlorhexidine,,,,periodontal disorder,,,,, -16765643,209,,prevents,,Chlorhexidine,,,,Neonatal sepsis,,,,, -14052320,210,,prevents,,Chlorhexidine,,,,pneumonia,,,,, -11830955,211,,prevents,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, -11145796,212,,prevents,,Chlorhexidine,,,,infectious disease,,,,, -10739867,213,,prevents,,Chlorhexidine,,,,stomatitis,,,,, -10141569,214,,prevents,,Chlorhexidine,,,,dental caries,,,,, -7990742,215,,prevents,,Chlorhexidine,,,,gingivitis,,,,, -23454202,216,,predisposes,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, -19942414,217,,predisposes,,Chlorhexidine,,,,periodontal disorder,,,,, -18735040,218,,predisposes,,Chlorhexidine,,,,dental caries,,,,, -16765642,219,,predisposes,,Chlorhexidine,,,,Neonatal sepsis,,,,, -24905090,220,,causes,,Nicergoline,,,,depressive disorder,,,,, -25103280,221,,related to,,RAMUCIRUMAB,,,,hepatocellular carcinoma,,,,, -22612331,222,,related to,,RAMUCIRUMAB,,,,neoplasm,,,,, -21600131,223,,related to,,RAMUCIRUMAB,,,,non-small cell lung carcinoma,,,,, -22008312,224,,affects,,RAMUCIRUMAB,,,,neoplasm,,,,, -23569571,225,,related to,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, -24533103,226,,disrupts,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, -21884997,227,,related to,,Thioctic acid,,,,cystinuria,,,,, -20207321,228,,related to,,Thioctic acid,,,,chronic progressive multiple sclerosis,,,,, -18115881,229,,related to,,Thioctic acid,,,,hypertensive disorder,,,,, -15406106,230,,related to,,Thioctic acid,,,,optic neuritis,,,,, -12204809,231,,related to,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, -11741203,232,,related to,,Thioctic acid,,,,multiple sclerosis,,,,, -11010945,233,,related to,,Thioctic acid,,,,AIDS,,,,, -10648973,234,,related to,,Thioctic acid,,,,skin disorder,,,,, -7603472,235,,related to,,Thioctic acid,,,,diabetic neuropathy,,,,, -16842192,236,,causes,,Thioctic acid,,,,hypertensive disorder,,,,, -21111426,237,,affects,,Thioctic acid,,,,optic neuritis,,,,, -18505755,238,,affects,,Thioctic acid,,,,diabetic neuropathy,,,,, -17198477,239,,affects,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, -12393284,240,,affects,,Thioctic acid,,,,Alzheimer disease,,,,, -9028391,241,,affects,,Thioctic acid,,,,hypertensive disorder,,,,, -21111429,242,,prevents,,Thioctic acid,,,,optic neuritis,,,,, -18775341,243,,prevents,,Thioctic acid,,,,skin disorder,,,,, -18076378,244,,prevents,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, -15377554,245,,prevents,,Thioctic acid,,,,stroke disorder,,,,, -13878249,246,,prevents,,Thioctic acid,,,,Alzheimer disease,,,,, -8826102,247,,prevents,,Thioctic acid,,,,hypertensive disorder,,,,, -8682086,248,,prevents,,Thioctic acid,,,,diabetic neuropathy,,,,, -15385084,249,,predisposes,,Thioctic acid,,,,Alzheimer disease,,,,, -26276598,250,,related to,,Ampicillin,,,,Sepsis,,,,, -19644222,251,,related to,,Ampicillin,,,,pneumonia,,,,, -27702232,252,,causes,,Ampicillin,,,,Sepsis,,,,, -15854005,253,,causes,,Ampicillin,,,,pneumonia,,,,, -14938843,254,,affects,,Ampicillin,,,,Sepsis,,,,, -8930713,255,,affects,,Ampicillin,,,,gonorrhea,,,,, -21012437,256,,disrupts,,Ampicillin,,,,gonorrhea,,,,, -24823382,257,,prevents,,Ampicillin,,,,Infection,,,,, -22838487,258,,prevents,,Ampicillin,,,,chorioamnionitis,,,,, -18801502,259,,prevents,,Ampicillin,,,,Sepsis,,,,, -17465667,260,,prevents,,Ampicillin,,,,pneumonia,,,,, -13675414,261,,predisposes,,Ampicillin,,,,Sepsis,,,,, -26048573,262,,causes,,Carbenicillin,,,,bacterial infectious disease,,,,, -19319362,263,,related to,,Benzoyl Peroxide,,,,acne,,,,, -10427135,264,,affects,,Benzoyl Peroxide,,,,acne,,,,, -7769964,265,,disrupts,,Benzoyl Peroxide,,,,acne,,,,, -12531968,266,,prevents,,Benzoyl Peroxide,,,,acne,,,,, -11597597,267,,related to,,Proglumide,,,,peptic ulcer disease,,,,, -18195146,268,,causes,,Pirenzepine,,,,peptic ulcer disease,,,,, -13022427,269,,affects,,Pirenzepine,,,,gastroesophageal reflux disease,,,,, -18547780,270,,prevents,,Pirenzepine,,,,peptic ulcer disease,,,,, -9345084,271,,related to,,Magnesium Oxide,,,,constipation disorder,,,,, -19628284,272,,disrupts,,Magnesium Oxide,,,,constipation disorder,,,,, -25714783,273,,prevents,,Ticarcillin,,,,Sepsis,,,,, -24735602,274,,related to,,Urea,,,,hepatocellular carcinoma,,,,, -18901918,275,,related to,,Urea,,,,radiodermatitis,,,,, -16423422,276,,related to,,Urea,,,,skin disorder,,,,, -16423421,277,,related to,,Urea,,,,psoriasis,,,,, -10983160,278,,related to,,Urea,,,,"dermatitis, atopic",,,,, -9883467,279,,related to,,Urea,,,,diabetes mellitus,,,,, -9435238,280,,related to,,Urea,,,,type 2 diabetes mellitus,,,,, -7778173,281,,related to,,Urea,,,,ornithine carbamoyltransferase deficiency,,,,, -17162115,282,,causes,,Urea,,,,diabetes mellitus,,,,, -16469778,283,,causes,,Urea,,,,type 2 diabetes mellitus,,,,, -18510405,284,,affects,,Urea,,,,hepatocellular carcinoma,,,,, -10531949,285,,affects,,Urea,,,,diabetes mellitus,,,,, -8735554,286,,affects,,Urea,,,,type 2 diabetes mellitus,,,,, -25972859,287,,produces,,Urea,,,,citrullinemia,,,,, -18901919,288,,prevents,,Urea,,,,radiodermatitis,,,,, -15303897,289,,prevents,,Urea,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -19154964,290,,predisposes,,Urea,,,,type 2 diabetes mellitus,,,,, -21175471,291,,related to,,Mannitol,,,,intracranial hypertension,,,,, -17706176,292,,related to,,Mannitol,,,,acute kidney failure,,,,, -17429747,293,,related to,,Mannitol,,,,stroke disorder,,,,, -15130853,294,,related to,,Mannitol,,,,brain cancer,,,,, -13201402,295,,related to,,Mannitol,,,,cystic fibrosis,,,,, -12470912,296,,related to,,Mannitol,,,,brain edema,,,,, -11875924,297,,related to,,Mannitol,,,,ciguatera fish poisoning,,,,, -10780851,298,,related to,,Mannitol,,,,brain injury,,,,, -8946483,299,,related to,,Mannitol,,,,bronchiectasis,,,,, -7891128,300,,related to,,Mannitol,,,,injury,,,,, -26278567,301,,causes,,Mannitol,,,,brain cancer,,,,, -25099324,302,,causes,,Mannitol,,,,hearing loss disorder,,,,, -21259902,303,,causes,,Mannitol,,,,brain injury,,,,, -18351985,304,,causes,,Mannitol,,,,hypotensive disorder,,,,, -15545947,305,,causes,,Mannitol,,,,brain edema,,,,, -12105301,306,,causes,,Mannitol,,,,intracranial hypertension,,,,, -11383337,307,,causes,,Mannitol,,,,injury,,,,, -9825580,308,,causes,,Mannitol,,,,acute kidney failure,,,,, -22439282,309,,affects,,Mannitol,,,,acute kidney failure,,,,, -18431992,310,,affects,,Mannitol,,,,hypotensive disorder,,,,, -10780860,311,,affects,,Mannitol,,,,brain injury,,,,, -10701562,312,,affects,,Mannitol,,,,injury,,,,, -10686125,313,,affects,,Mannitol,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -9315186,314,,affects,,Mannitol,,,,intracranial hypertension,,,,, -7084537,315,,affects,,Mannitol,,,,brain edema,,,,, -27493988,316,,disrupts,,Mannitol,,,,injury,,,,, -26052295,317,,disrupts,,Mannitol,,,,brain edema,,,,, -18331127,318,,prevents,,Mannitol,,,,Pain,,,,, -17838550,319,,prevents,,Mannitol,,,,brain injury,,,,, -9550870,320,,prevents,,Mannitol,,,,acute kidney failure,,,,, -8530867,321,,prevents,,Mannitol,,,,brain edema,,,,, -7816754,322,,prevents,,Mannitol,,,,intracranial hypertension,,,,, -21038220,323,,exacerbates,,Mannitol,,,,intracranial hypertension,,,,, -23554906,324,,predisposes,,Mannitol,,,,brain injury,,,,, -23171283,325,,predisposes,,Mannitol,,,,acute kidney failure,,,,, -15337034,326,,predisposes,,Mannitol,,,,brain edema,,,,, -9368450,327,,predisposes,,Mannitol,,,,injury,,,,, -25560945,328,,affects,,Artesunic acid,,,,neoplasm,,,,, -20380317,329,,affects,,Artesunic acid,,,,neoplasm,,,,, -17022154,330,,affects,,Artesunic acid,,,,cytomegalovirus infection,,,,, -15447136,331,,affects,,Artesunic acid,,,,malaria,,,,, -14695052,332,,affects,,Artesunic acid,,,,Fever,,,,, -9350747,333,,affects,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, -19053159,334,,disrupts,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, -17269195,335,,disrupts,,Artesunic acid,,,,neoplasm,,,,, -16806460,336,,disrupts,,Artesunic acid,,,,malaria,,,,, -10013375,337,,prevents,,Artesunic acid,,,,schistosomiasis,,,,, -8540473,338,,prevents,,Artesunic acid,,,,malaria,,,,, -16567243,339,,predisposes,,Artesunic acid,,,,malaria,,,,, -27639365,340,,affects,,Artemether,,,,Fever,,,,, -25565511,341,,affects,,Artemether,,,,malaria,,,,, -19253720,342,,prevents,,Artemether,,,,malaria,,,,, -10002115,343,,prevents,,Artemether,,,,urinary schistosomiasis,,,,, -8716445,344,,causes,,Isoproterenol,,,,atrial fibrillation,,,,, -25912644,345,,affects,,Isoproterenol,,,,obstructive lung disease,,,,, -24900253,346,,affects,,Isoproterenol,,,,obesity disorder,,,,, -9298156,347,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, -7542857,348,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, -26721271,349,,disrupts,,Isoproterenol,,,,obesity disorder,,,,, -7635739,350,,predisposes,,Isoproterenol,,,,atrial fibrillation,,,,, -23874783,351,,related to,,Bacitracin A,,,,pneumonia,,,,, -26428368,352,,prevents,,Bacitracin A,,,,bacterial infectious disease,,,,, -18829774,353,,prevents,,Bacitracin A,,,,cardiac rhythm disease,,,,, -16650012,354,,subclass of,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, -26133976,355,,causes,,Diflunisal,,,,Pain,,,,, -26132411,356,,affects,,Diflunisal,,,,Pain,,,,, -26009871,357,,affects,,Diflunisal,,,,Fever,,,,, -26009870,358,,affects,,Diflunisal,,,,Fever,,,,, -13234484,359,,affects,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, -14757294,360,,prevents,,Diflunisal,,,,Pain,,,,, -17020332,361,,causes,,Salsalate,,,,Insulin resistance,,,,, -21902985,362,,affects,,Salsalate,,,,diabetes mellitus,,,,, -25541729,363,,disrupts,,Salsalate,,,,Insulin resistance,,,,, -19533984,364,,prevents,,Salsalate,,,,diabetes mellitus,,,,, -26431050,365,,causes,,Sodium salicylate,,,,Fever,,,,, -11882723,366,,affects,,Sodium salicylate,,,,Fever,,,,, -9968696,367,,affects,,Sodium salicylate,,,,Fever,,,,, -15893532,368,,predisposes,,Sodium salicylate,,,,Pain,,,,, -7201382,369,,subclass of,,Aspirin,,,,Salicylic Acid,,,,, -26818861,370,,related to,,Aspirin,,,,myocardial infarction,,,,, -26532873,371,,related to,,Aspirin,,,,classic familial adenomatous polyposis,,,,, -26329928,372,,related to,,Aspirin,,,,type 2 diabetes mellitus,,,,, -26168722,373,,related to,,Aspirin,,,,Inflammation,,,,, -24076103,374,,related to,,Aspirin,,,,Hemorrhage,,,,, -20241570,375,,related to,,Aspirin,,,,Pain,,,,, -18524506,376,,related to,,Aspirin,,,,cataract,,,,, -18008074,377,,related to,,Aspirin,,,,diabetes mellitus,,,,, -17483160,378,,related to,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, -16078277,379,,related to,,Aspirin,,,,preeclampsia,,,,, -15283505,380,,related to,,Aspirin,,,,thrombotic disease,,,,, -13829413,381,,related to,,Aspirin,,,,retinal vein occlusion,,,,, -13174915,382,,related to,,Aspirin,,,,ST-elevation myocardial infarction,,,,, -12865539,383,,related to,,Aspirin,,,,cardiovascular disorder,,,,, -12749655,384,,related to,,Aspirin,,,,Salicylic Acid,,,,, -12502970,385,,related to,,Aspirin,,,,coronary artery disorder,,,,, -10635434,386,,related to,,Aspirin,,,,rheumatic heart disease,,,,, -10534181,387,,related to,,Aspirin,,,,osteoarthritis,,,,, -10473195,388,,related to,,Aspirin,,,,asthma,,,,, -9315521,389,,related to,,Aspirin,,,,atrial fibrillation,,,,, -8718389,390,,related to,,Aspirin,,,,stroke disorder,,,,, -8430499,391,,related to,,Aspirin,,,,Ischemic stroke,,,,, -7718877,392,,related to,,Aspirin,,,,acute coronary syndrome,,,,, -8745735,393,,related to,,Aspirin,,,,Salicylic Acid,,,,, -12749656,394,,close match,,Aspirin,,,,Salicylic Acid,,,,, -8745736,395,,close match,,Aspirin,,,,Salicylic Acid,,,,, -10716638,396,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, -10182446,397,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, -8959647,398,,derives from,,Aspirin,,,,Salicylic Acid,,,,, -7421635,399,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, -9047883,400,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, -27550629,401,,causes,,Aspirin,,,,transient ischemic attack,,,,, -27093984,402,,causes,,Aspirin,,,,Sepsis,,,,, -26941889,403,,causes,,Aspirin,,,,colonic neoplasm,,,,, -26621273,404,,causes,,Aspirin,,,,diabetic retinopathy,,,,, -25682183,405,,causes,,Aspirin,,,,Toothache,,,,, -24276147,406,,causes,,Aspirin,,,,osteoarthritis,,,,, -23603605,407,,causes,,Aspirin,,,,infertility disorder,,,,, -22149437,408,,causes,,Aspirin,,,,myocardial infarction,,,,, -21269587,409,,causes,,Aspirin,,,,preeclampsia,,,,, -21190178,410,,causes,,Aspirin,,,,Varicose Ulcer,,,,, -20967677,411,,causes,,Aspirin,,,,cerebral infarction,,,,, -20453125,412,,causes,,Aspirin,,,,squamous cell carcinoma,,,,, -20257764,413,,causes,,Aspirin,,,,vascular disorder,,,,, -18467493,414,,causes,,Aspirin,,,,periodontitis,,,,, -18133593,415,,causes,,Aspirin,,,,acute lung injury,,,,, -17905974,416,,causes,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, -16266546,417,,causes,,Aspirin,,,,cardiovascular disorder,,,,, -15908394,418,,causes,,Aspirin,,,,arthritic joint disease,,,,, -15782733,419,,causes,,Aspirin,,,,ulcerative colitis,,,,, -15251529,420,,causes,,Aspirin,,,,myocardial ischemia,,,,, -15022291,421,,causes,,Aspirin,,,,pneumonia,,,,, -14953515,422,,causes,,Aspirin,,,,diabetes mellitus,,,,, -14693157,423,,causes,,Aspirin,,,,atrial fibrillation,,,,, -14660024,424,,causes,,Aspirin,,,,ischemic disease,,,,, -14296178,425,,causes,,Aspirin,,,,type 2 diabetes mellitus,,,,, -13914591,426,,causes,,Aspirin,,,,digestive system disorder,,,,, -13814866,427,,causes,,Aspirin,,,,Fever,,,,, -13639281,428,,causes,,Aspirin,,,,acute coronary syndrome,,,,, -13639280,429,,causes,,Aspirin,,,,Ischemic stroke,,,,, -13405854,430,,causes,,Aspirin,,,,hypertensive disorder,,,,, -13278968,431,,causes,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, -11251562,432,,causes,,Aspirin,,,,Pain,,,,, -10850020,433,,causes,,Aspirin,,,,migraine disorder,,,,, -10555051,434,,causes,,Aspirin,,,,duodenal ulcer,,,,, -9350599,435,,causes,,Aspirin,,,,active peptic ulcer disease,,,,, -9238263,436,,causes,,Aspirin,,,,blood coagulation disease,,,,, -8683872,437,,causes,,Aspirin,,,,stroke disorder,,,,, -8518235,438,,causes,,Aspirin,,,,peptic ulcer disease,,,,, -8466167,439,,causes,,Aspirin,,,,Headache,,,,, -8232293,440,,causes,,Aspirin,,,,Hemorrhage,,,,, -7594346,441,,causes,,Aspirin,,,,asthma,,,,, -7353622,442,,causes,,Aspirin,,,,gastric ulcer,,,,, -7227553,443,,causes,,Aspirin,,,,injury,,,,, -26773149,444,,affects,,Aspirin,,,,atrial fibrillation,,,,, -26425353,445,,affects,,Aspirin,,,,atherosclerosis,,,,, -26396469,446,,affects,,Aspirin,,,,Dysmenorrhea,,,,, -25760183,447,,affects,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -24559876,448,,affects,,Aspirin,,,,coronary artery disorder,,,,, -23119254,449,,affects,,Aspirin,,,,brain aneurysm,,,,, -21758599,450,,affects,,Aspirin,,,,brain aneurysm,,,,, -21116359,451,,affects,,Aspirin,,,,major depressive disorder,,,,, -21116358,452,,affects,,Aspirin,,,,schizophrenia,,,,, -21031382,453,,affects,,Aspirin,,,,neoplasm,,,,, -20857373,454,,affects,,Aspirin,,,,melanoma,,,,, -20741170,455,,affects,,Aspirin,,,,fetal growth restriction,,,,, -20453126,456,,affects,,Aspirin,,,,squamous cell carcinoma,,,,, -19190473,457,,affects,,Aspirin,,,,acute lung injury,,,,, -18874269,458,,affects,,Aspirin,,,,preeclampsia,,,,, -18830463,459,,affects,,Aspirin,,,,Varicose Ulcer,,,,, -18706529,460,,affects,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, -18617993,461,,affects,,Aspirin,,,,Sepsis,,,,, -18348076,462,,affects,,Aspirin,,,,Headache,,,,, -18344374,463,,affects,,Aspirin,,,,bone fracture,,,,, -18277701,464,,affects,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, -18092588,465,,affects,,Aspirin,,,,Fever,,,,, -17810437,466,,affects,,Aspirin,,,,migraine disorder,,,,, -16655533,467,,affects,,Aspirin,,,,stroke disorder,,,,, -16466986,468,,affects,,Aspirin,,,,myocardial ischemia,,,,, -16123563,469,,affects,,Aspirin,,,,digestive system disorder,,,,, -15829936,470,,affects,,Aspirin,,,,hypertriglyceridemia,,,,, -15667690,471,,affects,,Aspirin,,,,hepatocellular carcinoma,,,,, -15311732,472,,affects,,Aspirin,,,,periodontitis,,,,, -15094783,473,,affects,,Aspirin,,,,diabetic retinopathy,,,,, -13831910,474,,affects,,Aspirin,,,,gastric ulcer,,,,, -13734334,475,,affects,,Aspirin,,,,Pregnancy,,,,, -13647977,476,,affects,,Aspirin,,,,neoplasm,,,,, -13624111,477,,affects,,Aspirin,,,,pneumonia,,,,, -13559011,478,,affects,,Aspirin,,,,type 2 diabetes mellitus,,,,, -13493823,479,,affects,,Aspirin,,,,thrombotic disease,,,,, -12884495,480,,affects,,Aspirin,,,,duodenal ulcer,,,,, -12815469,481,,affects,,Aspirin,,,,atherosclerosis,,,,, -12769418,482,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, -12607959,483,,affects,,Aspirin,,,,plasma cell myeloma,,,,, -12446363,484,,affects,,Aspirin,,,,hypertensive disorder,,,,, -12124867,485,,affects,,Aspirin,,,,heart disorder,,,,, -11661767,486,,affects,,Aspirin,,,,peptic ulcer disease,,,,, -11474111,487,,affects,,Aspirin,,,,diabetes mellitus,,,,, -11357781,488,,affects,,Aspirin,,,,ischemic disease,,,,, -11341534,489,,affects,,Aspirin,,,,ulcer disease,,,,, -11135514,490,,affects,,Aspirin,,,,cerebrovascular disorder,,,,, -10875862,491,,affects,,Aspirin,,,,acquired polycythemia vera,,,,, -10830878,492,,affects,,Aspirin,,,,Inflammation,,,,, -10337669,493,,affects,,Aspirin,,,,colorectal neoplasm,,,,, -10331252,494,,affects,,Aspirin,,,,peptic ulcer disease,,,,, -10226347,495,,affects,,Aspirin,,,,thrombophilia,,,,, -10082315,496,,affects,,Aspirin,,,,Pain,,,,, -10068618,497,,affects,,Aspirin,,,,adenoma,,,,, -9766251,498,,affects,,Aspirin,,,,injury,,,,, -9581221,499,,affects,,Aspirin,,,,cataract,,,,, -9528323,500,,affects,,Aspirin,,,,asthma,,,,, -9510044,501,,affects,,Aspirin,,,,transient ischemic attack,,,,, -9342553,502,,affects,,Aspirin,,,,Salicylic Acid,,,,, -9259288,503,,affects,,Aspirin,,,,Fever,,,,, -9203900,504,,affects,,Aspirin,,,,Hypercholesterolemia,,,,, -9160463,505,,affects,,Aspirin,,,,gastric ulcer,,,,, -9084341,506,,affects,,Aspirin,,,,Ischemic stroke,,,,, -8650258,507,,affects,,Aspirin,,,,Hemorrhage,,,,, -8543326,508,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, -8290962,509,,affects,,Aspirin,,,,ulcer disease,,,,, -8187935,510,,affects,,Aspirin,,,,injury,,,,, -8173134,511,,affects,,Aspirin,,,,thrombotic disease,,,,, -8169760,512,,affects,,Aspirin,,,,preeclampsia,,,,, -7935107,513,,affects,,Aspirin,,,,prostate cancer,,,,, -7920712,514,,affects,,Aspirin,,,,Hemorrhage,,,,, -7876600,515,,affects,,Aspirin,,,,Hemorrhage,,,,, -7820545,516,,affects,,Aspirin,,,,vascular disorder,,,,, -7816175,517,,affects,,Aspirin,,,,Pregnancy,,,,, -7635677,518,,affects,,Aspirin,,,,myocardial ischemia,,,,, -7478885,519,,affects,,Aspirin,,,,coronary artery disorder,,,,, -7468514,520,,affects,,Aspirin,,,,stroke disorder,,,,, -7251569,521,,affects,,Aspirin,,,,myocardial infarction,,,,, -7213554,522,,affects,,Aspirin,,,,cardiovascular disorder,,,,, -7156429,523,,affects,,Aspirin,,,,Inflammation,,,,, -14159165,524,,affects,,Aspirin,,,,Salicylic Acid,,,,, -27335099,525,,disrupts,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -24958273,526,,disrupts,,Aspirin,,,,Fever,,,,, -24520178,527,,disrupts,,Aspirin,,,,melanoma,,,,, -24047967,528,,disrupts,,Aspirin,,,,cardiovascular disorder,,,,, -22107293,529,,disrupts,,Aspirin,,,,atrial fibrillation,,,,, -22100738,530,,disrupts,,Aspirin,,,,fetal growth restriction,,,,, -22027792,531,,disrupts,,Aspirin,,,,venous thromboembolism,,,,, -21434441,532,,disrupts,,Aspirin,,,,thrombophilia,,,,, -20385507,533,,disrupts,,Aspirin,,,,essential thrombocythemia,,,,, -19437129,534,,disrupts,,Aspirin,,,,Sepsis,,,,, -19421638,535,,disrupts,,Aspirin,,,,pneumonia,,,,, -19318532,536,,disrupts,,Aspirin,,,,vascular disorder,,,,, -18604728,537,,disrupts,,Aspirin,,,,type 2 diabetes mellitus,,,,, -18599969,538,,disrupts,,Aspirin,,,,arthritic joint disease,,,,, -18445880,539,,disrupts,,Aspirin,,,,ovarian cancer,,,,, -18225861,540,,disrupts,,Aspirin,,,,Hemorrhage,,,,, -18203584,541,,disrupts,,Aspirin,,,,brain aneurysm,,,,, -17476286,542,,disrupts,,Aspirin,,,,Fatigue,,,,, -17225706,543,,disrupts,,Aspirin,,,,transient ischemic attack,,,,, -16676314,544,,disrupts,,Aspirin,,,,ulcer disease,,,,, -16484307,545,,disrupts,,Aspirin,,,,acute lung injury,,,,, -14296080,546,,disrupts,,Aspirin,,,,Pregnancy,,,,, -14068900,547,,disrupts,,Aspirin,,,,active peptic ulcer disease,,,,, -13892678,548,,disrupts,,Aspirin,,,,breast neoplasm,,,,, -13449558,549,,disrupts,,Aspirin,,,,colorectal neoplasm,,,,, -12947740,550,,disrupts,,Aspirin,,,,diabetic retinopathy,,,,, -12815470,551,,disrupts,,Aspirin,,,,atherosclerosis,,,,, -12714476,552,,disrupts,,Aspirin,,,,cataract,,,,, -12478523,553,,disrupts,,Aspirin,,,,preeclampsia,,,,, -12450426,554,,disrupts,,Aspirin,,,,Barrett esophagus,,,,, -12023670,555,,disrupts,,Aspirin,,,,hypertensive disorder,,,,, -11827133,556,,disrupts,,Aspirin,,,,diabetes mellitus,,,,, -10318928,557,,disrupts,,Aspirin,,,,Myalgia,,,,, -9742254,558,,disrupts,,Aspirin,,,,adenoma,,,,, -9148614,559,,disrupts,,Aspirin,,,,neoplasm,,,,, -8526818,560,,disrupts,,Aspirin,,,,myocardial infarction,,,,, -7995298,561,,disrupts,,Aspirin,,,,Inflammation,,,,, -7878103,562,,disrupts,,Aspirin,,,,prostate cancer,,,,, -7775480,563,,disrupts,,Aspirin,,,,Pain,,,,, -7723340,564,,disrupts,,Aspirin,,,,stroke disorder,,,,, -7712646,565,,disrupts,,Aspirin,,,,coronary artery disorder,,,,, -7261879,566,,disrupts,,Aspirin,,,,thrombotic disease,,,,, -24597938,567,,prevents,,Aspirin,,,,thrombophilia,,,,, -24091248,568,,prevents,,Aspirin,,,,disseminated intravascular coagulation,,,,, -24015329,569,,prevents,,Aspirin,,,,neoplasm of esophagus,,,,, -23042755,570,,prevents,,Aspirin,,,,brain aneurysm,,,,, -22291835,571,,prevents,,Aspirin,,,,Hemorrhage,,,,, -21962376,572,,prevents,,Aspirin,,,,venous thromboembolism,,,,, -21587985,573,,prevents,,Aspirin,,,,blood coagulation disease,,,,, -21116357,574,,prevents,,Aspirin,,,,schizophrenia,,,,, -20356983,575,,prevents,,Aspirin,,,,acute lung injury,,,,, -20189716,576,,prevents,,Aspirin,,,,brain infarction,,,,, -18414184,577,,prevents,,Aspirin,,,,multiple sclerosis,,,,, -18344373,578,,prevents,,Aspirin,,,,bone fracture,,,,, -17911903,579,,prevents,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, -17240995,580,,prevents,,Aspirin,,,,hepatocellular carcinoma,,,,, -16163718,581,,prevents,,Aspirin,,,,Sepsis,,,,, -15608454,582,,prevents,,Aspirin,,,,squamous cell carcinoma,,,,, -14796348,583,,prevents,,Aspirin,,,,arthritic joint disease,,,,, -14183452,584,,prevents,,Aspirin,,,,pneumonia,,,,, -13992680,585,,prevents,,Aspirin,,,,diabetes mellitus,,,,, -13992679,586,,prevents,,Aspirin,,,,type 2 diabetes mellitus,,,,, -13770407,587,,prevents,,Aspirin,,,,diabetic retinopathy,,,,, -13624060,588,,prevents,,Aspirin,,,,injury,,,,, -13536062,589,,prevents,,Aspirin,,,,non-small cell lung carcinoma,,,,, -13041448,590,,prevents,,Aspirin,,,,atrial fibrillation,,,,, -12791249,591,,prevents,,Aspirin,,,,asthma,,,,, -12594676,592,,prevents,,Aspirin,,,,Fatigue,,,,, -12361944,593,,prevents,,Aspirin,,,,active peptic ulcer disease,,,,, -12273189,594,,prevents,,Aspirin,,,,Myalgia,,,,, -11593026,595,,prevents,,Aspirin,,,,colorectal neoplasm,,,,, -11289178,596,,prevents,,Aspirin,,,,migraine disorder,,,,, -11042545,597,,prevents,,Aspirin,,,,Barrett esophagus,,,,, -10366572,598,,prevents,,Aspirin,,,,cerebrovascular disorder,,,,, -10293726,599,,prevents,,Aspirin,,,,prostate cancer,,,,, -10185706,600,,prevents,,Aspirin,,,,colonic neoplasm,,,,, -10099399,601,,prevents,,Aspirin,,,,atherosclerosis,,,,, -10096705,602,,prevents,,Aspirin,,,,cerebral infarction,,,,, -10004143,603,,prevents,,Aspirin,,,,blindness (disorder),,,,, -9665356,604,,prevents,,Aspirin,,,,hypertensive disorder,,,,, -9388878,605,,prevents,,Aspirin,,,,coronary artery disorder,,,,, -9150304,606,,prevents,,Aspirin,,,,habitual spontaneous abortion,,,,, -8853513,607,,prevents,,Aspirin,,,,gastric ulcer,,,,, -8755758,608,,prevents,,Aspirin,,,,vascular disorder,,,,, -8494726,609,,prevents,,Aspirin,,,,ulcer disease,,,,, -8347839,610,,prevents,,Aspirin,,,,peptic ulcer disease,,,,, -8325441,611,,prevents,,Aspirin,,,,ischemic disease,,,,, -7877588,612,,prevents,,Aspirin,,,,cardiovascular disorder,,,,, -7852267,613,,prevents,,Aspirin,,,,Headache,,,,, -7716613,614,,prevents,,Aspirin,,,,neoplasm,,,,, -7603499,615,,prevents,,Aspirin,,,,myocardial ischemia,,,,, -7487700,616,,prevents,,Aspirin,,,,Inflammation,,,,, -7457050,617,,prevents,,Aspirin,,,,peripheral vascular disease,,,,, -7455467,618,,prevents,,Aspirin,,,,Ischemic stroke,,,,, -7455466,619,,prevents,,Aspirin,,,,stroke disorder,,,,, -7455465,620,,prevents,,Aspirin,,,,transient ischemic attack,,,,, -7419265,621,,prevents,,Aspirin,,,,heart disorder,,,,, -7368248,622,,prevents,,Aspirin,,,,thrombotic disease,,,,, -7317027,623,,prevents,,Aspirin,,,,preeclampsia,,,,, -7275741,624,,prevents,,Aspirin,,,,acute coronary syndrome,,,,, -7264064,625,,prevents,,Aspirin,,,,Pain,,,,, -7196018,626,,prevents,,Aspirin,,,,myocardial infarction,,,,, -7159192,627,,prevents,,Aspirin,,,,fetal growth restriction,,,,, -7110859,628,,prevents,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -22126985,629,,exacerbates,,Aspirin,,,,gastric ulcer,,,,, -21411566,630,,exacerbates,,Aspirin,,,,macular degeneration,,,,, -21359197,631,,exacerbates,,Aspirin,,,,acute coronary syndrome,,,,, -26115547,632,,predisposes,,Aspirin,,,,cerebral infarction,,,,, -25254777,633,,predisposes,,Aspirin,,,,essential thrombocythemia,,,,, -23315977,634,,predisposes,,Aspirin,,,,brain aneurysm,,,,, -21525767,635,,predisposes,,Aspirin,,,,Fever,,,,, -21487721,636,,predisposes,,Aspirin,,,,Hemorrhage,,,,, -20679052,637,,predisposes,,Aspirin,,,,blood coagulation disease,,,,, -20234206,638,,predisposes,,Aspirin,,,,hepatocellular carcinoma,,,,, -20155873,639,,predisposes,,Aspirin,,,,placental insufficiency,,,,, -19346376,640,,predisposes,,Aspirin,,,,chronic renal failure syndrome,,,,, -18235965,641,,predisposes,,Aspirin,,,,macular degeneration,,,,, -17872103,642,,predisposes,,Aspirin,,,,atrial fibrillation,,,,, -17123250,643,,predisposes,,Aspirin,,,,acute coronary syndrome,,,,, -16813141,644,,predisposes,,Aspirin,,,,melanoma,,,,, -16162173,645,,predisposes,,Aspirin,,,,ulcerative colitis,,,,, -15461534,646,,predisposes,,Aspirin,,,,gastric ulcer,,,,, -14856258,647,,predisposes,,Aspirin,,,,neoplasm of esophagus,,,,, -14426809,648,,predisposes,,Aspirin,,,,neoplasm,,,,, -14234947,649,,predisposes,,Aspirin,,,,diabetes mellitus,,,,, -14126301,650,,predisposes,,Aspirin,,,,cerebrovascular disorder,,,,, -14052964,651,,predisposes,,Aspirin,,,,Inflammation,,,,, -14015029,652,,predisposes,,Aspirin,,,,transient ischemic attack,,,,, -13644771,653,,predisposes,,Aspirin,,,,asthma,,,,, -13536064,654,,predisposes,,Aspirin,,,,non-small cell lung carcinoma,,,,, -13299957,655,,predisposes,,Aspirin,,,,ovarian cancer,,,,, -12673405,656,,predisposes,,Aspirin,,,,bone fracture,,,,, -12382415,657,,predisposes,,Aspirin,,,,colorectal neoplasm,,,,, -11071059,658,,predisposes,,Aspirin,,,,injury,,,,, -10962122,659,,predisposes,,Aspirin,,,,ischemic disease,,,,, -10547299,660,,predisposes,,Aspirin,,,,coronary artery disorder,,,,, -10337650,661,,predisposes,,Aspirin,,,,adenoma,,,,, -9857077,662,,predisposes,,Aspirin,,,,vascular disorder,,,,, -9535755,663,,predisposes,,Aspirin,,,,thrombotic disease,,,,, -9535754,664,,predisposes,,Aspirin,,,,hypertensive disorder,,,,, -9491661,665,,predisposes,,Aspirin,,,,cardiovascular disorder,,,,, -9477464,666,,predisposes,,Aspirin,,,,prostate cancer,,,,, -9404829,667,,predisposes,,Aspirin,,,,ulcer disease,,,,, -8850172,668,,predisposes,,Aspirin,,,,myocardial ischemia,,,,, -8763743,669,,predisposes,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, -8545255,670,,predisposes,,Aspirin,,,,Ischemic stroke,,,,, -7865543,671,,predisposes,,Aspirin,,,,Headache,,,,, -7858710,672,,predisposes,,Aspirin,,,,myocardial infarction,,,,, -7667039,673,,predisposes,,Aspirin,,,,preeclampsia,,,,, -7659453,674,,predisposes,,Aspirin,,,,stroke disorder,,,,, -7653535,675,,predisposes,,Aspirin,,,,peptic ulcer disease,,,,, -7596288,676,,predisposes,,Aspirin,,,,atherosclerosis,,,,, -7078619,677,,predisposes,,Aspirin,,,,active peptic ulcer disease,,,,, -23297288,678,,prevents,,Vemurafenib,,,,neoplasm,,,,, -22851133,679,,related to,,Dabrafenib,,,,melanoma,,,,, -18622575,680,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -18622575,681,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -26359747,682,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -26359747,683,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -24697302,684,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -24697302,685,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -10513644,686,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -10513644,687,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -15306394,688,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -15306394,689,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -10518221,690,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -9906740,691,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -8278260,692,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -9085295,693,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, -25915149,694,,related to,,Sodium monofluorophosphate,,,,dental caries,,,,, -25861359,695,,disrupts,,Sodium monofluorophosphate,,,,allergic disease,,,,, -19241020,696,,related to,,Sodium Fluoride,,,,gingivitis,,,,, -17448182,697,,related to,,Sodium Fluoride,,,,aortic valve stenosis,,,,, -9111981,698,,related to,,Sodium Fluoride,,,,dental caries,,,,, -25583763,699,,causes,,Sodium Fluoride,,,,dental fluorosis,,,,, -23780312,700,,affects,,Sodium Fluoride,,,,dental caries,,,,, -18846793,701,,affects,,Sodium Fluoride,,,,allergic disease,,,,, -25986070,702,,disrupts,,Sodium Fluoride,,,,allergic disease,,,,, -14286543,703,,prevents,,Sodium Fluoride,,,,gingivitis,,,,, -10538561,704,,prevents,,Sodium Fluoride,,,,periodontal disorder,,,,, -10425615,705,,prevents,,Sodium Fluoride,,,,dental caries,,,,, -19971424,706,,related to,,Rifaximin,,,,irritable bowel syndrome,,,,, -17053293,707,,related to,,Rifaximin,,,,hepatic encephalopathy,,,,, -18714048,708,,causes,,Rifaximin,,,,irritable bowel syndrome,,,,, -8925773,709,,causes,,Rifaximin,,,,diarrheal disease,,,,, -25434952,710,,affects,,Rifaximin,,,,alcoholic hepatitis,,,,, -24257624,711,,affects,,Rifaximin,,,,Infection,,,,, -20149851,712,,affects,,Rifaximin,,,,Crohn disease,,,,, -19665399,713,,affects,,Rifaximin,,,,diverticulitis,,,,, -18685028,714,,affects,,Rifaximin,,,,irritable bowel syndrome,,,,, -16575444,715,,affects,,Rifaximin,,,,hepatic encephalopathy,,,,, -21278571,716,,prevents,,Rifaximin,,,,alcoholic hepatitis,,,,, -16143515,717,,prevents,,Rifaximin,,,,diverticulitis,,,,, -15134586,718,,prevents,,Rifaximin,,,,hepatic encephalopathy,,,,, -11830138,719,,prevents,,Rifaximin,,,,irritable bowel syndrome,,,,, -11830137,720,,prevents,,Rifaximin,,,,diarrheal disease,,,,, -15717459,721,,predisposes,,Rifaximin,,,,hepatic encephalopathy,,,,, -25706307,722,,related to,,Glycine,,,,cystic fibrosis,,,,, -20102524,723,,related to,,Glycine,,,,psychotic disorder,,,,, -17514096,724,,related to,,Glycine,,,,hypertensive disorder,,,,, -13080824,725,,related to,,Glycine,,,,Alzheimer disease,,,,, -12589996,726,,related to,,Glycine,,,,nutritional disorder,,,,, -7298031,727,,related to,,Glycine,,,,schizophrenia,,,,, -17397486,728,,causes,,Glycine,,,,Cognitive impairment,,,,, -17125423,729,,affects,,Glycine,,,,asthma,,,,, -7530162,730,,affects,,Glycine,,,,schizophrenia,,,,, -12589998,731,,produces,,Glycine,,,,nutritional disorder,,,,, -16845009,732,,disrupts,,Glycine,,,,Alzheimer disease,,,,, -12278394,733,,prevents,,Glycine,,,,hypertensive disorder,,,,, -15546112,734,,predisposes,,Glycine,,,,asthma,,,,, -16711324,735,,related to,,Sorbitol,,,,injury,,,,, -10684679,736,,related to,,Sorbitol,,,,constipation disorder,,,,, -20821510,737,,causes,,Sorbitol,,,,constipation disorder,,,,, -15564538,738,,causes,,Sorbitol,,,,injury,,,,, -17658899,739,,affects,,Sorbitol,,,,osteoarthritis,,,,, -26106951,740,,prevents,,Sorbitol,,,,injury,,,,, -10478248,741,,affects,,Foscarnet,,,,cytomegalovirus infection,,,,, -10481132,742,,prevents,,Foscarnet,,,,cytomegalovirus infection,,,,, -22857734,743,,prevents,,Atogepant,,,,migraine disorder,,,,, -25325960,744,,prevents,,Rimegepant,,,,migraine disorder,,,,, -21939131,745,,prevents,,Rimegepant,,,,Pain,,,,, -10553741,746,,related to,,ATROPINE,,,,poisoning,,,,, -19468294,747,,causes,,ATROPINE,,,,Pain,,,,, -18989245,748,,causes,,ATROPINE,,,,digestive system disorder,,,,, -14576640,749,,causes,,ATROPINE,,,,myopia,,,,, -10716177,750,,causes,,ATROPINE,,,,Mydriasis,,,,, -10361041,751,,causes,,ATROPINE,,,,amblyopia,,,,, -9746341,752,,causes,,ATROPINE,,,,poisoning,,,,, -9301311,753,,causes,,ATROPINE,,,,cardiac arrest,,,,, -8524259,754,,causes,,ATROPINE,,,,Insulin resistance,,,,, -8480152,755,,causes,,ATROPINE,,,,Bradycardia,,,,, -26343406,756,,affects,,ATROPINE,,,,hypoglycemia,,,,, -23118209,757,,affects,,ATROPINE,,,,Mydriasis,,,,, -19520979,758,,affects,,ATROPINE,,,,hypoglycemia,,,,, -12406813,759,,affects,,ATROPINE,,,,cardiac arrest,,,,, -11741867,760,,affects,,ATROPINE,,,,Bradycardia,,,,, -10264479,761,,affects,,ATROPINE,,,,Hemorrhage,,,,, -9293832,762,,affects,,ATROPINE,,,,poisoning,,,,, -9041302,763,,affects,,ATROPINE,,,,Bradycardia,,,,, -7845760,764,,affects,,ATROPINE,,,,Bradycardia,,,,, -7111083,765,,affects,,ATROPINE,,,,myopia,,,,, -26141463,766,,disrupts,,ATROPINE,,,,hypoglycemia,,,,, -23143978,767,,disrupts,,ATROPINE,,,,poisoning,,,,, -20133204,768,,disrupts,,ATROPINE,,,,Pain,,,,, -18168420,769,,disrupts,,ATROPINE,,,,Bradycardia,,,,, -7111084,770,,disrupts,,ATROPINE,,,,myopia,,,,, -9676858,771,,prevents,,ATROPINE,,,,poisoning,,,,, -9198373,772,,prevents,,ATROPINE,,,,myopia,,,,, -8451883,773,,prevents,,ATROPINE,,,,cardiac arrest,,,,, -23699298,774,,predisposes,,ATROPINE,,,,myopia,,,,, -14640163,775,,predisposes,,ATROPINE,,,,poisoning,,,,, -7953996,776,,affects,,Tolcapone,,,,Parkinson disease,,,,, -15643297,777,,related to,,Entacapone,,,,Parkinson disease,,,,, -10033650,778,,causes,,Entacapone,,,,Parkinson disease,,,,, -15952178,779,,affects,,Entacapone,,,,Parkinson disease,,,,, -20308336,780,,disrupts,,Entacapone,,,,Parkinson disease,,,,, -25394620,781,,affects,,Veliparib,,,,neoplasm,,,,, -21697473,782,,affects,,Veliparib,,,,triple-negative breast carcinoma,,,,, -21882624,783,,causes,,Talazoparib,,,,neoplasm,,,,, -22572154,784,,affects,,Talazoparib,,,,neoplasm,,,,, -21697476,785,,affects,,Talazoparib,,,,triple-negative breast carcinoma,,,,, -22916819,786,,prevents,,Talazoparib,,,,neoplasm,,,,, -24451977,787,,related to,,Olaparib,,,,triple-negative breast carcinoma,,,,, -25473017,788,,causes,,Olaparib,,,,pancreatic ductal adenocarcinoma,,,,, -25473016,789,,causes,,Olaparib,,,,non-small cell lung carcinoma,,,,, -22160122,790,,causes,,Olaparib,,,,head and neck neoplasm,,,,, -24770500,791,,affects,,Olaparib,,,,castration-resistant prostate carcinoma,,,,, -24672020,792,,affects,,Olaparib,,,,prostate cancer,,,,, -22977330,793,,affects,,Olaparib,,,,neoplasm,,,,, -21697474,794,,affects,,Olaparib,,,,triple-negative breast carcinoma,,,,, -24201965,795,,prevents,,Olaparib,,,,Neoplasm Metastasis,,,,, -27698235,796,,related to,,Capsaicin,,,,arthritic joint disease,,,,, -22276323,797,,related to,,Capsaicin,,,,herpes zoster,,,,, -13200623,798,,related to,,Capsaicin,,,,migraine disorder,,,,, -11537529,799,,related to,,Capsaicin,,,,Cough,,,,, -10028696,800,,related to,,Capsaicin,,,,diabetic neuropathy,,,,, -8608120,801,,related to,,Capsaicin,,,,osteoarthritis,,,,, -8470968,802,,related to,,Capsaicin,,,,postherpetic neuralgia,,,,, -8246278,803,,related to,,Capsaicin,,,,neuralgia,,,,, -7965643,804,,related to,,Capsaicin,,,,Pruritus,,,,, -7239245,805,,related to,,Capsaicin,,,,Pain,,,,, -26554289,806,,causes,,Capsaicin,,,,stroke disorder,,,,, -24505933,807,,causes,,Capsaicin,,,,Muscle spasm,,,,, -18391785,808,,causes,,Capsaicin,,,,neuralgia,,,,, -16420383,809,,causes,,Capsaicin,,,,migraine disorder,,,,, -11163813,810,,causes,,Capsaicin,,,,arthritic joint disease,,,,, -9650510,811,,causes,,Capsaicin,,,,Myalgia,,,,, -8975038,812,,causes,,Capsaicin,,,,Vomiting,,,,, -8261437,813,,causes,,Capsaicin,,,,Cough,,,,, -7430731,814,,causes,,Capsaicin,,,,Pruritus,,,,, -7414435,815,,causes,,Capsaicin,,,,Pain,,,,, -27524804,816,,affects,,Capsaicin,,,,arthritic joint disease,,,,, -25438971,817,,affects,,Capsaicin,,,,brain injury,,,,, -19404541,818,,affects,,Capsaicin,,,,neuroma,,,,, -15791019,819,,affects,,Capsaicin,,,,Pruritus,,,,, -10951234,820,,affects,,Capsaicin,,,,stroke disorder,,,,, -10764355,821,,affects,,Capsaicin,,,,Pain,,,,, -10290167,822,,affects,,Capsaicin,,,,Pruritus,,,,, -10171204,823,,affects,,Capsaicin,,,,neuralgia,,,,, -8975035,824,,affects,,Capsaicin,,,,Vomiting,,,,, -8515286,825,,affects,,Capsaicin,,,,Pain,,,,, -8515285,826,,affects,,Capsaicin,,,,postherpetic neuralgia,,,,, -8441743,827,,affects,,Capsaicin,,,,Cough,,,,, -7281158,828,,affects,,Capsaicin,,,,Cough,,,,, -18283970,829,,disrupts,,Capsaicin,,,,Pain,,,,, -17652809,830,,disrupts,,Capsaicin,,,,arthritic joint disease,,,,, -14643733,831,,disrupts,,Capsaicin,,,,breast neoplasm,,,,, -9869751,832,,disrupts,,Capsaicin,,,,Cough,,,,, -8160008,833,,disrupts,,Capsaicin,,,,Pruritus,,,,, -25438980,834,,prevents,,Capsaicin,,,,brain injury,,,,, -20404597,835,,prevents,,Capsaicin,,,,postherpetic neuralgia,,,,, -17168513,836,,prevents,,Capsaicin,,,,migraine disorder,,,,, -16978917,837,,prevents,,Capsaicin,,,,neuralgia,,,,, -15822967,838,,prevents,,Capsaicin,,,,stroke disorder,,,,, -10290168,839,,prevents,,Capsaicin,,,,Pruritus,,,,, -8608117,840,,prevents,,Capsaicin,,,,osteoarthritis,,,,, -8246280,841,,prevents,,Capsaicin,,,,Pain,,,,, -14706687,842,,predisposes,,Capsaicin,,,,Pain,,,,, -24021484,843,,causes,,Nusinersen,,,,spinal muscular atrophy,,,,, -22907909,844,,affects,,Nusinersen,,,,spinal muscular atrophy,,,,, -27681284,845,,related to,,Hyaluronic acid sodium salt,,,,alcoholic hepatitis,,,,, -26794689,846,,related to,,Hyaluronic acid sodium salt,,,,carpal tunnel syndrome,,,,, -20903427,847,,related to,,Hyaluronic acid sodium salt,,,,Skin ulcer,,,,, -18915649,848,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -18915649,849,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -15362486,850,,related to,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, -14268478,851,,related to,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, -9147590,852,,related to,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, -7458117,853,,related to,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -17074499,854,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -17074499,855,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -12401778,856,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -12401778,857,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -11319224,858,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -11319224,859,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -7287149,860,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -7699622,861,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -12146167,862,,causes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -8938037,863,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -8541022,864,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -7683831,865,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -7895314,866,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -18839068,867,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -18839068,868,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -9813251,869,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -9813251,870,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -17165364,871,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -17165364,872,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, -23839601,873,,disrupts,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, -22764727,874,,disrupts,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, -7155073,875,,disrupts,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -18262848,876,,prevents,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, -11511344,877,,prevents,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -21264578,878,,predisposes,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, -11605823,879,,predisposes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, -24659748,880,,related to,,Zoledronic acid,,,,osteoporosis,,,,, -18902207,881,,causes,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, -18856931,882,,causes,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, -13083414,883,,causes,,Zoledronic acid,,,,bone fracture,,,,, -21044659,884,,affects,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, -19059032,885,,affects,,Zoledronic acid,,,,bone osteosarcoma,,,,, -13892047,886,,affects,,Zoledronic acid,,,,bone fracture,,,,, -13448998,887,,affects,,Zoledronic acid,,,,osteonecrosis,,,,, -9617769,888,,affects,,Zoledronic acid,,,,osteoporosis,,,,, -24472422,889,,disrupts,,Zoledronic acid,,,,sarcoma,,,,, -20879055,890,,disrupts,,Zoledronic acid,,,,Neoplasm Metastasis,,,,, -20879053,891,,disrupts,,Zoledronic acid,,,,Pain,,,,, -13311906,892,,disrupts,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, -9617771,893,,disrupts,,Zoledronic acid,,,,bone fracture,,,,, -22662537,894,,prevents,,Zoledronic acid,,,,osteoporosis,,,,, -20148397,895,,prevents,,Zoledronic acid,,,,osteonecrosis,,,,, -13621414,896,,prevents,,Zoledronic acid,,,,bone fracture,,,,, -12127006,897,,prevents,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, -20851623,898,,predisposes,,Zoledronic acid,,,,bone fracture,,,,, -15272127,899,,predisposes,,Zoledronic acid,,,,osteonecrosis,,,,, -14006582,900,,prevents,,Risedronic acid,,,,osteoporosis,,,,, -17290459,901,,affects,,IBANDRONIC ACID,,,,osteonecrosis,,,,, -9797983,902,,affects,,IBANDRONIC ACID,,,,Neoplasm Metastasis,,,,, -15290649,903,,prevents,,IBANDRONIC ACID,,,,bone disorder,,,,, -13697992,904,,prevents,,IBANDRONIC ACID,,,,Pain,,,,, -10307139,905,,prevents,,IBANDRONIC ACID,,,,postmenopausal osteoporosis,,,,, -10028971,906,,prevents,,IBANDRONIC ACID,,,,osteoporosis,,,,, -18363632,907,,predisposes,,IBANDRONIC ACID,,,,Abdominal pain,,,,, -9434475,908,,predisposes,,IBANDRONIC ACID,,,,osteoporosis,,,,, -17514758,909,,related to,,Alendronic acid,,,,osteoarthritis,,,,, -14283477,910,,related to,,Alendronic acid,,,,osteoporosis,,,,, -11575454,911,,related to,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -14254304,912,,causes,,Alendronic acid,,,,asthma,,,,, -14049757,913,,causes,,Alendronic acid,,,,osteoporosis,,,,, -11710947,914,,causes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -25124892,915,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -24296937,916,,affects,,Alendronic acid,,,,bone disorder,,,,, -17701514,917,,affects,,Alendronic acid,,,,osteoarthritis,,,,, -14769549,918,,affects,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -12316243,919,,affects,,Alendronic acid,,,,osteoporosis,,,,, -12136907,920,,affects,,Alendronic acid,,,,periodontitis,,,,, -8809813,921,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -22627610,922,,disrupts,,Alendronic acid,,,,aortic valve stenosis,,,,, -17047070,923,,disrupts,,Alendronic acid,,,,prostate cancer,,,,, -9109277,924,,disrupts,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -8466156,925,,disrupts,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -24628288,926,,prevents,,Alendronic acid,,,,osteoarthritis,,,,, -15290647,927,,prevents,,Alendronic acid,,,,bone disorder,,,,, -7495571,928,,prevents,,Alendronic acid,,,,osteoporosis,,,,, -7314446,929,,prevents,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -7150371,930,,prevents,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, -25381093,931,,predisposes,,Alendronic acid,,,,osteoporosis,,,,, -22975353,932,,predisposes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, -12652815,933,,related to,,Pamidronic acid,,,,osteoporosis,,,,, -7541169,934,,related to,,Pamidronic acid,,,,plasma cell myeloma,,,,, -12040766,935,,affects,,Pamidronic acid,,,,plasma cell myeloma,,,,, -10860757,936,,affects,,Pamidronic acid,,,,osteoporosis,,,,, -9170219,937,,prevents,,Pamidronic acid,,,,osteoporosis,,,,, -9315699,938,,prevents,,Octyl methoxycinnamate,,,,sunburn,,,,, -10529058,939,,coexists with,,4-Aminobenzoic acid,,,,Procaine,,,,, -25771688,940,,causes,,Nitrazepam,,,,epilepsy,,,,, -19206956,941,,affects,,Nitrazepam,,,,depressive disorder,,,,, -25737609,942,,disrupts,,Nitrazepam,,,,epilepsy,,,,, -7322742,943,,prevents,,Nitrazepam,,,,epilepsy,,,,, -25779340,944,,causes,,Flurazepam,,,,depressive disorder,,,,, -19092155,945,,causes,,Triazolam,,,,depressive disorder,,,,, -16852864,946,,causes,,Triazolam,,,,insomnia,,,,, -27224077,947,,affects,,Triazolam,,,,insomnia,,,,, -15159227,948,,disrupts,,Triazolam,,,,anxiety,,,,, -24702695,949,,related to,,Midazolam,,,,delirium,,,,, -16327495,950,,related to,,Midazolam,,,,obesity disorder,,,,, -17503618,951,,causes,,Midazolam,,,,Nausea,,,,, -13087342,952,,causes,,Midazolam,,,,status epilepticus,,,,, -12880145,953,,causes,,Midazolam,,,,delirium,,,,, -12134398,954,,causes,,Midazolam,,,,brain injury,,,,, -11162624,955,,causes,,Midazolam,,,,Pain,,,,, -10221339,956,,causes,,Midazolam,,,,injury,,,,, -10197463,957,,causes,,Midazolam,,,,epilepsy,,,,, -7739374,958,,causes,,Midazolam,,,,hypotensive disorder,,,,, -7211473,959,,causes,,Midazolam,,,,depressive disorder,,,,, -7104276,960,,causes,,Midazolam,,,,dissociative amnesia,,,,, -27271852,961,,affects,,Midazolam,,,,Pruritus,,,,, -26121850,962,,affects,,Midazolam,,,,Pain,,,,, -25522494,963,,affects,,Midazolam,,,,anxiety,,,,, -22514965,964,,affects,,Midazolam,,,,anxiety,,,,, -22203290,965,,affects,,Midazolam,,,,post-traumatic stress disorder,,,,, -21411467,966,,affects,,Midazolam,,,,Suicidal ideation,,,,, -20820424,967,,affects,,Midazolam,,,,injury,,,,, -20230773,968,,affects,,Midazolam,,,,hypotensive disorder,,,,, -19683992,969,,affects,,Midazolam,,,,injury,,,,, -18986257,970,,affects,,Midazolam,,,,neoplasm,,,,, -18893940,971,,affects,,Midazolam,,,,hypertensive disorder,,,,, -18670184,972,,affects,,Midazolam,,,,hypotensive disorder,,,,, -18644607,973,,affects,,Midazolam,,,,neuralgia,,,,, -18331473,974,,affects,,Midazolam,,,,status epilepticus,,,,, -17655582,975,,affects,,Midazolam,,,,Cough,,,,, -12605496,976,,affects,,Midazolam,,,,dissociative amnesia,,,,, -12154940,977,,affects,,Midazolam,,,,Nausea,,,,, -11981571,978,,affects,,Midazolam,,,,delirium,,,,, -8867560,979,,affects,,Midazolam,,,,Pain,,,,, -8871799,980,,affects,,Midazolam,,,,hypotensive disorder,,,,, -8701804,981,,affects,,Midazolam,,,,epilepsy,,,,, -8569605,982,,affects,,Midazolam,,,,brain injury,,,,, -7116661,983,,affects,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, -20025306,984,,disrupts,,Midazolam,,,,Pruritus,,,,, -18424847,985,,disrupts,,Midazolam,,,,status epilepticus,,,,, -16150704,986,,disrupts,,Midazolam,,,,Cough,,,,, -14733481,987,,disrupts,,Midazolam,,,,neuralgia,,,,, -13861580,988,,disrupts,,Midazolam,,,,Pain,,,,, -9443524,989,,disrupts,,Midazolam,,,,epilepsy,,,,, -7819099,990,,disrupts,,Midazolam,,,,anxiety,,,,, -21663738,991,,prevents,,Midazolam,,,,anxiety,,,,, -20820423,992,,prevents,,Midazolam,,,,injury,,,,, -17322994,993,,prevents,,Midazolam,,,,Aggressive behavior,,,,, -16397367,994,,prevents,,Midazolam,,,,status epilepticus,,,,, -13467675,995,,prevents,,Midazolam,,,,Nausea,,,,, -11373548,996,,prevents,,Midazolam,,,,Cough,,,,, -11041799,997,,prevents,,Midazolam,,,,bone fracture,,,,, -9493413,998,,prevents,,Midazolam,,,,epilepsy,,,,, -8653279,999,,prevents,,Midazolam,,,,Sepsis,,,,, -8569600,1000,,prevents,,Midazolam,,,,brain injury,,,,, -8151023,1001,,prevents,,Midazolam,,,,Pain,,,,, -7116663,1002,,prevents,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, -16657523,1003,,exacerbates,,Midazolam,,,,Sepsis,,,,, -19191198,1004,,predisposes,,Midazolam,,,,dissociative amnesia,,,,, -18422952,1005,,predisposes,,Midazolam,,,,status epilepticus,,,,, -11981572,1006,,predisposes,,Midazolam,,,,delirium,,,,, -22402246,1007,,disrupts,,Brotizolam,,,,anxiety,,,,, -12312025,1008,,related to,,Ganirelix,,,,polycystic ovary syndrome,,,,, -14831488,1009,,disrupts,,Cetrorelix,,,,benign prostatic hyperplasia,,,,, -18703871,1010,,prevents,,Cetrorelix,,,,endometriosis,,,,, -18874469,1011,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -18874469,1012,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -12069194,1013,,related to,,Methoxsalen,,,,mycosis fungoides,,,,, -8610329,1014,,related to,,Methoxsalen,,,,psoriasis,,,,, -26218137,1015,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -26218137,1016,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -7172075,1017,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -7172075,1018,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -26761340,1019,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -26761340,1020,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -7782040,1021,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -12022213,1022,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -9512596,1023,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -19709381,1024,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, -8674128,1025,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -8674128,1026,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -8674127,1027,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -25732039,1028,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -16826513,1029,,affects,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, -9717834,1030,,related to,,Bisoprolol,,,,hypertensive disorder,,,,, -17484309,1031,,affects,,Bisoprolol,,,,Hemorrhage,,,,, -14633716,1032,,affects,,Bisoprolol,,,,hypertensive disorder,,,,, -13150765,1033,,affects,,Bisoprolol,,,,pulmonary arterial hypertension,,,,, -24626572,1034,,disrupts,,Bisoprolol,,,,Hemorrhage,,,,, -23315135,1035,,prevents,,Bisoprolol,,,,Hemorrhage,,,,, -26817035,1036,,related to,,Esmolol,,,,atrial fibrillation,,,,, -13689489,1037,,causes,,Esmolol,,,,atrial fibrillation,,,,, -20072391,1038,,affects,,Esmolol,,,,toxic shock syndrome,,,,, -19519833,1039,,affects,,Esmolol,,,,Pain,,,,, -16877299,1040,,prevents,,Esmolol,,,,Pain,,,,, -10180097,1041,,prevents,,Esmolol,,,,ischemia reperfusion injury,,,,, -9581320,1042,,prevents,,Esmolol,,,,atrial fibrillation,,,,, -18235527,1043,,related to,,Oxygen,,,,pulmonary fibrosis,,,,, -18193743,1044,,related to,,Oxygen,,,,neoplasm,,,,, -17303485,1045,,related to,,Oxygen,,,,Hypoxemia,,,,, -14116536,1046,,related to,,Oxygen,,,,Shock,,,,, -13587155,1047,,related to,,Oxygen,,,,injury,,,,, -8813011,1048,,related to,,Oxygen,,,,ischemia reperfusion injury,,,,, -21893162,1049,,causes,,Oxygen,,,,neoplasm,,,,, -19992109,1050,,causes,,Oxygen,,,,ischemia reperfusion injury,,,,, -8243272,1051,,causes,,Oxygen,,,,vascular disorder,,,,, -8114891,1052,,causes,,Oxygen,,,,injury,,,,, -7992845,1053,,causes,,Oxygen,,,,Hypoxemia,,,,, -7752235,1054,,causes,,Oxygen,,,,stroke disorder,,,,, -23272853,1055,,affects,,Oxygen,,,,neoplasm,,,,, -22206348,1056,,affects,,Oxygen,,,,neoplasm,,,,, -19397332,1057,,affects,,Oxygen,,,,Hypoxemia,,,,, -13060611,1058,,affects,,Oxygen,,,,Shock,,,,, -13638133,1059,,produces,,Oxygen,,,,Hypoxemia,,,,, -13264427,1060,,produces,,Oxygen,,,,neoplasm,,,,, -12483211,1061,,disrupts,,Oxygen,,,,Hypoxemia,,,,, -11682185,1062,,disrupts,,Oxygen,,,,neoplasm,,,,, -16806319,1063,,prevents,,Oxygen,,,,injury,,,,, -17280500,1064,,predisposes,,Oxygen,,,,injury,,,,, -7575686,1065,,subclass of,,Metoprolol,,,,O-Demethylmetoprolol,,,,, -7575685,1066,,subclass of,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -27359356,1067,,related to,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -27639377,1068,,derives from,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -26548288,1069,,physically interacts with,,Metoprolol,,,,O-Demethylmetoprolol,,,,, -21656554,1070,,physically interacts with,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, -27101524,1071,,causes,,Metoprolol,,,,ventricular tachycardia,,,,, -27101519,1072,,causes,,Metoprolol,,,,ventricular fibrillation,,,,, -20648435,1073,,causes,,Metoprolol,,,,cardiac rhythm disease,,,,, -14625318,1074,,causes,,Metoprolol,,,,hypertensive disorder,,,,, -19013861,1075,,affects,,Metoprolol,,,,obesity disorder,,,,, -17630974,1076,,affects,,Metoprolol,,,,coronary artery disorder,,,,, -17630973,1077,,affects,,Metoprolol,,,,atherosclerosis,,,,, -16547648,1078,,affects,,Metoprolol,,,,myocardial infarction,,,,, -12751741,1079,,affects,,Metoprolol,,,,cardiac rhythm disease,,,,, -11341339,1080,,affects,,Metoprolol,,,,hypertensive disorder,,,,, -16802112,1081,,disrupts,,Metoprolol,,,,atrial fibrillation,,,,, -14314818,1082,,disrupts,,Metoprolol,,,,atherosclerosis,,,,, -13648308,1083,,disrupts,,Metoprolol,,,,ventricular tachycardia,,,,, -12510783,1084,,disrupts,,Metoprolol,,,,cardiac rhythm disease,,,,, -16624344,1085,,prevents,,Metoprolol,,,,cardiac rhythm disease,,,,, -13530896,1086,,prevents,,Metoprolol,,,,myocardial infarction,,,,, -13366014,1087,,prevents,,Metoprolol,,,,hypertensive disorder,,,,, -13268090,1088,,prevents,,Metoprolol,,,,ventricular fibrillation,,,,, -9428080,1089,,prevents,,Metoprolol,,,,atrial fibrillation,,,,, -7236533,1090,,prevents,,Metoprolol,,,,atherosclerosis,,,,, -22663349,1091,,predisposes,,Metoprolol,,,,atrial fibrillation,,,,, -25990864,1092,,affects,,Acebutolol,,,,hypertensive disorder,,,,, -25995365,1093,,prevents,,Acebutolol,,,,hypertensive disorder,,,,, -24856753,1094,,affects,,Pretomanid,,,,multidrug-resistant tuberculosis,,,,, -17848125,1095,,related to,,Nitrogen,,,,chronic obstructive pulmonary disease,,,,, -15192685,1096,,related to,,Nitrogen,,,,ischemia reperfusion injury,,,,, -10505101,1097,,related to,,Nitrogen,,,,burn,,,,, -10425490,1098,,related to,,Nitrogen,,,,cystic fibrosis,,,,, -16934805,1099,,causes,,Nitrogen,,,,ischemia reperfusion injury,,,,, -13030867,1100,,affects,,Nitrogen,,,,ischemia reperfusion injury,,,,, -9020164,1101,,affects,,Nitrogen,,,,severe acute respiratory syndrome,,,,, -17493096,1102,,predisposes,,Nitrogen,,,,ischemia reperfusion injury,,,,, -25313239,1103,,related to,,Helium,,,,status asthmaticus,,,,, -12274245,1104,,related to,,Helium,,,,chronic obstructive pulmonary disease,,,,, -15248421,1105,,related to,,Carbon Dioxide,,,,Pain,,,,, -11844945,1106,,related to,,Carbon Dioxide,,,,sleep apnea syndrome,,,,, -10575797,1107,,related to,,Carbon Dioxide,,,,respiratory failure,,,,, -7620110,1108,,related to,,Carbon Dioxide,,,,panic disorder,,,,, -16671036,1109,,causes,,Carbon Dioxide,,,,panic disorder,,,,, -11038318,1110,,causes,,Carbon Dioxide,,,,respiratory failure,,,,, -20071308,1111,,affects,,Carbon Dioxide,,,,Pain,,,,, -15771768,1112,,affects,,Carbon Dioxide,,,,Pain,,,,, -15385933,1113,,affects,,Carbon Dioxide,,,,panic disorder,,,,, -14460813,1114,,affects,,Carbon Dioxide,,,,respiratory failure,,,,, -15294247,1115,,produces,,Carbon Dioxide,,,,respiratory failure,,,,, -11946282,1116,,disrupts,,Carbon Dioxide,,,,Pain,,,,, -17126447,1117,,predisposes,,Carbon Dioxide,,,,Pain,,,,, -11404382,1118,,predisposes,,Carbon Dioxide,,,,panic disorder,,,,, -7432027,1119,,predisposes,,Carbon Dioxide,,,,respiratory failure,,,,, -24776228,1120,,causes,,Ethambutol,,,,tuberculosis,,,,, -25946331,1121,,affects,,Ethambutol,,,,tuberculosis,,,,, -24875144,1122,,affects,,Ethambutol,,,,pulmonary tuberculosis,,,,, -25597027,1123,,disrupts,,Ethambutol,,,,tuberculosis,,,,, -18704735,1124,,prevents,,Ethambutol,,,,tuberculosis,,,,, -14472959,1125,,affects,,Pyrazinamide,,,,pulmonary tuberculosis,,,,, -10149898,1126,,affects,,Pyrazinamide,,,,tuberculosis,,,,, -8080030,1127,,prevents,,Pyrazinamide,,,,tuberculosis,,,,, -27556045,1128,,predisposes,,Pyrazinamide,,,,tuberculosis,,,,, -26376727,1129,,related to,,Androstanolone,,,,hypogonadism,,,,, -22807780,1130,,affects,,Androstanolone,,,,hypogonadism,,,,, -7261548,1131,,related to,,Nebivolol,,,,essential hypertension,,,,, -10251853,1132,,affects,,Nebivolol,,,,hypertensive disorder,,,,, -20026875,1133,,prevents,,Nebivolol,,,,cardiovascular disorder,,,,, -10251855,1134,,prevents,,Nebivolol,,,,hypertensive disorder,,,,, -11558481,1135,,exacerbates,,Nebivolol,,,,hypertensive disorder,,,,, -17527026,1136,,related to,,Landiolol,,,,atrial fibrillation,,,,, -14267268,1137,,affects,,Landiolol,,,,atrial fibrillation,,,,, -16074351,1138,,disrupts,,Landiolol,,,,atrial fibrillation,,,,, -21882778,1139,,prevents,,Landiolol,,,,cardiac rhythm disease,,,,, -14873276,1140,,prevents,,Landiolol,,,,atrial fibrillation,,,,, -20190145,1141,,predisposes,,Landiolol,,,,atrial fibrillation,,,,, -26530979,1142,,related to,,Oxandrolone,,,,nutritional disorder,,,,, -17138340,1143,,related to,,Oxandrolone,,,,Fanconi anemia,,,,, -12117784,1144,,related to,,Oxandrolone,,,,Turner syndrome,,,,, -11269262,1145,,related to,,Oxandrolone,,,,burn,,,,, -7561027,1146,,causes,,Cefepime,,,,toxic shock syndrome,,,,, -19437692,1147,,affects,,Cefepime,,,,bacterial infectious disease,,,,, -17947468,1148,,affects,,Cefepime,,,,infectious disease,,,,, -19800344,1149,,disrupts,,Cefepime,,,,infectious disease,,,,, -26336145,1150,,related to,,Hydrocortisone butyrate,,,,"dermatitis, atopic",,,,, -26243703,1151,,related to,,Hydrocortisone butyrate,,,,skin disorder,,,,, -25968096,1152,,related to,,Hydrocortisone butyrate,,,,psoriasis,,,,, -17603464,1153,,disrupts,,Hydrocortisone butyrate,,,,psoriasis,,,,, -9729745,1154,,related to,,Adapalene,,,,acne,,,,, -8571018,1155,,physically interacts with,,Adapalene,,,,Retinoic Acid Receptor,,,,, -13523825,1156,,related to,,Retinol,,,,eye disorder,,,,, -11015290,1157,,related to,,Retinol,,,,tuberculosis,,,,, -10457909,1158,,related to,,Retinol,,,,acne,,,,, -8518043,1159,,related to,,Retinol,,,,malaria,,,,, -8137103,1160,,related to,,Retinol,,,,vitamin A deficiency,,,,, -7807614,1161,,related to,,Retinol,,,,retinitis pigmentosa,,,,, -9304322,1162,,causes,,Retinol,,,,malaria,,,,, -27090494,1163,,affects,,Retinol,,,,diarrheal disease,,,,, -21959378,1164,,affects,,Retinol,,,,nutritional disorder,,,,, -17401879,1165,,affects,,Retinol,,,,tuberculosis,,,,, -17082512,1166,,affects,,Retinol,,,,acne,,,,, -12962972,1167,,affects,,Retinol,,,,eye disorder,,,,, -12534891,1168,,affects,,Retinol,,,,vitamin A deficiency,,,,, -11508263,1169,,affects,,Retinol,,,,diarrheal disease,,,,, -10941106,1170,,affects,,Retinol,,,,vitamin A deficiency,,,,, -22325993,1171,,produces,,Retinol,,,,Infection,,,,, -23772860,1172,,disrupts,,Retinol,,,,vitamin A deficiency,,,,, -12105339,1173,,disrupts,,Retinol,,,,diarrheal disease,,,,, -24823924,1174,,prevents,,Retinol,,,,Infection,,,,, -17332605,1175,,prevents,,Retinol,,,,malaria,,,,, -11445573,1176,,prevents,,Retinol,,,,nutritional disorder,,,,, -8153477,1177,,prevents,,Retinol,,,,diarrheal disease,,,,, -23860384,1178,,predisposes,,Retinol,,,,nutritional disorder,,,,, -19923430,1179,,predisposes,,Retinol,,,,malaria,,,,, -16391363,1180,,predisposes,,Retinol,,,,tuberculosis,,,,, -15050082,1181,,predisposes,,Retinol,,,,diarrheal disease,,,,, -9744244,1182,,predisposes,,Retinol,,,,vitamin A deficiency,,,,, -18962170,1183,,related to,,Isotretinoin,,,,neuroblastoma,,,,, -16229483,1184,,related to,,Isotretinoin,,,,brain cancer,,,,, -15225681,1185,,related to,,Isotretinoin,,,,acne,,,,, -14091563,1186,,related to,,Isotretinoin,,,,myelodysplastic syndrome,,,,, -9061344,1187,,related to,,Isotretinoin,,,,renal cell carcinoma,,,,, -11768316,1188,,physically interacts with,,Isotretinoin,,,,Retinoic Acid Receptor,,,,, -21199868,1189,,causes,,Isotretinoin,,,,neuroblastoma,,,,, -19803622,1190,,causes,,Isotretinoin,,,,acne,,,,, -19310397,1191,,causes,,Isotretinoin,,,,breast neoplasm,,,,, -13522698,1192,,causes,,Isotretinoin,,,,neoplasm,,,,, -23934527,1193,,affects,,Isotretinoin,,,,neoplasm,,,,, -20382078,1194,,affects,,Isotretinoin,,,,neuroblastoma,,,,, -15927367,1195,,affects,,Isotretinoin,,,,rosacea,,,,, -15330626,1196,,affects,,Isotretinoin,,,,acne,,,,, -11212975,1197,,affects,,Isotretinoin,,,,neoplasm,,,,, -9764204,1198,,affects,,Isotretinoin,,,,acne,,,,, -21476432,1199,,disrupts,,Isotretinoin,,,,neuroblastoma,,,,, -14724193,1200,,disrupts,,Isotretinoin,,,,neoplasm,,,,, -14863864,1201,,prevents,,Isotretinoin,,,,acne,,,,, -8312321,1202,,prevents,,Isotretinoin,,,,neoplasm,,,,, -15444114,1203,,exacerbates,,Isotretinoin,,,,ichthyosis,,,,, -15310461,1204,,predisposes,,Isotretinoin,,,,acne,,,,, -24593446,1205,,affects,,Trifarotene,,,,acne,,,,, -21448312,1206,,affects,,Atazanavir,,,,AIDS,,,,, -24947472,1207,,disrupts,,Atazanavir,,,,HIV infectious disease,,,,, -13198660,1208,,disrupts,,Atazanavir,,,,AIDS,,,,, -20253995,1209,,prevents,,Atazanavir,,,,AIDS,,,,, -8134603,1210,,affects,,Saquinavir,,,,HIV infectious disease,,,,, -16320598,1211,,disrupts,,Saquinavir,,,,viral infectious disease,,,,, -13198658,1212,,disrupts,,Saquinavir,,,,AIDS,,,,, -17107608,1213,,prevents,,Saquinavir,,,,HIV infectious disease,,,,, -12560548,1214,,prevents,,Indinavir,,,,viral infectious disease,,,,, -15113750,1215,,related to,,Ritonavir,,,,AIDS,,,,, -7566746,1216,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -7566746,1217,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -15583404,1218,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -15583404,1219,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -11500913,1220,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -8329957,1221,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -8452370,1222,,causes,,Ritonavir,,,,AIDS,,,,, -21492333,1223,,affects,,Ritonavir,,,,neoplasm,,,,, -12140603,1224,,affects,,Ritonavir,,,,Insulin resistance,,,,, -9520105,1225,,affects,,Ritonavir,,,,HIV infectious disease,,,,, -7566745,1226,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -15873481,1227,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, -21820102,1228,,disrupts,,Ritonavir,,,,Coronavinae infectious disease,,,,, -15656958,1229,,disrupts,,Ritonavir,,,,HIV infectious disease,,,,, -9520113,1230,,disrupts,,Ritonavir,,,,neoplasm,,,,, -22737012,1231,,prevents,,Ritonavir,,,,neoplasm,,,,, -10934319,1232,,prevents,,Ritonavir,,,,Kaposi's sarcoma,,,,, -12915909,1233,,causes,,Nelfinavir,,,,diarrheal disease,,,,, -19184628,1234,,affects,,Nelfinavir,,,,neoplasm,,,,, -16087478,1235,,affects,,Nelfinavir,,,,plasma cell myeloma,,,,, -11272488,1236,,affects,,Nelfinavir,,,,diarrheal disease,,,,, -10940786,1237,,affects,,Thiopental,,,,brain injury,,,,, -7790675,1238,,prevents,,Thiopental,,,,brain injury,,,,, -26262897,1239,,causes,,Pentobarbital,,,,insomnia,,,,, -25778415,1240,,affects,,Pentobarbital,,,,insomnia,,,,, -13642757,1241,,disrupts,,Pentobarbital,,,,status epilepticus,,,,, -23761012,1242,,prevents,,Amobarbital,,,,osteoarthritis,,,,, -26983984,1243,,causes,,Moxisylyte,,,,erectile dysfunction,,,,, -26385811,1244,,prevents,,Mepyramine,,,,allergic disease,,,,, -27140633,1245,,subclass of,,Promethazine,,,,Promethazine sulfoxide,,,,, -19124534,1246,,related to,,Promethazine,,,,Vomiting,,,,, -26252918,1247,,causes,,Promethazine,,,,Vomiting,,,,, -8157500,1248,,causes,,Promethazine,,,,depressive disorder,,,,, -19547748,1249,,affects,,Promethazine,,,,Vomiting,,,,, -12404928,1250,,affects,,Promethazine,,,,Pruritus,,,,, -10742218,1251,,affects,,Promethazine,,,,Nausea,,,,, -10228295,1252,,affects,,Promethazine,,,,central nervous system origin vertigo,,,,, -7912966,1253,,affects,,Promethazine,,,,Vomiting,,,,, -13616931,1254,,disrupts,,Promethazine,,,,Nausea,,,,, -17497020,1255,,prevents,,Promethazine,,,,central nervous system origin vertigo,,,,, -11541778,1256,,prevents,,Promethazine,,,,Pruritus,,,,, -7912965,1257,,prevents,,Promethazine,,,,Vomiting,,,,, -7912964,1258,,prevents,,Promethazine,,,,Nausea,,,,, -25750000,1259,,causes,,Clemastine,,,,urticaria,,,,, -25747466,1260,,affects,,Clemastine,,,,urticaria,,,,, -19433677,1261,,affects,,Clemastine,,,,Pruritus,,,,, -25634655,1262,,disrupts,,Clemastine,,,,urticaria,,,,, -24612586,1263,,prevents,,Clemastine,,,,urticaria,,,,, -17916924,1264,,prevents,,Clemastine,,,,dermatitis,,,,, -24699384,1265,,predisposes,,Clemastine,,,,allergic disease,,,,, -25081855,1266,,affects,,Tiapride,,,,Dopamine D2 Receptor,,,,, -19553406,1267,,causes,,Amisulpride,,,,schizophrenia,,,,, -9337142,1268,,causes,,Amisulpride,,,,psychotic disorder,,,,, -24415555,1269,,affects,,Amisulpride,,,,depressive disorder,,,,, -8493076,1270,,affects,,Amisulpride,,,,schizophrenia,,,,, -20532376,1271,,prevents,,Amisulpride,,,,Postoperative Nausea and Vomiting,,,,, -19821343,1272,,prevents,,Amisulpride,,,,Nausea,,,,, -11149280,1273,,physically interacts with,,Remoxipride,,,,Dopamine D2 Receptor,,,,, -9174370,1274,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, -24158881,1275,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, -20394421,1276,,affects,,Levosulpiride,,,,Dopamine D2 Receptor,,,,, -26880772,1277,,related to,,Nitroglycerin,,,,coronary artery disorder,,,,, -26139329,1278,,related to,,Nitroglycerin,,,,hypertensive disorder,,,,, -21173297,1279,,related to,,Nitroglycerin,,,,injury,,,,, -26585664,1280,,causes,,Nitroglycerin,,,,Raynaud disease,,,,, -26278376,1281,,causes,,Nitroglycerin,,,,Angina pectoris,,,,, -26148974,1282,,causes,,Nitroglycerin,,,,myocardial infarction,,,,, -15949436,1283,,causes,,Nitroglycerin,,,,injury,,,,, -15624022,1284,,causes,,Nitroglycerin,,,,Inflammation,,,,, -14985558,1285,,causes,,Nitroglycerin,,,,hypertensive disorder,,,,, -8402702,1286,,causes,,Nitroglycerin,,,,Pain,,,,, -7629693,1287,,causes,,Nitroglycerin,,,,hypotensive disorder,,,,, -26786108,1288,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, -26278652,1289,,affects,,Nitroglycerin,,,,hypotensive disorder,,,,, -25994904,1290,,affects,,Nitroglycerin,,,,Raynaud disease,,,,, -25747829,1291,,affects,,Nitroglycerin,,,,erectile dysfunction,,,,, -25260538,1292,,affects,,Nitroglycerin,,,,Muscle spasm,,,,, -23178151,1293,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, -20885558,1294,,affects,,Nitroglycerin,,,,injury,,,,, -18491008,1295,,affects,,Nitroglycerin,,,,Hot flashes,,,,, -14421188,1296,,affects,,Nitroglycerin,,,,Angina pectoris,,,,, -13478654,1297,,affects,,Nitroglycerin,,,,osteoporosis,,,,, -11707783,1298,,affects,,Nitroglycerin,,,,Pain,,,,, -11174035,1299,,affects,,Nitroglycerin,,,,hypertensive disorder,,,,, -10595566,1300,,affects,,Nitroglycerin,,,,stroke disorder,,,,, -8601510,1301,,affects,,Nitroglycerin,,,,myocardial ischemia,,,,, -8521770,1302,,affects,,Nitroglycerin,,,,phlebitis,,,,, -8049127,1303,,affects,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, -26813951,1304,,disrupts,,Nitroglycerin,,,,myocardial ischemia,,,,, -26590847,1305,,disrupts,,Nitroglycerin,,,,hypertensive disorder,,,,, -24386334,1306,,disrupts,,Nitroglycerin,,,,phlebitis,,,,, -19274234,1307,,disrupts,,Nitroglycerin,,,,injury,,,,, -10081147,1308,,disrupts,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, -9796564,1309,,disrupts,,Nitroglycerin,,,,Pain,,,,, -25569906,1310,,prevents,,Nitroglycerin,,,,phlebitis,,,,, -21983895,1311,,prevents,,Nitroglycerin,,,,Muscle spasm,,,,, -20473117,1312,,prevents,,Nitroglycerin,,,,Inflammation,,,,, -18491009,1313,,prevents,,Nitroglycerin,,,,Hot flashes,,,,, -17804368,1314,,prevents,,Nitroglycerin,,,,hypertensive disorder,,,,, -11496690,1315,,prevents,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, -10695579,1316,,prevents,,Nitroglycerin,,,,Angina pectoris,,,,, -10573276,1317,,prevents,,Nitroglycerin,,,,myocardial infarction,,,,, -9096899,1318,,prevents,,Nitroglycerin,,,,Pain,,,,, -9057729,1319,,prevents,,Nitroglycerin,,,,Shock,,,,, -8235862,1320,,prevents,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, -7713034,1321,,prevents,,Nitroglycerin,,,,injury,,,,, -13750741,1322,,exacerbates,,Nitroglycerin,,,,myocardial ischemia,,,,, -20483551,1323,,predisposes,,Nitroglycerin,,,,myocardial ischemia,,,,, -9897513,1324,,predisposes,,Nitroglycerin,,,,Angina pectoris,,,,, -20924645,1325,,related to,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, -10616906,1326,,related to,,Isosorbide dinitrate,,,,Angina pectoris,,,,, -9112334,1327,,related to,,Isosorbide dinitrate,,,,coronary artery disorder,,,,, -26334868,1328,,affects,,Isosorbide dinitrate,,,,Angina pectoris,,,,, -10884689,1329,,affects,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, -9112335,1330,,prevents,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, -17782283,1331,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, -7084056,1332,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, -25690684,1333,,causes,,Sulpiride,,,,depressive disorder,,,,, -26343015,1334,,affects,,Sulpiride,,,,schizophrenia,,,,, -23882267,1335,,affects,,Sulpiride,,,,anxiety,,,,, -8960439,1336,,affects,,Sulpiride,,,,depressive disorder,,,,, -8364166,1337,,affects,,Sulpiride,,,,Dopamine D2 Receptor,,,,, -7538297,1338,,affects,,Sulpiride,,,,depressive disorder,,,,, -25756981,1339,,disrupts,,Sulpiride,,,,depressive disorder,,,,, -8859505,1340,,disrupts,,Sulpiride,,,,anxiety,,,,, -26753868,1341,,causes,,Isosorbide mononitrate,,,,Angina pectoris,,,,, -15856723,1342,,affects,,Isosorbide mononitrate,,,,Angina pectoris,,,,, -24979081,1343,,prevents,,Isosorbide mononitrate,,,,vascular disorder,,,,, -22319748,1344,,prevents,,Isosorbide mononitrate,,,,Angina pectoris,,,,, -23203614,1345,,related to,,Ribociclib,,,,squamous cell carcinoma,,,,, -23890460,1346,,related to,,Abemaciclib,,,,non-small cell lung carcinoma,,,,, -24133672,1347,,affects,,Abemaciclib,,,,neoplasm,,,,, -23820208,1348,,disrupts,,Abemaciclib,,,,neoplasm,,,,, -7114439,1349,,subclass of,,Sodium Chloride,,,,Electrolytes,,,,, -27178225,1350,,related to,,Sodium Chloride,,,,hypoglycemia,,,,, -26906663,1351,,related to,,Sodium Chloride,,,,ventricular septal defect,,,,, -26538206,1352,,related to,,Sodium Chloride,,,,papilloma,,,,, -26529472,1353,,related to,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, -26267091,1354,,related to,,Sodium Chloride,,,,Sepsis,,,,, -26209731,1355,,related to,,Sodium Chloride,,,,cataract,,,,, -25917183,1356,,related to,,Sodium Chloride,,,,Hypoxemia,,,,, -20673450,1357,,related to,,Sodium Chloride,,,,Alzheimer disease,,,,, -20617514,1358,,related to,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, -20321366,1359,,related to,,Sodium Chloride,,,,type 1 diabetes mellitus,,,,, -19962817,1360,,related to,,Sodium Chloride,,,,Inflammation,,,,, -19891172,1361,,related to,,Sodium Chloride,,,,acute lung injury,,,,, -19636264,1362,,related to,,Sodium Chloride,,,,ischemic disease,,,,, -19577743,1363,,related to,,Sodium Chloride,,,,spinal cord injury,,,,, -19497082,1364,,related to,,Sodium Chloride,,,,primary ciliary dyskinesia,,,,, -18975700,1365,,related to,,Sodium Chloride,,,,bacterial infectious disease,,,,, -18966398,1366,,related to,,Sodium Chloride,,,,osteoarthritis,,,,, -18860303,1367,,related to,,Sodium Chloride,,,,bone fracture,,,,, -18738706,1368,,related to,,Sodium Chloride,,,,toxic shock syndrome,,,,, -18679247,1369,,related to,,Sodium Chloride,,,,Electrolytes,,,,, -18617363,1370,,related to,,Sodium Chloride,,,,iron deficiency anemia,,,,, -18287282,1371,,related to,,Sodium Chloride,,,,Pruritus,,,,, -17603340,1372,,related to,,Sodium Chloride,,,,brain injury,,,,, -17533385,1373,,related to,,Sodium Chloride,,,,myocardial infarction,,,,, -17525035,1374,,related to,,Sodium Chloride,,,,coronary artery disorder,,,,, -17213013,1375,,related to,,Sodium Chloride,,,,hepatocellular carcinoma,,,,, -17202845,1376,,related to,,Sodium Chloride,,,,Parkinson disease,,,,, -16886803,1377,,related to,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -16594665,1378,,related to,,Sodium Chloride,,,,Pain,,,,, -16433967,1379,,related to,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, -15412515,1380,,related to,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, -14710472,1381,,related to,,Sodium Chloride,,,,bronchiolitis,,,,, -14037713,1382,,related to,,Sodium Chloride,,,,ventricular tachycardia,,,,, -13928740,1383,,related to,,Sodium Chloride,,,,pulmonary edema,,,,, -13375642,1384,,related to,,Sodium Chloride,,,,Insulin resistance,,,,, -13343201,1385,,related to,,Sodium Chloride,,,,Hypernatremia,,,,, -13277977,1386,,related to,,Sodium Chloride,,,,diabetic ketoacidosis,,,,, -11905993,1387,,related to,,Sodium Chloride,,,,depressive disorder,,,,, -11014479,1388,,related to,,Sodium Chloride,,,,glaucoma,,,,, -10966302,1389,,related to,,Sodium Chloride,,,,malaria,,,,, -10739226,1390,,related to,,Sodium Chloride,,,,heart disorder,,,,, -10689901,1391,,related to,,Sodium Chloride,,,,diabetes mellitus,,,,, -10566407,1392,,related to,,Sodium Chloride,,,,brain cancer,,,,, -10531148,1393,,related to,,Sodium Chloride,,,,kidney failure,,,,, -10510273,1394,,related to,,Sodium Chloride,,,,Shock,,,,, -10504585,1395,,related to,,Sodium Chloride,,,,tuberculosis,,,,, -10502982,1396,,related to,,Sodium Chloride,,,,nutritional disorder,,,,, -10502981,1397,,related to,,Sodium Chloride,,,,cirrhosis of liver,,,,, -10487095,1398,,related to,,Sodium Chloride,,,,pneumonia,,,,, -10439781,1399,,related to,,Sodium Chloride,,,,acute kidney failure,,,,, -10433628,1400,,related to,,Sodium Chloride,,,,psoriasis,,,,, -10370762,1401,,related to,,Sodium Chloride,,,,Hypothermia,,,,, -10318383,1402,,related to,,Sodium Chloride,,,,cardiovascular disorder,,,,, -10300324,1403,,related to,,Sodium Chloride,,,,stroke disorder,,,,, -10268953,1404,,related to,,Sodium Chloride,,,,brain edema,,,,, -9985623,1405,,related to,,Sodium Chloride,,,,Nausea,,,,, -9642141,1406,,related to,,Sodium Chloride,,,,obesity disorder,,,,, -9504754,1407,,related to,,Sodium Chloride,,,,asthma,,,,, -9350794,1408,,related to,,Sodium Chloride,,,,essential hypertension,,,,, -9217528,1409,,related to,,Sodium Chloride,,,,dry eye syndrome,,,,, -8489872,1410,,related to,,Sodium Chloride,,,,injury,,,,, -8486278,1411,,related to,,Sodium Chloride,,,,cystic fibrosis,,,,, -7822303,1412,,related to,,Sodium Chloride,,,,neoplasm,,,,, -7455347,1413,,related to,,Sodium Chloride,,,,Hypovolemia,,,,, -7397406,1414,,related to,,Sodium Chloride,,,,kidney disorder,,,,, -7259411,1415,,related to,,Sodium Chloride,,,,hypertensive disorder,,,,, -19769676,1416,,related to,,Sodium Chloride,,,,Electrolytes,,,,, -18679248,1417,,close match,,Sodium Chloride,,,,Electrolytes,,,,, -7792933,1418,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, -9181325,1419,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, -27223278,1420,,derives from,,Sodium Chloride,,,,Electrolytes,,,,, -9585905,1421,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, -9585904,1422,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, -26947391,1423,,causes,,Sodium Chloride,,,,acute kidney tubular necrosis,,,,, -26813055,1424,,causes,,Sodium Chloride,,,,Dyspnea,,,,, -26651944,1425,,causes,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, -26200221,1426,,causes,,Sodium Chloride,,,,melanoma,,,,, -25963723,1427,,causes,,Sodium Chloride,,,,cardiac arrest,,,,, -24999522,1428,,causes,,Sodium Chloride,,,,Nausea,,,,, -23507574,1429,,causes,,Sodium Chloride,,,,burn,,,,, -21365055,1430,,causes,,Sodium Chloride,,,,respiratory failure,,,,, -20716492,1431,,causes,,Sodium Chloride,,,,multiple organ dysfunction syndrome,,,,, -20666627,1432,,causes,,Sodium Chloride,,,,malaria,,,,, -20168868,1433,,causes,,Sodium Chloride,,,,fibromyalgia,,,,, -19652731,1434,,causes,,Sodium Chloride,,,,Chronic pain,,,,, -19581650,1435,,causes,,Sodium Chloride,,,,neoplasm,,,,, -19527177,1436,,causes,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, -19434783,1437,,causes,,Sodium Chloride,,,,Low back pain,,,,, -19352698,1438,,causes,,Sodium Chloride,,,,bone fracture,,,,, -19268574,1439,,causes,,Sodium Chloride,,,,ulcerative colitis,,,,, -18873789,1440,,causes,,Sodium Chloride,,,,preeclampsia,,,,, -18760766,1441,,causes,,Sodium Chloride,,,,heart disorder,,,,, -18419412,1442,,causes,,Sodium Chloride,,,,infertility disorder,,,,, -18184755,1443,,causes,,Sodium Chloride,,,,intervertebral disc degenerative disorder,,,,, -18174270,1444,,causes,,Sodium Chloride,,,,asthma,,,,, -17957169,1445,,causes,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, -17846702,1446,,causes,,Sodium Chloride,,,,cardiovascular disorder,,,,, -17472790,1447,,causes,,Sodium Chloride,,,,Postoperative Complications,,,,, -17050802,1448,,causes,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, -16922792,1449,,causes,,Sodium Chloride,,,,aortic aneurysm,,,,, -16902385,1450,,causes,,Sodium Chloride,,,,Hypoxemia,,,,, -16884655,1451,,causes,,Sodium Chloride,,,,obesity disorder,,,,, -15862216,1452,,causes,,Sodium Chloride,,,,Sepsis,,,,, -15183436,1453,,causes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -14507617,1454,,causes,,Sodium Chloride,,,,brain edema,,,,, -14335740,1455,,causes,,Sodium Chloride,,,,essential hypertension,,,,, -14100671,1456,,causes,,Sodium Chloride,,,,Cough,,,,, -13899816,1457,,causes,,Sodium Chloride,,,,brain injury,,,,, -13415978,1458,,causes,,Sodium Chloride,,,,rhinitis,,,,, -13156241,1459,,causes,,Sodium Chloride,,,,allergic disease,,,,, -12922926,1460,,causes,,Sodium Chloride,,,,periodontitis,,,,, -12796728,1461,,causes,,Sodium Chloride,,,,myocardial infarction,,,,, -12757253,1462,,causes,,Sodium Chloride,,,,urticaria,,,,, -12052924,1463,,causes,,Sodium Chloride,,,,Fever,,,,, -11367442,1464,,causes,,Sodium Chloride,,,,Hypothermia,,,,, -10844905,1465,,causes,,Sodium Chloride,,,,kidney disorder,,,,, -10703852,1466,,causes,,Sodium Chloride,,,,Ascites,,,,, -10680402,1467,,causes,,Sodium Chloride,,,,kidney failure,,,,, -10468869,1468,,causes,,Sodium Chloride,,,,Hyperhidrosis,,,,, -10303736,1469,,causes,,Sodium Chloride,,,,Hemorrhage,,,,, -10216492,1470,,causes,,Sodium Chloride,,,,Insulin resistance,,,,, -9649854,1471,,causes,,Sodium Chloride,,,,Inflammation,,,,, -9417058,1472,,causes,,Sodium Chloride,,,,stroke disorder,,,,, -9370401,1473,,causes,,Sodium Chloride,,,,acute kidney failure,,,,, -9311776,1474,,causes,,Sodium Chloride,,,,hypotensive disorder,,,,, -8912328,1475,,causes,,Sodium Chloride,,,,injury,,,,, -8760965,1476,,causes,,Sodium Chloride,,,,hyperinsulinism,,,,, -8723767,1477,,causes,,Sodium Chloride,,,,Hyponatremia,,,,, -8658207,1478,,causes,,Sodium Chloride,,,,ischemic disease,,,,, -8215909,1479,,causes,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, -7966995,1480,,causes,,Sodium Chloride,,,,Shock,,,,, -7871886,1481,,causes,,Sodium Chloride,,,,Hypernatremia,,,,, -7769838,1482,,causes,,Sodium Chloride,,,,Pain,,,,, -7535626,1483,,causes,,Sodium Chloride,,,,pulmonary edema,,,,, -7170398,1484,,causes,,Sodium Chloride,,,,cataract,,,,, -7067270,1485,,causes,,Sodium Chloride,,,,hypertensive disorder,,,,, -27640062,1486,,affects,,Sodium Chloride,,,,hyperinsulinism,,,,, -27459630,1487,,affects,,Sodium Chloride,,,,ischemic disease,,,,, -26883243,1488,,affects,,Sodium Chloride,,,,pulmonary edema,,,,, -25873721,1489,,affects,,Sodium Chloride,,,,stroke disorder,,,,, -25698961,1490,,affects,,Sodium Chloride,,,,Hypovolemia,,,,, -23350231,1491,,affects,,Sodium Chloride,,,,allergic disease,,,,, -21279163,1492,,affects,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, -19916489,1493,,affects,,Sodium Chloride,,,,malaria,,,,, -19654566,1494,,affects,,Sodium Chloride,,,,Fever,,,,, -19387644,1495,,affects,,Sodium Chloride,,,,Dyspnea,,,,, -19198162,1496,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, -19068195,1497,,affects,,Sodium Chloride,,,,Pain,,,,, -18857149,1498,,affects,,Sodium Chloride,,,,injury,,,,, -18063112,1499,,affects,,Sodium Chloride,,,,myocardial infarction,,,,, -17981225,1500,,affects,,Sodium Chloride,,,,Fever,,,,, -17956116,1501,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, -17749046,1502,,affects,,Sodium Chloride,,,,asthma,,,,, -17453252,1503,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, -17320603,1504,,affects,,Sodium Chloride,,,,brain injury,,,,, -17252322,1505,,affects,,Sodium Chloride,,,,iron deficiency anemia,,,,, -17081119,1506,,affects,,Sodium Chloride,,,,cataract,,,,, -17021361,1507,,affects,,Sodium Chloride,,,,urticaria,,,,, -16829226,1508,,affects,,Sodium Chloride,,,,osteoarthritis,,,,, -16392979,1509,,affects,,Sodium Chloride,,,,Sepsis,,,,, -16339812,1510,,affects,,Sodium Chloride,,,,Inflammation,,,,, -16191401,1511,,affects,,Sodium Chloride,,,,Shock,,,,, -16150899,1512,,affects,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, -15784044,1513,,affects,,Sodium Chloride,,,,Electrolytes,,,,, -15684126,1514,,affects,,Sodium Chloride,,,,malaria,,,,, -15518572,1515,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -15358630,1516,,affects,,Sodium Chloride,,,,brain injury,,,,, -14974493,1517,,affects,,Sodium Chloride,,,,cardiovascular disorder,,,,, -14875621,1518,,affects,,Sodium Chloride,,,,Hypoxemia,,,,, -14652078,1519,,affects,,Sodium Chloride,,,,preeclampsia,,,,, -14650670,1520,,affects,,Sodium Chloride,,,,Ascites,,,,, -14454543,1521,,affects,,Sodium Chloride,,,,Inflammation,,,,, -14269847,1522,,affects,,Sodium Chloride,,,,kidney disorder,,,,, -13713189,1523,,affects,,Sodium Chloride,,,,acute lung injury,,,,, -13361928,1524,,affects,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -13091031,1525,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -12113298,1526,,affects,,Sodium Chloride,,,,diabetes mellitus,,,,, -11936868,1527,,affects,,Sodium Chloride,,,,allergic disease,,,,, -11761266,1528,,affects,,Sodium Chloride,,,,stroke disorder,,,,, -11373059,1529,,affects,,Sodium Chloride,,,,Pain,,,,, -11352407,1530,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, -10762234,1531,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, -10689150,1532,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, -10555492,1533,,affects,,Sodium Chloride,,,,nutritional disorder,,,,, -10543207,1534,,affects,,Sodium Chloride,,,,myocarditis,,,,, -10409590,1535,,affects,,Sodium Chloride,,,,essential hypertension,,,,, -10373089,1536,,affects,,Sodium Chloride,,,,Hypernatremia,,,,, -10347664,1537,,affects,,Sodium Chloride,,,,neoplasm,,,,, -10303742,1538,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, -10216887,1539,,affects,,Sodium Chloride,,,,Shock,,,,, -10038950,1540,,affects,,Sodium Chloride,,,,injury,,,,, -9833746,1541,,affects,,Sodium Chloride,,,,obesity disorder,,,,, -9701968,1542,,affects,,Sodium Chloride,,,,brain edema,,,,, -9235049,1543,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, -9211629,1544,,affects,,Sodium Chloride,,,,asthma,,,,, -8885675,1545,,affects,,Sodium Chloride,,,,Ascites,,,,, -8142503,1546,,affects,,Sodium Chloride,,,,Insulin resistance,,,,, -7538296,1547,,affects,,Sodium Chloride,,,,depressive disorder,,,,, -7487288,1548,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, -7249676,1549,,affects,,Sodium Chloride,,,,Fever,,,,, -7189372,1550,,affects,,Sodium Chloride,,,,depressive disorder,,,,, -7186849,1551,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, -7146026,1552,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, -10370500,1553,,affects,,Sodium Chloride,,,,Electrolytes,,,,, -14010559,1554,,produces,,Sodium Chloride,,,,hypertensive disorder,,,,, -25864505,1555,,disrupts,,Sodium Chloride,,,,malaria,,,,, -19817939,1556,,disrupts,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, -19569177,1557,,disrupts,,Sodium Chloride,,,,anxiety,,,,, -19347835,1558,,disrupts,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -19339201,1559,,disrupts,,Sodium Chloride,,,,Cough,,,,, -18711875,1560,,disrupts,,Sodium Chloride,,,,pulmonary edema,,,,, -18638520,1561,,disrupts,,Sodium Chloride,,,,brain edema,,,,, -18394970,1562,,disrupts,,Sodium Chloride,,,,Inflammation,,,,, -17319016,1563,,disrupts,,Sodium Chloride,,,,dental caries,,,,, -17223012,1564,,disrupts,,Sodium Chloride,,,,hypertensive disorder,,,,, -17223011,1565,,disrupts,,Sodium Chloride,,,,cardiovascular disorder,,,,, -17009512,1566,,disrupts,,Sodium Chloride,,,,allergic disease,,,,, -13585452,1567,,disrupts,,Sodium Chloride,,,,neoplasm,,,,, -12586414,1568,,disrupts,,Sodium Chloride,,,,Hypoxemia,,,,, -12214170,1569,,disrupts,,Sodium Chloride,,,,injury,,,,, -10927798,1570,,disrupts,,Sodium Chloride,,,,stroke disorder,,,,, -8273399,1571,,disrupts,,Sodium Chloride,,,,Pain,,,,, -27207716,1572,,prevents,,Sodium Chloride,,,,periodontal disorder,,,,, -27075073,1573,,prevents,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, -23771600,1574,,prevents,,Sodium Chloride,,,,sinusitis,,,,, -21279166,1575,,prevents,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, -20586429,1576,,prevents,,Sodium Chloride,,,,stroke disorder,,,,, -20472317,1577,,prevents,,Sodium Chloride,,,,myocardial infarction,,,,, -20150308,1578,,prevents,,Sodium Chloride,,,,Chronic pain,,,,, -20050861,1579,,prevents,,Sodium Chloride,,,,Dyspnea,,,,, -19622277,1580,,prevents,,Sodium Chloride,,,,Pruritus,,,,, -19347836,1581,,prevents,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -18643598,1582,,prevents,,Sodium Chloride,,,,ventricular tachycardia,,,,, -18145237,1583,,prevents,,Sodium Chloride,,,,Nausea,,,,, -17285701,1584,,prevents,,Sodium Chloride,,,,neuralgia,,,,, -17081118,1585,,prevents,,Sodium Chloride,,,,cataract,,,,, -16603496,1586,,prevents,,Sodium Chloride,,,,brain injury,,,,, -16427621,1587,,prevents,,Sodium Chloride,,,,diabetes mellitus,,,,, -16310359,1588,,prevents,,Sodium Chloride,,,,burn,,,,, -16010295,1589,,prevents,,Sodium Chloride,,,,ischemic disease,,,,, -15507954,1590,,prevents,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, -15307837,1591,,prevents,,Sodium Chloride,,,,acute lung injury,,,,, -15219283,1592,,prevents,,Sodium Chloride,,,,allergic disease,,,,, -14919203,1593,,prevents,,Sodium Chloride,,,,spinal cord injury,,,,, -14359710,1594,,prevents,,Sodium Chloride,,,,obesity disorder,,,,, -14313516,1595,,prevents,,Sodium Chloride,,,,Inflammation,,,,, -14313515,1596,,prevents,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, -13297854,1597,,prevents,,Sodium Chloride,,,,kidney disorder,,,,, -12464836,1598,,prevents,,Sodium Chloride,,,,malaria,,,,, -12453134,1599,,prevents,,Sodium Chloride,,,,iron deficiency anemia,,,,, -12276610,1600,,prevents,,Sodium Chloride,,,,essential hypertension,,,,, -12092501,1601,,prevents,,Sodium Chloride,,,,hypertensive disorder,,,,, -11205687,1602,,prevents,,Sodium Chloride,,,,acute kidney failure,,,,, -10429352,1603,,prevents,,Sodium Chloride,,,,injury,,,,, -10205494,1604,,prevents,,Sodium Chloride,,,,Hypovolemia,,,,, -9628485,1605,,prevents,,Sodium Chloride,,,,anemia,,,,, -8227059,1606,,prevents,,Sodium Chloride,,,,Shock,,,,, -8196581,1607,,prevents,,Sodium Chloride,,,,dental caries,,,,, -8059428,1608,,prevents,,Sodium Chloride,,,,Pain,,,,, -22103068,1609,,exacerbates,,Sodium Chloride,,,,hypertensive disorder,,,,, -20308305,1610,,exacerbates,,Sodium Chloride,,,,Inflammation,,,,, -21816011,1611,,predisposes,,Sodium Chloride,,,,essential hypertension,,,,, -19774957,1612,,predisposes,,Sodium Chloride,,,,pulmonary edema,,,,, -18380691,1613,,predisposes,,Sodium Chloride,,,,myocardial infarction,,,,, -18041213,1614,,predisposes,,Sodium Chloride,,,,Inflammation,,,,, -16033022,1615,,predisposes,,Sodium Chloride,,,,injury,,,,, -13840593,1616,,predisposes,,Sodium Chloride,,,,allergic disease,,,,, -13808663,1617,,predisposes,,Sodium Chloride,,,,diabetes mellitus,,,,, -13731023,1618,,predisposes,,Sodium Chloride,,,,cardiovascular disorder,,,,, -12280034,1619,,predisposes,,Sodium Chloride,,,,neoplasm,,,,, -12079247,1620,,predisposes,,Sodium Chloride,,,,hypertensive disorder,,,,, -11776631,1621,,predisposes,,Sodium Chloride,,,,stroke disorder,,,,, -11266800,1622,,predisposes,,Sodium Chloride,,,,kidney disorder,,,,, -10118531,1623,,predisposes,,Sodium Chloride,,,,obesity disorder,,,,, -9111875,1624,,predisposes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, -9647073,1625,,related to,,Dexpanthenol,,,,skin disorder,,,,, -26305399,1626,,affects,,Dexpanthenol,,,,Erythema,,,,, -25421467,1627,,prevents,,Dexpanthenol,,,,cheilitis,,,,, -24024712,1628,,related to,,ELTROMBOPAG,,,,autoimmune thrombocytopenic purpura,,,,, -22097814,1629,,related to,,ELTROMBOPAG,,,,acute myeloid leukemia,,,,, -22063304,1630,,related to,,ELTROMBOPAG,,,,aplastic anemia,,,,, -22063303,1631,,related to,,ELTROMBOPAG,,,,myelodysplastic syndrome,,,,, -22049758,1632,,related to,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -23835836,1633,,causes,,ELTROMBOPAG,,,,anemia,,,,, -22601227,1634,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -21709185,1635,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -22821304,1636,,prevents,,ELTROMBOPAG,,,,Hemorrhage,,,,, -22169266,1637,,prevents,,ELTROMBOPAG,,,,thrombocytopenia,,,,, -12546229,1638,,affects,,Etamsylate,,,,Hemorrhage,,,,, -9791897,1639,,affects,,Etamsylate,,,,Hemorrhage,,,,, -22608563,1640,,prevents,,Etamsylate,,,,Hemorrhage,,,,, -26536250,1641,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -26536250,1642,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -26158944,1643,,related to,,mitomycin C,,,,adenocarcinoma,,,,, -26111339,1644,,related to,,mitomycin C,,,,squamous cell carcinoma,,,,, -26043076,1645,,related to,,mitomycin C,,,,neoplasm,,,,, -25722815,1646,,related to,,mitomycin C,,,,leukemia,,,,, -12722759,1647,,related to,,mitomycin C,,,,carcinoma,,,,, -10467532,1648,,related to,,mitomycin C,,,,non-small cell lung carcinoma,,,,, -7255625,1649,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -7255625,1650,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8689799,1651,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8689799,1652,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8030161,1653,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8030161,1654,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -7255626,1655,,physically interacts with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -25769130,1656,,causes,,mitomycin C,,,,sarcoma,,,,, -25692678,1657,,causes,,mitomycin C,,,,hepatocellular carcinoma,,,,, -20975852,1658,,causes,,mitomycin C,,,,carcinoma,,,,, -12184177,1659,,causes,,mitomycin C,,,,Corneal opacity,,,,, -11626710,1660,,causes,,mitomycin C,,,,urethral stricture,,,,, -9485346,1661,,causes,,mitomycin C,,,,neoplasm,,,,, -26017044,1662,,affects,,mitomycin C,,,,squamous cell carcinoma,,,,, -25924198,1663,,affects,,mitomycin C,,,,adenocarcinoma,,,,, -24961205,1664,,affects,,mitomycin C,,,,neoplasm,,,,, -21183193,1665,,affects,,mitomycin C,,,,transitional cell carcinoma,,,,, -20995393,1666,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, -20865956,1667,,affects,,mitomycin C,,,,pterygium,,,,, -17166086,1668,,affects,,mitomycin C,,,,mesothelioma,,,,, -15342296,1669,,affects,,mitomycin C,,,,sclerosing cholangitis,,,,, -14897135,1670,,affects,,mitomycin C,,,,Corneal opacity,,,,, -14480408,1671,,affects,,mitomycin C,,,,liver and intrahepatic bile duct neoplasm,,,,, -14435862,1672,,affects,,mitomycin C,,,,Corneal opacity,,,,, -10146530,1673,,affects,,mitomycin C,,,,open-angle glaucoma,,,,, -8885108,1674,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, -8612675,1675,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -8242643,1676,,affects,,mitomycin C,,,,neoplasm,,,,, -8428809,1677,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, -26926271,1678,,disrupts,,mitomycin C,,,,Neoplasm Metastasis,,,,, -21172443,1679,,disrupts,,mitomycin C,,,,urinary bladder neoplasm,,,,, -16608751,1680,,disrupts,,mitomycin C,,,,carcinoma,,,,, -12093037,1681,,disrupts,,mitomycin C,,,,neoplasm,,,,, -8920186,1682,,disrupts,,mitomycin C,,,,Corneal opacity,,,,, -22973529,1683,,prevents,,mitomycin C,,,,glaucoma,,,,, -19902018,1684,,prevents,,mitomycin C,,,,keratoconus,,,,, -19673685,1685,,prevents,,mitomycin C,,,,urethral stricture,,,,, -12959208,1686,,prevents,,mitomycin C,,,,Neoplasm Metastasis,,,,, -11642092,1687,,prevents,,mitomycin C,,,,Esophageal stenosis,,,,, -9925117,1688,,prevents,,mitomycin C,,,,neoplasm,,,,, -8410588,1689,,prevents,,mitomycin C,,,,pterygium,,,,, -7308263,1690,,prevents,,mitomycin C,,,,urinary bladder neoplasm,,,,, -20886584,1691,,predisposes,,mitomycin C,,,,neoplasm,,,,, -17638153,1692,,related to,,Cefazolin,,,,bone fracture,,,,, -20958121,1693,,causes,,Cefazolin,,,,bacterial infectious disease with sepsis,,,,, -25339548,1694,,affects,,Cefazolin,,,,obesity disorder,,,,, -27670629,1695,,prevents,,Cefazolin,,,,staphylococcal infection,,,,, -10537097,1696,,prevents,,Cefazolin,,,,bacterial infectious disease,,,,, -7415834,1697,,affects,,Famciclovir,,,,herpes zoster,,,,, -27310156,1698,,disrupts,,Famciclovir,,,,viral infectious disease,,,,, -11859744,1699,,disrupts,,Famciclovir,,,,herpes simplex infectious disease,,,,, -11859743,1700,,disrupts,,Famciclovir,,,,genital herpes,,,,, -7415831,1701,,prevents,,Famciclovir,,,,herpes zoster,,,,, -27248580,1702,,related to,,Acyclovir,,,,herpes zoster,,,,, -20916830,1703,,causes,,Acyclovir,,,,viral infectious disease,,,,, -21459205,1704,,affects,,Acyclovir,,,,herpes zoster,,,,, -17108497,1705,,affects,,Acyclovir,,,,genital herpes,,,,, -15677184,1706,,affects,,Acyclovir,,,,viral infectious disease,,,,, -9966648,1707,,affects,,Acyclovir,,,,chickenpox,,,,, -8137898,1708,,affects,,Acyclovir,,,,cytomegalovirus infection,,,,, -26100053,1709,,disrupts,,Acyclovir,,,,herpes zoster,,,,, -21196251,1710,,disrupts,,Acyclovir,,,,cytomegalovirus infection,,,,, -21045605,1711,,disrupts,,Acyclovir,,,,herpes simplex infectious disease,,,,, -13979845,1712,,disrupts,,Acyclovir,,,,HIV infectious disease,,,,, -11163493,1713,,disrupts,,Acyclovir,,,,chickenpox,,,,, -10081763,1714,,disrupts,,Acyclovir,,,,viral infectious disease,,,,, -8112053,1715,,disrupts,,Acyclovir,,,,genital herpes,,,,, -22220716,1716,,prevents,,Acyclovir,,,,chickenpox,,,,, -14453930,1717,,prevents,,Acyclovir,,,,herpes zoster,,,,, -11048138,1718,,prevents,,Acyclovir,,,,herpes labialis,,,,, -10652424,1719,,prevents,,Acyclovir,,,,viral infectious disease,,,,, -9977810,1720,,prevents,,Acyclovir,,,,genital herpes,,,,, -8973083,1721,,prevents,,Acyclovir,,,,cytomegalovirus infection,,,,, -8455850,1722,,prevents,,Acyclovir,,,,herpes simplex infectious disease,,,,, -16777411,1723,,predisposes,,Acyclovir,,,,herpes simplex infectious disease,,,,, -14602481,1724,,predisposes,,Acyclovir,,,,HIV infectious disease,,,,, -7066348,1725,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -7066348,1726,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -10786366,1727,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -10786366,1728,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -15969143,1729,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -15969143,1730,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -10765452,1731,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -8193345,1732,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -13332148,1733,,causes,,Idoxuridine,,,,viral infectious disease,,,,, -25762983,1734,,affects,,Idoxuridine,,,,viral infectious disease,,,,, -25024576,1735,,affects,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, -25798138,1736,,affects,,Vidarabine,,,,herpes simplex infectious disease,,,,, -18005400,1737,,related to,,Ganciclovir,,,,AIDS,,,,, -11769089,1738,,related to,,Ganciclovir,,,,lymphoma,,,,, -7813894,1739,,causes,,Ganciclovir,,,,hepatocellular carcinoma,,,,, -21315977,1740,,affects,,Ganciclovir,,,,melanoma,,,,, -18696617,1741,,affects,,Ganciclovir,,,,viral infectious disease,,,,, -14018850,1742,,affects,,Ganciclovir,,,,graft versus host disease,,,,, -7745805,1743,,affects,,Ganciclovir,,,,hepatocellular carcinoma,,,,, -7264703,1744,,affects,,Ganciclovir,,,,retinitis,,,,, -7193112,1745,,affects,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, -27515973,1746,,disrupts,,Ganciclovir,,,,viral infectious disease,,,,, -20042666,1747,,disrupts,,Ganciclovir,,,,glioblastoma,,,,, -11829393,1748,,disrupts,,Ganciclovir,,,,cytomegalovirus infection,,,,, -9242712,1749,,disrupts,,Ganciclovir,,,,hepatocellular carcinoma,,,,, -27273103,1750,,prevents,,Ganciclovir,,,,retinitis,,,,, -14947813,1751,,prevents,,Ganciclovir,,,,viral infectious disease,,,,, -8898867,1752,,prevents,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, -7606615,1753,,prevents,,Ganciclovir,,,,cytomegalovirus infection,,,,, -26756507,1754,,affects,,Nedocromil,,,,asthma,,,,, -12807968,1755,,affects,,Nedocromil,,,,asthma,,,,, -15773495,1756,,disrupts,,Nedocromil,,,,asthma,,,,, -26602335,1757,,prevents,,Nedocromil,,,,asthma,,,,, -25857910,1758,,related to,,Flumedroxone,,,,migraine disorder,,,,, -26456255,1759,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, -26456255,1760,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, -26331358,1761,,affects,,Valrubicin,,,,Deoxyribonucleic acid,,,,, -9013591,1762,,affects,,Valrubicin,,,,neoplasm,,,,, -15048973,1763,,disrupts,,Valrubicin,,,,neoplasm,,,,, -19780799,1764,,related to,,Idarubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -19123529,1765,,related to,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, -17160344,1766,,related to,,Idarubicin,,,,myelodysplastic syndrome,,,,, -13481436,1767,,related to,,Idarubicin,,,,acute myeloid leukemia,,,,, -12261572,1768,,related to,,Idarubicin,,,,plasma cell myeloma,,,,, -10347974,1769,,related to,,Idarubicin,,,,non-Hodgkin lymphoma,,,,, -8798925,1770,,related to,,Idarubicin,,,,acute promyelocytic leukemia,,,,, -17955637,1771,,causes,,Idarubicin,,,,acute myeloid leukemia,,,,, -10037923,1772,,causes,,Idarubicin,,,,neutropenia,,,,, -27637811,1773,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, -27582612,1774,,affects,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, -27363552,1775,,affects,,Idarubicin,,,,neoplasm,,,,, -10133635,1776,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, -9755321,1777,,affects,,Idarubicin,,,,leukemia,,,,, -9560678,1778,,affects,,Idarubicin,,,,neoplasm,,,,, -9242996,1779,,affects,,Idarubicin,,,,neutropenia,,,,, -18342294,1780,,causes,,Pirarubicin,,,,neoplasm,,,,, -16182034,1781,,affects,,Pirarubicin,,,,neoplasm,,,,, -19153993,1782,,disrupts,,Pirarubicin,,,,neoplasm,,,,, -14778803,1783,,prevents,,Pirarubicin,,,,neoplasm,,,,, -20218174,1784,,subclass of,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, -25737166,1785,,related to,,Mitoxantrone,,,,lymphoma,,,,, -19961419,1786,,related to,,Mitoxantrone,,,,breast neoplasm,,,,, -14217137,1787,,related to,,Mitoxantrone,,,,mantle cell lymphoma,,,,, -13051364,1788,,related to,,Mitoxantrone,,,,multiple sclerosis,,,,, -8903075,1789,,related to,,Mitoxantrone,,,,acute myeloid leukemia,,,,, -8584278,1790,,causes,,Mitoxantrone,,,,acute myeloid leukemia,,,,, -26143277,1791,,affects,,Mitoxantrone,,,,lymphoma,,,,, -20218175,1792,,affects,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, -11986455,1793,,affects,,Mitoxantrone,,,,multiple sclerosis,,,,, -9134230,1794,,prevents,,Mitoxantrone,,,,neoplasm,,,,, -11307631,1795,,exacerbates,,Mitoxantrone,,,,multiple sclerosis,,,,, -26844498,1796,,related to,,Doxorubicin,,,,renal cell carcinoma,,,,, -26506763,1797,,related to,,Doxorubicin,,,,Kaposi's sarcoma,,,,, -26097255,1798,,related to,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -25468576,1799,,related to,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, -21586070,1800,,related to,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, -17293414,1801,,related to,,Doxorubicin,,,,neoplasm,,,,, -14824461,1802,,related to,,Doxorubicin,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -12975330,1803,,related to,,Doxorubicin,,,,"Lymphoma, AIDS-Related",,,,, -12635005,1804,,related to,,Doxorubicin,,,,neuroendocrine neoplasm,,,,, -11664648,1805,,related to,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, -8248824,1806,,related to,,Doxorubicin,,,,lymphoma,,,,, -7897058,1807,,related to,,Doxorubicin,,,,leukemia,,,,, -7111309,1808,,related to,,Doxorubicin,,,,Hodgkins lymphoma,,,,, -26198671,1809,,causes,,Doxorubicin,,,,acute myeloid leukemia,,,,, -20905498,1810,,causes,,Doxorubicin,,,,prostate cancer,,,,, -19998968,1811,,causes,,Doxorubicin,,,,Hodgkins lymphoma,,,,, -17176693,1812,,causes,,Doxorubicin,,,,B-cell neoplasm,,,,, -16306119,1813,,causes,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -14936910,1814,,causes,,Doxorubicin,,,,plasma cell myeloma,,,,, -13613509,1815,,causes,,Doxorubicin,,,,sarcoma,,,,, -12176485,1816,,causes,,Doxorubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -12086573,1817,,causes,,Doxorubicin,,,,leukemia,,,,, -11480674,1818,,causes,,Doxorubicin,,,,Neoplasm Metastasis,,,,, -11088747,1819,,causes,,Doxorubicin,,,,neoplasm,,,,, -7374660,1820,,causes,,Doxorubicin,,,,neutropenia,,,,, -25410483,1821,,affects,,Doxorubicin,,,,glioma,,,,, -25202161,1822,,affects,,Doxorubicin,,,,glioblastoma,,,,, -24066270,1823,,affects,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, -23980169,1824,,affects,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, -20976248,1825,,affects,,Doxorubicin,,,,neuroblastoma,,,,, -20526631,1826,,affects,,Doxorubicin,,,,gastric neoplasm,,,,, -20464122,1827,,affects,,Doxorubicin,,,,T-cell non-Hodgkin lymphoma,,,,, -19907850,1828,,affects,,Doxorubicin,,,,renal cell carcinoma,,,,, -18966824,1829,,affects,,Doxorubicin,,,,leiomyosarcoma,,,,, -18841320,1830,,affects,,Doxorubicin,,,,B-cell chronic lymphocytic leukemia,,,,, -17410518,1831,,affects,,Doxorubicin,,,,rhabdomyosarcoma,,,,, -17166104,1832,,affects,,Doxorubicin,,,,mesothelioma,,,,, -17156749,1833,,affects,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, -17092174,1834,,affects,,Doxorubicin,,,,glioma,,,,, -16319458,1835,,affects,,Doxorubicin,,,,sarcoma,,,,, -15641121,1836,,affects,,Doxorubicin,,,,liver and intrahepatic bile duct neoplasm,,,,, -15592048,1837,,affects,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, -15335028,1838,,affects,,Doxorubicin,,,,pancreatic ductal adenocarcinoma,,,,, -15288278,1839,,affects,,Doxorubicin,,,,mantle cell lymphoma,,,,, -15233880,1840,,affects,,Doxorubicin,,,,prostate cancer,,,,, -14862593,1841,,affects,,Doxorubicin,,,,liposarcoma,,,,, -13717435,1842,,affects,,Doxorubicin,,,,prostate cancer,,,,, -13641465,1843,,affects,,Doxorubicin,,,,Ewing sarcoma,,,,, -13641464,1844,,affects,,Doxorubicin,,,,bone osteosarcoma,,,,, -13477582,1845,,affects,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -12593977,1846,,affects,,Doxorubicin,,,,Kaposi's sarcoma,,,,, -12038917,1847,,affects,,Doxorubicin,,,,acute lymphoblastic leukemia,,,,, -11963770,1848,,affects,,Doxorubicin,,,,angiosarcoma,,,,, -11068243,1849,,affects,,Doxorubicin,,,,neutropenia,,,,, -9029101,1850,,affects,,Doxorubicin,,,,neoplasm,,,,, -7957058,1851,,affects,,Doxorubicin,,,,neoplasm,,,,, -7468708,1852,,affects,,Doxorubicin,,,,carcinoma,,,,, -7221748,1853,,affects,,Doxorubicin,,,,small cell lung carcinoma,,,,, -22415368,1854,,disrupts,,Doxorubicin,,,,glioma,,,,, -21775806,1855,,disrupts,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, -19908932,1856,,disrupts,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, -19216444,1857,,disrupts,,Doxorubicin,,,,lymphoma,,,,, -18593046,1858,,disrupts,,Doxorubicin,,,,bone osteosarcoma,,,,, -17338969,1859,,disrupts,,Doxorubicin,,,,melanoma,,,,, -15233882,1860,,disrupts,,Doxorubicin,,,,prostate cancer,,,,, -15026936,1861,,disrupts,,Doxorubicin,,,,B-cell neoplasm,,,,, -14123664,1862,,disrupts,,Doxorubicin,,,,hepatocellular carcinoma,,,,, -11529496,1863,,disrupts,,Doxorubicin,,,,neuroblastoma,,,,, -8800155,1864,,disrupts,,Doxorubicin,,,,neoplasm,,,,, -8316270,1865,,disrupts,,Doxorubicin,,,,Neoplasm Metastasis,,,,, -24403937,1866,,prevents,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, -23195923,1867,,prevents,,Doxorubicin,,,,lung neoplasm,,,,, -22365593,1868,,prevents,,Doxorubicin,,,,leukemia,,,,, -15227703,1869,,prevents,,Doxorubicin,,,,sarcoma,,,,, -10708896,1870,,prevents,,Doxorubicin,,,,urinary bladder neoplasm,,,,, -8872024,1871,,prevents,,Doxorubicin,,,,Neoplasm Metastasis,,,,, -8737011,1872,,prevents,,Doxorubicin,,,,neutropenia,,,,, -7721507,1873,,prevents,,Doxorubicin,,,,neoplasm,,,,, -18908502,1874,,exacerbates,,Doxorubicin,,,,neoplasm,,,,, -25000938,1875,,predisposes,,Doxorubicin,,,,bone osteosarcoma,,,,, -20426915,1876,,predisposes,,Doxorubicin,,,,neoplasm,,,,, -19669792,1877,,predisposes,,Doxorubicin,,,,sarcoma,,,,, -18137816,1878,,predisposes,,Doxorubicin,,,,lymphoma,,,,, -12722667,1879,,predisposes,,Doxorubicin,,,,acute myeloid leukemia,,,,, -8803332,1880,,predisposes,,Doxorubicin,,,,kidney Wilms tumor,,,,, -7173827,1881,,predisposes,,Doxorubicin,,,,leukemia,,,,, -26966260,1882,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, -26966260,1883,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, -10565399,1884,,physically interacts with,,Iproniazid,,,,Monoamine Oxidase,,,,, -12902070,1885,,affects,,Iproniazid,,,,depressive disorder,,,,, -9833655,1886,,affects,,Iproniazid,,,,Monoamine Oxidase,,,,, -10498318,1887,,related to,,Epirubicin,,,,non-small cell lung carcinoma,,,,, -10228088,1888,,related to,,Epirubicin,,,,ovarian cancer,,,,, -10182077,1889,,related to,,Epirubicin,,,,non-Hodgkin lymphoma,,,,, -10182076,1890,,related to,,Epirubicin,,,,Hodgkins lymphoma,,,,, -8413603,1891,,related to,,Epirubicin,,,,small cell lung carcinoma,,,,, -7746533,1892,,related to,,Epirubicin,,,,castration-resistant prostate carcinoma,,,,, -26737878,1893,,physically interacts with,,Epirubicin,,,,7-Deoxydoxorubicinone,,,,, -18781215,1894,,causes,,Epirubicin,,,,neoplasm,,,,, -26736958,1895,,affects,,Epirubicin,,,,hepatocellular carcinoma,,,,, -12104701,1896,,affects,,Epirubicin,,,,neoplasm,,,,, -14784473,1897,,prevents,,Epirubicin,,,,neoplasm,,,,, -10544897,1898,,physically interacts with,,Nialamide,,,,Monoamine Oxidase,,,,, -9388429,1899,,affects,,Nialamide,,,,Monoamine Oxidase,,,,, -10646811,1900,,affects,,Isocarboxazid,,,,Monoamine Oxidase,,,,, -14451724,1901,,causes,,Valacyclovir,,,,psychotic disorder,,,,, -27205274,1902,,affects,,Valacyclovir,,,,postherpetic neuralgia,,,,, -25557382,1903,,affects,,Valacyclovir,,,,Pregnancy,,,,, -19384061,1904,,disrupts,,Valacyclovir,,,,herpes simplex infectious disease,,,,, -14963245,1905,,disrupts,,Valacyclovir,,,,herpes zoster,,,,, -10778326,1906,,disrupts,,Valacyclovir,,,,viral infectious disease,,,,, -10108851,1907,,disrupts,,Valacyclovir,,,,herpes labialis,,,,, -8112054,1908,,disrupts,,Valacyclovir,,,,genital herpes,,,,, -19368060,1909,,prevents,,Valacyclovir,,,,postherpetic neuralgia,,,,, -12346968,1910,,prevents,,Valacyclovir,,,,genital herpes,,,,, -10108849,1911,,prevents,,Valacyclovir,,,,herpes labialis,,,,, -9970234,1912,,prevents,,Valacyclovir,,,,herpes simplex infectious disease,,,,, -8018684,1913,,prevents,,Valacyclovir,,,,cytomegalovirus infection,,,,, -8899981,1914,,affects,,Cidofovir,,,,cytomegalovirus retinitis,,,,, -7346321,1915,,affects,,Cidofovir,,,,viral infectious disease,,,,, -11567412,1916,,disrupts,,Cidofovir,,,,cytomegalovirus infection,,,,, -27502123,1917,,prevents,,Cidofovir,,,,herpes simplex infectious disease,,,,, -16212718,1918,,prevents,,Cidofovir,,,,cytomegalovirus infection,,,,, -11248462,1919,,prevents,,Cidofovir,,,,viral infectious disease,,,,, -26922185,1920,,affects,,Penciclovir,,,,viral infectious disease,,,,, -22087736,1921,,affects,,Valganciclovir,,,,cytomegalovirus infection,,,,, -18756429,1922,,affects,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, -20121657,1923,,disrupts,,Valganciclovir,,,,cytomegalovirus infection,,,,, -12085189,1924,,prevents,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, -11282399,1925,,prevents,,Valganciclovir,,,,cytomegalovirus infection,,,,, -23156448,1926,,predisposes,,Valganciclovir,,,,kidney disorder,,,,, -20121656,1927,,predisposes,,Valganciclovir,,,,cytomegalovirus infection,,,,, -24607675,1928,,prevents,,Remdesivir,,,,adult acute respiratory distress syndrome,,,,, -18302878,1929,,related to,,Pixantrone,,,,Deoxyribonucleic acid,,,,, -19964229,1930,,affects,,Amrubicin,,,,small cell lung carcinoma,,,,, -15413207,1931,,disrupts,,Amrubicin,,,,neoplasm,,,,, -16523835,1932,,related to,,Sevoflurane,,,,delirium,,,,, -24969850,1933,,causes,,Sevoflurane,,,,adult acute respiratory distress syndrome,,,,, -24682900,1934,,causes,,Sevoflurane,,,,acute kidney failure,,,,, -18232524,1935,,causes,,Sevoflurane,,,,Inflammation,,,,, -17508909,1936,,causes,,Sevoflurane,,,,brain injury,,,,, -17459839,1937,,causes,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -11419059,1938,,causes,,Sevoflurane,,,,delirium,,,,, -7326848,1939,,causes,,Sevoflurane,,,,Pain,,,,, -25308865,1940,,affects,,Sevoflurane,,,,neoplasm,,,,, -25006055,1941,,affects,,Sevoflurane,,,,Pain,,,,, -21710900,1942,,affects,,Sevoflurane,,,,obesity disorder,,,,, -18602416,1943,,affects,,Sevoflurane,,,,delirium,,,,, -17685948,1944,,affects,,Sevoflurane,,,,Pain,,,,, -17508906,1945,,affects,,Sevoflurane,,,,brain injury,,,,, -13563816,1946,,affects,,Sevoflurane,,,,Inflammation,,,,, -7303814,1947,,affects,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -22571416,1948,,disrupts,,Sevoflurane,,,,myocardial infarction,,,,, -22138617,1949,,disrupts,,Sevoflurane,,,,brain injury,,,,, -19949689,1950,,disrupts,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -17977822,1951,,disrupts,,Sevoflurane,,,,Inflammation,,,,, -24348187,1952,,prevents,,Sevoflurane,,,,acute kidney failure,,,,, -24204877,1953,,prevents,,Sevoflurane,,,,neoplasm,,,,, -20028749,1954,,prevents,,Sevoflurane,,,,delirium,,,,, -19290567,1955,,prevents,,Sevoflurane,,,,Pain,,,,, -16830216,1956,,prevents,,Sevoflurane,,,,Inflammation,,,,, -11671117,1957,,prevents,,Sevoflurane,,,,brain injury,,,,, -9664903,1958,,prevents,,Sevoflurane,,,,ischemia reperfusion injury,,,,, -18320093,1959,,predisposes,,Sevoflurane,,,,delirium,,,,, -18121347,1960,,predisposes,,Sevoflurane,,,,Inflammation,,,,, -24455592,1961,,causes,,Desflurane,,,,Postoperative Complications,,,,, -16095968,1962,,related to,,Heroin,,,,heroin dependence,,,,, -9440915,1963,,related to,,Heroin,,,,opiate dependence,,,,, -18531996,1964,,causes,,Heroin,,,,heroin dependence,,,,, -14784390,1965,,causes,,Heroin,,,,opiate dependence,,,,, -19449218,1966,,related to,,Aluminum hydroxide,,,,type 1 diabetes mellitus,,,,, -19135529,1967,,related to,,Aluminum hydroxide,,,,malaria,,,,, -18758930,1968,,related to,,Aluminum hydroxide,,,,influenza,,,,, -15398111,1969,,prevents,,Aluminum hydroxide,,,,stomatitis,,,,, -15812884,1970,,related to,,Methadone,,,,heroin dependence,,,,, -19260564,1971,,causes,,Methadone,,,,neonatal abstinence syndrome,,,,, -18130331,1972,,causes,,Methadone,,,,neuralgia,,,,, -18100345,1973,,causes,,Methadone,,,,Pain,,,,, -21405277,1974,,affects,,Methadone,,,,opiate dependence,,,,, -21075382,1975,,affects,,Methadone,,,,neoplasm,,,,, -20010980,1976,,affects,,Methadone,,,,Premature birth,,,,, -18302283,1977,,affects,,Methadone,,,,Pain,,,,, -18207522,1978,,affects,,Methadone,,,,neonatal abstinence syndrome,,,,, -18078354,1979,,affects,,Methadone,,,,cocaine dependence,,,,, -11558529,1980,,affects,,Methadone,,,,HIV infectious disease,,,,, -9289228,1981,,affects,,Methadone,,,,HIV infectious disease,,,,, -8979183,1982,,affects,,Methadone,,,,neuralgia,,,,, -16059875,1983,,disrupts,,Methadone,,,,neonatal abstinence syndrome,,,,, -10769844,1984,,disrupts,,Methadone,,,,Pain,,,,, -17766557,1985,,prevents,,Methadone,,,,hepatitis C virus infection,,,,, -15264750,1986,,prevents,,Methadone,,,,opiate dependence,,,,, -8905283,1987,,prevents,,Methadone,,,,Pain,,,,, -8022918,1988,,prevents,,Methadone,,,,neonatal abstinence syndrome,,,,, -26487110,1989,,predisposes,,Methadone,,,,HIV infectious disease,,,,, -15424591,1990,,predisposes,,Methadone,,,,neonatal abstinence syndrome,,,,, -14491460,1991,,predisposes,,Methadone,,,,Premature birth,,,,, -26386166,1992,,causes,,Levomethadyl acetate,,,,opiate dependence,,,,, -26901861,1993,,prevents,,Halofantrine,,,,malaria,,,,, -27668107,1994,,related to,,Erythropoietin,,,,HIV infectious disease,,,,, -24695634,1995,,related to,,Erythropoietin,,,,optic nerve disorder,,,,, -21186290,1996,,related to,,Erythropoietin,,,,Premature birth,,,,, -20871066,1997,,related to,,Erythropoietin,,,,necrotizing enterocolitis,,,,, -18130124,1998,,related to,,Erythropoietin,,,,mood disorder,,,,, -17186873,1999,,related to,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, -16980950,2000,,related to,,Erythropoietin,,,,acute myeloid leukemia,,,,, -16468663,2001,,related to,,Erythropoietin,,,,optic neuritis,,,,, -16173384,2002,,related to,,Erythropoietin,,,,Friedreich ataxia,,,,, -15054484,2003,,related to,,Erythropoietin,,,,breast neoplasm,,,,, -14004775,2004,,related to,,Erythropoietin,,,,malaria,,,,, -13955435,2005,,related to,,Erythropoietin,,,,chronic renal failure syndrome,,,,, -13624052,2006,,related to,,Erythropoietin,,,,stroke disorder,,,,, -13580694,2007,,related to,,Erythropoietin,,,,Fatigue,,,,, -13206114,2008,,related to,,Erythropoietin,,,,sickle cell anemia,,,,, -12496787,2009,,related to,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, -12188394,2010,,related to,,Erythropoietin,,,,Parkinson disease,,,,, -12126135,2011,,related to,,Erythropoietin,,,,spinal cord injury,,,,, -11923140,2012,,related to,,Erythropoietin,,,,acute kidney failure,,,,, -11799479,2013,,related to,,Erythropoietin,,,,myocardial infarction,,,,, -11734187,2014,,related to,,Erythropoietin,,,,multiple sclerosis,,,,, -11580074,2015,,related to,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -11529882,2016,,related to,,Erythropoietin,,,,myocardial ischemia,,,,, -11452051,2017,,related to,,Erythropoietin,,,,prostate cancer,,,,, -11316441,2018,,related to,,Erythropoietin,,,,Ischemic stroke,,,,, -11293850,2019,,related to,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, -10879812,2020,,related to,,Erythropoietin,,,,hepatitis C virus infection,,,,, -10348029,2021,,related to,,Erythropoietin,,,,neoplasm,,,,, -9392178,2022,,related to,,Erythropoietin,,,,injury,,,,, -9089666,2023,,related to,,Erythropoietin,,,,chronic myelomonocytic leukemia,,,,, -8164061,2024,,related to,,Erythropoietin,,,,myelodysplastic syndrome,,,,, -7458321,2025,,related to,,Erythropoietin,,,,brain ischemia,,,,, -7310369,2026,,related to,,Erythropoietin,,,,anemia,,,,, -7231907,2027,,related to,,Erythropoietin,,,,chronic kidney disease,,,,, -7137476,2028,,related to,,Erythropoietin,,,,kidney failure,,,,, -12479345,2029,,has part,,Erythropoietin,,,,myelodysplastic syndrome,,,,, -9398172,2030,,has part,,Erythropoietin,,,,neoplasm,,,,, -27259307,2031,,causes,,Erythropoietin,,,,acute kidney failure,,,,, -20985522,2032,,causes,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -19282478,2033,,causes,,Erythropoietin,,,,neoplasm,,,,, -19178150,2034,,causes,,Erythropoietin,,,,spinal cord injury,,,,, -18508111,2035,,causes,,Erythropoietin,,,,Parkinson disease,,,,, -16355442,2036,,causes,,Erythropoietin,,,,brain ischemia,,,,, -15387266,2037,,causes,,Erythropoietin,,,,stroke disorder,,,,, -13935957,2038,,causes,,Erythropoietin,,,,injury,,,,, -12824447,2039,,causes,,Erythropoietin,,,,chronic kidney disease,,,,, -11912976,2040,,causes,,Erythropoietin,,,,myocardial infarction,,,,, -11763164,2041,,causes,,Erythropoietin,,,,Fatigue,,,,, -9672360,2042,,causes,,Erythropoietin,,,,kidney failure,,,,, -9370139,2043,,causes,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, -8009177,2044,,causes,,Erythropoietin,,,,anemia,,,,, -26962810,2045,,affects,,Erythropoietin,,,,HIV infectious disease,,,,, -26278974,2046,,affects,,Erythropoietin,,,,sickle cell anemia,,,,, -24983690,2047,,affects,,Erythropoietin,,,,acute myeloid leukemia,,,,, -20885392,2048,,affects,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, -20610677,2049,,affects,,Erythropoietin,,,,stroke disorder,,,,, -18390137,2050,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, -18352546,2051,,affects,,Erythropoietin,,,,injury,,,,, -17607901,2052,,affects,,Erythropoietin,,,,necrotizing enterocolitis,,,,, -15862945,2053,,affects,,Erythropoietin,,,,Ischemic stroke,,,,, -15862785,2054,,affects,,Erythropoietin,,,,malaria,,,,, -15728394,2055,,affects,,Erythropoietin,,,,myocardial infarction,,,,, -15532613,2056,,affects,,Erythropoietin,,,,myocardial infarction,,,,, -12937865,2057,,affects,,Erythropoietin,,,,anemia,,,,, -12867407,2058,,affects,,Erythropoietin,,,,myocardial ischemia,,,,, -11701568,2059,,affects,,Erythropoietin,,,,Fatigue,,,,, -11563361,2060,,affects,,Erythropoietin,,,,neoplasm,,,,, -10970912,2061,,affects,,Erythropoietin,,,,brain injury,,,,, -10068762,2062,,affects,,Erythropoietin,,,,injury,,,,, -9989127,2063,,affects,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -9392180,2064,,affects,,Erythropoietin,,,,spinal cord injury,,,,, -8981317,2065,,affects,,Erythropoietin,,,,brain ischemia,,,,, -7400221,2066,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, -7278560,2067,,affects,,Erythropoietin,,,,anemia,,,,, -27259305,2068,,produces,,Erythropoietin,,,,acute kidney failure,,,,, -26811591,2069,,produces,,Erythropoietin,,,,HIV infectious disease,,,,, -26231858,2070,,produces,,Erythropoietin,,,,lymphoma,,,,, -14673419,2071,,produces,,Erythropoietin,,,,myocardial infarction,,,,, -11452049,2072,,produces,,Erythropoietin,,,,prostate cancer,,,,, -8829207,2073,,produces,,Erythropoietin,,,,neoplasm,,,,, -8032421,2074,,produces,,Erythropoietin,,,,chronic renal failure syndrome,,,,, -8032418,2075,,produces,,Erythropoietin,,,,chronic kidney disease,,,,, -7919214,2076,,produces,,Erythropoietin,,,,anemia,,,,, -7844664,2077,,produces,,Erythropoietin,,,,kidney failure,,,,, -17835656,2078,,disrupts,,Erythropoietin,,,,brain injury,,,,, -17602040,2079,,disrupts,,Erythropoietin,,,,Hemorrhage,,,,, -17384804,2080,,disrupts,,Erythropoietin,,,,Ischemic stroke,,,,, -15027834,2081,,disrupts,,Erythropoietin,,,,Fatigue,,,,, -13243471,2082,,disrupts,,Erythropoietin,,,,chronic kidney disease,,,,, -13033535,2083,,disrupts,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, -11253087,2084,,disrupts,,Erythropoietin,,,,injury,,,,, -8818732,2085,,disrupts,,Erythropoietin,,,,anemia,,,,, -22124183,2086,,prevents,,Erythropoietin,,,,Premature birth,,,,, -19522952,2087,,prevents,,Erythropoietin,,,,Asphyxia,,,,, -17246645,2088,,prevents,,Erythropoietin,,,,cerebral palsy,,,,, -16915551,2089,,prevents,,Erythropoietin,,,,coronary artery disorder,,,,, -16468664,2090,,prevents,,Erythropoietin,,,,optic neuritis,,,,, -16040441,2091,,prevents,,Erythropoietin,,,,spinal cord injury,,,,, -15444373,2092,,prevents,,Erythropoietin,,,,Parkinson disease,,,,, -14252439,2093,,prevents,,Erythropoietin,,,,kidney failure,,,,, -13347324,2094,,prevents,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, -13017739,2095,,prevents,,Erythropoietin,,,,chronic kidney disease,,,,, -11480928,2096,,prevents,,Erythropoietin,,,,Ischemic stroke,,,,, -11148609,2097,,prevents,,Erythropoietin,,,,myocardial ischemia,,,,, -11115141,2098,,prevents,,Erythropoietin,,,,stroke disorder,,,,, -10838253,2099,,prevents,,Erythropoietin,,,,necrotizing enterocolitis,,,,, -10766440,2100,,prevents,,Erythropoietin,,,,myocardial infarction,,,,, -10125087,2101,,prevents,,Erythropoietin,,,,ischemia reperfusion injury,,,,, -8434315,2102,,prevents,,Erythropoietin,,,,injury,,,,, -8405867,2103,,prevents,,Erythropoietin,,,,brain ischemia,,,,, -8369017,2104,,prevents,,Erythropoietin,,,,brain injury,,,,, -7400218,2105,,prevents,,Erythropoietin,,,,Fatigue,,,,, -7236347,2106,,prevents,,Erythropoietin,,,,anemia,,,,, -18610239,2107,,exacerbates,,Erythropoietin,,,,injury,,,,, -14126866,2108,,exacerbates,,Erythropoietin,,,,anemia,,,,, -25818939,2109,,predisposes,,Erythropoietin,,,,neoplasm,,,,, -19869298,2110,,predisposes,,Erythropoietin,,,,coronary artery disorder,,,,, -19564296,2111,,predisposes,,Erythropoietin,,,,Asphyxia,,,,, -19270398,2112,,predisposes,,Erythropoietin,,,,brain injury,,,,, -18282528,2113,,predisposes,,Erythropoietin,,,,chronic kidney disease,,,,, -16056103,2114,,predisposes,,Erythropoietin,,,,Ischemic stroke,,,,, -14483144,2115,,predisposes,,Erythropoietin,,,,injury,,,,, -12166360,2116,,predisposes,,Erythropoietin,,,,kidney failure,,,,, -8361116,2117,,predisposes,,Erythropoietin,,,,anemia,,,,, -24327196,2118,,affects,,Daprodustat,,,,anemia,,,,, -24574810,2119,,prevents,,Daprodustat,,,,anemia,,,,, -19595886,2120,,related to,,mecobalamin,,,,vitamin B12 deficiency,,,,, -13417310,2121,,related to,,mecobalamin,,,,amyotrophic lateral sclerosis,,,,, -26391120,2122,,related to,,vitamin B12,,,,myocardial infarction,,,,, -21860699,2123,,related to,,vitamin B12,,,,type 2 diabetes mellitus,,,,, -20662929,2124,,related to,,vitamin B12,,,,non-small cell lung carcinoma,,,,, -19346996,2125,,related to,,vitamin B12,,,,myocardial ischemia,,,,, -12974621,2126,,related to,,vitamin B12,,,,osteoporosis,,,,, -10934739,2127,,related to,,vitamin B12,,,,chronic kidney disease,,,,, -10883089,2128,,related to,,vitamin B12,,,,depressive disorder,,,,, -10658870,2129,,related to,,vitamin B12,,,,psoriasis,,,,, -10535786,2130,,related to,,vitamin B12,,,,atherosclerosis,,,,, -10535188,2131,,related to,,vitamin B12,,,,lymphoma,,,,, -10508686,2132,,related to,,vitamin B12,,,,vitamin B12 deficiency,,,,, -10438501,2133,,related to,,vitamin B12,,,,iron deficiency anemia,,,,, -9977774,2134,,related to,,vitamin B12,,,,psychotic disorder,,,,, -9644935,2135,,related to,,vitamin B12,,,,anemia,,,,, -9118739,2136,,related to,,vitamin B12,,,,Low back pain,,,,, -8678107,2137,,related to,,vitamin B12,,,,Alzheimer disease,,,,, -27330642,2138,,causes,,vitamin B12,,,,depressive disorder,,,,, -26003936,2139,,causes,,vitamin B12,,,,diabetic neuropathy,,,,, -17687811,2140,,causes,,vitamin B12,,,,osteoporosis,,,,, -11993792,2141,,causes,,vitamin B12,,,,Reduced blood folate concentration,,,,, -10806959,2142,,causes,,vitamin B12,,,,psychotic disorder,,,,, -10716413,2143,,causes,,vitamin B12,,,,vitamin B12 deficiency,,,,, -9828196,2144,,causes,,vitamin B12,,,,anemia,,,,, -7900732,2145,,causes,,vitamin B12,,,,atherosclerosis,,,,, -25091008,2146,,affects,,vitamin B12,,,,HIV infectious disease,,,,, -20098295,2147,,affects,,vitamin B12,,,,depressive disorder,,,,, -19763864,2148,,affects,,vitamin B12,,,,Alzheimer disease,,,,, -18490813,2149,,affects,,vitamin B12,,,,depressive disorder,,,,, -17348852,2150,,affects,,vitamin B12,,,,vitamin B12 deficiency,,,,, -16930257,2151,,affects,,vitamin B12,,,,amyotrophic lateral sclerosis,,,,, -13607058,2152,,affects,,vitamin B12,,,,depressive disorder,,,,, -12773836,2153,,affects,,vitamin B12,,,,atherosclerosis,,,,, -11945900,2154,,affects,,vitamin B12,,,,Pregnancy,,,,, -11927611,2155,,affects,,vitamin B12,,,,diabetic neuropathy,,,,, -10798681,2156,,affects,,vitamin B12,,,,type 2 diabetes mellitus,,,,, -10424959,2157,,affects,,vitamin B12,,,,anemia,,,,, -8733280,2158,,affects,,vitamin B12,,,,Pregnancy,,,,, -8015838,2159,,affects,,vitamin B12,,,,chronic kidney disease,,,,, -23636866,2160,,produces,,vitamin B12,,,,vitamin B12 deficiency,,,,, -11124683,2161,,disrupts,,vitamin B12,,,,chronic kidney disease,,,,, -20603701,2162,,prevents,,vitamin B12,,,,Alzheimer disease,,,,, -14586818,2163,,prevents,,vitamin B12,,,,anemia,,,,, -10782972,2164,,prevents,,vitamin B12,,,,atherosclerosis,,,,, -9545669,2165,,prevents,,vitamin B12,,,,vitamin B12 deficiency,,,,, -27415421,2166,,predisposes,,vitamin B12,,,,myocardial infarction,,,,, -21063265,2167,,predisposes,,vitamin B12,,,,depressive disorder,,,,, -20875915,2168,,predisposes,,vitamin B12,,,,chronic kidney disease,,,,, -15081186,2169,,predisposes,,vitamin B12,,,,osteoporosis,,,,, -12678935,2170,,predisposes,,vitamin B12,,,,atherosclerosis,,,,, -12664527,2171,,predisposes,,vitamin B12,,,,Alzheimer disease,,,,, -8590188,2172,,predisposes,,vitamin B12,,,,anemia,,,,, -22149451,2173,,affects,,Ipragliflozin,,,,type 2 diabetes mellitus,,,,, -24120079,2174,,disrupts,,Ertugliflozin,,,,diabetes mellitus,,,,, -23006843,2175,,related to,,Empagliflozin,,,,diabetes mellitus,,,,, -22183651,2176,,related to,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, -24924157,2177,,causes,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, -23515975,2178,,causes,,Empagliflozin,,,,myocardial infarction,,,,, -23240834,2179,,causes,,Empagliflozin,,,,acute kidney failure,,,,, -25094844,2180,,affects,,Empagliflozin,,,,diabetes mellitus,,,,, -24520517,2181,,affects,,Empagliflozin,,,,Insulin resistance,,,,, -24184835,2182,,affects,,Empagliflozin,,,,diabetic kidney disease,,,,, -24091231,2183,,affects,,Empagliflozin,,,,kidney disorder,,,,, -22935616,2184,,affects,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, -22175650,2185,,affects,,Empagliflozin,,,,acute kidney failure,,,,, -22027265,2186,,affects,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, -21867589,2187,,affects,,Empagliflozin,,,,myocardial infarction,,,,, -21618629,2188,,affects,,Empagliflozin,,,,pulmonary arterial hypertension,,,,, -22842915,2189,,disrupts,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, -23528682,2190,,prevents,,Empagliflozin,,,,myocardial infarction,,,,, -23286446,2191,,prevents,,Empagliflozin,,,,acute kidney failure,,,,, -24551007,2192,,predisposes,,Empagliflozin,,,,acute kidney failure,,,,, -24497752,2193,,predisposes,,Empagliflozin,,,,hypoglycemia,,,,, -23163444,2194,,predisposes,,Empagliflozin,,,,diabetic kidney disease,,,,, -21786786,2195,,related to,,Dapagliflozin,,,,Alzheimer disease,,,,, -23582915,2196,,causes,,Dapagliflozin,,,,Weight loss,,,,, -25156234,2197,,affects,,Dapagliflozin,,,,non-alcoholic fatty liver disease,,,,, -23530734,2198,,affects,,Dapagliflozin,,,,Albuminuria,,,,, -23107287,2199,,affects,,Dapagliflozin,,,,type 1 diabetes mellitus,,,,, -23072376,2200,,affects,,Dapagliflozin,,,,ischemia reperfusion injury,,,,, -22916804,2201,,affects,,Dapagliflozin,,,,diabetic kidney disease,,,,, -22845588,2202,,affects,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, -22578057,2203,,affects,,Dapagliflozin,,,,Albuminuria,,,,, -22163310,2204,,affects,,Dapagliflozin,,,,Weight loss,,,,, -21622453,2205,,affects,,Dapagliflozin,,,,atrial fibrillation,,,,, -25362847,2206,,disrupts,,Dapagliflozin,,,,acute kidney failure,,,,, -23258105,2207,,disrupts,,Dapagliflozin,,,,kidney failure,,,,, -22845589,2208,,disrupts,,Dapagliflozin,,,,diabetes mellitus,,,,, -23973238,2209,,prevents,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, -23528684,2210,,prevents,,Dapagliflozin,,,,myocardial infarction,,,,, -23138841,2211,,prevents,,Dapagliflozin,,,,diabetic kidney disease,,,,, -22845590,2212,,prevents,,Dapagliflozin,,,,diabetes mellitus,,,,, -22832530,2213,,prevents,,Dapagliflozin,,,,kidney failure,,,,, -21513723,2214,,prevents,,Dapagliflozin,,,,obesity disorder,,,,, -25236689,2215,,predisposes,,Dapagliflozin,,,,kidney failure,,,,, -23072379,2216,,predisposes,,Dapagliflozin,,,,myocardial infarction,,,,, -20833370,2217,,related to,,Methyldopa,,,,type 1 diabetes mellitus,,,,, -15433400,2218,,related to,,Methyldopa,,,,preeclampsia,,,,, -7364754,2219,,related to,,Methyldopa,,,,hypertensive disorder,,,,, -25805913,2220,,causes,,Methyldopa,,,,hypertensive disorder,,,,, -23430063,2221,,causes,,Methyldopa,,,,preeclampsia,,,,, -26257846,2222,,affects,,Methyldopa,,,,hypertensive disorder,,,,, -10671192,2223,,affects,,Methyldopa,,,,hypertensive disorder,,,,, -26170425,2224,,prevents,,Methyldopa,,,,hypertensive disorder,,,,, -8219214,2225,,exacerbates,,Methyldopa,,,,hypertensive disorder,,,,, -20611289,2226,,predisposes,,Methyldopa,,,,preeclampsia,,,,, -19343164,2227,,related to,,Exemestane,,,,male breast carcinoma,,,,, -14849934,2228,,related to,,Exemestane,,,,ductal breast carcinoma in situ,,,,, -14694867,2229,,related to,,Exemestane,,,,non-small cell lung carcinoma,,,,, -11511167,2230,,related to,,Exemestane,,,,neoplasm,,,,, -18732584,2231,,affects,,Exemestane,,,,neoplasm,,,,, -14063167,2232,,affects,,Exemestane,,,,neoplasm,,,,, -16053578,2233,,prevents,,Exemestane,,,,breast neoplasm,,,,, -20235097,2234,,disrupts,,Rivizor,,,,neoplasm,,,,, -24226617,2235,,related to,,Letrozole,,,,polycystic ovary syndrome,,,,, -19925368,2236,,related to,,Letrozole,,,,infertility disorder,,,,, -13004646,2237,,related to,,Letrozole,,,,endometriosis,,,,, -11511165,2238,,related to,,Letrozole,,,,neoplasm,,,,, -22485512,2239,,causes,,Letrozole,,,,infertility disorder,,,,, -17708157,2240,,causes,,Letrozole,,,,neoplasm,,,,, -14659251,2241,,causes,,Letrozole,,,,endometriosis,,,,, -11078418,2242,,causes,,Letrozole,,,,polycystic ovary syndrome,,,,, -10282160,2243,,causes,,Letrozole,,,,hypogonadism,,,,, -25205942,2244,,affects,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, -18870552,2245,,affects,,Letrozole,,,,Pregnancy,,,,, -18835925,2246,,affects,,Letrozole,,,,inflammatory breast carcinoma,,,,, -10866444,2247,,affects,,Letrozole,,,,Pregnancy,,,,, -7871182,2248,,affects,,Letrozole,,,,neoplasm,,,,, -21352213,2249,,disrupts,,Letrozole,,,,Pregnancy,,,,, -25448977,2250,,prevents,,Letrozole,,,,prostate cancer,,,,, -19305611,2251,,prevents,,Letrozole,,,,Spontaneous abortion,,,,, -17892609,2252,,prevents,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, -13373696,2253,,prevents,,Letrozole,,,,neoplasm,,,,, -20363763,2254,,predisposes,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, -19305612,2255,,predisposes,,Letrozole,,,,Spontaneous abortion,,,,, -26765214,2256,,affects,,Formestane,,,,neoplasm,,,,, -25526748,2257,,disrupts,,Formestane,,,,neoplasm,,,,, -13022860,2258,,prevents,,Formestane,,,,neoplasm,,,,, -26325498,2259,,affects,,Aminoglutethimide,,,,neoplasm,,,,, -12185634,2260,,affects,,Aminoglutethimide,,,,neoplasm,,,,, -22275813,2261,,related to,,Relugolix,,,,prostate cancer,,,,, -23469407,2262,,prevents,,Relugolix,,,,Pain,,,,, -25422975,2263,,related to,,Abiraterone,,,,castration-resistant prostate carcinoma,,,,, -20717678,2264,,related to,,Abiraterone,,,,prostate cancer,,,,, -16721978,2265,,affects,,Abiraterone,,,,prostate cancer,,,,, -15794241,2266,,prevents,,Abiraterone,,,,neoplasm,,,,, -19010753,2267,,predisposes,,Abiraterone,,,,prostate cancer,,,,, -11344546,2268,,related to,,Finasteride,,,,acne,,,,, -11344545,2269,,related to,,Finasteride,,,,alopecia,,,,, -9840638,2270,,related to,,Finasteride,,,,prostate cancer,,,,, -7359591,2271,,related to,,Finasteride,,,,benign prostatic hyperplasia,,,,, -21759063,2272,,causes,,Finasteride,,,,benign prostatic hyperplasia,,,,, -11694493,2273,,causes,,Finasteride,,,,prostate cancer,,,,, -11326933,2274,,affects,,Finasteride,,,,prostate cancer,,,,, -9873046,2275,,affects,,Finasteride,,,,benign prostatic hyperplasia,,,,, -9845785,2276,,affects,,Finasteride,,,,alopecia,,,,, -7857572,2277,,affects,,Finasteride,,,,prostate cancer,,,,, -21155186,2278,,disrupts,,Finasteride,,,,benign prostatic hyperplasia,,,,, -10949204,2279,,disrupts,,Finasteride,,,,prostate cancer,,,,, -7931250,2280,,disrupts,,Finasteride,,,,alopecia,,,,, -11279550,2281,,prevents,,Finasteride,,,,benign prostatic hyperplasia,,,,, -8938663,2282,,prevents,,Finasteride,,,,alopecia,,,,, -7857569,2283,,prevents,,Finasteride,,,,prostate cancer,,,,, -9840634,2284,,predisposes,,Finasteride,,,,prostate cancer,,,,, -8913536,2285,,predisposes,,Finasteride,,,,benign prostatic hyperplasia,,,,, -15677403,2286,,related to,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -14665250,2287,,related to,,Dutasteride,,,,prostate cancer,,,,, -22506276,2288,,causes,,Dutasteride,,,,prostatitis,,,,, -14995448,2289,,affects,,Dutasteride,,,,prostate cancer,,,,, -11407079,2290,,affects,,Dutasteride,,,,prostatitis,,,,, -10333399,2291,,affects,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -15838005,2292,,disrupts,,Dutasteride,,,,prostate cancer,,,,, -16876475,2293,,prevents,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -13018366,2294,,prevents,,Dutasteride,,,,alopecia,,,,, -12506526,2295,,prevents,,Dutasteride,,,,prostate cancer,,,,, -13749427,2296,,predisposes,,Dutasteride,,,,benign prostatic hyperplasia,,,,, -13628345,2297,,predisposes,,Dutasteride,,,,prostate cancer,,,,, -23122900,2298,,related to,,Celecoxib,,,,Pain,,,,, -20821764,2299,,related to,,Celecoxib,,,,prostate cancer,,,,, -14485082,2300,,related to,,Celecoxib,,,,castration-resistant prostate carcinoma,,,,, -14288130,2301,,related to,,Celecoxib,,,,neoplasm,,,,, -15210658,2302,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, -15210658,2303,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11056859,2304,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11056859,2305,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -19664582,2306,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -19664582,2307,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -8460221,2308,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -9140190,2309,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, -22101111,2310,,causes,,Celecoxib,,,,Alzheimer disease,,,,, -21110777,2311,,causes,,Celecoxib,,,,schizophrenia,,,,, -20555672,2312,,causes,,Celecoxib,,,,hepatocellular carcinoma,,,,, -14478589,2313,,causes,,Celecoxib,,,,Inflammation,,,,, -14396158,2314,,causes,,Celecoxib,,,,neoplasm,,,,, -13894212,2315,,causes,,Celecoxib,,,,peptic ulcer disease,,,,, -13829410,2316,,causes,,Celecoxib,,,,Pain,,,,, -12882318,2317,,causes,,Celecoxib,,,,colorectal neoplasm,,,,, -12147702,2318,,causes,,Celecoxib,,,,osteoarthritis,,,,, -12029200,2319,,causes,,Celecoxib,,,,Hemorrhage,,,,, -10018014,2320,,causes,,Celecoxib,,,,hypertensive disorder,,,,, -25555760,2321,,affects,,Celecoxib,,,,postpartum depression,,,,, -21116356,2322,,affects,,Celecoxib,,,,major depressive disorder,,,,, -19634803,2323,,affects,,Celecoxib,,,,Hemorrhage,,,,, -18087191,2324,,affects,,Celecoxib,,,,breast neoplasm,,,,, -17669654,2325,,affects,,Celecoxib,,,,glioma,,,,, -17634409,2326,,affects,,Celecoxib,,,,depressive disorder,,,,, -16787676,2327,,affects,,Celecoxib,,,,hypertensive disorder,,,,, -15889622,2328,,affects,,Celecoxib,,,,osteoarthritis,,,,, -13667242,2329,,affects,,Celecoxib,,,,obesity disorder,,,,, -13414910,2330,,affects,,Celecoxib,,,,Hemorrhage,,,,, -13122831,2331,,affects,,Celecoxib,,,,hypertensive disorder,,,,, -12419082,2332,,affects,,Celecoxib,,,,neoplasm,,,,, -11947530,2333,,affects,,Celecoxib,,,,hepatocellular carcinoma,,,,, -11444192,2334,,affects,,Celecoxib,,,,neoplasm,,,,, -11303331,2335,,affects,,Celecoxib,,,,non-small cell lung carcinoma,,,,, -10337670,2336,,affects,,Celecoxib,,,,colorectal neoplasm,,,,, -10157341,2337,,affects,,Celecoxib,,,,injury,,,,, -9967873,2338,,affects,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -9574485,2339,,affects,,Celecoxib,,,,schizophrenia,,,,, -9038473,2340,,affects,,Celecoxib,,,,peptic ulcer disease,,,,, -7841958,2341,,affects,,Celecoxib,,,,rheumatoid arthritis,,,,, -7726669,2342,,affects,,Celecoxib,,,,Pain,,,,, -7726668,2343,,affects,,Celecoxib,,,,Inflammation,,,,, -7264055,2344,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11464194,2345,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11846592,2346,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, -11846592,2347,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, -14865798,2348,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, -14865798,2349,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, -22029254,2350,,disrupts,,Celecoxib,,,,major depressive disorder,,,,, -16862201,2351,,disrupts,,Celecoxib,,,,hepatocellular carcinoma,,,,, -15337601,2352,,disrupts,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -15029907,2353,,disrupts,,Celecoxib,,,,Pain,,,,, -14234726,2354,,disrupts,,Celecoxib,,,,adenoma,,,,, -12025752,2355,,disrupts,,Celecoxib,,,,colonic neoplasm,,,,, -9589598,2356,,disrupts,,Celecoxib,,,,neoplasm,,,,, -9384934,2357,,disrupts,,Celecoxib,,,,breast neoplasm,,,,, -8528907,2358,,disrupts,,Celecoxib,,,,Inflammation,,,,, -19393781,2359,,prevents,,Celecoxib,,,,stroke disorder,,,,, -18309561,2360,,prevents,,Celecoxib,,,,hepatocellular carcinoma,,,,, -17468664,2361,,prevents,,Celecoxib,,,,non-small cell lung carcinoma,,,,, -16386169,2362,,prevents,,Celecoxib,,,,actinic keratosis,,,,, -16323754,2363,,prevents,,Celecoxib,,,,hypertensive disorder,,,,, -15947575,2364,,prevents,,Celecoxib,,,,osteoarthritis,,,,, -15337603,2365,,prevents,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, -14688780,2366,,prevents,,Celecoxib,,,,Low back pain,,,,, -13346756,2367,,prevents,,Celecoxib,,,,prostate cancer,,,,, -12969778,2368,,prevents,,Celecoxib,,,,neuroblastoma,,,,, -12687466,2369,,prevents,,Celecoxib,,,,adenoma,,,,, -11060421,2370,,prevents,,Celecoxib,,,,classic familial adenomatous polyposis,,,,, -10931690,2371,,prevents,,Celecoxib,,,,breast neoplasm,,,,, -10337661,2372,,prevents,,Celecoxib,,,,colorectal neoplasm,,,,, -9969498,2373,,prevents,,Celecoxib,,,,Acute Pain,,,,, -9525867,2374,,prevents,,Celecoxib,,,,injury,,,,, -9508533,2375,,prevents,,Celecoxib,,,,Pain,,,,, -8844228,2376,,prevents,,Celecoxib,,,,Inflammation,,,,, -7720173,2377,,prevents,,Celecoxib,,,,neoplasm,,,,, -14426267,2378,,predisposes,,Celecoxib,,,,Inflammation,,,,, -12799788,2379,,predisposes,,Celecoxib,,,,hypertensive disorder,,,,, -11130431,2380,,predisposes,,Celecoxib,,,,injury,,,,, -12352394,2381,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -12352394,2382,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -14685035,2383,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -14685035,2384,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -8460222,2385,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -9140191,2386,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -10265772,2387,,causes,,Rofecoxib,,,,Pain,,,,, -13140649,2388,,affects,,Rofecoxib,,,,Pain,,,,, -13143485,2389,,affects,,Rofecoxib,,,,osteoarthritis,,,,, -12129893,2390,,affects,,Rofecoxib,,,,adenoma,,,,, -11539323,2391,,affects,,Rofecoxib,,,,Pain,,,,, -10337671,2392,,affects,,Rofecoxib,,,,colorectal neoplasm,,,,, -8436303,2393,,affects,,Rofecoxib,,,,osteoarthritis,,,,, -7546790,2394,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -11143316,2395,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, -11899486,2396,,disrupts,,Rofecoxib,,,,Pain,,,,, -12422414,2397,,prevents,,Rofecoxib,,,,adenoma,,,,, -10337662,2398,,prevents,,Rofecoxib,,,,colorectal neoplasm,,,,, -9488144,2399,,prevents,,Rofecoxib,,,,Pain,,,,, -12808149,2400,,predisposes,,Rofecoxib,,,,adenoma,,,,, -21440548,2401,,affects,,Etoricoxib,,,,osteoarthritis,,,,, -17783506,2402,,affects,,Etoricoxib,,,,injury,,,,, -15015650,2403,,affects,,Etoricoxib,,,,Pain,,,,, -13276651,2404,,affects,,Etoricoxib,,,,rheumatic disorder,,,,, -8656381,2405,,affects,,Etoricoxib,,,,Cyclooxygenase 2,,,,, -21271381,2406,,prevents,,Etoricoxib,,,,osteoarthritis,,,,, -17783508,2407,,prevents,,Etoricoxib,,,,injury,,,,, -13679347,2408,,prevents,,Etoricoxib,,,,Pain,,,,, -11619190,2409,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -11619190,2410,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -17164065,2411,,physically interacts with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -13276652,2412,,affects,,Lumiracoxib,,,,rheumatic disorder,,,,, -10245332,2413,,affects,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, -13077914,2414,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, -11476053,2415,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, -9552647,2416,,affects,,Valdecoxib,,,,Cyclooxygenase 2,,,,, -11215677,2417,,disrupts,,Valdecoxib,,,,Pain,,,,, -15156435,2418,,prevents,,Valdecoxib,,,,pancreatitis,,,,, -10035578,2419,,prevents,,Valdecoxib,,,,Pain,,,,, -17909160,2420,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, -17909160,2421,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, -16597136,2422,,affects,,Parecoxib,,,,Shoulder pain,,,,, -13492238,2423,,affects,,Parecoxib,,,,Pain,,,,, -12600950,2424,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, -18579418,2425,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, -18207264,2426,,disrupts,,Parecoxib,,,,Pain,,,,, -16597135,2427,,prevents,,Parecoxib,,,,Shoulder pain,,,,, -14081775,2428,,prevents,,Parecoxib,,,,Pain,,,,, -22281663,2429,,related to,,Drospirenone,,,,polycystic ovary syndrome,,,,, -21546756,2430,,related to,,Drospirenone,,,,acne,,,,, -20964606,2431,,predisposes,,Drospirenone,,,,polycystic ovary syndrome,,,,, -8455182,2432,,related to,,Ropinirole,,,,Parkinson disease,,,,, -17774585,2433,,causes,,Ropinirole,,,,Parkinson disease,,,,, -14587825,2434,,affects,,Ropinirole,,,,Parkinson disease,,,,, -11791368,2435,,affects,,Ropinirole,,,,restless legs syndrome,,,,, -9334943,2436,,disrupts,,Ropinirole,,,,Parkinson disease,,,,, -10286489,2437,,prevents,,Ropinirole,,,,Parkinson disease,,,,, -27727471,2438,,related to,,Pergolide,,,,Parkinson disease,,,,, -11914502,2439,,causes,,Pergolide,,,,Parkinson disease,,,,, -10881399,2440,,affects,,Pergolide,,,,Parkinson disease,,,,, -16163315,2441,,related to,,Bromocriptine,,,,Parkinson disease,,,,, -15233295,2442,,related to,,Bromocriptine,,,,type 1 diabetes mellitus,,,,, -17352665,2443,,causes,,Bromocriptine,,,,obesity disorder,,,,, -12630193,2444,,causes,,Bromocriptine,,,,Parkinson disease,,,,, -22488533,2445,,affects,,Bromocriptine,,,,adenomyosis,,,,, -20888778,2446,,affects,,Bromocriptine,,,,Parkinson disease,,,,, -27647530,2447,,prevents,,Bromocriptine,,,,obesity disorder,,,,, -15529387,2448,,prevents,,Bromocriptine,,,,ovarian hyperstimulation syndrome,,,,, -18216941,2449,,causes,,Piribedil,,,,Parkinson disease,,,,, -8408670,2450,,affects,,Piribedil,,,,Parkinson disease,,,,, -8818724,2451,,related to,,Apomorphine,,,,Parkinson disease,,,,, -23018637,2452,,causes,,Apomorphine,,,,erectile dysfunction,,,,, -11364291,2453,,causes,,Apomorphine,,,,Parkinson disease,,,,, -8320181,2454,,affects,,Apomorphine,,,,Parkinson disease,,,,, -16869339,2455,,related to,,Cabergoline,,,,Parkinson disease,,,,, -19536611,2456,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, -15320456,2457,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, -20751353,2458,,causes,,Cabergoline,,,,endometriosis,,,,, -26585560,2459,,affects,,Cabergoline,,,,pituitary tumor,,,,, -19237315,2460,,affects,,Cabergoline,,,,endometriosis,,,,, -17463083,2461,,affects,,Cabergoline,,,,Dopamine D2 Receptor,,,,, -12695381,2462,,affects,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, -13380476,2463,,prevents,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, -9194241,2464,,predisposes,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, -15982499,2465,,related to,,Pramipexole,,,,restless legs syndrome,,,,, -9735890,2466,,related to,,Pramipexole,,,,Parkinson disease,,,,, -21401262,2467,,causes,,Pramipexole,,,,restless legs syndrome,,,,, -15033700,2468,,causes,,Pramipexole,,,,obsessive-compulsive disorder,,,,, -13328857,2469,,causes,,Pramipexole,,,,Parkinson disease,,,,, -18143671,2470,,affects,,Pramipexole,,,,depressive disorder,,,,, -12990655,2471,,affects,,Pramipexole,,,,restless legs syndrome,,,,, -12579916,2472,,affects,,Pramipexole,,,,depressive disorder,,,,, -10881401,2473,,affects,,Pramipexole,,,,Parkinson disease,,,,, -11457313,2474,,prevents,,Pramipexole,,,,Parkinson disease,,,,, -24610805,2475,,affects,,Rotigotine,,,,Parkinson disease,,,,, -10840977,2476,,subclass of,,Norethindrone,,,,Norethindrone acetate,,,,, -8232443,2477,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, -11686400,2478,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, -9474851,2479,,coexists with,,Norethindrone,,,,Norethindrone acetate,,,,, -9781055,2480,,physically interacts with,,Norethindrone,,,,Norethindrone acetate,,,,, -21462883,2481,,causes,,Norethindrone,,,,neoplasm,,,,, -27429354,2482,,affects,,Pramocaine,,,,Pruritus,,,,, -19275366,2483,,disrupts,,Miconazole,,,,fungal infectious disease,,,,, -26511975,2484,,prevents,,Miconazole,,,,fungal infectious disease,,,,, -26530559,2485,,affects,,Benzocaine,,,,Pain,,,,, -8870493,2486,,disrupts,,Benzocaine,,,,Pain,,,,, -8870496,2487,,prevents,,Benzocaine,,,,Pain,,,,, -25561815,2488,,related to,,Folic Acid,,,,systemic lupus erythematosus,,,,, -23703706,2489,,related to,,Folic Acid,,,,neoplasm of esophagus,,,,, -23248765,2490,,related to,,Folic Acid,,,,chronic renal failure syndrome,,,,, -20038856,2491,,related to,,Folic Acid,,,,psychotic disorder,,,,, -19346997,2492,,related to,,Folic Acid,,,,myocardial ischemia,,,,, -19301020,2493,,related to,,Folic Acid,,,,type 2 diabetes mellitus,,,,, -19114314,2494,,related to,,Folic Acid,,,,tuberculosis,,,,, -18323097,2495,,related to,,Folic Acid,,,,HIV infectious disease,,,,, -17591518,2496,,related to,,Folic Acid,,,,infertility disorder,,,,, -15826430,2497,,related to,,Folic Acid,,,,male infertility,,,,, -14280104,2498,,related to,,Folic Acid,,,,myocardial infarction,,,,, -12974622,2499,,related to,,Folic Acid,,,,osteoporosis,,,,, -12112288,2500,,related to,,Folic Acid,,,,autism spectrum disorder,,,,, -11305980,2501,,related to,,Folic Acid,,,,cleft palate,,,,, -10745702,2502,,related to,,Folic Acid,,,,malaria,,,,, -10717915,2503,,related to,,Folic Acid,,,,habitual spontaneous abortion,,,,, -10644755,2504,,related to,,Folic Acid,,,,atherosclerosis,,,,, -10226420,2505,,related to,,Folic Acid,,,,cervical polyp,,,,, -10177078,2506,,related to,,Folic Acid,,,,colorectal neoplasm,,,,, -10046990,2507,,related to,,Folic Acid,,,,depressive disorder,,,,, -9815747,2508,,related to,,Folic Acid,,,,hypertensive disorder,,,,, -9628243,2509,,related to,,Folic Acid,,,,mesothelioma,,,,, -9628242,2510,,related to,,Folic Acid,,,,non-small cell lung carcinoma,,,,, -9060030,2511,,related to,,Folic Acid,,,,neoplasm,,,,, -8875457,2512,,related to,,Folic Acid,,,,lymphoma,,,,, -8584638,2513,,related to,,Folic Acid,,,,sickle cell anemia,,,,, -8274471,2514,,related to,,Folic Acid,,,,chronic kidney disease,,,,, -8259960,2515,,related to,,Folic Acid,,,,type 1 diabetes mellitus,,,,, -8078141,2516,,related to,,Folic Acid,,,,Alzheimer disease,,,,, -7868306,2517,,related to,,Folic Acid,,,,coronary artery disorder,,,,, -7765942,2518,,related to,,Folic Acid,,,,anemia,,,,, -7303518,2519,,related to,,Folic Acid,,,,epilepsy,,,,, -7234301,2520,,related to,,Folic Acid,,,,Reduced blood folate concentration,,,,, -7229825,2521,,related to,,Folic Acid,,,,iron deficiency anemia,,,,, -7175279,2522,,related to,,Folic Acid,,,,rheumatoid arthritis,,,,, -25522909,2523,,causes,,Folic Acid,,,,diabetic kidney disease,,,,, -18689556,2524,,causes,,Folic Acid,,,,Alzheimer disease,,,,, -17559847,2525,,causes,,Folic Acid,,,,iron deficiency anemia,,,,, -17044072,2526,,causes,,Folic Acid,,,,depressive disorder,,,,, -15826434,2527,,causes,,Folic Acid,,,,male infertility,,,,, -15057448,2528,,causes,,Folic Acid,,,,chronic kidney disease,,,,, -14954987,2529,,causes,,Folic Acid,,,,autism spectrum disorder,,,,, -13825749,2530,,causes,,Folic Acid,,,,cleft lip,,,,, -13656973,2531,,causes,,Folic Acid,,,,neoplasm,,,,, -12212539,2532,,causes,,Folic Acid,,,,lymphoma,,,,, -11472417,2533,,causes,,Folic Acid,,,,gingival overgrowth,,,,, -11073752,2534,,causes,,Folic Acid,,,,myocardial ischemia,,,,, -10016854,2535,,causes,,Folic Acid,,,,hypertensive disorder,,,,, -8671948,2536,,causes,,Folic Acid,,,,cleft palate,,,,, -8640403,2537,,causes,,Folic Acid,,,,epilepsy,,,,, -7900734,2538,,causes,,Folic Acid,,,,coronary artery disorder,,,,, -7900729,2539,,causes,,Folic Acid,,,,atherosclerosis,,,,, -7637475,2540,,causes,,Folic Acid,,,,Reduced blood folate concentration,,,,, -7460069,2541,,causes,,Folic Acid,,,,anemia,,,,, -7392389,2542,,causes,,Folic Acid,,,,neural tube defect,,,,, -27400709,2543,,affects,,Folic Acid,,,,coronary artery disorder,,,,, -27350602,2544,,affects,,Folic Acid,,,,cleft palate,,,,, -26684582,2545,,affects,,Folic Acid,,,,colorectal neoplasm,,,,, -26504524,2546,,affects,,Folic Acid,,,,neoplasm,,,,, -26433324,2547,,affects,,Folic Acid,,,,psychotic disorder,,,,, -25046427,2548,,affects,,Folic Acid,,,,malaria,,,,, -24121807,2549,,affects,,Folic Acid,,,,osteoporosis,,,,, -23769753,2550,,affects,,Folic Acid,,,,anemia,,,,, -22602503,2551,,affects,,Folic Acid,,,,gingival overgrowth,,,,, -21177262,2552,,affects,,Folic Acid,,,,autism spectrum disorder,,,,, -20060781,2553,,affects,,Folic Acid,,,,Hemorrhage,,,,, -19336710,2554,,affects,,Folic Acid,,,,polycystic ovary syndrome,,,,, -19172236,2555,,affects,,Folic Acid,,,,chronic kidney disease,,,,, -19066599,2556,,affects,,Folic Acid,,,,Alzheimer disease,,,,, -15798837,2557,,affects,,Folic Acid,,,,hypertensive disorder,,,,, -15143772,2558,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, -14869410,2559,,affects,,Folic Acid,,,,epilepsy,,,,, -14664528,2560,,affects,,Folic Acid,,,,depressive disorder,,,,, -14002988,2561,,affects,,Folic Acid,,,,depressive disorder,,,,, -13092563,2562,,affects,,Folic Acid,,,,depressive disorder,,,,, -12773835,2563,,affects,,Folic Acid,,,,atherosclerosis,,,,, -11897009,2564,,affects,,Folic Acid,,,,Alzheimer disease,,,,, -10798682,2565,,affects,,Folic Acid,,,,type 2 diabetes mellitus,,,,, -10733114,2566,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, -10375553,2567,,affects,,Folic Acid,,,,neoplasm,,,,, -10355008,2568,,affects,,Folic Acid,,,,anemia,,,,, -8962241,2569,,affects,,Folic Acid,,,,cleft palate,,,,, -8101952,2570,,affects,,Folic Acid,,,,neural tube defect,,,,, -7127212,2571,,affects,,Folic Acid,,,,neural tube defect,,,,, -19290979,2572,,produces,,Folic Acid,,,,neoplasm,,,,, -26301481,2573,,disrupts,,Folic Acid,,,,epilepsy,,,,, -22602502,2574,,disrupts,,Folic Acid,,,,gingival overgrowth,,,,, -21452213,2575,,disrupts,,Folic Acid,,,,cleft palate,,,,, -20711939,2576,,disrupts,,Folic Acid,,,,autism spectrum disorder,,,,, -20091947,2577,,disrupts,,Folic Acid,,,,atherosclerosis,,,,, -18758283,2578,,disrupts,,Folic Acid,,,,malaria,,,,, -18711179,2579,,disrupts,,Folic Acid,,,,hypertensive disorder,,,,, -16597425,2580,,disrupts,,Folic Acid,,,,neoplasm,,,,, -13887579,2581,,disrupts,,Folic Acid,,,,anemia,,,,, -13415357,2582,,disrupts,,Folic Acid,,,,cleft lip,,,,, -12569851,2583,,disrupts,,Folic Acid,,,,HIV infectious disease,,,,, -11807458,2584,,disrupts,,Folic Acid,,,,colorectal neoplasm,,,,, -10170875,2585,,disrupts,,Folic Acid,,,,depressive disorder,,,,, -8333532,2586,,disrupts,,Folic Acid,,,,neural tube defect,,,,, -8088152,2587,,disrupts,,Folic Acid,,,,Reduced blood folate concentration,,,,, -7255352,2588,,disrupts,,Folic Acid,,,,coronary artery disorder,,,,, -24827653,2589,,prevents,,Folic Acid,,,,Hemorrhage,,,,, -19249670,2590,,prevents,,Folic Acid,,,,epilepsy,,,,, -18676969,2591,,prevents,,Folic Acid,,,,neoplasm,,,,, -17577921,2592,,prevents,,Folic Acid,,,,diabetic kidney disease,,,,, -16233198,2593,,prevents,,Folic Acid,,,,iron deficiency anemia,,,,, -15458838,2594,,prevents,,Folic Acid,,,,myocardial ischemia,,,,, -15385859,2595,,prevents,,Folic Acid,,,,depressive disorder,,,,, -13602735,2596,,prevents,,Folic Acid,,,,gingival overgrowth,,,,, -12999215,2597,,prevents,,Folic Acid,,,,hypertensive disorder,,,,, -12947495,2598,,prevents,,Folic Acid,,,,cleft lip,,,,, -12911127,2599,,prevents,,Folic Acid,,,,Alzheimer disease,,,,, -11842763,2600,,prevents,,Folic Acid,,,,cervical polyp,,,,, -10283354,2601,,prevents,,Folic Acid,,,,heart disorder,,,,, -10242010,2602,,prevents,,Folic Acid,,,,cleft palate,,,,, -9547944,2603,,prevents,,Folic Acid,,,,atherosclerosis,,,,, -9000016,2604,,prevents,,Folic Acid,,,,anemia,,,,, -8746975,2605,,prevents,,Folic Acid,,,,Reduced blood folate concentration,,,,, -8675157,2606,,prevents,,Folic Acid,,,,coronary artery disorder,,,,, -8467407,2607,,prevents,,Folic Acid,,,,myocardial infarction,,,,, -7303516,2608,,prevents,,Folic Acid,,,,neural tube defect,,,,, -23795062,2609,,predisposes,,Folic Acid,,,,depressive disorder,,,,, -20875914,2610,,predisposes,,Folic Acid,,,,chronic kidney disease,,,,, -20436878,2611,,predisposes,,Folic Acid,,,,psychotic disorder,,,,, -19071958,2612,,predisposes,,Folic Acid,,,,type 1 diabetes mellitus,,,,, -18723777,2613,,predisposes,,Folic Acid,,,,systemic lupus erythematosus,,,,, -16571781,2614,,predisposes,,Folic Acid,,,,habitual spontaneous abortion,,,,, -16186991,2615,,predisposes,,Folic Acid,,,,Reduced blood folate concentration,,,,, -15780148,2616,,predisposes,,Folic Acid,,,,epilepsy,,,,, -15351663,2617,,predisposes,,Folic Acid,,,,breast neoplasm,,,,, -14681570,2618,,predisposes,,Folic Acid,,,,malaria,,,,, -13204073,2619,,predisposes,,Folic Acid,,,,autism spectrum disorder,,,,, -12966788,2620,,predisposes,,Folic Acid,,,,cleft palate,,,,, -12851634,2621,,predisposes,,Folic Acid,,,,osteoporosis,,,,, -12628867,2622,,predisposes,,Folic Acid,,,,neoplasm,,,,, -11373442,2623,,predisposes,,Folic Acid,,,,colorectal neoplasm,,,,, -11241979,2624,,predisposes,,Folic Acid,,,,hypertensive disorder,,,,, -9419598,2625,,predisposes,,Folic Acid,,,,Alzheimer disease,,,,, -9024956,2626,,predisposes,,Folic Acid,,,,non-small cell lung carcinoma,,,,, -8876702,2627,,predisposes,,Folic Acid,,,,atherosclerosis,,,,, -8590186,2628,,predisposes,,Folic Acid,,,,anemia,,,,, -8210149,2629,,predisposes,,Folic Acid,,,,myocardial ischemia,,,,, -8202566,2630,,predisposes,,Folic Acid,,,,coronary artery disorder,,,,, -7807562,2631,,predisposes,,Folic Acid,,,,myocardial infarction,,,,, -7720012,2632,,subclass of,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -26246718,2633,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -25613560,2634,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -20340997,2635,,physically interacts with,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -26417219,2636,,physically interacts with,,Phenylbutazone,,,,"1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",,,,, -17467114,2637,,affects,,Phenylbutazone,,,,rheumatic disorder,,,,, -8146434,2638,,affects,,Phenylbutazone,,,,Oxyphenbutazone,,,,, -7720012,2639,,subclass of,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -25613560,2640,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -26246718,2641,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -20340997,2642,,physically interacts with,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -8146434,2643,,affects,,Oxyphenbutazone,,,,Phenylbutazone,,,,, -19336632,2644,,prevents,,Etofenamate,,,,Arthralgia,,,,, -11418550,2645,,subclass of,,Piroxicam,,,,5'-Hydroxypiroxicam,,,,, -27695181,2646,,affects,,Piroxicam,,,,osteoarthritis,,,,, -24435495,2647,,affects,,Piroxicam,,,,Pain,,,,, -18791248,2648,,disrupts,,Piroxicam,,,,Pain,,,,, -13746683,2649,,prevents,,Piroxicam,,,,Myalgia,,,,, -13092622,2650,,prevents,,Piroxicam,,,,Pain,,,,, -9050885,2651,,related to,,Bufexamac,,,,rheumatic disorder,,,,, -27600921,2652,,related to,,Mometasone furoate,,,,psoriasis,,,,, -26936147,2653,,related to,,Mometasone furoate,,,,skin disorder,,,,, -20328277,2654,,related to,,Mometasone furoate,,,,obstructive sleep apnea syndrome,,,,, -20031657,2655,,related to,,Mometasone furoate,,,,diffuse alopecia areata,,,,, -18451558,2656,,related to,,Mometasone furoate,,,,spinal cord injury,,,,, -15193244,2657,,related to,,Mometasone furoate,,,,severe acute respiratory syndrome,,,,, -12129006,2658,,related to,,Mometasone furoate,,,,asthma,,,,, -12122099,2659,,related to,,Mometasone furoate,,,,allergic rhinitis,,,,, -11696210,2660,,related to,,Mometasone furoate,,,,chronic obstructive pulmonary disease,,,,, -10078337,2661,,related to,,Mometasone furoate,,,,perennial allergic rhinitis,,,,, -8366912,2662,,related to,,Mometasone furoate,,,,seasonal allergic rhinitis,,,,, -15620377,2663,,affects,,Mometasone furoate,,,,asthma,,,,, -14474022,2664,,affects,,Mometasone furoate,,,,Nasal congestion,,,,, -8375063,2665,,affects,,Mometasone furoate,,,,allergic rhinitis,,,,, -17026384,2666,,prevents,,Mometasone furoate,,,,Nasal congestion,,,,, -15945486,2667,,prevents,,Mometasone furoate,,,,nasal cavity polyp,,,,, -10581126,2668,,related to,,Methimazole,,,,hyperthyroidism,,,,, -8213703,2669,,causes,,Methimazole,,,,hyperthyroidism,,,,, -10543639,2670,,affects,,Methimazole,,,,hyperthyroidism,,,,, -25010771,2671,,prevents,,Methimazole,,,,hyperthyroidism,,,,, -24946616,2672,,physically interacts with,,Safinamide,,,,Monoamine Oxidase B,,,,, -19231919,2673,,affects,,Safinamide,,,,Parkinson disease,,,,, -13464423,2674,,affects,,Safinamide,,,,Monoamine Oxidase B,,,,, -25942595,2675,,related to,,Furosemide,,,,nephrotic syndrome,,,,, -25824332,2676,,related to,,Furosemide,,,,Fibrosis,,,,, -25791999,2677,,related to,,Furosemide,,,,cirrhosis of liver,,,,, -25414865,2678,,related to,,Furosemide,,,,syndromic disease,,,,, -24461287,2679,,related to,,Furosemide,,,,essential hypertension,,,,, -22834232,2680,,related to,,Furosemide,,,,type 2 diabetes mellitus,,,,, -19148228,2681,,related to,,Furosemide,,,,hypertensive disorder,,,,, -13031496,2682,,related to,,Furosemide,,,,acute kidney failure,,,,, -8084093,2683,,related to,,Furosemide,,,,kidney failure,,,,, -27482853,2684,,causes,,Furosemide,,,,Edema,,,,, -27015887,2685,,causes,,Furosemide,,,,diabetes mellitus,,,,, -25990601,2686,,causes,,Furosemide,,,,hypertensive disorder,,,,, -25918508,2687,,causes,,Furosemide,,,,kidney disorder,,,,, -20167150,2688,,causes,,Furosemide,,,,syndromic disease,,,,, -19659078,2689,,causes,,Furosemide,,,,kidney failure,,,,, -11605290,2690,,causes,,Furosemide,,,,nephrotic syndrome,,,,, -9601857,2691,,causes,,Furosemide,,,,acute kidney failure,,,,, -8252635,2692,,causes,,Furosemide,,,,Dyspnea,,,,, -26185017,2693,,affects,,Furosemide,,,,myocardial infarction,,,,, -25909260,2694,,affects,,Furosemide,,,,nephrotic syndrome,,,,, -22504977,2695,,affects,,Furosemide,,,,cirrhosis of liver,,,,, -17729926,2696,,affects,,Furosemide,,,,Edema,,,,, -16155102,2697,,affects,,Furosemide,,,,kidney disorder,,,,, -15732141,2698,,affects,,Furosemide,,,,hypertensive disorder,,,,, -14935630,2699,,affects,,Furosemide,,,,kidney failure,,,,, -14887041,2700,,affects,,Furosemide,,,,acute kidney failure,,,,, -14148250,2701,,affects,,Furosemide,,,,kidney failure,,,,, -13740455,2702,,affects,,Furosemide,,,,Dyspnea,,,,, -12836864,2703,,affects,,Furosemide,,,,Edema,,,,, -10718312,2704,,affects,,Furosemide,,,,diabetes mellitus,,,,, -8299615,2705,,affects,,Furosemide,,,,acute kidney failure,,,,, -27482854,2706,,disrupts,,Furosemide,,,,Edema,,,,, -19844878,2707,,disrupts,,Furosemide,,,,Dyspnea,,,,, -24717003,2708,,prevents,,Furosemide,,,,pulmonary edema,,,,, -22953098,2709,,prevents,,Furosemide,,,,Dyspnea,,,,, -21527038,2710,,prevents,,Furosemide,,,,schizophrenia,,,,, -20769925,2711,,prevents,,Furosemide,,,,bronchopulmonary dysplasia,,,,, -12415888,2712,,prevents,,Furosemide,,,,kidney disorder,,,,, -11075685,2713,,prevents,,Furosemide,,,,hypertensive disorder,,,,, -9165205,2714,,prevents,,Furosemide,,,,Edema,,,,, -8733555,2715,,prevents,,Furosemide,,,,syndromic disease,,,,, -7901682,2716,,prevents,,Furosemide,,,,kidney failure,,,,, -24388792,2717,,predisposes,,Furosemide,,,,acute kidney failure,,,,, -23800241,2718,,predisposes,,Furosemide,,,,myocardial infarction,,,,, -21525697,2719,,predisposes,,Furosemide,,,,atherosclerosis,,,,, -16660855,2720,,predisposes,,Furosemide,,,,kidney disorder,,,,, -19565633,2721,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, -14176438,2722,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, -15189827,2723,,affects,,Nabumetone,,,,osteoarthritis,,,,, -9219116,2724,,affects,,Nabumetone,,,,Cyclooxygenase 2,,,,, -11784119,2725,,related to,,Selegiline,,,,Parkinson disease,,,,, -7091710,2726,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, -7091710,2727,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, -26670675,2728,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, -26670675,2729,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, -13016594,2730,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, -26762387,2731,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, -27251718,2732,,causes,,Selegiline,,,,depressive disorder,,,,, -18216942,2733,,causes,,Selegiline,,,,Parkinson disease,,,,, -8842901,2734,,affects,,Selegiline,,,,Parkinson disease,,,,, -7091708,2735,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, -8615177,2736,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, -11022843,2737,,disrupts,,Selegiline,,,,Parkinson disease,,,,, -8202759,2738,,prevents,,Selegiline,,,,depressive disorder,,,,, -7205408,2739,,prevents,,Selegiline,,,,Parkinson disease,,,,, -21543223,2740,,causes,,Bumetanide,,,,pervasive developmental disorder,,,,, -22325231,2741,,affects,,Bumetanide,,,,pervasive developmental disorder,,,,, -20190253,2742,,affects,,Bumetanide,,,,autism spectrum disorder,,,,, -16914848,2743,,prevents,,Bumetanide,,,,autism spectrum disorder,,,,, -11943751,2744,,related to,,D-Glucosamine,,,,breast neoplasm,,,,, -7809202,2745,,related to,,D-Glucosamine,,,,osteoarthritis,,,,, -27619077,2746,,causes,,D-Glucosamine,,,,obesity disorder,,,,, -18633463,2747,,causes,,D-Glucosamine,,,,osteoarthritis,,,,, -9909825,2748,,affects,,D-Glucosamine,,,,osteoarthritis,,,,, -8968754,2749,,affects,,D-Glucosamine,,,,obesity disorder,,,,, -13460623,2750,,disrupts,,D-Glucosamine,,,,osteoarthritis,,,,, -11817662,2751,,prevents,,D-Glucosamine,,,,osteoarthritis,,,,, -25749858,2752,,causes,,Torsemide,,,,hypertensive disorder,,,,, -26478746,2753,,affects,,Torsemide,,,,hypertensive disorder,,,,, -13754465,2754,,affects,,Torsemide,,,,hypertensive disorder,,,,, -24478260,2755,,related to,,Leuprorelin,,,,infertility disorder,,,,, -22375547,2756,,related to,,Leuprorelin,,,,neoplasm,,,,, -17696905,2757,,related to,,Leuprorelin,,,,leiomyoma,,,,, -16368292,2758,,related to,,Leuprorelin,,,,prostate cancer,,,,, -15413679,2759,,related to,,Leuprorelin,,,,endometriosis,,,,, -9878755,2760,,causes,,Leuprorelin,,,,hypogonadism,,,,, -7418968,2761,,causes,,Leuprorelin,,,,neoplasm,,,,, -27571709,2762,,affects,,Leuprorelin,,,,prostate cancer,,,,, -27571708,2763,,affects,,Leuprorelin,,,,endometriosis,,,,, -26547561,2764,,affects,,Leuprorelin,,,,endometriosis,,,,, -26152029,2765,,affects,,Leuprorelin,,,,prostate cancer,,,,, -27542556,2766,,prevents,,Leuprorelin,,,,neoplasm,,,,, -12402472,2767,,prevents,,Leuprorelin,,,,Pain,,,,, -7814590,2768,,subclass of,,Sodium Bicarbonate,,,,Electrolytes,,,,, -26447678,2769,,related to,,Sodium Bicarbonate,,,,cystic fibrosis,,,,, -26270339,2770,,related to,,Sodium Bicarbonate,,,,kidney failure,,,,, -20718850,2771,,related to,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -15047625,2772,,related to,,Sodium Bicarbonate,,,,Pain,,,,, -14688492,2773,,related to,,Sodium Bicarbonate,,,,chronic renal failure syndrome,,,,, -13166244,2774,,related to,,Sodium Bicarbonate,,,,kidney disorder,,,,, -12100581,2775,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, -13772853,2776,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, -27495118,2777,,causes,,Sodium Bicarbonate,,,,kidney failure,,,,, -18327883,2778,,causes,,Sodium Bicarbonate,,,,kidney disorder,,,,, -14549296,2779,,causes,,Sodium Bicarbonate,,,,injury,,,,, -8914995,2780,,causes,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -25712033,2781,,affects,,Sodium Bicarbonate,,,,Abnormality of acid-base homeostasis,,,,, -18411502,2782,,affects,,Sodium Bicarbonate,,,,injury,,,,, -17654743,2783,,affects,,Sodium Bicarbonate,,,,kidney disorder,,,,, -12960490,2784,,affects,,Sodium Bicarbonate,,,,Pain,,,,, -8914994,2785,,affects,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -14651482,2786,,disrupts,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -21103228,2787,,prevents,,Sodium Bicarbonate,,,,acidosis disorder,,,,, -13938650,2788,,prevents,,Sodium Bicarbonate,,,,injury,,,,, -11746267,2789,,prevents,,Sodium Bicarbonate,,,,kidney failure,,,,, -11205688,2790,,prevents,,Sodium Bicarbonate,,,,acute kidney failure,,,,, -11205686,2791,,prevents,,Sodium Bicarbonate,,,,kidney disorder,,,,, -14663272,2792,,predisposes,,Sodium Bicarbonate,,,,kidney disorder,,,,, -14542214,2793,,predisposes,,Sodium Bicarbonate,,,,injury,,,,, -17530350,2794,,affects,,Olmesartan medoxomil,,,,diabetic kidney disease,,,,, -12894557,2795,,affects,,Olmesartan medoxomil,,,,atherosclerosis,,,,, -12254737,2796,,affects,,Olmesartan medoxomil,,,,diabetes mellitus,,,,, -15583038,2797,,disrupts,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, -12254736,2798,,disrupts,,Olmesartan medoxomil,,,,proteinuria,,,,, -12254735,2799,,prevents,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, -9359700,2800,,prevents,,Olmesartan medoxomil,,,,atherosclerosis,,,,, -8752749,2801,,related to,,Candesartan,,,,essential hypertension,,,,, -20752265,2802,,causes,,Candesartan,,,,Cognitive impairment,,,,, -14838058,2803,,causes,,Candesartan,,,,hypertensive disorder,,,,, -20512666,2804,,affects,,Candesartan,,,,Cognitive impairment,,,,, -20051167,2805,,affects,,Candesartan,,,,hypertensive disorder,,,,, -19501045,2806,,affects,,Candesartan,,,,Cognitive impairment,,,,, -14118850,2807,,affects,,Candesartan,,,,Left ventricular hypertrophy,,,,, -9919312,2808,,affects,,Candesartan,,,,hypertensive disorder,,,,, -14542524,2809,,disrupts,,Candesartan,,,,Left ventricular hypertrophy,,,,, -9479295,2810,,disrupts,,Candesartan,,,,hypertensive disorder,,,,, -24756017,2811,,prevents,,Candesartan,,,,Cognitive impairment,,,,, -15502429,2812,,prevents,,Candesartan,,,,cardiovascular disorder,,,,, -12994289,2813,,prevents,,Candesartan,,,,Left ventricular hypertrophy,,,,, -12444324,2814,,prevents,,Candesartan,,,,atrial fibrillation,,,,, -12421723,2815,,prevents,,Candesartan,,,,migraine disorder,,,,, -8787605,2816,,prevents,,Candesartan,,,,hypertensive disorder,,,,, -9420113,2817,,related to,,Telmisartan,,,,diabetes mellitus,,,,, -9420112,2818,,related to,,Telmisartan,,,,hypertensive disorder,,,,, -16669618,2819,,causes,,Telmisartan,,,,cardiovascular disorder,,,,, -16637024,2820,,causes,,Telmisartan,,,,hypertensive disorder,,,,, -16559226,2821,,causes,,Telmisartan,,,,myocardial infarction,,,,, -14418892,2822,,causes,,Telmisartan,,,,Albuminuria,,,,, -13301662,2823,,causes,,Telmisartan,,,,diabetes mellitus,,,,, -20835589,2824,,affects,,Telmisartan,,,,diabetic kidney disease,,,,, -17882285,2825,,affects,,Telmisartan,,,,Albuminuria,,,,, -16266744,2826,,affects,,Telmisartan,,,,Albuminuria,,,,, -15802746,2827,,affects,,Telmisartan,,,,diabetes mellitus,,,,, -13992848,2828,,affects,,Telmisartan,,,,diabetes mellitus,,,,, -13861721,2829,,affects,,Telmisartan,,,,type 2 diabetes mellitus,,,,, -13824093,2830,,affects,,Telmisartan,,,,Albuminuria,,,,, -13501012,2831,,affects,,Telmisartan,,,,essential hypertension,,,,, -13178302,2832,,affects,,Telmisartan,,,,hypertensive disorder,,,,, -25051574,2833,,disrupts,,Telmisartan,,,,Alzheimer disease,,,,, -14418891,2834,,disrupts,,Telmisartan,,,,Albuminuria,,,,, -13325686,2835,,disrupts,,Telmisartan,,,,hypertensive disorder,,,,, -21182197,2836,,prevents,,Telmisartan,,,,Alzheimer disease,,,,, -17513403,2837,,prevents,,Telmisartan,,,,myocardial infarction,,,,, -17170882,2838,,prevents,,Telmisartan,,,,type 2 diabetes mellitus,,,,, -13010398,2839,,prevents,,Telmisartan,,,,stroke disorder,,,,, -12278433,2840,,prevents,,Telmisartan,,,,diabetic kidney disease,,,,, -11585228,2841,,prevents,,Telmisartan,,,,diabetes mellitus,,,,, -11585227,2842,,prevents,,Telmisartan,,,,cardiovascular disorder,,,,, -11473935,2843,,prevents,,Telmisartan,,,,hypertensive disorder,,,,, -17028323,2844,,predisposes,,Telmisartan,,,,stroke disorder,,,,, -17028322,2845,,predisposes,,Telmisartan,,,,myocardial infarction,,,,, -21651336,2846,,causes,,Irbesartan,,,,hypertensive disorder,,,,, -19454247,2847,,affects,,Irbesartan,,,,Sepsis,,,,, -13143483,2848,,affects,,Irbesartan,,,,type 2 diabetes mellitus,,,,, -9015828,2849,,affects,,Irbesartan,,,,chronic kidney disease,,,,, -9015827,2850,,affects,,Irbesartan,,,,diabetic kidney disease,,,,, -7812861,2851,,affects,,Irbesartan,,,,acute kidney failure,,,,, -19016605,2852,,disrupts,,Irbesartan,,,,atrial fibrillation,,,,, -11936096,2853,,disrupts,,Irbesartan,,,,hypertensive disorder,,,,, -9297339,2854,,disrupts,,Irbesartan,,,,diabetic kidney disease,,,,, -11467158,2855,,prevents,,Irbesartan,,,,chronic kidney disease,,,,, -9856662,2856,,prevents,,Irbesartan,,,,diabetic kidney disease,,,,, -8753962,2857,,prevents,,Irbesartan,,,,hypertensive disorder,,,,, -15497727,2858,,predisposes,,Irbesartan,,,,cardiovascular disorder,,,,, -12041301,2859,,predisposes,,Irbesartan,,,,IgA glomerulonephritis,,,,, -9459261,2860,,related to,,Eprosartan,,,,essential hypertension,,,,, -8111433,2861,,related to,,Valsartan,,,,essential hypertension,,,,, -18505936,2862,,causes,,Valsartan,,,,myocardial infarction,,,,, -13301661,2863,,causes,,Valsartan,,,,diabetes mellitus,,,,, -18533693,2864,,affects,,Valsartan,,,,hypertensive disorder,,,,, -18130226,2865,,affects,,Valsartan,,,,stroke disorder,,,,, -16609149,2866,,affects,,Valsartan,,,,kidney disorder,,,,, -9837968,2867,,affects,,Valsartan,,,,Abnormal left ventricular function,,,,, -15479686,2868,,disrupts,,Valsartan,,,,type 2 diabetes mellitus,,,,, -11438135,2869,,disrupts,,Valsartan,,,,atherosclerosis,,,,, -20671333,2870,,prevents,,Valsartan,,,,Abnormal left ventricular function,,,,, -15012324,2871,,prevents,,Valsartan,,,,type 2 diabetes mellitus,,,,, -13899819,2872,,prevents,,Valsartan,,,,stroke disorder,,,,, -12374506,2873,,prevents,,Valsartan,,,,diabetes mellitus,,,,, -12038680,2874,,prevents,,Valsartan,,,,myocardial infarction,,,,, -11801448,2875,,prevents,,Valsartan,,,,atrial fibrillation,,,,, -8617185,2876,,prevents,,Valsartan,,,,coronary artery disorder,,,,, -7691192,2877,,prevents,,Valsartan,,,,hypertensive disorder,,,,, -7604460,2878,,prevents,,Valsartan,,,,atherosclerosis,,,,, -21524148,2879,,predisposes,,Valsartan,,,,myocardial infarction,,,,, -11133518,2880,,predisposes,,Valsartan,,,,cardiovascular disorder,,,,, -13065808,2881,,related to,,Losartan,,,,non-alcoholic fatty liver disease,,,,, -12094342,2882,,related to,,Losartan,,,,proteinuria,,,,, -11472713,2883,,related to,,Losartan,,,,kidney disorder,,,,, -10013644,2884,,related to,,Losartan,,,,hypertensive disorder,,,,, -8975375,2885,,related to,,Losartan,,,,IgA glomerulonephritis,,,,, -16215194,2886,,causes,,Losartan,,,,injury,,,,, -15690681,2887,,causes,,Losartan,,,,kidney disorder,,,,, -9749061,2888,,causes,,Losartan,,,,hypertensive disorder,,,,, -7310301,2889,,causes,,Losartan,,,,proteinuria,,,,, -7204638,2890,,causes,,Losartan,,,,Left ventricular hypertrophy,,,,, -26608778,2891,,affects,,Losartan,,,,essential hypertension,,,,, -24425437,2892,,affects,,Losartan,,,,cystic fibrosis,,,,, -21888728,2893,,affects,,Losartan,,,,proteinuria,,,,, -20488125,2894,,affects,,Losartan,,,,hypertensive disorder,,,,, -19990804,2895,,affects,,Losartan,,,,aortic valve insufficiency,,,,, -18707849,2896,,affects,,Losartan,,,,hypertrophic cardiomyopathy,,,,, -16976701,2897,,affects,,Losartan,,,,IgA glomerulonephritis,,,,, -13986638,2898,,affects,,Losartan,,,,adult acute respiratory distress syndrome,,,,, -13539739,2899,,affects,,Losartan,,,,proteinuria,,,,, -13498248,2900,,affects,,Losartan,,,,Inflammation,,,,, -12531070,2901,,affects,,Losartan,,,,Left ventricular hypertrophy,,,,, -10809955,2902,,affects,,Losartan,,,,hypertensive disorder,,,,, -9615315,2903,,affects,,Losartan,,,,diabetic kidney disease,,,,, -9459571,2904,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, -9229634,2905,,affects,,Losartan,,,,kidney disorder,,,,, -8678480,2906,,affects,,Losartan,,,,injury,,,,, -8551167,2907,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, -18715311,2908,,disrupts,,Losartan,,,,breast neoplasm,,,,, -14458903,2909,,disrupts,,Losartan,,,,pancreatic neoplasm,,,,, -13976332,2910,,disrupts,,Losartan,,,,diabetic kidney disease,,,,, -12949848,2911,,disrupts,,Losartan,,,,Inflammation,,,,, -9870082,2912,,disrupts,,Losartan,,,,hypertensive disorder,,,,, -9655766,2913,,disrupts,,Losartan,,,,type 2 diabetes mellitus,,,,, -8325352,2914,,disrupts,,Losartan,,,,Left ventricular hypertrophy,,,,, -7975855,2915,,disrupts,,Losartan,,,,injury,,,,, -7310299,2916,,disrupts,,Losartan,,,,proteinuria,,,,, -21356716,2917,,prevents,,Losartan,,,,post-traumatic stress disorder,,,,, -14540327,2918,,prevents,,Losartan,,,,kidney disorder,,,,, -12407992,2919,,prevents,,Losartan,,,,Inflammation,,,,, -10030687,2920,,prevents,,Losartan,,,,cardiovascular disorder,,,,, -9856661,2921,,prevents,,Losartan,,,,diabetic kidney disease,,,,, -9773800,2922,,prevents,,Losartan,,,,Left ventricular hypertrophy,,,,, -9766007,2923,,prevents,,Losartan,,,,adult acute respiratory distress syndrome,,,,, -9420091,2924,,prevents,,Losartan,,,,Stenosis,,,,, -9077908,2925,,prevents,,Losartan,,,,proteinuria,,,,, -8542944,2926,,prevents,,Losartan,,,,injury,,,,, -7768196,2927,,prevents,,Losartan,,,,hypertensive disorder,,,,, -14272023,2928,,predisposes,,Losartan,,,,kidney disorder,,,,, -12616336,2929,,predisposes,,Losartan,,,,cardiovascular disorder,,,,, -9964252,2930,,predisposes,,Losartan,,,,Left ventricular hypertrophy,,,,, -20586471,2931,,related to,,Dronabinol,,,,multiple sclerosis,,,,, -25459397,2932,,causes,,Dronabinol,,,,cannabis dependence,,,,, -22027243,2933,,causes,,Dronabinol,,,,Nausea,,,,, -17252204,2934,,causes,,Dronabinol,,,,schizophrenia,,,,, -12205989,2935,,causes,,Dronabinol,,,,Cognitive impairment,,,,, -27448088,2936,,affects,,Dronabinol,,,,Anorexia,,,,, -25890458,2937,,affects,,Dronabinol,,,,Nausea,,,,, -21879717,2938,,affects,,Dronabinol,,,,anorexia nervosa,,,,, -20855895,2939,,affects,,Dronabinol,,,,neoplasm,,,,, -19991701,2940,,affects,,Dronabinol,,,,obstructive sleep apnea syndrome,,,,, -19474044,2941,,affects,,Dronabinol,,,,multiple sclerosis,,,,, -16547908,2942,,affects,,Dronabinol,,,,schizophrenia,,,,, -14443952,2943,,affects,,Dronabinol,,,,opiate dependence,,,,, -13958866,2944,,affects,,Dronabinol,,,,Cognitive impairment,,,,, -13933776,2945,,affects,,Dronabinol,,,,schizophrenia,,,,, -11304843,2946,,affects,,Dronabinol,,,,neuralgia,,,,, -11058493,2947,,affects,,Dronabinol,,,,Pain,,,,, -24013541,2948,,disrupts,,Dronabinol,,,,Pain,,,,, -17477155,2949,,disrupts,,Dronabinol,,,,HIV infectious disease,,,,, -11615857,2950,,disrupts,,Dronabinol,,,,Nausea,,,,, -25196408,2951,,prevents,,Dronabinol,,,,dementia,,,,, -25026370,2952,,prevents,,Dronabinol,,,,neuralgia,,,,, -18579580,2953,,prevents,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, -18554637,2954,,prevents,,Dronabinol,,,,Nausea,,,,, -17477149,2955,,prevents,,Dronabinol,,,,HIV infectious disease,,,,, -9671016,2956,,prevents,,Dronabinol,,,,Pain,,,,, -22976957,2957,,predisposes,,Dronabinol,,,,Cognitive impairment,,,,, -18579581,2958,,predisposes,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, -26722658,2959,,affects,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, -26699974,2960,,affects,,Cesamet,,,,Nausea,,,,, -19460580,2961,,prevents,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, -25552574,2962,,related to,,Aprepitant,,,,glioblastoma,,,,, -18054447,2963,,related to,,Aprepitant,,,,Vomiting,,,,, -18054446,2964,,related to,,Aprepitant,,,,Nausea,,,,, -11788538,2965,,causes,,Aprepitant,,,,Vomiting,,,,, -11788537,2966,,causes,,Aprepitant,,,,Nausea,,,,, -23692862,2967,,affects,,Aprepitant,,,,Nausea,,,,, -19750085,2968,,affects,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, -17874842,2969,,affects,,Aprepitant,,,,Vomiting,,,,, -12562288,2970,,affects,,Aprepitant,,,,Nausea,,,,, -11119543,2971,,affects,,Aprepitant,,,,Vomiting,,,,, -19013645,2972,,disrupts,,Aprepitant,,,,HIV infectious disease,,,,, -16125731,2973,,disrupts,,Aprepitant,,,,Vomiting,,,,, -16125730,2974,,disrupts,,Aprepitant,,,,Nausea,,,,, -16513148,2975,,prevents,,Aprepitant,,,,Pruritus,,,,, -15868137,2976,,prevents,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, -10160541,2977,,prevents,,Aprepitant,,,,Vomiting,,,,, -10160540,2978,,prevents,,Aprepitant,,,,Nausea,,,,, -20804596,2979,,predisposes,,Aprepitant,,,,Nausea,,,,, -22122089,2980,,affects,,Neratinib,,,,neoplasm,,,,, -21597229,2981,,related to,,Lapatinib,,,,neoplasm,,,,, -13650844,2982,,related to,,Lapatinib,,,,non-small cell lung carcinoma,,,,, -18268107,2983,,affects,,Lapatinib,,,,neoplasm,,,,, -15442238,2984,,affects,,Lapatinib,,,,breast neoplasm,,,,, -14691634,2985,,affects,,Lapatinib,,,,neoplasm,,,,, -17546445,2986,,disrupts,,Lapatinib,,,,neoplasm,,,,, -19410918,2987,,prevents,,Lapatinib,,,,breast neoplasm,,,,, -19317295,2988,,prevents,,Lapatinib,,,,neoplasm,,,,, -16643911,2989,,predisposes,,Lapatinib,,,,neoplasm,,,,, -24360220,2990,,related to,,Nifurtimox,,,,human African trypanosomiasis,,,,, -25977066,2991,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, -25977066,2992,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, -25822629,2993,,causes,,Nifurtimox,,,,Chagas disease,,,,, -21140520,2994,,affects,,Nifurtimox,,,,neuroblastoma,,,,, -19390598,2995,,affects,,Nifurtimox,,,,trypanosomiasis,,,,, -18236131,2996,,affects,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, -21140519,2997,,disrupts,,Nifurtimox,,,,neuroblastoma,,,,, -16729888,2998,,prevents,,Nifurtimox,,,,Chagas disease,,,,, -8359719,2999,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -8359719,3000,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -21506050,3001,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -16350865,3002,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, -26982963,3003,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, -14891197,3004,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, -13216168,3005,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, -9844335,3006,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, -11447618,3007,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, -11253841,3008,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, -8806634,3009,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, -26997768,3010,,affects,,Metopimazine,,,,Nausea,,,,, -12265728,3011,,prevents,,Metopimazine,,,,Nausea,,,,, -27200379,3012,,related to,,Lincomycin,,,,osteomyelitis,,,,, -9905527,3013,,causes,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -9905522,3014,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -8547552,3015,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -11060423,3016,,prevents,,Sulindac,,,,classic familial adenomatous polyposis,,,,, -20876966,3017,,related to,,Ketorolac,,,,migraine disorder,,,,, -27688883,3018,,causes,,Ketorolac,,,,Inflammation,,,,, -21368479,3019,,causes,,Ketorolac,,,,pancreatitis,,,,, -19597016,3020,,causes,,Ketorolac,,,,Miosis,,,,, -12090892,3021,,causes,,Ketorolac,,,,Pain,,,,, -20018980,3022,,affects,,Ketorolac,,,,breast neoplasm,,,,, -19245410,3023,,affects,,Ketorolac,,,,Miosis,,,,, -9719257,3024,,affects,,Ketorolac,,,,Pain,,,,, -24071071,3025,,disrupts,,Ketorolac,,,,Headache,,,,, -24029444,3026,,disrupts,,Ketorolac,,,,Inflammation,,,,, -11549492,3027,,disrupts,,Ketorolac,,,,Pain,,,,, -11362008,3028,,disrupts,,Ketorolac,,,,Back pain,,,,, -24306825,3029,,prevents,,Ketorolac,,,,Renal Colic,,,,, -23612322,3030,,prevents,,Ketorolac,,,,Chronic pain,,,,, -20717559,3031,,prevents,,Ketorolac,,,,injury,,,,, -11362007,3032,,prevents,,Ketorolac,,,,Back pain,,,,, -11361661,3033,,prevents,,Ketorolac,,,,Inflammation,,,,, -11043378,3034,,prevents,,Ketorolac,,,,Headache,,,,, -7985904,3035,,prevents,,Ketorolac,,,,Pain,,,,, -20028754,3036,,predisposes,,Ketorolac,,,,injury,,,,, -25929768,3037,,related to,,Sulfadiazine,,,,congenital toxoplasmosis,,,,, -16546748,3038,,related to,,Sulfadiazine,,,,chorioretinitis,,,,, -27660461,3039,,causes,,Sulfamethoxazole,,,,pneumonia,,,,, -24328685,3040,,causes,,Sulfamethoxazole,,,,kidney disorder,,,,, -14835537,3041,,affects,,Sulfamethoxazole,,,,cystic fibrosis,,,,, -12226918,3042,,affects,,Sulfamethoxazole,,,,ocular toxoplasmosis,,,,, -26634163,3043,,prevents,,Sulfamethoxazole,,,,bacterial infectious disease,,,,, -23781290,3044,,prevents,,Sulfamethoxazole,,,,Infection,,,,, -22185408,3045,,prevents,,Sulfamethoxazole,,,,pneumocystosis,,,,, -21716989,3046,,affects,,Glycyrrhizic acid,,,,osteoarthritis,,,,, -21716987,3047,,disrupts,,Glycyrrhizic acid,,,,osteoarthritis,,,,, -13246285,3048,,related to,,Ciclesonide,,,,perennial allergic rhinitis,,,,, -13246284,3049,,related to,,Ciclesonide,,,,seasonal allergic rhinitis,,,,, -10789097,3050,,related to,,Ciclesonide,,,,asthma,,,,, -13334776,3051,,causes,,Ciclesonide,,,,asthma,,,,, -13603690,3052,,affects,,Ciclesonide,,,,asthma,,,,, -26135729,3053,,related to,,Flunisolide,,,,perennial allergic rhinitis,,,,, -16438918,3054,,related to,,Flunisolide,,,,rhinitis,,,,, -7778368,3055,,related to,,Flunisolide,,,,asthma,,,,, -12189287,3056,,prevents,,Flunisolide,,,,Nasal congestion,,,,, -27725383,3057,,related to,,Etoposide,,,,hepatoblastoma,,,,, -27360363,3058,,related to,,Etoposide,,,,ependymoma,,,,, -27062931,3059,,related to,,Etoposide,,,,supratentorial primitive neuroectodermal tumor,,,,, -26965210,3060,,related to,,Etoposide,,,,kidney Wilms tumor,,,,, -26632944,3061,,related to,,Etoposide,,,,HIV infectious disease,,,,, -22727077,3062,,related to,,Etoposide,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, -21142004,3063,,related to,,Etoposide,,,,AIDS,,,,, -20988037,3064,,related to,,Etoposide,,,,retinoblastoma,,,,, -20394132,3065,,related to,,Etoposide,,,,B-cell neoplasm,,,,, -19900770,3066,,related to,,Etoposide,,,,myelodysplastic syndrome,,,,, -18768176,3067,,related to,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, -17380085,3068,,related to,,Etoposide,,,,Kaposi's sarcoma,,,,, -17284305,3069,,related to,,Etoposide,,,,bone osteosarcoma,,,,, -17191209,3070,,related to,,Etoposide,,,,hepatocellular carcinoma,,,,, -17136035,3071,,related to,,Etoposide,,,,diffuse large B-cell lymphoma,,,,, -16406847,3072,,related to,,Etoposide,,,,neuroendocrine carcinoma,,,,, -16067960,3073,,related to,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, -15501025,3074,,related to,,Etoposide,,,,brain cancer,,,,, -15141728,3075,,related to,,Etoposide,,,,testicular cancer,,,,, -15031494,3076,,related to,,Etoposide,,,,lymphoid leukemia,,,,, -14511230,3077,,related to,,Etoposide,,,,glioblastoma,,,,, -14453465,3078,,related to,,Etoposide,,,,T-cell non-Hodgkin lymphoma,,,,, -13764189,3079,,related to,,Etoposide,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, -12298091,3080,,related to,,Etoposide,,,,breast neoplasm,,,,, -11028194,3081,,related to,,Etoposide,,,,acute lymphoblastic leukemia,,,,, -10672040,3082,,related to,,Etoposide,,,,Ewing sarcoma,,,,, -10503115,3083,,related to,,Etoposide,,,,kidney cancer,,,,, -10441577,3084,,related to,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, -10410657,3085,,related to,,Etoposide,,,,neutropenia,,,,, -10182075,3086,,related to,,Etoposide,,,,non-Hodgkin lymphoma,,,,, -10161953,3087,,related to,,Etoposide,,,,squamous cell carcinoma,,,,, -9231982,3088,,related to,,Etoposide,,,,carcinoma,,,,, -9157972,3089,,related to,,Etoposide,,,,thymoma,,,,, -9138703,3090,,related to,,Etoposide,,,,ovarian cancer,,,,, -9115115,3091,,related to,,Etoposide,,,,sarcoma,,,,, -9024985,3092,,related to,,Etoposide,,,,leukemia,,,,, -9008448,3093,,related to,,Etoposide,,,,Hodgkins lymphoma,,,,, -9006645,3094,,related to,,Etoposide,,,,neuroblastoma,,,,, -8074798,3095,,related to,,Etoposide,,,,medulloblastoma,,,,, -8048523,3096,,related to,,Etoposide,,,,lymphoma,,,,, -7998504,3097,,related to,,Etoposide,,,,plasma cell myeloma,,,,, -7989979,3098,,related to,,Etoposide,,,,neoplasm,,,,, -7896801,3099,,related to,,Etoposide,,,,adult T-cell leukemia/lymphoma,,,,, -7845509,3100,,related to,,Etoposide,,,,glioma,,,,, -7810052,3101,,related to,,Etoposide,,,,castration-resistant prostate carcinoma,,,,, -7711547,3102,,related to,,Etoposide,,,,acute myeloid leukemia,,,,, -7319060,3103,,related to,,Etoposide,,,,small cell lung carcinoma,,,,, -7200681,3104,,related to,,Etoposide,,,,non-small cell lung carcinoma,,,,, -23328204,3105,,causes,,Etoposide,,,,small cell lung carcinoma,,,,, -12215704,3106,,causes,,Etoposide,,,,neoplasm,,,,, -8706370,3107,,causes,,Etoposide,,,,neutropenia,,,,, -7869845,3108,,causes,,Etoposide,,,,leukemia,,,,, -7642766,3109,,causes,,Etoposide,,,,acute myeloid leukemia,,,,, -27374335,3110,,affects,,Etoposide,,,,retinoblastoma,,,,, -26960810,3111,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, -25269562,3112,,affects,,Etoposide,,,,hemophagocytic syndrome,,,,, -23238600,3113,,affects,,Etoposide,,,,choriocarcinoma,,,,, -18166706,3114,,affects,,Etoposide,,,,neuroblastoma,,,,, -17967080,3115,,affects,,Etoposide,,,,leukemia,,,,, -17160632,3116,,affects,,Etoposide,,,,carcinoma,,,,, -16724406,3117,,affects,,Etoposide,,,,neoplasm,,,,, -16425822,3118,,affects,,Etoposide,,,,leukemia,,,,, -15965763,3119,,affects,,Etoposide,,,,testicular cancer,,,,, -12798395,3120,,affects,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, -11699750,3121,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, -11396769,3122,,affects,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, -9913818,3123,,affects,,Etoposide,,,,acute erythroid leukemia,,,,, -9397866,3124,,affects,,Etoposide,,,,fallopian tube neoplasm,,,,, -9293530,3125,,affects,,Etoposide,,,,carcinoid tumor,,,,, -8200378,3126,,affects,,Etoposide,,,,neoplasm,,,,, -8003315,3127,,affects,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, -7908520,3128,,affects,,Etoposide,,,,B-cell neoplasm,,,,, -24115005,3129,,disrupts,,Etoposide,,,,small cell lung carcinoma,,,,, -17149618,3130,,disrupts,,Etoposide,,,,hemophagocytic syndrome,,,,, -16511954,3131,,disrupts,,Etoposide,,,,glioblastoma,,,,, -16039903,3132,,disrupts,,Etoposide,,,,neoplasm,,,,, -14383828,3133,,disrupts,,Etoposide,,,,bone osteosarcoma,,,,, -9134229,3134,,prevents,,Etoposide,,,,neoplasm,,,,, -22634859,3135,,predisposes,,Etoposide,,,,neoplasm,,,,, -18673787,3136,,predisposes,,Etoposide,,,,brain cancer,,,,, -16345738,3137,,predisposes,,Etoposide,,,,myelodysplastic syndrome,,,,, -16345737,3138,,predisposes,,Etoposide,,,,acute myeloid leukemia,,,,, -10333072,3139,,predisposes,,Etoposide,,,,leukemia,,,,, -16677028,3140,,related to,,Teniposide,,,,neoplasm,,,,, -10688707,3141,,related to,,Teniposide,,,,lymphoma,,,,, -10688706,3142,,related to,,Teniposide,,,,leukemia,,,,, -27095076,3143,,affects,,Teniposide,,,,leukemia,,,,, -26849066,3144,,predisposes,,Teniposide,,,,leukemia,,,,, -18768362,3145,,related to,,Urofollitropin,,,,hypogonadism,,,,, -18095820,3146,,related to,,Urofollitropin,,,,primary ovarian failure,,,,, -9960851,3147,,related to,,Urofollitropin,,,,anovulation,,,,, -9716197,3148,,related to,,Urofollitropin,,,,female infertility,,,,, -8496709,3149,,related to,,Urofollitropin,,,,infertility disorder,,,,, -8454088,3150,,related to,,Urofollitropin,,,,male infertility,,,,, -8378642,3151,,related to,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -8205307,3152,,related to,,Urofollitropin,,,,azoospermia,,,,, -14878529,3153,,related to,,Urofollitropin,,,,female infertility,,,,, -9422493,3154,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -9422493,3155,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -10444908,3156,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -10444908,3157,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7103614,3158,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7103614,3159,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7302412,3160,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -7606444,3161,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -21372974,3162,,causes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -16723493,3163,,causes,,Urofollitropin,,,,hypogonadism,,,,, -16322495,3164,,causes,,Urofollitropin,,,,azoospermia,,,,, -9453052,3165,,causes,,Urofollitropin,,,,primary ovarian failure,,,,, -8923757,3166,,causes,,Urofollitropin,,,,Pregnancy,,,,, -8815215,3167,,causes,,Urofollitropin,,,,anovulation,,,,, -8590972,3168,,causes,,Urofollitropin,,,,male infertility,,,,, -8270576,3169,,causes,,Urofollitropin,,,,infertility disorder,,,,, -19357829,3170,,affects,,Urofollitropin,,,,gonadal disorder,,,,, -15865492,3171,,affects,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -14984090,3172,,affects,,Urofollitropin,,,,male infertility,,,,, -13249247,3173,,affects,,Urofollitropin,,,,Pregnancy,,,,, -10980447,3174,,affects,,Urofollitropin,,,,Pregnancy,,,,, -8590971,3175,,affects,,Urofollitropin,,,,male infertility,,,,, -7302415,3176,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -9844029,3177,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -27587327,3178,,produces,,Urofollitropin,,,,primary ovarian failure,,,,, -20465917,3179,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -20465917,3180,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, -8502213,3181,,produces,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -20569186,3182,,disrupts,,Urofollitropin,,,,Pregnancy,,,,, -11195885,3183,,prevents,,Urofollitropin,,,,azoospermia,,,,, -17502146,3184,,predisposes,,Urofollitropin,,,,azoospermia,,,,, -16417247,3185,,predisposes,,Urofollitropin,,,,anovulation,,,,, -16278695,3186,,predisposes,,Urofollitropin,,,,infertility disorder,,,,, -15110465,3187,,predisposes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, -7379891,3188,,predisposes,,Urofollitropin,,,,primary ovarian failure,,,,, -23895216,3189,,affects,,Ivacaftor,,,,cystic fibrosis,,,,, -20354463,3190,,related to,,Nitric oxide,,,,ST-elevation myocardial infarction,,,,, -17273075,3191,,related to,,Nitric oxide,,,,bronchiolitis,,,,, -15880296,3192,,related to,,Nitric oxide,,,,Diabetic Foot,,,,, -14910010,3193,,related to,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, -14573099,3194,,related to,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, -11752178,3195,,related to,,Nitric oxide,,,,cutaneous leishmaniasis,,,,, -9816415,3196,,related to,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, -9774015,3197,,related to,,Nitric oxide,,,,respiratory system disorder,,,,, -8707490,3198,,related to,,Nitric oxide,,,,myocardial infarction,,,,, -8593326,3199,,related to,,Nitric oxide,,,,neuralgia,,,,, -8476870,3200,,related to,,Nitric oxide,,,,lung disorder,,,,, -8350800,3201,,related to,,Nitric oxide,,,,opiate dependence,,,,, -8343542,3202,,related to,,Nitric oxide,,,,Varicose Ulcer,,,,, -8057943,3203,,related to,,Nitric oxide,,,,malaria,,,,, -8040944,3204,,related to,,Nitric oxide,,,,sickle cell anemia,,,,, -7963930,3205,,related to,,Nitric oxide,,,,cystic fibrosis,,,,, -7923041,3206,,related to,,Nitric oxide,,,,brain injury,,,,, -7788094,3207,,related to,,Nitric oxide,,,,myocardial ischemia,,,,, -7738003,3208,,related to,,Nitric oxide,,,,Hypoxemia,,,,, -7725812,3209,,related to,,Nitric oxide,,,,Premature birth,,,,, -7657450,3210,,related to,,Nitric oxide,,,,pulmonary embolism,,,,, -7539810,3211,,related to,,Nitric oxide,,,,stroke disorder,,,,, -7481315,3212,,related to,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -7449413,3213,,related to,,Nitric oxide,,,,respiratory failure,,,,, -7439172,3214,,related to,,Nitric oxide,,,,neoplasm,,,,, -7418030,3215,,related to,,Nitric oxide,,,,acute kidney failure,,,,, -7373096,3216,,related to,,Nitric oxide,,,,brain ischemia,,,,, -7345317,3217,,related to,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, -7242606,3218,,related to,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -7159413,3219,,related to,,Nitric oxide,,,,Sepsis,,,,, -7145311,3220,,related to,,Nitric oxide,,,,Inflammation,,,,, -7091337,3221,,related to,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -14184908,3222,,related to,,Nitric oxide,,,,Inflammation,,,,, -27698007,3223,,causes,,Nitric oxide,,,,lung disorder,,,,, -23636922,3224,,causes,,Nitric oxide,,,,Infection,,,,, -22013082,3225,,causes,,Nitric oxide,,,,sickle cell anemia,,,,, -21447838,3226,,causes,,Nitric oxide,,,,respiratory system disorder,,,,, -14028136,3227,,causes,,Nitric oxide,,,,stroke disorder,,,,, -12046903,3228,,causes,,Nitric oxide,,,,cystic fibrosis,,,,, -11887505,3229,,causes,,Nitric oxide,,,,myocardial ischemia,,,,, -11842330,3230,,causes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -11556568,3231,,causes,,Nitric oxide,,,,acute kidney failure,,,,, -11353052,3232,,causes,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -9962165,3233,,causes,,Nitric oxide,,,,malaria,,,,, -9795722,3234,,causes,,Nitric oxide,,,,neuralgia,,,,, -9068211,3235,,causes,,Nitric oxide,,,,pneumonia,,,,, -8934561,3236,,causes,,Nitric oxide,,,,brain injury,,,,, -8855613,3237,,causes,,Nitric oxide,,,,neoplasm,,,,, -8834736,3238,,causes,,Nitric oxide,,,,myocardial infarction,,,,, -8346309,3239,,causes,,Nitric oxide,,,,Premature birth,,,,, -8185371,3240,,causes,,Nitric oxide,,,,Inflammation,,,,, -8037779,3241,,causes,,Nitric oxide,,,,brain ischemia,,,,, -7409857,3242,,causes,,Nitric oxide,,,,Sepsis,,,,, -7184490,3243,,causes,,Nitric oxide,,,,Hypoxemia,,,,, -27626134,3244,,affects,,Nitric oxide,,,,cystic fibrosis,,,,, -27208311,3245,,affects,,Nitric oxide,,,,opiate dependence,,,,, -27058878,3246,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, -20413999,3247,,affects,,Nitric oxide,,,,brain injury,,,,, -19764415,3248,,affects,,Nitric oxide,,,,pneumonia,,,,, -18632674,3249,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, -17798838,3250,,affects,,Nitric oxide,,,,neuralgia,,,,, -17030125,3251,,affects,,Nitric oxide,,,,bronchiolitis,,,,, -12566083,3252,,affects,,Nitric oxide,,,,respiratory system disorder,,,,, -11778681,3253,,affects,,Nitric oxide,,,,stroke disorder,,,,, -11521495,3254,,affects,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, -11353389,3255,,affects,,Nitric oxide,,,,myocardial infarction,,,,, -10403969,3256,,affects,,Nitric oxide,,,,anemia,,,,, -10222313,3257,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -10099288,3258,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, -10018002,3259,,affects,,Nitric oxide,,,,acute kidney failure,,,,, -10008267,3260,,affects,,Nitric oxide,,,,lung disorder,,,,, -9982988,3261,,affects,,Nitric oxide,,,,respiratory failure,,,,, -9910920,3262,,affects,,Nitric oxide,,,,brain ischemia,,,,, -9742582,3263,,affects,,Nitric oxide,,,,stroke disorder,,,,, -9649727,3264,,affects,,Nitric oxide,,,,neoplasm,,,,, -9102608,3265,,affects,,Nitric oxide,,,,Hypoxemia,,,,, -9095187,3266,,affects,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, -8891949,3267,,affects,,Nitric oxide,,,,Sepsis,,,,, -8832872,3268,,affects,,Nitric oxide,,,,pneumonia,,,,, -8646255,3269,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, -8473168,3270,,affects,,Nitric oxide,,,,neoplasm,,,,, -8202584,3271,,affects,,Nitric oxide,,,,Sepsis,,,,, -8139693,3272,,affects,,Nitric oxide,,,,brain injury,,,,, -7935763,3273,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -7896362,3274,,affects,,Nitric oxide,,,,Inflammation,,,,, -7780898,3275,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -7712088,3276,,affects,,Nitric oxide,,,,Hypoxemia,,,,, -7542916,3277,,affects,,Nitric oxide,,,,anemia,,,,, -7169788,3278,,affects,,Nitric oxide,,,,Inflammation,,,,, -7164340,3279,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -7094195,3280,,affects,,Nitric oxide,,,,malaria,,,,, -20359925,3281,,produces,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -20299429,3282,,produces,,Nitric oxide,,,,pneumonia,,,,, -17925357,3283,,produces,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, -15219259,3284,,produces,,Nitric oxide,,,,Premature birth,,,,, -13106727,3285,,produces,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -12774415,3286,,produces,,Nitric oxide,,,,stroke disorder,,,,, -12205025,3287,,produces,,Nitric oxide,,,,Varicose Ulcer,,,,, -11786457,3288,,produces,,Nitric oxide,,,,brain ischemia,,,,, -9816411,3289,,produces,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, -8745644,3290,,produces,,Nitric oxide,,,,sickle cell anemia,,,,, -8339020,3291,,produces,,Nitric oxide,,,,acute kidney failure,,,,, -7963932,3292,,produces,,Nitric oxide,,,,cystic fibrosis,,,,, -7644756,3293,,produces,,Nitric oxide,,,,anemia,,,,, -7555266,3294,,produces,,Nitric oxide,,,,myocardial ischemia,,,,, -7511323,3295,,produces,,Nitric oxide,,,,myocardial infarction,,,,, -7507297,3296,,produces,,Nitric oxide,,,,Inflammation,,,,, -7461061,3297,,produces,,Nitric oxide,,,,Hypoxemia,,,,, -7435212,3298,,produces,,Nitric oxide,,,,neoplasm,,,,, -7390889,3299,,produces,,Nitric oxide,,,,Sepsis,,,,, -7094197,3300,,produces,,Nitric oxide,,,,malaria,,,,, -26705109,3301,,disrupts,,Nitric oxide,,,,anemia,,,,, -19923810,3302,,disrupts,,Nitric oxide,,,,stroke disorder,,,,, -14786185,3303,,disrupts,,Nitric oxide,,,,Sepsis,,,,, -12247489,3304,,disrupts,,Nitric oxide,,,,sickle cell anemia,,,,, -11088644,3305,,disrupts,,Nitric oxide,,,,cystic fibrosis,,,,, -10963665,3306,,disrupts,,Nitric oxide,,,,neoplasm,,,,, -10158293,3307,,disrupts,,Nitric oxide,,,,myocardial ischemia,,,,, -9091818,3308,,disrupts,,Nitric oxide,,,,respiratory failure,,,,, -8577648,3309,,disrupts,,Nitric oxide,,,,Inflammation,,,,, -7822328,3310,,disrupts,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -7750750,3311,,disrupts,,Nitric oxide,,,,myocardial infarction,,,,, -7555296,3312,,disrupts,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -7358959,3313,,disrupts,,Nitric oxide,,,,Hypoxemia,,,,, -26913950,3314,,prevents,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, -25277893,3315,,prevents,,Nitric oxide,,,,neuralgia,,,,, -22898445,3316,,prevents,,Nitric oxide,,,,Infection,,,,, -21669107,3317,,prevents,,Nitric oxide,,,,neoplasm,,,,, -21628822,3318,,prevents,,Nitric oxide,,,,Hypoxemia,,,,, -21494876,3319,,prevents,,Nitric oxide,,,,Inflammation,,,,, -21062009,3320,,prevents,,Nitric oxide,,,,pulmonary embolism,,,,, -16675253,3321,,prevents,,Nitric oxide,,,,stroke disorder,,,,, -13634130,3322,,prevents,,Nitric oxide,,,,sickle cell anemia,,,,, -11584828,3323,,prevents,,Nitric oxide,,,,brain ischemia,,,,, -11450951,3324,,prevents,,Nitric oxide,,,,myocardial infarction,,,,, -10887585,3325,,prevents,,Nitric oxide,,,,pneumonia,,,,, -9990816,3326,,prevents,,Nitric oxide,,,,acute kidney failure,,,,, -9464831,3327,,prevents,,Nitric oxide,,,,myocardial ischemia,,,,, -8988568,3328,,prevents,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -8396830,3329,,prevents,,Nitric oxide,,,,cystic fibrosis,,,,, -8224065,3330,,prevents,,Nitric oxide,,,,brain injury,,,,, -8045867,3331,,prevents,,Nitric oxide,,,,lung disorder,,,,, -7996843,3332,,prevents,,Nitric oxide,,,,Sepsis,,,,, -7713281,3333,,prevents,,Nitric oxide,,,,respiratory failure,,,,, -7103253,3334,,prevents,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -27558971,3335,,exacerbates,,Nitric oxide,,,,myocardial ischemia,,,,, -26883794,3336,,exacerbates,,Nitric oxide,,,,acute kidney failure,,,,, -24530593,3337,,exacerbates,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -23305196,3338,,predisposes,,Nitric oxide,,,,cystic fibrosis,,,,, -18515843,3339,,predisposes,,Nitric oxide,,,,malaria,,,,, -17339126,3340,,predisposes,,Nitric oxide,,,,stroke disorder,,,,, -17303048,3341,,predisposes,,Nitric oxide,,,,brain ischemia,,,,, -16438716,3342,,predisposes,,Nitric oxide,,,,respiratory system disorder,,,,, -16061041,3343,,predisposes,,Nitric oxide,,,,lung disorder,,,,, -15696584,3344,,predisposes,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, -13236015,3345,,predisposes,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, -12163328,3346,,predisposes,,Nitric oxide,,,,acute kidney failure,,,,, -12068938,3347,,predisposes,,Nitric oxide,,,,neuralgia,,,,, -11569688,3348,,predisposes,,Nitric oxide,,,,Premature birth,,,,, -9326529,3349,,predisposes,,Nitric oxide,,,,brain injury,,,,, -8098085,3350,,predisposes,,Nitric oxide,,,,neoplasm,,,,, -7895713,3351,,predisposes,,Nitric oxide,,,,pneumonia,,,,, -7863118,3352,,predisposes,,Nitric oxide,,,,Hypoxemia,,,,, -7644760,3353,,predisposes,,Nitric oxide,,,,anemia,,,,, -7373094,3354,,predisposes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, -7119398,3355,,predisposes,,Nitric oxide,,,,Inflammation,,,,, -18948956,3356,,related to,,CHORIOGONADOTROPIN ALFA,,,,ovarian hyperstimulation syndrome,,,,, -10437081,3357,,related to,,CHORIONIC GONADOTROPIN,,,,hypogonadism,,,,, -10427260,3358,,related to,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, -25953720,3359,,causes,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, -12680602,3360,,causes,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -19382665,3361,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -10661395,3362,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -11878666,3363,,produces,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, -19257969,3364,,causes,,Triclosan,,,,allergic disease,,,,, -17886883,3365,,affects,,Triclosan,,,,gingivitis,,,,, -9651026,3366,,disrupts,,Triclosan,,,,gingivitis,,,,, -16053270,3367,,prevents,,Triclosan,,,,allergic disease,,,,, -20585436,3368,,affects,,Povidone iodine,,,,stomatitis,,,,, -22182083,3369,,prevents,,Povidone iodine,,,,Infection,,,,, -22061199,3370,,prevents,,Povidone iodine,,,,dental caries,,,,, -20053240,3371,,prevents,,Povidone iodine,,,,keratitis,,,,, -25268747,3372,,related to,,Vinblastine,,,,acute myeloid leukemia,,,,, -24601120,3373,,related to,,Vinblastine,,,,leukemia,,,,, -17518639,3374,,related to,,Vinblastine,,,,testicular cancer,,,,, -11295996,3375,,related to,,Vinblastine,,,,melanoma,,,,, -10629211,3376,,related to,,Vinblastine,,,,castration-resistant prostate carcinoma,,,,, -9405598,3377,,related to,,Vinblastine,,,,glioma,,,,, -8887641,3378,,related to,,Vinblastine,,,,neoplasm,,,,, -8831546,3379,,related to,,Vinblastine,,,,renal cell carcinoma,,,,, -8248825,3380,,related to,,Vinblastine,,,,lymphoma,,,,, -8201846,3381,,related to,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, -7111310,3382,,related to,,Vinblastine,,,,Hodgkins lymphoma,,,,, -22913920,3383,,causes,,Vinblastine,,,,neoplasm,,,,, -14498052,3384,,affects,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, -12889760,3385,,affects,,Vinblastine,,,,renal cell carcinoma,,,,, -11723511,3386,,affects,,Vinblastine,,,,neoplasm,,,,, -19032862,3387,,disrupts,,Vinblastine,,,,neoplasm,,,,, -26195658,3388,,related to,,Desacetylvinblastine amide,,,,lymphoma,,,,, -26116904,3389,,related to,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, -25980030,3390,,related to,,Desacetylvinblastine amide,,,,small cell lung carcinoma,,,,, -26313629,3391,,affects,,Desacetylvinblastine amide,,,,neoplasm,,,,, -26201212,3392,,affects,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, -26302410,3393,,prevents,,Desacetylvinblastine amide,,,,neoplasm,,,,, -25951740,3394,,causes,,Diazoxide,,,,hyperinsulinism,,,,, -17059197,3395,,causes,,Diazoxide,,,,hypoglycemia,,,,, -25817473,3396,,affects,,Diazoxide,,,,hypertensive disorder,,,,, -20202762,3397,,affects,,Diazoxide,,,,obesity disorder,,,,, -11393233,3398,,affects,,Diazoxide,,,,hyperinsulinism,,,,, -8184004,3399,,affects,,Diazoxide,,,,hypoglycemia,,,,, -9572369,3400,,disrupts,,Diazoxide,,,,hyperinsulinism,,,,, -26286810,3401,,prevents,,Diazoxide,,,,hypoglycemia,,,,, -22404640,3402,,prevents,,Diazoxide,,,,hypertensive disorder,,,,, -19200973,3403,,prevents,,Diazoxide,,,,obesity disorder,,,,, -16737667,3404,,predisposes,,Diazoxide,,,,hypoglycemia,,,,, -14267417,3405,,affects,,Pantoprazole,,,,gastroesophageal reflux disease,,,,, -12160514,3406,,prevents,,Pantoprazole,,,,active peptic ulcer disease,,,,, -8423273,3407,,prevents,,Pantoprazole,,,,peptic ulcer disease,,,,, -7509578,3408,,prevents,,Pantoprazole,,,,ulcer disease,,,,, -21088628,3409,,predisposes,,Pantoprazole,,,,active peptic ulcer disease,,,,, -20047688,3410,,causes,,Lansoprazole,,,,gastric ulcer,,,,, -26544602,3411,,affects,,Lansoprazole,,,,peptic ulcer disease,,,,, -11547923,3412,,affects,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -10008124,3413,,affects,,Lansoprazole,,,,peptic esophagitis,,,,, -7314434,3414,,affects,,Lansoprazole,,,,Helicobacter pylori infectious disease,,,,, -9466998,3415,,disrupts,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -20033093,3416,,prevents,,Lansoprazole,,,,peptic ulcer disease,,,,, -15339719,3417,,prevents,,Lansoprazole,,,,duodenal ulcer,,,,, -9335785,3418,,prevents,,Lansoprazole,,,,gastric ulcer,,,,, -8183428,3419,,prevents,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -27664803,3420,,exacerbates,,Lansoprazole,,,,gastritis,,,,, -10008126,3421,,predisposes,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, -10345128,3422,,subclass of,,Omeprazole,,,,Omeprazole sulfone,,,,, -8512321,3423,,subclass of,,Omeprazole,,,,Hydroxyomeprazole,,,,, -27115212,3424,,related to,,Omeprazole,,,,Omeprazole sulfone,,,,, -12365583,3425,,related to,,Omeprazole,,,,gastric ulcer,,,,, -7744216,3426,,related to,,Omeprazole,,,,Hydroxyomeprazole,,,,, -26722672,3427,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, -9932953,3428,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, -22198908,3429,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, -13085286,3430,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, -27703677,3431,,causes,,Omeprazole,,,,anemia,,,,, -27298440,3432,,causes,,Omeprazole,,,,Hemorrhage,,,,, -24514538,3433,,causes,,Omeprazole,,,,peptic ulcer disease,,,,, -19641302,3434,,causes,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -15956000,3435,,causes,,Omeprazole,,,,esophagitis,,,,, -12187782,3436,,causes,,Omeprazole,,,,ulcer disease,,,,, -11135889,3437,,causes,,Omeprazole,,,,injury,,,,, -10813876,3438,,causes,,Omeprazole,,,,Cough,,,,, -8871402,3439,,causes,,Omeprazole,,,,gastric ulcer,,,,, -7272148,3440,,causes,,Omeprazole,,,,duodenal ulcer,,,,, -27758339,3441,,affects,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, -27758338,3442,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, -27758337,3443,,affects,,Omeprazole,,,,peptic esophagitis,,,,, -27733079,3444,,affects,,Omeprazole,,,,peptic esophagitis,,,,, -27346919,3445,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, -22440533,3446,,affects,,Omeprazole,,,,anemia,,,,, -18634760,3447,,affects,,Omeprazole,,,,Pain,,,,, -17967745,3448,,affects,,Omeprazole,,,,injury,,,,, -12114858,3449,,affects,,Omeprazole,,,,ulcer disease,,,,, -11576921,3450,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, -10321262,3451,,affects,,Omeprazole,,,,duodenal ulcer,,,,, -9976497,3452,,affects,,Omeprazole,,,,gastric ulcer,,,,, -8694897,3453,,affects,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, -8349380,3454,,affects,,Omeprazole,,,,Hemorrhage,,,,, -8349375,3455,,affects,,Omeprazole,,,,Hemorrhage,,,,, -7653505,3456,,affects,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -7572363,3457,,affects,,Omeprazole,,,,ulcer disease,,,,, -14345083,3458,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, -26726289,3459,,disrupts,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -26000029,3460,,disrupts,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, -20129793,3461,,disrupts,,Omeprazole,,,,Barrett esophagus,,,,, -19299462,3462,,disrupts,,Omeprazole,,,,active peptic ulcer disease,,,,, -15524012,3463,,disrupts,,Omeprazole,,,,peptic ulcer disease,,,,, -13078646,3464,,disrupts,,Omeprazole,,,,ulcer disease,,,,, -10891179,3465,,disrupts,,Omeprazole,,,,gastric ulcer,,,,, -10776897,3466,,disrupts,,Omeprazole,,,,duodenal ulcer,,,,, -8884340,3467,,disrupts,,Omeprazole,,,,esophagitis,,,,, -27690262,3468,,prevents,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, -27025148,3469,,prevents,,Omeprazole,,,,Cough,,,,, -26715213,3470,,prevents,,Omeprazole,,,,Pain,,,,, -16929638,3471,,prevents,,Omeprazole,,,,esophagitis,,,,, -15601042,3472,,prevents,,Omeprazole,,,,active peptic ulcer disease,,,,, -9292674,3473,,prevents,,Omeprazole,,,,peptic ulcer disease,,,,, -8884338,3474,,prevents,,Omeprazole,,,,peptic esophagitis,,,,, -8341772,3475,,prevents,,Omeprazole,,,,duodenal ulcer,,,,, -8169375,3476,,prevents,,Omeprazole,,,,injury,,,,, -7646984,3477,,prevents,,Omeprazole,,,,gastric ulcer,,,,, -7653510,3478,,prevents,,Omeprazole,,,,gastroesophageal reflux disease,,,,, -7332307,3479,,prevents,,Omeprazole,,,,ulcer disease,,,,, -24752030,3480,,predisposes,,Omeprazole,,,,type 2 diabetes mellitus,,,,, -21309680,3481,,predisposes,,Omeprazole,,,,melanoma,,,,, -20838741,3482,,predisposes,,Omeprazole,,,,Barrett esophagus,,,,, -12649375,3483,,affects,,Rabeprazole,,,,infectious disease,,,,, -11547924,3484,,affects,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, -15461842,3485,,disrupts,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, -16244495,3486,,prevents,,Rabeprazole,,,,peptic ulcer disease,,,,, -15354267,3487,,prevents,,Rabeprazole,,,,active peptic ulcer disease,,,,, -8397732,3488,,prevents,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, -23526790,3489,,causes,,Esomeprazole,,,,active peptic ulcer disease,,,,, -20333475,3490,,causes,,Esomeprazole,,,,preeclampsia,,,,, -15271081,3491,,causes,,Esomeprazole,,,,gastric ulcer,,,,, -22638872,3492,,affects,,Esomeprazole,,,,neoplasm,,,,, -20180848,3493,,affects,,Esomeprazole,,,,preeclampsia,,,,, -19360632,3494,,affects,,Esomeprazole,,,,ulcer disease,,,,, -18357402,3495,,affects,,Esomeprazole,,,,dyspepsia,,,,, -14247859,3496,,affects,,Esomeprazole,,,,gastric ulcer,,,,, -12902689,3497,,affects,,Esomeprazole,,,,Hemorrhage,,,,, -12902688,3498,,affects,,Esomeprazole,,,,Hemorrhage,,,,, -12527967,3499,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -12015567,3500,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -10805094,3501,,disrupts,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -15938697,3502,,prevents,,Esomeprazole,,,,gastric ulcer,,,,, -14015294,3503,,prevents,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, -13576722,3504,,prevents,,Esomeprazole,,,,peptic ulcer disease,,,,, -12321750,3505,,prevents,,Esomeprazole,,,,ulcer disease,,,,, -10396538,3506,,related to,,Roflumilast,,,,asthma,,,,, -21017284,3507,,causes,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, -21116198,3508,,affects,,Roflumilast,,,,obesity disorder,,,,, -12290110,3509,,affects,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, -12290109,3510,,affects,,Roflumilast,,,,asthma,,,,, -22432515,3511,,disrupts,,Roflumilast,,,,schizophrenia,,,,, -24502817,3512,,prevents,,Roflumilast,,,,obesity disorder,,,,, -17763098,3513,,prevents,,Roflumilast,,,,diabetic kidney disease,,,,, -15955656,3514,,prevents,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, -8310806,3515,,causes,,Meperidine,,,,Pain,,,,, -26434893,3516,,affects,,Meperidine,,,,Pain,,,,, -18658715,3517,,affects,,Meperidine,,,,Pain,,,,, -8345324,3518,,prevents,,Meperidine,,,,Pain,,,,, -21672389,3519,,affects,,Ketobemidone,,,,Pain,,,,, -11850764,3520,,related to,,Travoprost,,,,ocular hypertension,,,,, -12116829,3521,,physically interacts with,,Travoprost,,,,prostanoid FP receptor,,,,, -18294152,3522,,affects,,Travoprost,,,,ocular hypertension,,,,, -18294151,3523,,affects,,Travoprost,,,,glaucoma,,,,, -10166996,3524,,prevents,,Travoprost,,,,ocular hypertension,,,,, -10166995,3525,,prevents,,Travoprost,,,,open-angle glaucoma,,,,, -17904574,3526,,related to,,Tafluprost,,,,glaucoma,,,,, -15304153,3527,,related to,,Tafluprost,,,,ocular hypertension,,,,, -15304152,3528,,related to,,Tafluprost,,,,open-angle glaucoma,,,,, -14941475,3529,,physically interacts with,,Tafluprost,,,,prostanoid FP receptor,,,,, -14941474,3530,,disrupts,,Tafluprost,,,,ocular hypertension,,,,, -14941473,3531,,disrupts,,Tafluprost,,,,open-angle glaucoma,,,,, -14231277,3532,,affects,,Ramelteon,,,,insomnia,,,,, -21718213,3533,,prevents,,Ramelteon,,,,sleep-wake disorder,,,,, -22873470,3534,,related to,,Melatonin,,,,acute kidney failure,,,,, -22002909,3535,,related to,,Melatonin,,,,metabolic disease,,,,, -21777340,3536,,related to,,Melatonin,,,,Cognitive impairment,,,,, -18920431,3537,,related to,,Melatonin,,,,burn,,,,, -18846352,3538,,related to,,Melatonin,,,,skin disorder,,,,, -18613354,3539,,related to,,Melatonin,,,,Neonatal sepsis,,,,, -18189253,3540,,related to,,Melatonin,,,,necrotizing enterocolitis,,,,, -17471678,3541,,related to,,Melatonin,,,,"dermatitis, atopic",,,,, -17103445,3542,,related to,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, -16423098,3543,,related to,,Melatonin,,,,periodontitis,,,,, -16022569,3544,,related to,,Melatonin,,,,metabolic syndrome X,,,,, -15882605,3545,,related to,,Melatonin,,,,enuresis,,,,, -15709123,3546,,related to,,Melatonin,,,,fibromyalgia,,,,, -15665905,3547,,related to,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, -14933527,3548,,related to,,Melatonin,,,,autism spectrum disorder,,,,, -14875890,3549,,related to,,Melatonin,,,,pervasive developmental disorder,,,,, -14786958,3550,,related to,,Melatonin,,,,gastroesophageal reflux disease,,,,, -13857052,3551,,related to,,Melatonin,,,,ulcerative colitis,,,,, -13491215,3552,,related to,,Melatonin,,,,diabetes mellitus,,,,, -13407170,3553,,related to,,Melatonin,,,,periodontal disorder,,,,, -13365823,3554,,related to,,Melatonin,,,,tooth disorder,,,,, -12843346,3555,,related to,,Melatonin,,,,melanoma,,,,, -12132104,3556,,related to,,Melatonin,,,,irritable bowel syndrome,,,,, -11584899,3557,,related to,,Melatonin,,,,brain ischemia,,,,, -11533403,3558,,related to,,Melatonin,,,,hypertensive disorder,,,,, -11319171,3559,,related to,,Melatonin,,,,Pain,,,,, -11137637,3560,,related to,,Melatonin,,,,essential hypertension,,,,, -10685850,3561,,related to,,Melatonin,,,,major depressive disorder,,,,, -10528037,3562,,related to,,Melatonin,,,,multiple sclerosis,,,,, -10477010,3563,,related to,,Melatonin,,,,non-small cell lung carcinoma,,,,, -10371972,3564,,related to,,Melatonin,,,,delirium,,,,, -10204563,3565,,related to,,Melatonin,,,,depressive disorder,,,,, -9947492,3566,,related to,,Melatonin,,,,myocardial infarction,,,,, -9516882,3567,,related to,,Melatonin,,,,Parkinson disease,,,,, -9086006,3568,,related to,,Melatonin,,,,ischemia reperfusion injury,,,,, -9074687,3569,,related to,,Melatonin,,,,Sepsis,,,,, -8867365,3570,,related to,,Melatonin,,,,schizophrenia,,,,, -8780387,3571,,related to,,Melatonin,,,,insomnia,,,,, -8686098,3572,,related to,,Melatonin,,,,dementia,,,,, -8623112,3573,,related to,,Melatonin,,,,migraine disorder,,,,, -7795396,3574,,related to,,Melatonin,,,,injury,,,,, -7482169,3575,,related to,,Melatonin,,,,neoplasm,,,,, -7440685,3576,,related to,,Melatonin,,,,Fatigue,,,,, -7185935,3577,,related to,,Melatonin,,,,epilepsy,,,,, -7185921,3578,,related to,,Melatonin,,,,sleep-wake disorder,,,,, -26987553,3579,,causes,,Melatonin,,,,Fatigue,,,,, -24500836,3580,,causes,,Melatonin,,,,anxiety,,,,, -22662368,3581,,causes,,Melatonin,,,,dementia,,,,, -21258564,3582,,causes,,Melatonin,,,,multiple sclerosis,,,,, -19886996,3583,,causes,,Melatonin,,,,Cognitive impairment,,,,, -19573910,3584,,causes,,Melatonin,,,,periodontitis,,,,, -17837306,3585,,causes,,Melatonin,,,,metabolic disease,,,,, -17714427,3586,,causes,,Melatonin,,,,myocardial infarction,,,,, -16705153,3587,,causes,,Melatonin,,,,Sepsis,,,,, -15644359,3588,,causes,,Melatonin,,,,gastroesophageal reflux disease,,,,, -14831403,3589,,causes,,Melatonin,,,,periodontal disorder,,,,, -14171289,3590,,causes,,Melatonin,,,,Parkinson disease,,,,, -14078373,3591,,causes,,Melatonin,,,,hypertensive disorder,,,,, -13896033,3592,,causes,,Melatonin,,,,breast neoplasm,,,,, -13361926,3593,,causes,,Melatonin,,,,ischemia reperfusion injury,,,,, -13039360,3594,,causes,,Melatonin,,,,epilepsy,,,,, -12762592,3595,,causes,,Melatonin,,,,enuresis,,,,, -12275569,3596,,causes,,Melatonin,,,,diabetes mellitus,,,,, -12071557,3597,,causes,,Melatonin,,,,insomnia,,,,, -10432083,3598,,causes,,Melatonin,,,,migraine disorder,,,,, -10432067,3599,,causes,,Melatonin,,,,schizophrenia,,,,, -9114525,3600,,causes,,Melatonin,,,,neoplasm,,,,, -8785660,3601,,causes,,Melatonin,,,,depressive disorder,,,,, -8291971,3602,,causes,,Melatonin,,,,injury,,,,, -25620630,3603,,affects,,Melatonin,,,,Fatigue,,,,, -25259613,3604,,affects,,Melatonin,,,,atrial fibrillation,,,,, -24144792,3605,,affects,,Melatonin,,,,myocardial infarction,,,,, -24094187,3606,,affects,,Melatonin,,,,major depressive disorder,,,,, -23101890,3607,,affects,,Melatonin,,,,periodontitis,,,,, -22037016,3608,,affects,,Melatonin,,,,diabetes mellitus,,,,, -21523229,3609,,affects,,Melatonin,,,,anxiety,,,,, -21046382,3610,,affects,,Melatonin,,,,non-small cell lung carcinoma,,,,, -20888328,3611,,affects,,Melatonin,,,,autism spectrum disorder,,,,, -18858036,3612,,affects,,Melatonin,,,,Cognitive impairment,,,,, -18703578,3613,,affects,,Melatonin,,,,Marchiafava-Bignami disease,,,,, -18605461,3614,,affects,,Melatonin,,,,Neonatal sepsis,,,,, -18605459,3615,,affects,,Melatonin,,,,Neonatal sepsis,,,,, -18111864,3616,,affects,,Melatonin,,,,Hemorrhage,,,,, -17774103,3617,,affects,,Melatonin,,,,fibromyalgia,,,,, -17471677,3618,,affects,,Melatonin,,,,"dermatitis, atopic",,,,, -17402992,3619,,affects,,Melatonin,,,,Fatigue,,,,, -17199486,3620,,affects,,Melatonin,,,,Sepsis,,,,, -17103446,3621,,affects,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, -17112614,3622,,affects,,Melatonin,,,,ulcerative colitis,,,,, -16898660,3623,,affects,,Melatonin,,,,Cognitive impairment,,,,, -16300651,3624,,affects,,Melatonin,,,,depressive disorder,,,,, -16293202,3625,,affects,,Melatonin,,,,Hemorrhage,,,,, -16189615,3626,,affects,,Melatonin,,,,Cognitive impairment,,,,, -15390003,3627,,affects,,Melatonin,,,,delirium,,,,, -14400565,3628,,affects,,Melatonin,,,,burn,,,,, -14333232,3629,,affects,,Melatonin,,,,schizophrenia,,,,, -13430046,3630,,affects,,Melatonin,,,,epilepsy,,,,, -13158859,3631,,affects,,Melatonin,,,,tooth disorder,,,,, -12620684,3632,,affects,,Melatonin,,,,melanoma,,,,, -12473519,3633,,affects,,Melatonin,,,,Parkinson disease,,,,, -11739216,3634,,affects,,Melatonin,,,,sleep-wake disorder,,,,, -11451669,3635,,affects,,Melatonin,,,,depressive disorder,,,,, -10979770,3636,,affects,,Melatonin,,,,insomnia,,,,, -10516034,3637,,affects,,Melatonin,,,,Pain,,,,, -10432086,3638,,affects,,Melatonin,,,,multiple sclerosis,,,,, -10047665,3639,,affects,,Melatonin,,,,hypertensive disorder,,,,, -9535418,3640,,affects,,Melatonin,,,,injury,,,,, -9364224,3641,,affects,,Melatonin,,,,Pain,,,,, -9244581,3642,,affects,,Melatonin,,,,migraine disorder,,,,, -9153135,3643,,affects,,Melatonin,,,,diabetes mellitus,,,,, -9143737,3644,,affects,,Melatonin,,,,epilepsy,,,,, -9114510,3645,,affects,,Melatonin,,,,ischemia reperfusion injury,,,,, -8993003,3646,,affects,,Melatonin,,,,neoplasm,,,,, -8720758,3647,,affects,,Melatonin,,,,breast neoplasm,,,,, -8108047,3648,,affects,,Melatonin,,,,depressive disorder,,,,, -7564928,3649,,affects,,Melatonin,,,,neoplasm,,,,, -7382212,3650,,affects,,Melatonin,,,,brain ischemia,,,,, -26765396,3651,,produces,,Melatonin,,,,epilepsy,,,,, -22867260,3652,,produces,,Melatonin,,,,diabetes mellitus,,,,, -18240585,3653,,produces,,Melatonin,,,,ulcerative colitis,,,,, -17207380,3654,,produces,,Melatonin,,,,autism spectrum disorder,,,,, -17051558,3655,,produces,,Melatonin,,,,depressive disorder,,,,, -16192357,3656,,produces,,Melatonin,,,,sleep-wake disorder,,,,, -13817260,3657,,produces,,Melatonin,,,,Parkinson disease,,,,, -11388402,3658,,produces,,Melatonin,,,,neoplasm,,,,, -9153153,3659,,produces,,Melatonin,,,,hypertensive disorder,,,,, -8191029,3660,,produces,,Melatonin,,,,breast neoplasm,,,,, -24623673,3661,,disrupts,,Melatonin,,,,atrial fibrillation,,,,, -24220852,3662,,disrupts,,Melatonin,,,,metabolic disease,,,,, -22817547,3663,,disrupts,,Melatonin,,,,anxiety,,,,, -20966258,3664,,disrupts,,Melatonin,,,,Cognitive impairment,,,,, -20623050,3665,,disrupts,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, -19958338,3666,,disrupts,,Melatonin,,,,multiple sclerosis,,,,, -18007482,3667,,disrupts,,Melatonin,,,,Sepsis,,,,, -18002672,3668,,disrupts,,Melatonin,,,,Pain,,,,, -16753621,3669,,disrupts,,Melatonin,,,,sleep-wake disorder,,,,, -14914180,3670,,disrupts,,Melatonin,,,,melanoma,,,,, -14617999,3671,,disrupts,,Melatonin,,,,"dermatitis, atopic",,,,, -13855513,3672,,disrupts,,Melatonin,,,,Hemorrhage,,,,, -10721769,3673,,disrupts,,Melatonin,,,,depressive disorder,,,,, -10333555,3674,,disrupts,,Melatonin,,,,injury,,,,, -10294227,3675,,disrupts,,Melatonin,,,,breast neoplasm,,,,, -10070181,3676,,disrupts,,Melatonin,,,,brain ischemia,,,,, -10008170,3677,,disrupts,,Melatonin,,,,Marchiafava-Bignami disease,,,,, -8932328,3678,,disrupts,,Melatonin,,,,epilepsy,,,,, -7916082,3679,,disrupts,,Melatonin,,,,ischemia reperfusion injury,,,,, -7545973,3680,,disrupts,,Melatonin,,,,neoplasm,,,,, -24902716,3681,,prevents,,Melatonin,,,,stomatitis,,,,, -24687342,3682,,prevents,,Melatonin,,,,essential hypertension,,,,, -24623674,3683,,prevents,,Melatonin,,,,atrial fibrillation,,,,, -24368351,3684,,prevents,,Melatonin,,,,acute kidney failure,,,,, -23824121,3685,,prevents,,Melatonin,,,,dementia,,,,, -23122960,3686,,prevents,,Melatonin,,,,Cognitive impairment,,,,, -22817548,3687,,prevents,,Melatonin,,,,anxiety,,,,, -21718214,3688,,prevents,,Melatonin,,,,sleep-wake disorder,,,,, -20260777,3689,,prevents,,Melatonin,,,,Pain,,,,, -19640170,3690,,prevents,,Melatonin,,,,aortic aneurysm,,,,, -18396849,3691,,prevents,,Melatonin,,,,Sepsis,,,,, -18141997,3692,,prevents,,Melatonin,,,,metabolic disease,,,,, -16995162,3693,,prevents,,Melatonin,,,,metabolic syndrome X,,,,, -16549748,3694,,prevents,,Melatonin,,,,burn,,,,, -16245777,3695,,prevents,,Melatonin,,,,schizophrenia,,,,, -16232642,3696,,prevents,,Melatonin,,,,Marchiafava-Bignami disease,,,,, -15150085,3697,,prevents,,Melatonin,,,,depressive disorder,,,,, -14373042,3698,,prevents,,Melatonin,,,,Parkinson disease,,,,, -11616466,3699,,prevents,,Melatonin,,,,autism spectrum disorder,,,,, -11366467,3700,,prevents,,Melatonin,,,,migraine disorder,,,,, -11108260,3701,,prevents,,Melatonin,,,,hypertensive disorder,,,,, -11061121,3702,,prevents,,Melatonin,,,,insomnia,,,,, -10234923,3703,,prevents,,Melatonin,,,,breast neoplasm,,,,, -10127047,3704,,prevents,,Melatonin,,,,myocardial infarction,,,,, -9561452,3705,,prevents,,Melatonin,,,,diabetes mellitus,,,,, -9346845,3706,,prevents,,Melatonin,,,,delirium,,,,, -9336280,3707,,prevents,,Melatonin,,,,brain ischemia,,,,, -8678642,3708,,prevents,,Melatonin,,,,epilepsy,,,,, -8166782,3709,,prevents,,Melatonin,,,,ischemia reperfusion injury,,,,, -7622774,3710,,prevents,,Melatonin,,,,injury,,,,, -7545974,3711,,prevents,,Melatonin,,,,neoplasm,,,,, -19276524,3712,,exacerbates,,Melatonin,,,,diabetes mellitus,,,,, -7980097,3713,,exacerbates,,Melatonin,,,,brain ischemia,,,,, -27283551,3714,,predisposes,,Melatonin,,,,hypertensive disorder,,,,, -23266236,3715,,predisposes,,Melatonin,,,,epilepsy,,,,, -21026194,3716,,predisposes,,Melatonin,,,,migraine disorder,,,,, -20835242,3717,,predisposes,,Melatonin,,,,metabolic syndrome X,,,,, -20419573,3718,,predisposes,,Melatonin,,,,major depressive disorder,,,,, -19382519,3719,,predisposes,,Melatonin,,,,periodontal disorder,,,,, -18749948,3720,,predisposes,,Melatonin,,,,autism spectrum disorder,,,,, -18605458,3721,,predisposes,,Melatonin,,,,Neonatal sepsis,,,,, -18359560,3722,,predisposes,,Melatonin,,,,depressive disorder,,,,, -16852096,3723,,predisposes,,Melatonin,,,,diabetes mellitus,,,,, -15094135,3724,,predisposes,,Melatonin,,,,injury,,,,, -14875892,3725,,predisposes,,Melatonin,,,,pervasive developmental disorder,,,,, -11794031,3726,,predisposes,,Melatonin,,,,neoplasm,,,,, -11643546,3727,,predisposes,,Melatonin,,,,dementia,,,,, -10915746,3728,,predisposes,,Melatonin,,,,sleep-wake disorder,,,,, -10114913,3729,,predisposes,,Melatonin,,,,myocardial infarction,,,,, -12950718,3730,,related to,,RETEPLASE,,,,thrombotic disease,,,,, -7082056,3731,,related to,,RETEPLASE,,,,stroke disorder,,,,, -12026281,3732,,related to,,UROKINASE,,,,stroke disorder,,,,, -11808316,3733,,related to,,UROKINASE,,,,empyema,,,,, -9909017,3734,,related to,,UROKINASE,,,,pleural empyema,,,,, -9695495,3735,,related to,,UROKINASE,,,,thrombotic disease,,,,, -7757067,3736,,related to,,UROKINASE,,,,pulmonary embolism,,,,, -20949144,3737,,causes,,UROKINASE,,,,thrombotic disease,,,,, -7392657,3738,,causes,,UROKINASE,,,,pulmonary embolism,,,,, -26135964,3739,,affects,,UROKINASE,,,,pulmonary embolism,,,,, -25781305,3740,,affects,,UROKINASE,,,,thrombotic disease,,,,, -26885635,3741,,disrupts,,UROKINASE,,,,thrombotic disease,,,,, -11607211,3742,,prevents,,UROKINASE,,,,thrombotic disease,,,,, -8505599,3743,,prevents,,UROKINASE,,,,pulmonary embolism,,,,, -26334889,3744,,predisposes,,UROKINASE,,,,pulmonary embolism,,,,, -13797160,3745,,predisposes,,UROKINASE,,,,thrombotic disease,,,,, -13590349,3746,,causes,,Buspirone,,,,depressive disorder,,,,, -7712722,3747,,affects,,Buspirone,,,,depressive disorder,,,,, -7425584,3748,,affects,,Buspirone,,,,physiological sexual disorder,,,,, -19950288,3749,,disrupts,,Buspirone,,,,schizophrenia,,,,, -10992881,3750,,disrupts,,Buspirone,,,,anxiety,,,,, -19904227,3751,,related to,,Iodine,,,,thyroid tumor,,,,, -10048388,3752,,related to,,Iodine,,,,breast neoplasm,,,,, -10651106,3753,,causes,,Iodine,,,,thyroid tumor,,,,, -10745802,3754,,affects,,Iodine,,,,thyroid tumor,,,,, -24773674,3755,,prevents,,Iodine,,,,thyroid tumor,,,,, -27167996,3756,,predisposes,,Iodine,,,,thyroid tumor,,,,, -7362584,3757,,subclass of,,Acetaminophen,,,,Acetaminophen sulfate,,,,, -7362582,3758,,subclass of,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -26133523,3759,,related to,,Acetaminophen,,,,neoplasm,,,,, -25084939,3760,,related to,,Acetaminophen,,,,Acetimidoquinone,,,,, -24055705,3761,,related to,,Acetaminophen,,,,osteoarthritis,,,,, -20371329,3762,,related to,,Acetaminophen,,,,digestive system disorder,,,,, -19637295,3763,,related to,,Acetaminophen,,,,Renal Colic,,,,, -16009572,3764,,related to,,Acetaminophen,,,,rheumatoid arthritis,,,,, -12233599,3765,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -12541409,3766,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -15777318,3767,,coexists with,,Acetaminophen,,,,Acetimidoquinone,,,,, -18513016,3768,,derives from,,Acetaminophen,,,,Acetimidoquinone,,,,, -16596646,3769,,derives from,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -7891577,3770,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, -11100770,3771,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, -8441876,3772,,physically interacts with,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -25685005,3773,,causes,,Acetaminophen,,,,neoplasm,,,,, -24327037,3774,,causes,,Acetaminophen,,,,anxiety,,,,, -23482103,3775,,causes,,Acetaminophen,,,,nervous system disorder,,,,, -21920646,3776,,causes,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, -21160030,3777,,causes,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, -19409287,3778,,causes,,Acetaminophen,,,,myopia,,,,, -17485084,3779,,causes,,Acetaminophen,,,,obesity disorder,,,,, -17093716,3780,,causes,,Acetaminophen,,,,kidney disorder,,,,, -16903597,3781,,causes,,Acetaminophen,,,,hypertensive disorder,,,,, -16867510,3782,,causes,,Acetaminophen,,,,delirium,,,,, -16756158,3783,,causes,,Acetaminophen,,,,osteoarthritis,,,,, -16155885,3784,,causes,,Acetaminophen,,,,Hemorrhage,,,,, -15922778,3785,,causes,,Acetaminophen,,,,Pruritus,,,,, -14972793,3786,,causes,,Acetaminophen,,,,brain injury,,,,, -12302511,3787,,causes,,Acetaminophen,,,,Headache,,,,, -9507087,3788,,causes,,Acetaminophen,,,,Vomiting,,,,, -8697178,3789,,causes,,Acetaminophen,,,,Pain,,,,, -8697177,3790,,causes,,Acetaminophen,,,,Fever,,,,, -7330301,3791,,causes,,Acetaminophen,,,,injury,,,,, -24793249,3792,,affects,,Acetaminophen,,,,hypertensive disorder,,,,, -23912807,3793,,affects,,Acetaminophen,,,,Vomiting,,,,, -23912806,3794,,affects,,Acetaminophen,,,,Nausea,,,,, -23442508,3795,,affects,,Acetaminophen,,,,pharyngitis,,,,, -23226380,3796,,affects,,Acetaminophen,,,,anxiety,,,,, -22849168,3797,,affects,,Acetaminophen,,,,neoplasm,,,,, -22389406,3798,,affects,,Acetaminophen,,,,Low back pain,,,,, -22267005,3799,,affects,,Acetaminophen,,,,Acute Pain,,,,, -21609859,3800,,affects,,Acetaminophen,,,,migraine disorder,,,,, -21375424,3801,,affects,,Acetaminophen,,,,preeclampsia,,,,, -21166764,3802,,affects,,Acetaminophen,,,,Parkinson disease,,,,, -20477729,3803,,affects,,Acetaminophen,,,,Hemorrhage,,,,, -20447454,3804,,affects,,Acetaminophen,,,,rheumatoid arthritis,,,,, -19937801,3805,,affects,,Acetaminophen,,,,Pain,,,,, -19285056,3806,,affects,,Acetaminophen,,,,Renal Colic,,,,, -18899993,3807,,affects,,Acetaminophen,,,,Abdominal pain,,,,, -18709599,3808,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, -18394888,3809,,affects,,Acetaminophen,,,,Headache,,,,, -18298999,3810,,affects,,Acetaminophen,,,,patent ductus arteriosus,,,,, -16707575,3811,,affects,,Acetaminophen,,,,obesity disorder,,,,, -16662805,3812,,affects,,Acetaminophen,,,,Vomiting,,,,, -16662804,3813,,affects,,Acetaminophen,,,,Nausea,,,,, -15922777,3814,,affects,,Acetaminophen,,,,Pruritus,,,,, -15909356,3815,,affects,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, -12673406,3816,,affects,,Acetaminophen,,,,bone fracture,,,,, -12488756,3817,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -11625632,3818,,affects,,Acetaminophen,,,,Chronic pain,,,,, -11439823,3819,,affects,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, -11319146,3820,,affects,,Acetaminophen,,,,neuralgia,,,,, -11289717,3821,,affects,,Acetaminophen,,,,osteoarthritis,,,,, -11227783,3822,,affects,,Acetaminophen,,,,Fever,,,,, -11159989,3823,,affects,,Acetaminophen,,,,Hemorrhage,,,,, -10410536,3824,,affects,,Acetaminophen,,,,injury,,,,, -10195419,3825,,affects,,Acetaminophen,,,,Pain,,,,, -9259287,3826,,affects,,Acetaminophen,,,,Fever,,,,, -8642669,3827,,affects,,Acetaminophen,,,,Hemorrhage,,,,, -8097597,3828,,affects,,Acetaminophen,,,,injury,,,,, -25639149,3829,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, -20782169,3830,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, -25481457,3831,,disrupts,,Acetaminophen,,,,patent ductus arteriosus,,,,, -25355292,3832,,disrupts,,Acetaminophen,,,,delirium,,,,, -19614622,3833,,disrupts,,Acetaminophen,,,,Headache,,,,, -16273113,3834,,disrupts,,Acetaminophen,,,,Fever,,,,, -12102031,3835,,disrupts,,Acetaminophen,,,,Pain,,,,, -7794905,3836,,disrupts,,Acetaminophen,,,,influenza,,,,, -7640332,3837,,disrupts,,Acetaminophen,,,,injury,,,,, -26559635,3838,,prevents,,Acetaminophen,,,,malaria,,,,, -22159381,3839,,prevents,,Acetaminophen,,,,Hemorrhage,,,,, -22123298,3840,,prevents,,Acetaminophen,,,,Fever,,,,, -20154151,3841,,prevents,,Acetaminophen,,,,neuralgia,,,,, -20107193,3842,,prevents,,Acetaminophen,,,,delirium,,,,, -19168014,3843,,prevents,,Acetaminophen,,,,obesity disorder,,,,, -19006111,3844,,prevents,,Acetaminophen,,,,patent ductus arteriosus,,,,, -18131378,3845,,prevents,,Acetaminophen,,,,Low back pain,,,,, -18033682,3846,,prevents,,Acetaminophen,,,,Vomiting,,,,, -16975983,3847,,prevents,,Acetaminophen,,,,neoplasm,,,,, -16828191,3848,,prevents,,Acetaminophen,,,,rheumatoid arthritis,,,,, -16784082,3849,,prevents,,Acetaminophen,,,,injury,,,,, -16782348,3850,,prevents,,Acetaminophen,,,,Nausea,,,,, -15909357,3851,,prevents,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, -15525446,3852,,prevents,,Acetaminophen,,,,Acute Pain,,,,, -15467414,3853,,prevents,,Acetaminophen,,,,influenza,,,,, -14660734,3854,,prevents,,Acetaminophen,,,,cardiac rhythm disease,,,,, -14372292,3855,,prevents,,Acetaminophen,,,,Headache,,,,, -13804263,3856,,prevents,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, -8695490,3857,,prevents,,Acetaminophen,,,,Pain,,,,, -25567880,3858,,predisposes,,Acetaminophen,,,,Sepsis,,,,, -24917204,3859,,predisposes,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, -22230555,3860,,predisposes,,Acetaminophen,,,,delirium,,,,, -21723139,3861,,predisposes,,Acetaminophen,,,,Hemorrhage,,,,, -20594449,3862,,predisposes,,Acetaminophen,,,,neoplasm,,,,, -19914508,3863,,predisposes,,Acetaminophen,,,,Pain,,,,, -16209480,3864,,predisposes,,Acetaminophen,,,,kidney disorder,,,,, -13597848,3865,,predisposes,,Acetaminophen,,,,injury,,,,, -13536066,3866,,predisposes,,Acetaminophen,,,,non-small cell lung carcinoma,,,,, -12673403,3867,,predisposes,,Acetaminophen,,,,bone fracture,,,,, -12109634,3868,,predisposes,,Acetaminophen,,,,Parkinson disease,,,,, -11873681,3869,,predisposes,,Acetaminophen,,,,non-Hodgkin lymphoma,,,,, -9834508,3870,,predisposes,,Acetaminophen,,,,hypertensive disorder,,,,, -8862839,3871,,predisposes,,Acetaminophen,,,,streptococcal infection,,,,, -10289439,3872,,related to,,Chlorthalidone,,,,hypertensive disorder,,,,, -10185607,3873,,related to,,Chlorthalidone,,,,coronary artery disorder,,,,, -10185606,3874,,related to,,Chlorthalidone,,,,myocardial infarction,,,,, -7839079,3875,,related to,,Chlorthalidone,,,,essential hypertension,,,,, -21616164,3876,,affects,,Chlorthalidone,,,,myocardial infarction,,,,, -21616163,3877,,affects,,Chlorthalidone,,,,coronary artery disorder,,,,, -16399514,3878,,affects,,Chlorthalidone,,,,essential hypertension,,,,, -16281975,3879,,affects,,Chlorthalidone,,,,hypertensive disorder,,,,, -11587035,3880,,affects,,Chlorthalidone,,,,diabetes mellitus,,,,, -11095498,3881,,prevents,,Chlorthalidone,,,,myocardial infarction,,,,, -11095497,3882,,prevents,,Chlorthalidone,,,,coronary artery disorder,,,,, -8853238,3883,,prevents,,Chlorthalidone,,,,myocardial ischemia,,,,, -8036244,3884,,prevents,,Chlorthalidone,,,,hypertensive disorder,,,,, -11078982,3885,,predisposes,,Chlorthalidone,,,,coronary artery disorder,,,,, -19123757,3886,,causes,,Propacetamol,,,,Pain,,,,, -11402898,3887,,prevents,,Propacetamol,,,,Pain,,,,, -25540651,3888,,affects,,Isopropyl Alcohol,,,,Nausea,,,,, -18311094,3889,,affects,,Isopropyl Alcohol,,,,infectious disease,,,,, -10697335,3890,,affects,,Isopropyl Alcohol,,,,burn,,,,, -9427033,3891,,prevents,,Isopropyl Alcohol,,,,infectious disease,,,,, -21320482,3892,,related to,,Ethanol,,,,substance-related disorder,,,,, -15908919,3893,,related to,,Ethanol,,,,hypertensive disorder,,,,, -14538852,3894,,related to,,Ethanol,,,,atrial fibrillation,,,,, -13852361,3895,,related to,,Ethanol,,,,obesity disorder,,,,, -27116018,3896,,causes,,Ethanol,,,,neutropenia,,,,, -26520376,3897,,causes,,Ethanol,,,,essential hypertension,,,,, -17336935,3898,,causes,,Ethanol,,,,Tremor,,,,, -15073107,3899,,causes,,Ethanol,,,,alcohol-related disorders,,,,, -14779551,3900,,causes,,Ethanol,,,,burn,,,,, -12227250,3901,,causes,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, -11665347,3902,,causes,,Ethanol,,,,erectile dysfunction,,,,, -11096896,3903,,causes,,Ethanol,,,,type 2 diabetes mellitus,,,,, -10962858,3904,,causes,,Ethanol,,,,atrial fibrillation,,,,, -9159992,3905,,causes,,Ethanol,,,,obesity disorder,,,,, -8743651,3906,,causes,,Ethanol,,,,alcohol abuse,,,,, -8636726,3907,,causes,,Ethanol,,,,major depressive disorder,,,,, -8268450,3908,,causes,,Ethanol,,,,atopic eczema,,,,, -7771647,3909,,causes,,Ethanol,,,,hypertensive disorder,,,,, -7460012,3910,,causes,,Ethanol,,,,cirrhosis of liver,,,,, -27580478,3911,,affects,,Ethanol,,,,cirrhosis of liver,,,,, -27514790,3912,,affects,,Ethanol,,,,Thyroid nodule,,,,, -26762447,3913,,affects,,Ethanol,,,,neutropenia,,,,, -23912654,3914,,affects,,Ethanol,,,,atrial fibrillation,,,,, -23763968,3915,,affects,,Ethanol,,,,substance-related disorder,,,,, -19533165,3916,,affects,,Ethanol,,,,hypertensive disorder,,,,, -19155713,3917,,affects,,Ethanol,,,,cannabis dependence,,,,, -16819917,3918,,affects,,Ethanol,,,,Chronic pain,,,,, -15671844,3919,,affects,,Ethanol,,,,obesity disorder,,,,, -14737169,3920,,affects,,Ethanol,,,,Chronic pain,,,,, -14527564,3921,,affects,,Ethanol,,,,benign prostatic hyperplasia,,,,, -13226372,3922,,affects,,Ethanol,,,,atrial fibrillation,,,,, -12698965,3923,,affects,,Ethanol,,,,major depressive disorder,,,,, -12166837,3924,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, -10697334,3925,,affects,,Ethanol,,,,burn,,,,, -9822489,3926,,affects,,Ethanol,,,,Tremor,,,,, -9174558,3927,,affects,,Ethanol,,,,Tremor,,,,, -9116052,3928,,affects,,Ethanol,,,,major depressive disorder,,,,, -8931619,3929,,affects,,Ethanol,,,,hypertensive disorder,,,,, -8730041,3930,,affects,,Ethanol,,,,burn,,,,, -8616967,3931,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, -8569555,3932,,affects,,Ethanol,,,,alcohol abuse,,,,, -8363507,3933,,affects,,Ethanol,,,,obesity disorder,,,,, -7210977,3934,,affects,,Ethanol,,,,alcohol abuse,,,,, -25366419,3935,,disrupts,,Ethanol,,,,ventricular tachycardia,,,,, -24747388,3936,,disrupts,,Ethanol,,,,obesity disorder,,,,, -22793590,3937,,disrupts,,Ethanol,,,,Infection,,,,, -20664067,3938,,disrupts,,Ethanol,,,,Chronic pain,,,,, -19084276,3939,,disrupts,,Ethanol,,,,hypertensive disorder,,,,, -15586620,3940,,disrupts,,Ethanol,,,,Tremor,,,,, -15580442,3941,,disrupts,,Ethanol,,,,atrial fibrillation,,,,, -12535146,3942,,disrupts,,Ethanol,,,,type 2 diabetes mellitus,,,,, -9920913,3943,,disrupts,,Ethanol,,,,constipation disorder,,,,, -27717904,3944,,prevents,,Ethanol,,,,cirrhosis of liver,,,,, -22976273,3945,,prevents,,Ethanol,,,,Infection,,,,, -21338360,3946,,prevents,,Ethanol,,,,atrial fibrillation,,,,, -20664068,3947,,prevents,,Ethanol,,,,Chronic pain,,,,, -14465260,3948,,prevents,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, -13158318,3949,,prevents,,Ethanol,,,,erectile dysfunction,,,,, -12078103,3950,,prevents,,Ethanol,,,,alcohol abuse,,,,, -11890775,3951,,prevents,,Ethanol,,,,type 2 diabetes mellitus,,,,, -11547578,3952,,prevents,,Ethanol,,,,Tremor,,,,, -10032139,3953,,prevents,,Ethanol,,,,obesity disorder,,,,, -8207881,3954,,prevents,,Ethanol,,,,hypertensive disorder,,,,, -26228661,3955,,predisposes,,Ethanol,,,,essential hypertension,,,,, -23006394,3956,,predisposes,,Ethanol,,,,constipation disorder,,,,, -21458894,3957,,predisposes,,Ethanol,,,,burn,,,,, -21015200,3958,,predisposes,,Ethanol,,,,benign prostatic hyperplasia,,,,, -20014749,3959,,predisposes,,Ethanol,,,,neuroblastoma,,,,, -19550164,3960,,predisposes,,Ethanol,,,,endometriosis,,,,, -15239058,3961,,predisposes,,Ethanol,,,,cannabis dependence,,,,, -13742110,3962,,predisposes,,Ethanol,,,,cirrhosis of liver,,,,, -13158317,3963,,predisposes,,Ethanol,,,,erectile dysfunction,,,,, -11801709,3964,,predisposes,,Ethanol,,,,type 2 diabetes mellitus,,,,, -11652545,3965,,predisposes,,Ethanol,,,,obesity disorder,,,,, -11461204,3966,,predisposes,,Ethanol,,,,atrial fibrillation,,,,, -9864711,3967,,predisposes,,Ethanol,,,,major depressive disorder,,,,, -9226083,3968,,predisposes,,Ethanol,,,,alcohol abuse,,,,, -8895200,3969,,predisposes,,Ethanol,,,,hypertensive disorder,,,,, -22402878,3970,,related to,,Sodium Hypochlorite,,,,Infection,,,,, -22402879,3971,,prevents,,Sodium Hypochlorite,,,,Infection,,,,, -22325598,3972,,prevents,,Sodium Hypochlorite,,,,Pain,,,,, -23522159,3973,,related to,,Hydrogen Peroxide,,,,gingivitis,,,,, -10185817,3974,,related to,,Hydrogen Peroxide,,,,acne,,,,, -9091124,3975,,related to,,Hydrogen Peroxide,,,,injury,,,,, -21979927,3976,,causes,,Hydrogen Peroxide,,,,seborrheic keratosis,,,,, -7121153,3977,,causes,,Hydrogen Peroxide,,,,injury,,,,, -18988282,3978,,affects,,Hydrogen Peroxide,,,,severe acute respiratory syndrome,,,,, -15261236,3979,,affects,,Hydrogen Peroxide,,,,gingivitis,,,,, -9489971,3980,,affects,,Hydrogen Peroxide,,,,injury,,,,, -7188934,3981,,affects,,Hydrogen Peroxide,,,,injury,,,,, -20490056,3982,,disrupts,,Hydrogen Peroxide,,,,dental caries,,,,, -17081431,3983,,disrupts,,Hydrogen Peroxide,,,,injury,,,,, -8804977,3984,,disrupts,,Hydrogen Peroxide,,,,gingivitis,,,,, -21124110,3985,,prevents,,Hydrogen Peroxide,,,,acne,,,,, -11091070,3986,,prevents,,Hydrogen Peroxide,,,,gingivitis,,,,, -7482647,3987,,prevents,,Hydrogen Peroxide,,,,injury,,,,, -19925807,3988,,predisposes,,Hydrogen Peroxide,,,,dental caries,,,,, -10852631,3989,,predisposes,,Hydrogen Peroxide,,,,injury,,,,, -23181733,3990,,related to,,Vitamin K1,,,,Hemorrhage,,,,, -20221966,3991,,related to,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, -19764095,3992,,related to,,Vitamin K1,,,,osteoporosis,,,,, -17682094,3993,,related to,,Vitamin K1,,,,atrial fibrillation,,,,, -13777524,3994,,related to,,Vitamin K1,,,,cystic fibrosis,,,,, -11304774,3995,,affects,,Vitamin K1,,,,Hemorrhage,,,,, -24408540,3996,,prevents,,Vitamin K1,,,,Hemorrhage,,,,, -13476259,3997,,prevents,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, -10772424,3998,,predisposes,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, -9319754,3999,,predisposes,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, -24430542,4000,,causes,,Indapamide,,,,type 2 diabetes mellitus,,,,, -24430545,4001,,affects,,Indapamide,,,,type 2 diabetes mellitus,,,,, -10214767,4002,,affects,,Indapamide,,,,hypertensive disorder,,,,, -13327254,4003,,prevents,,Indapamide,,,,hypertensive disorder,,,,, -18173402,4004,,related to,,Perphenazine,,,,schizophrenia,,,,, -11307427,4005,,related to,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, -19924977,4006,,disrupts,,Perphenazine,,,,cocaine dependence,,,,, -19924976,4007,,disrupts,,Perphenazine,,,,schizophrenia,,,,, -15171439,4008,,prevents,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, -27208453,4009,,exacerbates,,Perphenazine,,,,dementia,,,,, -26847530,4010,,affects,,Fluphenazine,,,,psychotic disorder,,,,, -11127872,4011,,prevents,,Fluphenazine,,,,psychotic disorder,,,,, -10396371,4012,,disrupts,,Prochlorperazine,,,,Nausea,,,,, -11808182,4013,,prevents,,Prochlorperazine,,,,Postoperative Nausea and Vomiting,,,,, -10634177,4014,,prevents,,Prochlorperazine,,,,migraine disorder,,,,, -7427448,4015,,prevents,,Prochlorperazine,,,,Nausea,,,,, -11272109,4016,,related to,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, -26291786,4017,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, -26291786,4018,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, -16241796,4019,,physically interacts with,,ELOSULFASE ALFA,,,,Keratan,,,,, -16652816,4020,,causes,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, -13130107,4021,,affects,,ELOSULFASE ALFA,,,,Keratan,,,,, -21593588,4022,,related to,,Pegvaliase,,,,phenylketonuria,,,,, -23111774,4023,,related to,,Labetalol,,,,preeclampsia,,,,, -19865755,4024,,related to,,Labetalol,,,,hypertensive disorder,,,,, -19886747,4025,,causes,,Labetalol,,,,hypertensive disorder,,,,, -7968423,4026,,causes,,Labetalol,,,,hypotensive disorder,,,,, -26371124,4027,,affects,,Labetalol,,,,hypertensive disorder,,,,, -16245918,4028,,affects,,Labetalol,,,,stroke disorder,,,,, -15472186,4029,,affects,,Labetalol,,,,hypertensive disorder,,,,, -11424839,4030,,affects,,Labetalol,,,,hypotensive disorder,,,,, -24194004,4031,,prevents,,Labetalol,,,,preeclampsia,,,,, -16282554,4032,,prevents,,Labetalol,,,,hypertensive disorder,,,,, -16892434,4033,,predisposes,,Labetalol,,,,stroke disorder,,,,, -15232781,4034,,related to,,Carvedilol,,,,hypertensive disorder,,,,, -15407113,4035,,causes,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -14049404,4036,,causes,,Carvedilol,,,,epilepsy,,,,, -19046224,4037,,affects,,Carvedilol,,,,esophageal varices,,,,, -17542363,4038,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -11530189,4039,,affects,,Carvedilol,,,,essential hypertension,,,,, -11200172,4040,,affects,,Carvedilol,,,,atrial fibrillation,,,,, -10614289,4041,,affects,,Carvedilol,,,,Stable angina,,,,, -10614288,4042,,affects,,Carvedilol,,,,hypertensive disorder,,,,, -10402879,4043,,affects,,Carvedilol,,,,hypertensive disorder,,,,, -9269217,4044,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -9116913,4045,,affects,,Carvedilol,,,,cardiovascular disorder,,,,, -7256243,4046,,affects,,Carvedilol,,,,portal hypertension,,,,, -24587957,4047,,disrupts,,Carvedilol,,,,portal hypertension,,,,, -21108262,4048,,disrupts,,Carvedilol,,,,myocardial infarction,,,,, -13210472,4049,,disrupts,,Carvedilol,,,,atrial fibrillation,,,,, -23631897,4050,,prevents,,Carvedilol,,,,neoplasm,,,,, -23413400,4051,,prevents,,Carvedilol,,,,myocardial infarction,,,,, -20796578,4052,,prevents,,Carvedilol,,,,hypoglycemia,,,,, -17416516,4053,,prevents,,Carvedilol,,,,portal hypertension,,,,, -15996194,4054,,prevents,,Carvedilol,,,,hypertensive disorder,,,,, -15794060,4055,,prevents,,Carvedilol,,,,Abnormal left ventricular function,,,,, -15707001,4056,,prevents,,Carvedilol,,,,kidney disorder,,,,, -12564717,4057,,prevents,,Carvedilol,,,,atrial fibrillation,,,,, -8686828,4058,,prevents,,Carvedilol,,,,Left ventricular hypertrophy,,,,, -23747042,4059,,predisposes,,Carvedilol,,,,type 2 diabetes mellitus,,,,, -22663350,4060,,predisposes,,Carvedilol,,,,atrial fibrillation,,,,, -21640789,4061,,predisposes,,Carvedilol,,,,hypoglycemia,,,,, -21331523,4062,,predisposes,,Carvedilol,,,,myocardial infarction,,,,, -20291576,4063,,related to,,Raloxifene,,,,schizophrenia,,,,, -13558027,4064,,related to,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -27583128,4065,,causes,,Raloxifene,,,,breast neoplasm,,,,, -20242808,4066,,affects,,Raloxifene,,,,psychotic disorder,,,,, -16098538,4067,,affects,,Raloxifene,,,,schizophrenia,,,,, -15267794,4068,,affects,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, -11233936,4069,,affects,,Raloxifene,,,,breast neoplasm,,,,, -10869334,4070,,affects,,Raloxifene,,,,osteoporosis,,,,, -9569313,4071,,affects,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -15267792,4072,,disrupts,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, -13369623,4073,,disrupts,,Raloxifene,,,,osteoporosis,,,,, -7874352,4074,,disrupts,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -16984197,4075,,prevents,,Raloxifene,,,,Alzheimer disease,,,,, -12036378,4076,,prevents,,Raloxifene,,,,breast neoplasm,,,,, -7813032,4077,,prevents,,Raloxifene,,,,postmenopausal osteoporosis,,,,, -7578651,4078,,prevents,,Raloxifene,,,,osteoporosis,,,,, -7570810,4079,,prevents,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, -11746046,4080,,predisposes,,Raloxifene,,,,Alzheimer disease,,,,, -11350173,4081,,predisposes,,Raloxifene,,,,osteoporosis,,,,, -23481448,4082,,prevents,,Bazedoxifene acetate,,,,osteoporosis,,,,, -19905553,4083,,disrupts,,Ospemifene,,,,psychologic dyspareunia,,,,, -15516940,4084,,affects,,Sufentanil,,,,Pain,,,,, -20743116,4085,,prevents,,Sufentanil,,,,delirium,,,,, -8151024,4086,,prevents,,Sufentanil,,,,Pain,,,,, -12819365,4087,,related to,,Streptomycin,,,,Buruli ulcer disease,,,,, -11425591,4088,,related to,,Streptomycin,,,,osteomyelitis,,,,, -10417352,4089,,related to,,Streptomycin,,,,plague,,,,, -10748245,4090,,causes,,Streptomycin,,,,plague,,,,, -26655494,4091,,prevents,,Streptomycin,,,,mycobacterium avium complex disease,,,,, -14226518,4092,,related to,,Paromomycin,,,,cutaneous leishmaniasis,,,,, -12550860,4093,,related to,,Paromomycin,,,,visceral leishmaniasis,,,,, -24692385,4094,,affects,,Paromomycin,,,,leishmaniasis,,,,, -23700620,4095,,affects,,Paromomycin,,,,visceral leishmaniasis,,,,, -22567030,4096,,affects,,Paromomycin,,,,cutaneous leishmaniasis,,,,, -27729096,4097,,related to,,Kanamycin,,,,bacterial infectious disease,,,,, -10553348,4098,,related to,,Kanamycin,,,,tuberculosis,,,,, -10567002,4099,,affects,,Kanamycin,,,,tuberculosis,,,,, -25418796,4100,,related to,,Vancomycin,,,,ulcerative colitis,,,,, -24528866,4101,,related to,,Vancomycin,,,,bacterial infectious disease,,,,, -23989025,4102,,related to,,Vancomycin,,,,Inflammation,,,,, -22667296,4103,,related to,,Vancomycin,,,,arthropathy,,,,, -21740759,4104,,related to,,Vancomycin,,,,Infection,,,,, -20543239,4105,,related to,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, -20099844,4106,,related to,,Vancomycin,,,,cystic fibrosis,,,,, -18717834,4107,,related to,,Vancomycin,,,,eye infectious disorder,,,,, -18563763,4108,,related to,,Vancomycin,,,,staphylococcal pneumonia,,,,, -17578296,4109,,related to,,Vancomycin,,,,Peptidoglycan,,,,, -17578296,4110,,related to,,Vancomycin,,,,Peptidoglycan,,,,, -15843803,4111,,related to,,Vancomycin,,,,Diabetic Foot,,,,, -15502624,4112,,related to,,Vancomycin,,,,abscess,,,,, -15448370,4113,,related to,,Vancomycin,,,,obesity disorder,,,,, -15389679,4114,,related to,,Vancomycin,,,,osteomyelitis,,,,, -15008716,4115,,related to,,Vancomycin,,,,peritonitis,,,,, -14607992,4116,,related to,,Vancomycin,,,,pneumonia,,,,, -14564943,4117,,related to,,Vancomycin,,,,gram-positive bacterial infections,,,,, -11348824,4118,,related to,,Vancomycin,,,,kidney failure,,,,, -11195361,4119,,related to,,Vancomycin,,,,Neonatal sepsis,,,,, -10946982,4120,,related to,,Vancomycin,,,,respiratory tract infectious disorder,,,,, -10225522,4121,,related to,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, -9057886,4122,,related to,,Vancomycin,,,,nosocomial infection,,,,, -9057885,4123,,related to,,Vancomycin,,,,staphylococcal infection,,,,, -8859000,4124,,related to,,Vancomycin,,,,endocarditis,,,,, -8170422,4125,,related to,,Vancomycin,,,,Sepsis,,,,, -23445509,4126,,related to,,Vancomycin,,,,peritonitis,,,,, -22719539,4127,,related to,,Vancomycin,,,,Infection,,,,, -11098147,4128,,related to,,Vancomycin,,,,Inflammation,,,,, -14094746,4129,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, -14094746,4130,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, -7840667,4131,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, -7710804,4132,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, -26896148,4133,,causes,,Vancomycin,,,,endocarditis,,,,, -26320414,4134,,causes,,Vancomycin,,,,enterocolitis,,,,, -22849619,4135,,causes,,Vancomycin,,,,Infection,,,,, -22231760,4136,,causes,,Vancomycin,,,,Inflammation,,,,, -21632936,4137,,causes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, -18945219,4138,,causes,,Vancomycin,,,,peritonitis,,,,, -15481792,4139,,causes,,Vancomycin,,,,skin disorder,,,,, -12001625,4140,,causes,,Vancomycin,,,,kidney failure,,,,, -9570250,4141,,causes,,Vancomycin,,,,nosocomial infection,,,,, -23893373,4142,,affects,,Vancomycin,,,,Infection,,,,, -21581118,4143,,affects,,Vancomycin,,,,Infection,,,,, -21291384,4144,,affects,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, -20283933,4145,,affects,,Vancomycin,,,,enterocolitis,,,,, -19879029,4146,,affects,,Vancomycin,,,,cystic fibrosis,,,,, -16899271,4147,,affects,,Vancomycin,,,,Sepsis,,,,, -15270589,4148,,affects,,Vancomycin,,,,peritonitis,,,,, -13735180,4149,,affects,,Vancomycin,,,,pneumonia,,,,, -12348278,4150,,affects,,Vancomycin,,,,Sepsis,,,,, -12348277,4151,,affects,,Vancomycin,,,,osteomyelitis,,,,, -12348276,4152,,affects,,Vancomycin,,,,endocarditis,,,,, -7991855,4153,,affects,,Vancomycin,,,,Peptidoglycan,,,,, -7527991,4154,,affects,,Vancomycin,,,,pneumonia,,,,, -17707788,4155,,affects,,Vancomycin,,,,Peptidoglycan,,,,, -22719533,4156,,disrupts,,Vancomycin,,,,Infection,,,,, -21036263,4157,,disrupts,,Vancomycin,,,,osteomyelitis,,,,, -19924841,4158,,disrupts,,Vancomycin,,,,Inflammation,,,,, -14538194,4159,,disrupts,,Vancomycin,,,,enterocolitis,,,,, -21888394,4160,,prevents,,Vancomycin,,,,bacterial infectious disease,,,,, -21518539,4161,,prevents,,Vancomycin,,,,Infection,,,,, -21292683,4162,,prevents,,Vancomycin,,,,osteomyelitis,,,,, -20759704,4163,,prevents,,Vancomycin,,,,kidney failure,,,,, -20759520,4164,,prevents,,Vancomycin,,,,arthropathy,,,,, -16424860,4165,,prevents,,Vancomycin,,,,pneumonia,,,,, -11136130,4166,,prevents,,Vancomycin,,,,nosocomial infection,,,,, -8520533,4167,,prevents,,Vancomycin,,,,peritonitis,,,,, -8203212,4168,,prevents,,Vancomycin,,,,endocarditis,,,,, -8170423,4169,,prevents,,Vancomycin,,,,Neonatal sepsis,,,,, -8170420,4170,,prevents,,Vancomycin,,,,Sepsis,,,,, -7111089,4171,,prevents,,Vancomycin,,,,Inflammation,,,,, -25178384,4172,,exacerbates,,Vancomycin,,,,Inflammation,,,,, -21622859,4173,,exacerbates,,Vancomycin,,,,pneumonia,,,,, -21314122,4174,,predisposes,,Vancomycin,,,,Sepsis,,,,, -19879549,4175,,predisposes,,Vancomycin,,,,kidney failure,,,,, -18555479,4176,,predisposes,,Vancomycin,,,,pneumonia,,,,, -18327103,4177,,predisposes,,Vancomycin,,,,nosocomial infection,,,,, -12689487,4178,,predisposes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, -12018679,4179,,related to,,LENOGRASTIM,,,,plasma cell myeloma,,,,, -24207855,4180,,related to,,SARGRAMOSTIM,,,,pulmonary alveolar proteinosis,,,,, -23712911,4181,,related to,,SARGRAMOSTIM,,,,Sepsis,,,,, -23712910,4182,,related to,,SARGRAMOSTIM,,,,adult acute respiratory distress syndrome,,,,, -23177848,4183,,related to,,SARGRAMOSTIM,,,,Alzheimer disease,,,,, -16827749,4184,,related to,,SARGRAMOSTIM,,,,prostate cancer,,,,, -11846978,4185,,related to,,SARGRAMOSTIM,,,,Crohn disease,,,,, -7671811,4186,,related to,,SARGRAMOSTIM,,,,HIV infectious disease,,,,, -7896656,4187,,prevents,,SARGRAMOSTIM,,,,neutropenia,,,,, -27611311,4188,,related to,,Filgrastim,,,,sarcoma,,,,, -26602673,4189,,related to,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, -26505391,4190,,related to,,Filgrastim,,,,Hodgkins lymphoma,,,,, -23038064,4191,,related to,,Filgrastim,,,,Infection,,,,, -22749433,4192,,related to,,Filgrastim,,,,neoplasm,,,,, -19713781,4193,,related to,,Filgrastim,,,,lymphoma,,,,, -18903615,4194,,related to,,Filgrastim,,,,HIV infectious disease,,,,, -17402873,4195,,related to,,Filgrastim,,,,acute myeloid leukemia,,,,, -16080456,4196,,related to,,Filgrastim,,,,plasma cell myeloma,,,,, -14467347,4197,,related to,,Filgrastim,,,,myocardial infarction,,,,, -13860825,4198,,related to,,Filgrastim,,,,small cell lung carcinoma,,,,, -10253688,4199,,related to,,Filgrastim,,,,ovarian cancer,,,,, -9334871,4200,,related to,,Filgrastim,,,,non-small cell lung carcinoma,,,,, -7868897,4201,,related to,,Filgrastim,,,,neutropenia,,,,, -7775323,4202,,related to,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, -13176527,4203,,has part,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, -27488127,4204,,causes,,Filgrastim,,,,acute myeloid leukemia,,,,, -26596932,4205,,causes,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, -19245347,4206,,causes,,Filgrastim,,,,myeloproliferative neoplasm,,,,, -8419399,4207,,causes,,Filgrastim,,,,neutropenia,,,,, -26496059,4208,,affects,,Filgrastim,,,,neutropenia,,,,, -15351355,4209,,affects,,Filgrastim,,,,Fever,,,,, -7868413,4210,,affects,,Filgrastim,,,,neutropenia,,,,, -9501874,4211,,disrupts,,Filgrastim,,,,neutropenia,,,,, -14309803,4212,,prevents,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, -7265196,4213,,prevents,,Filgrastim,,,,neutropenia,,,,, -16134815,4214,,predisposes,,Filgrastim,,,,hematopoietic and lymphoid system neoplasm,,,,, -14495646,4215,,predisposes,,Filgrastim,,,,neutropenia,,,,, -12306052,4216,,affects,,Tibolone,,,,physiological sexual disorder,,,,, -7873396,4217,,prevents,,Tibolone,,,,osteoporosis,,,,, -17565484,4218,,affects,,Cosyntropin,,,,West syndrome,,,,, -11757081,4219,,disrupts,,Cosyntropin,,,,hypertensive disorder,,,,, -19585114,4220,,related to,,Corticotropin,,,,chronic progressive multiple sclerosis,,,,, -15839924,4221,,related to,,Corticotropin,,,,membranous glomerulonephritis,,,,, -10947313,4222,,related to,,Corticotropin,,,,polycystic ovary syndrome,,,,, -10518316,4223,,related to,,Corticotropin,,,,dermatomyositis,,,,, -10489579,4224,,related to,,Corticotropin,,,,epilepsy,,,,, -10438408,4225,,related to,,Corticotropin,,,,nephrotic syndrome,,,,, -10431205,4226,,related to,,Corticotropin,,,,sarcoidosis,,,,, -10427009,4227,,related to,,Corticotropin,,,,optic neuritis,,,,, -9718321,4228,,related to,,Corticotropin,,,,rheumatoid arthritis,,,,, -8496620,4229,,related to,,Corticotropin,,,,multiple sclerosis,,,,, -7394246,4230,,related to,,Corticotropin,,,,West syndrome,,,,, -22849896,4231,,causes,,Corticotropin,,,,West syndrome,,,,, -12436107,4232,,causes,,Corticotropin,,,,epilepsy,,,,, -11010111,4233,,causes,,Corticotropin,,,,rheumatoid arthritis,,,,, -17565428,4234,,affects,,Corticotropin,,,,West syndrome,,,,, -15783986,4235,,affects,,Corticotropin,,,,multiple sclerosis,,,,, -15695412,4236,,affects,,Corticotropin,,,,polycystic ovary syndrome,,,,, -11427275,4237,,affects,,Corticotropin,,,,dermatomyositis,,,,, -10737513,4238,,affects,,Corticotropin,,,,sarcoidosis,,,,, -10422766,4239,,affects,,Corticotropin,,,,rheumatoid arthritis,,,,, -9312832,4240,,affects,,Corticotropin,,,,epilepsy,,,,, -15159690,4241,,disrupts,,Corticotropin,,,,epilepsy,,,,, -27033387,4242,,prevents,,Corticotropin,,,,West syndrome,,,,, -10517176,4243,,prevents,,Corticotropin,,,,epilepsy,,,,, -23224982,4244,,predisposes,,Corticotropin,,,,epilepsy,,,,, -15800284,4245,,related to,,Dabigatran etexilate,,,,atrial fibrillation,,,,, -16972150,4246,,affects,,Dabigatran etexilate,,,,stroke disorder,,,,, -21262475,4247,,prevents,,Dabigatran etexilate,,,,thrombophilia due to thrombin defect,,,,, -19084221,4248,,prevents,,Dabigatran etexilate,,,,thrombotic disease,,,,, -14524874,4249,,prevents,,Dabigatran etexilate,,,,stroke disorder,,,,, -11599698,4250,,prevents,,Dabigatran etexilate,,,,Thromboembolism,,,,, -15929248,4251,,predisposes,,Dabigatran etexilate,,,,stroke disorder,,,,, -13343476,4252,,predisposes,,Dabigatran etexilate,,,,Thromboembolism,,,,, -10867084,4253,,related to,,Ximelagatran,,,,atrial fibrillation,,,,, -12162541,4254,,prevents,,Ximelagatran,,,,thrombotic disease,,,,, -9396435,4255,,prevents,,Ximelagatran,,,,Thromboembolism,,,,, -13148663,4256,,predisposes,,Ximelagatran,,,,Thromboembolism,,,,, -24220155,4257,,related to,,Bivalirudin,,,,Hemorrhage,,,,, -23845334,4258,,related to,,Bivalirudin,,,,thrombocytopenia,,,,, -21128552,4259,,related to,,Bivalirudin,,,,heart disorder,,,,, -16166302,4260,,related to,,Bivalirudin,,,,coronary artery disorder,,,,, -9469606,4261,,related to,,Bivalirudin,,,,myocardial infarction,,,,, -9060136,4262,,related to,,Bivalirudin,,,,acute coronary syndrome,,,,, -21743704,4263,,related to,,Bivalirudin,,,,Hemorrhage,,,,, -18003165,4264,,related to,,Bivalirudin,,,,thrombotic disease,,,,, -15575490,4265,,causes,,Bivalirudin,,,,myocardial infarction,,,,, -10298579,4266,,causes,,Bivalirudin,,,,Hemorrhage,,,,, -19056194,4267,,affects,,Bivalirudin,,,,thrombotic disease,,,,, -15575489,4268,,affects,,Bivalirudin,,,,thrombotic disease,,,,, -14748514,4269,,affects,,Bivalirudin,,,,myocardial infarction,,,,, -14318099,4270,,affects,,Bivalirudin,,,,Hemorrhage,,,,, -9597163,4271,,affects,,Bivalirudin,,,,Hemorrhage,,,,, -19316921,4272,,disrupts,,Bivalirudin,,,,myocardial infarction,,,,, -19056195,4273,,disrupts,,Bivalirudin,,,,thrombotic disease,,,,, -13525067,4274,,disrupts,,Bivalirudin,,,,acute coronary syndrome,,,,, -13434992,4275,,disrupts,,Bivalirudin,,,,Hemorrhage,,,,, -21793150,4276,,prevents,,Bivalirudin,,,,Hemorrhage,,,,, -20637086,4277,,prevents,,Bivalirudin,,,,syndromic disease,,,,, -17823880,4278,,prevents,,Bivalirudin,,,,myocardial infarction,,,,, -10215156,4279,,prevents,,Bivalirudin,,,,thrombotic disease,,,,, -22425248,4280,,predisposes,,Bivalirudin,,,,Hemorrhage,,,,, -16276306,4281,,predisposes,,Bivalirudin,,,,thrombotic disease,,,,, -14172527,4282,,predisposes,,Bivalirudin,,,,myocardial infarction,,,,, -17086386,4283,,disrupts,,Melagatran,,,,thrombotic disease,,,,, -9182682,4284,,related to,,Lepirudin,,,,thrombotic disease,,,,, -27183131,4285,,affects,,Lepirudin,,,,thrombotic disease,,,,, -26612130,4286,,disrupts,,Lepirudin,,,,thrombotic disease,,,,, -9038512,4287,,prevents,,Lepirudin,,,,thrombotic disease,,,,, -24074121,4288,,affects,,Ripasudil,,,,Fuchs' endothelial dystrophy,,,,, -23144840,4289,,prevents,,Netarsudil,,,,corneal edema,,,,, -21457868,4290,,prevents,,Netarsudil,,,,open-angle glaucoma,,,,, -25249408,4291,,related to,,Calcitriol,,,,Hypocalcemia,,,,, -24424216,4292,,related to,,Calcitriol,,,,Crohn disease,,,,, -23057137,4293,,related to,,Calcitriol,,,,acute kidney failure,,,,, -21048179,4294,,related to,,Calcitriol,,,,breast neoplasm,,,,, -18873537,4295,,related to,,Calcitriol,,,,diabetic kidney disease,,,,, -17759117,4296,,related to,,Calcitriol,,,,Sepsis,,,,, -17014883,4297,,related to,,Calcitriol,,,,hypoparathyroidism,,,,, -16783681,4298,,related to,,Calcitriol,,,,non-small cell lung carcinoma,,,,, -16670490,4299,,related to,,Calcitriol,,,,postmenopausal osteoporosis,,,,, -16084679,4300,,related to,,Calcitriol,,,,hypertensive disorder,,,,, -15183062,4301,,related to,,Calcitriol,,,,type 1 diabetes mellitus,,,,, -13574949,4302,,related to,,Calcitriol,,,,neoplasm,,,,, -13228040,4303,,related to,,Calcitriol,,,,castration-resistant prostate carcinoma,,,,, -11632117,4304,,related to,,Calcitriol,,,,prostate cancer,,,,, -11549262,4305,,related to,,Calcitriol,,,,renal osteodystrophy,,,,, -11138207,4306,,related to,,Calcitriol,,,,skin basal cell carcinoma,,,,, -9056874,4307,,related to,,Calcitriol,,,,psoriasis,,,,, -8335532,4308,,related to,,Calcitriol,,,,chronic kidney disease,,,,, -7638906,4309,,related to,,Calcitriol,,,,myelodysplastic syndrome,,,,, -7210521,4310,,related to,,Calcitriol,,,,osteoporosis,,,,, -23300761,4311,,causes,,Calcitriol,,,,hypoparathyroidism,,,,, -22190855,4312,,causes,,Calcitriol,,,,Hypocalcemia,,,,, -13672029,4313,,causes,,Calcitriol,,,,renal osteodystrophy,,,,, -8610431,4314,,causes,,Calcitriol,,,,neoplasm,,,,, -26699785,4315,,affects,,Calcitriol,,,,myelodysplastic syndrome,,,,, -26649101,4316,,affects,,Calcitriol,,,,psoriasis,,,,, -20118335,4317,,affects,,Calcitriol,,,,chronic kidney disease,,,,, -18144364,4318,,affects,,Calcitriol,,,,diabetic kidney disease,,,,, -17907580,4319,,affects,,Calcitriol,,,,breast neoplasm,,,,, -15840384,4320,,affects,,Calcitriol,,,,skin basal cell carcinoma,,,,, -15206874,4321,,affects,,Calcitriol,,,,neoplasm,,,,, -15145405,4322,,affects,,Calcitriol,,,,neoplasm,,,,, -10932246,4323,,affects,,Calcitriol,,,,chronic kidney disease,,,,, -9912093,4324,,affects,,Calcitriol,,,,prostate cancer,,,,, -9912091,4325,,affects,,Calcitriol,,,,prostate cancer,,,,, -26695789,4326,,produces,,Calcitriol,,,,renal osteodystrophy,,,,, -14288417,4327,,produces,,Calcitriol,,,,Crohn disease,,,,, -19013737,4328,,disrupts,,Calcitriol,,,,chronic kidney disease,,,,, -17492128,4329,,disrupts,,Calcitriol,,,,prostate cancer,,,,, -15711853,4330,,disrupts,,Calcitriol,,,,neoplasm,,,,, -23005720,4331,,prevents,,Calcitriol,,,,neoplasm,,,,, -22688863,4332,,prevents,,Calcitriol,,,,Hypocalcemia,,,,, -18398383,4333,,prevents,,Calcitriol,,,,diabetic kidney disease,,,,, -17492127,4334,,prevents,,Calcitriol,,,,prostate cancer,,,,, -8346486,4335,,prevents,,Calcitriol,,,,osteoporosis,,,,, -8053720,4336,,prevents,,Calcitriol,,,,postmenopausal osteoporosis,,,,, -24886178,4337,,exacerbates,,Calcitriol,,,,Sepsis,,,,, -18653087,4338,,exacerbates,,Calcitriol,,,,hypertensive disorder,,,,, -21373396,4339,,predisposes,,Calcitriol,,,,chronic kidney disease,,,,, -17377804,4340,,predisposes,,Calcitriol,,,,hypertensive disorder,,,,, -16828204,4341,,predisposes,,Calcitriol,,,,osteoporosis,,,,, -9760670,4342,,predisposes,,Calcitriol,,,,prostate cancer,,,,, -26462827,4343,,related to,,Alfacalcidol,,,,kidney failure,,,,, -9037270,4344,,related to,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, -7210524,4345,,related to,,Alfacalcidol,,,,osteoporosis,,,,, -22711685,4346,,causes,,Alfacalcidol,,,,osteoporosis,,,,, -26635675,4347,,affects,,Alfacalcidol,,,,kidney failure,,,,, -21927698,4348,,affects,,Alfacalcidol,,,,myopathy,,,,, -11900508,4349,,affects,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, -8505855,4350,,affects,,Alfacalcidol,,,,osteoporosis,,,,, -20641062,4351,,disrupts,,Alfacalcidol,,,,osteoporosis,,,,, -21927699,4352,,prevents,,Alfacalcidol,,,,myopathy,,,,, -7684744,4353,,prevents,,Alfacalcidol,,,,osteoporosis,,,,, -7684734,4354,,prevents,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, -24020567,4355,,related to,,Cholecalciferol,,,,male infertility,,,,, -23185349,4356,,related to,,Cholecalciferol,,,,ulcerative colitis,,,,, -22584995,4357,,related to,,Cholecalciferol,,,,acute myeloid leukemia,,,,, -21514930,4358,,related to,,Cholecalciferol,,,,Infection,,,,, -21254434,4359,,related to,,Cholecalciferol,,,,depressive disorder,,,,, -20389616,4360,,related to,,Cholecalciferol,,,,anemia,,,,, -20190699,4361,,related to,,Cholecalciferol,,,,autism spectrum disorder,,,,, -19639056,4362,,related to,,Cholecalciferol,,,,pulmonary tuberculosis,,,,, -18980881,4363,,related to,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, -18889413,4364,,related to,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, -18830431,4365,,related to,,Cholecalciferol,,,,prostate cancer,,,,, -18776998,4366,,related to,,Cholecalciferol,,,,epilepsy,,,,, -18009382,4367,,related to,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, -17581366,4368,,related to,,Cholecalciferol,,,,vitamin D deficiency,,,,, -17374616,4369,,related to,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, -17169513,4370,,related to,,Cholecalciferol,,,,Parkinson disease,,,,, -17054911,4371,,related to,,Cholecalciferol,,,,tuberculosis,,,,, -16909919,4372,,related to,,Cholecalciferol,,,,inflammatory bowel disease,,,,, -16219443,4373,,related to,,Cholecalciferol,,,,"dermatitis, atopic",,,,, -16115730,4374,,related to,,Cholecalciferol,,,,cardiovascular disorder,,,,, -15133291,4375,,related to,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -14512631,4376,,related to,,Cholecalciferol,,,,hyperparathyroidism,,,,, -13680137,4377,,related to,,Cholecalciferol,,,,multiple sclerosis,,,,, -13562951,4378,,related to,,Cholecalciferol,,,,metabolic syndrome X,,,,, -13562949,4379,,related to,,Cholecalciferol,,,,obesity disorder,,,,, -13035326,4380,,related to,,Cholecalciferol,,,,bone fracture,,,,, -11935565,4381,,related to,,Cholecalciferol,,,,osteoporosis,,,,, -11152529,4382,,related to,,Cholecalciferol,,,,diabetes mellitus,,,,, -10386853,4383,,related to,,Cholecalciferol,,,,Crohn disease,,,,, -9703967,4384,,related to,,Cholecalciferol,,,,melanoma,,,,, -9414232,4385,,related to,,Cholecalciferol,,,,psoriasis,,,,, -8798994,4386,,related to,,Cholecalciferol,,,,hip fracture,,,,, -20878953,4387,,causes,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, -20469671,4388,,causes,,Cholecalciferol,,,,tuberculosis,,,,, -20417553,4389,,causes,,Cholecalciferol,,,,psoriasis,,,,, -19411734,4390,,causes,,Cholecalciferol,,,,"dermatitis, atopic",,,,, -17854537,4391,,causes,,Cholecalciferol,,,,neoplasm,,,,, -15944158,4392,,causes,,Cholecalciferol,,,,vitamin D deficiency,,,,, -13998286,4393,,causes,,Cholecalciferol,,,,depressive disorder,,,,, -27560876,4394,,affects,,Cholecalciferol,,,,prostate cancer,,,,, -22640117,4395,,affects,,Cholecalciferol,,,,severe acute respiratory syndrome,,,,, -21843529,4396,,affects,,Cholecalciferol,,,,Pregnancy,,,,, -21703950,4397,,affects,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -20945952,4398,,affects,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, -20733345,4399,,affects,,Cholecalciferol,,,,epilepsy,,,,, -20612106,4400,,affects,,Cholecalciferol,,,,Cognitive impairment,,,,, -19925618,4401,,affects,,Cholecalciferol,,,,asthma,,,,, -19815601,4402,,affects,,Cholecalciferol,,,,ulcerative colitis,,,,, -19556148,4403,,affects,,Cholecalciferol,,,,neoplasm,,,,, -19132727,4404,,affects,,Cholecalciferol,,,,obesity disorder,,,,, -18122364,4405,,affects,,Cholecalciferol,,,,metabolic syndrome X,,,,, -18122363,4406,,affects,,Cholecalciferol,,,,cardiovascular disorder,,,,, -17715748,4407,,affects,,Cholecalciferol,,,,hip fracture,,,,, -17674517,4408,,affects,,Cholecalciferol,,,,Pregnancy,,,,, -17585577,4409,,affects,,Cholecalciferol,,,,depressive disorder,,,,, -17451551,4410,,affects,,Cholecalciferol,,,,neoplasm,,,,, -16299943,4411,,affects,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, -16007821,4412,,affects,,Cholecalciferol,,,,psoriasis,,,,, -15977971,4413,,affects,,Cholecalciferol,,,,melanoma,,,,, -15944152,4414,,affects,,Cholecalciferol,,,,osteoporosis,,,,, -15393278,4415,,affects,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, -15170889,4416,,affects,,Cholecalciferol,,,,multiple sclerosis,,,,, -13518388,4417,,affects,,Cholecalciferol,,,,bone fracture,,,,, -21045274,4418,,produces,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -17840044,4419,,produces,,Cholecalciferol,,,,inflammatory bowel disease,,,,, -20733344,4420,,disrupts,,Cholecalciferol,,,,epilepsy,,,,, -19044664,4421,,disrupts,,Cholecalciferol,,,,AIDS,,,,, -15558469,4422,,disrupts,,Cholecalciferol,,,,HIV infectious disease,,,,, -14834931,4423,,disrupts,,Cholecalciferol,,,,neoplasm,,,,, -14617748,4424,,disrupts,,Cholecalciferol,,,,multiple sclerosis,,,,, -14491908,4425,,disrupts,,Cholecalciferol,,,,vitamin D deficiency,,,,, -11194374,4426,,disrupts,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -25419746,4427,,prevents,,Cholecalciferol,,,,Infection,,,,, -23552226,4428,,prevents,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, -23324302,4429,,prevents,,Cholecalciferol,,,,ulcerative colitis,,,,, -22418643,4430,,prevents,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, -22340834,4431,,prevents,,Cholecalciferol,,,,depressive disorder,,,,, -20959064,4432,,prevents,,Cholecalciferol,,,,postmenopausal osteoporosis,,,,, -20699168,4433,,prevents,,Cholecalciferol,,,,cardiovascular disorder,,,,, -19389521,4434,,prevents,,Cholecalciferol,,,,epilepsy,,,,, -18282049,4435,,prevents,,Cholecalciferol,,,,inherited lipid metabolism disorder,,,,, -17951280,4436,,prevents,,Cholecalciferol,,,,anemia,,,,, -17701830,4437,,prevents,,Cholecalciferol,,,,influenza,,,,, -15773595,4438,,prevents,,Cholecalciferol,,,,neoplasm,,,,, -15663430,4439,,prevents,,Cholecalciferol,,,,diabetes mellitus,,,,, -12943427,4440,,prevents,,Cholecalciferol,,,,vitamin D deficiency,,,,, -11194373,4441,,prevents,,Cholecalciferol,,,,osteoporosis,,,,, -11017561,4442,,prevents,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -10503621,4443,,prevents,,Cholecalciferol,,,,bone fracture,,,,, -9458588,4444,,prevents,,Cholecalciferol,,,,hip fracture,,,,, -21072124,4445,,predisposes,,Cholecalciferol,,,,metabolic syndrome X,,,,, -18104348,4446,,predisposes,,Cholecalciferol,,,,colorectal neoplasm,,,,, -17901013,4447,,predisposes,,Cholecalciferol,,,,bone fracture,,,,, -17714481,4448,,predisposes,,Cholecalciferol,,,,asthma,,,,, -17184810,4449,,predisposes,,Cholecalciferol,,,,multiple sclerosis,,,,, -15110409,4450,,predisposes,,Cholecalciferol,,,,vitamin D deficiency,,,,, -13562954,4451,,predisposes,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, -9524358,4452,,predisposes,,Cholecalciferol,,,,hip fracture,,,,, -9314384,4453,,predisposes,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, -27330803,4454,,related to,,Ergocalciferol,,,,Familial hypophosphatemia,,,,, -26089502,4455,,related to,,Ergocalciferol,,,,osteogenesis imperfecta,,,,, -22199149,4456,,related to,,Ergocalciferol,,,,Hypocalcemia,,,,, -22194600,4457,,related to,,Ergocalciferol,,,,severe acute respiratory syndrome,,,,, -21840711,4458,,related to,,Ergocalciferol,,,,castration-resistant prostate carcinoma,,,,, -21543726,4459,,related to,,Ergocalciferol,,,,sarcopenia,,,,, -21516783,4460,,related to,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, -21478252,4461,,related to,,Ergocalciferol,,,,bone fracture,,,,, -21128214,4462,,related to,,Ergocalciferol,,,,bone Paget disease,,,,, -20256197,4463,,related to,,Ergocalciferol,,,,restless legs syndrome,,,,, -19853448,4464,,related to,,Ergocalciferol,,,,neuralgia,,,,, -19595978,4465,,related to,,Ergocalciferol,,,,hepatitis C virus infection,,,,, -19221334,4466,,related to,,Ergocalciferol,,,,spinal cord injury,,,,, -18303138,4467,,related to,,Ergocalciferol,,,,optic neuritis,,,,, -17457750,4468,,related to,,Ergocalciferol,,,,migraine disorder,,,,, -17248671,4469,,related to,,Ergocalciferol,,,,diffuse alopecia areata,,,,, -16231683,4470,,related to,,Ergocalciferol,,,,chronic hepatitis C virus infection,,,,, -16050991,4471,,related to,,Ergocalciferol,,,,lung neoplasm,,,,, -15954794,4472,,related to,,Ergocalciferol,,,,femoral neck fracture,,,,, -15739454,4473,,related to,,Ergocalciferol,,,,diabetic neuropathy,,,,, -15603622,4474,,related to,,Ergocalciferol,,,,HIV infectious disease,,,,, -15306422,4475,,related to,,Ergocalciferol,,,,blood coagulation disease,,,,, -15165807,4476,,related to,,Ergocalciferol,,,,postmenopausal osteoporosis,,,,, -14949967,4477,,related to,,Ergocalciferol,,,,Premature birth,,,,, -14949966,4478,,related to,,Ergocalciferol,,,,gestational diabetes,,,,, -14870236,4479,,related to,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, -14594285,4480,,related to,,Ergocalciferol,,,,colorectal neoplasm,,,,, -14321159,4481,,related to,,Ergocalciferol,,,,asthma,,,,, -13975664,4482,,related to,,Ergocalciferol,,,,cutaneous lupus erythematosus,,,,, -13939480,4483,,related to,,Ergocalciferol,,,,mood disorder,,,,, -13895667,4484,,related to,,Ergocalciferol,,,,sudden cardiac arrest,,,,, -13383363,4485,,related to,,Ergocalciferol,,,,sickle cell anemia,,,,, -13199782,4486,,related to,,Ergocalciferol,,,,Alzheimer disease,,,,, -12834035,4487,,related to,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -12803681,4488,,related to,,Ergocalciferol,,,,Insulin resistance,,,,, -12377378,4489,,related to,,Ergocalciferol,,,,non-Hodgkin lymphoma,,,,, -12131992,4490,,related to,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -11979233,4491,,related to,,Ergocalciferol,,,,leukemia,,,,, -11933002,4492,,related to,,Ergocalciferol,,,,Pain,,,,, -11653558,4493,,related to,,Ergocalciferol,,,,melanoma,,,,, -11434397,4494,,related to,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -11002964,4495,,related to,,Ergocalciferol,,,,pulmonary tuberculosis,,,,, -10894479,4496,,related to,,Ergocalciferol,,,,Crohn disease,,,,, -10768947,4497,,related to,,Ergocalciferol,,,,hip fracture,,,,, -10183383,4498,,related to,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -10168534,4499,,related to,,Ergocalciferol,,,,tuberculosis,,,,, -10066878,4500,,related to,,Ergocalciferol,,,,lymphoma,,,,, -9770434,4501,,related to,,Ergocalciferol,,,,neoplasm,,,,, -9499640,4502,,related to,,Ergocalciferol,,,,hypoparathyroidism,,,,, -9487308,4503,,related to,,Ergocalciferol,,,,myocardial ischemia,,,,, -9462983,4504,,related to,,Ergocalciferol,,,,ulcerative colitis,,,,, -9176947,4505,,related to,,Ergocalciferol,,,,psoriasis,,,,, -9137351,4506,,related to,,Ergocalciferol,,,,nutritional disorder,,,,, -8792180,4507,,related to,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -8116213,4508,,related to,,Ergocalciferol,,,,obesity disorder,,,,, -8093753,4509,,related to,,Ergocalciferol,,,,vitamin D deficiency,,,,, -8061037,4510,,related to,,Ergocalciferol,,,,multiple sclerosis,,,,, -8061036,4511,,related to,,Ergocalciferol,,,,diabetes mellitus,,,,, -7613246,4512,,related to,,Ergocalciferol,,,,osteoporosis,,,,, -7587226,4513,,related to,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, -7252642,4514,,related to,,Ergocalciferol,,,,prostate cancer,,,,, -26403196,4515,,causes,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -25624374,4516,,causes,,Ergocalciferol,,,,leukemia,,,,, -25513025,4517,,causes,,Ergocalciferol,,,,restless legs syndrome,,,,, -25147512,4518,,causes,,Ergocalciferol,,,,sarcopenia,,,,, -21420546,4519,,causes,,Ergocalciferol,,,,diabetic neuropathy,,,,, -21344725,4520,,causes,,Ergocalciferol,,,,diffuse alopecia areata,,,,, -19221130,4521,,causes,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, -19022139,4522,,causes,,Ergocalciferol,,,,gestational diabetes,,,,, -18967408,4523,,causes,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, -18875338,4524,,causes,,Ergocalciferol,,,,psoriasis,,,,, -18041148,4525,,causes,,Ergocalciferol,,,,Crohn disease,,,,, -16369420,4526,,causes,,Ergocalciferol,,,,neoplasm,,,,, -16017645,4527,,causes,,Ergocalciferol,,,,obesity disorder,,,,, -15862130,4528,,causes,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -15179909,4529,,causes,,Ergocalciferol,,,,asthma,,,,, -14594790,4530,,causes,,Ergocalciferol,,,,Insulin resistance,,,,, -14004176,4531,,causes,,Ergocalciferol,,,,Pain,,,,, -12191251,4532,,causes,,Ergocalciferol,,,,osteoporosis,,,,, -11612180,4533,,causes,,Ergocalciferol,,,,colorectal neoplasm,,,,, -11557471,4534,,causes,,Ergocalciferol,,,,vitamin D deficiency,,,,, -11557464,4535,,causes,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -11275618,4536,,causes,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -10362733,4537,,causes,,Ergocalciferol,,,,multiple sclerosis,,,,, -8719466,4538,,causes,,Ergocalciferol,,,,diabetes mellitus,,,,, -8407906,4539,,causes,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -7553325,4540,,causes,,Ergocalciferol,,,,prostate cancer,,,,, -7357695,4541,,causes,,Ergocalciferol,,,,bone fracture,,,,, -25936029,4542,,affects,,Ergocalciferol,,,,nutritional disorder,,,,, -25430100,4543,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -24682916,4544,,affects,,Ergocalciferol,,,,bone fracture,,,,, -24133915,4545,,affects,,Ergocalciferol,,,,HIV infectious disease,,,,, -23716846,4546,,affects,,Ergocalciferol,,,,Premature birth,,,,, -22436428,4547,,affects,,Ergocalciferol,,,,obesity disorder,,,,, -22382447,4548,,affects,,Ergocalciferol,,,,Pregnancy,,,,, -21132793,4549,,affects,,Ergocalciferol,,,,breast neoplasm,,,,, -20959246,4550,,affects,,Ergocalciferol,,,,diabetes mellitus,,,,, -20298561,4551,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -20058982,4552,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, -19907316,4553,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, -19815602,4554,,affects,,Ergocalciferol,,,,ulcerative colitis,,,,, -19320344,4555,,affects,,Ergocalciferol,,,,Premature birth,,,,, -19221129,4556,,affects,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, -18424308,4557,,affects,,Ergocalciferol,,,,vitamin D deficiency,,,,, -18115621,4558,,affects,,Ergocalciferol,,,,asthma,,,,, -17654393,4559,,affects,,Ergocalciferol,,,,optic neuritis,,,,, -17646826,4560,,affects,,Ergocalciferol,,,,migraine disorder,,,,, -17581908,4561,,affects,,Ergocalciferol,,,,Pain,,,,, -17056932,4562,,affects,,Ergocalciferol,,,,sarcopenia,,,,, -16630786,4563,,affects,,Ergocalciferol,,,,sarcopenia,,,,, -16542255,4564,,affects,,Ergocalciferol,,,,melanoma,,,,, -16343274,4565,,affects,,Ergocalciferol,,,,restless legs syndrome,,,,, -16273798,4566,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, -16273796,4567,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -15812657,4568,,affects,,Ergocalciferol,,,,prostate cancer,,,,, -15750325,4569,,affects,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, -15694248,4570,,affects,,Ergocalciferol,,,,mood disorder,,,,, -15543952,4571,,affects,,Ergocalciferol,,,,osteoporosis,,,,, -15528071,4572,,affects,,Ergocalciferol,,,,Alzheimer disease,,,,, -15258155,4573,,affects,,Ergocalciferol,,,,obesity disorder,,,,, -14609756,4574,,affects,,Ergocalciferol,,,,tuberculosis,,,,, -14384550,4575,,affects,,Ergocalciferol,,,,psoriasis,,,,, -14233188,4576,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, -13916047,4577,,affects,,Ergocalciferol,,,,hip fracture,,,,, -13794313,4578,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, -13764162,4579,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, -13437693,4580,,affects,,Ergocalciferol,,,,Crohn disease,,,,, -13211992,4581,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -13015298,4582,,affects,,Ergocalciferol,,,,asthma,,,,, -12698804,4583,,affects,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, -12502345,4584,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, -12032067,4585,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, -11831475,4586,,affects,,Ergocalciferol,,,,bone fracture,,,,, -10991167,4587,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, -10917919,4588,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, -10608353,4589,,affects,,Ergocalciferol,,,,Pregnancy,,,,, -8987937,4590,,affects,,Ergocalciferol,,,,hip fracture,,,,, -8925552,4591,,affects,,Ergocalciferol,,,,prostate cancer,,,,, -8894668,4592,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -8321224,4593,,affects,,Ergocalciferol,,,,neoplasm,,,,, -7878820,4594,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, -21952380,4595,,produces,,Ergocalciferol,,,,obesity disorder,,,,, -21636964,4596,,produces,,Ergocalciferol,,,,asthma,,,,, -20636497,4597,,produces,,Ergocalciferol,,,,Pregnancy,,,,, -20444810,4598,,produces,,Ergocalciferol,,,,Alzheimer disease,,,,, -15318015,4599,,produces,,Ergocalciferol,,,,melanoma,,,,, -14384547,4600,,produces,,Ergocalciferol,,,,psoriasis,,,,, +23573980,501,,related to,,Methylprednisolone,,,,pneumonia,,,,, +23514846,502,,related to,,Methylprednisolone,,,,carpal tunnel syndrome,,,,, +23364897,503,,related to,,Methylprednisolone,,,,West syndrome,,,,, +22495910,504,,related to,,Methylprednisolone,,,,myocarditis,,,,, +22175056,505,,related to,,Methylprednisolone,,,,myopathy,,,,, +20879022,506,,related to,,Methylprednisolone,,,,Pain,,,,, +20342058,507,,related to,,Methylprednisolone,,,,chronic progressive multiple sclerosis,,,,, +20290784,508,,related to,,Methylprednisolone,,,,membranous glomerulonephritis,,,,, +20286711,509,,related to,,Methylprednisolone,,,,neuromyelitis optica,,,,, +19340184,510,,related to,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, +18938435,511,,related to,,Methylprednisolone,,,,graft versus host disease,,,,, +17333962,512,,related to,,Methylprednisolone,,,,Inflammation,,,,, +17288506,513,,related to,,Methylprednisolone,,,,autoimmune thrombocytopenic purpura,,,,, +15936572,514,,related to,,Methylprednisolone,,,,endocrine exophthalmos,,,,, +15072844,515,,related to,,Methylprednisolone,,,,Edema,,,,, +14876749,516,,related to,,Methylprednisolone,,,,osteoarthritis,,,,, +14399082,517,,related to,,Methylprednisolone,,,,aplastic anemia,,,,, +14398237,518,,related to,,Methylprednisolone,,,,IgA glomerulonephritis,,,,, +14278238,519,,related to,,Methylprednisolone,,,,"dermatitis, atopic",,,,, +14166179,520,,related to,,Methylprednisolone,,,,cardiac arrest,,,,, +12755316,521,,related to,,Methylprednisolone,,,,plasma cell myeloma,,,,, +12183687,522,,related to,,Methylprednisolone,,,,acute lymphoblastic leukemia,,,,, +11720471,523,,related to,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, +10812685,524,,related to,,Methylprednisolone,,,,immunoglobulin a vasculitis,,,,, +10763477,525,,related to,,Methylprednisolone,,,,ulcerative colitis,,,,, +10558884,526,,related to,,Methylprednisolone,,,,lupus nephritis,,,,, +10130342,527,,related to,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, +9229208,528,,related to,,Methylprednisolone,,,,vestibular neuronitis,,,,, +9003326,529,,related to,,Methylprednisolone,,,,systemic sclerosis,,,,, +8447481,530,,related to,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +8282330,531,,related to,,Methylprednisolone,,,,spinal cord injury,,,,, +7944646,532,,related to,,Methylprednisolone,,,,myasthenia gravis,,,,, +7668599,533,,related to,,Methylprednisolone,,,,multiple sclerosis,,,,, +7443745,534,,related to,,Methylprednisolone,,,,asthma,,,,, +24973247,535,,causes,,Methylprednisolone,,,,lupus nephritis,,,,, +24161886,536,,causes,,Methylprednisolone,,,,Edema,,,,, +18534953,537,,causes,,Methylprednisolone,,,,Inflammation,,,,, +18260665,538,,causes,,Methylprednisolone,,,,neoplasm,,,,, +17307095,539,,causes,,Methylprednisolone,,,,pneumonia,,,,, +15906641,540,,causes,,Methylprednisolone,,,,Pain,,,,, +13166073,541,,causes,,Methylprednisolone,,,,thrombocytopenia,,,,, +12672767,542,,causes,,Methylprednisolone,,,,drug-induced liver injury,,,,, +8525599,543,,causes,,Methylprednisolone,,,,myopathy,,,,, +27357949,544,,affects,,Methylprednisolone,,,,neoplasm,,,,, +24420470,545,,affects,,Methylprednisolone,,,,Inflammation,,,,, +23472756,546,,affects,,Methylprednisolone,,,,Inflammation,,,,, +20530617,547,,affects,,Methylprednisolone,,,,systemic sclerosis,,,,, +20254789,548,,affects,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, +17649050,549,,affects,,Methylprednisolone,,,,optic nerve disorder,,,,, +16634377,550,,affects,,Methylprednisolone,,,,myasthenia gravis,,,,, +16277488,551,,affects,,Methylprednisolone,,,,neuromyelitis optica,,,,, +15906642,552,,affects,,Methylprednisolone,,,,Pain,,,,, +15610554,553,,affects,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +15186368,554,,affects,,Methylprednisolone,,,,graft versus host disease,,,,, +14891106,555,,affects,,Methylprednisolone,,,,kidney disorder,,,,, +11819955,556,,affects,,Methylprednisolone,,,,spinal cord injury,,,,, +10845505,557,,affects,,Methylprednisolone,,,,Pain,,,,, +10048898,558,,affects,,Methylprednisolone,,,,ulcerative colitis,,,,, +9646753,559,,affects,,Methylprednisolone,,,,multiple sclerosis,,,,, +9346353,560,,affects,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, +9107378,561,,affects,,Methylprednisolone,,,,Edema,,,,, +8596544,562,,affects,,Methylprednisolone,,,,asthma,,,,, +8330909,563,,affects,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, +19744632,564,,disrupts,,Methylprednisolone,,,,Edema,,,,, +18407557,565,,disrupts,,Methylprednisolone,,,,thrombocytopenia,,,,, +11106658,566,,disrupts,,Methylprednisolone,,,,Pain,,,,, +8640603,567,,disrupts,,Methylprednisolone,,,,Inflammation,,,,, +23934495,568,,prevents,,Methylprednisolone,,,,Cognitive impairment,,,,, +20014108,569,,prevents,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +18266414,570,,prevents,,Methylprednisolone,,,,Abdominal pain,,,,, +14967074,571,,prevents,,Methylprednisolone,,,,asthma,,,,, +9744990,572,,prevents,,Methylprednisolone,,,,ovarian hyperstimulation syndrome,,,,, +8345063,573,,prevents,,Methylprednisolone,,,,Pain,,,,, +8291272,574,,prevents,,Methylprednisolone,,,,graft versus host disease,,,,, +7980138,575,,prevents,,Methylprednisolone,,,,spinal cord injury,,,,, +7414405,576,,prevents,,Methylprednisolone,,,,Edema,,,,, +18106042,577,,predisposes,,Methylprednisolone,,,,pneumonia,,,,, +9645180,578,,predisposes,,Methylprednisolone,,,,Inflammation,,,,, +12905337,579,,related to,,Cefotaxime,,,,Sepsis,,,,, +24475300,580,,affects,,Cefotaxime,,,,bacterial infectious disease,,,,, +23922029,581,,affects,,Cefotaxime,,,,Sepsis,,,,, +18672205,582,,affects,,Cefotaxime,,,,peritonitis,,,,, +15853591,583,,prevents,,Cefotaxime,,,,Sepsis,,,,, +19081412,584,,prevents,,Ceftriaxone,,,,bacterial infectious disease,,,,, +25827448,585,,related to,,Gefarnate,,,,gastric ulcer,,,,, +24296137,586,,related to,,Gefarnate,,,,duodenal ulcer,,,,, +25993651,587,,disrupts,,Gefarnate,,,,gastric ulcer,,,,, +17758516,588,,related to,,Neobiotic,,,,Inflammation,,,,, +10690423,589,,related to,,Neobiotic,,,,burn,,,,, +20263460,590,,affects,,Neobiotic,,,,neoplasm,,,,, +19744068,591,,affects,,Neobiotic,,,,Inflammation,,,,, +24669492,592,,disrupts,,Neobiotic,,,,bacterial infectious disease,,,,, +17119153,593,,disrupts,,Neobiotic,,,,neoplasm,,,,, +26428369,594,,prevents,,Neobiotic,,,,bacterial infectious disease,,,,, +25579460,595,,related to,,BLINATUMOMAB,,,,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,,,,, +22474123,596,,related to,,BLINATUMOMAB,,,,hematopoietic and lymphoid system neoplasm,,,,, +21947892,597,,related to,,BLINATUMOMAB,,,,acute lymphoblastic leukemia,,,,, +27155094,598,,related to,,Ciprofloxacin,,,,endophthalmitis,,,,, +16836665,599,,related to,,Ciprofloxacin,,,,Crohn disease,,,,, +19572117,600,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, +19572117,601,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, +12385742,602,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +12385742,603,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +17007621,604,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +17007621,605,,coexists with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +9387116,606,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +8212496,607,,physically interacts with,,Ciprofloxacin,,,,DNA Gyrase,,,,, +25648466,608,,causes,,Ciprofloxacin,,,,abscess,,,,, +24716241,609,,causes,,Ciprofloxacin,,,,peritonitis,,,,, +17154464,610,,causes,,Ciprofloxacin,,,,prostatitis,,,,, +14369807,611,,causes,,Ciprofloxacin,,,,neutropenia,,,,, +13950319,612,,causes,,Ciprofloxacin,,,,pneumonia,,,,, +10209213,613,,causes,,Ciprofloxacin,,,,infectious disease,,,,, +7113733,614,,causes,,Ciprofloxacin,,,,osteomyelitis,,,,, +21996198,615,,affects,,Ciprofloxacin,,,,infectious disease,,,,, +16563368,616,,affects,,Ciprofloxacin,,,,Fever,,,,, +16125923,617,,affects,,Ciprofloxacin,,,,osteomyelitis,,,,, +12942741,618,,affects,,Ciprofloxacin,,,,Crohn disease,,,,, +11440816,619,,affects,,Ciprofloxacin,,,,typhoid fever,,,,, +11267024,620,,affects,,Ciprofloxacin,,,,eye infectious disorder,,,,, +10672042,621,,affects,,Ciprofloxacin,,,,Abdominal Infection,,,,, +9891814,622,,affects,,Ciprofloxacin,,,,pneumonia,,,,, +9122989,623,,affects,,Ciprofloxacin,,,,infectious disease,,,,, +8956826,624,,affects,,Ciprofloxacin,,,,Pseudomonas infection,,,,, +8956825,625,,affects,,Ciprofloxacin,,,,cystic fibrosis,,,,, +8669720,626,,affects,,Ciprofloxacin,,,,Fever,,,,, +7886704,627,,affects,,Ciprofloxacin,,,,bronchiectasis,,,,, +7886701,628,,affects,,Ciprofloxacin,,,,chronic bronchitis,,,,, +7781719,629,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, +7592205,630,,affects,,Ciprofloxacin,,,,chronic obstructive pulmonary disease,,,,, +18400322,631,,affects,,Ciprofloxacin,,,,DNA Gyrase,,,,, +26984478,632,,disrupts,,Ciprofloxacin,,,,Fever,,,,, +26466958,633,,disrupts,,Ciprofloxacin,,,,pneumonia,,,,, +18480207,634,,disrupts,,Ciprofloxacin,,,,infectious disease,,,,, +10323767,635,,disrupts,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, +27242944,636,,prevents,,Ciprofloxacin,,,,pyelonephritis,,,,, +21807033,637,,prevents,,Ciprofloxacin,,,,Infection,,,,, +16138544,638,,prevents,,Ciprofloxacin,,,,diarrheal disease,,,,, +15438014,639,,prevents,,Ciprofloxacin,,,,Sepsis,,,,, +14202377,640,,prevents,,Ciprofloxacin,,,,plague,,,,, +12292532,641,,prevents,,Ciprofloxacin,,,,endophthalmitis,,,,, +10767980,642,,prevents,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, +9947057,643,,prevents,,Ciprofloxacin,,,,bacterial infectious disease,,,,, +8364719,644,,prevents,,Ciprofloxacin,,,,pneumonia,,,,, +8054296,645,,prevents,,Ciprofloxacin,,,,infectious disease,,,,, +18366035,646,,predisposes,,Ciprofloxacin,,,,infectious disease,,,,, +15459841,647,,predisposes,,Ciprofloxacin,,,,bacterial infectious disease with sepsis,,,,, +8758764,648,,predisposes,,Ciprofloxacin,,,,gonorrhea,,,,, +15493028,649,,disrupts,,Chloramphenicol,,,,acne,,,,, +21241586,650,,prevents,,Chloramphenicol,,,,eye infectious disorder,,,,, +16722213,651,,causes,,Rebamipide,,,,osteoarthritis,,,,, +27679650,652,,affects,,Rebamipide,,,,peptic ulcer disease,,,,, +10125846,653,,affects,,Rebamipide,,,,gastric ulcer,,,,, +16923576,654,,disrupts,,Rebamipide,,,,gastritis,,,,, +20953135,655,,prevents,,Rebamipide,,,,peptic ulcer disease,,,,, +13727344,656,,prevents,,Rebamipide,,,,gastritis,,,,, +10452606,657,,prevents,,Rebamipide,,,,gastric ulcer,,,,, +23020953,658,,related to,,DINUTUXIMAB,,,,neoplasm,,,,, +12385638,659,,related to,,DINUTUXIMAB,,,,neuroblastoma,,,,, +21974466,660,,causes,,DINUTUXIMAB,,,,neuroblastoma,,,,, +23929422,661,,related to,,BRENTUXIMAB VEDOTIN,,,,anaplastic large cell lymphoma,,,,, +23730531,662,,related to,,BRENTUXIMAB VEDOTIN,,,,mycosis fungoides,,,,, +23653011,663,,related to,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, +23065539,664,,related to,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, +21812241,665,,related to,,BRENTUXIMAB VEDOTIN,,,,Hodgkins lymphoma,,,,, +21657994,666,,related to,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +21657993,667,,related to,,BRENTUXIMAB VEDOTIN,,,,primary cutaneous T-cell non-Hodgkin lymphoma,,,,, +22071488,668,,has part,,BRENTUXIMAB VEDOTIN,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +21553377,669,,has part,,BRENTUXIMAB VEDOTIN,,,,diffuse large B-cell lymphoma,,,,, +23435913,670,,affects,,BRENTUXIMAB VEDOTIN,,,,lymphoma,,,,, +20170701,671,,causes,,Tetracycline,,,,periodontitis,,,,, +19472933,672,,causes,,Tetracycline,,,,Helicobacter pylori infectious disease,,,,, +18080767,673,,affects,,Tetracycline,,,,periodontitis,,,,, +17969405,674,,affects,,Tetracycline,,,,bacterial infectious disease,,,,, +24565223,675,,prevents,,Tetracycline,,,,bacterial infectious disease,,,,, +10847016,676,,prevents,,Tetracycline,,,,inclusion conjunctivitis,,,,, +12376615,677,,related to,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +11754791,678,,related to,,(Alginate)n,,,,cystic fibrosis,,,,, +10599430,679,,related to,,(Alginate)n,,,,obesity disorder,,,,, +27435796,680,,affects,,(Alginate)n,,,,cystic fibrosis,,,,, +27132270,681,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +23415127,682,,affects,,(Alginate)n,,,,obesity disorder,,,,, +19854419,683,,affects,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +8246131,684,,disrupts,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +11492096,685,,prevents,,(Alginate)n,,,,gastroesophageal reflux disease,,,,, +23508922,686,,predisposes,,(Alginate)n,,,,obesity disorder,,,,, +11597598,687,,related to,,Zolimidine,,,,peptic ulcer disease,,,,, +20742970,688,,causes,,Chlorhexidine,,,,infectious disease,,,,, +16147932,689,,causes,,Chlorhexidine,,,,gingivitis,,,,, +15413413,690,,causes,,Chlorhexidine,,,,stomatitis,,,,, +13735208,691,,causes,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, +23793676,692,,affects,,Chlorhexidine,,,,Infection,,,,, +21319017,693,,affects,,Chlorhexidine,,,,pneumonia,,,,, +20585434,694,,affects,,Chlorhexidine,,,,stomatitis,,,,, +13503760,695,,affects,,Chlorhexidine,,,,periodontal disorder,,,,, +8506996,696,,affects,,Chlorhexidine,,,,gingivitis,,,,, +25489531,697,,disrupts,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, +22304373,698,,disrupts,,Chlorhexidine,,,,dental caries,,,,, +21939464,699,,disrupts,,Chlorhexidine,,,,Infection,,,,, +19793680,700,,disrupts,,Chlorhexidine,,,,bacterial infectious disease,,,,, +18040358,701,,disrupts,,Chlorhexidine,,,,infectious disease,,,,, +11272633,702,,disrupts,,Chlorhexidine,,,,gingivitis,,,,, +26042520,703,,prevents,,Chlorhexidine,,,,staphylococcal infection,,,,, +22617089,704,,prevents,,Chlorhexidine,,,,periodontitis,,,,, +22038778,705,,prevents,,Chlorhexidine,,,,bacterial infectious disease,,,,, +22000060,706,,prevents,,Chlorhexidine,,,,Infection,,,,, +21737487,707,,prevents,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, +19905103,708,,prevents,,Chlorhexidine,,,,periodontal disorder,,,,, +16765643,709,,prevents,,Chlorhexidine,,,,Neonatal sepsis,,,,, +14052320,710,,prevents,,Chlorhexidine,,,,pneumonia,,,,, +11830955,711,,prevents,,Chlorhexidine,,,,bacterial infectious disease with sepsis,,,,, +11145796,712,,prevents,,Chlorhexidine,,,,infectious disease,,,,, +10739867,713,,prevents,,Chlorhexidine,,,,stomatitis,,,,, +10141569,714,,prevents,,Chlorhexidine,,,,dental caries,,,,, +7990742,715,,prevents,,Chlorhexidine,,,,gingivitis,,,,, +23454202,716,,predisposes,,Chlorhexidine,,,,"Pneumonia, Ventilator-Associated",,,,, +19942414,717,,predisposes,,Chlorhexidine,,,,periodontal disorder,,,,, +18735040,718,,predisposes,,Chlorhexidine,,,,dental caries,,,,, +16765642,719,,predisposes,,Chlorhexidine,,,,Neonatal sepsis,,,,, +24905090,720,,causes,,Nicergoline,,,,depressive disorder,,,,, +25103280,721,,related to,,RAMUCIRUMAB,,,,hepatocellular carcinoma,,,,, +22612331,722,,related to,,RAMUCIRUMAB,,,,neoplasm,,,,, +21600131,723,,related to,,RAMUCIRUMAB,,,,non-small cell lung carcinoma,,,,, +22008312,724,,affects,,RAMUCIRUMAB,,,,neoplasm,,,,, +23569571,725,,related to,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, +24533103,726,,disrupts,,TAFASITAMAB,,,,diffuse large B-cell lymphoma,,,,, +21884997,727,,related to,,Thioctic acid,,,,cystinuria,,,,, +20207321,728,,related to,,Thioctic acid,,,,chronic progressive multiple sclerosis,,,,, +18115881,729,,related to,,Thioctic acid,,,,hypertensive disorder,,,,, +15406106,730,,related to,,Thioctic acid,,,,optic neuritis,,,,, +12204809,731,,related to,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, +11741203,732,,related to,,Thioctic acid,,,,multiple sclerosis,,,,, +11010945,733,,related to,,Thioctic acid,,,,AIDS,,,,, +10648973,734,,related to,,Thioctic acid,,,,skin disorder,,,,, +7603472,735,,related to,,Thioctic acid,,,,diabetic neuropathy,,,,, +16842192,736,,causes,,Thioctic acid,,,,hypertensive disorder,,,,, +21111426,737,,affects,,Thioctic acid,,,,optic neuritis,,,,, +18505755,738,,affects,,Thioctic acid,,,,diabetic neuropathy,,,,, +17198477,739,,affects,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, +12393284,740,,affects,,Thioctic acid,,,,Alzheimer disease,,,,, +9028391,741,,affects,,Thioctic acid,,,,hypertensive disorder,,,,, +21111429,742,,prevents,,Thioctic acid,,,,optic neuritis,,,,, +18775341,743,,prevents,,Thioctic acid,,,,skin disorder,,,,, +18076378,744,,prevents,,Thioctic acid,,,,type 2 diabetes mellitus,,,,, +15377554,745,,prevents,,Thioctic acid,,,,stroke disorder,,,,, +13878249,746,,prevents,,Thioctic acid,,,,Alzheimer disease,,,,, +8826102,747,,prevents,,Thioctic acid,,,,hypertensive disorder,,,,, +8682086,748,,prevents,,Thioctic acid,,,,diabetic neuropathy,,,,, +15385084,749,,predisposes,,Thioctic acid,,,,Alzheimer disease,,,,, +26276598,750,,related to,,Ampicillin,,,,Sepsis,,,,, +19644222,751,,related to,,Ampicillin,,,,pneumonia,,,,, +27702232,752,,causes,,Ampicillin,,,,Sepsis,,,,, +15854005,753,,causes,,Ampicillin,,,,pneumonia,,,,, +14938843,754,,affects,,Ampicillin,,,,Sepsis,,,,, +8930713,755,,affects,,Ampicillin,,,,gonorrhea,,,,, +21012437,756,,disrupts,,Ampicillin,,,,gonorrhea,,,,, +24823382,757,,prevents,,Ampicillin,,,,Infection,,,,, +22838487,758,,prevents,,Ampicillin,,,,chorioamnionitis,,,,, +18801502,759,,prevents,,Ampicillin,,,,Sepsis,,,,, +17465667,760,,prevents,,Ampicillin,,,,pneumonia,,,,, +13675414,761,,predisposes,,Ampicillin,,,,Sepsis,,,,, +26048573,762,,causes,,Carbenicillin,,,,bacterial infectious disease,,,,, +19319362,763,,related to,,Benzoyl Peroxide,,,,acne,,,,, +10427135,764,,affects,,Benzoyl Peroxide,,,,acne,,,,, +7769964,765,,disrupts,,Benzoyl Peroxide,,,,acne,,,,, +12531968,766,,prevents,,Benzoyl Peroxide,,,,acne,,,,, +11597597,767,,related to,,Proglumide,,,,peptic ulcer disease,,,,, +18195146,768,,causes,,Pirenzepine,,,,peptic ulcer disease,,,,, +13022427,769,,affects,,Pirenzepine,,,,gastroesophageal reflux disease,,,,, +18547780,770,,prevents,,Pirenzepine,,,,peptic ulcer disease,,,,, +9345084,771,,related to,,Magnesium Oxide,,,,constipation disorder,,,,, +19628284,772,,disrupts,,Magnesium Oxide,,,,constipation disorder,,,,, +25714783,773,,prevents,,Ticarcillin,,,,Sepsis,,,,, +24735602,774,,related to,,Urea,,,,hepatocellular carcinoma,,,,, +18901918,775,,related to,,Urea,,,,radiodermatitis,,,,, +16423422,776,,related to,,Urea,,,,skin disorder,,,,, +16423421,777,,related to,,Urea,,,,psoriasis,,,,, +10983160,778,,related to,,Urea,,,,"dermatitis, atopic",,,,, +9883467,779,,related to,,Urea,,,,diabetes mellitus,,,,, +9435238,780,,related to,,Urea,,,,type 2 diabetes mellitus,,,,, +7778173,781,,related to,,Urea,,,,ornithine carbamoyltransferase deficiency,,,,, +17162115,782,,causes,,Urea,,,,diabetes mellitus,,,,, +16469778,783,,causes,,Urea,,,,type 2 diabetes mellitus,,,,, +18510405,784,,affects,,Urea,,,,hepatocellular carcinoma,,,,, +10531949,785,,affects,,Urea,,,,diabetes mellitus,,,,, +8735554,786,,affects,,Urea,,,,type 2 diabetes mellitus,,,,, +25972859,787,,produces,,Urea,,,,citrullinemia,,,,, +18901919,788,,prevents,,Urea,,,,radiodermatitis,,,,, +15303897,789,,prevents,,Urea,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +19154964,790,,predisposes,,Urea,,,,type 2 diabetes mellitus,,,,, +21175471,791,,related to,,Mannitol,,,,intracranial hypertension,,,,, +17706176,792,,related to,,Mannitol,,,,acute kidney failure,,,,, +17429747,793,,related to,,Mannitol,,,,stroke disorder,,,,, +15130853,794,,related to,,Mannitol,,,,brain cancer,,,,, +13201402,795,,related to,,Mannitol,,,,cystic fibrosis,,,,, +12470912,796,,related to,,Mannitol,,,,brain edema,,,,, +11875924,797,,related to,,Mannitol,,,,ciguatera fish poisoning,,,,, +10780851,798,,related to,,Mannitol,,,,brain injury,,,,, +8946483,799,,related to,,Mannitol,,,,bronchiectasis,,,,, +7891128,800,,related to,,Mannitol,,,,injury,,,,, +26278567,801,,causes,,Mannitol,,,,brain cancer,,,,, +25099324,802,,causes,,Mannitol,,,,hearing loss disorder,,,,, +21259902,803,,causes,,Mannitol,,,,brain injury,,,,, +18351985,804,,causes,,Mannitol,,,,hypotensive disorder,,,,, +15545947,805,,causes,,Mannitol,,,,brain edema,,,,, +12105301,806,,causes,,Mannitol,,,,intracranial hypertension,,,,, +11383337,807,,causes,,Mannitol,,,,injury,,,,, +9825580,808,,causes,,Mannitol,,,,acute kidney failure,,,,, +22439282,809,,affects,,Mannitol,,,,acute kidney failure,,,,, +18431992,810,,affects,,Mannitol,,,,hypotensive disorder,,,,, +10780860,811,,affects,,Mannitol,,,,brain injury,,,,, +10701562,812,,affects,,Mannitol,,,,injury,,,,, +10686125,813,,affects,,Mannitol,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +9315186,814,,affects,,Mannitol,,,,intracranial hypertension,,,,, +7084537,815,,affects,,Mannitol,,,,brain edema,,,,, +27493988,816,,disrupts,,Mannitol,,,,injury,,,,, +26052295,817,,disrupts,,Mannitol,,,,brain edema,,,,, +18331127,818,,prevents,,Mannitol,,,,Pain,,,,, +17838550,819,,prevents,,Mannitol,,,,brain injury,,,,, +9550870,820,,prevents,,Mannitol,,,,acute kidney failure,,,,, +8530867,821,,prevents,,Mannitol,,,,brain edema,,,,, +7816754,822,,prevents,,Mannitol,,,,intracranial hypertension,,,,, +21038220,823,,exacerbates,,Mannitol,,,,intracranial hypertension,,,,, +23554906,824,,predisposes,,Mannitol,,,,brain injury,,,,, +23171283,825,,predisposes,,Mannitol,,,,acute kidney failure,,,,, +15337034,826,,predisposes,,Mannitol,,,,brain edema,,,,, +9368450,827,,predisposes,,Mannitol,,,,injury,,,,, +25560945,828,,affects,,Artesunic acid,,,,neoplasm,,,,, +20380317,829,,affects,,Artesunic acid,,,,neoplasm,,,,, +17022154,830,,affects,,Artesunic acid,,,,cytomegalovirus infection,,,,, +15447136,831,,affects,,Artesunic acid,,,,malaria,,,,, +14695052,832,,affects,,Artesunic acid,,,,Fever,,,,, +9350747,833,,affects,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, +19053159,834,,disrupts,,Artesunic acid,,,,Plasmodium falciparum malaria,,,,, +17269195,835,,disrupts,,Artesunic acid,,,,neoplasm,,,,, +16806460,836,,disrupts,,Artesunic acid,,,,malaria,,,,, +10013375,837,,prevents,,Artesunic acid,,,,schistosomiasis,,,,, +8540473,838,,prevents,,Artesunic acid,,,,malaria,,,,, +16567243,839,,predisposes,,Artesunic acid,,,,malaria,,,,, +27639365,840,,affects,,Artemether,,,,Fever,,,,, +25565511,841,,affects,,Artemether,,,,malaria,,,,, +19253720,842,,prevents,,Artemether,,,,malaria,,,,, +10002115,843,,prevents,,Artemether,,,,urinary schistosomiasis,,,,, +8716445,844,,causes,,Isoproterenol,,,,atrial fibrillation,,,,, +25912644,845,,affects,,Isoproterenol,,,,obstructive lung disease,,,,, +24900253,846,,affects,,Isoproterenol,,,,obesity disorder,,,,, +9298156,847,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, +7542857,848,,affects,,Isoproterenol,,,,atrial fibrillation,,,,, +26721271,849,,disrupts,,Isoproterenol,,,,obesity disorder,,,,, +7635739,850,,predisposes,,Isoproterenol,,,,atrial fibrillation,,,,, +23874783,851,,related to,,Bacitracin A,,,,pneumonia,,,,, +26428368,852,,prevents,,Bacitracin A,,,,bacterial infectious disease,,,,, +18829774,853,,prevents,,Bacitracin A,,,,cardiac rhythm disease,,,,, +16650012,854,,subclass of,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, +26133976,855,,causes,,Diflunisal,,,,Pain,,,,, +26132411,856,,affects,,Diflunisal,,,,Pain,,,,, +26009871,857,,affects,,Diflunisal,,,,Fever,,,,, +26009870,858,,affects,,Diflunisal,,,,Fever,,,,, +13234484,859,,affects,,Diflunisal,,,,Diflunisal glucuronide ester,,,,, +14757294,860,,prevents,,Diflunisal,,,,Pain,,,,, +17020332,861,,causes,,Salsalate,,,,Insulin resistance,,,,, +21902985,862,,affects,,Salsalate,,,,diabetes mellitus,,,,, +25541729,863,,disrupts,,Salsalate,,,,Insulin resistance,,,,, +19533984,864,,prevents,,Salsalate,,,,diabetes mellitus,,,,, +26431050,865,,causes,,Sodium salicylate,,,,Fever,,,,, +11882723,866,,affects,,Sodium salicylate,,,,Fever,,,,, +9968696,867,,affects,,Sodium salicylate,,,,Fever,,,,, +15893532,868,,predisposes,,Sodium salicylate,,,,Pain,,,,, +7201382,869,,subclass of,,Aspirin,,,,Salicylic Acid,,,,, +26818861,870,,related to,,Aspirin,,,,myocardial infarction,,,,, +26532873,871,,related to,,Aspirin,,,,classic familial adenomatous polyposis,,,,, +26329928,872,,related to,,Aspirin,,,,type 2 diabetes mellitus,,,,, +26168722,873,,related to,,Aspirin,,,,Inflammation,,,,, +24076103,874,,related to,,Aspirin,,,,Hemorrhage,,,,, +20241570,875,,related to,,Aspirin,,,,Pain,,,,, +18524506,876,,related to,,Aspirin,,,,cataract,,,,, +18008074,877,,related to,,Aspirin,,,,diabetes mellitus,,,,, +17483160,878,,related to,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, +16078277,879,,related to,,Aspirin,,,,preeclampsia,,,,, +15283505,880,,related to,,Aspirin,,,,thrombotic disease,,,,, +13829413,881,,related to,,Aspirin,,,,retinal vein occlusion,,,,, +13174915,882,,related to,,Aspirin,,,,ST-elevation myocardial infarction,,,,, +12865539,883,,related to,,Aspirin,,,,cardiovascular disorder,,,,, +12749655,884,,related to,,Aspirin,,,,Salicylic Acid,,,,, +12502970,885,,related to,,Aspirin,,,,coronary artery disorder,,,,, +10635434,886,,related to,,Aspirin,,,,rheumatic heart disease,,,,, +10534181,887,,related to,,Aspirin,,,,osteoarthritis,,,,, +10473195,888,,related to,,Aspirin,,,,asthma,,,,, +9315521,889,,related to,,Aspirin,,,,atrial fibrillation,,,,, +8718389,890,,related to,,Aspirin,,,,stroke disorder,,,,, +8430499,891,,related to,,Aspirin,,,,Ischemic stroke,,,,, +7718877,892,,related to,,Aspirin,,,,acute coronary syndrome,,,,, +8745735,893,,related to,,Aspirin,,,,Salicylic Acid,,,,, +12749656,894,,close match,,Aspirin,,,,Salicylic Acid,,,,, +8745736,895,,close match,,Aspirin,,,,Salicylic Acid,,,,, +10716638,896,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, +10182446,897,,coexists with,,Aspirin,,,,Salicylic Acid,,,,, +8959647,898,,derives from,,Aspirin,,,,Salicylic Acid,,,,, +7421635,899,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, +9047883,900,,physically interacts with,,Aspirin,,,,Salicylic Acid,,,,, +27550629,901,,causes,,Aspirin,,,,transient ischemic attack,,,,, +27093984,902,,causes,,Aspirin,,,,Sepsis,,,,, +26941889,903,,causes,,Aspirin,,,,colonic neoplasm,,,,, +26621273,904,,causes,,Aspirin,,,,diabetic retinopathy,,,,, +25682183,905,,causes,,Aspirin,,,,Toothache,,,,, +24276147,906,,causes,,Aspirin,,,,osteoarthritis,,,,, +23603605,907,,causes,,Aspirin,,,,infertility disorder,,,,, +22149437,908,,causes,,Aspirin,,,,myocardial infarction,,,,, +21269587,909,,causes,,Aspirin,,,,preeclampsia,,,,, +21190178,910,,causes,,Aspirin,,,,Varicose Ulcer,,,,, +20967677,911,,causes,,Aspirin,,,,cerebral infarction,,,,, +20453125,912,,causes,,Aspirin,,,,squamous cell carcinoma,,,,, +20257764,913,,causes,,Aspirin,,,,vascular disorder,,,,, +18467493,914,,causes,,Aspirin,,,,periodontitis,,,,, +18133593,915,,causes,,Aspirin,,,,acute lung injury,,,,, +17905974,916,,causes,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, +16266546,917,,causes,,Aspirin,,,,cardiovascular disorder,,,,, +15908394,918,,causes,,Aspirin,,,,arthritic joint disease,,,,, +15782733,919,,causes,,Aspirin,,,,ulcerative colitis,,,,, +15251529,920,,causes,,Aspirin,,,,myocardial ischemia,,,,, +15022291,921,,causes,,Aspirin,,,,pneumonia,,,,, +14953515,922,,causes,,Aspirin,,,,diabetes mellitus,,,,, +14693157,923,,causes,,Aspirin,,,,atrial fibrillation,,,,, +14660024,924,,causes,,Aspirin,,,,ischemic disease,,,,, +14296178,925,,causes,,Aspirin,,,,type 2 diabetes mellitus,,,,, +13914591,926,,causes,,Aspirin,,,,digestive system disorder,,,,, +13814866,927,,causes,,Aspirin,,,,Fever,,,,, +13639281,928,,causes,,Aspirin,,,,acute coronary syndrome,,,,, +13639280,929,,causes,,Aspirin,,,,Ischemic stroke,,,,, +13405854,930,,causes,,Aspirin,,,,hypertensive disorder,,,,, +13278968,931,,causes,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, +11251562,932,,causes,,Aspirin,,,,Pain,,,,, +10850020,933,,causes,,Aspirin,,,,migraine disorder,,,,, +10555051,934,,causes,,Aspirin,,,,duodenal ulcer,,,,, +9350599,935,,causes,,Aspirin,,,,active peptic ulcer disease,,,,, +9238263,936,,causes,,Aspirin,,,,blood coagulation disease,,,,, +8683872,937,,causes,,Aspirin,,,,stroke disorder,,,,, +8518235,938,,causes,,Aspirin,,,,peptic ulcer disease,,,,, +8466167,939,,causes,,Aspirin,,,,Headache,,,,, +8232293,940,,causes,,Aspirin,,,,Hemorrhage,,,,, +7594346,941,,causes,,Aspirin,,,,asthma,,,,, +7353622,942,,causes,,Aspirin,,,,gastric ulcer,,,,, +7227553,943,,causes,,Aspirin,,,,injury,,,,, +26773149,944,,affects,,Aspirin,,,,atrial fibrillation,,,,, +26425353,945,,affects,,Aspirin,,,,atherosclerosis,,,,, +26396469,946,,affects,,Aspirin,,,,Dysmenorrhea,,,,, +25760183,947,,affects,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +24559876,948,,affects,,Aspirin,,,,coronary artery disorder,,,,, +23119254,949,,affects,,Aspirin,,,,brain aneurysm,,,,, +21758599,950,,affects,,Aspirin,,,,brain aneurysm,,,,, +21116359,951,,affects,,Aspirin,,,,major depressive disorder,,,,, +21116358,952,,affects,,Aspirin,,,,schizophrenia,,,,, +21031382,953,,affects,,Aspirin,,,,neoplasm,,,,, +20857373,954,,affects,,Aspirin,,,,melanoma,,,,, +20741170,955,,affects,,Aspirin,,,,fetal growth restriction,,,,, +20453126,956,,affects,,Aspirin,,,,squamous cell carcinoma,,,,, +19190473,957,,affects,,Aspirin,,,,acute lung injury,,,,, +18874269,958,,affects,,Aspirin,,,,preeclampsia,,,,, +18830463,959,,affects,,Aspirin,,,,Varicose Ulcer,,,,, +18706529,960,,affects,,Aspirin,,,,mucocutaneous lymph node syndrome,,,,, +18617993,961,,affects,,Aspirin,,,,Sepsis,,,,, +18348076,962,,affects,,Aspirin,,,,Headache,,,,, +18344374,963,,affects,,Aspirin,,,,bone fracture,,,,, +18277701,964,,affects,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, +18092588,965,,affects,,Aspirin,,,,Fever,,,,, +17810437,966,,affects,,Aspirin,,,,migraine disorder,,,,, +16655533,967,,affects,,Aspirin,,,,stroke disorder,,,,, +16466986,968,,affects,,Aspirin,,,,myocardial ischemia,,,,, +16123563,969,,affects,,Aspirin,,,,digestive system disorder,,,,, +15829936,970,,affects,,Aspirin,,,,hypertriglyceridemia,,,,, +15667690,971,,affects,,Aspirin,,,,hepatocellular carcinoma,,,,, +15311732,972,,affects,,Aspirin,,,,periodontitis,,,,, +15094783,973,,affects,,Aspirin,,,,diabetic retinopathy,,,,, +13831910,974,,affects,,Aspirin,,,,gastric ulcer,,,,, +13734334,975,,affects,,Aspirin,,,,Pregnancy,,,,, +13647977,976,,affects,,Aspirin,,,,neoplasm,,,,, +13624111,977,,affects,,Aspirin,,,,pneumonia,,,,, +13559011,978,,affects,,Aspirin,,,,type 2 diabetes mellitus,,,,, +13493823,979,,affects,,Aspirin,,,,thrombotic disease,,,,, +12884495,980,,affects,,Aspirin,,,,duodenal ulcer,,,,, +12815469,981,,affects,,Aspirin,,,,atherosclerosis,,,,, +12769418,982,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, +12607959,983,,affects,,Aspirin,,,,plasma cell myeloma,,,,, +12446363,984,,affects,,Aspirin,,,,hypertensive disorder,,,,, +12124867,985,,affects,,Aspirin,,,,heart disorder,,,,, +11661767,986,,affects,,Aspirin,,,,peptic ulcer disease,,,,, +11474111,987,,affects,,Aspirin,,,,diabetes mellitus,,,,, +11357781,988,,affects,,Aspirin,,,,ischemic disease,,,,, +11341534,989,,affects,,Aspirin,,,,ulcer disease,,,,, +11135514,990,,affects,,Aspirin,,,,cerebrovascular disorder,,,,, +10875862,991,,affects,,Aspirin,,,,acquired polycythemia vera,,,,, +10830878,992,,affects,,Aspirin,,,,Inflammation,,,,, +10337669,993,,affects,,Aspirin,,,,colorectal neoplasm,,,,, +10331252,994,,affects,,Aspirin,,,,peptic ulcer disease,,,,, +10226347,995,,affects,,Aspirin,,,,thrombophilia,,,,, +10082315,996,,affects,,Aspirin,,,,Pain,,,,, +10068618,997,,affects,,Aspirin,,,,adenoma,,,,, +9766251,998,,affects,,Aspirin,,,,injury,,,,, +9581221,999,,affects,,Aspirin,,,,cataract,,,,, +9528323,1000,,affects,,Aspirin,,,,asthma,,,,, +9510044,1001,,affects,,Aspirin,,,,transient ischemic attack,,,,, +9342553,1002,,affects,,Aspirin,,,,Salicylic Acid,,,,, +9259288,1003,,affects,,Aspirin,,,,Fever,,,,, +9203900,1004,,affects,,Aspirin,,,,Hypercholesterolemia,,,,, +9160463,1005,,affects,,Aspirin,,,,gastric ulcer,,,,, +9084341,1006,,affects,,Aspirin,,,,Ischemic stroke,,,,, +8650258,1007,,affects,,Aspirin,,,,Hemorrhage,,,,, +8543326,1008,,affects,,Aspirin,,,,active peptic ulcer disease,,,,, +8290962,1009,,affects,,Aspirin,,,,ulcer disease,,,,, +8187935,1010,,affects,,Aspirin,,,,injury,,,,, +8173134,1011,,affects,,Aspirin,,,,thrombotic disease,,,,, +8169760,1012,,affects,,Aspirin,,,,preeclampsia,,,,, +7935107,1013,,affects,,Aspirin,,,,prostate cancer,,,,, +7920712,1014,,affects,,Aspirin,,,,Hemorrhage,,,,, +7876600,1015,,affects,,Aspirin,,,,Hemorrhage,,,,, +7820545,1016,,affects,,Aspirin,,,,vascular disorder,,,,, +7816175,1017,,affects,,Aspirin,,,,Pregnancy,,,,, +7635677,1018,,affects,,Aspirin,,,,myocardial ischemia,,,,, +7478885,1019,,affects,,Aspirin,,,,coronary artery disorder,,,,, +7468514,1020,,affects,,Aspirin,,,,stroke disorder,,,,, +7251569,1021,,affects,,Aspirin,,,,myocardial infarction,,,,, +7213554,1022,,affects,,Aspirin,,,,cardiovascular disorder,,,,, +7156429,1023,,affects,,Aspirin,,,,Inflammation,,,,, +14159165,1024,,affects,,Aspirin,,,,Salicylic Acid,,,,, +27335099,1025,,disrupts,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +24958273,1026,,disrupts,,Aspirin,,,,Fever,,,,, +24520178,1027,,disrupts,,Aspirin,,,,melanoma,,,,, +24047967,1028,,disrupts,,Aspirin,,,,cardiovascular disorder,,,,, +22107293,1029,,disrupts,,Aspirin,,,,atrial fibrillation,,,,, +22100738,1030,,disrupts,,Aspirin,,,,fetal growth restriction,,,,, +22027792,1031,,disrupts,,Aspirin,,,,venous thromboembolism,,,,, +21434441,1032,,disrupts,,Aspirin,,,,thrombophilia,,,,, +20385507,1033,,disrupts,,Aspirin,,,,essential thrombocythemia,,,,, +19437129,1034,,disrupts,,Aspirin,,,,Sepsis,,,,, +19421638,1035,,disrupts,,Aspirin,,,,pneumonia,,,,, +19318532,1036,,disrupts,,Aspirin,,,,vascular disorder,,,,, +18604728,1037,,disrupts,,Aspirin,,,,type 2 diabetes mellitus,,,,, +18599969,1038,,disrupts,,Aspirin,,,,arthritic joint disease,,,,, +18445880,1039,,disrupts,,Aspirin,,,,ovarian cancer,,,,, +18225861,1040,,disrupts,,Aspirin,,,,Hemorrhage,,,,, +18203584,1041,,disrupts,,Aspirin,,,,brain aneurysm,,,,, +17476286,1042,,disrupts,,Aspirin,,,,Fatigue,,,,, +17225706,1043,,disrupts,,Aspirin,,,,transient ischemic attack,,,,, +16676314,1044,,disrupts,,Aspirin,,,,ulcer disease,,,,, +16484307,1045,,disrupts,,Aspirin,,,,acute lung injury,,,,, +14296080,1046,,disrupts,,Aspirin,,,,Pregnancy,,,,, +14068900,1047,,disrupts,,Aspirin,,,,active peptic ulcer disease,,,,, +13892678,1048,,disrupts,,Aspirin,,,,breast neoplasm,,,,, +13449558,1049,,disrupts,,Aspirin,,,,colorectal neoplasm,,,,, +12947740,1050,,disrupts,,Aspirin,,,,diabetic retinopathy,,,,, +12815470,1051,,disrupts,,Aspirin,,,,atherosclerosis,,,,, +12714476,1052,,disrupts,,Aspirin,,,,cataract,,,,, +12478523,1053,,disrupts,,Aspirin,,,,preeclampsia,,,,, +12450426,1054,,disrupts,,Aspirin,,,,Barrett esophagus,,,,, +12023670,1055,,disrupts,,Aspirin,,,,hypertensive disorder,,,,, +11827133,1056,,disrupts,,Aspirin,,,,diabetes mellitus,,,,, +10318928,1057,,disrupts,,Aspirin,,,,Myalgia,,,,, +9742254,1058,,disrupts,,Aspirin,,,,adenoma,,,,, +9148614,1059,,disrupts,,Aspirin,,,,neoplasm,,,,, +8526818,1060,,disrupts,,Aspirin,,,,myocardial infarction,,,,, +7995298,1061,,disrupts,,Aspirin,,,,Inflammation,,,,, +7878103,1062,,disrupts,,Aspirin,,,,prostate cancer,,,,, +7775480,1063,,disrupts,,Aspirin,,,,Pain,,,,, +7723340,1064,,disrupts,,Aspirin,,,,stroke disorder,,,,, +7712646,1065,,disrupts,,Aspirin,,,,coronary artery disorder,,,,, +7261879,1066,,disrupts,,Aspirin,,,,thrombotic disease,,,,, +24597938,1067,,prevents,,Aspirin,,,,thrombophilia,,,,, +24091248,1068,,prevents,,Aspirin,,,,disseminated intravascular coagulation,,,,, +24015329,1069,,prevents,,Aspirin,,,,neoplasm of esophagus,,,,, +23042755,1070,,prevents,,Aspirin,,,,brain aneurysm,,,,, +22291835,1071,,prevents,,Aspirin,,,,Hemorrhage,,,,, +21962376,1072,,prevents,,Aspirin,,,,venous thromboembolism,,,,, +21587985,1073,,prevents,,Aspirin,,,,blood coagulation disease,,,,, +21116357,1074,,prevents,,Aspirin,,,,schizophrenia,,,,, +20356983,1075,,prevents,,Aspirin,,,,acute lung injury,,,,, +20189716,1076,,prevents,,Aspirin,,,,brain infarction,,,,, +18414184,1077,,prevents,,Aspirin,,,,multiple sclerosis,,,,, +18344373,1078,,prevents,,Aspirin,,,,bone fracture,,,,, +17911903,1079,,prevents,,Aspirin,,,,adult acute respiratory distress syndrome,,,,, +17240995,1080,,prevents,,Aspirin,,,,hepatocellular carcinoma,,,,, +16163718,1081,,prevents,,Aspirin,,,,Sepsis,,,,, +15608454,1082,,prevents,,Aspirin,,,,squamous cell carcinoma,,,,, +14796348,1083,,prevents,,Aspirin,,,,arthritic joint disease,,,,, +14183452,1084,,prevents,,Aspirin,,,,pneumonia,,,,, +13992680,1085,,prevents,,Aspirin,,,,diabetes mellitus,,,,, +13992679,1086,,prevents,,Aspirin,,,,type 2 diabetes mellitus,,,,, +13770407,1087,,prevents,,Aspirin,,,,diabetic retinopathy,,,,, +13624060,1088,,prevents,,Aspirin,,,,injury,,,,, +13536062,1089,,prevents,,Aspirin,,,,non-small cell lung carcinoma,,,,, +13041448,1090,,prevents,,Aspirin,,,,atrial fibrillation,,,,, +12791249,1091,,prevents,,Aspirin,,,,asthma,,,,, +12594676,1092,,prevents,,Aspirin,,,,Fatigue,,,,, +12361944,1093,,prevents,,Aspirin,,,,active peptic ulcer disease,,,,, +12273189,1094,,prevents,,Aspirin,,,,Myalgia,,,,, +11593026,1095,,prevents,,Aspirin,,,,colorectal neoplasm,,,,, +11289178,1096,,prevents,,Aspirin,,,,migraine disorder,,,,, +11042545,1097,,prevents,,Aspirin,,,,Barrett esophagus,,,,, +10366572,1098,,prevents,,Aspirin,,,,cerebrovascular disorder,,,,, +10293726,1099,,prevents,,Aspirin,,,,prostate cancer,,,,, +10185706,1100,,prevents,,Aspirin,,,,colonic neoplasm,,,,, +10099399,1101,,prevents,,Aspirin,,,,atherosclerosis,,,,, +10096705,1102,,prevents,,Aspirin,,,,cerebral infarction,,,,, +10004143,1103,,prevents,,Aspirin,,,,blindness (disorder),,,,, +9665356,1104,,prevents,,Aspirin,,,,hypertensive disorder,,,,, +9388878,1105,,prevents,,Aspirin,,,,coronary artery disorder,,,,, +9150304,1106,,prevents,,Aspirin,,,,habitual spontaneous abortion,,,,, +8853513,1107,,prevents,,Aspirin,,,,gastric ulcer,,,,, +8755758,1108,,prevents,,Aspirin,,,,vascular disorder,,,,, +8494726,1109,,prevents,,Aspirin,,,,ulcer disease,,,,, +8347839,1110,,prevents,,Aspirin,,,,peptic ulcer disease,,,,, +8325441,1111,,prevents,,Aspirin,,,,ischemic disease,,,,, +7877588,1112,,prevents,,Aspirin,,,,cardiovascular disorder,,,,, +7852267,1113,,prevents,,Aspirin,,,,Headache,,,,, +7716613,1114,,prevents,,Aspirin,,,,neoplasm,,,,, +7603499,1115,,prevents,,Aspirin,,,,myocardial ischemia,,,,, +7487700,1116,,prevents,,Aspirin,,,,Inflammation,,,,, +7457050,1117,,prevents,,Aspirin,,,,peripheral vascular disease,,,,, +7455467,1118,,prevents,,Aspirin,,,,Ischemic stroke,,,,, +7455466,1119,,prevents,,Aspirin,,,,stroke disorder,,,,, +7455465,1120,,prevents,,Aspirin,,,,transient ischemic attack,,,,, +7419265,1121,,prevents,,Aspirin,,,,heart disorder,,,,, +7368248,1122,,prevents,,Aspirin,,,,thrombotic disease,,,,, +7317027,1123,,prevents,,Aspirin,,,,preeclampsia,,,,, +7275741,1124,,prevents,,Aspirin,,,,acute coronary syndrome,,,,, +7264064,1125,,prevents,,Aspirin,,,,Pain,,,,, +7196018,1126,,prevents,,Aspirin,,,,myocardial infarction,,,,, +7159192,1127,,prevents,,Aspirin,,,,fetal growth restriction,,,,, +7110859,1128,,prevents,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +22126985,1129,,exacerbates,,Aspirin,,,,gastric ulcer,,,,, +21411566,1130,,exacerbates,,Aspirin,,,,macular degeneration,,,,, +21359197,1131,,exacerbates,,Aspirin,,,,acute coronary syndrome,,,,, +26115547,1132,,predisposes,,Aspirin,,,,cerebral infarction,,,,, +25254777,1133,,predisposes,,Aspirin,,,,essential thrombocythemia,,,,, +23315977,1134,,predisposes,,Aspirin,,,,brain aneurysm,,,,, +21525767,1135,,predisposes,,Aspirin,,,,Fever,,,,, +21487721,1136,,predisposes,,Aspirin,,,,Hemorrhage,,,,, +20679052,1137,,predisposes,,Aspirin,,,,blood coagulation disease,,,,, +20234206,1138,,predisposes,,Aspirin,,,,hepatocellular carcinoma,,,,, +20155873,1139,,predisposes,,Aspirin,,,,placental insufficiency,,,,, +19346376,1140,,predisposes,,Aspirin,,,,chronic renal failure syndrome,,,,, +18235965,1141,,predisposes,,Aspirin,,,,macular degeneration,,,,, +17872103,1142,,predisposes,,Aspirin,,,,atrial fibrillation,,,,, +17123250,1143,,predisposes,,Aspirin,,,,acute coronary syndrome,,,,, +16813141,1144,,predisposes,,Aspirin,,,,melanoma,,,,, +16162173,1145,,predisposes,,Aspirin,,,,ulcerative colitis,,,,, +15461534,1146,,predisposes,,Aspirin,,,,gastric ulcer,,,,, +14856258,1147,,predisposes,,Aspirin,,,,neoplasm of esophagus,,,,, +14426809,1148,,predisposes,,Aspirin,,,,neoplasm,,,,, +14234947,1149,,predisposes,,Aspirin,,,,diabetes mellitus,,,,, +14126301,1150,,predisposes,,Aspirin,,,,cerebrovascular disorder,,,,, +14052964,1151,,predisposes,,Aspirin,,,,Inflammation,,,,, +14015029,1152,,predisposes,,Aspirin,,,,transient ischemic attack,,,,, +13644771,1153,,predisposes,,Aspirin,,,,asthma,,,,, +13536064,1154,,predisposes,,Aspirin,,,,non-small cell lung carcinoma,,,,, +13299957,1155,,predisposes,,Aspirin,,,,ovarian cancer,,,,, +12673405,1156,,predisposes,,Aspirin,,,,bone fracture,,,,, +12382415,1157,,predisposes,,Aspirin,,,,colorectal neoplasm,,,,, +11071059,1158,,predisposes,,Aspirin,,,,injury,,,,, +10962122,1159,,predisposes,,Aspirin,,,,ischemic disease,,,,, +10547299,1160,,predisposes,,Aspirin,,,,coronary artery disorder,,,,, +10337650,1161,,predisposes,,Aspirin,,,,adenoma,,,,, +9857077,1162,,predisposes,,Aspirin,,,,vascular disorder,,,,, +9535755,1163,,predisposes,,Aspirin,,,,thrombotic disease,,,,, +9535754,1164,,predisposes,,Aspirin,,,,hypertensive disorder,,,,, +9491661,1165,,predisposes,,Aspirin,,,,cardiovascular disorder,,,,, +9477464,1166,,predisposes,,Aspirin,,,,prostate cancer,,,,, +9404829,1167,,predisposes,,Aspirin,,,,ulcer disease,,,,, +8850172,1168,,predisposes,,Aspirin,,,,myocardial ischemia,,,,, +8763743,1169,,predisposes,,Aspirin,,,,thrombophilia due to thrombin defect,,,,, +8545255,1170,,predisposes,,Aspirin,,,,Ischemic stroke,,,,, +7865543,1171,,predisposes,,Aspirin,,,,Headache,,,,, +7858710,1172,,predisposes,,Aspirin,,,,myocardial infarction,,,,, +7667039,1173,,predisposes,,Aspirin,,,,preeclampsia,,,,, +7659453,1174,,predisposes,,Aspirin,,,,stroke disorder,,,,, +7653535,1175,,predisposes,,Aspirin,,,,peptic ulcer disease,,,,, +7596288,1176,,predisposes,,Aspirin,,,,atherosclerosis,,,,, +7078619,1177,,predisposes,,Aspirin,,,,active peptic ulcer disease,,,,, +23297288,1178,,prevents,,Vemurafenib,,,,neoplasm,,,,, +22851133,1179,,related to,,Dabrafenib,,,,melanoma,,,,, +18622575,1180,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +18622575,1181,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +26359747,1182,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +26359747,1183,,related to,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +24697302,1184,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +24697302,1185,,has part,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +10513644,1186,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +10513644,1187,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +15306394,1188,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +15306394,1189,,coexists with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +10518221,1190,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +9906740,1191,,physically interacts with,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +8278260,1192,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +9085295,1193,,affects,,Sodium heparin,,,,PROTAMINE SULFATE,,,,, +25915149,1194,,related to,,Sodium monofluorophosphate,,,,dental caries,,,,, +25861359,1195,,disrupts,,Sodium monofluorophosphate,,,,allergic disease,,,,, +19241020,1196,,related to,,Sodium Fluoride,,,,gingivitis,,,,, +17448182,1197,,related to,,Sodium Fluoride,,,,aortic valve stenosis,,,,, +9111981,1198,,related to,,Sodium Fluoride,,,,dental caries,,,,, +25583763,1199,,causes,,Sodium Fluoride,,,,dental fluorosis,,,,, +23780312,1200,,affects,,Sodium Fluoride,,,,dental caries,,,,, +18846793,1201,,affects,,Sodium Fluoride,,,,allergic disease,,,,, +25986070,1202,,disrupts,,Sodium Fluoride,,,,allergic disease,,,,, +14286543,1203,,prevents,,Sodium Fluoride,,,,gingivitis,,,,, +10538561,1204,,prevents,,Sodium Fluoride,,,,periodontal disorder,,,,, +10425615,1205,,prevents,,Sodium Fluoride,,,,dental caries,,,,, +19971424,1206,,related to,,Rifaximin,,,,irritable bowel syndrome,,,,, +17053293,1207,,related to,,Rifaximin,,,,hepatic encephalopathy,,,,, +18714048,1208,,causes,,Rifaximin,,,,irritable bowel syndrome,,,,, +8925773,1209,,causes,,Rifaximin,,,,diarrheal disease,,,,, +25434952,1210,,affects,,Rifaximin,,,,alcoholic hepatitis,,,,, +24257624,1211,,affects,,Rifaximin,,,,Infection,,,,, +20149851,1212,,affects,,Rifaximin,,,,Crohn disease,,,,, +19665399,1213,,affects,,Rifaximin,,,,diverticulitis,,,,, +18685028,1214,,affects,,Rifaximin,,,,irritable bowel syndrome,,,,, +16575444,1215,,affects,,Rifaximin,,,,hepatic encephalopathy,,,,, +21278571,1216,,prevents,,Rifaximin,,,,alcoholic hepatitis,,,,, +16143515,1217,,prevents,,Rifaximin,,,,diverticulitis,,,,, +15134586,1218,,prevents,,Rifaximin,,,,hepatic encephalopathy,,,,, +11830138,1219,,prevents,,Rifaximin,,,,irritable bowel syndrome,,,,, +11830137,1220,,prevents,,Rifaximin,,,,diarrheal disease,,,,, +15717459,1221,,predisposes,,Rifaximin,,,,hepatic encephalopathy,,,,, +25706307,1222,,related to,,Glycine,,,,cystic fibrosis,,,,, +20102524,1223,,related to,,Glycine,,,,psychotic disorder,,,,, +17514096,1224,,related to,,Glycine,,,,hypertensive disorder,,,,, +13080824,1225,,related to,,Glycine,,,,Alzheimer disease,,,,, +12589996,1226,,related to,,Glycine,,,,nutritional disorder,,,,, +7298031,1227,,related to,,Glycine,,,,schizophrenia,,,,, +17397486,1228,,causes,,Glycine,,,,Cognitive impairment,,,,, +17125423,1229,,affects,,Glycine,,,,asthma,,,,, +7530162,1230,,affects,,Glycine,,,,schizophrenia,,,,, +12589998,1231,,produces,,Glycine,,,,nutritional disorder,,,,, +16845009,1232,,disrupts,,Glycine,,,,Alzheimer disease,,,,, +12278394,1233,,prevents,,Glycine,,,,hypertensive disorder,,,,, +15546112,1234,,predisposes,,Glycine,,,,asthma,,,,, +16711324,1235,,related to,,Sorbitol,,,,injury,,,,, +10684679,1236,,related to,,Sorbitol,,,,constipation disorder,,,,, +20821510,1237,,causes,,Sorbitol,,,,constipation disorder,,,,, +15564538,1238,,causes,,Sorbitol,,,,injury,,,,, +17658899,1239,,affects,,Sorbitol,,,,osteoarthritis,,,,, +26106951,1240,,prevents,,Sorbitol,,,,injury,,,,, +10478248,1241,,affects,,Foscarnet,,,,cytomegalovirus infection,,,,, +10481132,1242,,prevents,,Foscarnet,,,,cytomegalovirus infection,,,,, +22857734,1243,,prevents,,Atogepant,,,,migraine disorder,,,,, +25325960,1244,,prevents,,Rimegepant,,,,migraine disorder,,,,, +21939131,1245,,prevents,,Rimegepant,,,,Pain,,,,, +10553741,1246,,related to,,ATROPINE,,,,poisoning,,,,, +19468294,1247,,causes,,ATROPINE,,,,Pain,,,,, +18989245,1248,,causes,,ATROPINE,,,,digestive system disorder,,,,, +14576640,1249,,causes,,ATROPINE,,,,myopia,,,,, +10716177,1250,,causes,,ATROPINE,,,,Mydriasis,,,,, +10361041,1251,,causes,,ATROPINE,,,,amblyopia,,,,, +9746341,1252,,causes,,ATROPINE,,,,poisoning,,,,, +9301311,1253,,causes,,ATROPINE,,,,cardiac arrest,,,,, +8524259,1254,,causes,,ATROPINE,,,,Insulin resistance,,,,, +8480152,1255,,causes,,ATROPINE,,,,Bradycardia,,,,, +26343406,1256,,affects,,ATROPINE,,,,hypoglycemia,,,,, +23118209,1257,,affects,,ATROPINE,,,,Mydriasis,,,,, +19520979,1258,,affects,,ATROPINE,,,,hypoglycemia,,,,, +12406813,1259,,affects,,ATROPINE,,,,cardiac arrest,,,,, +11741867,1260,,affects,,ATROPINE,,,,Bradycardia,,,,, +10264479,1261,,affects,,ATROPINE,,,,Hemorrhage,,,,, +9293832,1262,,affects,,ATROPINE,,,,poisoning,,,,, +9041302,1263,,affects,,ATROPINE,,,,Bradycardia,,,,, +7845760,1264,,affects,,ATROPINE,,,,Bradycardia,,,,, +7111083,1265,,affects,,ATROPINE,,,,myopia,,,,, +26141463,1266,,disrupts,,ATROPINE,,,,hypoglycemia,,,,, +23143978,1267,,disrupts,,ATROPINE,,,,poisoning,,,,, +20133204,1268,,disrupts,,ATROPINE,,,,Pain,,,,, +18168420,1269,,disrupts,,ATROPINE,,,,Bradycardia,,,,, +7111084,1270,,disrupts,,ATROPINE,,,,myopia,,,,, +9676858,1271,,prevents,,ATROPINE,,,,poisoning,,,,, +9198373,1272,,prevents,,ATROPINE,,,,myopia,,,,, +8451883,1273,,prevents,,ATROPINE,,,,cardiac arrest,,,,, +23699298,1274,,predisposes,,ATROPINE,,,,myopia,,,,, +14640163,1275,,predisposes,,ATROPINE,,,,poisoning,,,,, +7953996,1276,,affects,,Tolcapone,,,,Parkinson disease,,,,, +15643297,1277,,related to,,Entacapone,,,,Parkinson disease,,,,, +10033650,1278,,causes,,Entacapone,,,,Parkinson disease,,,,, +15952178,1279,,affects,,Entacapone,,,,Parkinson disease,,,,, +20308336,1280,,disrupts,,Entacapone,,,,Parkinson disease,,,,, +25394620,1281,,affects,,Veliparib,,,,neoplasm,,,,, +21697473,1282,,affects,,Veliparib,,,,triple-negative breast carcinoma,,,,, +21882624,1283,,causes,,Talazoparib,,,,neoplasm,,,,, +22572154,1284,,affects,,Talazoparib,,,,neoplasm,,,,, +21697476,1285,,affects,,Talazoparib,,,,triple-negative breast carcinoma,,,,, +22916819,1286,,prevents,,Talazoparib,,,,neoplasm,,,,, +24451977,1287,,related to,,Olaparib,,,,triple-negative breast carcinoma,,,,, +25473017,1288,,causes,,Olaparib,,,,pancreatic ductal adenocarcinoma,,,,, +25473016,1289,,causes,,Olaparib,,,,non-small cell lung carcinoma,,,,, +22160122,1290,,causes,,Olaparib,,,,head and neck neoplasm,,,,, +24770500,1291,,affects,,Olaparib,,,,castration-resistant prostate carcinoma,,,,, +24672020,1292,,affects,,Olaparib,,,,prostate cancer,,,,, +22977330,1293,,affects,,Olaparib,,,,neoplasm,,,,, +21697474,1294,,affects,,Olaparib,,,,triple-negative breast carcinoma,,,,, +24201965,1295,,prevents,,Olaparib,,,,Neoplasm Metastasis,,,,, +27698235,1296,,related to,,Capsaicin,,,,arthritic joint disease,,,,, +22276323,1297,,related to,,Capsaicin,,,,herpes zoster,,,,, +13200623,1298,,related to,,Capsaicin,,,,migraine disorder,,,,, +11537529,1299,,related to,,Capsaicin,,,,Cough,,,,, +10028696,1300,,related to,,Capsaicin,,,,diabetic neuropathy,,,,, +8608120,1301,,related to,,Capsaicin,,,,osteoarthritis,,,,, +8470968,1302,,related to,,Capsaicin,,,,postherpetic neuralgia,,,,, +8246278,1303,,related to,,Capsaicin,,,,neuralgia,,,,, +7965643,1304,,related to,,Capsaicin,,,,Pruritus,,,,, +7239245,1305,,related to,,Capsaicin,,,,Pain,,,,, +26554289,1306,,causes,,Capsaicin,,,,stroke disorder,,,,, +24505933,1307,,causes,,Capsaicin,,,,Muscle spasm,,,,, +18391785,1308,,causes,,Capsaicin,,,,neuralgia,,,,, +16420383,1309,,causes,,Capsaicin,,,,migraine disorder,,,,, +11163813,1310,,causes,,Capsaicin,,,,arthritic joint disease,,,,, +9650510,1311,,causes,,Capsaicin,,,,Myalgia,,,,, +8975038,1312,,causes,,Capsaicin,,,,Vomiting,,,,, +8261437,1313,,causes,,Capsaicin,,,,Cough,,,,, +7430731,1314,,causes,,Capsaicin,,,,Pruritus,,,,, +7414435,1315,,causes,,Capsaicin,,,,Pain,,,,, +27524804,1316,,affects,,Capsaicin,,,,arthritic joint disease,,,,, +25438971,1317,,affects,,Capsaicin,,,,brain injury,,,,, +19404541,1318,,affects,,Capsaicin,,,,neuroma,,,,, +15791019,1319,,affects,,Capsaicin,,,,Pruritus,,,,, +10951234,1320,,affects,,Capsaicin,,,,stroke disorder,,,,, +10764355,1321,,affects,,Capsaicin,,,,Pain,,,,, +10290167,1322,,affects,,Capsaicin,,,,Pruritus,,,,, +10171204,1323,,affects,,Capsaicin,,,,neuralgia,,,,, +8975035,1324,,affects,,Capsaicin,,,,Vomiting,,,,, +8515286,1325,,affects,,Capsaicin,,,,Pain,,,,, +8515285,1326,,affects,,Capsaicin,,,,postherpetic neuralgia,,,,, +8441743,1327,,affects,,Capsaicin,,,,Cough,,,,, +7281158,1328,,affects,,Capsaicin,,,,Cough,,,,, +18283970,1329,,disrupts,,Capsaicin,,,,Pain,,,,, +17652809,1330,,disrupts,,Capsaicin,,,,arthritic joint disease,,,,, +14643733,1331,,disrupts,,Capsaicin,,,,breast neoplasm,,,,, +9869751,1332,,disrupts,,Capsaicin,,,,Cough,,,,, +8160008,1333,,disrupts,,Capsaicin,,,,Pruritus,,,,, +25438980,1334,,prevents,,Capsaicin,,,,brain injury,,,,, +20404597,1335,,prevents,,Capsaicin,,,,postherpetic neuralgia,,,,, +17168513,1336,,prevents,,Capsaicin,,,,migraine disorder,,,,, +16978917,1337,,prevents,,Capsaicin,,,,neuralgia,,,,, +15822967,1338,,prevents,,Capsaicin,,,,stroke disorder,,,,, +10290168,1339,,prevents,,Capsaicin,,,,Pruritus,,,,, +8608117,1340,,prevents,,Capsaicin,,,,osteoarthritis,,,,, +8246280,1341,,prevents,,Capsaicin,,,,Pain,,,,, +14706687,1342,,predisposes,,Capsaicin,,,,Pain,,,,, +24021484,1343,,causes,,Nusinersen,,,,spinal muscular atrophy,,,,, +22907909,1344,,affects,,Nusinersen,,,,spinal muscular atrophy,,,,, +27681284,1345,,related to,,Hyaluronic acid sodium salt,,,,alcoholic hepatitis,,,,, +26794689,1346,,related to,,Hyaluronic acid sodium salt,,,,carpal tunnel syndrome,,,,, +20903427,1347,,related to,,Hyaluronic acid sodium salt,,,,Skin ulcer,,,,, +18915649,1348,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +18915649,1349,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +15362486,1350,,related to,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, +14268478,1351,,related to,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, +9147590,1352,,related to,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, +7458117,1353,,related to,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +17074499,1354,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +17074499,1355,,related to,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +12401778,1356,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +12401778,1357,,has part,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +11319224,1358,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +11319224,1359,,coexists with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +7287149,1360,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +7699622,1361,,physically interacts with,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +12146167,1362,,causes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +8938037,1363,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +8541022,1364,,affects,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +7683831,1365,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +7895314,1366,,affects,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +18839068,1367,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +18839068,1368,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +9813251,1369,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +9813251,1370,,produces,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +17165364,1371,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +17165364,1372,,has input,,Hyaluronic acid sodium salt,,,,Hyaluronidase,,,,, +23839601,1373,,disrupts,,Hyaluronic acid sodium salt,,,,dry eye syndrome,,,,, +22764727,1374,,disrupts,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, +7155073,1375,,disrupts,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +18262848,1376,,prevents,,Hyaluronic acid sodium salt,,,,chronic obstructive pulmonary disease,,,,, +11511344,1377,,prevents,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +21264578,1378,,predisposes,,Hyaluronic acid sodium salt,,,,intervertebral disc degenerative disorder,,,,, +11605823,1379,,predisposes,,Hyaluronic acid sodium salt,,,,osteoarthritis,,,,, +24659748,1380,,related to,,Zoledronic acid,,,,osteoporosis,,,,, +18902207,1381,,causes,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, +18856931,1382,,causes,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, +13083414,1383,,causes,,Zoledronic acid,,,,bone fracture,,,,, +21044659,1384,,affects,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, +19059032,1385,,affects,,Zoledronic acid,,,,bone osteosarcoma,,,,, +13892047,1386,,affects,,Zoledronic acid,,,,bone fracture,,,,, +13448998,1387,,affects,,Zoledronic acid,,,,osteonecrosis,,,,, +9617769,1388,,affects,,Zoledronic acid,,,,osteoporosis,,,,, +24472422,1389,,disrupts,,Zoledronic acid,,,,sarcoma,,,,, +20879055,1390,,disrupts,,Zoledronic acid,,,,Neoplasm Metastasis,,,,, +20879053,1391,,disrupts,,Zoledronic acid,,,,Pain,,,,, +13311906,1392,,disrupts,,Zoledronic acid,,,,hepatocellular carcinoma,,,,, +9617771,1393,,disrupts,,Zoledronic acid,,,,bone fracture,,,,, +22662537,1394,,prevents,,Zoledronic acid,,,,osteoporosis,,,,, +20148397,1395,,prevents,,Zoledronic acid,,,,osteonecrosis,,,,, +13621414,1396,,prevents,,Zoledronic acid,,,,bone fracture,,,,, +12127006,1397,,prevents,,Zoledronic acid,,,,Marchiafava-Bignami disease,,,,, +20851623,1398,,predisposes,,Zoledronic acid,,,,bone fracture,,,,, +15272127,1399,,predisposes,,Zoledronic acid,,,,osteonecrosis,,,,, +14006582,1400,,prevents,,Risedronic acid,,,,osteoporosis,,,,, +17290459,1401,,affects,,IBANDRONIC ACID,,,,osteonecrosis,,,,, +9797983,1402,,affects,,IBANDRONIC ACID,,,,Neoplasm Metastasis,,,,, +15290649,1403,,prevents,,IBANDRONIC ACID,,,,bone disorder,,,,, +13697992,1404,,prevents,,IBANDRONIC ACID,,,,Pain,,,,, +10307139,1405,,prevents,,IBANDRONIC ACID,,,,postmenopausal osteoporosis,,,,, +10028971,1406,,prevents,,IBANDRONIC ACID,,,,osteoporosis,,,,, +18363632,1407,,predisposes,,IBANDRONIC ACID,,,,Abdominal pain,,,,, +9434475,1408,,predisposes,,IBANDRONIC ACID,,,,osteoporosis,,,,, +17514758,1409,,related to,,Alendronic acid,,,,osteoarthritis,,,,, +14283477,1410,,related to,,Alendronic acid,,,,osteoporosis,,,,, +11575454,1411,,related to,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +14254304,1412,,causes,,Alendronic acid,,,,asthma,,,,, +14049757,1413,,causes,,Alendronic acid,,,,osteoporosis,,,,, +11710947,1414,,causes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +25124892,1415,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +24296937,1416,,affects,,Alendronic acid,,,,bone disorder,,,,, +17701514,1417,,affects,,Alendronic acid,,,,osteoarthritis,,,,, +14769549,1418,,affects,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +12316243,1419,,affects,,Alendronic acid,,,,osteoporosis,,,,, +12136907,1420,,affects,,Alendronic acid,,,,periodontitis,,,,, +8809813,1421,,affects,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +22627610,1422,,disrupts,,Alendronic acid,,,,aortic valve stenosis,,,,, +17047070,1423,,disrupts,,Alendronic acid,,,,prostate cancer,,,,, +9109277,1424,,disrupts,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +8466156,1425,,disrupts,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +24628288,1426,,prevents,,Alendronic acid,,,,osteoarthritis,,,,, +15290647,1427,,prevents,,Alendronic acid,,,,bone disorder,,,,, +7495571,1428,,prevents,,Alendronic acid,,,,osteoporosis,,,,, +7314446,1429,,prevents,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +7150371,1430,,prevents,,Alendronic acid,,,,postmenopausal osteoporosis,,,,, +25381093,1431,,predisposes,,Alendronic acid,,,,osteoporosis,,,,, +22975353,1432,,predisposes,,Alendronic acid,,,,Marchiafava-Bignami disease,,,,, +12652815,1433,,related to,,Pamidronic acid,,,,osteoporosis,,,,, +7541169,1434,,related to,,Pamidronic acid,,,,plasma cell myeloma,,,,, +12040766,1435,,affects,,Pamidronic acid,,,,plasma cell myeloma,,,,, +10860757,1436,,affects,,Pamidronic acid,,,,osteoporosis,,,,, +9170219,1437,,prevents,,Pamidronic acid,,,,osteoporosis,,,,, +9315699,1438,,prevents,,Octyl methoxycinnamate,,,,sunburn,,,,, +10529058,1439,,coexists with,,4-Aminobenzoic acid,,,,Procaine,,,,, +25771688,1440,,causes,,Nitrazepam,,,,epilepsy,,,,, +19206956,1441,,affects,,Nitrazepam,,,,depressive disorder,,,,, +25737609,1442,,disrupts,,Nitrazepam,,,,epilepsy,,,,, +7322742,1443,,prevents,,Nitrazepam,,,,epilepsy,,,,, +25779340,1444,,causes,,Flurazepam,,,,depressive disorder,,,,, +19092155,1445,,causes,,Triazolam,,,,depressive disorder,,,,, +16852864,1446,,causes,,Triazolam,,,,insomnia,,,,, +27224077,1447,,affects,,Triazolam,,,,insomnia,,,,, +15159227,1448,,disrupts,,Triazolam,,,,anxiety,,,,, +24702695,1449,,related to,,Midazolam,,,,delirium,,,,, +16327495,1450,,related to,,Midazolam,,,,obesity disorder,,,,, +17503618,1451,,causes,,Midazolam,,,,Nausea,,,,, +13087342,1452,,causes,,Midazolam,,,,status epilepticus,,,,, +12880145,1453,,causes,,Midazolam,,,,delirium,,,,, +12134398,1454,,causes,,Midazolam,,,,brain injury,,,,, +11162624,1455,,causes,,Midazolam,,,,Pain,,,,, +10221339,1456,,causes,,Midazolam,,,,injury,,,,, +10197463,1457,,causes,,Midazolam,,,,epilepsy,,,,, +7739374,1458,,causes,,Midazolam,,,,hypotensive disorder,,,,, +7211473,1459,,causes,,Midazolam,,,,depressive disorder,,,,, +7104276,1460,,causes,,Midazolam,,,,dissociative amnesia,,,,, +27271852,1461,,affects,,Midazolam,,,,Pruritus,,,,, +26121850,1462,,affects,,Midazolam,,,,Pain,,,,, +25522494,1463,,affects,,Midazolam,,,,anxiety,,,,, +22514965,1464,,affects,,Midazolam,,,,anxiety,,,,, +22203290,1465,,affects,,Midazolam,,,,post-traumatic stress disorder,,,,, +21411467,1466,,affects,,Midazolam,,,,Suicidal ideation,,,,, +20820424,1467,,affects,,Midazolam,,,,injury,,,,, +20230773,1468,,affects,,Midazolam,,,,hypotensive disorder,,,,, +19683992,1469,,affects,,Midazolam,,,,injury,,,,, +18986257,1470,,affects,,Midazolam,,,,neoplasm,,,,, +18893940,1471,,affects,,Midazolam,,,,hypertensive disorder,,,,, +18670184,1472,,affects,,Midazolam,,,,hypotensive disorder,,,,, +18644607,1473,,affects,,Midazolam,,,,neuralgia,,,,, +18331473,1474,,affects,,Midazolam,,,,status epilepticus,,,,, +17655582,1475,,affects,,Midazolam,,,,Cough,,,,, +12605496,1476,,affects,,Midazolam,,,,dissociative amnesia,,,,, +12154940,1477,,affects,,Midazolam,,,,Nausea,,,,, +11981571,1478,,affects,,Midazolam,,,,delirium,,,,, +8867560,1479,,affects,,Midazolam,,,,Pain,,,,, +8871799,1480,,affects,,Midazolam,,,,hypotensive disorder,,,,, +8701804,1481,,affects,,Midazolam,,,,epilepsy,,,,, +8569605,1482,,affects,,Midazolam,,,,brain injury,,,,, +7116661,1483,,affects,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, +20025306,1484,,disrupts,,Midazolam,,,,Pruritus,,,,, +18424847,1485,,disrupts,,Midazolam,,,,status epilepticus,,,,, +16150704,1486,,disrupts,,Midazolam,,,,Cough,,,,, +14733481,1487,,disrupts,,Midazolam,,,,neuralgia,,,,, +13861580,1488,,disrupts,,Midazolam,,,,Pain,,,,, +9443524,1489,,disrupts,,Midazolam,,,,epilepsy,,,,, +7819099,1490,,disrupts,,Midazolam,,,,anxiety,,,,, +21663738,1491,,prevents,,Midazolam,,,,anxiety,,,,, +20820423,1492,,prevents,,Midazolam,,,,injury,,,,, +17322994,1493,,prevents,,Midazolam,,,,Aggressive behavior,,,,, +16397367,1494,,prevents,,Midazolam,,,,status epilepticus,,,,, +13467675,1495,,prevents,,Midazolam,,,,Nausea,,,,, +11373548,1496,,prevents,,Midazolam,,,,Cough,,,,, +11041799,1497,,prevents,,Midazolam,,,,bone fracture,,,,, +9493413,1498,,prevents,,Midazolam,,,,epilepsy,,,,, +8653279,1499,,prevents,,Midazolam,,,,Sepsis,,,,, +8569600,1500,,prevents,,Midazolam,,,,brain injury,,,,, +8151023,1501,,prevents,,Midazolam,,,,Pain,,,,, +7116663,1502,,prevents,,Midazolam,,,,Postoperative Nausea and Vomiting,,,,, +16657523,1503,,exacerbates,,Midazolam,,,,Sepsis,,,,, +19191198,1504,,predisposes,,Midazolam,,,,dissociative amnesia,,,,, +18422952,1505,,predisposes,,Midazolam,,,,status epilepticus,,,,, +11981572,1506,,predisposes,,Midazolam,,,,delirium,,,,, +22402246,1507,,disrupts,,Brotizolam,,,,anxiety,,,,, +12312025,1508,,related to,,Ganirelix,,,,polycystic ovary syndrome,,,,, +14831488,1509,,disrupts,,Cetrorelix,,,,benign prostatic hyperplasia,,,,, +18703871,1510,,prevents,,Cetrorelix,,,,endometriosis,,,,, +18874469,1511,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +18874469,1512,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +12069194,1513,,related to,,Methoxsalen,,,,mycosis fungoides,,,,, +8610329,1514,,related to,,Methoxsalen,,,,psoriasis,,,,, +26218137,1515,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +26218137,1516,,related to,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +7172075,1517,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +7172075,1518,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +26761340,1519,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +26761340,1520,,coexists with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +7782040,1521,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +12022213,1522,,physically interacts with,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +9512596,1523,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +19709381,1524,,affects,,Methoxsalen,,,,Deoxyribonucleic acid,,,,, +8674128,1525,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +8674128,1526,,coexists with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +8674127,1527,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +25732039,1528,,physically interacts with,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +16826513,1529,,affects,,Trioxsalen,,,,Deoxyribonucleic acid,,,,, +9717834,1530,,related to,,Bisoprolol,,,,hypertensive disorder,,,,, +17484309,1531,,affects,,Bisoprolol,,,,Hemorrhage,,,,, +14633716,1532,,affects,,Bisoprolol,,,,hypertensive disorder,,,,, +13150765,1533,,affects,,Bisoprolol,,,,pulmonary arterial hypertension,,,,, +24626572,1534,,disrupts,,Bisoprolol,,,,Hemorrhage,,,,, +23315135,1535,,prevents,,Bisoprolol,,,,Hemorrhage,,,,, +26817035,1536,,related to,,Esmolol,,,,atrial fibrillation,,,,, +13689489,1537,,causes,,Esmolol,,,,atrial fibrillation,,,,, +20072391,1538,,affects,,Esmolol,,,,toxic shock syndrome,,,,, +19519833,1539,,affects,,Esmolol,,,,Pain,,,,, +16877299,1540,,prevents,,Esmolol,,,,Pain,,,,, +10180097,1541,,prevents,,Esmolol,,,,ischemia reperfusion injury,,,,, +9581320,1542,,prevents,,Esmolol,,,,atrial fibrillation,,,,, +18235527,1543,,related to,,Oxygen,,,,pulmonary fibrosis,,,,, +18193743,1544,,related to,,Oxygen,,,,neoplasm,,,,, +17303485,1545,,related to,,Oxygen,,,,Hypoxemia,,,,, +14116536,1546,,related to,,Oxygen,,,,Shock,,,,, +13587155,1547,,related to,,Oxygen,,,,injury,,,,, +8813011,1548,,related to,,Oxygen,,,,ischemia reperfusion injury,,,,, +21893162,1549,,causes,,Oxygen,,,,neoplasm,,,,, +19992109,1550,,causes,,Oxygen,,,,ischemia reperfusion injury,,,,, +8243272,1551,,causes,,Oxygen,,,,vascular disorder,,,,, +8114891,1552,,causes,,Oxygen,,,,injury,,,,, +7992845,1553,,causes,,Oxygen,,,,Hypoxemia,,,,, +7752235,1554,,causes,,Oxygen,,,,stroke disorder,,,,, +23272853,1555,,affects,,Oxygen,,,,neoplasm,,,,, +22206348,1556,,affects,,Oxygen,,,,neoplasm,,,,, +19397332,1557,,affects,,Oxygen,,,,Hypoxemia,,,,, +13060611,1558,,affects,,Oxygen,,,,Shock,,,,, +13638133,1559,,produces,,Oxygen,,,,Hypoxemia,,,,, +13264427,1560,,produces,,Oxygen,,,,neoplasm,,,,, +12483211,1561,,disrupts,,Oxygen,,,,Hypoxemia,,,,, +11682185,1562,,disrupts,,Oxygen,,,,neoplasm,,,,, +16806319,1563,,prevents,,Oxygen,,,,injury,,,,, +17280500,1564,,predisposes,,Oxygen,,,,injury,,,,, +7575686,1565,,subclass of,,Metoprolol,,,,O-Demethylmetoprolol,,,,, +7575685,1566,,subclass of,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +27359356,1567,,related to,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +27639377,1568,,derives from,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +26548288,1569,,physically interacts with,,Metoprolol,,,,O-Demethylmetoprolol,,,,, +21656554,1570,,physically interacts with,,Metoprolol,,,,alpha-Hydroxymetoprolol,,,,, +27101524,1571,,causes,,Metoprolol,,,,ventricular tachycardia,,,,, +27101519,1572,,causes,,Metoprolol,,,,ventricular fibrillation,,,,, +20648435,1573,,causes,,Metoprolol,,,,cardiac rhythm disease,,,,, +14625318,1574,,causes,,Metoprolol,,,,hypertensive disorder,,,,, +19013861,1575,,affects,,Metoprolol,,,,obesity disorder,,,,, +17630974,1576,,affects,,Metoprolol,,,,coronary artery disorder,,,,, +17630973,1577,,affects,,Metoprolol,,,,atherosclerosis,,,,, +16547648,1578,,affects,,Metoprolol,,,,myocardial infarction,,,,, +12751741,1579,,affects,,Metoprolol,,,,cardiac rhythm disease,,,,, +11341339,1580,,affects,,Metoprolol,,,,hypertensive disorder,,,,, +16802112,1581,,disrupts,,Metoprolol,,,,atrial fibrillation,,,,, +14314818,1582,,disrupts,,Metoprolol,,,,atherosclerosis,,,,, +13648308,1583,,disrupts,,Metoprolol,,,,ventricular tachycardia,,,,, +12510783,1584,,disrupts,,Metoprolol,,,,cardiac rhythm disease,,,,, +16624344,1585,,prevents,,Metoprolol,,,,cardiac rhythm disease,,,,, +13530896,1586,,prevents,,Metoprolol,,,,myocardial infarction,,,,, +13366014,1587,,prevents,,Metoprolol,,,,hypertensive disorder,,,,, +13268090,1588,,prevents,,Metoprolol,,,,ventricular fibrillation,,,,, +9428080,1589,,prevents,,Metoprolol,,,,atrial fibrillation,,,,, +7236533,1590,,prevents,,Metoprolol,,,,atherosclerosis,,,,, +22663349,1591,,predisposes,,Metoprolol,,,,atrial fibrillation,,,,, +25990864,1592,,affects,,Acebutolol,,,,hypertensive disorder,,,,, +25995365,1593,,prevents,,Acebutolol,,,,hypertensive disorder,,,,, +24856753,1594,,affects,,Pretomanid,,,,multidrug-resistant tuberculosis,,,,, +17848125,1595,,related to,,Nitrogen,,,,chronic obstructive pulmonary disease,,,,, +15192685,1596,,related to,,Nitrogen,,,,ischemia reperfusion injury,,,,, +10505101,1597,,related to,,Nitrogen,,,,burn,,,,, +10425490,1598,,related to,,Nitrogen,,,,cystic fibrosis,,,,, +16934805,1599,,causes,,Nitrogen,,,,ischemia reperfusion injury,,,,, +13030867,1600,,affects,,Nitrogen,,,,ischemia reperfusion injury,,,,, +9020164,1601,,affects,,Nitrogen,,,,severe acute respiratory syndrome,,,,, +17493096,1602,,predisposes,,Nitrogen,,,,ischemia reperfusion injury,,,,, +25313239,1603,,related to,,Helium,,,,status asthmaticus,,,,, +12274245,1604,,related to,,Helium,,,,chronic obstructive pulmonary disease,,,,, +15248421,1605,,related to,,Carbon Dioxide,,,,Pain,,,,, +11844945,1606,,related to,,Carbon Dioxide,,,,sleep apnea syndrome,,,,, +10575797,1607,,related to,,Carbon Dioxide,,,,respiratory failure,,,,, +7620110,1608,,related to,,Carbon Dioxide,,,,panic disorder,,,,, +16671036,1609,,causes,,Carbon Dioxide,,,,panic disorder,,,,, +11038318,1610,,causes,,Carbon Dioxide,,,,respiratory failure,,,,, +20071308,1611,,affects,,Carbon Dioxide,,,,Pain,,,,, +15771768,1612,,affects,,Carbon Dioxide,,,,Pain,,,,, +15385933,1613,,affects,,Carbon Dioxide,,,,panic disorder,,,,, +14460813,1614,,affects,,Carbon Dioxide,,,,respiratory failure,,,,, +15294247,1615,,produces,,Carbon Dioxide,,,,respiratory failure,,,,, +11946282,1616,,disrupts,,Carbon Dioxide,,,,Pain,,,,, +17126447,1617,,predisposes,,Carbon Dioxide,,,,Pain,,,,, +11404382,1618,,predisposes,,Carbon Dioxide,,,,panic disorder,,,,, +7432027,1619,,predisposes,,Carbon Dioxide,,,,respiratory failure,,,,, +24776228,1620,,causes,,Ethambutol,,,,tuberculosis,,,,, +25946331,1621,,affects,,Ethambutol,,,,tuberculosis,,,,, +24875144,1622,,affects,,Ethambutol,,,,pulmonary tuberculosis,,,,, +25597027,1623,,disrupts,,Ethambutol,,,,tuberculosis,,,,, +18704735,1624,,prevents,,Ethambutol,,,,tuberculosis,,,,, +14472959,1625,,affects,,Pyrazinamide,,,,pulmonary tuberculosis,,,,, +10149898,1626,,affects,,Pyrazinamide,,,,tuberculosis,,,,, +8080030,1627,,prevents,,Pyrazinamide,,,,tuberculosis,,,,, +27556045,1628,,predisposes,,Pyrazinamide,,,,tuberculosis,,,,, +26376727,1629,,related to,,Androstanolone,,,,hypogonadism,,,,, +22807780,1630,,affects,,Androstanolone,,,,hypogonadism,,,,, +7261548,1631,,related to,,Nebivolol,,,,essential hypertension,,,,, +10251853,1632,,affects,,Nebivolol,,,,hypertensive disorder,,,,, +20026875,1633,,prevents,,Nebivolol,,,,cardiovascular disorder,,,,, +10251855,1634,,prevents,,Nebivolol,,,,hypertensive disorder,,,,, +11558481,1635,,exacerbates,,Nebivolol,,,,hypertensive disorder,,,,, +17527026,1636,,related to,,Landiolol,,,,atrial fibrillation,,,,, +14267268,1637,,affects,,Landiolol,,,,atrial fibrillation,,,,, +16074351,1638,,disrupts,,Landiolol,,,,atrial fibrillation,,,,, +21882778,1639,,prevents,,Landiolol,,,,cardiac rhythm disease,,,,, +14873276,1640,,prevents,,Landiolol,,,,atrial fibrillation,,,,, +20190145,1641,,predisposes,,Landiolol,,,,atrial fibrillation,,,,, +26530979,1642,,related to,,Oxandrolone,,,,nutritional disorder,,,,, +17138340,1643,,related to,,Oxandrolone,,,,Fanconi anemia,,,,, +12117784,1644,,related to,,Oxandrolone,,,,Turner syndrome,,,,, +11269262,1645,,related to,,Oxandrolone,,,,burn,,,,, +7561027,1646,,causes,,Cefepime,,,,toxic shock syndrome,,,,, +19437692,1647,,affects,,Cefepime,,,,bacterial infectious disease,,,,, +17947468,1648,,affects,,Cefepime,,,,infectious disease,,,,, +19800344,1649,,disrupts,,Cefepime,,,,infectious disease,,,,, +26336145,1650,,related to,,Hydrocortisone butyrate,,,,"dermatitis, atopic",,,,, +26243703,1651,,related to,,Hydrocortisone butyrate,,,,skin disorder,,,,, +25968096,1652,,related to,,Hydrocortisone butyrate,,,,psoriasis,,,,, +17603464,1653,,disrupts,,Hydrocortisone butyrate,,,,psoriasis,,,,, +9729745,1654,,related to,,Adapalene,,,,acne,,,,, +8571018,1655,,physically interacts with,,Adapalene,,,,Retinoic Acid Receptor,,,,, +13523825,1656,,related to,,Retinol,,,,eye disorder,,,,, +11015290,1657,,related to,,Retinol,,,,tuberculosis,,,,, +10457909,1658,,related to,,Retinol,,,,acne,,,,, +8518043,1659,,related to,,Retinol,,,,malaria,,,,, +8137103,1660,,related to,,Retinol,,,,vitamin A deficiency,,,,, +7807614,1661,,related to,,Retinol,,,,retinitis pigmentosa,,,,, +9304322,1662,,causes,,Retinol,,,,malaria,,,,, +27090494,1663,,affects,,Retinol,,,,diarrheal disease,,,,, +21959378,1664,,affects,,Retinol,,,,nutritional disorder,,,,, +17401879,1665,,affects,,Retinol,,,,tuberculosis,,,,, +17082512,1666,,affects,,Retinol,,,,acne,,,,, +12962972,1667,,affects,,Retinol,,,,eye disorder,,,,, +12534891,1668,,affects,,Retinol,,,,vitamin A deficiency,,,,, +11508263,1669,,affects,,Retinol,,,,diarrheal disease,,,,, +10941106,1670,,affects,,Retinol,,,,vitamin A deficiency,,,,, +22325993,1671,,produces,,Retinol,,,,Infection,,,,, +23772860,1672,,disrupts,,Retinol,,,,vitamin A deficiency,,,,, +12105339,1673,,disrupts,,Retinol,,,,diarrheal disease,,,,, +24823924,1674,,prevents,,Retinol,,,,Infection,,,,, +17332605,1675,,prevents,,Retinol,,,,malaria,,,,, +11445573,1676,,prevents,,Retinol,,,,nutritional disorder,,,,, +8153477,1677,,prevents,,Retinol,,,,diarrheal disease,,,,, +23860384,1678,,predisposes,,Retinol,,,,nutritional disorder,,,,, +19923430,1679,,predisposes,,Retinol,,,,malaria,,,,, +16391363,1680,,predisposes,,Retinol,,,,tuberculosis,,,,, +15050082,1681,,predisposes,,Retinol,,,,diarrheal disease,,,,, +9744244,1682,,predisposes,,Retinol,,,,vitamin A deficiency,,,,, +18962170,1683,,related to,,Isotretinoin,,,,neuroblastoma,,,,, +16229483,1684,,related to,,Isotretinoin,,,,brain cancer,,,,, +15225681,1685,,related to,,Isotretinoin,,,,acne,,,,, +14091563,1686,,related to,,Isotretinoin,,,,myelodysplastic syndrome,,,,, +9061344,1687,,related to,,Isotretinoin,,,,renal cell carcinoma,,,,, +11768316,1688,,physically interacts with,,Isotretinoin,,,,Retinoic Acid Receptor,,,,, +21199868,1689,,causes,,Isotretinoin,,,,neuroblastoma,,,,, +19803622,1690,,causes,,Isotretinoin,,,,acne,,,,, +19310397,1691,,causes,,Isotretinoin,,,,breast neoplasm,,,,, +13522698,1692,,causes,,Isotretinoin,,,,neoplasm,,,,, +23934527,1693,,affects,,Isotretinoin,,,,neoplasm,,,,, +20382078,1694,,affects,,Isotretinoin,,,,neuroblastoma,,,,, +15927367,1695,,affects,,Isotretinoin,,,,rosacea,,,,, +15330626,1696,,affects,,Isotretinoin,,,,acne,,,,, +11212975,1697,,affects,,Isotretinoin,,,,neoplasm,,,,, +9764204,1698,,affects,,Isotretinoin,,,,acne,,,,, +21476432,1699,,disrupts,,Isotretinoin,,,,neuroblastoma,,,,, +14724193,1700,,disrupts,,Isotretinoin,,,,neoplasm,,,,, +14863864,1701,,prevents,,Isotretinoin,,,,acne,,,,, +8312321,1702,,prevents,,Isotretinoin,,,,neoplasm,,,,, +15444114,1703,,exacerbates,,Isotretinoin,,,,ichthyosis,,,,, +15310461,1704,,predisposes,,Isotretinoin,,,,acne,,,,, +24593446,1705,,affects,,Trifarotene,,,,acne,,,,, +21448312,1706,,affects,,Atazanavir,,,,AIDS,,,,, +24947472,1707,,disrupts,,Atazanavir,,,,HIV infectious disease,,,,, +13198660,1708,,disrupts,,Atazanavir,,,,AIDS,,,,, +20253995,1709,,prevents,,Atazanavir,,,,AIDS,,,,, +8134603,1710,,affects,,Saquinavir,,,,HIV infectious disease,,,,, +16320598,1711,,disrupts,,Saquinavir,,,,viral infectious disease,,,,, +13198658,1712,,disrupts,,Saquinavir,,,,AIDS,,,,, +17107608,1713,,prevents,,Saquinavir,,,,HIV infectious disease,,,,, +12560548,1714,,prevents,,Indinavir,,,,viral infectious disease,,,,, +15113750,1715,,related to,,Ritonavir,,,,AIDS,,,,, +7566746,1716,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +7566746,1717,,related to,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +15583404,1718,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +15583404,1719,,coexists with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +11500913,1720,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +8329957,1721,,physically interacts with,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +8452370,1722,,causes,,Ritonavir,,,,AIDS,,,,, +21492333,1723,,affects,,Ritonavir,,,,neoplasm,,,,, +12140603,1724,,affects,,Ritonavir,,,,Insulin resistance,,,,, +9520105,1725,,affects,,Ritonavir,,,,HIV infectious disease,,,,, +7566745,1726,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +15873481,1727,,affects,,Ritonavir,,,,Cytochrome P-450 CYP3A,,,,, +21820102,1728,,disrupts,,Ritonavir,,,,Coronavinae infectious disease,,,,, +15656958,1729,,disrupts,,Ritonavir,,,,HIV infectious disease,,,,, +9520113,1730,,disrupts,,Ritonavir,,,,neoplasm,,,,, +22737012,1731,,prevents,,Ritonavir,,,,neoplasm,,,,, +10934319,1732,,prevents,,Ritonavir,,,,Kaposi's sarcoma,,,,, +12915909,1733,,causes,,Nelfinavir,,,,diarrheal disease,,,,, +19184628,1734,,affects,,Nelfinavir,,,,neoplasm,,,,, +16087478,1735,,affects,,Nelfinavir,,,,plasma cell myeloma,,,,, +11272488,1736,,affects,,Nelfinavir,,,,diarrheal disease,,,,, +10940786,1737,,affects,,Thiopental,,,,brain injury,,,,, +7790675,1738,,prevents,,Thiopental,,,,brain injury,,,,, +26262897,1739,,causes,,Pentobarbital,,,,insomnia,,,,, +25778415,1740,,affects,,Pentobarbital,,,,insomnia,,,,, +13642757,1741,,disrupts,,Pentobarbital,,,,status epilepticus,,,,, +23761012,1742,,prevents,,Amobarbital,,,,osteoarthritis,,,,, +26983984,1743,,causes,,Moxisylyte,,,,erectile dysfunction,,,,, +26385811,1744,,prevents,,Mepyramine,,,,allergic disease,,,,, +27140633,1745,,subclass of,,Promethazine,,,,Promethazine sulfoxide,,,,, +19124534,1746,,related to,,Promethazine,,,,Vomiting,,,,, +26252918,1747,,causes,,Promethazine,,,,Vomiting,,,,, +8157500,1748,,causes,,Promethazine,,,,depressive disorder,,,,, +19547748,1749,,affects,,Promethazine,,,,Vomiting,,,,, +12404928,1750,,affects,,Promethazine,,,,Pruritus,,,,, +10742218,1751,,affects,,Promethazine,,,,Nausea,,,,, +10228295,1752,,affects,,Promethazine,,,,central nervous system origin vertigo,,,,, +7912966,1753,,affects,,Promethazine,,,,Vomiting,,,,, +13616931,1754,,disrupts,,Promethazine,,,,Nausea,,,,, +17497020,1755,,prevents,,Promethazine,,,,central nervous system origin vertigo,,,,, +11541778,1756,,prevents,,Promethazine,,,,Pruritus,,,,, +7912965,1757,,prevents,,Promethazine,,,,Vomiting,,,,, +7912964,1758,,prevents,,Promethazine,,,,Nausea,,,,, +25750000,1759,,causes,,Clemastine,,,,urticaria,,,,, +25747466,1760,,affects,,Clemastine,,,,urticaria,,,,, +19433677,1761,,affects,,Clemastine,,,,Pruritus,,,,, +25634655,1762,,disrupts,,Clemastine,,,,urticaria,,,,, +24612586,1763,,prevents,,Clemastine,,,,urticaria,,,,, +17916924,1764,,prevents,,Clemastine,,,,dermatitis,,,,, +24699384,1765,,predisposes,,Clemastine,,,,allergic disease,,,,, +25081855,1766,,affects,,Tiapride,,,,Dopamine D2 Receptor,,,,, +19553406,1767,,causes,,Amisulpride,,,,schizophrenia,,,,, +9337142,1768,,causes,,Amisulpride,,,,psychotic disorder,,,,, +24415555,1769,,affects,,Amisulpride,,,,depressive disorder,,,,, +8493076,1770,,affects,,Amisulpride,,,,schizophrenia,,,,, +20532376,1771,,prevents,,Amisulpride,,,,Postoperative Nausea and Vomiting,,,,, +19821343,1772,,prevents,,Amisulpride,,,,Nausea,,,,, +11149280,1773,,physically interacts with,,Remoxipride,,,,Dopamine D2 Receptor,,,,, +9174370,1774,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, +24158881,1775,,affects,,Remoxipride,,,,Dopamine D2 Receptor,,,,, +20394421,1776,,affects,,Levosulpiride,,,,Dopamine D2 Receptor,,,,, +26880772,1777,,related to,,Nitroglycerin,,,,coronary artery disorder,,,,, +26139329,1778,,related to,,Nitroglycerin,,,,hypertensive disorder,,,,, +21173297,1779,,related to,,Nitroglycerin,,,,injury,,,,, +26585664,1780,,causes,,Nitroglycerin,,,,Raynaud disease,,,,, +26278376,1781,,causes,,Nitroglycerin,,,,Angina pectoris,,,,, +26148974,1782,,causes,,Nitroglycerin,,,,myocardial infarction,,,,, +15949436,1783,,causes,,Nitroglycerin,,,,injury,,,,, +15624022,1784,,causes,,Nitroglycerin,,,,Inflammation,,,,, +14985558,1785,,causes,,Nitroglycerin,,,,hypertensive disorder,,,,, +8402702,1786,,causes,,Nitroglycerin,,,,Pain,,,,, +7629693,1787,,causes,,Nitroglycerin,,,,hypotensive disorder,,,,, +26786108,1788,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, +26278652,1789,,affects,,Nitroglycerin,,,,hypotensive disorder,,,,, +25994904,1790,,affects,,Nitroglycerin,,,,Raynaud disease,,,,, +25747829,1791,,affects,,Nitroglycerin,,,,erectile dysfunction,,,,, +25260538,1792,,affects,,Nitroglycerin,,,,Muscle spasm,,,,, +23178151,1793,,affects,,Nitroglycerin,,,,coronary artery disorder,,,,, +20885558,1794,,affects,,Nitroglycerin,,,,injury,,,,, +18491008,1795,,affects,,Nitroglycerin,,,,Hot flashes,,,,, +14421188,1796,,affects,,Nitroglycerin,,,,Angina pectoris,,,,, +13478654,1797,,affects,,Nitroglycerin,,,,osteoporosis,,,,, +11707783,1798,,affects,,Nitroglycerin,,,,Pain,,,,, +11174035,1799,,affects,,Nitroglycerin,,,,hypertensive disorder,,,,, +10595566,1800,,affects,,Nitroglycerin,,,,stroke disorder,,,,, +8601510,1801,,affects,,Nitroglycerin,,,,myocardial ischemia,,,,, +8521770,1802,,affects,,Nitroglycerin,,,,phlebitis,,,,, +8049127,1803,,affects,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, +26813951,1804,,disrupts,,Nitroglycerin,,,,myocardial ischemia,,,,, +26590847,1805,,disrupts,,Nitroglycerin,,,,hypertensive disorder,,,,, +24386334,1806,,disrupts,,Nitroglycerin,,,,phlebitis,,,,, +19274234,1807,,disrupts,,Nitroglycerin,,,,injury,,,,, +10081147,1808,,disrupts,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, +9796564,1809,,disrupts,,Nitroglycerin,,,,Pain,,,,, +25569906,1810,,prevents,,Nitroglycerin,,,,phlebitis,,,,, +21983895,1811,,prevents,,Nitroglycerin,,,,Muscle spasm,,,,, +20473117,1812,,prevents,,Nitroglycerin,,,,Inflammation,,,,, +18491009,1813,,prevents,,Nitroglycerin,,,,Hot flashes,,,,, +17804368,1814,,prevents,,Nitroglycerin,,,,hypertensive disorder,,,,, +11496690,1815,,prevents,,Nitroglycerin,,,,ischemia reperfusion injury,,,,, +10695579,1816,,prevents,,Nitroglycerin,,,,Angina pectoris,,,,, +10573276,1817,,prevents,,Nitroglycerin,,,,myocardial infarction,,,,, +9096899,1818,,prevents,,Nitroglycerin,,,,Pain,,,,, +9057729,1819,,prevents,,Nitroglycerin,,,,Shock,,,,, +8235862,1820,,prevents,,Nitroglycerin,,,,Marchiafava-Bignami disease,,,,, +7713034,1821,,prevents,,Nitroglycerin,,,,injury,,,,, +13750741,1822,,exacerbates,,Nitroglycerin,,,,myocardial ischemia,,,,, +20483551,1823,,predisposes,,Nitroglycerin,,,,myocardial ischemia,,,,, +9897513,1824,,predisposes,,Nitroglycerin,,,,Angina pectoris,,,,, +20924645,1825,,related to,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, +10616906,1826,,related to,,Isosorbide dinitrate,,,,Angina pectoris,,,,, +9112334,1827,,related to,,Isosorbide dinitrate,,,,coronary artery disorder,,,,, +26334868,1828,,affects,,Isosorbide dinitrate,,,,Angina pectoris,,,,, +10884689,1829,,affects,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, +9112335,1830,,prevents,,Isosorbide dinitrate,,,,myocardial ischemia,,,,, +17782283,1831,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, +7084056,1832,,physically interacts with,,Sulpiride,,,,Dopamine D2 Receptor,,,,, +25690684,1833,,causes,,Sulpiride,,,,depressive disorder,,,,, +26343015,1834,,affects,,Sulpiride,,,,schizophrenia,,,,, +23882267,1835,,affects,,Sulpiride,,,,anxiety,,,,, +8960439,1836,,affects,,Sulpiride,,,,depressive disorder,,,,, +8364166,1837,,affects,,Sulpiride,,,,Dopamine D2 Receptor,,,,, +7538297,1838,,affects,,Sulpiride,,,,depressive disorder,,,,, +25756981,1839,,disrupts,,Sulpiride,,,,depressive disorder,,,,, +8859505,1840,,disrupts,,Sulpiride,,,,anxiety,,,,, +26753868,1841,,causes,,Isosorbide mononitrate,,,,Angina pectoris,,,,, +15856723,1842,,affects,,Isosorbide mononitrate,,,,Angina pectoris,,,,, +24979081,1843,,prevents,,Isosorbide mononitrate,,,,vascular disorder,,,,, +22319748,1844,,prevents,,Isosorbide mononitrate,,,,Angina pectoris,,,,, +23203614,1845,,related to,,Ribociclib,,,,squamous cell carcinoma,,,,, +23890460,1846,,related to,,Abemaciclib,,,,non-small cell lung carcinoma,,,,, +24133672,1847,,affects,,Abemaciclib,,,,neoplasm,,,,, +23820208,1848,,disrupts,,Abemaciclib,,,,neoplasm,,,,, +7114439,1849,,subclass of,,Sodium Chloride,,,,Electrolytes,,,,, +27178225,1850,,related to,,Sodium Chloride,,,,hypoglycemia,,,,, +26906663,1851,,related to,,Sodium Chloride,,,,ventricular septal defect,,,,, +26538206,1852,,related to,,Sodium Chloride,,,,papilloma,,,,, +26529472,1853,,related to,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, +26267091,1854,,related to,,Sodium Chloride,,,,Sepsis,,,,, +26209731,1855,,related to,,Sodium Chloride,,,,cataract,,,,, +25917183,1856,,related to,,Sodium Chloride,,,,Hypoxemia,,,,, +20673450,1857,,related to,,Sodium Chloride,,,,Alzheimer disease,,,,, +20617514,1858,,related to,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, +20321366,1859,,related to,,Sodium Chloride,,,,type 1 diabetes mellitus,,,,, +19962817,1860,,related to,,Sodium Chloride,,,,Inflammation,,,,, +19891172,1861,,related to,,Sodium Chloride,,,,acute lung injury,,,,, +19636264,1862,,related to,,Sodium Chloride,,,,ischemic disease,,,,, +19577743,1863,,related to,,Sodium Chloride,,,,spinal cord injury,,,,, +19497082,1864,,related to,,Sodium Chloride,,,,primary ciliary dyskinesia,,,,, +18975700,1865,,related to,,Sodium Chloride,,,,bacterial infectious disease,,,,, +18966398,1866,,related to,,Sodium Chloride,,,,osteoarthritis,,,,, +18860303,1867,,related to,,Sodium Chloride,,,,bone fracture,,,,, +18738706,1868,,related to,,Sodium Chloride,,,,toxic shock syndrome,,,,, +18679247,1869,,related to,,Sodium Chloride,,,,Electrolytes,,,,, +18617363,1870,,related to,,Sodium Chloride,,,,iron deficiency anemia,,,,, +18287282,1871,,related to,,Sodium Chloride,,,,Pruritus,,,,, +17603340,1872,,related to,,Sodium Chloride,,,,brain injury,,,,, +17533385,1873,,related to,,Sodium Chloride,,,,myocardial infarction,,,,, +17525035,1874,,related to,,Sodium Chloride,,,,coronary artery disorder,,,,, +17213013,1875,,related to,,Sodium Chloride,,,,hepatocellular carcinoma,,,,, +17202845,1876,,related to,,Sodium Chloride,,,,Parkinson disease,,,,, +16886803,1877,,related to,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +16594665,1878,,related to,,Sodium Chloride,,,,Pain,,,,, +16433967,1879,,related to,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, +15412515,1880,,related to,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, +14710472,1881,,related to,,Sodium Chloride,,,,bronchiolitis,,,,, +14037713,1882,,related to,,Sodium Chloride,,,,ventricular tachycardia,,,,, +13928740,1883,,related to,,Sodium Chloride,,,,pulmonary edema,,,,, +13375642,1884,,related to,,Sodium Chloride,,,,Insulin resistance,,,,, +13343201,1885,,related to,,Sodium Chloride,,,,Hypernatremia,,,,, +13277977,1886,,related to,,Sodium Chloride,,,,diabetic ketoacidosis,,,,, +11905993,1887,,related to,,Sodium Chloride,,,,depressive disorder,,,,, +11014479,1888,,related to,,Sodium Chloride,,,,glaucoma,,,,, +10966302,1889,,related to,,Sodium Chloride,,,,malaria,,,,, +10739226,1890,,related to,,Sodium Chloride,,,,heart disorder,,,,, +10689901,1891,,related to,,Sodium Chloride,,,,diabetes mellitus,,,,, +10566407,1892,,related to,,Sodium Chloride,,,,brain cancer,,,,, +10531148,1893,,related to,,Sodium Chloride,,,,kidney failure,,,,, +10510273,1894,,related to,,Sodium Chloride,,,,Shock,,,,, +10504585,1895,,related to,,Sodium Chloride,,,,tuberculosis,,,,, +10502982,1896,,related to,,Sodium Chloride,,,,nutritional disorder,,,,, +10502981,1897,,related to,,Sodium Chloride,,,,cirrhosis of liver,,,,, +10487095,1898,,related to,,Sodium Chloride,,,,pneumonia,,,,, +10439781,1899,,related to,,Sodium Chloride,,,,acute kidney failure,,,,, +10433628,1900,,related to,,Sodium Chloride,,,,psoriasis,,,,, +10370762,1901,,related to,,Sodium Chloride,,,,Hypothermia,,,,, +10318383,1902,,related to,,Sodium Chloride,,,,cardiovascular disorder,,,,, +10300324,1903,,related to,,Sodium Chloride,,,,stroke disorder,,,,, +10268953,1904,,related to,,Sodium Chloride,,,,brain edema,,,,, +9985623,1905,,related to,,Sodium Chloride,,,,Nausea,,,,, +9642141,1906,,related to,,Sodium Chloride,,,,obesity disorder,,,,, +9504754,1907,,related to,,Sodium Chloride,,,,asthma,,,,, +9350794,1908,,related to,,Sodium Chloride,,,,essential hypertension,,,,, +9217528,1909,,related to,,Sodium Chloride,,,,dry eye syndrome,,,,, +8489872,1910,,related to,,Sodium Chloride,,,,injury,,,,, +8486278,1911,,related to,,Sodium Chloride,,,,cystic fibrosis,,,,, +7822303,1912,,related to,,Sodium Chloride,,,,neoplasm,,,,, +7455347,1913,,related to,,Sodium Chloride,,,,Hypovolemia,,,,, +7397406,1914,,related to,,Sodium Chloride,,,,kidney disorder,,,,, +7259411,1915,,related to,,Sodium Chloride,,,,hypertensive disorder,,,,, +19769676,1916,,related to,,Sodium Chloride,,,,Electrolytes,,,,, +18679248,1917,,close match,,Sodium Chloride,,,,Electrolytes,,,,, +7792933,1918,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, +9181325,1919,,coexists with,,Sodium Chloride,,,,Electrolytes,,,,, +27223278,1920,,derives from,,Sodium Chloride,,,,Electrolytes,,,,, +9585905,1921,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, +9585904,1922,,physically interacts with,,Sodium Chloride,,,,Electrolytes,,,,, +26947391,1923,,causes,,Sodium Chloride,,,,acute kidney tubular necrosis,,,,, +26813055,1924,,causes,,Sodium Chloride,,,,Dyspnea,,,,, +26651944,1925,,causes,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, +26200221,1926,,causes,,Sodium Chloride,,,,melanoma,,,,, +25963723,1927,,causes,,Sodium Chloride,,,,cardiac arrest,,,,, +24999522,1928,,causes,,Sodium Chloride,,,,Nausea,,,,, +23507574,1929,,causes,,Sodium Chloride,,,,burn,,,,, +21365055,1930,,causes,,Sodium Chloride,,,,respiratory failure,,,,, +20716492,1931,,causes,,Sodium Chloride,,,,multiple organ dysfunction syndrome,,,,, +20666627,1932,,causes,,Sodium Chloride,,,,malaria,,,,, +20168868,1933,,causes,,Sodium Chloride,,,,fibromyalgia,,,,, +19652731,1934,,causes,,Sodium Chloride,,,,Chronic pain,,,,, +19581650,1935,,causes,,Sodium Chloride,,,,neoplasm,,,,, +19527177,1936,,causes,,Sodium Chloride,,,,liver and intrahepatic bile duct neoplasm,,,,, +19434783,1937,,causes,,Sodium Chloride,,,,Low back pain,,,,, +19352698,1938,,causes,,Sodium Chloride,,,,bone fracture,,,,, +19268574,1939,,causes,,Sodium Chloride,,,,ulcerative colitis,,,,, +18873789,1940,,causes,,Sodium Chloride,,,,preeclampsia,,,,, +18760766,1941,,causes,,Sodium Chloride,,,,heart disorder,,,,, +18419412,1942,,causes,,Sodium Chloride,,,,infertility disorder,,,,, +18184755,1943,,causes,,Sodium Chloride,,,,intervertebral disc degenerative disorder,,,,, +18174270,1944,,causes,,Sodium Chloride,,,,asthma,,,,, +17957169,1945,,causes,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, +17846702,1946,,causes,,Sodium Chloride,,,,cardiovascular disorder,,,,, +17472790,1947,,causes,,Sodium Chloride,,,,Postoperative Complications,,,,, +17050802,1948,,causes,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, +16922792,1949,,causes,,Sodium Chloride,,,,aortic aneurysm,,,,, +16902385,1950,,causes,,Sodium Chloride,,,,Hypoxemia,,,,, +16884655,1951,,causes,,Sodium Chloride,,,,obesity disorder,,,,, +15862216,1952,,causes,,Sodium Chloride,,,,Sepsis,,,,, +15183436,1953,,causes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +14507617,1954,,causes,,Sodium Chloride,,,,brain edema,,,,, +14335740,1955,,causes,,Sodium Chloride,,,,essential hypertension,,,,, +14100671,1956,,causes,,Sodium Chloride,,,,Cough,,,,, +13899816,1957,,causes,,Sodium Chloride,,,,brain injury,,,,, +13415978,1958,,causes,,Sodium Chloride,,,,rhinitis,,,,, +13156241,1959,,causes,,Sodium Chloride,,,,allergic disease,,,,, +12922926,1960,,causes,,Sodium Chloride,,,,periodontitis,,,,, +12796728,1961,,causes,,Sodium Chloride,,,,myocardial infarction,,,,, +12757253,1962,,causes,,Sodium Chloride,,,,urticaria,,,,, +12052924,1963,,causes,,Sodium Chloride,,,,Fever,,,,, +11367442,1964,,causes,,Sodium Chloride,,,,Hypothermia,,,,, +10844905,1965,,causes,,Sodium Chloride,,,,kidney disorder,,,,, +10703852,1966,,causes,,Sodium Chloride,,,,Ascites,,,,, +10680402,1967,,causes,,Sodium Chloride,,,,kidney failure,,,,, +10468869,1968,,causes,,Sodium Chloride,,,,Hyperhidrosis,,,,, +10303736,1969,,causes,,Sodium Chloride,,,,Hemorrhage,,,,, +10216492,1970,,causes,,Sodium Chloride,,,,Insulin resistance,,,,, +9649854,1971,,causes,,Sodium Chloride,,,,Inflammation,,,,, +9417058,1972,,causes,,Sodium Chloride,,,,stroke disorder,,,,, +9370401,1973,,causes,,Sodium Chloride,,,,acute kidney failure,,,,, +9311776,1974,,causes,,Sodium Chloride,,,,hypotensive disorder,,,,, +8912328,1975,,causes,,Sodium Chloride,,,,injury,,,,, +8760965,1976,,causes,,Sodium Chloride,,,,hyperinsulinism,,,,, +8723767,1977,,causes,,Sodium Chloride,,,,Hyponatremia,,,,, +8658207,1978,,causes,,Sodium Chloride,,,,ischemic disease,,,,, +8215909,1979,,causes,,Sodium Chloride,,,,type 2 diabetes mellitus,,,,, +7966995,1980,,causes,,Sodium Chloride,,,,Shock,,,,, +7871886,1981,,causes,,Sodium Chloride,,,,Hypernatremia,,,,, +7769838,1982,,causes,,Sodium Chloride,,,,Pain,,,,, +7535626,1983,,causes,,Sodium Chloride,,,,pulmonary edema,,,,, +7170398,1984,,causes,,Sodium Chloride,,,,cataract,,,,, +7067270,1985,,causes,,Sodium Chloride,,,,hypertensive disorder,,,,, +27640062,1986,,affects,,Sodium Chloride,,,,hyperinsulinism,,,,, +27459630,1987,,affects,,Sodium Chloride,,,,ischemic disease,,,,, +26883243,1988,,affects,,Sodium Chloride,,,,pulmonary edema,,,,, +25873721,1989,,affects,,Sodium Chloride,,,,stroke disorder,,,,, +25698961,1990,,affects,,Sodium Chloride,,,,Hypovolemia,,,,, +23350231,1991,,affects,,Sodium Chloride,,,,allergic disease,,,,, +21279163,1992,,affects,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, +19916489,1993,,affects,,Sodium Chloride,,,,malaria,,,,, +19654566,1994,,affects,,Sodium Chloride,,,,Fever,,,,, +19387644,1995,,affects,,Sodium Chloride,,,,Dyspnea,,,,, +19198162,1996,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, +19068195,1997,,affects,,Sodium Chloride,,,,Pain,,,,, +18857149,1998,,affects,,Sodium Chloride,,,,injury,,,,, +18063112,1999,,affects,,Sodium Chloride,,,,myocardial infarction,,,,, +17981225,2000,,affects,,Sodium Chloride,,,,Fever,,,,, +17956116,2001,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, +17749046,2002,,affects,,Sodium Chloride,,,,asthma,,,,, +17453252,2003,,affects,,Sodium Chloride,,,,Hyperhidrosis,,,,, +17320603,2004,,affects,,Sodium Chloride,,,,brain injury,,,,, +17252322,2005,,affects,,Sodium Chloride,,,,iron deficiency anemia,,,,, +17081119,2006,,affects,,Sodium Chloride,,,,cataract,,,,, +17021361,2007,,affects,,Sodium Chloride,,,,urticaria,,,,, +16829226,2008,,affects,,Sodium Chloride,,,,osteoarthritis,,,,, +16392979,2009,,affects,,Sodium Chloride,,,,Sepsis,,,,, +16339812,2010,,affects,,Sodium Chloride,,,,Inflammation,,,,, +16191401,2011,,affects,,Sodium Chloride,,,,Shock,,,,, +16150899,2012,,affects,,Sodium Chloride,,,,severe cutaneous adverse reaction,,,,, +15784044,2013,,affects,,Sodium Chloride,,,,Electrolytes,,,,, +15684126,2014,,affects,,Sodium Chloride,,,,malaria,,,,, +15518572,2015,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +15358630,2016,,affects,,Sodium Chloride,,,,brain injury,,,,, +14974493,2017,,affects,,Sodium Chloride,,,,cardiovascular disorder,,,,, +14875621,2018,,affects,,Sodium Chloride,,,,Hypoxemia,,,,, +14652078,2019,,affects,,Sodium Chloride,,,,preeclampsia,,,,, +14650670,2020,,affects,,Sodium Chloride,,,,Ascites,,,,, +14454543,2021,,affects,,Sodium Chloride,,,,Inflammation,,,,, +14269847,2022,,affects,,Sodium Chloride,,,,kidney disorder,,,,, +13713189,2023,,affects,,Sodium Chloride,,,,acute lung injury,,,,, +13361928,2024,,affects,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +13091031,2025,,affects,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +12113298,2026,,affects,,Sodium Chloride,,,,diabetes mellitus,,,,, +11936868,2027,,affects,,Sodium Chloride,,,,allergic disease,,,,, +11761266,2028,,affects,,Sodium Chloride,,,,stroke disorder,,,,, +11373059,2029,,affects,,Sodium Chloride,,,,Pain,,,,, +11352407,2030,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, +10762234,2031,,affects,,Sodium Chloride,,,,hypotensive disorder,,,,, +10689150,2032,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, +10555492,2033,,affects,,Sodium Chloride,,,,nutritional disorder,,,,, +10543207,2034,,affects,,Sodium Chloride,,,,myocarditis,,,,, +10409590,2035,,affects,,Sodium Chloride,,,,essential hypertension,,,,, +10373089,2036,,affects,,Sodium Chloride,,,,Hypernatremia,,,,, +10347664,2037,,affects,,Sodium Chloride,,,,neoplasm,,,,, +10303742,2038,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, +10216887,2039,,affects,,Sodium Chloride,,,,Shock,,,,, +10038950,2040,,affects,,Sodium Chloride,,,,injury,,,,, +9833746,2041,,affects,,Sodium Chloride,,,,obesity disorder,,,,, +9701968,2042,,affects,,Sodium Chloride,,,,brain edema,,,,, +9235049,2043,,affects,,Sodium Chloride,,,,Hyponatremia,,,,, +9211629,2044,,affects,,Sodium Chloride,,,,asthma,,,,, +8885675,2045,,affects,,Sodium Chloride,,,,Ascites,,,,, +8142503,2046,,affects,,Sodium Chloride,,,,Insulin resistance,,,,, +7538296,2047,,affects,,Sodium Chloride,,,,depressive disorder,,,,, +7487288,2048,,affects,,Sodium Chloride,,,,Hemorrhage,,,,, +7249676,2049,,affects,,Sodium Chloride,,,,Fever,,,,, +7189372,2050,,affects,,Sodium Chloride,,,,depressive disorder,,,,, +7186849,2051,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, +7146026,2052,,affects,,Sodium Chloride,,,,hypertensive disorder,,,,, +10370500,2053,,affects,,Sodium Chloride,,,,Electrolytes,,,,, +14010559,2054,,produces,,Sodium Chloride,,,,hypertensive disorder,,,,, +25864505,2055,,disrupts,,Sodium Chloride,,,,malaria,,,,, +19817939,2056,,disrupts,,Sodium Chloride,,,,chronic obstructive pulmonary disease,,,,, +19569177,2057,,disrupts,,Sodium Chloride,,,,anxiety,,,,, +19347835,2058,,disrupts,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +19339201,2059,,disrupts,,Sodium Chloride,,,,Cough,,,,, +18711875,2060,,disrupts,,Sodium Chloride,,,,pulmonary edema,,,,, +18638520,2061,,disrupts,,Sodium Chloride,,,,brain edema,,,,, +18394970,2062,,disrupts,,Sodium Chloride,,,,Inflammation,,,,, +17319016,2063,,disrupts,,Sodium Chloride,,,,dental caries,,,,, +17223012,2064,,disrupts,,Sodium Chloride,,,,hypertensive disorder,,,,, +17223011,2065,,disrupts,,Sodium Chloride,,,,cardiovascular disorder,,,,, +17009512,2066,,disrupts,,Sodium Chloride,,,,allergic disease,,,,, +13585452,2067,,disrupts,,Sodium Chloride,,,,neoplasm,,,,, +12586414,2068,,disrupts,,Sodium Chloride,,,,Hypoxemia,,,,, +12214170,2069,,disrupts,,Sodium Chloride,,,,injury,,,,, +10927798,2070,,disrupts,,Sodium Chloride,,,,stroke disorder,,,,, +8273399,2071,,disrupts,,Sodium Chloride,,,,Pain,,,,, +27207716,2072,,prevents,,Sodium Chloride,,,,periodontal disorder,,,,, +27075073,2073,,prevents,,Sodium Chloride,,,,subarachnoid hemorrhage,,,,, +23771600,2074,,prevents,,Sodium Chloride,,,,sinusitis,,,,, +21279166,2075,,prevents,,Sodium Chloride,,,,Postoperative Nausea and Vomiting,,,,, +20586429,2076,,prevents,,Sodium Chloride,,,,stroke disorder,,,,, +20472317,2077,,prevents,,Sodium Chloride,,,,myocardial infarction,,,,, +20150308,2078,,prevents,,Sodium Chloride,,,,Chronic pain,,,,, +20050861,2079,,prevents,,Sodium Chloride,,,,Dyspnea,,,,, +19622277,2080,,prevents,,Sodium Chloride,,,,Pruritus,,,,, +19347836,2081,,prevents,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +18643598,2082,,prevents,,Sodium Chloride,,,,ventricular tachycardia,,,,, +18145237,2083,,prevents,,Sodium Chloride,,,,Nausea,,,,, +17285701,2084,,prevents,,Sodium Chloride,,,,neuralgia,,,,, +17081118,2085,,prevents,,Sodium Chloride,,,,cataract,,,,, +16603496,2086,,prevents,,Sodium Chloride,,,,brain injury,,,,, +16427621,2087,,prevents,,Sodium Chloride,,,,diabetes mellitus,,,,, +16310359,2088,,prevents,,Sodium Chloride,,,,burn,,,,, +16010295,2089,,prevents,,Sodium Chloride,,,,ischemic disease,,,,, +15507954,2090,,prevents,,Sodium Chloride,,,,pulmonary arterial hypertension,,,,, +15307837,2091,,prevents,,Sodium Chloride,,,,acute lung injury,,,,, +15219283,2092,,prevents,,Sodium Chloride,,,,allergic disease,,,,, +14919203,2093,,prevents,,Sodium Chloride,,,,spinal cord injury,,,,, +14359710,2094,,prevents,,Sodium Chloride,,,,obesity disorder,,,,, +14313516,2095,,prevents,,Sodium Chloride,,,,Inflammation,,,,, +14313515,2096,,prevents,,Sodium Chloride,,,,ischemia reperfusion injury,,,,, +13297854,2097,,prevents,,Sodium Chloride,,,,kidney disorder,,,,, +12464836,2098,,prevents,,Sodium Chloride,,,,malaria,,,,, +12453134,2099,,prevents,,Sodium Chloride,,,,iron deficiency anemia,,,,, +12276610,2100,,prevents,,Sodium Chloride,,,,essential hypertension,,,,, +12092501,2101,,prevents,,Sodium Chloride,,,,hypertensive disorder,,,,, +11205687,2102,,prevents,,Sodium Chloride,,,,acute kidney failure,,,,, +10429352,2103,,prevents,,Sodium Chloride,,,,injury,,,,, +10205494,2104,,prevents,,Sodium Chloride,,,,Hypovolemia,,,,, +9628485,2105,,prevents,,Sodium Chloride,,,,anemia,,,,, +8227059,2106,,prevents,,Sodium Chloride,,,,Shock,,,,, +8196581,2107,,prevents,,Sodium Chloride,,,,dental caries,,,,, +8059428,2108,,prevents,,Sodium Chloride,,,,Pain,,,,, +22103068,2109,,exacerbates,,Sodium Chloride,,,,hypertensive disorder,,,,, +20308305,2110,,exacerbates,,Sodium Chloride,,,,Inflammation,,,,, +21816011,2111,,predisposes,,Sodium Chloride,,,,essential hypertension,,,,, +19774957,2112,,predisposes,,Sodium Chloride,,,,pulmonary edema,,,,, +18380691,2113,,predisposes,,Sodium Chloride,,,,myocardial infarction,,,,, +18041213,2114,,predisposes,,Sodium Chloride,,,,Inflammation,,,,, +16033022,2115,,predisposes,,Sodium Chloride,,,,injury,,,,, +13840593,2116,,predisposes,,Sodium Chloride,,,,allergic disease,,,,, +13808663,2117,,predisposes,,Sodium Chloride,,,,diabetes mellitus,,,,, +13731023,2118,,predisposes,,Sodium Chloride,,,,cardiovascular disorder,,,,, +12280034,2119,,predisposes,,Sodium Chloride,,,,neoplasm,,,,, +12079247,2120,,predisposes,,Sodium Chloride,,,,hypertensive disorder,,,,, +11776631,2121,,predisposes,,Sodium Chloride,,,,stroke disorder,,,,, +11266800,2122,,predisposes,,Sodium Chloride,,,,kidney disorder,,,,, +10118531,2123,,predisposes,,Sodium Chloride,,,,obesity disorder,,,,, +9111875,2124,,predisposes,,Sodium Chloride,,,,cardiac rhythm disease,,,,, +9647073,2125,,related to,,Dexpanthenol,,,,skin disorder,,,,, +26305399,2126,,affects,,Dexpanthenol,,,,Erythema,,,,, +25421467,2127,,prevents,,Dexpanthenol,,,,cheilitis,,,,, +24024712,2128,,related to,,ELTROMBOPAG,,,,autoimmune thrombocytopenic purpura,,,,, +22097814,2129,,related to,,ELTROMBOPAG,,,,acute myeloid leukemia,,,,, +22063304,2130,,related to,,ELTROMBOPAG,,,,aplastic anemia,,,,, +22063303,2131,,related to,,ELTROMBOPAG,,,,myelodysplastic syndrome,,,,, +22049758,2132,,related to,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +23835836,2133,,causes,,ELTROMBOPAG,,,,anemia,,,,, +22601227,2134,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +21709185,2135,,affects,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +22821304,2136,,prevents,,ELTROMBOPAG,,,,Hemorrhage,,,,, +22169266,2137,,prevents,,ELTROMBOPAG,,,,thrombocytopenia,,,,, +12546229,2138,,affects,,Etamsylate,,,,Hemorrhage,,,,, +9791897,2139,,affects,,Etamsylate,,,,Hemorrhage,,,,, +22608563,2140,,prevents,,Etamsylate,,,,Hemorrhage,,,,, +26536250,2141,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +26536250,2142,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +26158944,2143,,related to,,mitomycin C,,,,adenocarcinoma,,,,, +26111339,2144,,related to,,mitomycin C,,,,squamous cell carcinoma,,,,, +26043076,2145,,related to,,mitomycin C,,,,neoplasm,,,,, +25722815,2146,,related to,,mitomycin C,,,,leukemia,,,,, +12722759,2147,,related to,,mitomycin C,,,,carcinoma,,,,, +10467532,2148,,related to,,mitomycin C,,,,non-small cell lung carcinoma,,,,, +7255625,2149,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +7255625,2150,,related to,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8689799,2151,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8689799,2152,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8030161,2153,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8030161,2154,,coexists with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +7255626,2155,,physically interacts with,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +25769130,2156,,causes,,mitomycin C,,,,sarcoma,,,,, +25692678,2157,,causes,,mitomycin C,,,,hepatocellular carcinoma,,,,, +20975852,2158,,causes,,mitomycin C,,,,carcinoma,,,,, +12184177,2159,,causes,,mitomycin C,,,,Corneal opacity,,,,, +11626710,2160,,causes,,mitomycin C,,,,urethral stricture,,,,, +9485346,2161,,causes,,mitomycin C,,,,neoplasm,,,,, +26017044,2162,,affects,,mitomycin C,,,,squamous cell carcinoma,,,,, +25924198,2163,,affects,,mitomycin C,,,,adenocarcinoma,,,,, +24961205,2164,,affects,,mitomycin C,,,,neoplasm,,,,, +21183193,2165,,affects,,mitomycin C,,,,transitional cell carcinoma,,,,, +20995393,2166,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, +20865956,2167,,affects,,mitomycin C,,,,pterygium,,,,, +17166086,2168,,affects,,mitomycin C,,,,mesothelioma,,,,, +15342296,2169,,affects,,mitomycin C,,,,sclerosing cholangitis,,,,, +14897135,2170,,affects,,mitomycin C,,,,Corneal opacity,,,,, +14480408,2171,,affects,,mitomycin C,,,,liver and intrahepatic bile duct neoplasm,,,,, +14435862,2172,,affects,,mitomycin C,,,,Corneal opacity,,,,, +10146530,2173,,affects,,mitomycin C,,,,open-angle glaucoma,,,,, +8885108,2174,,affects,,mitomycin C,,,,urinary bladder neoplasm,,,,, +8612675,2175,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +8242643,2176,,affects,,mitomycin C,,,,neoplasm,,,,, +8428809,2177,,affects,,mitomycin C,,,,Deoxyribonucleic acid,,,,, +26926271,2178,,disrupts,,mitomycin C,,,,Neoplasm Metastasis,,,,, +21172443,2179,,disrupts,,mitomycin C,,,,urinary bladder neoplasm,,,,, +16608751,2180,,disrupts,,mitomycin C,,,,carcinoma,,,,, +12093037,2181,,disrupts,,mitomycin C,,,,neoplasm,,,,, +8920186,2182,,disrupts,,mitomycin C,,,,Corneal opacity,,,,, +22973529,2183,,prevents,,mitomycin C,,,,glaucoma,,,,, +19902018,2184,,prevents,,mitomycin C,,,,keratoconus,,,,, +19673685,2185,,prevents,,mitomycin C,,,,urethral stricture,,,,, +12959208,2186,,prevents,,mitomycin C,,,,Neoplasm Metastasis,,,,, +11642092,2187,,prevents,,mitomycin C,,,,Esophageal stenosis,,,,, +9925117,2188,,prevents,,mitomycin C,,,,neoplasm,,,,, +8410588,2189,,prevents,,mitomycin C,,,,pterygium,,,,, +7308263,2190,,prevents,,mitomycin C,,,,urinary bladder neoplasm,,,,, +20886584,2191,,predisposes,,mitomycin C,,,,neoplasm,,,,, +17638153,2192,,related to,,Cefazolin,,,,bone fracture,,,,, +20958121,2193,,causes,,Cefazolin,,,,bacterial infectious disease with sepsis,,,,, +25339548,2194,,affects,,Cefazolin,,,,obesity disorder,,,,, +27670629,2195,,prevents,,Cefazolin,,,,staphylococcal infection,,,,, +10537097,2196,,prevents,,Cefazolin,,,,bacterial infectious disease,,,,, +7415834,2197,,affects,,Famciclovir,,,,herpes zoster,,,,, +27310156,2198,,disrupts,,Famciclovir,,,,viral infectious disease,,,,, +11859744,2199,,disrupts,,Famciclovir,,,,herpes simplex infectious disease,,,,, +11859743,2200,,disrupts,,Famciclovir,,,,genital herpes,,,,, +7415831,2201,,prevents,,Famciclovir,,,,herpes zoster,,,,, +27248580,2202,,related to,,Acyclovir,,,,herpes zoster,,,,, +20916830,2203,,causes,,Acyclovir,,,,viral infectious disease,,,,, +21459205,2204,,affects,,Acyclovir,,,,herpes zoster,,,,, +17108497,2205,,affects,,Acyclovir,,,,genital herpes,,,,, +15677184,2206,,affects,,Acyclovir,,,,viral infectious disease,,,,, +9966648,2207,,affects,,Acyclovir,,,,chickenpox,,,,, +8137898,2208,,affects,,Acyclovir,,,,cytomegalovirus infection,,,,, +26100053,2209,,disrupts,,Acyclovir,,,,herpes zoster,,,,, +21196251,2210,,disrupts,,Acyclovir,,,,cytomegalovirus infection,,,,, +21045605,2211,,disrupts,,Acyclovir,,,,herpes simplex infectious disease,,,,, +13979845,2212,,disrupts,,Acyclovir,,,,HIV infectious disease,,,,, +11163493,2213,,disrupts,,Acyclovir,,,,chickenpox,,,,, +10081763,2214,,disrupts,,Acyclovir,,,,viral infectious disease,,,,, +8112053,2215,,disrupts,,Acyclovir,,,,genital herpes,,,,, +22220716,2216,,prevents,,Acyclovir,,,,chickenpox,,,,, +14453930,2217,,prevents,,Acyclovir,,,,herpes zoster,,,,, +11048138,2218,,prevents,,Acyclovir,,,,herpes labialis,,,,, +10652424,2219,,prevents,,Acyclovir,,,,viral infectious disease,,,,, +9977810,2220,,prevents,,Acyclovir,,,,genital herpes,,,,, +8973083,2221,,prevents,,Acyclovir,,,,cytomegalovirus infection,,,,, +8455850,2222,,prevents,,Acyclovir,,,,herpes simplex infectious disease,,,,, +16777411,2223,,predisposes,,Acyclovir,,,,herpes simplex infectious disease,,,,, +14602481,2224,,predisposes,,Acyclovir,,,,HIV infectious disease,,,,, +7066348,2225,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +7066348,2226,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +10786366,2227,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +10786366,2228,,coexists with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +15969143,2229,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +15969143,2230,,derives from,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +10765452,2231,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +8193345,2232,,physically interacts with,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +13332148,2233,,causes,,Idoxuridine,,,,viral infectious disease,,,,, +25762983,2234,,affects,,Idoxuridine,,,,viral infectious disease,,,,, +25024576,2235,,affects,,Idoxuridine,,,,Deoxyribonucleic acid,,,,, +25798138,2236,,affects,,Vidarabine,,,,herpes simplex infectious disease,,,,, +18005400,2237,,related to,,Ganciclovir,,,,AIDS,,,,, +11769089,2238,,related to,,Ganciclovir,,,,lymphoma,,,,, +7813894,2239,,causes,,Ganciclovir,,,,hepatocellular carcinoma,,,,, +21315977,2240,,affects,,Ganciclovir,,,,melanoma,,,,, +18696617,2241,,affects,,Ganciclovir,,,,viral infectious disease,,,,, +14018850,2242,,affects,,Ganciclovir,,,,graft versus host disease,,,,, +7745805,2243,,affects,,Ganciclovir,,,,hepatocellular carcinoma,,,,, +7264703,2244,,affects,,Ganciclovir,,,,retinitis,,,,, +7193112,2245,,affects,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, +27515973,2246,,disrupts,,Ganciclovir,,,,viral infectious disease,,,,, +20042666,2247,,disrupts,,Ganciclovir,,,,glioblastoma,,,,, +11829393,2248,,disrupts,,Ganciclovir,,,,cytomegalovirus infection,,,,, +9242712,2249,,disrupts,,Ganciclovir,,,,hepatocellular carcinoma,,,,, +27273103,2250,,prevents,,Ganciclovir,,,,retinitis,,,,, +14947813,2251,,prevents,,Ganciclovir,,,,viral infectious disease,,,,, +8898867,2252,,prevents,,Ganciclovir,,,,cytomegalovirus retinitis,,,,, +7606615,2253,,prevents,,Ganciclovir,,,,cytomegalovirus infection,,,,, +26756507,2254,,affects,,Nedocromil,,,,asthma,,,,, +12807968,2255,,affects,,Nedocromil,,,,asthma,,,,, +15773495,2256,,disrupts,,Nedocromil,,,,asthma,,,,, +26602335,2257,,prevents,,Nedocromil,,,,asthma,,,,, +25857910,2258,,related to,,Flumedroxone,,,,migraine disorder,,,,, +26456255,2259,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, +26456255,2260,,coexists with,,Valrubicin,,,,Deoxyribonucleic acid,,,,, +26331358,2261,,affects,,Valrubicin,,,,Deoxyribonucleic acid,,,,, +9013591,2262,,affects,,Valrubicin,,,,neoplasm,,,,, +15048973,2263,,disrupts,,Valrubicin,,,,neoplasm,,,,, +19780799,2264,,related to,,Idarubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +19123529,2265,,related to,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, +17160344,2266,,related to,,Idarubicin,,,,myelodysplastic syndrome,,,,, +13481436,2267,,related to,,Idarubicin,,,,acute myeloid leukemia,,,,, +12261572,2268,,related to,,Idarubicin,,,,plasma cell myeloma,,,,, +10347974,2269,,related to,,Idarubicin,,,,non-Hodgkin lymphoma,,,,, +8798925,2270,,related to,,Idarubicin,,,,acute promyelocytic leukemia,,,,, +17955637,2271,,causes,,Idarubicin,,,,acute myeloid leukemia,,,,, +10037923,2272,,causes,,Idarubicin,,,,neutropenia,,,,, +27637811,2273,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, +27582612,2274,,affects,,Idarubicin,,,,acute lymphoblastic leukemia,,,,, +27363552,2275,,affects,,Idarubicin,,,,neoplasm,,,,, +10133635,2276,,affects,,Idarubicin,,,,acute myeloid leukemia,,,,, +9755321,2277,,affects,,Idarubicin,,,,leukemia,,,,, +9560678,2278,,affects,,Idarubicin,,,,neoplasm,,,,, +9242996,2279,,affects,,Idarubicin,,,,neutropenia,,,,, +18342294,2280,,causes,,Pirarubicin,,,,neoplasm,,,,, +16182034,2281,,affects,,Pirarubicin,,,,neoplasm,,,,, +19153993,2282,,disrupts,,Pirarubicin,,,,neoplasm,,,,, +14778803,2283,,prevents,,Pirarubicin,,,,neoplasm,,,,, +20218174,2284,,subclass of,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, +25737166,2285,,related to,,Mitoxantrone,,,,lymphoma,,,,, +19961419,2286,,related to,,Mitoxantrone,,,,breast neoplasm,,,,, +14217137,2287,,related to,,Mitoxantrone,,,,mantle cell lymphoma,,,,, +13051364,2288,,related to,,Mitoxantrone,,,,multiple sclerosis,,,,, +8903075,2289,,related to,,Mitoxantrone,,,,acute myeloid leukemia,,,,, +8584278,2290,,causes,,Mitoxantrone,,,,acute myeloid leukemia,,,,, +26143277,2291,,affects,,Mitoxantrone,,,,lymphoma,,,,, +20218175,2292,,affects,,Mitoxantrone,,,,Mitoxantrone dicarboxylic acid,,,,, +11986455,2293,,affects,,Mitoxantrone,,,,multiple sclerosis,,,,, +9134230,2294,,prevents,,Mitoxantrone,,,,neoplasm,,,,, +11307631,2295,,exacerbates,,Mitoxantrone,,,,multiple sclerosis,,,,, +26844498,2296,,related to,,Doxorubicin,,,,renal cell carcinoma,,,,, +26506763,2297,,related to,,Doxorubicin,,,,Kaposi's sarcoma,,,,, +26097255,2298,,related to,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +25468576,2299,,related to,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, +21586070,2300,,related to,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, +17293414,2301,,related to,,Doxorubicin,,,,neoplasm,,,,, +14824461,2302,,related to,,Doxorubicin,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +12975330,2303,,related to,,Doxorubicin,,,,"Lymphoma, AIDS-Related",,,,, +12635005,2304,,related to,,Doxorubicin,,,,neuroendocrine neoplasm,,,,, +11664648,2305,,related to,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, +8248824,2306,,related to,,Doxorubicin,,,,lymphoma,,,,, +7897058,2307,,related to,,Doxorubicin,,,,leukemia,,,,, +7111309,2308,,related to,,Doxorubicin,,,,Hodgkins lymphoma,,,,, +26198671,2309,,causes,,Doxorubicin,,,,acute myeloid leukemia,,,,, +20905498,2310,,causes,,Doxorubicin,,,,prostate cancer,,,,, +19998968,2311,,causes,,Doxorubicin,,,,Hodgkins lymphoma,,,,, +17176693,2312,,causes,,Doxorubicin,,,,B-cell neoplasm,,,,, +16306119,2313,,causes,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +14936910,2314,,causes,,Doxorubicin,,,,plasma cell myeloma,,,,, +13613509,2315,,causes,,Doxorubicin,,,,sarcoma,,,,, +12176485,2316,,causes,,Doxorubicin,,,,"blast phase chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +12086573,2317,,causes,,Doxorubicin,,,,leukemia,,,,, +11480674,2318,,causes,,Doxorubicin,,,,Neoplasm Metastasis,,,,, +11088747,2319,,causes,,Doxorubicin,,,,neoplasm,,,,, +7374660,2320,,causes,,Doxorubicin,,,,neutropenia,,,,, +25410483,2321,,affects,,Doxorubicin,,,,glioma,,,,, +25202161,2322,,affects,,Doxorubicin,,,,glioblastoma,,,,, +24066270,2323,,affects,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, +23980169,2324,,affects,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, +20976248,2325,,affects,,Doxorubicin,,,,neuroblastoma,,,,, +20526631,2326,,affects,,Doxorubicin,,,,gastric neoplasm,,,,, +20464122,2327,,affects,,Doxorubicin,,,,T-cell non-Hodgkin lymphoma,,,,, +19907850,2328,,affects,,Doxorubicin,,,,renal cell carcinoma,,,,, +18966824,2329,,affects,,Doxorubicin,,,,leiomyosarcoma,,,,, +18841320,2330,,affects,,Doxorubicin,,,,B-cell chronic lymphocytic leukemia,,,,, +17410518,2331,,affects,,Doxorubicin,,,,rhabdomyosarcoma,,,,, +17166104,2332,,affects,,Doxorubicin,,,,mesothelioma,,,,, +17156749,2333,,affects,,Doxorubicin,,,,non-Hodgkin lymphoma,,,,, +17092174,2334,,affects,,Doxorubicin,,,,glioma,,,,, +16319458,2335,,affects,,Doxorubicin,,,,sarcoma,,,,, +15641121,2336,,affects,,Doxorubicin,,,,liver and intrahepatic bile duct neoplasm,,,,, +15592048,2337,,affects,,Doxorubicin,,,,diffuse large B-cell lymphoma,,,,, +15335028,2338,,affects,,Doxorubicin,,,,pancreatic ductal adenocarcinoma,,,,, +15288278,2339,,affects,,Doxorubicin,,,,mantle cell lymphoma,,,,, +15233880,2340,,affects,,Doxorubicin,,,,prostate cancer,,,,, +14862593,2341,,affects,,Doxorubicin,,,,liposarcoma,,,,, +13717435,2342,,affects,,Doxorubicin,,,,prostate cancer,,,,, +13641465,2343,,affects,,Doxorubicin,,,,Ewing sarcoma,,,,, +13641464,2344,,affects,,Doxorubicin,,,,bone osteosarcoma,,,,, +13477582,2345,,affects,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +12593977,2346,,affects,,Doxorubicin,,,,Kaposi's sarcoma,,,,, +12038917,2347,,affects,,Doxorubicin,,,,acute lymphoblastic leukemia,,,,, +11963770,2348,,affects,,Doxorubicin,,,,angiosarcoma,,,,, +11068243,2349,,affects,,Doxorubicin,,,,neutropenia,,,,, +9029101,2350,,affects,,Doxorubicin,,,,neoplasm,,,,, +7957058,2351,,affects,,Doxorubicin,,,,neoplasm,,,,, +7468708,2352,,affects,,Doxorubicin,,,,carcinoma,,,,, +7221748,2353,,affects,,Doxorubicin,,,,small cell lung carcinoma,,,,, +22415368,2354,,disrupts,,Doxorubicin,,,,glioma,,,,, +21775806,2355,,disrupts,,Doxorubicin,,,,non-small cell lung carcinoma,,,,, +19908932,2356,,disrupts,,Doxorubicin,,,,hematopoietic and lymphoid system neoplasm,,,,, +19216444,2357,,disrupts,,Doxorubicin,,,,lymphoma,,,,, +18593046,2358,,disrupts,,Doxorubicin,,,,bone osteosarcoma,,,,, +17338969,2359,,disrupts,,Doxorubicin,,,,melanoma,,,,, +15233882,2360,,disrupts,,Doxorubicin,,,,prostate cancer,,,,, +15026936,2361,,disrupts,,Doxorubicin,,,,B-cell neoplasm,,,,, +14123664,2362,,disrupts,,Doxorubicin,,,,hepatocellular carcinoma,,,,, +11529496,2363,,disrupts,,Doxorubicin,,,,neuroblastoma,,,,, +8800155,2364,,disrupts,,Doxorubicin,,,,neoplasm,,,,, +8316270,2365,,disrupts,,Doxorubicin,,,,Neoplasm Metastasis,,,,, +24403937,2366,,prevents,,Doxorubicin,,,,triple-negative breast carcinoma,,,,, +23195923,2367,,prevents,,Doxorubicin,,,,lung neoplasm,,,,, +22365593,2368,,prevents,,Doxorubicin,,,,leukemia,,,,, +15227703,2369,,prevents,,Doxorubicin,,,,sarcoma,,,,, +10708896,2370,,prevents,,Doxorubicin,,,,urinary bladder neoplasm,,,,, +8872024,2371,,prevents,,Doxorubicin,,,,Neoplasm Metastasis,,,,, +8737011,2372,,prevents,,Doxorubicin,,,,neutropenia,,,,, +7721507,2373,,prevents,,Doxorubicin,,,,neoplasm,,,,, +18908502,2374,,exacerbates,,Doxorubicin,,,,neoplasm,,,,, +25000938,2375,,predisposes,,Doxorubicin,,,,bone osteosarcoma,,,,, +20426915,2376,,predisposes,,Doxorubicin,,,,neoplasm,,,,, +19669792,2377,,predisposes,,Doxorubicin,,,,sarcoma,,,,, +18137816,2378,,predisposes,,Doxorubicin,,,,lymphoma,,,,, +12722667,2379,,predisposes,,Doxorubicin,,,,acute myeloid leukemia,,,,, +8803332,2380,,predisposes,,Doxorubicin,,,,kidney Wilms tumor,,,,, +7173827,2381,,predisposes,,Doxorubicin,,,,leukemia,,,,, +26966260,2382,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, +26966260,2383,,related to,,Iproniazid,,,,Monoamine Oxidase,,,,, +10565399,2384,,physically interacts with,,Iproniazid,,,,Monoamine Oxidase,,,,, +12902070,2385,,affects,,Iproniazid,,,,depressive disorder,,,,, +9833655,2386,,affects,,Iproniazid,,,,Monoamine Oxidase,,,,, +10498318,2387,,related to,,Epirubicin,,,,non-small cell lung carcinoma,,,,, +10228088,2388,,related to,,Epirubicin,,,,ovarian cancer,,,,, +10182077,2389,,related to,,Epirubicin,,,,non-Hodgkin lymphoma,,,,, +10182076,2390,,related to,,Epirubicin,,,,Hodgkins lymphoma,,,,, +8413603,2391,,related to,,Epirubicin,,,,small cell lung carcinoma,,,,, +7746533,2392,,related to,,Epirubicin,,,,castration-resistant prostate carcinoma,,,,, +26737878,2393,,physically interacts with,,Epirubicin,,,,7-Deoxydoxorubicinone,,,,, +18781215,2394,,causes,,Epirubicin,,,,neoplasm,,,,, +26736958,2395,,affects,,Epirubicin,,,,hepatocellular carcinoma,,,,, +12104701,2396,,affects,,Epirubicin,,,,neoplasm,,,,, +14784473,2397,,prevents,,Epirubicin,,,,neoplasm,,,,, +10544897,2398,,physically interacts with,,Nialamide,,,,Monoamine Oxidase,,,,, +9388429,2399,,affects,,Nialamide,,,,Monoamine Oxidase,,,,, +10646811,2400,,affects,,Isocarboxazid,,,,Monoamine Oxidase,,,,, +14451724,2401,,causes,,Valacyclovir,,,,psychotic disorder,,,,, +27205274,2402,,affects,,Valacyclovir,,,,postherpetic neuralgia,,,,, +25557382,2403,,affects,,Valacyclovir,,,,Pregnancy,,,,, +19384061,2404,,disrupts,,Valacyclovir,,,,herpes simplex infectious disease,,,,, +14963245,2405,,disrupts,,Valacyclovir,,,,herpes zoster,,,,, +10778326,2406,,disrupts,,Valacyclovir,,,,viral infectious disease,,,,, +10108851,2407,,disrupts,,Valacyclovir,,,,herpes labialis,,,,, +8112054,2408,,disrupts,,Valacyclovir,,,,genital herpes,,,,, +19368060,2409,,prevents,,Valacyclovir,,,,postherpetic neuralgia,,,,, +12346968,2410,,prevents,,Valacyclovir,,,,genital herpes,,,,, +10108849,2411,,prevents,,Valacyclovir,,,,herpes labialis,,,,, +9970234,2412,,prevents,,Valacyclovir,,,,herpes simplex infectious disease,,,,, +8018684,2413,,prevents,,Valacyclovir,,,,cytomegalovirus infection,,,,, +8899981,2414,,affects,,Cidofovir,,,,cytomegalovirus retinitis,,,,, +7346321,2415,,affects,,Cidofovir,,,,viral infectious disease,,,,, +11567412,2416,,disrupts,,Cidofovir,,,,cytomegalovirus infection,,,,, +27502123,2417,,prevents,,Cidofovir,,,,herpes simplex infectious disease,,,,, +16212718,2418,,prevents,,Cidofovir,,,,cytomegalovirus infection,,,,, +11248462,2419,,prevents,,Cidofovir,,,,viral infectious disease,,,,, +26922185,2420,,affects,,Penciclovir,,,,viral infectious disease,,,,, +22087736,2421,,affects,,Valganciclovir,,,,cytomegalovirus infection,,,,, +18756429,2422,,affects,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, +20121657,2423,,disrupts,,Valganciclovir,,,,cytomegalovirus infection,,,,, +12085189,2424,,prevents,,Valganciclovir,,,,sensorineural hearing loss disorder,,,,, +11282399,2425,,prevents,,Valganciclovir,,,,cytomegalovirus infection,,,,, +23156448,2426,,predisposes,,Valganciclovir,,,,kidney disorder,,,,, +20121656,2427,,predisposes,,Valganciclovir,,,,cytomegalovirus infection,,,,, +24607675,2428,,prevents,,Remdesivir,,,,adult acute respiratory distress syndrome,,,,, +18302878,2429,,related to,,Pixantrone,,,,Deoxyribonucleic acid,,,,, +19964229,2430,,affects,,Amrubicin,,,,small cell lung carcinoma,,,,, +15413207,2431,,disrupts,,Amrubicin,,,,neoplasm,,,,, +16523835,2432,,related to,,Sevoflurane,,,,delirium,,,,, +24969850,2433,,causes,,Sevoflurane,,,,adult acute respiratory distress syndrome,,,,, +24682900,2434,,causes,,Sevoflurane,,,,acute kidney failure,,,,, +18232524,2435,,causes,,Sevoflurane,,,,Inflammation,,,,, +17508909,2436,,causes,,Sevoflurane,,,,brain injury,,,,, +17459839,2437,,causes,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +11419059,2438,,causes,,Sevoflurane,,,,delirium,,,,, +7326848,2439,,causes,,Sevoflurane,,,,Pain,,,,, +25308865,2440,,affects,,Sevoflurane,,,,neoplasm,,,,, +25006055,2441,,affects,,Sevoflurane,,,,Pain,,,,, +21710900,2442,,affects,,Sevoflurane,,,,obesity disorder,,,,, +18602416,2443,,affects,,Sevoflurane,,,,delirium,,,,, +17685948,2444,,affects,,Sevoflurane,,,,Pain,,,,, +17508906,2445,,affects,,Sevoflurane,,,,brain injury,,,,, +13563816,2446,,affects,,Sevoflurane,,,,Inflammation,,,,, +7303814,2447,,affects,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +22571416,2448,,disrupts,,Sevoflurane,,,,myocardial infarction,,,,, +22138617,2449,,disrupts,,Sevoflurane,,,,brain injury,,,,, +19949689,2450,,disrupts,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +17977822,2451,,disrupts,,Sevoflurane,,,,Inflammation,,,,, +24348187,2452,,prevents,,Sevoflurane,,,,acute kidney failure,,,,, +24204877,2453,,prevents,,Sevoflurane,,,,neoplasm,,,,, +20028749,2454,,prevents,,Sevoflurane,,,,delirium,,,,, +19290567,2455,,prevents,,Sevoflurane,,,,Pain,,,,, +16830216,2456,,prevents,,Sevoflurane,,,,Inflammation,,,,, +11671117,2457,,prevents,,Sevoflurane,,,,brain injury,,,,, +9664903,2458,,prevents,,Sevoflurane,,,,ischemia reperfusion injury,,,,, +18320093,2459,,predisposes,,Sevoflurane,,,,delirium,,,,, +18121347,2460,,predisposes,,Sevoflurane,,,,Inflammation,,,,, +24455592,2461,,causes,,Desflurane,,,,Postoperative Complications,,,,, +16095968,2462,,related to,,Heroin,,,,heroin dependence,,,,, +9440915,2463,,related to,,Heroin,,,,opiate dependence,,,,, +18531996,2464,,causes,,Heroin,,,,heroin dependence,,,,, +14784390,2465,,causes,,Heroin,,,,opiate dependence,,,,, +19449218,2466,,related to,,Aluminum hydroxide,,,,type 1 diabetes mellitus,,,,, +19135529,2467,,related to,,Aluminum hydroxide,,,,malaria,,,,, +18758930,2468,,related to,,Aluminum hydroxide,,,,influenza,,,,, +15398111,2469,,prevents,,Aluminum hydroxide,,,,stomatitis,,,,, +15812884,2470,,related to,,Methadone,,,,heroin dependence,,,,, +19260564,2471,,causes,,Methadone,,,,neonatal abstinence syndrome,,,,, +18130331,2472,,causes,,Methadone,,,,neuralgia,,,,, +18100345,2473,,causes,,Methadone,,,,Pain,,,,, +21405277,2474,,affects,,Methadone,,,,opiate dependence,,,,, +21075382,2475,,affects,,Methadone,,,,neoplasm,,,,, +20010980,2476,,affects,,Methadone,,,,Premature birth,,,,, +18302283,2477,,affects,,Methadone,,,,Pain,,,,, +18207522,2478,,affects,,Methadone,,,,neonatal abstinence syndrome,,,,, +18078354,2479,,affects,,Methadone,,,,cocaine dependence,,,,, +11558529,2480,,affects,,Methadone,,,,HIV infectious disease,,,,, +9289228,2481,,affects,,Methadone,,,,HIV infectious disease,,,,, +8979183,2482,,affects,,Methadone,,,,neuralgia,,,,, +16059875,2483,,disrupts,,Methadone,,,,neonatal abstinence syndrome,,,,, +10769844,2484,,disrupts,,Methadone,,,,Pain,,,,, +17766557,2485,,prevents,,Methadone,,,,hepatitis C virus infection,,,,, +15264750,2486,,prevents,,Methadone,,,,opiate dependence,,,,, +8905283,2487,,prevents,,Methadone,,,,Pain,,,,, +8022918,2488,,prevents,,Methadone,,,,neonatal abstinence syndrome,,,,, +26487110,2489,,predisposes,,Methadone,,,,HIV infectious disease,,,,, +15424591,2490,,predisposes,,Methadone,,,,neonatal abstinence syndrome,,,,, +14491460,2491,,predisposes,,Methadone,,,,Premature birth,,,,, +26386166,2492,,causes,,Levomethadyl acetate,,,,opiate dependence,,,,, +26901861,2493,,prevents,,Halofantrine,,,,malaria,,,,, +27668107,2494,,related to,,Erythropoietin,,,,HIV infectious disease,,,,, +24695634,2495,,related to,,Erythropoietin,,,,optic nerve disorder,,,,, +21186290,2496,,related to,,Erythropoietin,,,,Premature birth,,,,, +20871066,2497,,related to,,Erythropoietin,,,,necrotizing enterocolitis,,,,, +18130124,2498,,related to,,Erythropoietin,,,,mood disorder,,,,, +17186873,2499,,related to,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, +16980950,2500,,related to,,Erythropoietin,,,,acute myeloid leukemia,,,,, +16468663,2501,,related to,,Erythropoietin,,,,optic neuritis,,,,, +16173384,2502,,related to,,Erythropoietin,,,,Friedreich ataxia,,,,, +15054484,2503,,related to,,Erythropoietin,,,,breast neoplasm,,,,, +14004775,2504,,related to,,Erythropoietin,,,,malaria,,,,, +13955435,2505,,related to,,Erythropoietin,,,,chronic renal failure syndrome,,,,, +13624052,2506,,related to,,Erythropoietin,,,,stroke disorder,,,,, +13580694,2507,,related to,,Erythropoietin,,,,Fatigue,,,,, +13206114,2508,,related to,,Erythropoietin,,,,sickle cell anemia,,,,, +12496787,2509,,related to,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, +12188394,2510,,related to,,Erythropoietin,,,,Parkinson disease,,,,, +12126135,2511,,related to,,Erythropoietin,,,,spinal cord injury,,,,, +11923140,2512,,related to,,Erythropoietin,,,,acute kidney failure,,,,, +11799479,2513,,related to,,Erythropoietin,,,,myocardial infarction,,,,, +11734187,2514,,related to,,Erythropoietin,,,,multiple sclerosis,,,,, +11580074,2515,,related to,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +11529882,2516,,related to,,Erythropoietin,,,,myocardial ischemia,,,,, +11452051,2517,,related to,,Erythropoietin,,,,prostate cancer,,,,, +11316441,2518,,related to,,Erythropoietin,,,,Ischemic stroke,,,,, +11293850,2519,,related to,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, +10879812,2520,,related to,,Erythropoietin,,,,hepatitis C virus infection,,,,, +10348029,2521,,related to,,Erythropoietin,,,,neoplasm,,,,, +9392178,2522,,related to,,Erythropoietin,,,,injury,,,,, +9089666,2523,,related to,,Erythropoietin,,,,chronic myelomonocytic leukemia,,,,, +8164061,2524,,related to,,Erythropoietin,,,,myelodysplastic syndrome,,,,, +7458321,2525,,related to,,Erythropoietin,,,,brain ischemia,,,,, +7310369,2526,,related to,,Erythropoietin,,,,anemia,,,,, +7231907,2527,,related to,,Erythropoietin,,,,chronic kidney disease,,,,, +7137476,2528,,related to,,Erythropoietin,,,,kidney failure,,,,, +12479345,2529,,has part,,Erythropoietin,,,,myelodysplastic syndrome,,,,, +9398172,2530,,has part,,Erythropoietin,,,,neoplasm,,,,, +27259307,2531,,causes,,Erythropoietin,,,,acute kidney failure,,,,, +20985522,2532,,causes,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +19282478,2533,,causes,,Erythropoietin,,,,neoplasm,,,,, +19178150,2534,,causes,,Erythropoietin,,,,spinal cord injury,,,,, +18508111,2535,,causes,,Erythropoietin,,,,Parkinson disease,,,,, +16355442,2536,,causes,,Erythropoietin,,,,brain ischemia,,,,, +15387266,2537,,causes,,Erythropoietin,,,,stroke disorder,,,,, +13935957,2538,,causes,,Erythropoietin,,,,injury,,,,, +12824447,2539,,causes,,Erythropoietin,,,,chronic kidney disease,,,,, +11912976,2540,,causes,,Erythropoietin,,,,myocardial infarction,,,,, +11763164,2541,,causes,,Erythropoietin,,,,Fatigue,,,,, +9672360,2542,,causes,,Erythropoietin,,,,kidney failure,,,,, +9370139,2543,,causes,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, +8009177,2544,,causes,,Erythropoietin,,,,anemia,,,,, +26962810,2545,,affects,,Erythropoietin,,,,HIV infectious disease,,,,, +26278974,2546,,affects,,Erythropoietin,,,,sickle cell anemia,,,,, +24983690,2547,,affects,,Erythropoietin,,,,acute myeloid leukemia,,,,, +20885392,2548,,affects,,Erythropoietin,,,,ST-elevation myocardial infarction,,,,, +20610677,2549,,affects,,Erythropoietin,,,,stroke disorder,,,,, +18390137,2550,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, +18352546,2551,,affects,,Erythropoietin,,,,injury,,,,, +17607901,2552,,affects,,Erythropoietin,,,,necrotizing enterocolitis,,,,, +15862945,2553,,affects,,Erythropoietin,,,,Ischemic stroke,,,,, +15862785,2554,,affects,,Erythropoietin,,,,malaria,,,,, +15728394,2555,,affects,,Erythropoietin,,,,myocardial infarction,,,,, +15532613,2556,,affects,,Erythropoietin,,,,myocardial infarction,,,,, +12937865,2557,,affects,,Erythropoietin,,,,anemia,,,,, +12867407,2558,,affects,,Erythropoietin,,,,myocardial ischemia,,,,, +11701568,2559,,affects,,Erythropoietin,,,,Fatigue,,,,, +11563361,2560,,affects,,Erythropoietin,,,,neoplasm,,,,, +10970912,2561,,affects,,Erythropoietin,,,,brain injury,,,,, +10068762,2562,,affects,,Erythropoietin,,,,injury,,,,, +9989127,2563,,affects,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +9392180,2564,,affects,,Erythropoietin,,,,spinal cord injury,,,,, +8981317,2565,,affects,,Erythropoietin,,,,brain ischemia,,,,, +7400221,2566,,affects,,Erythropoietin,,,,chronic kidney disease,,,,, +7278560,2567,,affects,,Erythropoietin,,,,anemia,,,,, +27259305,2568,,produces,,Erythropoietin,,,,acute kidney failure,,,,, +26811591,2569,,produces,,Erythropoietin,,,,HIV infectious disease,,,,, +26231858,2570,,produces,,Erythropoietin,,,,lymphoma,,,,, +14673419,2571,,produces,,Erythropoietin,,,,myocardial infarction,,,,, +11452049,2572,,produces,,Erythropoietin,,,,prostate cancer,,,,, +8829207,2573,,produces,,Erythropoietin,,,,neoplasm,,,,, +8032421,2574,,produces,,Erythropoietin,,,,chronic renal failure syndrome,,,,, +8032418,2575,,produces,,Erythropoietin,,,,chronic kidney disease,,,,, +7919214,2576,,produces,,Erythropoietin,,,,anemia,,,,, +7844664,2577,,produces,,Erythropoietin,,,,kidney failure,,,,, +17835656,2578,,disrupts,,Erythropoietin,,,,brain injury,,,,, +17602040,2579,,disrupts,,Erythropoietin,,,,Hemorrhage,,,,, +17384804,2580,,disrupts,,Erythropoietin,,,,Ischemic stroke,,,,, +15027834,2581,,disrupts,,Erythropoietin,,,,Fatigue,,,,, +13243471,2582,,disrupts,,Erythropoietin,,,,chronic kidney disease,,,,, +13033535,2583,,disrupts,,Erythropoietin,,,,amyotrophic lateral sclerosis,,,,, +11253087,2584,,disrupts,,Erythropoietin,,,,injury,,,,, +8818732,2585,,disrupts,,Erythropoietin,,,,anemia,,,,, +22124183,2586,,prevents,,Erythropoietin,,,,Premature birth,,,,, +19522952,2587,,prevents,,Erythropoietin,,,,Asphyxia,,,,, +17246645,2588,,prevents,,Erythropoietin,,,,cerebral palsy,,,,, +16915551,2589,,prevents,,Erythropoietin,,,,coronary artery disorder,,,,, +16468664,2590,,prevents,,Erythropoietin,,,,optic neuritis,,,,, +16040441,2591,,prevents,,Erythropoietin,,,,spinal cord injury,,,,, +15444373,2592,,prevents,,Erythropoietin,,,,Parkinson disease,,,,, +14252439,2593,,prevents,,Erythropoietin,,,,kidney failure,,,,, +13347324,2594,,prevents,,Erythropoietin,,,,subarachnoid hemorrhage,,,,, +13017739,2595,,prevents,,Erythropoietin,,,,chronic kidney disease,,,,, +11480928,2596,,prevents,,Erythropoietin,,,,Ischemic stroke,,,,, +11148609,2597,,prevents,,Erythropoietin,,,,myocardial ischemia,,,,, +11115141,2598,,prevents,,Erythropoietin,,,,stroke disorder,,,,, +10838253,2599,,prevents,,Erythropoietin,,,,necrotizing enterocolitis,,,,, +10766440,2600,,prevents,,Erythropoietin,,,,myocardial infarction,,,,, +10125087,2601,,prevents,,Erythropoietin,,,,ischemia reperfusion injury,,,,, +8434315,2602,,prevents,,Erythropoietin,,,,injury,,,,, +8405867,2603,,prevents,,Erythropoietin,,,,brain ischemia,,,,, +8369017,2604,,prevents,,Erythropoietin,,,,brain injury,,,,, +7400218,2605,,prevents,,Erythropoietin,,,,Fatigue,,,,, +7236347,2606,,prevents,,Erythropoietin,,,,anemia,,,,, +18610239,2607,,exacerbates,,Erythropoietin,,,,injury,,,,, +14126866,2608,,exacerbates,,Erythropoietin,,,,anemia,,,,, +25818939,2609,,predisposes,,Erythropoietin,,,,neoplasm,,,,, +19869298,2610,,predisposes,,Erythropoietin,,,,coronary artery disorder,,,,, +19564296,2611,,predisposes,,Erythropoietin,,,,Asphyxia,,,,, +19270398,2612,,predisposes,,Erythropoietin,,,,brain injury,,,,, +18282528,2613,,predisposes,,Erythropoietin,,,,chronic kidney disease,,,,, +16056103,2614,,predisposes,,Erythropoietin,,,,Ischemic stroke,,,,, +14483144,2615,,predisposes,,Erythropoietin,,,,injury,,,,, +12166360,2616,,predisposes,,Erythropoietin,,,,kidney failure,,,,, +8361116,2617,,predisposes,,Erythropoietin,,,,anemia,,,,, +24327196,2618,,affects,,Daprodustat,,,,anemia,,,,, +24574810,2619,,prevents,,Daprodustat,,,,anemia,,,,, +19595886,2620,,related to,,mecobalamin,,,,vitamin B12 deficiency,,,,, +13417310,2621,,related to,,mecobalamin,,,,amyotrophic lateral sclerosis,,,,, +26391120,2622,,related to,,vitamin B12,,,,myocardial infarction,,,,, +21860699,2623,,related to,,vitamin B12,,,,type 2 diabetes mellitus,,,,, +20662929,2624,,related to,,vitamin B12,,,,non-small cell lung carcinoma,,,,, +19346996,2625,,related to,,vitamin B12,,,,myocardial ischemia,,,,, +12974621,2626,,related to,,vitamin B12,,,,osteoporosis,,,,, +10934739,2627,,related to,,vitamin B12,,,,chronic kidney disease,,,,, +10883089,2628,,related to,,vitamin B12,,,,depressive disorder,,,,, +10658870,2629,,related to,,vitamin B12,,,,psoriasis,,,,, +10535786,2630,,related to,,vitamin B12,,,,atherosclerosis,,,,, +10535188,2631,,related to,,vitamin B12,,,,lymphoma,,,,, +10508686,2632,,related to,,vitamin B12,,,,vitamin B12 deficiency,,,,, +10438501,2633,,related to,,vitamin B12,,,,iron deficiency anemia,,,,, +9977774,2634,,related to,,vitamin B12,,,,psychotic disorder,,,,, +9644935,2635,,related to,,vitamin B12,,,,anemia,,,,, +9118739,2636,,related to,,vitamin B12,,,,Low back pain,,,,, +8678107,2637,,related to,,vitamin B12,,,,Alzheimer disease,,,,, +27330642,2638,,causes,,vitamin B12,,,,depressive disorder,,,,, +26003936,2639,,causes,,vitamin B12,,,,diabetic neuropathy,,,,, +17687811,2640,,causes,,vitamin B12,,,,osteoporosis,,,,, +11993792,2641,,causes,,vitamin B12,,,,Reduced blood folate concentration,,,,, +10806959,2642,,causes,,vitamin B12,,,,psychotic disorder,,,,, +10716413,2643,,causes,,vitamin B12,,,,vitamin B12 deficiency,,,,, +9828196,2644,,causes,,vitamin B12,,,,anemia,,,,, +7900732,2645,,causes,,vitamin B12,,,,atherosclerosis,,,,, +25091008,2646,,affects,,vitamin B12,,,,HIV infectious disease,,,,, +20098295,2647,,affects,,vitamin B12,,,,depressive disorder,,,,, +19763864,2648,,affects,,vitamin B12,,,,Alzheimer disease,,,,, +18490813,2649,,affects,,vitamin B12,,,,depressive disorder,,,,, +17348852,2650,,affects,,vitamin B12,,,,vitamin B12 deficiency,,,,, +16930257,2651,,affects,,vitamin B12,,,,amyotrophic lateral sclerosis,,,,, +13607058,2652,,affects,,vitamin B12,,,,depressive disorder,,,,, +12773836,2653,,affects,,vitamin B12,,,,atherosclerosis,,,,, +11945900,2654,,affects,,vitamin B12,,,,Pregnancy,,,,, +11927611,2655,,affects,,vitamin B12,,,,diabetic neuropathy,,,,, +10798681,2656,,affects,,vitamin B12,,,,type 2 diabetes mellitus,,,,, +10424959,2657,,affects,,vitamin B12,,,,anemia,,,,, +8733280,2658,,affects,,vitamin B12,,,,Pregnancy,,,,, +8015838,2659,,affects,,vitamin B12,,,,chronic kidney disease,,,,, +23636866,2660,,produces,,vitamin B12,,,,vitamin B12 deficiency,,,,, +11124683,2661,,disrupts,,vitamin B12,,,,chronic kidney disease,,,,, +20603701,2662,,prevents,,vitamin B12,,,,Alzheimer disease,,,,, +14586818,2663,,prevents,,vitamin B12,,,,anemia,,,,, +10782972,2664,,prevents,,vitamin B12,,,,atherosclerosis,,,,, +9545669,2665,,prevents,,vitamin B12,,,,vitamin B12 deficiency,,,,, +27415421,2666,,predisposes,,vitamin B12,,,,myocardial infarction,,,,, +21063265,2667,,predisposes,,vitamin B12,,,,depressive disorder,,,,, +20875915,2668,,predisposes,,vitamin B12,,,,chronic kidney disease,,,,, +15081186,2669,,predisposes,,vitamin B12,,,,osteoporosis,,,,, +12678935,2670,,predisposes,,vitamin B12,,,,atherosclerosis,,,,, +12664527,2671,,predisposes,,vitamin B12,,,,Alzheimer disease,,,,, +8590188,2672,,predisposes,,vitamin B12,,,,anemia,,,,, +22149451,2673,,affects,,Ipragliflozin,,,,type 2 diabetes mellitus,,,,, +24120079,2674,,disrupts,,Ertugliflozin,,,,diabetes mellitus,,,,, +23006843,2675,,related to,,Empagliflozin,,,,diabetes mellitus,,,,, +22183651,2676,,related to,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, +24924157,2677,,causes,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, +23515975,2678,,causes,,Empagliflozin,,,,myocardial infarction,,,,, +23240834,2679,,causes,,Empagliflozin,,,,acute kidney failure,,,,, +25094844,2680,,affects,,Empagliflozin,,,,diabetes mellitus,,,,, +24520517,2681,,affects,,Empagliflozin,,,,Insulin resistance,,,,, +24184835,2682,,affects,,Empagliflozin,,,,diabetic kidney disease,,,,, +24091231,2683,,affects,,Empagliflozin,,,,kidney disorder,,,,, +22935616,2684,,affects,,Empagliflozin,,,,non-alcoholic fatty liver disease,,,,, +22175650,2685,,affects,,Empagliflozin,,,,acute kidney failure,,,,, +22027265,2686,,affects,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, +21867589,2687,,affects,,Empagliflozin,,,,myocardial infarction,,,,, +21618629,2688,,affects,,Empagliflozin,,,,pulmonary arterial hypertension,,,,, +22842915,2689,,disrupts,,Empagliflozin,,,,type 2 diabetes mellitus,,,,, +23528682,2690,,prevents,,Empagliflozin,,,,myocardial infarction,,,,, +23286446,2691,,prevents,,Empagliflozin,,,,acute kidney failure,,,,, +24551007,2692,,predisposes,,Empagliflozin,,,,acute kidney failure,,,,, +24497752,2693,,predisposes,,Empagliflozin,,,,hypoglycemia,,,,, +23163444,2694,,predisposes,,Empagliflozin,,,,diabetic kidney disease,,,,, +21786786,2695,,related to,,Dapagliflozin,,,,Alzheimer disease,,,,, +23582915,2696,,causes,,Dapagliflozin,,,,Weight loss,,,,, +25156234,2697,,affects,,Dapagliflozin,,,,non-alcoholic fatty liver disease,,,,, +23530734,2698,,affects,,Dapagliflozin,,,,Albuminuria,,,,, +23107287,2699,,affects,,Dapagliflozin,,,,type 1 diabetes mellitus,,,,, +23072376,2700,,affects,,Dapagliflozin,,,,ischemia reperfusion injury,,,,, +22916804,2701,,affects,,Dapagliflozin,,,,diabetic kidney disease,,,,, +22845588,2702,,affects,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, +22578057,2703,,affects,,Dapagliflozin,,,,Albuminuria,,,,, +22163310,2704,,affects,,Dapagliflozin,,,,Weight loss,,,,, +21622453,2705,,affects,,Dapagliflozin,,,,atrial fibrillation,,,,, +25362847,2706,,disrupts,,Dapagliflozin,,,,acute kidney failure,,,,, +23258105,2707,,disrupts,,Dapagliflozin,,,,kidney failure,,,,, +22845589,2708,,disrupts,,Dapagliflozin,,,,diabetes mellitus,,,,, +23973238,2709,,prevents,,Dapagliflozin,,,,type 2 diabetes mellitus,,,,, +23528684,2710,,prevents,,Dapagliflozin,,,,myocardial infarction,,,,, +23138841,2711,,prevents,,Dapagliflozin,,,,diabetic kidney disease,,,,, +22845590,2712,,prevents,,Dapagliflozin,,,,diabetes mellitus,,,,, +22832530,2713,,prevents,,Dapagliflozin,,,,kidney failure,,,,, +21513723,2714,,prevents,,Dapagliflozin,,,,obesity disorder,,,,, +25236689,2715,,predisposes,,Dapagliflozin,,,,kidney failure,,,,, +23072379,2716,,predisposes,,Dapagliflozin,,,,myocardial infarction,,,,, +20833370,2717,,related to,,Methyldopa,,,,type 1 diabetes mellitus,,,,, +15433400,2718,,related to,,Methyldopa,,,,preeclampsia,,,,, +7364754,2719,,related to,,Methyldopa,,,,hypertensive disorder,,,,, +25805913,2720,,causes,,Methyldopa,,,,hypertensive disorder,,,,, +23430063,2721,,causes,,Methyldopa,,,,preeclampsia,,,,, +26257846,2722,,affects,,Methyldopa,,,,hypertensive disorder,,,,, +10671192,2723,,affects,,Methyldopa,,,,hypertensive disorder,,,,, +26170425,2724,,prevents,,Methyldopa,,,,hypertensive disorder,,,,, +8219214,2725,,exacerbates,,Methyldopa,,,,hypertensive disorder,,,,, +20611289,2726,,predisposes,,Methyldopa,,,,preeclampsia,,,,, +19343164,2727,,related to,,Exemestane,,,,male breast carcinoma,,,,, +14849934,2728,,related to,,Exemestane,,,,ductal breast carcinoma in situ,,,,, +14694867,2729,,related to,,Exemestane,,,,non-small cell lung carcinoma,,,,, +11511167,2730,,related to,,Exemestane,,,,neoplasm,,,,, +18732584,2731,,affects,,Exemestane,,,,neoplasm,,,,, +14063167,2732,,affects,,Exemestane,,,,neoplasm,,,,, +16053578,2733,,prevents,,Exemestane,,,,breast neoplasm,,,,, +20235097,2734,,disrupts,,Rivizor,,,,neoplasm,,,,, +24226617,2735,,related to,,Letrozole,,,,polycystic ovary syndrome,,,,, +19925368,2736,,related to,,Letrozole,,,,infertility disorder,,,,, +13004646,2737,,related to,,Letrozole,,,,endometriosis,,,,, +11511165,2738,,related to,,Letrozole,,,,neoplasm,,,,, +22485512,2739,,causes,,Letrozole,,,,infertility disorder,,,,, +17708157,2740,,causes,,Letrozole,,,,neoplasm,,,,, +14659251,2741,,causes,,Letrozole,,,,endometriosis,,,,, +11078418,2742,,causes,,Letrozole,,,,polycystic ovary syndrome,,,,, +10282160,2743,,causes,,Letrozole,,,,hypogonadism,,,,, +25205942,2744,,affects,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, +18870552,2745,,affects,,Letrozole,,,,Pregnancy,,,,, +18835925,2746,,affects,,Letrozole,,,,inflammatory breast carcinoma,,,,, +10866444,2747,,affects,,Letrozole,,,,Pregnancy,,,,, +7871182,2748,,affects,,Letrozole,,,,neoplasm,,,,, +21352213,2749,,disrupts,,Letrozole,,,,Pregnancy,,,,, +25448977,2750,,prevents,,Letrozole,,,,prostate cancer,,,,, +19305611,2751,,prevents,,Letrozole,,,,Spontaneous abortion,,,,, +17892609,2752,,prevents,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, +13373696,2753,,prevents,,Letrozole,,,,neoplasm,,,,, +20363763,2754,,predisposes,,Letrozole,,,,ovarian hyperstimulation syndrome,,,,, +19305612,2755,,predisposes,,Letrozole,,,,Spontaneous abortion,,,,, +26765214,2756,,affects,,Formestane,,,,neoplasm,,,,, +25526748,2757,,disrupts,,Formestane,,,,neoplasm,,,,, +13022860,2758,,prevents,,Formestane,,,,neoplasm,,,,, +26325498,2759,,affects,,Aminoglutethimide,,,,neoplasm,,,,, +12185634,2760,,affects,,Aminoglutethimide,,,,neoplasm,,,,, +22275813,2761,,related to,,Relugolix,,,,prostate cancer,,,,, +23469407,2762,,prevents,,Relugolix,,,,Pain,,,,, +25422975,2763,,related to,,Abiraterone,,,,castration-resistant prostate carcinoma,,,,, +20717678,2764,,related to,,Abiraterone,,,,prostate cancer,,,,, +16721978,2765,,affects,,Abiraterone,,,,prostate cancer,,,,, +15794241,2766,,prevents,,Abiraterone,,,,neoplasm,,,,, +19010753,2767,,predisposes,,Abiraterone,,,,prostate cancer,,,,, +11344546,2768,,related to,,Finasteride,,,,acne,,,,, +11344545,2769,,related to,,Finasteride,,,,alopecia,,,,, +9840638,2770,,related to,,Finasteride,,,,prostate cancer,,,,, +7359591,2771,,related to,,Finasteride,,,,benign prostatic hyperplasia,,,,, +21759063,2772,,causes,,Finasteride,,,,benign prostatic hyperplasia,,,,, +11694493,2773,,causes,,Finasteride,,,,prostate cancer,,,,, +11326933,2774,,affects,,Finasteride,,,,prostate cancer,,,,, +9873046,2775,,affects,,Finasteride,,,,benign prostatic hyperplasia,,,,, +9845785,2776,,affects,,Finasteride,,,,alopecia,,,,, +7857572,2777,,affects,,Finasteride,,,,prostate cancer,,,,, +21155186,2778,,disrupts,,Finasteride,,,,benign prostatic hyperplasia,,,,, +10949204,2779,,disrupts,,Finasteride,,,,prostate cancer,,,,, +7931250,2780,,disrupts,,Finasteride,,,,alopecia,,,,, +11279550,2781,,prevents,,Finasteride,,,,benign prostatic hyperplasia,,,,, +8938663,2782,,prevents,,Finasteride,,,,alopecia,,,,, +7857569,2783,,prevents,,Finasteride,,,,prostate cancer,,,,, +9840634,2784,,predisposes,,Finasteride,,,,prostate cancer,,,,, +8913536,2785,,predisposes,,Finasteride,,,,benign prostatic hyperplasia,,,,, +15677403,2786,,related to,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +14665250,2787,,related to,,Dutasteride,,,,prostate cancer,,,,, +22506276,2788,,causes,,Dutasteride,,,,prostatitis,,,,, +14995448,2789,,affects,,Dutasteride,,,,prostate cancer,,,,, +11407079,2790,,affects,,Dutasteride,,,,prostatitis,,,,, +10333399,2791,,affects,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +15838005,2792,,disrupts,,Dutasteride,,,,prostate cancer,,,,, +16876475,2793,,prevents,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +13018366,2794,,prevents,,Dutasteride,,,,alopecia,,,,, +12506526,2795,,prevents,,Dutasteride,,,,prostate cancer,,,,, +13749427,2796,,predisposes,,Dutasteride,,,,benign prostatic hyperplasia,,,,, +13628345,2797,,predisposes,,Dutasteride,,,,prostate cancer,,,,, +23122900,2798,,related to,,Celecoxib,,,,Pain,,,,, +20821764,2799,,related to,,Celecoxib,,,,prostate cancer,,,,, +14485082,2800,,related to,,Celecoxib,,,,castration-resistant prostate carcinoma,,,,, +14288130,2801,,related to,,Celecoxib,,,,neoplasm,,,,, +15210658,2802,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, +15210658,2803,,related to,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11056859,2804,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11056859,2805,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +19664582,2806,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +19664582,2807,,coexists with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +8460221,2808,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +9140190,2809,,physically interacts with,,Celecoxib,,,,Cyclooxygenase 2,,,,, +22101111,2810,,causes,,Celecoxib,,,,Alzheimer disease,,,,, +21110777,2811,,causes,,Celecoxib,,,,schizophrenia,,,,, +20555672,2812,,causes,,Celecoxib,,,,hepatocellular carcinoma,,,,, +14478589,2813,,causes,,Celecoxib,,,,Inflammation,,,,, +14396158,2814,,causes,,Celecoxib,,,,neoplasm,,,,, +13894212,2815,,causes,,Celecoxib,,,,peptic ulcer disease,,,,, +13829410,2816,,causes,,Celecoxib,,,,Pain,,,,, +12882318,2817,,causes,,Celecoxib,,,,colorectal neoplasm,,,,, +12147702,2818,,causes,,Celecoxib,,,,osteoarthritis,,,,, +12029200,2819,,causes,,Celecoxib,,,,Hemorrhage,,,,, +10018014,2820,,causes,,Celecoxib,,,,hypertensive disorder,,,,, +25555760,2821,,affects,,Celecoxib,,,,postpartum depression,,,,, +21116356,2822,,affects,,Celecoxib,,,,major depressive disorder,,,,, +19634803,2823,,affects,,Celecoxib,,,,Hemorrhage,,,,, +18087191,2824,,affects,,Celecoxib,,,,breast neoplasm,,,,, +17669654,2825,,affects,,Celecoxib,,,,glioma,,,,, +17634409,2826,,affects,,Celecoxib,,,,depressive disorder,,,,, +16787676,2827,,affects,,Celecoxib,,,,hypertensive disorder,,,,, +15889622,2828,,affects,,Celecoxib,,,,osteoarthritis,,,,, +13667242,2829,,affects,,Celecoxib,,,,obesity disorder,,,,, +13414910,2830,,affects,,Celecoxib,,,,Hemorrhage,,,,, +13122831,2831,,affects,,Celecoxib,,,,hypertensive disorder,,,,, +12419082,2832,,affects,,Celecoxib,,,,neoplasm,,,,, +11947530,2833,,affects,,Celecoxib,,,,hepatocellular carcinoma,,,,, +11444192,2834,,affects,,Celecoxib,,,,neoplasm,,,,, +11303331,2835,,affects,,Celecoxib,,,,non-small cell lung carcinoma,,,,, +10337670,2836,,affects,,Celecoxib,,,,colorectal neoplasm,,,,, +10157341,2837,,affects,,Celecoxib,,,,injury,,,,, +9967873,2838,,affects,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +9574485,2839,,affects,,Celecoxib,,,,schizophrenia,,,,, +9038473,2840,,affects,,Celecoxib,,,,peptic ulcer disease,,,,, +7841958,2841,,affects,,Celecoxib,,,,rheumatoid arthritis,,,,, +7726669,2842,,affects,,Celecoxib,,,,Pain,,,,, +7726668,2843,,affects,,Celecoxib,,,,Inflammation,,,,, +7264055,2844,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11464194,2845,,affects,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11846592,2846,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, +11846592,2847,,produces,,Celecoxib,,,,Cyclooxygenase 2,,,,, +14865798,2848,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, +14865798,2849,,has input,,Celecoxib,,,,Cyclooxygenase 2,,,,, +22029254,2850,,disrupts,,Celecoxib,,,,major depressive disorder,,,,, +16862201,2851,,disrupts,,Celecoxib,,,,hepatocellular carcinoma,,,,, +15337601,2852,,disrupts,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +15029907,2853,,disrupts,,Celecoxib,,,,Pain,,,,, +14234726,2854,,disrupts,,Celecoxib,,,,adenoma,,,,, +12025752,2855,,disrupts,,Celecoxib,,,,colonic neoplasm,,,,, +9589598,2856,,disrupts,,Celecoxib,,,,neoplasm,,,,, +9384934,2857,,disrupts,,Celecoxib,,,,breast neoplasm,,,,, +8528907,2858,,disrupts,,Celecoxib,,,,Inflammation,,,,, +19393781,2859,,prevents,,Celecoxib,,,,stroke disorder,,,,, +18309561,2860,,prevents,,Celecoxib,,,,hepatocellular carcinoma,,,,, +17468664,2861,,prevents,,Celecoxib,,,,non-small cell lung carcinoma,,,,, +16386169,2862,,prevents,,Celecoxib,,,,actinic keratosis,,,,, +16323754,2863,,prevents,,Celecoxib,,,,hypertensive disorder,,,,, +15947575,2864,,prevents,,Celecoxib,,,,osteoarthritis,,,,, +15337603,2865,,prevents,,Celecoxib,,,,Palmar-plantar erythrodysesthesia syndrome,,,,, +14688780,2866,,prevents,,Celecoxib,,,,Low back pain,,,,, +13346756,2867,,prevents,,Celecoxib,,,,prostate cancer,,,,, +12969778,2868,,prevents,,Celecoxib,,,,neuroblastoma,,,,, +12687466,2869,,prevents,,Celecoxib,,,,adenoma,,,,, +11060421,2870,,prevents,,Celecoxib,,,,classic familial adenomatous polyposis,,,,, +10931690,2871,,prevents,,Celecoxib,,,,breast neoplasm,,,,, +10337661,2872,,prevents,,Celecoxib,,,,colorectal neoplasm,,,,, +9969498,2873,,prevents,,Celecoxib,,,,Acute Pain,,,,, +9525867,2874,,prevents,,Celecoxib,,,,injury,,,,, +9508533,2875,,prevents,,Celecoxib,,,,Pain,,,,, +8844228,2876,,prevents,,Celecoxib,,,,Inflammation,,,,, +7720173,2877,,prevents,,Celecoxib,,,,neoplasm,,,,, +14426267,2878,,predisposes,,Celecoxib,,,,Inflammation,,,,, +12799788,2879,,predisposes,,Celecoxib,,,,hypertensive disorder,,,,, +11130431,2880,,predisposes,,Celecoxib,,,,injury,,,,, +12352394,2881,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +12352394,2882,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +14685035,2883,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +14685035,2884,,related to,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +8460222,2885,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +9140191,2886,,physically interacts with,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +10265772,2887,,causes,,Rofecoxib,,,,Pain,,,,, +13140649,2888,,affects,,Rofecoxib,,,,Pain,,,,, +13143485,2889,,affects,,Rofecoxib,,,,osteoarthritis,,,,, +12129893,2890,,affects,,Rofecoxib,,,,adenoma,,,,, +11539323,2891,,affects,,Rofecoxib,,,,Pain,,,,, +10337671,2892,,affects,,Rofecoxib,,,,colorectal neoplasm,,,,, +8436303,2893,,affects,,Rofecoxib,,,,osteoarthritis,,,,, +7546790,2894,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +11143316,2895,,affects,,Rofecoxib,,,,Cyclooxygenase 2,,,,, +11899486,2896,,disrupts,,Rofecoxib,,,,Pain,,,,, +12422414,2897,,prevents,,Rofecoxib,,,,adenoma,,,,, +10337662,2898,,prevents,,Rofecoxib,,,,colorectal neoplasm,,,,, +9488144,2899,,prevents,,Rofecoxib,,,,Pain,,,,, +12808149,2900,,predisposes,,Rofecoxib,,,,adenoma,,,,, +21440548,2901,,affects,,Etoricoxib,,,,osteoarthritis,,,,, +17783506,2902,,affects,,Etoricoxib,,,,injury,,,,, +15015650,2903,,affects,,Etoricoxib,,,,Pain,,,,, +13276651,2904,,affects,,Etoricoxib,,,,rheumatic disorder,,,,, +8656381,2905,,affects,,Etoricoxib,,,,Cyclooxygenase 2,,,,, +21271381,2906,,prevents,,Etoricoxib,,,,osteoarthritis,,,,, +17783508,2907,,prevents,,Etoricoxib,,,,injury,,,,, +13679347,2908,,prevents,,Etoricoxib,,,,Pain,,,,, +11619190,2909,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +11619190,2910,,coexists with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +17164065,2911,,physically interacts with,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +13276652,2912,,affects,,Lumiracoxib,,,,rheumatic disorder,,,,, +10245332,2913,,affects,,Lumiracoxib,,,,Cyclooxygenase 2,,,,, +13077914,2914,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, +11476053,2915,,physically interacts with,,Valdecoxib,,,,Cyclooxygenase 2,,,,, +9552647,2916,,affects,,Valdecoxib,,,,Cyclooxygenase 2,,,,, +11215677,2917,,disrupts,,Valdecoxib,,,,Pain,,,,, +15156435,2918,,prevents,,Valdecoxib,,,,pancreatitis,,,,, +10035578,2919,,prevents,,Valdecoxib,,,,Pain,,,,, +17909160,2920,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, +17909160,2921,,coexists with,,Parecoxib,,,,Cyclooxygenase 2,,,,, +16597136,2922,,affects,,Parecoxib,,,,Shoulder pain,,,,, +13492238,2923,,affects,,Parecoxib,,,,Pain,,,,, +12600950,2924,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, +18579418,2925,,affects,,Parecoxib,,,,Cyclooxygenase 2,,,,, +18207264,2926,,disrupts,,Parecoxib,,,,Pain,,,,, +16597135,2927,,prevents,,Parecoxib,,,,Shoulder pain,,,,, +14081775,2928,,prevents,,Parecoxib,,,,Pain,,,,, +22281663,2929,,related to,,Drospirenone,,,,polycystic ovary syndrome,,,,, +21546756,2930,,related to,,Drospirenone,,,,acne,,,,, +20964606,2931,,predisposes,,Drospirenone,,,,polycystic ovary syndrome,,,,, +8455182,2932,,related to,,Ropinirole,,,,Parkinson disease,,,,, +17774585,2933,,causes,,Ropinirole,,,,Parkinson disease,,,,, +14587825,2934,,affects,,Ropinirole,,,,Parkinson disease,,,,, +11791368,2935,,affects,,Ropinirole,,,,restless legs syndrome,,,,, +9334943,2936,,disrupts,,Ropinirole,,,,Parkinson disease,,,,, +10286489,2937,,prevents,,Ropinirole,,,,Parkinson disease,,,,, +27727471,2938,,related to,,Pergolide,,,,Parkinson disease,,,,, +11914502,2939,,causes,,Pergolide,,,,Parkinson disease,,,,, +10881399,2940,,affects,,Pergolide,,,,Parkinson disease,,,,, +16163315,2941,,related to,,Bromocriptine,,,,Parkinson disease,,,,, +15233295,2942,,related to,,Bromocriptine,,,,type 1 diabetes mellitus,,,,, +17352665,2943,,causes,,Bromocriptine,,,,obesity disorder,,,,, +12630193,2944,,causes,,Bromocriptine,,,,Parkinson disease,,,,, +22488533,2945,,affects,,Bromocriptine,,,,adenomyosis,,,,, +20888778,2946,,affects,,Bromocriptine,,,,Parkinson disease,,,,, +27647530,2947,,prevents,,Bromocriptine,,,,obesity disorder,,,,, +15529387,2948,,prevents,,Bromocriptine,,,,ovarian hyperstimulation syndrome,,,,, +18216941,2949,,causes,,Piribedil,,,,Parkinson disease,,,,, +8408670,2950,,affects,,Piribedil,,,,Parkinson disease,,,,, +8818724,2951,,related to,,Apomorphine,,,,Parkinson disease,,,,, +23018637,2952,,causes,,Apomorphine,,,,erectile dysfunction,,,,, +11364291,2953,,causes,,Apomorphine,,,,Parkinson disease,,,,, +8320181,2954,,affects,,Apomorphine,,,,Parkinson disease,,,,, +16869339,2955,,related to,,Cabergoline,,,,Parkinson disease,,,,, +19536611,2956,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, +15320456,2957,,physically interacts with,,Cabergoline,,,,Dopamine D2 Receptor,,,,, +20751353,2958,,causes,,Cabergoline,,,,endometriosis,,,,, +26585560,2959,,affects,,Cabergoline,,,,pituitary tumor,,,,, +19237315,2960,,affects,,Cabergoline,,,,endometriosis,,,,, +17463083,2961,,affects,,Cabergoline,,,,Dopamine D2 Receptor,,,,, +12695381,2962,,affects,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, +13380476,2963,,prevents,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, +9194241,2964,,predisposes,,Cabergoline,,,,ovarian hyperstimulation syndrome,,,,, +15982499,2965,,related to,,Pramipexole,,,,restless legs syndrome,,,,, +9735890,2966,,related to,,Pramipexole,,,,Parkinson disease,,,,, +21401262,2967,,causes,,Pramipexole,,,,restless legs syndrome,,,,, +15033700,2968,,causes,,Pramipexole,,,,obsessive-compulsive disorder,,,,, +13328857,2969,,causes,,Pramipexole,,,,Parkinson disease,,,,, +18143671,2970,,affects,,Pramipexole,,,,depressive disorder,,,,, +12990655,2971,,affects,,Pramipexole,,,,restless legs syndrome,,,,, +12579916,2972,,affects,,Pramipexole,,,,depressive disorder,,,,, +10881401,2973,,affects,,Pramipexole,,,,Parkinson disease,,,,, +11457313,2974,,prevents,,Pramipexole,,,,Parkinson disease,,,,, +24610805,2975,,affects,,Rotigotine,,,,Parkinson disease,,,,, +10840977,2976,,subclass of,,Norethindrone,,,,Norethindrone acetate,,,,, +8232443,2977,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, +11686400,2978,,related to,,Norethindrone,,,,Norethindrone acetate,,,,, +9474851,2979,,coexists with,,Norethindrone,,,,Norethindrone acetate,,,,, +9781055,2980,,physically interacts with,,Norethindrone,,,,Norethindrone acetate,,,,, +21462883,2981,,causes,,Norethindrone,,,,neoplasm,,,,, +27429354,2982,,affects,,Pramocaine,,,,Pruritus,,,,, +19275366,2983,,disrupts,,Miconazole,,,,fungal infectious disease,,,,, +26511975,2984,,prevents,,Miconazole,,,,fungal infectious disease,,,,, +26530559,2985,,affects,,Benzocaine,,,,Pain,,,,, +8870493,2986,,disrupts,,Benzocaine,,,,Pain,,,,, +8870496,2987,,prevents,,Benzocaine,,,,Pain,,,,, +25561815,2988,,related to,,Folic Acid,,,,systemic lupus erythematosus,,,,, +23703706,2989,,related to,,Folic Acid,,,,neoplasm of esophagus,,,,, +23248765,2990,,related to,,Folic Acid,,,,chronic renal failure syndrome,,,,, +20038856,2991,,related to,,Folic Acid,,,,psychotic disorder,,,,, +19346997,2992,,related to,,Folic Acid,,,,myocardial ischemia,,,,, +19301020,2993,,related to,,Folic Acid,,,,type 2 diabetes mellitus,,,,, +19114314,2994,,related to,,Folic Acid,,,,tuberculosis,,,,, +18323097,2995,,related to,,Folic Acid,,,,HIV infectious disease,,,,, +17591518,2996,,related to,,Folic Acid,,,,infertility disorder,,,,, +15826430,2997,,related to,,Folic Acid,,,,male infertility,,,,, +14280104,2998,,related to,,Folic Acid,,,,myocardial infarction,,,,, +12974622,2999,,related to,,Folic Acid,,,,osteoporosis,,,,, +12112288,3000,,related to,,Folic Acid,,,,autism spectrum disorder,,,,, +11305980,3001,,related to,,Folic Acid,,,,cleft palate,,,,, +10745702,3002,,related to,,Folic Acid,,,,malaria,,,,, +10717915,3003,,related to,,Folic Acid,,,,habitual spontaneous abortion,,,,, +10644755,3004,,related to,,Folic Acid,,,,atherosclerosis,,,,, +10226420,3005,,related to,,Folic Acid,,,,cervical polyp,,,,, +10177078,3006,,related to,,Folic Acid,,,,colorectal neoplasm,,,,, +10046990,3007,,related to,,Folic Acid,,,,depressive disorder,,,,, +9815747,3008,,related to,,Folic Acid,,,,hypertensive disorder,,,,, +9628243,3009,,related to,,Folic Acid,,,,mesothelioma,,,,, +9628242,3010,,related to,,Folic Acid,,,,non-small cell lung carcinoma,,,,, +9060030,3011,,related to,,Folic Acid,,,,neoplasm,,,,, +8875457,3012,,related to,,Folic Acid,,,,lymphoma,,,,, +8584638,3013,,related to,,Folic Acid,,,,sickle cell anemia,,,,, +8274471,3014,,related to,,Folic Acid,,,,chronic kidney disease,,,,, +8259960,3015,,related to,,Folic Acid,,,,type 1 diabetes mellitus,,,,, +8078141,3016,,related to,,Folic Acid,,,,Alzheimer disease,,,,, +7868306,3017,,related to,,Folic Acid,,,,coronary artery disorder,,,,, +7765942,3018,,related to,,Folic Acid,,,,anemia,,,,, +7303518,3019,,related to,,Folic Acid,,,,epilepsy,,,,, +7234301,3020,,related to,,Folic Acid,,,,Reduced blood folate concentration,,,,, +7229825,3021,,related to,,Folic Acid,,,,iron deficiency anemia,,,,, +7175279,3022,,related to,,Folic Acid,,,,rheumatoid arthritis,,,,, +25522909,3023,,causes,,Folic Acid,,,,diabetic kidney disease,,,,, +18689556,3024,,causes,,Folic Acid,,,,Alzheimer disease,,,,, +17559847,3025,,causes,,Folic Acid,,,,iron deficiency anemia,,,,, +17044072,3026,,causes,,Folic Acid,,,,depressive disorder,,,,, +15826434,3027,,causes,,Folic Acid,,,,male infertility,,,,, +15057448,3028,,causes,,Folic Acid,,,,chronic kidney disease,,,,, +14954987,3029,,causes,,Folic Acid,,,,autism spectrum disorder,,,,, +13825749,3030,,causes,,Folic Acid,,,,cleft lip,,,,, +13656973,3031,,causes,,Folic Acid,,,,neoplasm,,,,, +12212539,3032,,causes,,Folic Acid,,,,lymphoma,,,,, +11472417,3033,,causes,,Folic Acid,,,,gingival overgrowth,,,,, +11073752,3034,,causes,,Folic Acid,,,,myocardial ischemia,,,,, +10016854,3035,,causes,,Folic Acid,,,,hypertensive disorder,,,,, +8671948,3036,,causes,,Folic Acid,,,,cleft palate,,,,, +8640403,3037,,causes,,Folic Acid,,,,epilepsy,,,,, +7900734,3038,,causes,,Folic Acid,,,,coronary artery disorder,,,,, +7900729,3039,,causes,,Folic Acid,,,,atherosclerosis,,,,, +7637475,3040,,causes,,Folic Acid,,,,Reduced blood folate concentration,,,,, +7460069,3041,,causes,,Folic Acid,,,,anemia,,,,, +7392389,3042,,causes,,Folic Acid,,,,neural tube defect,,,,, +27400709,3043,,affects,,Folic Acid,,,,coronary artery disorder,,,,, +27350602,3044,,affects,,Folic Acid,,,,cleft palate,,,,, +26684582,3045,,affects,,Folic Acid,,,,colorectal neoplasm,,,,, +26504524,3046,,affects,,Folic Acid,,,,neoplasm,,,,, +26433324,3047,,affects,,Folic Acid,,,,psychotic disorder,,,,, +25046427,3048,,affects,,Folic Acid,,,,malaria,,,,, +24121807,3049,,affects,,Folic Acid,,,,osteoporosis,,,,, +23769753,3050,,affects,,Folic Acid,,,,anemia,,,,, +22602503,3051,,affects,,Folic Acid,,,,gingival overgrowth,,,,, +21177262,3052,,affects,,Folic Acid,,,,autism spectrum disorder,,,,, +20060781,3053,,affects,,Folic Acid,,,,Hemorrhage,,,,, +19336710,3054,,affects,,Folic Acid,,,,polycystic ovary syndrome,,,,, +19172236,3055,,affects,,Folic Acid,,,,chronic kidney disease,,,,, +19066599,3056,,affects,,Folic Acid,,,,Alzheimer disease,,,,, +15798837,3057,,affects,,Folic Acid,,,,hypertensive disorder,,,,, +15143772,3058,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, +14869410,3059,,affects,,Folic Acid,,,,epilepsy,,,,, +14664528,3060,,affects,,Folic Acid,,,,depressive disorder,,,,, +14002988,3061,,affects,,Folic Acid,,,,depressive disorder,,,,, +13092563,3062,,affects,,Folic Acid,,,,depressive disorder,,,,, +12773835,3063,,affects,,Folic Acid,,,,atherosclerosis,,,,, +11897009,3064,,affects,,Folic Acid,,,,Alzheimer disease,,,,, +10798682,3065,,affects,,Folic Acid,,,,type 2 diabetes mellitus,,,,, +10733114,3066,,affects,,Folic Acid,,,,Reduced blood folate concentration,,,,, +10375553,3067,,affects,,Folic Acid,,,,neoplasm,,,,, +10355008,3068,,affects,,Folic Acid,,,,anemia,,,,, +8962241,3069,,affects,,Folic Acid,,,,cleft palate,,,,, +8101952,3070,,affects,,Folic Acid,,,,neural tube defect,,,,, +7127212,3071,,affects,,Folic Acid,,,,neural tube defect,,,,, +19290979,3072,,produces,,Folic Acid,,,,neoplasm,,,,, +26301481,3073,,disrupts,,Folic Acid,,,,epilepsy,,,,, +22602502,3074,,disrupts,,Folic Acid,,,,gingival overgrowth,,,,, +21452213,3075,,disrupts,,Folic Acid,,,,cleft palate,,,,, +20711939,3076,,disrupts,,Folic Acid,,,,autism spectrum disorder,,,,, +20091947,3077,,disrupts,,Folic Acid,,,,atherosclerosis,,,,, +18758283,3078,,disrupts,,Folic Acid,,,,malaria,,,,, +18711179,3079,,disrupts,,Folic Acid,,,,hypertensive disorder,,,,, +16597425,3080,,disrupts,,Folic Acid,,,,neoplasm,,,,, +13887579,3081,,disrupts,,Folic Acid,,,,anemia,,,,, +13415357,3082,,disrupts,,Folic Acid,,,,cleft lip,,,,, +12569851,3083,,disrupts,,Folic Acid,,,,HIV infectious disease,,,,, +11807458,3084,,disrupts,,Folic Acid,,,,colorectal neoplasm,,,,, +10170875,3085,,disrupts,,Folic Acid,,,,depressive disorder,,,,, +8333532,3086,,disrupts,,Folic Acid,,,,neural tube defect,,,,, +8088152,3087,,disrupts,,Folic Acid,,,,Reduced blood folate concentration,,,,, +7255352,3088,,disrupts,,Folic Acid,,,,coronary artery disorder,,,,, +24827653,3089,,prevents,,Folic Acid,,,,Hemorrhage,,,,, +19249670,3090,,prevents,,Folic Acid,,,,epilepsy,,,,, +18676969,3091,,prevents,,Folic Acid,,,,neoplasm,,,,, +17577921,3092,,prevents,,Folic Acid,,,,diabetic kidney disease,,,,, +16233198,3093,,prevents,,Folic Acid,,,,iron deficiency anemia,,,,, +15458838,3094,,prevents,,Folic Acid,,,,myocardial ischemia,,,,, +15385859,3095,,prevents,,Folic Acid,,,,depressive disorder,,,,, +13602735,3096,,prevents,,Folic Acid,,,,gingival overgrowth,,,,, +12999215,3097,,prevents,,Folic Acid,,,,hypertensive disorder,,,,, +12947495,3098,,prevents,,Folic Acid,,,,cleft lip,,,,, +12911127,3099,,prevents,,Folic Acid,,,,Alzheimer disease,,,,, +11842763,3100,,prevents,,Folic Acid,,,,cervical polyp,,,,, +10283354,3101,,prevents,,Folic Acid,,,,heart disorder,,,,, +10242010,3102,,prevents,,Folic Acid,,,,cleft palate,,,,, +9547944,3103,,prevents,,Folic Acid,,,,atherosclerosis,,,,, +9000016,3104,,prevents,,Folic Acid,,,,anemia,,,,, +8746975,3105,,prevents,,Folic Acid,,,,Reduced blood folate concentration,,,,, +8675157,3106,,prevents,,Folic Acid,,,,coronary artery disorder,,,,, +8467407,3107,,prevents,,Folic Acid,,,,myocardial infarction,,,,, +7303516,3108,,prevents,,Folic Acid,,,,neural tube defect,,,,, +23795062,3109,,predisposes,,Folic Acid,,,,depressive disorder,,,,, +20875914,3110,,predisposes,,Folic Acid,,,,chronic kidney disease,,,,, +20436878,3111,,predisposes,,Folic Acid,,,,psychotic disorder,,,,, +19071958,3112,,predisposes,,Folic Acid,,,,type 1 diabetes mellitus,,,,, +18723777,3113,,predisposes,,Folic Acid,,,,systemic lupus erythematosus,,,,, +16571781,3114,,predisposes,,Folic Acid,,,,habitual spontaneous abortion,,,,, +16186991,3115,,predisposes,,Folic Acid,,,,Reduced blood folate concentration,,,,, +15780148,3116,,predisposes,,Folic Acid,,,,epilepsy,,,,, +15351663,3117,,predisposes,,Folic Acid,,,,breast neoplasm,,,,, +14681570,3118,,predisposes,,Folic Acid,,,,malaria,,,,, +13204073,3119,,predisposes,,Folic Acid,,,,autism spectrum disorder,,,,, +12966788,3120,,predisposes,,Folic Acid,,,,cleft palate,,,,, +12851634,3121,,predisposes,,Folic Acid,,,,osteoporosis,,,,, +12628867,3122,,predisposes,,Folic Acid,,,,neoplasm,,,,, +11373442,3123,,predisposes,,Folic Acid,,,,colorectal neoplasm,,,,, +11241979,3124,,predisposes,,Folic Acid,,,,hypertensive disorder,,,,, +9419598,3125,,predisposes,,Folic Acid,,,,Alzheimer disease,,,,, +9024956,3126,,predisposes,,Folic Acid,,,,non-small cell lung carcinoma,,,,, +8876702,3127,,predisposes,,Folic Acid,,,,atherosclerosis,,,,, +8590186,3128,,predisposes,,Folic Acid,,,,anemia,,,,, +8210149,3129,,predisposes,,Folic Acid,,,,myocardial ischemia,,,,, +8202566,3130,,predisposes,,Folic Acid,,,,coronary artery disorder,,,,, +7807562,3131,,predisposes,,Folic Acid,,,,myocardial infarction,,,,, +7720012,3132,,subclass of,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +26246718,3133,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +25613560,3134,,related to,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +20340997,3135,,physically interacts with,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +26417219,3136,,physically interacts with,,Phenylbutazone,,,,"1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine",,,,, +17467114,3137,,affects,,Phenylbutazone,,,,rheumatic disorder,,,,, +8146434,3138,,affects,,Phenylbutazone,,,,Oxyphenbutazone,,,,, +7720012,3139,,subclass of,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +25613560,3140,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +26246718,3141,,related to,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +20340997,3142,,physically interacts with,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +8146434,3143,,affects,,Oxyphenbutazone,,,,Phenylbutazone,,,,, +19336632,3144,,prevents,,Etofenamate,,,,Arthralgia,,,,, +11418550,3145,,subclass of,,Piroxicam,,,,5'-Hydroxypiroxicam,,,,, +27695181,3146,,affects,,Piroxicam,,,,osteoarthritis,,,,, +24435495,3147,,affects,,Piroxicam,,,,Pain,,,,, +18791248,3148,,disrupts,,Piroxicam,,,,Pain,,,,, +13746683,3149,,prevents,,Piroxicam,,,,Myalgia,,,,, +13092622,3150,,prevents,,Piroxicam,,,,Pain,,,,, +9050885,3151,,related to,,Bufexamac,,,,rheumatic disorder,,,,, +27600921,3152,,related to,,Mometasone furoate,,,,psoriasis,,,,, +26936147,3153,,related to,,Mometasone furoate,,,,skin disorder,,,,, +20328277,3154,,related to,,Mometasone furoate,,,,obstructive sleep apnea syndrome,,,,, +20031657,3155,,related to,,Mometasone furoate,,,,diffuse alopecia areata,,,,, +18451558,3156,,related to,,Mometasone furoate,,,,spinal cord injury,,,,, +15193244,3157,,related to,,Mometasone furoate,,,,severe acute respiratory syndrome,,,,, +12129006,3158,,related to,,Mometasone furoate,,,,asthma,,,,, +12122099,3159,,related to,,Mometasone furoate,,,,allergic rhinitis,,,,, +11696210,3160,,related to,,Mometasone furoate,,,,chronic obstructive pulmonary disease,,,,, +10078337,3161,,related to,,Mometasone furoate,,,,perennial allergic rhinitis,,,,, +8366912,3162,,related to,,Mometasone furoate,,,,seasonal allergic rhinitis,,,,, +15620377,3163,,affects,,Mometasone furoate,,,,asthma,,,,, +14474022,3164,,affects,,Mometasone furoate,,,,Nasal congestion,,,,, +8375063,3165,,affects,,Mometasone furoate,,,,allergic rhinitis,,,,, +17026384,3166,,prevents,,Mometasone furoate,,,,Nasal congestion,,,,, +15945486,3167,,prevents,,Mometasone furoate,,,,nasal cavity polyp,,,,, +10581126,3168,,related to,,Methimazole,,,,hyperthyroidism,,,,, +8213703,3169,,causes,,Methimazole,,,,hyperthyroidism,,,,, +10543639,3170,,affects,,Methimazole,,,,hyperthyroidism,,,,, +25010771,3171,,prevents,,Methimazole,,,,hyperthyroidism,,,,, +24946616,3172,,physically interacts with,,Safinamide,,,,Monoamine Oxidase B,,,,, +19231919,3173,,affects,,Safinamide,,,,Parkinson disease,,,,, +13464423,3174,,affects,,Safinamide,,,,Monoamine Oxidase B,,,,, +25942595,3175,,related to,,Furosemide,,,,nephrotic syndrome,,,,, +25824332,3176,,related to,,Furosemide,,,,Fibrosis,,,,, +25791999,3177,,related to,,Furosemide,,,,cirrhosis of liver,,,,, +25414865,3178,,related to,,Furosemide,,,,syndromic disease,,,,, +24461287,3179,,related to,,Furosemide,,,,essential hypertension,,,,, +22834232,3180,,related to,,Furosemide,,,,type 2 diabetes mellitus,,,,, +19148228,3181,,related to,,Furosemide,,,,hypertensive disorder,,,,, +13031496,3182,,related to,,Furosemide,,,,acute kidney failure,,,,, +8084093,3183,,related to,,Furosemide,,,,kidney failure,,,,, +27482853,3184,,causes,,Furosemide,,,,Edema,,,,, +27015887,3185,,causes,,Furosemide,,,,diabetes mellitus,,,,, +25990601,3186,,causes,,Furosemide,,,,hypertensive disorder,,,,, +25918508,3187,,causes,,Furosemide,,,,kidney disorder,,,,, +20167150,3188,,causes,,Furosemide,,,,syndromic disease,,,,, +19659078,3189,,causes,,Furosemide,,,,kidney failure,,,,, +11605290,3190,,causes,,Furosemide,,,,nephrotic syndrome,,,,, +9601857,3191,,causes,,Furosemide,,,,acute kidney failure,,,,, +8252635,3192,,causes,,Furosemide,,,,Dyspnea,,,,, +26185017,3193,,affects,,Furosemide,,,,myocardial infarction,,,,, +25909260,3194,,affects,,Furosemide,,,,nephrotic syndrome,,,,, +22504977,3195,,affects,,Furosemide,,,,cirrhosis of liver,,,,, +17729926,3196,,affects,,Furosemide,,,,Edema,,,,, +16155102,3197,,affects,,Furosemide,,,,kidney disorder,,,,, +15732141,3198,,affects,,Furosemide,,,,hypertensive disorder,,,,, +14935630,3199,,affects,,Furosemide,,,,kidney failure,,,,, +14887041,3200,,affects,,Furosemide,,,,acute kidney failure,,,,, +14148250,3201,,affects,,Furosemide,,,,kidney failure,,,,, +13740455,3202,,affects,,Furosemide,,,,Dyspnea,,,,, +12836864,3203,,affects,,Furosemide,,,,Edema,,,,, +10718312,3204,,affects,,Furosemide,,,,diabetes mellitus,,,,, +8299615,3205,,affects,,Furosemide,,,,acute kidney failure,,,,, +27482854,3206,,disrupts,,Furosemide,,,,Edema,,,,, +19844878,3207,,disrupts,,Furosemide,,,,Dyspnea,,,,, +24717003,3208,,prevents,,Furosemide,,,,pulmonary edema,,,,, +22953098,3209,,prevents,,Furosemide,,,,Dyspnea,,,,, +21527038,3210,,prevents,,Furosemide,,,,schizophrenia,,,,, +20769925,3211,,prevents,,Furosemide,,,,bronchopulmonary dysplasia,,,,, +12415888,3212,,prevents,,Furosemide,,,,kidney disorder,,,,, +11075685,3213,,prevents,,Furosemide,,,,hypertensive disorder,,,,, +9165205,3214,,prevents,,Furosemide,,,,Edema,,,,, +8733555,3215,,prevents,,Furosemide,,,,syndromic disease,,,,, +7901682,3216,,prevents,,Furosemide,,,,kidney failure,,,,, +24388792,3217,,predisposes,,Furosemide,,,,acute kidney failure,,,,, +23800241,3218,,predisposes,,Furosemide,,,,myocardial infarction,,,,, +21525697,3219,,predisposes,,Furosemide,,,,atherosclerosis,,,,, +16660855,3220,,predisposes,,Furosemide,,,,kidney disorder,,,,, +19565633,3221,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, +14176438,3222,,physically interacts with,,Nabumetone,,,,Cyclooxygenase 2,,,,, +15189827,3223,,affects,,Nabumetone,,,,osteoarthritis,,,,, +9219116,3224,,affects,,Nabumetone,,,,Cyclooxygenase 2,,,,, +11784119,3225,,related to,,Selegiline,,,,Parkinson disease,,,,, +7091710,3226,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, +7091710,3227,,related to,,Selegiline,,,,Monoamine Oxidase B,,,,, +26670675,3228,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, +26670675,3229,,coexists with,,Selegiline,,,,Monoamine Oxidase B,,,,, +13016594,3230,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, +26762387,3231,,physically interacts with,,Selegiline,,,,Monoamine Oxidase B,,,,, +27251718,3232,,causes,,Selegiline,,,,depressive disorder,,,,, +18216942,3233,,causes,,Selegiline,,,,Parkinson disease,,,,, +8842901,3234,,affects,,Selegiline,,,,Parkinson disease,,,,, +7091708,3235,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, +8615177,3236,,affects,,Selegiline,,,,Monoamine Oxidase B,,,,, +11022843,3237,,disrupts,,Selegiline,,,,Parkinson disease,,,,, +8202759,3238,,prevents,,Selegiline,,,,depressive disorder,,,,, +7205408,3239,,prevents,,Selegiline,,,,Parkinson disease,,,,, +21543223,3240,,causes,,Bumetanide,,,,pervasive developmental disorder,,,,, +22325231,3241,,affects,,Bumetanide,,,,pervasive developmental disorder,,,,, +20190253,3242,,affects,,Bumetanide,,,,autism spectrum disorder,,,,, +16914848,3243,,prevents,,Bumetanide,,,,autism spectrum disorder,,,,, +11943751,3244,,related to,,D-Glucosamine,,,,breast neoplasm,,,,, +7809202,3245,,related to,,D-Glucosamine,,,,osteoarthritis,,,,, +27619077,3246,,causes,,D-Glucosamine,,,,obesity disorder,,,,, +18633463,3247,,causes,,D-Glucosamine,,,,osteoarthritis,,,,, +9909825,3248,,affects,,D-Glucosamine,,,,osteoarthritis,,,,, +8968754,3249,,affects,,D-Glucosamine,,,,obesity disorder,,,,, +13460623,3250,,disrupts,,D-Glucosamine,,,,osteoarthritis,,,,, +11817662,3251,,prevents,,D-Glucosamine,,,,osteoarthritis,,,,, +25749858,3252,,causes,,Torsemide,,,,hypertensive disorder,,,,, +26478746,3253,,affects,,Torsemide,,,,hypertensive disorder,,,,, +13754465,3254,,affects,,Torsemide,,,,hypertensive disorder,,,,, +24478260,3255,,related to,,Leuprorelin,,,,infertility disorder,,,,, +22375547,3256,,related to,,Leuprorelin,,,,neoplasm,,,,, +17696905,3257,,related to,,Leuprorelin,,,,leiomyoma,,,,, +16368292,3258,,related to,,Leuprorelin,,,,prostate cancer,,,,, +15413679,3259,,related to,,Leuprorelin,,,,endometriosis,,,,, +9878755,3260,,causes,,Leuprorelin,,,,hypogonadism,,,,, +7418968,3261,,causes,,Leuprorelin,,,,neoplasm,,,,, +27571709,3262,,affects,,Leuprorelin,,,,prostate cancer,,,,, +27571708,3263,,affects,,Leuprorelin,,,,endometriosis,,,,, +26547561,3264,,affects,,Leuprorelin,,,,endometriosis,,,,, +26152029,3265,,affects,,Leuprorelin,,,,prostate cancer,,,,, +27542556,3266,,prevents,,Leuprorelin,,,,neoplasm,,,,, +12402472,3267,,prevents,,Leuprorelin,,,,Pain,,,,, +7814590,3268,,subclass of,,Sodium Bicarbonate,,,,Electrolytes,,,,, +26447678,3269,,related to,,Sodium Bicarbonate,,,,cystic fibrosis,,,,, +26270339,3270,,related to,,Sodium Bicarbonate,,,,kidney failure,,,,, +20718850,3271,,related to,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +15047625,3272,,related to,,Sodium Bicarbonate,,,,Pain,,,,, +14688492,3273,,related to,,Sodium Bicarbonate,,,,chronic renal failure syndrome,,,,, +13166244,3274,,related to,,Sodium Bicarbonate,,,,kidney disorder,,,,, +12100581,3275,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, +13772853,3276,,physically interacts with,,Sodium Bicarbonate,,,,Electrolytes,,,,, +27495118,3277,,causes,,Sodium Bicarbonate,,,,kidney failure,,,,, +18327883,3278,,causes,,Sodium Bicarbonate,,,,kidney disorder,,,,, +14549296,3279,,causes,,Sodium Bicarbonate,,,,injury,,,,, +8914995,3280,,causes,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +25712033,3281,,affects,,Sodium Bicarbonate,,,,Abnormality of acid-base homeostasis,,,,, +18411502,3282,,affects,,Sodium Bicarbonate,,,,injury,,,,, +17654743,3283,,affects,,Sodium Bicarbonate,,,,kidney disorder,,,,, +12960490,3284,,affects,,Sodium Bicarbonate,,,,Pain,,,,, +8914994,3285,,affects,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +14651482,3286,,disrupts,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +21103228,3287,,prevents,,Sodium Bicarbonate,,,,acidosis disorder,,,,, +13938650,3288,,prevents,,Sodium Bicarbonate,,,,injury,,,,, +11746267,3289,,prevents,,Sodium Bicarbonate,,,,kidney failure,,,,, +11205688,3290,,prevents,,Sodium Bicarbonate,,,,acute kidney failure,,,,, +11205686,3291,,prevents,,Sodium Bicarbonate,,,,kidney disorder,,,,, +14663272,3292,,predisposes,,Sodium Bicarbonate,,,,kidney disorder,,,,, +14542214,3293,,predisposes,,Sodium Bicarbonate,,,,injury,,,,, +17530350,3294,,affects,,Olmesartan medoxomil,,,,diabetic kidney disease,,,,, +12894557,3295,,affects,,Olmesartan medoxomil,,,,atherosclerosis,,,,, +12254737,3296,,affects,,Olmesartan medoxomil,,,,diabetes mellitus,,,,, +15583038,3297,,disrupts,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, +12254736,3298,,disrupts,,Olmesartan medoxomil,,,,proteinuria,,,,, +12254735,3299,,prevents,,Olmesartan medoxomil,,,,hypertensive disorder,,,,, +9359700,3300,,prevents,,Olmesartan medoxomil,,,,atherosclerosis,,,,, +8752749,3301,,related to,,Candesartan,,,,essential hypertension,,,,, +20752265,3302,,causes,,Candesartan,,,,Cognitive impairment,,,,, +14838058,3303,,causes,,Candesartan,,,,hypertensive disorder,,,,, +20512666,3304,,affects,,Candesartan,,,,Cognitive impairment,,,,, +20051167,3305,,affects,,Candesartan,,,,hypertensive disorder,,,,, +19501045,3306,,affects,,Candesartan,,,,Cognitive impairment,,,,, +14118850,3307,,affects,,Candesartan,,,,Left ventricular hypertrophy,,,,, +9919312,3308,,affects,,Candesartan,,,,hypertensive disorder,,,,, +14542524,3309,,disrupts,,Candesartan,,,,Left ventricular hypertrophy,,,,, +9479295,3310,,disrupts,,Candesartan,,,,hypertensive disorder,,,,, +24756017,3311,,prevents,,Candesartan,,,,Cognitive impairment,,,,, +15502429,3312,,prevents,,Candesartan,,,,cardiovascular disorder,,,,, +12994289,3313,,prevents,,Candesartan,,,,Left ventricular hypertrophy,,,,, +12444324,3314,,prevents,,Candesartan,,,,atrial fibrillation,,,,, +12421723,3315,,prevents,,Candesartan,,,,migraine disorder,,,,, +8787605,3316,,prevents,,Candesartan,,,,hypertensive disorder,,,,, +9420113,3317,,related to,,Telmisartan,,,,diabetes mellitus,,,,, +9420112,3318,,related to,,Telmisartan,,,,hypertensive disorder,,,,, +16669618,3319,,causes,,Telmisartan,,,,cardiovascular disorder,,,,, +16637024,3320,,causes,,Telmisartan,,,,hypertensive disorder,,,,, +16559226,3321,,causes,,Telmisartan,,,,myocardial infarction,,,,, +14418892,3322,,causes,,Telmisartan,,,,Albuminuria,,,,, +13301662,3323,,causes,,Telmisartan,,,,diabetes mellitus,,,,, +20835589,3324,,affects,,Telmisartan,,,,diabetic kidney disease,,,,, +17882285,3325,,affects,,Telmisartan,,,,Albuminuria,,,,, +16266744,3326,,affects,,Telmisartan,,,,Albuminuria,,,,, +15802746,3327,,affects,,Telmisartan,,,,diabetes mellitus,,,,, +13992848,3328,,affects,,Telmisartan,,,,diabetes mellitus,,,,, +13861721,3329,,affects,,Telmisartan,,,,type 2 diabetes mellitus,,,,, +13824093,3330,,affects,,Telmisartan,,,,Albuminuria,,,,, +13501012,3331,,affects,,Telmisartan,,,,essential hypertension,,,,, +13178302,3332,,affects,,Telmisartan,,,,hypertensive disorder,,,,, +25051574,3333,,disrupts,,Telmisartan,,,,Alzheimer disease,,,,, +14418891,3334,,disrupts,,Telmisartan,,,,Albuminuria,,,,, +13325686,3335,,disrupts,,Telmisartan,,,,hypertensive disorder,,,,, +21182197,3336,,prevents,,Telmisartan,,,,Alzheimer disease,,,,, +17513403,3337,,prevents,,Telmisartan,,,,myocardial infarction,,,,, +17170882,3338,,prevents,,Telmisartan,,,,type 2 diabetes mellitus,,,,, +13010398,3339,,prevents,,Telmisartan,,,,stroke disorder,,,,, +12278433,3340,,prevents,,Telmisartan,,,,diabetic kidney disease,,,,, +11585228,3341,,prevents,,Telmisartan,,,,diabetes mellitus,,,,, +11585227,3342,,prevents,,Telmisartan,,,,cardiovascular disorder,,,,, +11473935,3343,,prevents,,Telmisartan,,,,hypertensive disorder,,,,, +17028323,3344,,predisposes,,Telmisartan,,,,stroke disorder,,,,, +17028322,3345,,predisposes,,Telmisartan,,,,myocardial infarction,,,,, +21651336,3346,,causes,,Irbesartan,,,,hypertensive disorder,,,,, +19454247,3347,,affects,,Irbesartan,,,,Sepsis,,,,, +13143483,3348,,affects,,Irbesartan,,,,type 2 diabetes mellitus,,,,, +9015828,3349,,affects,,Irbesartan,,,,chronic kidney disease,,,,, +9015827,3350,,affects,,Irbesartan,,,,diabetic kidney disease,,,,, +7812861,3351,,affects,,Irbesartan,,,,acute kidney failure,,,,, +19016605,3352,,disrupts,,Irbesartan,,,,atrial fibrillation,,,,, +11936096,3353,,disrupts,,Irbesartan,,,,hypertensive disorder,,,,, +9297339,3354,,disrupts,,Irbesartan,,,,diabetic kidney disease,,,,, +11467158,3355,,prevents,,Irbesartan,,,,chronic kidney disease,,,,, +9856662,3356,,prevents,,Irbesartan,,,,diabetic kidney disease,,,,, +8753962,3357,,prevents,,Irbesartan,,,,hypertensive disorder,,,,, +15497727,3358,,predisposes,,Irbesartan,,,,cardiovascular disorder,,,,, +12041301,3359,,predisposes,,Irbesartan,,,,IgA glomerulonephritis,,,,, +9459261,3360,,related to,,Eprosartan,,,,essential hypertension,,,,, +8111433,3361,,related to,,Valsartan,,,,essential hypertension,,,,, +18505936,3362,,causes,,Valsartan,,,,myocardial infarction,,,,, +13301661,3363,,causes,,Valsartan,,,,diabetes mellitus,,,,, +18533693,3364,,affects,,Valsartan,,,,hypertensive disorder,,,,, +18130226,3365,,affects,,Valsartan,,,,stroke disorder,,,,, +16609149,3366,,affects,,Valsartan,,,,kidney disorder,,,,, +9837968,3367,,affects,,Valsartan,,,,Abnormal left ventricular function,,,,, +15479686,3368,,disrupts,,Valsartan,,,,type 2 diabetes mellitus,,,,, +11438135,3369,,disrupts,,Valsartan,,,,atherosclerosis,,,,, +20671333,3370,,prevents,,Valsartan,,,,Abnormal left ventricular function,,,,, +15012324,3371,,prevents,,Valsartan,,,,type 2 diabetes mellitus,,,,, +13899819,3372,,prevents,,Valsartan,,,,stroke disorder,,,,, +12374506,3373,,prevents,,Valsartan,,,,diabetes mellitus,,,,, +12038680,3374,,prevents,,Valsartan,,,,myocardial infarction,,,,, +11801448,3375,,prevents,,Valsartan,,,,atrial fibrillation,,,,, +8617185,3376,,prevents,,Valsartan,,,,coronary artery disorder,,,,, +7691192,3377,,prevents,,Valsartan,,,,hypertensive disorder,,,,, +7604460,3378,,prevents,,Valsartan,,,,atherosclerosis,,,,, +21524148,3379,,predisposes,,Valsartan,,,,myocardial infarction,,,,, +11133518,3380,,predisposes,,Valsartan,,,,cardiovascular disorder,,,,, +13065808,3381,,related to,,Losartan,,,,non-alcoholic fatty liver disease,,,,, +12094342,3382,,related to,,Losartan,,,,proteinuria,,,,, +11472713,3383,,related to,,Losartan,,,,kidney disorder,,,,, +10013644,3384,,related to,,Losartan,,,,hypertensive disorder,,,,, +8975375,3385,,related to,,Losartan,,,,IgA glomerulonephritis,,,,, +16215194,3386,,causes,,Losartan,,,,injury,,,,, +15690681,3387,,causes,,Losartan,,,,kidney disorder,,,,, +9749061,3388,,causes,,Losartan,,,,hypertensive disorder,,,,, +7310301,3389,,causes,,Losartan,,,,proteinuria,,,,, +7204638,3390,,causes,,Losartan,,,,Left ventricular hypertrophy,,,,, +26608778,3391,,affects,,Losartan,,,,essential hypertension,,,,, +24425437,3392,,affects,,Losartan,,,,cystic fibrosis,,,,, +21888728,3393,,affects,,Losartan,,,,proteinuria,,,,, +20488125,3394,,affects,,Losartan,,,,hypertensive disorder,,,,, +19990804,3395,,affects,,Losartan,,,,aortic valve insufficiency,,,,, +18707849,3396,,affects,,Losartan,,,,hypertrophic cardiomyopathy,,,,, +16976701,3397,,affects,,Losartan,,,,IgA glomerulonephritis,,,,, +13986638,3398,,affects,,Losartan,,,,adult acute respiratory distress syndrome,,,,, +13539739,3399,,affects,,Losartan,,,,proteinuria,,,,, +13498248,3400,,affects,,Losartan,,,,Inflammation,,,,, +12531070,3401,,affects,,Losartan,,,,Left ventricular hypertrophy,,,,, +10809955,3402,,affects,,Losartan,,,,hypertensive disorder,,,,, +9615315,3403,,affects,,Losartan,,,,diabetic kidney disease,,,,, +9459571,3404,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, +9229634,3405,,affects,,Losartan,,,,kidney disorder,,,,, +8678480,3406,,affects,,Losartan,,,,injury,,,,, +8551167,3407,,affects,,Losartan,,,,type 2 diabetes mellitus,,,,, +18715311,3408,,disrupts,,Losartan,,,,breast neoplasm,,,,, +14458903,3409,,disrupts,,Losartan,,,,pancreatic neoplasm,,,,, +13976332,3410,,disrupts,,Losartan,,,,diabetic kidney disease,,,,, +12949848,3411,,disrupts,,Losartan,,,,Inflammation,,,,, +9870082,3412,,disrupts,,Losartan,,,,hypertensive disorder,,,,, +9655766,3413,,disrupts,,Losartan,,,,type 2 diabetes mellitus,,,,, +8325352,3414,,disrupts,,Losartan,,,,Left ventricular hypertrophy,,,,, +7975855,3415,,disrupts,,Losartan,,,,injury,,,,, +7310299,3416,,disrupts,,Losartan,,,,proteinuria,,,,, +21356716,3417,,prevents,,Losartan,,,,post-traumatic stress disorder,,,,, +14540327,3418,,prevents,,Losartan,,,,kidney disorder,,,,, +12407992,3419,,prevents,,Losartan,,,,Inflammation,,,,, +10030687,3420,,prevents,,Losartan,,,,cardiovascular disorder,,,,, +9856661,3421,,prevents,,Losartan,,,,diabetic kidney disease,,,,, +9773800,3422,,prevents,,Losartan,,,,Left ventricular hypertrophy,,,,, +9766007,3423,,prevents,,Losartan,,,,adult acute respiratory distress syndrome,,,,, +9420091,3424,,prevents,,Losartan,,,,Stenosis,,,,, +9077908,3425,,prevents,,Losartan,,,,proteinuria,,,,, +8542944,3426,,prevents,,Losartan,,,,injury,,,,, +7768196,3427,,prevents,,Losartan,,,,hypertensive disorder,,,,, +14272023,3428,,predisposes,,Losartan,,,,kidney disorder,,,,, +12616336,3429,,predisposes,,Losartan,,,,cardiovascular disorder,,,,, +9964252,3430,,predisposes,,Losartan,,,,Left ventricular hypertrophy,,,,, +20586471,3431,,related to,,Dronabinol,,,,multiple sclerosis,,,,, +25459397,3432,,causes,,Dronabinol,,,,cannabis dependence,,,,, +22027243,3433,,causes,,Dronabinol,,,,Nausea,,,,, +17252204,3434,,causes,,Dronabinol,,,,schizophrenia,,,,, +12205989,3435,,causes,,Dronabinol,,,,Cognitive impairment,,,,, +27448088,3436,,affects,,Dronabinol,,,,Anorexia,,,,, +25890458,3437,,affects,,Dronabinol,,,,Nausea,,,,, +21879717,3438,,affects,,Dronabinol,,,,anorexia nervosa,,,,, +20855895,3439,,affects,,Dronabinol,,,,neoplasm,,,,, +19991701,3440,,affects,,Dronabinol,,,,obstructive sleep apnea syndrome,,,,, +19474044,3441,,affects,,Dronabinol,,,,multiple sclerosis,,,,, +16547908,3442,,affects,,Dronabinol,,,,schizophrenia,,,,, +14443952,3443,,affects,,Dronabinol,,,,opiate dependence,,,,, +13958866,3444,,affects,,Dronabinol,,,,Cognitive impairment,,,,, +13933776,3445,,affects,,Dronabinol,,,,schizophrenia,,,,, +11304843,3446,,affects,,Dronabinol,,,,neuralgia,,,,, +11058493,3447,,affects,,Dronabinol,,,,Pain,,,,, +24013541,3448,,disrupts,,Dronabinol,,,,Pain,,,,, +17477155,3449,,disrupts,,Dronabinol,,,,HIV infectious disease,,,,, +11615857,3450,,disrupts,,Dronabinol,,,,Nausea,,,,, +25196408,3451,,prevents,,Dronabinol,,,,dementia,,,,, +25026370,3452,,prevents,,Dronabinol,,,,neuralgia,,,,, +18579580,3453,,prevents,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, +18554637,3454,,prevents,,Dronabinol,,,,Nausea,,,,, +17477149,3455,,prevents,,Dronabinol,,,,HIV infectious disease,,,,, +9671016,3456,,prevents,,Dronabinol,,,,Pain,,,,, +22976957,3457,,predisposes,,Dronabinol,,,,Cognitive impairment,,,,, +18579581,3458,,predisposes,,Dronabinol,,,,Postoperative Nausea and Vomiting,,,,, +26722658,3459,,affects,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, +26699974,3460,,affects,,Cesamet,,,,Nausea,,,,, +19460580,3461,,prevents,,Cesamet,,,,Postoperative Nausea and Vomiting,,,,, +25552574,3462,,related to,,Aprepitant,,,,glioblastoma,,,,, +18054447,3463,,related to,,Aprepitant,,,,Vomiting,,,,, +18054446,3464,,related to,,Aprepitant,,,,Nausea,,,,, +11788538,3465,,causes,,Aprepitant,,,,Vomiting,,,,, +11788537,3466,,causes,,Aprepitant,,,,Nausea,,,,, +23692862,3467,,affects,,Aprepitant,,,,Nausea,,,,, +19750085,3468,,affects,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, +17874842,3469,,affects,,Aprepitant,,,,Vomiting,,,,, +12562288,3470,,affects,,Aprepitant,,,,Nausea,,,,, +11119543,3471,,affects,,Aprepitant,,,,Vomiting,,,,, +19013645,3472,,disrupts,,Aprepitant,,,,HIV infectious disease,,,,, +16125731,3473,,disrupts,,Aprepitant,,,,Vomiting,,,,, +16125730,3474,,disrupts,,Aprepitant,,,,Nausea,,,,, +16513148,3475,,prevents,,Aprepitant,,,,Pruritus,,,,, +15868137,3476,,prevents,,Aprepitant,,,,Postoperative Nausea and Vomiting,,,,, +10160541,3477,,prevents,,Aprepitant,,,,Vomiting,,,,, +10160540,3478,,prevents,,Aprepitant,,,,Nausea,,,,, +20804596,3479,,predisposes,,Aprepitant,,,,Nausea,,,,, +22122089,3480,,affects,,Neratinib,,,,neoplasm,,,,, +21597229,3481,,related to,,Lapatinib,,,,neoplasm,,,,, +13650844,3482,,related to,,Lapatinib,,,,non-small cell lung carcinoma,,,,, +18268107,3483,,affects,,Lapatinib,,,,neoplasm,,,,, +15442238,3484,,affects,,Lapatinib,,,,breast neoplasm,,,,, +14691634,3485,,affects,,Lapatinib,,,,neoplasm,,,,, +17546445,3486,,disrupts,,Lapatinib,,,,neoplasm,,,,, +19410918,3487,,prevents,,Lapatinib,,,,breast neoplasm,,,,, +19317295,3488,,prevents,,Lapatinib,,,,neoplasm,,,,, +16643911,3489,,predisposes,,Lapatinib,,,,neoplasm,,,,, +24360220,3490,,related to,,Nifurtimox,,,,human African trypanosomiasis,,,,, +25977066,3491,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, +25977066,3492,,coexists with,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, +25822629,3493,,causes,,Nifurtimox,,,,Chagas disease,,,,, +21140520,3494,,affects,,Nifurtimox,,,,neuroblastoma,,,,, +19390598,3495,,affects,,Nifurtimox,,,,trypanosomiasis,,,,, +18236131,3496,,affects,,Nifurtimox,,,,Deoxyribonucleic acid,,,,, +21140519,3497,,disrupts,,Nifurtimox,,,,neuroblastoma,,,,, +16729888,3498,,prevents,,Nifurtimox,,,,Chagas disease,,,,, +8359719,3499,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +8359719,3500,,coexists with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +21506050,3501,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +16350865,3502,,physically interacts with,,Nitrofurazone,,,,Deoxyribonucleic acid,,,,, +26982963,3503,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, +14891197,3504,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, +13216168,3505,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, +9844335,3506,,affects,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, +11447618,3507,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Pain,,,,, +11253841,3508,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,Drooling,,,,, +8806634,3509,,prevents,,SCOPOLAMINE HYDROBROMIDE,,,,motion sickness,,,,, +26997768,3510,,affects,,Metopimazine,,,,Nausea,,,,, +12265728,3511,,prevents,,Metopimazine,,,,Nausea,,,,, +27200379,3512,,related to,,Lincomycin,,,,osteomyelitis,,,,, +9905527,3513,,causes,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +9905522,3514,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +8547552,3515,,affects,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +11060423,3516,,prevents,,Sulindac,,,,classic familial adenomatous polyposis,,,,, +20876966,3517,,related to,,Ketorolac,,,,migraine disorder,,,,, +27688883,3518,,causes,,Ketorolac,,,,Inflammation,,,,, +21368479,3519,,causes,,Ketorolac,,,,pancreatitis,,,,, +19597016,3520,,causes,,Ketorolac,,,,Miosis,,,,, +12090892,3521,,causes,,Ketorolac,,,,Pain,,,,, +20018980,3522,,affects,,Ketorolac,,,,breast neoplasm,,,,, +19245410,3523,,affects,,Ketorolac,,,,Miosis,,,,, +9719257,3524,,affects,,Ketorolac,,,,Pain,,,,, +24071071,3525,,disrupts,,Ketorolac,,,,Headache,,,,, +24029444,3526,,disrupts,,Ketorolac,,,,Inflammation,,,,, +11549492,3527,,disrupts,,Ketorolac,,,,Pain,,,,, +11362008,3528,,disrupts,,Ketorolac,,,,Back pain,,,,, +24306825,3529,,prevents,,Ketorolac,,,,Renal Colic,,,,, +23612322,3530,,prevents,,Ketorolac,,,,Chronic pain,,,,, +20717559,3531,,prevents,,Ketorolac,,,,injury,,,,, +11362007,3532,,prevents,,Ketorolac,,,,Back pain,,,,, +11361661,3533,,prevents,,Ketorolac,,,,Inflammation,,,,, +11043378,3534,,prevents,,Ketorolac,,,,Headache,,,,, +7985904,3535,,prevents,,Ketorolac,,,,Pain,,,,, +20028754,3536,,predisposes,,Ketorolac,,,,injury,,,,, +25929768,3537,,related to,,Sulfadiazine,,,,congenital toxoplasmosis,,,,, +16546748,3538,,related to,,Sulfadiazine,,,,chorioretinitis,,,,, +27660461,3539,,causes,,Sulfamethoxazole,,,,pneumonia,,,,, +24328685,3540,,causes,,Sulfamethoxazole,,,,kidney disorder,,,,, +14835537,3541,,affects,,Sulfamethoxazole,,,,cystic fibrosis,,,,, +12226918,3542,,affects,,Sulfamethoxazole,,,,ocular toxoplasmosis,,,,, +26634163,3543,,prevents,,Sulfamethoxazole,,,,bacterial infectious disease,,,,, +23781290,3544,,prevents,,Sulfamethoxazole,,,,Infection,,,,, +22185408,3545,,prevents,,Sulfamethoxazole,,,,pneumocystosis,,,,, +21716989,3546,,affects,,Glycyrrhizic acid,,,,osteoarthritis,,,,, +21716987,3547,,disrupts,,Glycyrrhizic acid,,,,osteoarthritis,,,,, +13246285,3548,,related to,,Ciclesonide,,,,perennial allergic rhinitis,,,,, +13246284,3549,,related to,,Ciclesonide,,,,seasonal allergic rhinitis,,,,, +10789097,3550,,related to,,Ciclesonide,,,,asthma,,,,, +13334776,3551,,causes,,Ciclesonide,,,,asthma,,,,, +13603690,3552,,affects,,Ciclesonide,,,,asthma,,,,, +26135729,3553,,related to,,Flunisolide,,,,perennial allergic rhinitis,,,,, +16438918,3554,,related to,,Flunisolide,,,,rhinitis,,,,, +7778368,3555,,related to,,Flunisolide,,,,asthma,,,,, +12189287,3556,,prevents,,Flunisolide,,,,Nasal congestion,,,,, +27725383,3557,,related to,,Etoposide,,,,hepatoblastoma,,,,, +27360363,3558,,related to,,Etoposide,,,,ependymoma,,,,, +27062931,3559,,related to,,Etoposide,,,,supratentorial primitive neuroectodermal tumor,,,,, +26965210,3560,,related to,,Etoposide,,,,kidney Wilms tumor,,,,, +26632944,3561,,related to,,Etoposide,,,,HIV infectious disease,,,,, +22727077,3562,,related to,,Etoposide,,,,mature T-cell and NK-cell non-Hodgkin lymphoma,,,,, +21142004,3563,,related to,,Etoposide,,,,AIDS,,,,, +20988037,3564,,related to,,Etoposide,,,,retinoblastoma,,,,, +20394132,3565,,related to,,Etoposide,,,,B-cell neoplasm,,,,, +19900770,3566,,related to,,Etoposide,,,,myelodysplastic syndrome,,,,, +18768176,3567,,related to,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, +17380085,3568,,related to,,Etoposide,,,,Kaposi's sarcoma,,,,, +17284305,3569,,related to,,Etoposide,,,,bone osteosarcoma,,,,, +17191209,3570,,related to,,Etoposide,,,,hepatocellular carcinoma,,,,, +17136035,3571,,related to,,Etoposide,,,,diffuse large B-cell lymphoma,,,,, +16406847,3572,,related to,,Etoposide,,,,neuroendocrine carcinoma,,,,, +16067960,3573,,related to,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, +15501025,3574,,related to,,Etoposide,,,,brain cancer,,,,, +15141728,3575,,related to,,Etoposide,,,,testicular cancer,,,,, +15031494,3576,,related to,,Etoposide,,,,lymphoid leukemia,,,,, +14511230,3577,,related to,,Etoposide,,,,glioblastoma,,,,, +14453465,3578,,related to,,Etoposide,,,,T-cell non-Hodgkin lymphoma,,,,, +13764189,3579,,related to,,Etoposide,,,,"chronic myelogenous leukemia, BCR-ABL1 positive",,,,, +12298091,3580,,related to,,Etoposide,,,,breast neoplasm,,,,, +11028194,3581,,related to,,Etoposide,,,,acute lymphoblastic leukemia,,,,, +10672040,3582,,related to,,Etoposide,,,,Ewing sarcoma,,,,, +10503115,3583,,related to,,Etoposide,,,,kidney cancer,,,,, +10441577,3584,,related to,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, +10410657,3585,,related to,,Etoposide,,,,neutropenia,,,,, +10182075,3586,,related to,,Etoposide,,,,non-Hodgkin lymphoma,,,,, +10161953,3587,,related to,,Etoposide,,,,squamous cell carcinoma,,,,, +9231982,3588,,related to,,Etoposide,,,,carcinoma,,,,, +9157972,3589,,related to,,Etoposide,,,,thymoma,,,,, +9138703,3590,,related to,,Etoposide,,,,ovarian cancer,,,,, +9115115,3591,,related to,,Etoposide,,,,sarcoma,,,,, +9024985,3592,,related to,,Etoposide,,,,leukemia,,,,, +9008448,3593,,related to,,Etoposide,,,,Hodgkins lymphoma,,,,, +9006645,3594,,related to,,Etoposide,,,,neuroblastoma,,,,, +8074798,3595,,related to,,Etoposide,,,,medulloblastoma,,,,, +8048523,3596,,related to,,Etoposide,,,,lymphoma,,,,, +7998504,3597,,related to,,Etoposide,,,,plasma cell myeloma,,,,, +7989979,3598,,related to,,Etoposide,,,,neoplasm,,,,, +7896801,3599,,related to,,Etoposide,,,,adult T-cell leukemia/lymphoma,,,,, +7845509,3600,,related to,,Etoposide,,,,glioma,,,,, +7810052,3601,,related to,,Etoposide,,,,castration-resistant prostate carcinoma,,,,, +7711547,3602,,related to,,Etoposide,,,,acute myeloid leukemia,,,,, +7319060,3603,,related to,,Etoposide,,,,small cell lung carcinoma,,,,, +7200681,3604,,related to,,Etoposide,,,,non-small cell lung carcinoma,,,,, +23328204,3605,,causes,,Etoposide,,,,small cell lung carcinoma,,,,, +12215704,3606,,causes,,Etoposide,,,,neoplasm,,,,, +8706370,3607,,causes,,Etoposide,,,,neutropenia,,,,, +7869845,3608,,causes,,Etoposide,,,,leukemia,,,,, +7642766,3609,,causes,,Etoposide,,,,acute myeloid leukemia,,,,, +27374335,3610,,affects,,Etoposide,,,,retinoblastoma,,,,, +26960810,3611,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, +25269562,3612,,affects,,Etoposide,,,,hemophagocytic syndrome,,,,, +23238600,3613,,affects,,Etoposide,,,,choriocarcinoma,,,,, +18166706,3614,,affects,,Etoposide,,,,neuroblastoma,,,,, +17967080,3615,,affects,,Etoposide,,,,leukemia,,,,, +17160632,3616,,affects,,Etoposide,,,,carcinoma,,,,, +16724406,3617,,affects,,Etoposide,,,,neoplasm,,,,, +16425822,3618,,affects,,Etoposide,,,,leukemia,,,,, +15965763,3619,,affects,,Etoposide,,,,testicular cancer,,,,, +12798395,3620,,affects,,Etoposide,,,,hematopoietic and lymphoid system neoplasm,,,,, +11699750,3621,,affects,,Etoposide,,,,small cell lung carcinoma,,,,, +11396769,3622,,affects,,Etoposide,,,,chronic myelomonocytic leukemia,,,,, +9913818,3623,,affects,,Etoposide,,,,acute erythroid leukemia,,,,, +9397866,3624,,affects,,Etoposide,,,,fallopian tube neoplasm,,,,, +9293530,3625,,affects,,Etoposide,,,,carcinoid tumor,,,,, +8200378,3626,,affects,,Etoposide,,,,neoplasm,,,,, +8003315,3627,,affects,,Etoposide,,,,cutaneous neuroendocrine carcinoma,,,,, +7908520,3628,,affects,,Etoposide,,,,B-cell neoplasm,,,,, +24115005,3629,,disrupts,,Etoposide,,,,small cell lung carcinoma,,,,, +17149618,3630,,disrupts,,Etoposide,,,,hemophagocytic syndrome,,,,, +16511954,3631,,disrupts,,Etoposide,,,,glioblastoma,,,,, +16039903,3632,,disrupts,,Etoposide,,,,neoplasm,,,,, +14383828,3633,,disrupts,,Etoposide,,,,bone osteosarcoma,,,,, +9134229,3634,,prevents,,Etoposide,,,,neoplasm,,,,, +22634859,3635,,predisposes,,Etoposide,,,,neoplasm,,,,, +18673787,3636,,predisposes,,Etoposide,,,,brain cancer,,,,, +16345738,3637,,predisposes,,Etoposide,,,,myelodysplastic syndrome,,,,, +16345737,3638,,predisposes,,Etoposide,,,,acute myeloid leukemia,,,,, +10333072,3639,,predisposes,,Etoposide,,,,leukemia,,,,, +16677028,3640,,related to,,Teniposide,,,,neoplasm,,,,, +10688707,3641,,related to,,Teniposide,,,,lymphoma,,,,, +10688706,3642,,related to,,Teniposide,,,,leukemia,,,,, +27095076,3643,,affects,,Teniposide,,,,leukemia,,,,, +26849066,3644,,predisposes,,Teniposide,,,,leukemia,,,,, +18768362,3645,,related to,,Urofollitropin,,,,hypogonadism,,,,, +18095820,3646,,related to,,Urofollitropin,,,,primary ovarian failure,,,,, +9960851,3647,,related to,,Urofollitropin,,,,anovulation,,,,, +9716197,3648,,related to,,Urofollitropin,,,,female infertility,,,,, +8496709,3649,,related to,,Urofollitropin,,,,infertility disorder,,,,, +8454088,3650,,related to,,Urofollitropin,,,,male infertility,,,,, +8378642,3651,,related to,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +8205307,3652,,related to,,Urofollitropin,,,,azoospermia,,,,, +14878529,3653,,related to,,Urofollitropin,,,,female infertility,,,,, +9422493,3654,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +9422493,3655,,related to,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +10444908,3656,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +10444908,3657,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7103614,3658,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7103614,3659,,coexists with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7302412,3660,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +7606444,3661,,physically interacts with,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +21372974,3662,,causes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +16723493,3663,,causes,,Urofollitropin,,,,hypogonadism,,,,, +16322495,3664,,causes,,Urofollitropin,,,,azoospermia,,,,, +9453052,3665,,causes,,Urofollitropin,,,,primary ovarian failure,,,,, +8923757,3666,,causes,,Urofollitropin,,,,Pregnancy,,,,, +8815215,3667,,causes,,Urofollitropin,,,,anovulation,,,,, +8590972,3668,,causes,,Urofollitropin,,,,male infertility,,,,, +8270576,3669,,causes,,Urofollitropin,,,,infertility disorder,,,,, +19357829,3670,,affects,,Urofollitropin,,,,gonadal disorder,,,,, +15865492,3671,,affects,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +14984090,3672,,affects,,Urofollitropin,,,,male infertility,,,,, +13249247,3673,,affects,,Urofollitropin,,,,Pregnancy,,,,, +10980447,3674,,affects,,Urofollitropin,,,,Pregnancy,,,,, +8590971,3675,,affects,,Urofollitropin,,,,male infertility,,,,, +7302415,3676,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +9844029,3677,,affects,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +27587327,3678,,produces,,Urofollitropin,,,,primary ovarian failure,,,,, +20465917,3679,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +20465917,3680,,produces,,Urofollitropin,,,,Follicle Stimulating Hormone Receptor,,,,, +8502213,3681,,produces,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +20569186,3682,,disrupts,,Urofollitropin,,,,Pregnancy,,,,, +11195885,3683,,prevents,,Urofollitropin,,,,azoospermia,,,,, +17502146,3684,,predisposes,,Urofollitropin,,,,azoospermia,,,,, +16417247,3685,,predisposes,,Urofollitropin,,,,anovulation,,,,, +16278695,3686,,predisposes,,Urofollitropin,,,,infertility disorder,,,,, +15110465,3687,,predisposes,,Urofollitropin,,,,polycystic ovary syndrome,,,,, +7379891,3688,,predisposes,,Urofollitropin,,,,primary ovarian failure,,,,, +23895216,3689,,affects,,Ivacaftor,,,,cystic fibrosis,,,,, +20354463,3690,,related to,,Nitric oxide,,,,ST-elevation myocardial infarction,,,,, +17273075,3691,,related to,,Nitric oxide,,,,bronchiolitis,,,,, +15880296,3692,,related to,,Nitric oxide,,,,Diabetic Foot,,,,, +14910010,3693,,related to,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, +14573099,3694,,related to,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, +11752178,3695,,related to,,Nitric oxide,,,,cutaneous leishmaniasis,,,,, +9816415,3696,,related to,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, +9774015,3697,,related to,,Nitric oxide,,,,respiratory system disorder,,,,, +8707490,3698,,related to,,Nitric oxide,,,,myocardial infarction,,,,, +8593326,3699,,related to,,Nitric oxide,,,,neuralgia,,,,, +8476870,3700,,related to,,Nitric oxide,,,,lung disorder,,,,, +8350800,3701,,related to,,Nitric oxide,,,,opiate dependence,,,,, +8343542,3702,,related to,,Nitric oxide,,,,Varicose Ulcer,,,,, +8057943,3703,,related to,,Nitric oxide,,,,malaria,,,,, +8040944,3704,,related to,,Nitric oxide,,,,sickle cell anemia,,,,, +7963930,3705,,related to,,Nitric oxide,,,,cystic fibrosis,,,,, +7923041,3706,,related to,,Nitric oxide,,,,brain injury,,,,, +7788094,3707,,related to,,Nitric oxide,,,,myocardial ischemia,,,,, +7738003,3708,,related to,,Nitric oxide,,,,Hypoxemia,,,,, +7725812,3709,,related to,,Nitric oxide,,,,Premature birth,,,,, +7657450,3710,,related to,,Nitric oxide,,,,pulmonary embolism,,,,, +7539810,3711,,related to,,Nitric oxide,,,,stroke disorder,,,,, +7481315,3712,,related to,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +7449413,3713,,related to,,Nitric oxide,,,,respiratory failure,,,,, +7439172,3714,,related to,,Nitric oxide,,,,neoplasm,,,,, +7418030,3715,,related to,,Nitric oxide,,,,acute kidney failure,,,,, +7373096,3716,,related to,,Nitric oxide,,,,brain ischemia,,,,, +7345317,3717,,related to,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, +7242606,3718,,related to,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +7159413,3719,,related to,,Nitric oxide,,,,Sepsis,,,,, +7145311,3720,,related to,,Nitric oxide,,,,Inflammation,,,,, +7091337,3721,,related to,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +14184908,3722,,related to,,Nitric oxide,,,,Inflammation,,,,, +27698007,3723,,causes,,Nitric oxide,,,,lung disorder,,,,, +23636922,3724,,causes,,Nitric oxide,,,,Infection,,,,, +22013082,3725,,causes,,Nitric oxide,,,,sickle cell anemia,,,,, +21447838,3726,,causes,,Nitric oxide,,,,respiratory system disorder,,,,, +14028136,3727,,causes,,Nitric oxide,,,,stroke disorder,,,,, +12046903,3728,,causes,,Nitric oxide,,,,cystic fibrosis,,,,, +11887505,3729,,causes,,Nitric oxide,,,,myocardial ischemia,,,,, +11842330,3730,,causes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +11556568,3731,,causes,,Nitric oxide,,,,acute kidney failure,,,,, +11353052,3732,,causes,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +9962165,3733,,causes,,Nitric oxide,,,,malaria,,,,, +9795722,3734,,causes,,Nitric oxide,,,,neuralgia,,,,, +9068211,3735,,causes,,Nitric oxide,,,,pneumonia,,,,, +8934561,3736,,causes,,Nitric oxide,,,,brain injury,,,,, +8855613,3737,,causes,,Nitric oxide,,,,neoplasm,,,,, +8834736,3738,,causes,,Nitric oxide,,,,myocardial infarction,,,,, +8346309,3739,,causes,,Nitric oxide,,,,Premature birth,,,,, +8185371,3740,,causes,,Nitric oxide,,,,Inflammation,,,,, +8037779,3741,,causes,,Nitric oxide,,,,brain ischemia,,,,, +7409857,3742,,causes,,Nitric oxide,,,,Sepsis,,,,, +7184490,3743,,causes,,Nitric oxide,,,,Hypoxemia,,,,, +27626134,3744,,affects,,Nitric oxide,,,,cystic fibrosis,,,,, +27208311,3745,,affects,,Nitric oxide,,,,opiate dependence,,,,, +27058878,3746,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, +20413999,3747,,affects,,Nitric oxide,,,,brain injury,,,,, +19764415,3748,,affects,,Nitric oxide,,,,pneumonia,,,,, +18632674,3749,,affects,,Nitric oxide,,,,alveolar capillary dysplasia with misalignment of pulmonary veins,,,,, +17798838,3750,,affects,,Nitric oxide,,,,neuralgia,,,,, +17030125,3751,,affects,,Nitric oxide,,,,bronchiolitis,,,,, +12566083,3752,,affects,,Nitric oxide,,,,respiratory system disorder,,,,, +11778681,3753,,affects,,Nitric oxide,,,,stroke disorder,,,,, +11521495,3754,,affects,,Nitric oxide,,,,severe acute respiratory syndrome,,,,, +11353389,3755,,affects,,Nitric oxide,,,,myocardial infarction,,,,, +10403969,3756,,affects,,Nitric oxide,,,,anemia,,,,, +10222313,3757,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +10099288,3758,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, +10018002,3759,,affects,,Nitric oxide,,,,acute kidney failure,,,,, +10008267,3760,,affects,,Nitric oxide,,,,lung disorder,,,,, +9982988,3761,,affects,,Nitric oxide,,,,respiratory failure,,,,, +9910920,3762,,affects,,Nitric oxide,,,,brain ischemia,,,,, +9742582,3763,,affects,,Nitric oxide,,,,stroke disorder,,,,, +9649727,3764,,affects,,Nitric oxide,,,,neoplasm,,,,, +9102608,3765,,affects,,Nitric oxide,,,,Hypoxemia,,,,, +9095187,3766,,affects,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, +8891949,3767,,affects,,Nitric oxide,,,,Sepsis,,,,, +8832872,3768,,affects,,Nitric oxide,,,,pneumonia,,,,, +8646255,3769,,affects,,Nitric oxide,,,,myocardial ischemia,,,,, +8473168,3770,,affects,,Nitric oxide,,,,neoplasm,,,,, +8202584,3771,,affects,,Nitric oxide,,,,Sepsis,,,,, +8139693,3772,,affects,,Nitric oxide,,,,brain injury,,,,, +7935763,3773,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +7896362,3774,,affects,,Nitric oxide,,,,Inflammation,,,,, +7780898,3775,,affects,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +7712088,3776,,affects,,Nitric oxide,,,,Hypoxemia,,,,, +7542916,3777,,affects,,Nitric oxide,,,,anemia,,,,, +7169788,3778,,affects,,Nitric oxide,,,,Inflammation,,,,, +7164340,3779,,affects,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +7094195,3780,,affects,,Nitric oxide,,,,malaria,,,,, +20359925,3781,,produces,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +20299429,3782,,produces,,Nitric oxide,,,,pneumonia,,,,, +17925357,3783,,produces,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, +15219259,3784,,produces,,Nitric oxide,,,,Premature birth,,,,, +13106727,3785,,produces,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +12774415,3786,,produces,,Nitric oxide,,,,stroke disorder,,,,, +12205025,3787,,produces,,Nitric oxide,,,,Varicose Ulcer,,,,, +11786457,3788,,produces,,Nitric oxide,,,,brain ischemia,,,,, +9816411,3789,,produces,,Nitric oxide,,,,newborn respiratory distress syndrome,,,,, +8745644,3790,,produces,,Nitric oxide,,,,sickle cell anemia,,,,, +8339020,3791,,produces,,Nitric oxide,,,,acute kidney failure,,,,, +7963932,3792,,produces,,Nitric oxide,,,,cystic fibrosis,,,,, +7644756,3793,,produces,,Nitric oxide,,,,anemia,,,,, +7555266,3794,,produces,,Nitric oxide,,,,myocardial ischemia,,,,, +7511323,3795,,produces,,Nitric oxide,,,,myocardial infarction,,,,, +7507297,3796,,produces,,Nitric oxide,,,,Inflammation,,,,, +7461061,3797,,produces,,Nitric oxide,,,,Hypoxemia,,,,, +7435212,3798,,produces,,Nitric oxide,,,,neoplasm,,,,, +7390889,3799,,produces,,Nitric oxide,,,,Sepsis,,,,, +7094197,3800,,produces,,Nitric oxide,,,,malaria,,,,, +26705109,3801,,disrupts,,Nitric oxide,,,,anemia,,,,, +19923810,3802,,disrupts,,Nitric oxide,,,,stroke disorder,,,,, +14786185,3803,,disrupts,,Nitric oxide,,,,Sepsis,,,,, +12247489,3804,,disrupts,,Nitric oxide,,,,sickle cell anemia,,,,, +11088644,3805,,disrupts,,Nitric oxide,,,,cystic fibrosis,,,,, +10963665,3806,,disrupts,,Nitric oxide,,,,neoplasm,,,,, +10158293,3807,,disrupts,,Nitric oxide,,,,myocardial ischemia,,,,, +9091818,3808,,disrupts,,Nitric oxide,,,,respiratory failure,,,,, +8577648,3809,,disrupts,,Nitric oxide,,,,Inflammation,,,,, +7822328,3810,,disrupts,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +7750750,3811,,disrupts,,Nitric oxide,,,,myocardial infarction,,,,, +7555296,3812,,disrupts,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +7358959,3813,,disrupts,,Nitric oxide,,,,Hypoxemia,,,,, +26913950,3814,,prevents,,Nitric oxide,,,,adult acute respiratory distress syndrome,,,,, +25277893,3815,,prevents,,Nitric oxide,,,,neuralgia,,,,, +22898445,3816,,prevents,,Nitric oxide,,,,Infection,,,,, +21669107,3817,,prevents,,Nitric oxide,,,,neoplasm,,,,, +21628822,3818,,prevents,,Nitric oxide,,,,Hypoxemia,,,,, +21494876,3819,,prevents,,Nitric oxide,,,,Inflammation,,,,, +21062009,3820,,prevents,,Nitric oxide,,,,pulmonary embolism,,,,, +16675253,3821,,prevents,,Nitric oxide,,,,stroke disorder,,,,, +13634130,3822,,prevents,,Nitric oxide,,,,sickle cell anemia,,,,, +11584828,3823,,prevents,,Nitric oxide,,,,brain ischemia,,,,, +11450951,3824,,prevents,,Nitric oxide,,,,myocardial infarction,,,,, +10887585,3825,,prevents,,Nitric oxide,,,,pneumonia,,,,, +9990816,3826,,prevents,,Nitric oxide,,,,acute kidney failure,,,,, +9464831,3827,,prevents,,Nitric oxide,,,,myocardial ischemia,,,,, +8988568,3828,,prevents,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +8396830,3829,,prevents,,Nitric oxide,,,,cystic fibrosis,,,,, +8224065,3830,,prevents,,Nitric oxide,,,,brain injury,,,,, +8045867,3831,,prevents,,Nitric oxide,,,,lung disorder,,,,, +7996843,3832,,prevents,,Nitric oxide,,,,Sepsis,,,,, +7713281,3833,,prevents,,Nitric oxide,,,,respiratory failure,,,,, +7103253,3834,,prevents,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +27558971,3835,,exacerbates,,Nitric oxide,,,,myocardial ischemia,,,,, +26883794,3836,,exacerbates,,Nitric oxide,,,,acute kidney failure,,,,, +24530593,3837,,exacerbates,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +23305196,3838,,predisposes,,Nitric oxide,,,,cystic fibrosis,,,,, +18515843,3839,,predisposes,,Nitric oxide,,,,malaria,,,,, +17339126,3840,,predisposes,,Nitric oxide,,,,stroke disorder,,,,, +17303048,3841,,predisposes,,Nitric oxide,,,,brain ischemia,,,,, +16438716,3842,,predisposes,,Nitric oxide,,,,respiratory system disorder,,,,, +16061041,3843,,predisposes,,Nitric oxide,,,,lung disorder,,,,, +15696584,3844,,predisposes,,Nitric oxide,,,,chronic obstructive pulmonary disease,,,,, +13236015,3845,,predisposes,,Nitric oxide,,,,bronchopulmonary dysplasia,,,,, +12163328,3846,,predisposes,,Nitric oxide,,,,acute kidney failure,,,,, +12068938,3847,,predisposes,,Nitric oxide,,,,neuralgia,,,,, +11569688,3848,,predisposes,,Nitric oxide,,,,Premature birth,,,,, +9326529,3849,,predisposes,,Nitric oxide,,,,brain injury,,,,, +8098085,3850,,predisposes,,Nitric oxide,,,,neoplasm,,,,, +7895713,3851,,predisposes,,Nitric oxide,,,,pneumonia,,,,, +7863118,3852,,predisposes,,Nitric oxide,,,,Hypoxemia,,,,, +7644760,3853,,predisposes,,Nitric oxide,,,,anemia,,,,, +7373094,3854,,predisposes,,Nitric oxide,,,,ischemia reperfusion injury,,,,, +7119398,3855,,predisposes,,Nitric oxide,,,,Inflammation,,,,, +18948956,3856,,related to,,CHORIOGONADOTROPIN ALFA,,,,ovarian hyperstimulation syndrome,,,,, +10437081,3857,,related to,,CHORIONIC GONADOTROPIN,,,,hypogonadism,,,,, +10427260,3858,,related to,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, +25953720,3859,,causes,,CHORIONIC GONADOTROPIN,,,,infertility disorder,,,,, +12680602,3860,,causes,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +19382665,3861,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +10661395,3862,,affects,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +11878666,3863,,produces,,CHORIONIC GONADOTROPIN,,,,Pregnancy,,,,, +19257969,3864,,causes,,Triclosan,,,,allergic disease,,,,, +17886883,3865,,affects,,Triclosan,,,,gingivitis,,,,, +9651026,3866,,disrupts,,Triclosan,,,,gingivitis,,,,, +16053270,3867,,prevents,,Triclosan,,,,allergic disease,,,,, +20585436,3868,,affects,,Povidone iodine,,,,stomatitis,,,,, +22182083,3869,,prevents,,Povidone iodine,,,,Infection,,,,, +22061199,3870,,prevents,,Povidone iodine,,,,dental caries,,,,, +20053240,3871,,prevents,,Povidone iodine,,,,keratitis,,,,, +25268747,3872,,related to,,Vinblastine,,,,acute myeloid leukemia,,,,, +24601120,3873,,related to,,Vinblastine,,,,leukemia,,,,, +17518639,3874,,related to,,Vinblastine,,,,testicular cancer,,,,, +11295996,3875,,related to,,Vinblastine,,,,melanoma,,,,, +10629211,3876,,related to,,Vinblastine,,,,castration-resistant prostate carcinoma,,,,, +9405598,3877,,related to,,Vinblastine,,,,glioma,,,,, +8887641,3878,,related to,,Vinblastine,,,,neoplasm,,,,, +8831546,3879,,related to,,Vinblastine,,,,renal cell carcinoma,,,,, +8248825,3880,,related to,,Vinblastine,,,,lymphoma,,,,, +8201846,3881,,related to,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, +7111310,3882,,related to,,Vinblastine,,,,Hodgkins lymphoma,,,,, +22913920,3883,,causes,,Vinblastine,,,,neoplasm,,,,, +14498052,3884,,affects,,Vinblastine,,,,Langerhans cell histiocytosis,,,,, +12889760,3885,,affects,,Vinblastine,,,,renal cell carcinoma,,,,, +11723511,3886,,affects,,Vinblastine,,,,neoplasm,,,,, +19032862,3887,,disrupts,,Vinblastine,,,,neoplasm,,,,, +26195658,3888,,related to,,Desacetylvinblastine amide,,,,lymphoma,,,,, +26116904,3889,,related to,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, +25980030,3890,,related to,,Desacetylvinblastine amide,,,,small cell lung carcinoma,,,,, +26313629,3891,,affects,,Desacetylvinblastine amide,,,,neoplasm,,,,, +26201212,3892,,affects,,Desacetylvinblastine amide,,,,acute lymphoblastic leukemia,,,,, +26302410,3893,,prevents,,Desacetylvinblastine amide,,,,neoplasm,,,,, +25951740,3894,,causes,,Diazoxide,,,,hyperinsulinism,,,,, +17059197,3895,,causes,,Diazoxide,,,,hypoglycemia,,,,, +25817473,3896,,affects,,Diazoxide,,,,hypertensive disorder,,,,, +20202762,3897,,affects,,Diazoxide,,,,obesity disorder,,,,, +11393233,3898,,affects,,Diazoxide,,,,hyperinsulinism,,,,, +8184004,3899,,affects,,Diazoxide,,,,hypoglycemia,,,,, +9572369,3900,,disrupts,,Diazoxide,,,,hyperinsulinism,,,,, +26286810,3901,,prevents,,Diazoxide,,,,hypoglycemia,,,,, +22404640,3902,,prevents,,Diazoxide,,,,hypertensive disorder,,,,, +19200973,3903,,prevents,,Diazoxide,,,,obesity disorder,,,,, +16737667,3904,,predisposes,,Diazoxide,,,,hypoglycemia,,,,, +14267417,3905,,affects,,Pantoprazole,,,,gastroesophageal reflux disease,,,,, +12160514,3906,,prevents,,Pantoprazole,,,,active peptic ulcer disease,,,,, +8423273,3907,,prevents,,Pantoprazole,,,,peptic ulcer disease,,,,, +7509578,3908,,prevents,,Pantoprazole,,,,ulcer disease,,,,, +21088628,3909,,predisposes,,Pantoprazole,,,,active peptic ulcer disease,,,,, +20047688,3910,,causes,,Lansoprazole,,,,gastric ulcer,,,,, +26544602,3911,,affects,,Lansoprazole,,,,peptic ulcer disease,,,,, +11547923,3912,,affects,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +10008124,3913,,affects,,Lansoprazole,,,,peptic esophagitis,,,,, +7314434,3914,,affects,,Lansoprazole,,,,Helicobacter pylori infectious disease,,,,, +9466998,3915,,disrupts,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +20033093,3916,,prevents,,Lansoprazole,,,,peptic ulcer disease,,,,, +15339719,3917,,prevents,,Lansoprazole,,,,duodenal ulcer,,,,, +9335785,3918,,prevents,,Lansoprazole,,,,gastric ulcer,,,,, +8183428,3919,,prevents,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +27664803,3920,,exacerbates,,Lansoprazole,,,,gastritis,,,,, +10008126,3921,,predisposes,,Lansoprazole,,,,gastroesophageal reflux disease,,,,, +10345128,3922,,subclass of,,Omeprazole,,,,Omeprazole sulfone,,,,, +8512321,3923,,subclass of,,Omeprazole,,,,Hydroxyomeprazole,,,,, +27115212,3924,,related to,,Omeprazole,,,,Omeprazole sulfone,,,,, +12365583,3925,,related to,,Omeprazole,,,,gastric ulcer,,,,, +7744216,3926,,related to,,Omeprazole,,,,Hydroxyomeprazole,,,,, +26722672,3927,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, +9932953,3928,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, +22198908,3929,,physically interacts with,,Omeprazole,,,,Omeprazole sulfone,,,,, +13085286,3930,,physically interacts with,,Omeprazole,,,,Hydroxyomeprazole,,,,, +27703677,3931,,causes,,Omeprazole,,,,anemia,,,,, +27298440,3932,,causes,,Omeprazole,,,,Hemorrhage,,,,, +24514538,3933,,causes,,Omeprazole,,,,peptic ulcer disease,,,,, +19641302,3934,,causes,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +15956000,3935,,causes,,Omeprazole,,,,esophagitis,,,,, +12187782,3936,,causes,,Omeprazole,,,,ulcer disease,,,,, +11135889,3937,,causes,,Omeprazole,,,,injury,,,,, +10813876,3938,,causes,,Omeprazole,,,,Cough,,,,, +8871402,3939,,causes,,Omeprazole,,,,gastric ulcer,,,,, +7272148,3940,,causes,,Omeprazole,,,,duodenal ulcer,,,,, +27758339,3941,,affects,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, +27758338,3942,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, +27758337,3943,,affects,,Omeprazole,,,,peptic esophagitis,,,,, +27733079,3944,,affects,,Omeprazole,,,,peptic esophagitis,,,,, +27346919,3945,,affects,,Omeprazole,,,,peptic ulcer disease,,,,, +22440533,3946,,affects,,Omeprazole,,,,anemia,,,,, +18634760,3947,,affects,,Omeprazole,,,,Pain,,,,, +17967745,3948,,affects,,Omeprazole,,,,injury,,,,, +12114858,3949,,affects,,Omeprazole,,,,ulcer disease,,,,, +11576921,3950,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, +10321262,3951,,affects,,Omeprazole,,,,duodenal ulcer,,,,, +9976497,3952,,affects,,Omeprazole,,,,gastric ulcer,,,,, +8694897,3953,,affects,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, +8349380,3954,,affects,,Omeprazole,,,,Hemorrhage,,,,, +8349375,3955,,affects,,Omeprazole,,,,Hemorrhage,,,,, +7653505,3956,,affects,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +7572363,3957,,affects,,Omeprazole,,,,ulcer disease,,,,, +14345083,3958,,affects,,Omeprazole,,,,Hydroxyomeprazole,,,,, +26726289,3959,,disrupts,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +26000029,3960,,disrupts,,Omeprazole,,,,Zollinger-Ellison syndrome,,,,, +20129793,3961,,disrupts,,Omeprazole,,,,Barrett esophagus,,,,, +19299462,3962,,disrupts,,Omeprazole,,,,active peptic ulcer disease,,,,, +15524012,3963,,disrupts,,Omeprazole,,,,peptic ulcer disease,,,,, +13078646,3964,,disrupts,,Omeprazole,,,,ulcer disease,,,,, +10891179,3965,,disrupts,,Omeprazole,,,,gastric ulcer,,,,, +10776897,3966,,disrupts,,Omeprazole,,,,duodenal ulcer,,,,, +8884340,3967,,disrupts,,Omeprazole,,,,esophagitis,,,,, +27690262,3968,,prevents,,Omeprazole,,,,Helicobacter pylori infectious disease,,,,, +27025148,3969,,prevents,,Omeprazole,,,,Cough,,,,, +26715213,3970,,prevents,,Omeprazole,,,,Pain,,,,, +16929638,3971,,prevents,,Omeprazole,,,,esophagitis,,,,, +15601042,3972,,prevents,,Omeprazole,,,,active peptic ulcer disease,,,,, +9292674,3973,,prevents,,Omeprazole,,,,peptic ulcer disease,,,,, +8884338,3974,,prevents,,Omeprazole,,,,peptic esophagitis,,,,, +8341772,3975,,prevents,,Omeprazole,,,,duodenal ulcer,,,,, +8169375,3976,,prevents,,Omeprazole,,,,injury,,,,, +7646984,3977,,prevents,,Omeprazole,,,,gastric ulcer,,,,, +7653510,3978,,prevents,,Omeprazole,,,,gastroesophageal reflux disease,,,,, +7332307,3979,,prevents,,Omeprazole,,,,ulcer disease,,,,, +24752030,3980,,predisposes,,Omeprazole,,,,type 2 diabetes mellitus,,,,, +21309680,3981,,predisposes,,Omeprazole,,,,melanoma,,,,, +20838741,3982,,predisposes,,Omeprazole,,,,Barrett esophagus,,,,, +12649375,3983,,affects,,Rabeprazole,,,,infectious disease,,,,, +11547924,3984,,affects,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, +15461842,3985,,disrupts,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, +16244495,3986,,prevents,,Rabeprazole,,,,peptic ulcer disease,,,,, +15354267,3987,,prevents,,Rabeprazole,,,,active peptic ulcer disease,,,,, +8397732,3988,,prevents,,Rabeprazole,,,,gastroesophageal reflux disease,,,,, +23526790,3989,,causes,,Esomeprazole,,,,active peptic ulcer disease,,,,, +20333475,3990,,causes,,Esomeprazole,,,,preeclampsia,,,,, +15271081,3991,,causes,,Esomeprazole,,,,gastric ulcer,,,,, +22638872,3992,,affects,,Esomeprazole,,,,neoplasm,,,,, +20180848,3993,,affects,,Esomeprazole,,,,preeclampsia,,,,, +19360632,3994,,affects,,Esomeprazole,,,,ulcer disease,,,,, +18357402,3995,,affects,,Esomeprazole,,,,dyspepsia,,,,, +14247859,3996,,affects,,Esomeprazole,,,,gastric ulcer,,,,, +12902689,3997,,affects,,Esomeprazole,,,,Hemorrhage,,,,, +12902688,3998,,affects,,Esomeprazole,,,,Hemorrhage,,,,, +12527967,3999,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +12015567,4000,,affects,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +10805094,4001,,disrupts,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +15938697,4002,,prevents,,Esomeprazole,,,,gastric ulcer,,,,, +14015294,4003,,prevents,,Esomeprazole,,,,gastroesophageal reflux disease,,,,, +13576722,4004,,prevents,,Esomeprazole,,,,peptic ulcer disease,,,,, +12321750,4005,,prevents,,Esomeprazole,,,,ulcer disease,,,,, +10396538,4006,,related to,,Roflumilast,,,,asthma,,,,, +21017284,4007,,causes,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, +21116198,4008,,affects,,Roflumilast,,,,obesity disorder,,,,, +12290110,4009,,affects,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, +12290109,4010,,affects,,Roflumilast,,,,asthma,,,,, +22432515,4011,,disrupts,,Roflumilast,,,,schizophrenia,,,,, +24502817,4012,,prevents,,Roflumilast,,,,obesity disorder,,,,, +17763098,4013,,prevents,,Roflumilast,,,,diabetic kidney disease,,,,, +15955656,4014,,prevents,,Roflumilast,,,,chronic obstructive pulmonary disease,,,,, +8310806,4015,,causes,,Meperidine,,,,Pain,,,,, +26434893,4016,,affects,,Meperidine,,,,Pain,,,,, +18658715,4017,,affects,,Meperidine,,,,Pain,,,,, +8345324,4018,,prevents,,Meperidine,,,,Pain,,,,, +21672389,4019,,affects,,Ketobemidone,,,,Pain,,,,, +11850764,4020,,related to,,Travoprost,,,,ocular hypertension,,,,, +12116829,4021,,physically interacts with,,Travoprost,,,,prostanoid FP receptor,,,,, +18294152,4022,,affects,,Travoprost,,,,ocular hypertension,,,,, +18294151,4023,,affects,,Travoprost,,,,glaucoma,,,,, +10166996,4024,,prevents,,Travoprost,,,,ocular hypertension,,,,, +10166995,4025,,prevents,,Travoprost,,,,open-angle glaucoma,,,,, +17904574,4026,,related to,,Tafluprost,,,,glaucoma,,,,, +15304153,4027,,related to,,Tafluprost,,,,ocular hypertension,,,,, +15304152,4028,,related to,,Tafluprost,,,,open-angle glaucoma,,,,, +14941475,4029,,physically interacts with,,Tafluprost,,,,prostanoid FP receptor,,,,, +14941474,4030,,disrupts,,Tafluprost,,,,ocular hypertension,,,,, +14941473,4031,,disrupts,,Tafluprost,,,,open-angle glaucoma,,,,, +14231277,4032,,affects,,Ramelteon,,,,insomnia,,,,, +21718213,4033,,prevents,,Ramelteon,,,,sleep-wake disorder,,,,, +22873470,4034,,related to,,Melatonin,,,,acute kidney failure,,,,, +22002909,4035,,related to,,Melatonin,,,,metabolic disease,,,,, +21777340,4036,,related to,,Melatonin,,,,Cognitive impairment,,,,, +18920431,4037,,related to,,Melatonin,,,,burn,,,,, +18846352,4038,,related to,,Melatonin,,,,skin disorder,,,,, +18613354,4039,,related to,,Melatonin,,,,Neonatal sepsis,,,,, +18189253,4040,,related to,,Melatonin,,,,necrotizing enterocolitis,,,,, +17471678,4041,,related to,,Melatonin,,,,"dermatitis, atopic",,,,, +17103445,4042,,related to,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, +16423098,4043,,related to,,Melatonin,,,,periodontitis,,,,, +16022569,4044,,related to,,Melatonin,,,,metabolic syndrome X,,,,, +15882605,4045,,related to,,Melatonin,,,,enuresis,,,,, +15709123,4046,,related to,,Melatonin,,,,fibromyalgia,,,,, +15665905,4047,,related to,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, +14933527,4048,,related to,,Melatonin,,,,autism spectrum disorder,,,,, +14875890,4049,,related to,,Melatonin,,,,pervasive developmental disorder,,,,, +14786958,4050,,related to,,Melatonin,,,,gastroesophageal reflux disease,,,,, +13857052,4051,,related to,,Melatonin,,,,ulcerative colitis,,,,, +13491215,4052,,related to,,Melatonin,,,,diabetes mellitus,,,,, +13407170,4053,,related to,,Melatonin,,,,periodontal disorder,,,,, +13365823,4054,,related to,,Melatonin,,,,tooth disorder,,,,, +12843346,4055,,related to,,Melatonin,,,,melanoma,,,,, +12132104,4056,,related to,,Melatonin,,,,irritable bowel syndrome,,,,, +11584899,4057,,related to,,Melatonin,,,,brain ischemia,,,,, +11533403,4058,,related to,,Melatonin,,,,hypertensive disorder,,,,, +11319171,4059,,related to,,Melatonin,,,,Pain,,,,, +11137637,4060,,related to,,Melatonin,,,,essential hypertension,,,,, +10685850,4061,,related to,,Melatonin,,,,major depressive disorder,,,,, +10528037,4062,,related to,,Melatonin,,,,multiple sclerosis,,,,, +10477010,4063,,related to,,Melatonin,,,,non-small cell lung carcinoma,,,,, +10371972,4064,,related to,,Melatonin,,,,delirium,,,,, +10204563,4065,,related to,,Melatonin,,,,depressive disorder,,,,, +9947492,4066,,related to,,Melatonin,,,,myocardial infarction,,,,, +9516882,4067,,related to,,Melatonin,,,,Parkinson disease,,,,, +9086006,4068,,related to,,Melatonin,,,,ischemia reperfusion injury,,,,, +9074687,4069,,related to,,Melatonin,,,,Sepsis,,,,, +8867365,4070,,related to,,Melatonin,,,,schizophrenia,,,,, +8780387,4071,,related to,,Melatonin,,,,insomnia,,,,, +8686098,4072,,related to,,Melatonin,,,,dementia,,,,, +8623112,4073,,related to,,Melatonin,,,,migraine disorder,,,,, +7795396,4074,,related to,,Melatonin,,,,injury,,,,, +7482169,4075,,related to,,Melatonin,,,,neoplasm,,,,, +7440685,4076,,related to,,Melatonin,,,,Fatigue,,,,, +7185935,4077,,related to,,Melatonin,,,,epilepsy,,,,, +7185921,4078,,related to,,Melatonin,,,,sleep-wake disorder,,,,, +26987553,4079,,causes,,Melatonin,,,,Fatigue,,,,, +24500836,4080,,causes,,Melatonin,,,,anxiety,,,,, +22662368,4081,,causes,,Melatonin,,,,dementia,,,,, +21258564,4082,,causes,,Melatonin,,,,multiple sclerosis,,,,, +19886996,4083,,causes,,Melatonin,,,,Cognitive impairment,,,,, +19573910,4084,,causes,,Melatonin,,,,periodontitis,,,,, +17837306,4085,,causes,,Melatonin,,,,metabolic disease,,,,, +17714427,4086,,causes,,Melatonin,,,,myocardial infarction,,,,, +16705153,4087,,causes,,Melatonin,,,,Sepsis,,,,, +15644359,4088,,causes,,Melatonin,,,,gastroesophageal reflux disease,,,,, +14831403,4089,,causes,,Melatonin,,,,periodontal disorder,,,,, +14171289,4090,,causes,,Melatonin,,,,Parkinson disease,,,,, +14078373,4091,,causes,,Melatonin,,,,hypertensive disorder,,,,, +13896033,4092,,causes,,Melatonin,,,,breast neoplasm,,,,, +13361926,4093,,causes,,Melatonin,,,,ischemia reperfusion injury,,,,, +13039360,4094,,causes,,Melatonin,,,,epilepsy,,,,, +12762592,4095,,causes,,Melatonin,,,,enuresis,,,,, +12275569,4096,,causes,,Melatonin,,,,diabetes mellitus,,,,, +12071557,4097,,causes,,Melatonin,,,,insomnia,,,,, +10432083,4098,,causes,,Melatonin,,,,migraine disorder,,,,, +10432067,4099,,causes,,Melatonin,,,,schizophrenia,,,,, +9114525,4100,,causes,,Melatonin,,,,neoplasm,,,,, +8785660,4101,,causes,,Melatonin,,,,depressive disorder,,,,, +8291971,4102,,causes,,Melatonin,,,,injury,,,,, +25620630,4103,,affects,,Melatonin,,,,Fatigue,,,,, +25259613,4104,,affects,,Melatonin,,,,atrial fibrillation,,,,, +24144792,4105,,affects,,Melatonin,,,,myocardial infarction,,,,, +24094187,4106,,affects,,Melatonin,,,,major depressive disorder,,,,, +23101890,4107,,affects,,Melatonin,,,,periodontitis,,,,, +22037016,4108,,affects,,Melatonin,,,,diabetes mellitus,,,,, +21523229,4109,,affects,,Melatonin,,,,anxiety,,,,, +21046382,4110,,affects,,Melatonin,,,,non-small cell lung carcinoma,,,,, +20888328,4111,,affects,,Melatonin,,,,autism spectrum disorder,,,,, +18858036,4112,,affects,,Melatonin,,,,Cognitive impairment,,,,, +18703578,4113,,affects,,Melatonin,,,,Marchiafava-Bignami disease,,,,, +18605461,4114,,affects,,Melatonin,,,,Neonatal sepsis,,,,, +18605459,4115,,affects,,Melatonin,,,,Neonatal sepsis,,,,, +18111864,4116,,affects,,Melatonin,,,,Hemorrhage,,,,, +17774103,4117,,affects,,Melatonin,,,,fibromyalgia,,,,, +17471677,4118,,affects,,Melatonin,,,,"dermatitis, atopic",,,,, +17402992,4119,,affects,,Melatonin,,,,Fatigue,,,,, +17199486,4120,,affects,,Melatonin,,,,Sepsis,,,,, +17103446,4121,,affects,,Melatonin,,,,obstructive sleep apnea syndrome,,,,, +17112614,4122,,affects,,Melatonin,,,,ulcerative colitis,,,,, +16898660,4123,,affects,,Melatonin,,,,Cognitive impairment,,,,, +16300651,4124,,affects,,Melatonin,,,,depressive disorder,,,,, +16293202,4125,,affects,,Melatonin,,,,Hemorrhage,,,,, +16189615,4126,,affects,,Melatonin,,,,Cognitive impairment,,,,, +15390003,4127,,affects,,Melatonin,,,,delirium,,,,, +14400565,4128,,affects,,Melatonin,,,,burn,,,,, +14333232,4129,,affects,,Melatonin,,,,schizophrenia,,,,, +13430046,4130,,affects,,Melatonin,,,,epilepsy,,,,, +13158859,4131,,affects,,Melatonin,,,,tooth disorder,,,,, +12620684,4132,,affects,,Melatonin,,,,melanoma,,,,, +12473519,4133,,affects,,Melatonin,,,,Parkinson disease,,,,, +11739216,4134,,affects,,Melatonin,,,,sleep-wake disorder,,,,, +11451669,4135,,affects,,Melatonin,,,,depressive disorder,,,,, +10979770,4136,,affects,,Melatonin,,,,insomnia,,,,, +10516034,4137,,affects,,Melatonin,,,,Pain,,,,, +10432086,4138,,affects,,Melatonin,,,,multiple sclerosis,,,,, +10047665,4139,,affects,,Melatonin,,,,hypertensive disorder,,,,, +9535418,4140,,affects,,Melatonin,,,,injury,,,,, +9364224,4141,,affects,,Melatonin,,,,Pain,,,,, +9244581,4142,,affects,,Melatonin,,,,migraine disorder,,,,, +9153135,4143,,affects,,Melatonin,,,,diabetes mellitus,,,,, +9143737,4144,,affects,,Melatonin,,,,epilepsy,,,,, +9114510,4145,,affects,,Melatonin,,,,ischemia reperfusion injury,,,,, +8993003,4146,,affects,,Melatonin,,,,neoplasm,,,,, +8720758,4147,,affects,,Melatonin,,,,breast neoplasm,,,,, +8108047,4148,,affects,,Melatonin,,,,depressive disorder,,,,, +7564928,4149,,affects,,Melatonin,,,,neoplasm,,,,, +7382212,4150,,affects,,Melatonin,,,,brain ischemia,,,,, +26765396,4151,,produces,,Melatonin,,,,epilepsy,,,,, +22867260,4152,,produces,,Melatonin,,,,diabetes mellitus,,,,, +18240585,4153,,produces,,Melatonin,,,,ulcerative colitis,,,,, +17207380,4154,,produces,,Melatonin,,,,autism spectrum disorder,,,,, +17051558,4155,,produces,,Melatonin,,,,depressive disorder,,,,, +16192357,4156,,produces,,Melatonin,,,,sleep-wake disorder,,,,, +13817260,4157,,produces,,Melatonin,,,,Parkinson disease,,,,, +11388402,4158,,produces,,Melatonin,,,,neoplasm,,,,, +9153153,4159,,produces,,Melatonin,,,,hypertensive disorder,,,,, +8191029,4160,,produces,,Melatonin,,,,breast neoplasm,,,,, +24623673,4161,,disrupts,,Melatonin,,,,atrial fibrillation,,,,, +24220852,4162,,disrupts,,Melatonin,,,,metabolic disease,,,,, +22817547,4163,,disrupts,,Melatonin,,,,anxiety,,,,, +20966258,4164,,disrupts,,Melatonin,,,,Cognitive impairment,,,,, +20623050,4165,,disrupts,,Melatonin,,,,"attention deficit hyperactivity disorder, inattentive type",,,,, +19958338,4166,,disrupts,,Melatonin,,,,multiple sclerosis,,,,, +18007482,4167,,disrupts,,Melatonin,,,,Sepsis,,,,, +18002672,4168,,disrupts,,Melatonin,,,,Pain,,,,, +16753621,4169,,disrupts,,Melatonin,,,,sleep-wake disorder,,,,, +14914180,4170,,disrupts,,Melatonin,,,,melanoma,,,,, +14617999,4171,,disrupts,,Melatonin,,,,"dermatitis, atopic",,,,, +13855513,4172,,disrupts,,Melatonin,,,,Hemorrhage,,,,, +10721769,4173,,disrupts,,Melatonin,,,,depressive disorder,,,,, +10333555,4174,,disrupts,,Melatonin,,,,injury,,,,, +10294227,4175,,disrupts,,Melatonin,,,,breast neoplasm,,,,, +10070181,4176,,disrupts,,Melatonin,,,,brain ischemia,,,,, +10008170,4177,,disrupts,,Melatonin,,,,Marchiafava-Bignami disease,,,,, +8932328,4178,,disrupts,,Melatonin,,,,epilepsy,,,,, +7916082,4179,,disrupts,,Melatonin,,,,ischemia reperfusion injury,,,,, +7545973,4180,,disrupts,,Melatonin,,,,neoplasm,,,,, +24902716,4181,,prevents,,Melatonin,,,,stomatitis,,,,, +24687342,4182,,prevents,,Melatonin,,,,essential hypertension,,,,, +24623674,4183,,prevents,,Melatonin,,,,atrial fibrillation,,,,, +24368351,4184,,prevents,,Melatonin,,,,acute kidney failure,,,,, +23824121,4185,,prevents,,Melatonin,,,,dementia,,,,, +23122960,4186,,prevents,,Melatonin,,,,Cognitive impairment,,,,, +22817548,4187,,prevents,,Melatonin,,,,anxiety,,,,, +21718214,4188,,prevents,,Melatonin,,,,sleep-wake disorder,,,,, +20260777,4189,,prevents,,Melatonin,,,,Pain,,,,, +19640170,4190,,prevents,,Melatonin,,,,aortic aneurysm,,,,, +18396849,4191,,prevents,,Melatonin,,,,Sepsis,,,,, +18141997,4192,,prevents,,Melatonin,,,,metabolic disease,,,,, +16995162,4193,,prevents,,Melatonin,,,,metabolic syndrome X,,,,, +16549748,4194,,prevents,,Melatonin,,,,burn,,,,, +16245777,4195,,prevents,,Melatonin,,,,schizophrenia,,,,, +16232642,4196,,prevents,,Melatonin,,,,Marchiafava-Bignami disease,,,,, +15150085,4197,,prevents,,Melatonin,,,,depressive disorder,,,,, +14373042,4198,,prevents,,Melatonin,,,,Parkinson disease,,,,, +11616466,4199,,prevents,,Melatonin,,,,autism spectrum disorder,,,,, +11366467,4200,,prevents,,Melatonin,,,,migraine disorder,,,,, +11108260,4201,,prevents,,Melatonin,,,,hypertensive disorder,,,,, +11061121,4202,,prevents,,Melatonin,,,,insomnia,,,,, +10234923,4203,,prevents,,Melatonin,,,,breast neoplasm,,,,, +10127047,4204,,prevents,,Melatonin,,,,myocardial infarction,,,,, +9561452,4205,,prevents,,Melatonin,,,,diabetes mellitus,,,,, +9346845,4206,,prevents,,Melatonin,,,,delirium,,,,, +9336280,4207,,prevents,,Melatonin,,,,brain ischemia,,,,, +8678642,4208,,prevents,,Melatonin,,,,epilepsy,,,,, +8166782,4209,,prevents,,Melatonin,,,,ischemia reperfusion injury,,,,, +7622774,4210,,prevents,,Melatonin,,,,injury,,,,, +7545974,4211,,prevents,,Melatonin,,,,neoplasm,,,,, +19276524,4212,,exacerbates,,Melatonin,,,,diabetes mellitus,,,,, +7980097,4213,,exacerbates,,Melatonin,,,,brain ischemia,,,,, +27283551,4214,,predisposes,,Melatonin,,,,hypertensive disorder,,,,, +23266236,4215,,predisposes,,Melatonin,,,,epilepsy,,,,, +21026194,4216,,predisposes,,Melatonin,,,,migraine disorder,,,,, +20835242,4217,,predisposes,,Melatonin,,,,metabolic syndrome X,,,,, +20419573,4218,,predisposes,,Melatonin,,,,major depressive disorder,,,,, +19382519,4219,,predisposes,,Melatonin,,,,periodontal disorder,,,,, +18749948,4220,,predisposes,,Melatonin,,,,autism spectrum disorder,,,,, +18605458,4221,,predisposes,,Melatonin,,,,Neonatal sepsis,,,,, +18359560,4222,,predisposes,,Melatonin,,,,depressive disorder,,,,, +16852096,4223,,predisposes,,Melatonin,,,,diabetes mellitus,,,,, +15094135,4224,,predisposes,,Melatonin,,,,injury,,,,, +14875892,4225,,predisposes,,Melatonin,,,,pervasive developmental disorder,,,,, +11794031,4226,,predisposes,,Melatonin,,,,neoplasm,,,,, +11643546,4227,,predisposes,,Melatonin,,,,dementia,,,,, +10915746,4228,,predisposes,,Melatonin,,,,sleep-wake disorder,,,,, +10114913,4229,,predisposes,,Melatonin,,,,myocardial infarction,,,,, +12950718,4230,,related to,,RETEPLASE,,,,thrombotic disease,,,,, +7082056,4231,,related to,,RETEPLASE,,,,stroke disorder,,,,, +12026281,4232,,related to,,UROKINASE,,,,stroke disorder,,,,, +11808316,4233,,related to,,UROKINASE,,,,empyema,,,,, +9909017,4234,,related to,,UROKINASE,,,,pleural empyema,,,,, +9695495,4235,,related to,,UROKINASE,,,,thrombotic disease,,,,, +7757067,4236,,related to,,UROKINASE,,,,pulmonary embolism,,,,, +20949144,4237,,causes,,UROKINASE,,,,thrombotic disease,,,,, +7392657,4238,,causes,,UROKINASE,,,,pulmonary embolism,,,,, +26135964,4239,,affects,,UROKINASE,,,,pulmonary embolism,,,,, +25781305,4240,,affects,,UROKINASE,,,,thrombotic disease,,,,, +26885635,4241,,disrupts,,UROKINASE,,,,thrombotic disease,,,,, +11607211,4242,,prevents,,UROKINASE,,,,thrombotic disease,,,,, +8505599,4243,,prevents,,UROKINASE,,,,pulmonary embolism,,,,, +26334889,4244,,predisposes,,UROKINASE,,,,pulmonary embolism,,,,, +13797160,4245,,predisposes,,UROKINASE,,,,thrombotic disease,,,,, +13590349,4246,,causes,,Buspirone,,,,depressive disorder,,,,, +7712722,4247,,affects,,Buspirone,,,,depressive disorder,,,,, +7425584,4248,,affects,,Buspirone,,,,physiological sexual disorder,,,,, +19950288,4249,,disrupts,,Buspirone,,,,schizophrenia,,,,, +10992881,4250,,disrupts,,Buspirone,,,,anxiety,,,,, +19904227,4251,,related to,,Iodine,,,,thyroid tumor,,,,, +10048388,4252,,related to,,Iodine,,,,breast neoplasm,,,,, +10651106,4253,,causes,,Iodine,,,,thyroid tumor,,,,, +10745802,4254,,affects,,Iodine,,,,thyroid tumor,,,,, +24773674,4255,,prevents,,Iodine,,,,thyroid tumor,,,,, +27167996,4256,,predisposes,,Iodine,,,,thyroid tumor,,,,, +7362584,4257,,subclass of,,Acetaminophen,,,,Acetaminophen sulfate,,,,, +7362582,4258,,subclass of,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +26133523,4259,,related to,,Acetaminophen,,,,neoplasm,,,,, +25084939,4260,,related to,,Acetaminophen,,,,Acetimidoquinone,,,,, +24055705,4261,,related to,,Acetaminophen,,,,osteoarthritis,,,,, +20371329,4262,,related to,,Acetaminophen,,,,digestive system disorder,,,,, +19637295,4263,,related to,,Acetaminophen,,,,Renal Colic,,,,, +16009572,4264,,related to,,Acetaminophen,,,,rheumatoid arthritis,,,,, +12233599,4265,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +12541409,4266,,related to,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +15777318,4267,,coexists with,,Acetaminophen,,,,Acetimidoquinone,,,,, +18513016,4268,,derives from,,Acetaminophen,,,,Acetimidoquinone,,,,, +16596646,4269,,derives from,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +7891577,4270,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, +11100770,4271,,physically interacts with,,Acetaminophen,,,,Acetimidoquinone,,,,, +8441876,4272,,physically interacts with,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +25685005,4273,,causes,,Acetaminophen,,,,neoplasm,,,,, +24327037,4274,,causes,,Acetaminophen,,,,anxiety,,,,, +23482103,4275,,causes,,Acetaminophen,,,,nervous system disorder,,,,, +21920646,4276,,causes,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, +21160030,4277,,causes,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, +19409287,4278,,causes,,Acetaminophen,,,,myopia,,,,, +17485084,4279,,causes,,Acetaminophen,,,,obesity disorder,,,,, +17093716,4280,,causes,,Acetaminophen,,,,kidney disorder,,,,, +16903597,4281,,causes,,Acetaminophen,,,,hypertensive disorder,,,,, +16867510,4282,,causes,,Acetaminophen,,,,delirium,,,,, +16756158,4283,,causes,,Acetaminophen,,,,osteoarthritis,,,,, +16155885,4284,,causes,,Acetaminophen,,,,Hemorrhage,,,,, +15922778,4285,,causes,,Acetaminophen,,,,Pruritus,,,,, +14972793,4286,,causes,,Acetaminophen,,,,brain injury,,,,, +12302511,4287,,causes,,Acetaminophen,,,,Headache,,,,, +9507087,4288,,causes,,Acetaminophen,,,,Vomiting,,,,, +8697178,4289,,causes,,Acetaminophen,,,,Pain,,,,, +8697177,4290,,causes,,Acetaminophen,,,,Fever,,,,, +7330301,4291,,causes,,Acetaminophen,,,,injury,,,,, +24793249,4292,,affects,,Acetaminophen,,,,hypertensive disorder,,,,, +23912807,4293,,affects,,Acetaminophen,,,,Vomiting,,,,, +23912806,4294,,affects,,Acetaminophen,,,,Nausea,,,,, +23442508,4295,,affects,,Acetaminophen,,,,pharyngitis,,,,, +23226380,4296,,affects,,Acetaminophen,,,,anxiety,,,,, +22849168,4297,,affects,,Acetaminophen,,,,neoplasm,,,,, +22389406,4298,,affects,,Acetaminophen,,,,Low back pain,,,,, +22267005,4299,,affects,,Acetaminophen,,,,Acute Pain,,,,, +21609859,4300,,affects,,Acetaminophen,,,,migraine disorder,,,,, +21375424,4301,,affects,,Acetaminophen,,,,preeclampsia,,,,, +21166764,4302,,affects,,Acetaminophen,,,,Parkinson disease,,,,, +20477729,4303,,affects,,Acetaminophen,,,,Hemorrhage,,,,, +20447454,4304,,affects,,Acetaminophen,,,,rheumatoid arthritis,,,,, +19937801,4305,,affects,,Acetaminophen,,,,Pain,,,,, +19285056,4306,,affects,,Acetaminophen,,,,Renal Colic,,,,, +18899993,4307,,affects,,Acetaminophen,,,,Abdominal pain,,,,, +18709599,4308,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, +18394888,4309,,affects,,Acetaminophen,,,,Headache,,,,, +18298999,4310,,affects,,Acetaminophen,,,,patent ductus arteriosus,,,,, +16707575,4311,,affects,,Acetaminophen,,,,obesity disorder,,,,, +16662805,4312,,affects,,Acetaminophen,,,,Vomiting,,,,, +16662804,4313,,affects,,Acetaminophen,,,,Nausea,,,,, +15922777,4314,,affects,,Acetaminophen,,,,Pruritus,,,,, +15909356,4315,,affects,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, +12673406,4316,,affects,,Acetaminophen,,,,bone fracture,,,,, +12488756,4317,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +11625632,4318,,affects,,Acetaminophen,,,,Chronic pain,,,,, +11439823,4319,,affects,,Acetaminophen,,,,type 1 diabetes mellitus,,,,, +11319146,4320,,affects,,Acetaminophen,,,,neuralgia,,,,, +11289717,4321,,affects,,Acetaminophen,,,,osteoarthritis,,,,, +11227783,4322,,affects,,Acetaminophen,,,,Fever,,,,, +11159989,4323,,affects,,Acetaminophen,,,,Hemorrhage,,,,, +10410536,4324,,affects,,Acetaminophen,,,,injury,,,,, +10195419,4325,,affects,,Acetaminophen,,,,Pain,,,,, +9259287,4326,,affects,,Acetaminophen,,,,Fever,,,,, +8642669,4327,,affects,,Acetaminophen,,,,Hemorrhage,,,,, +8097597,4328,,affects,,Acetaminophen,,,,injury,,,,, +25639149,4329,,affects,,Acetaminophen,,,,Acetaminophen glucuronide,,,,, +20782169,4330,,affects,,Acetaminophen,,,,Acetimidoquinone,,,,, +25481457,4331,,disrupts,,Acetaminophen,,,,patent ductus arteriosus,,,,, +25355292,4332,,disrupts,,Acetaminophen,,,,delirium,,,,, +19614622,4333,,disrupts,,Acetaminophen,,,,Headache,,,,, +16273113,4334,,disrupts,,Acetaminophen,,,,Fever,,,,, +12102031,4335,,disrupts,,Acetaminophen,,,,Pain,,,,, +7794905,4336,,disrupts,,Acetaminophen,,,,influenza,,,,, +7640332,4337,,disrupts,,Acetaminophen,,,,injury,,,,, +26559635,4338,,prevents,,Acetaminophen,,,,malaria,,,,, +22159381,4339,,prevents,,Acetaminophen,,,,Hemorrhage,,,,, +22123298,4340,,prevents,,Acetaminophen,,,,Fever,,,,, +20154151,4341,,prevents,,Acetaminophen,,,,neuralgia,,,,, +20107193,4342,,prevents,,Acetaminophen,,,,delirium,,,,, +19168014,4343,,prevents,,Acetaminophen,,,,obesity disorder,,,,, +19006111,4344,,prevents,,Acetaminophen,,,,patent ductus arteriosus,,,,, +18131378,4345,,prevents,,Acetaminophen,,,,Low back pain,,,,, +18033682,4346,,prevents,,Acetaminophen,,,,Vomiting,,,,, +16975983,4347,,prevents,,Acetaminophen,,,,neoplasm,,,,, +16828191,4348,,prevents,,Acetaminophen,,,,rheumatoid arthritis,,,,, +16784082,4349,,prevents,,Acetaminophen,,,,injury,,,,, +16782348,4350,,prevents,,Acetaminophen,,,,Nausea,,,,, +15909357,4351,,prevents,,Acetaminophen,,,,Postoperative Nausea and Vomiting,,,,, +15525446,4352,,prevents,,Acetaminophen,,,,Acute Pain,,,,, +15467414,4353,,prevents,,Acetaminophen,,,,influenza,,,,, +14660734,4354,,prevents,,Acetaminophen,,,,cardiac rhythm disease,,,,, +14372292,4355,,prevents,,Acetaminophen,,,,Headache,,,,, +13804263,4356,,prevents,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, +8695490,4357,,prevents,,Acetaminophen,,,,Pain,,,,, +25567880,4358,,predisposes,,Acetaminophen,,,,Sepsis,,,,, +24917204,4359,,predisposes,,Acetaminophen,,,,type 2 diabetes mellitus,,,,, +22230555,4360,,predisposes,,Acetaminophen,,,,delirium,,,,, +21723139,4361,,predisposes,,Acetaminophen,,,,Hemorrhage,,,,, +20594449,4362,,predisposes,,Acetaminophen,,,,neoplasm,,,,, +19914508,4363,,predisposes,,Acetaminophen,,,,Pain,,,,, +16209480,4364,,predisposes,,Acetaminophen,,,,kidney disorder,,,,, +13597848,4365,,predisposes,,Acetaminophen,,,,injury,,,,, +13536066,4366,,predisposes,,Acetaminophen,,,,non-small cell lung carcinoma,,,,, +12673403,4367,,predisposes,,Acetaminophen,,,,bone fracture,,,,, +12109634,4368,,predisposes,,Acetaminophen,,,,Parkinson disease,,,,, +11873681,4369,,predisposes,,Acetaminophen,,,,non-Hodgkin lymphoma,,,,, +9834508,4370,,predisposes,,Acetaminophen,,,,hypertensive disorder,,,,, +8862839,4371,,predisposes,,Acetaminophen,,,,streptococcal infection,,,,, +10289439,4372,,related to,,Chlorthalidone,,,,hypertensive disorder,,,,, +10185607,4373,,related to,,Chlorthalidone,,,,coronary artery disorder,,,,, +10185606,4374,,related to,,Chlorthalidone,,,,myocardial infarction,,,,, +7839079,4375,,related to,,Chlorthalidone,,,,essential hypertension,,,,, +21616164,4376,,affects,,Chlorthalidone,,,,myocardial infarction,,,,, +21616163,4377,,affects,,Chlorthalidone,,,,coronary artery disorder,,,,, +16399514,4378,,affects,,Chlorthalidone,,,,essential hypertension,,,,, +16281975,4379,,affects,,Chlorthalidone,,,,hypertensive disorder,,,,, +11587035,4380,,affects,,Chlorthalidone,,,,diabetes mellitus,,,,, +11095498,4381,,prevents,,Chlorthalidone,,,,myocardial infarction,,,,, +11095497,4382,,prevents,,Chlorthalidone,,,,coronary artery disorder,,,,, +8853238,4383,,prevents,,Chlorthalidone,,,,myocardial ischemia,,,,, +8036244,4384,,prevents,,Chlorthalidone,,,,hypertensive disorder,,,,, +11078982,4385,,predisposes,,Chlorthalidone,,,,coronary artery disorder,,,,, +19123757,4386,,causes,,Propacetamol,,,,Pain,,,,, +11402898,4387,,prevents,,Propacetamol,,,,Pain,,,,, +25540651,4388,,affects,,Isopropyl Alcohol,,,,Nausea,,,,, +18311094,4389,,affects,,Isopropyl Alcohol,,,,infectious disease,,,,, +10697335,4390,,affects,,Isopropyl Alcohol,,,,burn,,,,, +9427033,4391,,prevents,,Isopropyl Alcohol,,,,infectious disease,,,,, +21320482,4392,,related to,,Ethanol,,,,substance-related disorder,,,,, +15908919,4393,,related to,,Ethanol,,,,hypertensive disorder,,,,, +14538852,4394,,related to,,Ethanol,,,,atrial fibrillation,,,,, +13852361,4395,,related to,,Ethanol,,,,obesity disorder,,,,, +27116018,4396,,causes,,Ethanol,,,,neutropenia,,,,, +26520376,4397,,causes,,Ethanol,,,,essential hypertension,,,,, +17336935,4398,,causes,,Ethanol,,,,Tremor,,,,, +15073107,4399,,causes,,Ethanol,,,,alcohol-related disorders,,,,, +14779551,4400,,causes,,Ethanol,,,,burn,,,,, +12227250,4401,,causes,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, +11665347,4402,,causes,,Ethanol,,,,erectile dysfunction,,,,, +11096896,4403,,causes,,Ethanol,,,,type 2 diabetes mellitus,,,,, +10962858,4404,,causes,,Ethanol,,,,atrial fibrillation,,,,, +9159992,4405,,causes,,Ethanol,,,,obesity disorder,,,,, +8743651,4406,,causes,,Ethanol,,,,alcohol abuse,,,,, +8636726,4407,,causes,,Ethanol,,,,major depressive disorder,,,,, +8268450,4408,,causes,,Ethanol,,,,atopic eczema,,,,, +7771647,4409,,causes,,Ethanol,,,,hypertensive disorder,,,,, +7460012,4410,,causes,,Ethanol,,,,cirrhosis of liver,,,,, +27580478,4411,,affects,,Ethanol,,,,cirrhosis of liver,,,,, +27514790,4412,,affects,,Ethanol,,,,Thyroid nodule,,,,, +26762447,4413,,affects,,Ethanol,,,,neutropenia,,,,, +23912654,4414,,affects,,Ethanol,,,,atrial fibrillation,,,,, +23763968,4415,,affects,,Ethanol,,,,substance-related disorder,,,,, +19533165,4416,,affects,,Ethanol,,,,hypertensive disorder,,,,, +19155713,4417,,affects,,Ethanol,,,,cannabis dependence,,,,, +16819917,4418,,affects,,Ethanol,,,,Chronic pain,,,,, +15671844,4419,,affects,,Ethanol,,,,obesity disorder,,,,, +14737169,4420,,affects,,Ethanol,,,,Chronic pain,,,,, +14527564,4421,,affects,,Ethanol,,,,benign prostatic hyperplasia,,,,, +13226372,4422,,affects,,Ethanol,,,,atrial fibrillation,,,,, +12698965,4423,,affects,,Ethanol,,,,major depressive disorder,,,,, +12166837,4424,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, +10697334,4425,,affects,,Ethanol,,,,burn,,,,, +9822489,4426,,affects,,Ethanol,,,,Tremor,,,,, +9174558,4427,,affects,,Ethanol,,,,Tremor,,,,, +9116052,4428,,affects,,Ethanol,,,,major depressive disorder,,,,, +8931619,4429,,affects,,Ethanol,,,,hypertensive disorder,,,,, +8730041,4430,,affects,,Ethanol,,,,burn,,,,, +8616967,4431,,affects,,Ethanol,,,,type 2 diabetes mellitus,,,,, +8569555,4432,,affects,,Ethanol,,,,alcohol abuse,,,,, +8363507,4433,,affects,,Ethanol,,,,obesity disorder,,,,, +7210977,4434,,affects,,Ethanol,,,,alcohol abuse,,,,, +25366419,4435,,disrupts,,Ethanol,,,,ventricular tachycardia,,,,, +24747388,4436,,disrupts,,Ethanol,,,,obesity disorder,,,,, +22793590,4437,,disrupts,,Ethanol,,,,Infection,,,,, +20664067,4438,,disrupts,,Ethanol,,,,Chronic pain,,,,, +19084276,4439,,disrupts,,Ethanol,,,,hypertensive disorder,,,,, +15586620,4440,,disrupts,,Ethanol,,,,Tremor,,,,, +15580442,4441,,disrupts,,Ethanol,,,,atrial fibrillation,,,,, +12535146,4442,,disrupts,,Ethanol,,,,type 2 diabetes mellitus,,,,, +9920913,4443,,disrupts,,Ethanol,,,,constipation disorder,,,,, +27717904,4444,,prevents,,Ethanol,,,,cirrhosis of liver,,,,, +22976273,4445,,prevents,,Ethanol,,,,Infection,,,,, +21338360,4446,,prevents,,Ethanol,,,,atrial fibrillation,,,,, +20664068,4447,,prevents,,Ethanol,,,,Chronic pain,,,,, +14465260,4448,,prevents,,Ethanol,,,,bacterial infectious disease with sepsis,,,,, +13158318,4449,,prevents,,Ethanol,,,,erectile dysfunction,,,,, +12078103,4450,,prevents,,Ethanol,,,,alcohol abuse,,,,, +11890775,4451,,prevents,,Ethanol,,,,type 2 diabetes mellitus,,,,, +11547578,4452,,prevents,,Ethanol,,,,Tremor,,,,, +10032139,4453,,prevents,,Ethanol,,,,obesity disorder,,,,, +8207881,4454,,prevents,,Ethanol,,,,hypertensive disorder,,,,, +26228661,4455,,predisposes,,Ethanol,,,,essential hypertension,,,,, +23006394,4456,,predisposes,,Ethanol,,,,constipation disorder,,,,, +21458894,4457,,predisposes,,Ethanol,,,,burn,,,,, +21015200,4458,,predisposes,,Ethanol,,,,benign prostatic hyperplasia,,,,, +20014749,4459,,predisposes,,Ethanol,,,,neuroblastoma,,,,, +19550164,4460,,predisposes,,Ethanol,,,,endometriosis,,,,, +15239058,4461,,predisposes,,Ethanol,,,,cannabis dependence,,,,, +13742110,4462,,predisposes,,Ethanol,,,,cirrhosis of liver,,,,, +13158317,4463,,predisposes,,Ethanol,,,,erectile dysfunction,,,,, +11801709,4464,,predisposes,,Ethanol,,,,type 2 diabetes mellitus,,,,, +11652545,4465,,predisposes,,Ethanol,,,,obesity disorder,,,,, +11461204,4466,,predisposes,,Ethanol,,,,atrial fibrillation,,,,, +9864711,4467,,predisposes,,Ethanol,,,,major depressive disorder,,,,, +9226083,4468,,predisposes,,Ethanol,,,,alcohol abuse,,,,, +8895200,4469,,predisposes,,Ethanol,,,,hypertensive disorder,,,,, +22402878,4470,,related to,,Sodium Hypochlorite,,,,Infection,,,,, +22402879,4471,,prevents,,Sodium Hypochlorite,,,,Infection,,,,, +22325598,4472,,prevents,,Sodium Hypochlorite,,,,Pain,,,,, +23522159,4473,,related to,,Hydrogen Peroxide,,,,gingivitis,,,,, +10185817,4474,,related to,,Hydrogen Peroxide,,,,acne,,,,, +9091124,4475,,related to,,Hydrogen Peroxide,,,,injury,,,,, +21979927,4476,,causes,,Hydrogen Peroxide,,,,seborrheic keratosis,,,,, +7121153,4477,,causes,,Hydrogen Peroxide,,,,injury,,,,, +18988282,4478,,affects,,Hydrogen Peroxide,,,,severe acute respiratory syndrome,,,,, +15261236,4479,,affects,,Hydrogen Peroxide,,,,gingivitis,,,,, +9489971,4480,,affects,,Hydrogen Peroxide,,,,injury,,,,, +7188934,4481,,affects,,Hydrogen Peroxide,,,,injury,,,,, +20490056,4482,,disrupts,,Hydrogen Peroxide,,,,dental caries,,,,, +17081431,4483,,disrupts,,Hydrogen Peroxide,,,,injury,,,,, +8804977,4484,,disrupts,,Hydrogen Peroxide,,,,gingivitis,,,,, +21124110,4485,,prevents,,Hydrogen Peroxide,,,,acne,,,,, +11091070,4486,,prevents,,Hydrogen Peroxide,,,,gingivitis,,,,, +7482647,4487,,prevents,,Hydrogen Peroxide,,,,injury,,,,, +19925807,4488,,predisposes,,Hydrogen Peroxide,,,,dental caries,,,,, +10852631,4489,,predisposes,,Hydrogen Peroxide,,,,injury,,,,, +23181733,4490,,related to,,Vitamin K1,,,,Hemorrhage,,,,, +20221966,4491,,related to,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, +19764095,4492,,related to,,Vitamin K1,,,,osteoporosis,,,,, +17682094,4493,,related to,,Vitamin K1,,,,atrial fibrillation,,,,, +13777524,4494,,related to,,Vitamin K1,,,,cystic fibrosis,,,,, +11304774,4495,,affects,,Vitamin K1,,,,Hemorrhage,,,,, +24408540,4496,,prevents,,Vitamin K1,,,,Hemorrhage,,,,, +13476259,4497,,prevents,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, +10772424,4498,,predisposes,,Vitamin K1,,,,postmenopausal osteoporosis,,,,, +9319754,4499,,predisposes,,Vitamin K1,,,,vitamin K deficiency hemorrhagic disease,,,,, +24430542,4500,,causes,,Indapamide,,,,type 2 diabetes mellitus,,,,, +24430545,4501,,affects,,Indapamide,,,,type 2 diabetes mellitus,,,,, +10214767,4502,,affects,,Indapamide,,,,hypertensive disorder,,,,, +13327254,4503,,prevents,,Indapamide,,,,hypertensive disorder,,,,, +18173402,4504,,related to,,Perphenazine,,,,schizophrenia,,,,, +11307427,4505,,related to,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, +19924977,4506,,disrupts,,Perphenazine,,,,cocaine dependence,,,,, +19924976,4507,,disrupts,,Perphenazine,,,,schizophrenia,,,,, +15171439,4508,,prevents,,Perphenazine,,,,Postoperative Nausea and Vomiting,,,,, +27208453,4509,,exacerbates,,Perphenazine,,,,dementia,,,,, +26847530,4510,,affects,,Fluphenazine,,,,psychotic disorder,,,,, +11127872,4511,,prevents,,Fluphenazine,,,,psychotic disorder,,,,, +10396371,4512,,disrupts,,Prochlorperazine,,,,Nausea,,,,, +11808182,4513,,prevents,,Prochlorperazine,,,,Postoperative Nausea and Vomiting,,,,, +10634177,4514,,prevents,,Prochlorperazine,,,,migraine disorder,,,,, +7427448,4515,,prevents,,Prochlorperazine,,,,Nausea,,,,, +11272109,4516,,related to,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, +26291786,4517,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, +26291786,4518,,derives from,,ELOSULFASE ALFA,,,,Keratan,,,,, +16241796,4519,,physically interacts with,,ELOSULFASE ALFA,,,,Keratan,,,,, +16652816,4520,,causes,,ELOSULFASE ALFA,,,,mucopolysaccharidosis type 4,,,,, +13130107,4521,,affects,,ELOSULFASE ALFA,,,,Keratan,,,,, +21593588,4522,,related to,,Pegvaliase,,,,phenylketonuria,,,,, +23111774,4523,,related to,,Labetalol,,,,preeclampsia,,,,, +19865755,4524,,related to,,Labetalol,,,,hypertensive disorder,,,,, +19886747,4525,,causes,,Labetalol,,,,hypertensive disorder,,,,, +7968423,4526,,causes,,Labetalol,,,,hypotensive disorder,,,,, +26371124,4527,,affects,,Labetalol,,,,hypertensive disorder,,,,, +16245918,4528,,affects,,Labetalol,,,,stroke disorder,,,,, +15472186,4529,,affects,,Labetalol,,,,hypertensive disorder,,,,, +11424839,4530,,affects,,Labetalol,,,,hypotensive disorder,,,,, +24194004,4531,,prevents,,Labetalol,,,,preeclampsia,,,,, +16282554,4532,,prevents,,Labetalol,,,,hypertensive disorder,,,,, +16892434,4533,,predisposes,,Labetalol,,,,stroke disorder,,,,, +15232781,4534,,related to,,Carvedilol,,,,hypertensive disorder,,,,, +15407113,4535,,causes,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +14049404,4536,,causes,,Carvedilol,,,,epilepsy,,,,, +19046224,4537,,affects,,Carvedilol,,,,esophageal varices,,,,, +17542363,4538,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +11530189,4539,,affects,,Carvedilol,,,,essential hypertension,,,,, +11200172,4540,,affects,,Carvedilol,,,,atrial fibrillation,,,,, +10614289,4541,,affects,,Carvedilol,,,,Stable angina,,,,, +10614288,4542,,affects,,Carvedilol,,,,hypertensive disorder,,,,, +10402879,4543,,affects,,Carvedilol,,,,hypertensive disorder,,,,, +9269217,4544,,affects,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +9116913,4545,,affects,,Carvedilol,,,,cardiovascular disorder,,,,, +7256243,4546,,affects,,Carvedilol,,,,portal hypertension,,,,, +24587957,4547,,disrupts,,Carvedilol,,,,portal hypertension,,,,, +21108262,4548,,disrupts,,Carvedilol,,,,myocardial infarction,,,,, +13210472,4549,,disrupts,,Carvedilol,,,,atrial fibrillation,,,,, +23631897,4550,,prevents,,Carvedilol,,,,neoplasm,,,,, +23413400,4551,,prevents,,Carvedilol,,,,myocardial infarction,,,,, +20796578,4552,,prevents,,Carvedilol,,,,hypoglycemia,,,,, +17416516,4553,,prevents,,Carvedilol,,,,portal hypertension,,,,, +15996194,4554,,prevents,,Carvedilol,,,,hypertensive disorder,,,,, +15794060,4555,,prevents,,Carvedilol,,,,Abnormal left ventricular function,,,,, +15707001,4556,,prevents,,Carvedilol,,,,kidney disorder,,,,, +12564717,4557,,prevents,,Carvedilol,,,,atrial fibrillation,,,,, +8686828,4558,,prevents,,Carvedilol,,,,Left ventricular hypertrophy,,,,, +23747042,4559,,predisposes,,Carvedilol,,,,type 2 diabetes mellitus,,,,, +22663350,4560,,predisposes,,Carvedilol,,,,atrial fibrillation,,,,, +21640789,4561,,predisposes,,Carvedilol,,,,hypoglycemia,,,,, +21331523,4562,,predisposes,,Carvedilol,,,,myocardial infarction,,,,, +20291576,4563,,related to,,Raloxifene,,,,schizophrenia,,,,, +13558027,4564,,related to,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +27583128,4565,,causes,,Raloxifene,,,,breast neoplasm,,,,, +20242808,4566,,affects,,Raloxifene,,,,psychotic disorder,,,,, +16098538,4567,,affects,,Raloxifene,,,,schizophrenia,,,,, +15267794,4568,,affects,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, +11233936,4569,,affects,,Raloxifene,,,,breast neoplasm,,,,, +10869334,4570,,affects,,Raloxifene,,,,osteoporosis,,,,, +9569313,4571,,affects,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +15267792,4572,,disrupts,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, +13369623,4573,,disrupts,,Raloxifene,,,,osteoporosis,,,,, +7874352,4574,,disrupts,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +16984197,4575,,prevents,,Raloxifene,,,,Alzheimer disease,,,,, +12036378,4576,,prevents,,Raloxifene,,,,breast neoplasm,,,,, +7813032,4577,,prevents,,Raloxifene,,,,postmenopausal osteoporosis,,,,, +7578651,4578,,prevents,,Raloxifene,,,,osteoporosis,,,,, +7570810,4579,,prevents,,Raloxifene,,,,Marchiafava-Bignami disease,,,,, +11746046,4580,,predisposes,,Raloxifene,,,,Alzheimer disease,,,,, +11350173,4581,,predisposes,,Raloxifene,,,,osteoporosis,,,,, +23481448,4582,,prevents,,Bazedoxifene acetate,,,,osteoporosis,,,,, +19905553,4583,,disrupts,,Ospemifene,,,,psychologic dyspareunia,,,,, +15516940,4584,,affects,,Sufentanil,,,,Pain,,,,, +20743116,4585,,prevents,,Sufentanil,,,,delirium,,,,, +8151024,4586,,prevents,,Sufentanil,,,,Pain,,,,, +12819365,4587,,related to,,Streptomycin,,,,Buruli ulcer disease,,,,, +11425591,4588,,related to,,Streptomycin,,,,osteomyelitis,,,,, +10417352,4589,,related to,,Streptomycin,,,,plague,,,,, +10748245,4590,,causes,,Streptomycin,,,,plague,,,,, +26655494,4591,,prevents,,Streptomycin,,,,mycobacterium avium complex disease,,,,, +14226518,4592,,related to,,Paromomycin,,,,cutaneous leishmaniasis,,,,, +12550860,4593,,related to,,Paromomycin,,,,visceral leishmaniasis,,,,, +24692385,4594,,affects,,Paromomycin,,,,leishmaniasis,,,,, +23700620,4595,,affects,,Paromomycin,,,,visceral leishmaniasis,,,,, +22567030,4596,,affects,,Paromomycin,,,,cutaneous leishmaniasis,,,,, +27729096,4597,,related to,,Kanamycin,,,,bacterial infectious disease,,,,, +10553348,4598,,related to,,Kanamycin,,,,tuberculosis,,,,, +10567002,4599,,affects,,Kanamycin,,,,tuberculosis,,,,, +25418796,4600,,related to,,Vancomycin,,,,ulcerative colitis,,,,, +24528866,4601,,related to,,Vancomycin,,,,bacterial infectious disease,,,,, +23989025,4602,,related to,,Vancomycin,,,,Inflammation,,,,, +22667296,4603,,related to,,Vancomycin,,,,arthropathy,,,,, +21740759,4604,,related to,,Vancomycin,,,,Infection,,,,, +20543239,4605,,related to,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, +20099844,4606,,related to,,Vancomycin,,,,cystic fibrosis,,,,, +18717834,4607,,related to,,Vancomycin,,,,eye infectious disorder,,,,, +18563763,4608,,related to,,Vancomycin,,,,staphylococcal pneumonia,,,,, +17578296,4609,,related to,,Vancomycin,,,,Peptidoglycan,,,,, +17578296,4610,,related to,,Vancomycin,,,,Peptidoglycan,,,,, +15843803,4611,,related to,,Vancomycin,,,,Diabetic Foot,,,,, +15502624,4612,,related to,,Vancomycin,,,,abscess,,,,, +15448370,4613,,related to,,Vancomycin,,,,obesity disorder,,,,, +15389679,4614,,related to,,Vancomycin,,,,osteomyelitis,,,,, +15008716,4615,,related to,,Vancomycin,,,,peritonitis,,,,, +14607992,4616,,related to,,Vancomycin,,,,pneumonia,,,,, +14564943,4617,,related to,,Vancomycin,,,,gram-positive bacterial infections,,,,, +11348824,4618,,related to,,Vancomycin,,,,kidney failure,,,,, +11195361,4619,,related to,,Vancomycin,,,,Neonatal sepsis,,,,, +10946982,4620,,related to,,Vancomycin,,,,respiratory tract infectious disorder,,,,, +10225522,4621,,related to,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, +9057886,4622,,related to,,Vancomycin,,,,nosocomial infection,,,,, +9057885,4623,,related to,,Vancomycin,,,,staphylococcal infection,,,,, +8859000,4624,,related to,,Vancomycin,,,,endocarditis,,,,, +8170422,4625,,related to,,Vancomycin,,,,Sepsis,,,,, +23445509,4626,,related to,,Vancomycin,,,,peritonitis,,,,, +22719539,4627,,related to,,Vancomycin,,,,Infection,,,,, +11098147,4628,,related to,,Vancomycin,,,,Inflammation,,,,, +14094746,4629,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, +14094746,4630,,coexists with,,Vancomycin,,,,Peptidoglycan,,,,, +7840667,4631,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, +7710804,4632,,physically interacts with,,Vancomycin,,,,Peptidoglycan,,,,, +26896148,4633,,causes,,Vancomycin,,,,endocarditis,,,,, +26320414,4634,,causes,,Vancomycin,,,,enterocolitis,,,,, +22849619,4635,,causes,,Vancomycin,,,,Infection,,,,, +22231760,4636,,causes,,Vancomycin,,,,Inflammation,,,,, +21632936,4637,,causes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, +18945219,4638,,causes,,Vancomycin,,,,peritonitis,,,,, +15481792,4639,,causes,,Vancomycin,,,,skin disorder,,,,, +12001625,4640,,causes,,Vancomycin,,,,kidney failure,,,,, +9570250,4641,,causes,,Vancomycin,,,,nosocomial infection,,,,, +23893373,4642,,affects,,Vancomycin,,,,Infection,,,,, +21581118,4643,,affects,,Vancomycin,,,,Infection,,,,, +21291384,4644,,affects,,Vancomycin,,,,hematopoietic and lymphoid system neoplasm,,,,, +20283933,4645,,affects,,Vancomycin,,,,enterocolitis,,,,, +19879029,4646,,affects,,Vancomycin,,,,cystic fibrosis,,,,, +16899271,4647,,affects,,Vancomycin,,,,Sepsis,,,,, +15270589,4648,,affects,,Vancomycin,,,,peritonitis,,,,, +13735180,4649,,affects,,Vancomycin,,,,pneumonia,,,,, +12348278,4650,,affects,,Vancomycin,,,,Sepsis,,,,, +12348277,4651,,affects,,Vancomycin,,,,osteomyelitis,,,,, +12348276,4652,,affects,,Vancomycin,,,,endocarditis,,,,, +7991855,4653,,affects,,Vancomycin,,,,Peptidoglycan,,,,, +7527991,4654,,affects,,Vancomycin,,,,pneumonia,,,,, +17707788,4655,,affects,,Vancomycin,,,,Peptidoglycan,,,,, +22719533,4656,,disrupts,,Vancomycin,,,,Infection,,,,, +21036263,4657,,disrupts,,Vancomycin,,,,osteomyelitis,,,,, +19924841,4658,,disrupts,,Vancomycin,,,,Inflammation,,,,, +14538194,4659,,disrupts,,Vancomycin,,,,enterocolitis,,,,, +21888394,4660,,prevents,,Vancomycin,,,,bacterial infectious disease,,,,, +21518539,4661,,prevents,,Vancomycin,,,,Infection,,,,, +21292683,4662,,prevents,,Vancomycin,,,,osteomyelitis,,,,, +20759704,4663,,prevents,,Vancomycin,,,,kidney failure,,,,, +20759520,4664,,prevents,,Vancomycin,,,,arthropathy,,,,, +16424860,4665,,prevents,,Vancomycin,,,,pneumonia,,,,, +11136130,4666,,prevents,,Vancomycin,,,,nosocomial infection,,,,, +8520533,4667,,prevents,,Vancomycin,,,,peritonitis,,,,, +8203212,4668,,prevents,,Vancomycin,,,,endocarditis,,,,, +8170423,4669,,prevents,,Vancomycin,,,,Neonatal sepsis,,,,, +8170420,4670,,prevents,,Vancomycin,,,,Sepsis,,,,, +7111089,4671,,prevents,,Vancomycin,,,,Inflammation,,,,, +25178384,4672,,exacerbates,,Vancomycin,,,,Inflammation,,,,, +21622859,4673,,exacerbates,,Vancomycin,,,,pneumonia,,,,, +21314122,4674,,predisposes,,Vancomycin,,,,Sepsis,,,,, +19879549,4675,,predisposes,,Vancomycin,,,,kidney failure,,,,, +18555479,4676,,predisposes,,Vancomycin,,,,pneumonia,,,,, +18327103,4677,,predisposes,,Vancomycin,,,,nosocomial infection,,,,, +12689487,4678,,predisposes,,Vancomycin,,,,bacterial infectious disease with sepsis,,,,, +12018679,4679,,related to,,LENOGRASTIM,,,,plasma cell myeloma,,,,, +24207855,4680,,related to,,SARGRAMOSTIM,,,,pulmonary alveolar proteinosis,,,,, +23712911,4681,,related to,,SARGRAMOSTIM,,,,Sepsis,,,,, +23712910,4682,,related to,,SARGRAMOSTIM,,,,adult acute respiratory distress syndrome,,,,, +23177848,4683,,related to,,SARGRAMOSTIM,,,,Alzheimer disease,,,,, +16827749,4684,,related to,,SARGRAMOSTIM,,,,prostate cancer,,,,, +11846978,4685,,related to,,SARGRAMOSTIM,,,,Crohn disease,,,,, +7671811,4686,,related to,,SARGRAMOSTIM,,,,HIV infectious disease,,,,, +7896656,4687,,prevents,,SARGRAMOSTIM,,,,neutropenia,,,,, +27611311,4688,,related to,,Filgrastim,,,,sarcoma,,,,, +26602673,4689,,related to,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, +26505391,4690,,related to,,Filgrastim,,,,Hodgkins lymphoma,,,,, +23038064,4691,,related to,,Filgrastim,,,,Infection,,,,, +22749433,4692,,related to,,Filgrastim,,,,neoplasm,,,,, +19713781,4693,,related to,,Filgrastim,,,,lymphoma,,,,, +18903615,4694,,related to,,Filgrastim,,,,HIV infectious disease,,,,, +17402873,4695,,related to,,Filgrastim,,,,acute myeloid leukemia,,,,, +16080456,4696,,related to,,Filgrastim,,,,plasma cell myeloma,,,,, +14467347,4697,,related to,,Filgrastim,,,,myocardial infarction,,,,, +13860825,4698,,related to,,Filgrastim,,,,small cell lung carcinoma,,,,, +10253688,4699,,related to,,Filgrastim,,,,ovarian cancer,,,,, +9334871,4700,,related to,,Filgrastim,,,,non-small cell lung carcinoma,,,,, +7868897,4701,,related to,,Filgrastim,,,,neutropenia,,,,, +7775323,4702,,related to,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, +13176527,4703,,has part,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, +27488127,4704,,causes,,Filgrastim,,,,acute myeloid leukemia,,,,, +26596932,4705,,causes,,Filgrastim,,,,acute lymphoblastic leukemia,,,,, +19245347,4706,,causes,,Filgrastim,,,,myeloproliferative neoplasm,,,,, +8419399,4707,,causes,,Filgrastim,,,,neutropenia,,,,, +26496059,4708,,affects,,Filgrastim,,,,neutropenia,,,,, +15351355,4709,,affects,,Filgrastim,,,,Fever,,,,, +7868413,4710,,affects,,Filgrastim,,,,neutropenia,,,,, +9501874,4711,,disrupts,,Filgrastim,,,,neutropenia,,,,, +14309803,4712,,prevents,,Filgrastim,,,,non-Hodgkin lymphoma,,,,, +7265196,4713,,prevents,,Filgrastim,,,,neutropenia,,,,, +16134815,4714,,predisposes,,Filgrastim,,,,hematopoietic and lymphoid system neoplasm,,,,, +14495646,4715,,predisposes,,Filgrastim,,,,neutropenia,,,,, +12306052,4716,,affects,,Tibolone,,,,physiological sexual disorder,,,,, +7873396,4717,,prevents,,Tibolone,,,,osteoporosis,,,,, +17565484,4718,,affects,,Cosyntropin,,,,West syndrome,,,,, +11757081,4719,,disrupts,,Cosyntropin,,,,hypertensive disorder,,,,, +19585114,4720,,related to,,Corticotropin,,,,chronic progressive multiple sclerosis,,,,, +15839924,4721,,related to,,Corticotropin,,,,membranous glomerulonephritis,,,,, +10947313,4722,,related to,,Corticotropin,,,,polycystic ovary syndrome,,,,, +10518316,4723,,related to,,Corticotropin,,,,dermatomyositis,,,,, +10489579,4724,,related to,,Corticotropin,,,,epilepsy,,,,, +10438408,4725,,related to,,Corticotropin,,,,nephrotic syndrome,,,,, +10431205,4726,,related to,,Corticotropin,,,,sarcoidosis,,,,, +10427009,4727,,related to,,Corticotropin,,,,optic neuritis,,,,, +9718321,4728,,related to,,Corticotropin,,,,rheumatoid arthritis,,,,, +8496620,4729,,related to,,Corticotropin,,,,multiple sclerosis,,,,, +7394246,4730,,related to,,Corticotropin,,,,West syndrome,,,,, +22849896,4731,,causes,,Corticotropin,,,,West syndrome,,,,, +12436107,4732,,causes,,Corticotropin,,,,epilepsy,,,,, +11010111,4733,,causes,,Corticotropin,,,,rheumatoid arthritis,,,,, +17565428,4734,,affects,,Corticotropin,,,,West syndrome,,,,, +15783986,4735,,affects,,Corticotropin,,,,multiple sclerosis,,,,, +15695412,4736,,affects,,Corticotropin,,,,polycystic ovary syndrome,,,,, +11427275,4737,,affects,,Corticotropin,,,,dermatomyositis,,,,, +10737513,4738,,affects,,Corticotropin,,,,sarcoidosis,,,,, +10422766,4739,,affects,,Corticotropin,,,,rheumatoid arthritis,,,,, +9312832,4740,,affects,,Corticotropin,,,,epilepsy,,,,, +15159690,4741,,disrupts,,Corticotropin,,,,epilepsy,,,,, +27033387,4742,,prevents,,Corticotropin,,,,West syndrome,,,,, +10517176,4743,,prevents,,Corticotropin,,,,epilepsy,,,,, +23224982,4744,,predisposes,,Corticotropin,,,,epilepsy,,,,, +15800284,4745,,related to,,Dabigatran etexilate,,,,atrial fibrillation,,,,, +16972150,4746,,affects,,Dabigatran etexilate,,,,stroke disorder,,,,, +21262475,4747,,prevents,,Dabigatran etexilate,,,,thrombophilia due to thrombin defect,,,,, +19084221,4748,,prevents,,Dabigatran etexilate,,,,thrombotic disease,,,,, +14524874,4749,,prevents,,Dabigatran etexilate,,,,stroke disorder,,,,, +11599698,4750,,prevents,,Dabigatran etexilate,,,,Thromboembolism,,,,, +15929248,4751,,predisposes,,Dabigatran etexilate,,,,stroke disorder,,,,, +13343476,4752,,predisposes,,Dabigatran etexilate,,,,Thromboembolism,,,,, +10867084,4753,,related to,,Ximelagatran,,,,atrial fibrillation,,,,, +12162541,4754,,prevents,,Ximelagatran,,,,thrombotic disease,,,,, +9396435,4755,,prevents,,Ximelagatran,,,,Thromboembolism,,,,, +13148663,4756,,predisposes,,Ximelagatran,,,,Thromboembolism,,,,, +24220155,4757,,related to,,Bivalirudin,,,,Hemorrhage,,,,, +23845334,4758,,related to,,Bivalirudin,,,,thrombocytopenia,,,,, +21128552,4759,,related to,,Bivalirudin,,,,heart disorder,,,,, +16166302,4760,,related to,,Bivalirudin,,,,coronary artery disorder,,,,, +9469606,4761,,related to,,Bivalirudin,,,,myocardial infarction,,,,, +9060136,4762,,related to,,Bivalirudin,,,,acute coronary syndrome,,,,, +21743704,4763,,related to,,Bivalirudin,,,,Hemorrhage,,,,, +18003165,4764,,related to,,Bivalirudin,,,,thrombotic disease,,,,, +15575490,4765,,causes,,Bivalirudin,,,,myocardial infarction,,,,, +10298579,4766,,causes,,Bivalirudin,,,,Hemorrhage,,,,, +19056194,4767,,affects,,Bivalirudin,,,,thrombotic disease,,,,, +15575489,4768,,affects,,Bivalirudin,,,,thrombotic disease,,,,, +14748514,4769,,affects,,Bivalirudin,,,,myocardial infarction,,,,, +14318099,4770,,affects,,Bivalirudin,,,,Hemorrhage,,,,, +9597163,4771,,affects,,Bivalirudin,,,,Hemorrhage,,,,, +19316921,4772,,disrupts,,Bivalirudin,,,,myocardial infarction,,,,, +19056195,4773,,disrupts,,Bivalirudin,,,,thrombotic disease,,,,, +13525067,4774,,disrupts,,Bivalirudin,,,,acute coronary syndrome,,,,, +13434992,4775,,disrupts,,Bivalirudin,,,,Hemorrhage,,,,, +21793150,4776,,prevents,,Bivalirudin,,,,Hemorrhage,,,,, +20637086,4777,,prevents,,Bivalirudin,,,,syndromic disease,,,,, +17823880,4778,,prevents,,Bivalirudin,,,,myocardial infarction,,,,, +10215156,4779,,prevents,,Bivalirudin,,,,thrombotic disease,,,,, +22425248,4780,,predisposes,,Bivalirudin,,,,Hemorrhage,,,,, +16276306,4781,,predisposes,,Bivalirudin,,,,thrombotic disease,,,,, +14172527,4782,,predisposes,,Bivalirudin,,,,myocardial infarction,,,,, +17086386,4783,,disrupts,,Melagatran,,,,thrombotic disease,,,,, +9182682,4784,,related to,,Lepirudin,,,,thrombotic disease,,,,, +27183131,4785,,affects,,Lepirudin,,,,thrombotic disease,,,,, +26612130,4786,,disrupts,,Lepirudin,,,,thrombotic disease,,,,, +9038512,4787,,prevents,,Lepirudin,,,,thrombotic disease,,,,, +24074121,4788,,affects,,Ripasudil,,,,Fuchs' endothelial dystrophy,,,,, +23144840,4789,,prevents,,Netarsudil,,,,corneal edema,,,,, +21457868,4790,,prevents,,Netarsudil,,,,open-angle glaucoma,,,,, +25249408,4791,,related to,,Calcitriol,,,,Hypocalcemia,,,,, +24424216,4792,,related to,,Calcitriol,,,,Crohn disease,,,,, +23057137,4793,,related to,,Calcitriol,,,,acute kidney failure,,,,, +21048179,4794,,related to,,Calcitriol,,,,breast neoplasm,,,,, +18873537,4795,,related to,,Calcitriol,,,,diabetic kidney disease,,,,, +17759117,4796,,related to,,Calcitriol,,,,Sepsis,,,,, +17014883,4797,,related to,,Calcitriol,,,,hypoparathyroidism,,,,, +16783681,4798,,related to,,Calcitriol,,,,non-small cell lung carcinoma,,,,, +16670490,4799,,related to,,Calcitriol,,,,postmenopausal osteoporosis,,,,, +16084679,4800,,related to,,Calcitriol,,,,hypertensive disorder,,,,, +15183062,4801,,related to,,Calcitriol,,,,type 1 diabetes mellitus,,,,, +13574949,4802,,related to,,Calcitriol,,,,neoplasm,,,,, +13228040,4803,,related to,,Calcitriol,,,,castration-resistant prostate carcinoma,,,,, +11632117,4804,,related to,,Calcitriol,,,,prostate cancer,,,,, +11549262,4805,,related to,,Calcitriol,,,,renal osteodystrophy,,,,, +11138207,4806,,related to,,Calcitriol,,,,skin basal cell carcinoma,,,,, +9056874,4807,,related to,,Calcitriol,,,,psoriasis,,,,, +8335532,4808,,related to,,Calcitriol,,,,chronic kidney disease,,,,, +7638906,4809,,related to,,Calcitriol,,,,myelodysplastic syndrome,,,,, +7210521,4810,,related to,,Calcitriol,,,,osteoporosis,,,,, +23300761,4811,,causes,,Calcitriol,,,,hypoparathyroidism,,,,, +22190855,4812,,causes,,Calcitriol,,,,Hypocalcemia,,,,, +13672029,4813,,causes,,Calcitriol,,,,renal osteodystrophy,,,,, +8610431,4814,,causes,,Calcitriol,,,,neoplasm,,,,, +26699785,4815,,affects,,Calcitriol,,,,myelodysplastic syndrome,,,,, +26649101,4816,,affects,,Calcitriol,,,,psoriasis,,,,, +20118335,4817,,affects,,Calcitriol,,,,chronic kidney disease,,,,, +18144364,4818,,affects,,Calcitriol,,,,diabetic kidney disease,,,,, +17907580,4819,,affects,,Calcitriol,,,,breast neoplasm,,,,, +15840384,4820,,affects,,Calcitriol,,,,skin basal cell carcinoma,,,,, +15206874,4821,,affects,,Calcitriol,,,,neoplasm,,,,, +15145405,4822,,affects,,Calcitriol,,,,neoplasm,,,,, +10932246,4823,,affects,,Calcitriol,,,,chronic kidney disease,,,,, +9912093,4824,,affects,,Calcitriol,,,,prostate cancer,,,,, +9912091,4825,,affects,,Calcitriol,,,,prostate cancer,,,,, +26695789,4826,,produces,,Calcitriol,,,,renal osteodystrophy,,,,, +14288417,4827,,produces,,Calcitriol,,,,Crohn disease,,,,, +19013737,4828,,disrupts,,Calcitriol,,,,chronic kidney disease,,,,, +17492128,4829,,disrupts,,Calcitriol,,,,prostate cancer,,,,, +15711853,4830,,disrupts,,Calcitriol,,,,neoplasm,,,,, +23005720,4831,,prevents,,Calcitriol,,,,neoplasm,,,,, +22688863,4832,,prevents,,Calcitriol,,,,Hypocalcemia,,,,, +18398383,4833,,prevents,,Calcitriol,,,,diabetic kidney disease,,,,, +17492127,4834,,prevents,,Calcitriol,,,,prostate cancer,,,,, +8346486,4835,,prevents,,Calcitriol,,,,osteoporosis,,,,, +8053720,4836,,prevents,,Calcitriol,,,,postmenopausal osteoporosis,,,,, +24886178,4837,,exacerbates,,Calcitriol,,,,Sepsis,,,,, +18653087,4838,,exacerbates,,Calcitriol,,,,hypertensive disorder,,,,, +21373396,4839,,predisposes,,Calcitriol,,,,chronic kidney disease,,,,, +17377804,4840,,predisposes,,Calcitriol,,,,hypertensive disorder,,,,, +16828204,4841,,predisposes,,Calcitriol,,,,osteoporosis,,,,, +9760670,4842,,predisposes,,Calcitriol,,,,prostate cancer,,,,, +26462827,4843,,related to,,Alfacalcidol,,,,kidney failure,,,,, +9037270,4844,,related to,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, +7210524,4845,,related to,,Alfacalcidol,,,,osteoporosis,,,,, +22711685,4846,,causes,,Alfacalcidol,,,,osteoporosis,,,,, +26635675,4847,,affects,,Alfacalcidol,,,,kidney failure,,,,, +21927698,4848,,affects,,Alfacalcidol,,,,myopathy,,,,, +11900508,4849,,affects,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, +8505855,4850,,affects,,Alfacalcidol,,,,osteoporosis,,,,, +20641062,4851,,disrupts,,Alfacalcidol,,,,osteoporosis,,,,, +21927699,4852,,prevents,,Alfacalcidol,,,,myopathy,,,,, +7684744,4853,,prevents,,Alfacalcidol,,,,osteoporosis,,,,, +7684734,4854,,prevents,,Alfacalcidol,,,,postmenopausal osteoporosis,,,,, +24020567,4855,,related to,,Cholecalciferol,,,,male infertility,,,,, +23185349,4856,,related to,,Cholecalciferol,,,,ulcerative colitis,,,,, +22584995,4857,,related to,,Cholecalciferol,,,,acute myeloid leukemia,,,,, +21514930,4858,,related to,,Cholecalciferol,,,,Infection,,,,, +21254434,4859,,related to,,Cholecalciferol,,,,depressive disorder,,,,, +20389616,4860,,related to,,Cholecalciferol,,,,anemia,,,,, +20190699,4861,,related to,,Cholecalciferol,,,,autism spectrum disorder,,,,, +19639056,4862,,related to,,Cholecalciferol,,,,pulmonary tuberculosis,,,,, +18980881,4863,,related to,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, +18889413,4864,,related to,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, +18830431,4865,,related to,,Cholecalciferol,,,,prostate cancer,,,,, +18776998,4866,,related to,,Cholecalciferol,,,,epilepsy,,,,, +18009382,4867,,related to,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, +17581366,4868,,related to,,Cholecalciferol,,,,vitamin D deficiency,,,,, +17374616,4869,,related to,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, +17169513,4870,,related to,,Cholecalciferol,,,,Parkinson disease,,,,, +17054911,4871,,related to,,Cholecalciferol,,,,tuberculosis,,,,, +16909919,4872,,related to,,Cholecalciferol,,,,inflammatory bowel disease,,,,, +16219443,4873,,related to,,Cholecalciferol,,,,"dermatitis, atopic",,,,, +16115730,4874,,related to,,Cholecalciferol,,,,cardiovascular disorder,,,,, +15133291,4875,,related to,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +14512631,4876,,related to,,Cholecalciferol,,,,hyperparathyroidism,,,,, +13680137,4877,,related to,,Cholecalciferol,,,,multiple sclerosis,,,,, +13562951,4878,,related to,,Cholecalciferol,,,,metabolic syndrome X,,,,, +13562949,4879,,related to,,Cholecalciferol,,,,obesity disorder,,,,, +13035326,4880,,related to,,Cholecalciferol,,,,bone fracture,,,,, +11935565,4881,,related to,,Cholecalciferol,,,,osteoporosis,,,,, +11152529,4882,,related to,,Cholecalciferol,,,,diabetes mellitus,,,,, +10386853,4883,,related to,,Cholecalciferol,,,,Crohn disease,,,,, +9703967,4884,,related to,,Cholecalciferol,,,,melanoma,,,,, +9414232,4885,,related to,,Cholecalciferol,,,,psoriasis,,,,, +8798994,4886,,related to,,Cholecalciferol,,,,hip fracture,,,,, +20878953,4887,,causes,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, +20469671,4888,,causes,,Cholecalciferol,,,,tuberculosis,,,,, +20417553,4889,,causes,,Cholecalciferol,,,,psoriasis,,,,, +19411734,4890,,causes,,Cholecalciferol,,,,"dermatitis, atopic",,,,, +17854537,4891,,causes,,Cholecalciferol,,,,neoplasm,,,,, +15944158,4892,,causes,,Cholecalciferol,,,,vitamin D deficiency,,,,, +13998286,4893,,causes,,Cholecalciferol,,,,depressive disorder,,,,, +27560876,4894,,affects,,Cholecalciferol,,,,prostate cancer,,,,, +22640117,4895,,affects,,Cholecalciferol,,,,severe acute respiratory syndrome,,,,, +21843529,4896,,affects,,Cholecalciferol,,,,Pregnancy,,,,, +21703950,4897,,affects,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +20945952,4898,,affects,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, +20733345,4899,,affects,,Cholecalciferol,,,,epilepsy,,,,, +20612106,4900,,affects,,Cholecalciferol,,,,Cognitive impairment,,,,, +19925618,4901,,affects,,Cholecalciferol,,,,asthma,,,,, +19815601,4902,,affects,,Cholecalciferol,,,,ulcerative colitis,,,,, +19556148,4903,,affects,,Cholecalciferol,,,,neoplasm,,,,, +19132727,4904,,affects,,Cholecalciferol,,,,obesity disorder,,,,, +18122364,4905,,affects,,Cholecalciferol,,,,metabolic syndrome X,,,,, +18122363,4906,,affects,,Cholecalciferol,,,,cardiovascular disorder,,,,, +17715748,4907,,affects,,Cholecalciferol,,,,hip fracture,,,,, +17674517,4908,,affects,,Cholecalciferol,,,,Pregnancy,,,,, +17585577,4909,,affects,,Cholecalciferol,,,,depressive disorder,,,,, +17451551,4910,,affects,,Cholecalciferol,,,,neoplasm,,,,, +16299943,4911,,affects,,Cholecalciferol,,,,polycystic ovary syndrome,,,,, +16007821,4912,,affects,,Cholecalciferol,,,,psoriasis,,,,, +15977971,4913,,affects,,Cholecalciferol,,,,melanoma,,,,, +15944152,4914,,affects,,Cholecalciferol,,,,osteoporosis,,,,, +15393278,4915,,affects,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, +15170889,4916,,affects,,Cholecalciferol,,,,multiple sclerosis,,,,, +13518388,4917,,affects,,Cholecalciferol,,,,bone fracture,,,,, +21045274,4918,,produces,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +17840044,4919,,produces,,Cholecalciferol,,,,inflammatory bowel disease,,,,, +20733344,4920,,disrupts,,Cholecalciferol,,,,epilepsy,,,,, +19044664,4921,,disrupts,,Cholecalciferol,,,,AIDS,,,,, +15558469,4922,,disrupts,,Cholecalciferol,,,,HIV infectious disease,,,,, +14834931,4923,,disrupts,,Cholecalciferol,,,,neoplasm,,,,, +14617748,4924,,disrupts,,Cholecalciferol,,,,multiple sclerosis,,,,, +14491908,4925,,disrupts,,Cholecalciferol,,,,vitamin D deficiency,,,,, +11194374,4926,,disrupts,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +25419746,4927,,prevents,,Cholecalciferol,,,,Infection,,,,, +23552226,4928,,prevents,,Cholecalciferol,,,,type 1 diabetes mellitus,,,,, +23324302,4929,,prevents,,Cholecalciferol,,,,ulcerative colitis,,,,, +22418643,4930,,prevents,,Cholecalciferol,,,,chronic obstructive pulmonary disease,,,,, +22340834,4931,,prevents,,Cholecalciferol,,,,depressive disorder,,,,, +20959064,4932,,prevents,,Cholecalciferol,,,,postmenopausal osteoporosis,,,,, +20699168,4933,,prevents,,Cholecalciferol,,,,cardiovascular disorder,,,,, +19389521,4934,,prevents,,Cholecalciferol,,,,epilepsy,,,,, +18282049,4935,,prevents,,Cholecalciferol,,,,inherited lipid metabolism disorder,,,,, +17951280,4936,,prevents,,Cholecalciferol,,,,anemia,,,,, +17701830,4937,,prevents,,Cholecalciferol,,,,influenza,,,,, +15773595,4938,,prevents,,Cholecalciferol,,,,neoplasm,,,,, +15663430,4939,,prevents,,Cholecalciferol,,,,diabetes mellitus,,,,, +12943427,4940,,prevents,,Cholecalciferol,,,,vitamin D deficiency,,,,, +11194373,4941,,prevents,,Cholecalciferol,,,,osteoporosis,,,,, +11017561,4942,,prevents,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +10503621,4943,,prevents,,Cholecalciferol,,,,bone fracture,,,,, +9458588,4944,,prevents,,Cholecalciferol,,,,hip fracture,,,,, +21072124,4945,,predisposes,,Cholecalciferol,,,,metabolic syndrome X,,,,, +18104348,4946,,predisposes,,Cholecalciferol,,,,colorectal neoplasm,,,,, +17901013,4947,,predisposes,,Cholecalciferol,,,,bone fracture,,,,, +17714481,4948,,predisposes,,Cholecalciferol,,,,asthma,,,,, +17184810,4949,,predisposes,,Cholecalciferol,,,,multiple sclerosis,,,,, +15110409,4950,,predisposes,,Cholecalciferol,,,,vitamin D deficiency,,,,, +13562954,4951,,predisposes,,Cholecalciferol,,,,type 2 diabetes mellitus,,,,, +9524358,4952,,predisposes,,Cholecalciferol,,,,hip fracture,,,,, +9314384,4953,,predisposes,,Cholecalciferol,,,,Marchiafava-Bignami disease,,,,, +27330803,4954,,related to,,Ergocalciferol,,,,Familial hypophosphatemia,,,,, +26089502,4955,,related to,,Ergocalciferol,,,,osteogenesis imperfecta,,,,, +22199149,4956,,related to,,Ergocalciferol,,,,Hypocalcemia,,,,, +22194600,4957,,related to,,Ergocalciferol,,,,severe acute respiratory syndrome,,,,, +21840711,4958,,related to,,Ergocalciferol,,,,castration-resistant prostate carcinoma,,,,, +21543726,4959,,related to,,Ergocalciferol,,,,sarcopenia,,,,, +21516783,4960,,related to,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, +21478252,4961,,related to,,Ergocalciferol,,,,bone fracture,,,,, +21128214,4962,,related to,,Ergocalciferol,,,,bone Paget disease,,,,, +20256197,4963,,related to,,Ergocalciferol,,,,restless legs syndrome,,,,, +19853448,4964,,related to,,Ergocalciferol,,,,neuralgia,,,,, +19595978,4965,,related to,,Ergocalciferol,,,,hepatitis C virus infection,,,,, +19221334,4966,,related to,,Ergocalciferol,,,,spinal cord injury,,,,, +18303138,4967,,related to,,Ergocalciferol,,,,optic neuritis,,,,, +17457750,4968,,related to,,Ergocalciferol,,,,migraine disorder,,,,, +17248671,4969,,related to,,Ergocalciferol,,,,diffuse alopecia areata,,,,, +16231683,4970,,related to,,Ergocalciferol,,,,chronic hepatitis C virus infection,,,,, +16050991,4971,,related to,,Ergocalciferol,,,,lung neoplasm,,,,, +15954794,4972,,related to,,Ergocalciferol,,,,femoral neck fracture,,,,, +15739454,4973,,related to,,Ergocalciferol,,,,diabetic neuropathy,,,,, +15603622,4974,,related to,,Ergocalciferol,,,,HIV infectious disease,,,,, +15306422,4975,,related to,,Ergocalciferol,,,,blood coagulation disease,,,,, +15165807,4976,,related to,,Ergocalciferol,,,,postmenopausal osteoporosis,,,,, +14949967,4977,,related to,,Ergocalciferol,,,,Premature birth,,,,, +14949966,4978,,related to,,Ergocalciferol,,,,gestational diabetes,,,,, +14870236,4979,,related to,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, +14594285,4980,,related to,,Ergocalciferol,,,,colorectal neoplasm,,,,, +14321159,4981,,related to,,Ergocalciferol,,,,asthma,,,,, +13975664,4982,,related to,,Ergocalciferol,,,,cutaneous lupus erythematosus,,,,, +13939480,4983,,related to,,Ergocalciferol,,,,mood disorder,,,,, +13895667,4984,,related to,,Ergocalciferol,,,,sudden cardiac arrest,,,,, +13383363,4985,,related to,,Ergocalciferol,,,,sickle cell anemia,,,,, +13199782,4986,,related to,,Ergocalciferol,,,,Alzheimer disease,,,,, +12834035,4987,,related to,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +12803681,4988,,related to,,Ergocalciferol,,,,Insulin resistance,,,,, +12377378,4989,,related to,,Ergocalciferol,,,,non-Hodgkin lymphoma,,,,, +12131992,4990,,related to,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +11979233,4991,,related to,,Ergocalciferol,,,,leukemia,,,,, +11933002,4992,,related to,,Ergocalciferol,,,,Pain,,,,, +11653558,4993,,related to,,Ergocalciferol,,,,melanoma,,,,, +11434397,4994,,related to,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +11002964,4995,,related to,,Ergocalciferol,,,,pulmonary tuberculosis,,,,, +10894479,4996,,related to,,Ergocalciferol,,,,Crohn disease,,,,, +10768947,4997,,related to,,Ergocalciferol,,,,hip fracture,,,,, +10183383,4998,,related to,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +10168534,4999,,related to,,Ergocalciferol,,,,tuberculosis,,,,, +10066878,5000,,related to,,Ergocalciferol,,,,lymphoma,,,,, +9770434,1,,related to,,Ergocalciferol,,,,neoplasm,,,,, +9499640,2,,related to,,Ergocalciferol,,,,hypoparathyroidism,,,,, +9487308,3,,related to,,Ergocalciferol,,,,myocardial ischemia,,,,, +9462983,4,,related to,,Ergocalciferol,,,,ulcerative colitis,,,,, +9176947,5,,related to,,Ergocalciferol,,,,psoriasis,,,,, +9137351,6,,related to,,Ergocalciferol,,,,nutritional disorder,,,,, +8792180,7,,related to,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +8116213,8,,related to,,Ergocalciferol,,,,obesity disorder,,,,, +8093753,9,,related to,,Ergocalciferol,,,,vitamin D deficiency,,,,, +8061037,10,,related to,,Ergocalciferol,,,,multiple sclerosis,,,,, +8061036,11,,related to,,Ergocalciferol,,,,diabetes mellitus,,,,, +7613246,12,,related to,,Ergocalciferol,,,,osteoporosis,,,,, +7587226,13,,related to,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, +7252642,14,,related to,,Ergocalciferol,,,,prostate cancer,,,,, +26403196,15,,causes,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +25624374,16,,causes,,Ergocalciferol,,,,leukemia,,,,, +25513025,17,,causes,,Ergocalciferol,,,,restless legs syndrome,,,,, +25147512,18,,causes,,Ergocalciferol,,,,sarcopenia,,,,, +21420546,19,,causes,,Ergocalciferol,,,,diabetic neuropathy,,,,, +21344725,20,,causes,,Ergocalciferol,,,,diffuse alopecia areata,,,,, +19221130,21,,causes,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, +19022139,22,,causes,,Ergocalciferol,,,,gestational diabetes,,,,, +18967408,23,,causes,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, +18875338,24,,causes,,Ergocalciferol,,,,psoriasis,,,,, +18041148,25,,causes,,Ergocalciferol,,,,Crohn disease,,,,, +16369420,26,,causes,,Ergocalciferol,,,,neoplasm,,,,, +16017645,27,,causes,,Ergocalciferol,,,,obesity disorder,,,,, +15862130,28,,causes,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +15179909,29,,causes,,Ergocalciferol,,,,asthma,,,,, +14594790,30,,causes,,Ergocalciferol,,,,Insulin resistance,,,,, +14004176,31,,causes,,Ergocalciferol,,,,Pain,,,,, +12191251,32,,causes,,Ergocalciferol,,,,osteoporosis,,,,, +11612180,33,,causes,,Ergocalciferol,,,,colorectal neoplasm,,,,, +11557471,34,,causes,,Ergocalciferol,,,,vitamin D deficiency,,,,, +11557464,35,,causes,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +11275618,36,,causes,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +10362733,37,,causes,,Ergocalciferol,,,,multiple sclerosis,,,,, +8719466,38,,causes,,Ergocalciferol,,,,diabetes mellitus,,,,, +8407906,39,,causes,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +7553325,40,,causes,,Ergocalciferol,,,,prostate cancer,,,,, +7357695,41,,causes,,Ergocalciferol,,,,bone fracture,,,,, +25936029,42,,affects,,Ergocalciferol,,,,nutritional disorder,,,,, +25430100,43,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +24682916,44,,affects,,Ergocalciferol,,,,bone fracture,,,,, +24133915,45,,affects,,Ergocalciferol,,,,HIV infectious disease,,,,, +23716846,46,,affects,,Ergocalciferol,,,,Premature birth,,,,, +22436428,47,,affects,,Ergocalciferol,,,,obesity disorder,,,,, +22382447,48,,affects,,Ergocalciferol,,,,Pregnancy,,,,, +21132793,49,,affects,,Ergocalciferol,,,,breast neoplasm,,,,, +20959246,50,,affects,,Ergocalciferol,,,,diabetes mellitus,,,,, +20298561,51,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +20058982,52,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, +19907316,53,,affects,,Ergocalciferol,,,,gestational diabetes,,,,, +19815602,54,,affects,,Ergocalciferol,,,,ulcerative colitis,,,,, +19320344,55,,affects,,Ergocalciferol,,,,Premature birth,,,,, +19221129,56,,affects,,Ergocalciferol,,,,non-alcoholic fatty liver disease,,,,, +18424308,57,,affects,,Ergocalciferol,,,,vitamin D deficiency,,,,, +18115621,58,,affects,,Ergocalciferol,,,,asthma,,,,, +17654393,59,,affects,,Ergocalciferol,,,,optic neuritis,,,,, +17646826,60,,affects,,Ergocalciferol,,,,migraine disorder,,,,, +17581908,61,,affects,,Ergocalciferol,,,,Pain,,,,, +17056932,62,,affects,,Ergocalciferol,,,,sarcopenia,,,,, +16630786,63,,affects,,Ergocalciferol,,,,sarcopenia,,,,, +16542255,64,,affects,,Ergocalciferol,,,,melanoma,,,,, +16343274,65,,affects,,Ergocalciferol,,,,restless legs syndrome,,,,, +16273798,66,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, +16273796,67,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +15812657,68,,affects,,Ergocalciferol,,,,prostate cancer,,,,, +15750325,69,,affects,,Ergocalciferol,,,,polycystic ovary syndrome,,,,, +15694248,70,,affects,,Ergocalciferol,,,,mood disorder,,,,, +15543952,71,,affects,,Ergocalciferol,,,,osteoporosis,,,,, +15528071,72,,affects,,Ergocalciferol,,,,Alzheimer disease,,,,, +15258155,73,,affects,,Ergocalciferol,,,,obesity disorder,,,,, +14609756,74,,affects,,Ergocalciferol,,,,tuberculosis,,,,, +14384550,75,,affects,,Ergocalciferol,,,,psoriasis,,,,, +14233188,76,,affects,,Ergocalciferol,,,,Insulin resistance,,,,, +13916047,77,,affects,,Ergocalciferol,,,,hip fracture,,,,, +13794313,78,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, +13764162,79,,affects,,Ergocalciferol,,,,type 2 diabetes mellitus,,,,, +13437693,80,,affects,,Ergocalciferol,,,,Crohn disease,,,,, +13211992,81,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +13015298,82,,affects,,Ergocalciferol,,,,asthma,,,,, +12698804,83,,affects,,Ergocalciferol,,,,chronic renal failure syndrome,,,,, +12502345,84,,affects,,Ergocalciferol,,,,inflammatory bowel disease,,,,, +12032067,85,,affects,,Ergocalciferol,,,,multiple sclerosis,,,,, +11831475,86,,affects,,Ergocalciferol,,,,bone fracture,,,,, +10991167,87,,affects,,Ergocalciferol,,,,type 1 diabetes mellitus,,,,, +10917919,88,,affects,,Ergocalciferol,,,,primary hyperparathyroidism,,,,, +10608353,89,,affects,,Ergocalciferol,,,,Pregnancy,,,,, +8987937,90,,affects,,Ergocalciferol,,,,hip fracture,,,,, +8925552,91,,affects,,Ergocalciferol,,,,prostate cancer,,,,, +8894668,92,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +8321224,93,,affects,,Ergocalciferol,,,,neoplasm,,,,, +7878820,94,,affects,,Ergocalciferol,,,,Marchiafava-Bignami disease,,,,, +21952380,95,,produces,,Ergocalciferol,,,,obesity disorder,,,,, +21636964,96,,produces,,Ergocalciferol,,,,asthma,,,,, +20636497,97,,produces,,Ergocalciferol,,,,Pregnancy,,,,, +20444810,98,,produces,,Ergocalciferol,,,,Alzheimer disease,,,,, +15318015,99,,produces,,Ergocalciferol,,,,melanoma,,,,, +14384547,100,,produces,,Ergocalciferol,,,,psoriasis,,,,, diff --git a/util/chembl/convert_false.py b/util/chembl/convert_false.py index e3c0be4..a25e3be 100644 --- a/util/chembl/convert_false.py +++ b/util/chembl/convert_false.py @@ -79,8 +79,8 @@ def create_csvs(json_path: str, name: str): "Column": None, "Column": None }) - if sentence_id==400: - n=-400 + if sentence_id==4900: + n=-4900 labeled_records_df=pd.DataFrame(labeled_records, columns=labeled_columns) sentence_df = pd.DataFrame(sentence_records, columns=sentence_columns) triple_df = pd.DataFrame(triple_records, columns=triple_columns)